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living donor renal transplantation

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https://www.readbyqxmd.com/read/29773235/factors-associated-with-renal-function-compensation-after-donor-nephrectomy
#1
Carla Burballa, Marta Crespo, Dolores Redondo-Pachón, María José Pérez-Sáez, Carlos Arias-Cabrales, Marisa Mir, Albert Francés, Lluís Fumadó, Lluís Cecchini, Julio Pascual
INTRODUCTION: Kidney transplant donors lose 50% of their renal mass after nephrectomy. The remaining kidney compensates for this loss and it is estimated that 70% of the baseline renal function prior to donation is recovered. Factors associated with post-donation renal compensation are not well understood. METHODS: Retrospective study of 66 consecutive kidney donors (mean age 48.8 years, 74.2% women). We analysed the potential factors associated with the compensatory mechanisms of the remaining kidney by comparing donors according to their renal compensation rate (RCR) (Group A, infra-compensation [<70%]; Group B, normal compensation [>70%])...
May 14, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/29772565/safety-of-iohexol-administration-to-measure-glomerular-filtration-rate-in-different-patient-populations-a-25-year-experience
#2
Flavio Gaspari, Surabhi Thakar, Fabiola Carrara, Annalisa Perna, Matias Trillini, Maria Carolina Aparicio, Olimpia Diadei, Silvia Ferrari, Antonio Cannata, Nadia Stucchi, Piero Ruggenenti, Giuseppe Remuzzi, Norberto Perico
BACKGROUND/AIM: In clinical research setting, accurate and precise measurement of glomerular filtration rate (GFR) is essential to overcome the limitations of GFR estimation with equations, which are often unreliable. In recent decades, a method for measuring GFR by plasma clearance of iohexol, a non-ionic radiocontrast agent, was developed. To evaluate the safety of the procedure, we aimed to review all immediate adverse reactions that could be related to iohexol administration in our group's 25 years worth of experience...
May 17, 2018: Nephron
https://www.readbyqxmd.com/read/29769080/a-complex-culturally-targeted-intervention-to-reduce-hispanic-disparities-in-living-kidney-donor-transplantation-an-effectiveness-implementation-hybrid-study-protocol
#3
Elisa J Gordon, Jungwha Lee, Raymond H Kang, Juan Carlos Caicedo, Jane L Holl, Daniela P Ladner, Michelle D Shumate
BACKGROUND: The shortage of organs for kidney transplantation for patients with end-stage renal disease (ESRD) is magnified in Hispanics/Latin Americans in the United States. Living donor kidney transplantation (LDKT) is the treatment of choice for ESRD. However, compared to their representation on the transplant waitlist, fewer Hispanics receive a LDKT than non-Hispanic whites. Barriers to LDKT for Hispanics include: lack of knowledge, cultural concerns, and language barriers. Few interventions have been designed to reduce LDKT disparities...
May 16, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29753848/outcomes-of-conservative-management-of-asymptomatic-live-donor-kidney-stones
#4
Mehmet Sarier, Ibrahim Duman, Mehmet Callioglu, Ahmet Soylu, Sabri Tekin, Emrah Celep, Hasan Turan, Asuman Havva Yavuz, Alper Demirbas, Erdal Kukul
OBJECTIVES: To evaluate the long-term outcomes of asymptomatic stones ≤4 mm which are left in situ during renal transplantation (RT). METHODS: Between 2009 and 2017, 31 patients who received stone-bearing (≤4 mm) kidneys were analyzed. At their last follow-up, the patients were evaluated with CT imaging and the results were compared to the initial CT findings obtained during donor evaluation. RESULTS: The mean stone size was 2.9mm (range 1-4...
May 10, 2018: Urology
https://www.readbyqxmd.com/read/29753464/development-of-the-national-transplant-program-has-significantly-decreased-but-not-ended-transplant-tourism-in-montenegro
#5
M Ratkovic, N Basic Jukic, Z Kastelan, D Radunovic, P Kavaric, J Brezak, M Topalovic Grkovic, T Hudolin, V Prelevic
Organ transplantation has prolonged and improved the lives of many patients around the world. However, a widespread shortage of donors remains the main factor that has led to organ trafficking and transplant tourism. To stop transplant tourism and to provide optimal treatment for its citizens with end-stage renal disease, Montenegro started performing renal transplantations in September 2012. Thirty-five transplantations have been performed since that time, 34 from living donors and only 1 from a deceased donor...
