keyword
https://read.qxmd.com/read/34911856/risk-factors-for-urinary-tract-infection-in-kidney-transplantation-from-brain-death-donor-and-its-role-in-graft-function
#21
JOURNAL ARTICLE
Qianqian Ye, Lielin Wu, Bisong Zhu, Gang Zhang, Bo Yang, Peng Jin, Xiangrong Zhu, Jinliang Xie, Xiang Ding
OBJECTIVES: Urinary tract infection (UTI) is the most common infection complication after kidney transplantation, and the reports of the incidence vary greatly among different centers. This study aims to explore the risk factors for UTI after kidney transplantation with the donation from brain death (DBD) and the impact on graft function, thus to provide theoretical basis for comprehensive prevention and treatment of UTI after kidney transplantation. METHODS: The clinical and laboratory data of DBD kidney transplantation from January 2017 to December 2018 in Xiangya Hospital, Central South University were collected and retrospectively analyzed...
November 28, 2021: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://read.qxmd.com/read/34418160/postoperative-acute-kidney-injury-and-renal-replacement-therapy-after-dcd-lung-transplantation
#22
JOURNAL ARTICLE
Alessandra Verzelloni Sef, Davorin Sef, Vladimir Trkulja, Binu Raj, Nicholas James Lees, Christopher Walker, Ian McGovern, Jerry Mitchell, Fabio De Robertis, Ulrich Stock
Acute kidney injury (AKI) after lung transplantation (LTx) is a common complication. We aimed to assess whether donation after circulatory death (DCD) is associated with an increased risk of AKI and renal replacement therapy (RRT) in the early postoperative period compared to the donation after brain death (DBD). Retrospective data on a cohort (N = 95) of LTx patients (DCD n = 17, DBD n = 78) characterized by no use of ex-vivo lung perfusion were analyzed for the incidence of AKI within 30 postoperative days and incidence of RRT within 7 and 30 days...
February 2022: Clinical Transplantation
https://read.qxmd.com/read/34288129/transplantation-of-kidneys-after-normothermic-perfusion-a-single-center-experience
#23
JOURNAL ARTICLE
Robert Pearson, Colin Geddes, Patrick Mark, Marc Clancy, John Asher
BACKGROUND: In order to expand the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional perfusion (NRP) to assess and improve liver viability.1,2 NRP may also improve outcomes in kidney transplantation.We present our single center experience of outcomes in imported kidneys following NRP. METHODS: Data was obtained from a prospectively maintained database between December 2012 and September 2018. Primary endpoints were incidence of delayed graft function (DGF) and estimated glomerular filtration rate (eGFR)...
October 2021: Clinical Transplantation
https://read.qxmd.com/read/33841864/kidney-transplantation-outcomes-from-elderly-donors-after-circulatory-death-a-comparison-with-elderly-brain-dead-donors
#24
JOURNAL ARTICLE
Anna Buxeda, Gonzalo Velis, Carlos Arias-Cabrales, Ana Zapatero, Carla Burballa, Dolores Redondo-Pachón, Marisa Mir, Marta Crespo, Julio Pascual, María José Pérez-Sáez
Background: The use of kidneys from elderly controlled donation after circulatory death (cDCD) donors has increased significantly in recent years. Concerns about outcomes achieved with these elderly cDCD kidneys have arisen. We aimed to compare outcomes from elderly cDCD kidney transplant recipients (KTrs) and elderly donation after brain death donors (DBDs) in KTrs. Methods: We conducted a single-centre retrospective study including 87 cDCD-KTrs (46 from donors ≥65 years of age and 41 from <65 years) and 126 DBD-KTrs from donors ≥65 years of age from 2013 through 2017)...
April 2021: Clinical Kidney Journal
https://read.qxmd.com/read/32989785/utilization-of-extracorporeal-membrane-oxygenation-in-dcd-and-dbd-lung-transplants-a-2-year-single-center-experience
#25
JOURNAL ARTICLE
Davorin Sef, Alessandra Verzelloni Sef, Prashant Mohite, Ulrich Stock, Vladimir Trkulja, Binu Raj, Diana Garcia Saez, Balakrishnan Mahesh, Fabio De Robertis, Andre Simon
Donation after circulatory death (DCD) has the potential to expand the lung donor pool. We aimed to assess whether DCD affected the need for perioperative extracorporeal membrane oxygenation (ECMO) and perioperative outcomes in lung transplantation (LTx) as compared to donation after brain death (DBD). All consecutive LTxs performed between April 2017 and March 2019 at our tertiary center were analyzed. Donor and recipient preoperative characteristics, utilization of ECMO, and perioperative clinical outcomes were compared between DCD and DBD LTx...