March 12, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29743501/a-phase-i-clinical-trial-with-ex-vivo-expanded-recipient-regulatory-t-cells-in-living-donor-kidney-transplants
#6
James M Mathew, Jessica H-Voss, Ann LeFever, Iwona Konieczna, Cheryl Stratton, Jie He, Xuemei Huang, Lorenzo Gallon, Anton Skaro, Mohammed Javeed Ansari, Joseph R Leventhal
There is considerable interest in therapeutic transfer of regulatory T cells (Tregs) for controlling aberrant immune responses. Initial clinical trials have shown the safety of Tregs in hematopoietic stem cell transplant recipients and subjects with juvenile diabetes. Our hypothesis is that infusion(s) of Tregs may induce transplant tolerance thus avoiding long-term use of toxic immunosuppressive agents that cause increased morbidity/mortality. Towards testing our hypothesis, we conducted a phase I dose escalation safety trial infusing billions of ex vivo expanded recipient polyclonal Tregs into living donor kidney transplant recipients...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740879/return-on-investment-for-financial-assistance-for-living-kidney-donors-in-the-u-s
#7
Amit K Mathur, Jiawei Xing, David M Dickinson, Patricia H Warren, Kimberly A Gifford, Barry A Hong, Akinlolu Ojo, Robert M Merion
BACKGROUND: The National Living Donor Assistance Center (NLDAC) enables living donor kidney transplants through financial assistance of living donors, but its return on investment (ROI) through savings on dialysis costs remains unknown. METHODS: We retrospectively reviewed 2012-2015 data from NLDAC, the United States Renal Data System, and the Scientific Registry of Transplant Recipients to construct 1-year, 3-year, and 5-year ROI models based on NLDAC applications and national dialysis and transplant cost data...
May 8, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29731924/the-spectrum-of-histopathological-changes-in-the-renal-allograft-a-12-months-protocol-biopsy-study
#8
Galina Severova-Andreevska, Ladislava Grcevska, Gordana Petrushevska, Koco Cakalaroski, Aleksandar Sikole, Olivera Stojceva-Taneva, Ilina Danilovska, Ninoslav Ivanovski
INTRODUCTION: Renal transplantation became a routine and successful medical treatment for Chronic Kidney Disease in the last 30 years all over the world. Introduction of Luminex based Single Antigen Beads (SAB) and recent BANFF consensus of histopathological phenotypes of different forms of rejection enables more precise diagnosis and changes the therapeutic approach. The graft biopsies, protocol or cause, indicated, remain a golden diagnostic tool for clinical follow up of kidney transplant recipients (KTR)...
April 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29731096/causes-of-ineligibility-for-recipients-in-living-kidney-transplantation
#9
N Masaki, K Iwadoh, A Kondo, I Koyama, I Nakajima, S Fuchinoue
BACKGROUND: Even if a living donor candidate exists, there are some cases that do not result in kidney transplantation (KTx) due to problems on the recipient side. The aim of this study was to clarify causes of ineligibility for KTx in these cases, so as to make RTx more applicable for patients. METHODS: We targeted 470 patients with end-stage renal disease who applied for the primary kidney KTx from 2010 to 2012. Then we selected those who were not applicable for KTx and investigated recipient causes of ineligibility for KTx or not receiving KTx...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29731092/new-left-lobe-transplantation-procedure-with-caval-reconstruction-using-an-inverted-composite-graft-for-chronic-budd-chiari-syndrome-in-living-donor-liver-transplantation-a-case-report
#10
T Yagi, K Takagi, R Yoshida, Y Umeda, D Nobuoka, T Kuise, T Fujiwara, A Takaki
When the Budd-Chiari syndrome (BCS) lesion extends to the inferior vena cava (IVC) or the orifices of the hepatic vein, the thickened IVC and/or hepatic vein wall must be removed and IVC reconstruction is required in living-donor liver transplantation (LDLT). In various reports about IVC resection in LDLT for BCS, there are none about left lobe liver transplantation with reconstruction of the retrohepatic IVC (rhIVC). To overcome removal and reconstruction of the rhIVC in LDLT for BCS, we introduced a composite IVC graft that is applicable to both right and left lobe partial liver grafts for LDLT for BCS...
May 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29729082/a-case-series-of-perioperative-variables-in-relation-to-short-term-outcomes-in-pediatric-renal-transplant-recipients
#11
Celine Y Y Goh, Helen Hume-Smith, Nicos Kessaris, Stephen D Marks
Multiple perioperative variables have been shown in existing literature to influence long-term outcomes of pediatric RTx, such as allograft survival. Their impact on short-term outcomes is not as well-documented. This case series aims to investigate the effects of nine perioperative variables on two short-term outcomes in pRTR: 1-week post-operative eGFR and post-operative LOS. A total of 73 pRTR transplanted over 3 years from 2012 to 2014 at a single center were studied retrospectively and statistical analyses were performed...
May 5, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29725634/bowman-capsule-volume-and-related-factors-in-adults-with-normal-renal-function
#12
Takaya Sasaki, Nobuo Tsuboi, Kotaro Haruhara, Yusuke Okabayashi, Go Kanzaki, Kentaro Koike, Akimitsu Kobayashi, Izumi Yamamoto, Makoto Ogura, Takashi Yokoo
Introduction: Alterations in glomerular filtration can considerably influence the dynamics and functions of the Bowman capsule. Despite the potentially important role in maintaining normal renal functions, few studies have focused on Bowman capsule volume in normal human kidneys. Methods: We analyzed specimens from biopsies performed 1 hour after kidney transplantation from living donors without apparent renal disease. The measurements of all cross-sectional areas of the Bowman capsules and glomerular capillaries were used to estimate the mean Bowman capsule volume (BV) and glomerular capillary volume (GV) in each subject...
March 2018: KI Reports
https://www.readbyqxmd.com/read/29724177/effectiveness-of-informational-decision-aids-and-a-live-donor-financial-assistance-program-on-pursuit-of-live-kidney-transplants-in-african-american-hemodialysis-patients
#13
L Ebony Boulware, Patti L Ephraim, Jessica Ameling, LaPricia Lewis-Boyer, Hamid Rabb, Raquel C Greer, Deidra C Crews, Bernard G Jaar, Priscilla Auguste, Tanjala S Purnell, Julio A Lamprea-Monteleagre, Tope Olufade, Luis Gimenez, Courtney Cook, Tiffany Campbell, Ashley Woodall, Hema Ramamurthi, Cleomontina A Davenport, Kingshuk Roy Choudhury, Matthew R Weir, Donna S Hanes, Nae-Yuh Wang, Helene Vilme, Neil R Powe
BACKGROUND: African Americans have persistently poor access to living donor kidney transplants (LDKT). We conducted a small randomized trial to provide preliminary evidence of the effect of informational decision support and donor financial assistance interventions on African American hemodialysis patients' pursuit of LDKT. METHODS: Study participants were randomly assigned to receive (1) Usual Care; (2) the Providing Resources to Enhance African American Patients' Readiness to Make Decisions about Kidney Disease (PREPARED); or (3) PREPARED plus a living kidney donor financial assistance program...
May 3, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29723174/-it-s-hard-to-ask-examining-the-factors-influencing-decision-making-among-end-stage-renal-disease-patients-considering-approaching-family-and-friends-for-a-kidney
#14
Merryn A Jones, Jon Cornwall
AIM: People needing kidney transplants in New Zealand can receive organs from deceased donors or from a living kidney donor. This project explored issues surrounding donor recruitment, examining the lived experience of end-stage renal disease (ESRD) patients in order to facilitate improved donor recruitment for ESRD patients. METHOD: A qualitative study comprising interviews of ESRD patients in Hawke's Bay, focusing on the factors surrounding approaching family and friends for a kidney...
May 4, 2018: New Zealand Medical Journal
https://www.readbyqxmd.com/read/29699451/an-explore-transplant-group-randomized-controlled-education-trial-to-increase-dialysis-patients-decision-making-and-pursuit-of-transplantation
#15
Amy D Waterman, John Devin Peipert
INTRODUCTION: Dialysis centers must provide transplant education to patients but often do not address the risks and benefits of living and deceased donor transplant. RESEARCH QUESTIONS: In a group randomized controlled trial of 20 dialysis centers and 253 patients, we assessed whether the Explore Transplant education program increased patients' readiness to pursue transplant, transplant knowledge, informed transplant decision-making, discussions about transplant with potential living donors, pursuit and receipt of living or deceased donor transplant, and whether these effects varied by race...
January 1, 2018: Progress in Transplantation
https://www.readbyqxmd.com/read/29697354/comparison-between-bipolar-lymphatic-vessels-cautery-and-suture-ligature-in-prevention-of-postrenal-transplant-lymphocele-formation-a-randomized-controlled-trial
#16
Nasser Simforoosh, Ali Tabibi, Hamed Mohseni Rad, Hamid Reza Gholamrezaie
OBJECTIVES: In this randomized controlled trial, our aim was to compare bipolar cautery of lymphatic vessels with standard silk-tie ligation in renal transplant procedures for prevention of lymphocele formation. MATERIALS AND METHODS: Sixty end-stage renal disease patients were enrolled in a prospective randomized controlled trial. The mean age of recipients in the suture ligature group was 41.6 years (range, 6-65 years) and 40.9 years in the bipolar cautery group...
April 26, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29694726/treatment-and-management-options-for-the-hepatitis-c-virus-infected-kidney-transplant-candidate
#17
REVIEW
Adriana Dejman, Marco A Ladino, David Roth
A substantial body of literature has unequivocally established that prevalent hepatitis C virus infection in chronic kidney disease (CKD), end stage renal disease (ESRD) and kidney transplant recipients is associated with a negative impact on patient survival. As a consequence of remarkable work that explained the details of the hepatitis C virus (HCV) genome, a class of drugs referred to as the direct-acting antiviral (DAA) agents were developed that targeted specific key sites in viral replication. Large clinical trials in the HCV-infected general population followed soon after that demonstrated cure rates exceeding 95%...
April 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29694723/timing-of-hepatitis-c-virus-infection-treatment-in-kidney-transplant-candidates
#18
REVIEW
Abraham Cohen-Bucay, Jean M Francis, Craig E Gordon
Hepatitis C virus (HCV) infection is prevalent in patients with kidney disease including transplant candidates and recipients. It is associated with increased morbidity and mortality in end-stage renal disease patients and also increases the risk of allograft rejection and decreases allograft and patient survival post-transplant. Newly developed direct acting antivirals have revolutionized the way HCV is treated. Whether patients are treated before or after kidney transplantation, the cure rates with direct acting antivirals are >90%...
April 2018: Hemodialysis International
https://www.readbyqxmd.com/read/29692689/evaluation-of-deceased-kidney-donors-for-renal-stone-disease-is-computed-tomography-needed
#19
REVIEW
Senol Tonyali, Ahmet M Aydin
Objective: To investigate the clinical consequences of neglected risk of urolithiasis in deceased kidney donors in routine clinical practice, this study focused on different management options for transplanted allograft stones, and tried to find new solutions for more accurate detection of urolithiasis in deceased kidney donors prior to renal transplantation. Methods and Results: The overall prevalence of stone disease in endemic countries is between 7 and 29%. Because of the increased risk for stone disease in epidemic countries, screening renal grafts from deceased donors necessitates more sensitive imaging tests...
March 2018: Current Urology
https://www.readbyqxmd.com/read/29688993/british-transplantation-society-renal-association-uk-guidelines-for-living-donor-kidney-transplantation-2018-summary-of-updated-guidance
#20
Peter A Andrews, Lisa Burnapp
No abstract text is available yet for this article.
April 23, 2018: Transplantation
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