December 2020: Transplant International
https://read.qxmd.com/read/32865209/hypoperfusion-warm-ischaemia-time-in-renal-transplants-from-donors-after-circulatory-death
#26
JOURNAL ARTICLE
Ioannis D Kostakis, Theodoros Kassimatis, Clare Flach, Nikolaos Karydis, Nicos Kessaris, Ioannis Loukopoulos
BACKGROUND: The donor hypoperfusion phase before asystole in renal transplants from donors after circulatory death (DCD) has been considered responsible for worse outcomes than those from donors after brain death (DBD). METHODS: We included 10 309 adult renal transplants (7128 DBD and 3181 DCD; 1 January 2010-31 December 2016) from the UK Transplant Registry. We divided DCD renal transplants into groups according to hypoperfusion warm ischaemia time (HWIT). We compared delayed graft function (DGF) rates, primary non-function (PNF) rates and graft survival among them using DBD renal transplants as a reference...
August 31, 2020: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/32726350/improving-outcomes-for-donation-after-circulatory-death-kidney-transplantation-science-of-the-times
#27
JOURNAL ARTICLE
Michèle J C de Kok, Alexander F M Schaapherder, Ian P J Alwayn, Frederike J Bemelman, Jacqueline van de Wetering, Arjan D van Zuilen, Maarten H L Christiaans, Marije C Baas, Azam S Nurmohamed, Stefan P Berger, Esther Bastiaannet, Rutger J Ploeg, Aiko P J de Vries, Jan H N Lindeman
The use of kidneys donated after circulatory death (DCD) remains controversial due to concerns with regard to high incidences of early graft loss, delayed graft function (DGF), and impaired graft survival. As these concerns are mainly based on data from historical cohorts, they are prone to time-related effects and may therefore not apply to the current timeframe. To assess the impact of time on outcomes, we performed a time-dependent comparative analysis of outcomes of DCD and donation after brain death (DBD) kidney transplantations...
2020: PloS One
https://read.qxmd.com/read/32576429/recipient-and-allograft-survival-following-donation-after-circulatory-death-versus-donation-after-brain-death-for-renal-transplantation-a-systematic-review-and-meta-analysis
#28
REVIEW
Paschalis Gavriilidis, Nicholas G Inston
BACKGROUND-OBJECTIVES: Current evidence based on retrospective and prospective studies demonstrates that donation after circulatory death (DCD) grafts are more susceptible to delayed graft function (DGF) than donation after brain death (DBD) grafts. The short- and long-term survival outcomes of the two cohorts are unclear. Therefore, we performed a systematic review and meta-analysis to estimate the patient and allograft survival outcomes for DCD and DBD in renal transplant surgery. METHODS: Systematic literature searches were conducted by searching various databases...
October 2020: Transplantation Reviews
https://read.qxmd.com/read/32573027/strict-selection-criteria-in-uncontrolled-donation-after-circulatory-death-provides-excellent-long-term-kidney-graft-survival
#29
JOURNAL ARTICLE
Eduardo Miñambres, Emilio Rodrigo, Borja Suberviola, Rosalía Valero, Alfredo Quintana, Félix Campos, Juan Carlos Ruiz-San Millán, María Ángeles Ballesteros
BACKGROUND: We aimed to report our experience in uncontrolled donation after circulatory death (uDCD) kidney transplantation applying a strict donor selection and preservation criteria. METHODS: All kidney recipients who received a graft from a local uDCD. As controls we included all renal transplants from local standard criteria brain death donors (DBD). Normothermic regional perfusion was the preservation method in all cases. RESULTS: A total of 19 kidneys from uDCD donors were included and 67 controls...
June 23, 2020: Clinical Transplantation
https://read.qxmd.com/read/32433240/dcd-renal-transplantation-from-donors-with-acute-kidney-injury
#30
COMPARATIVE STUDY
Daniel Lia, Pamela Singer, Vinay Nair, Jingyan Yang, Lewis Teperman, Elliot Grodstein
BACKGROUND: Deceased donor kidneys with acute kidney injury (AKI) and donation after circulatory death (DCD) kidneys are viable sources of organs. The outcomes of renal transplantation from DCD donors with AKI are not known. METHODS: A retrospective review of deceased donor renal transplants performed from 2006 to 2016 was conducted using the United Network for Organ Sharing dataset. Donors were stratified by DCD or brain dead status and by AKI stage. Recipients were followed until graft failure or the end of study...
April 1, 2021: Transplantation
https://read.qxmd.com/read/32252998/comparison-between-kidney-transplantation-after-circulatory-death-and-after-brain-death-a-monocentric-retrospective-study-after-1-year-of-follow-up
#31
COMPARATIVE STUDY
Giacomo Mori, Andrea Solazzo, Laura Tonelli, Francesca Facchini, Francesco Fontana, Gaetano Alfano, Stefano Baroni, Gianni Cappelli
BACKGROUND: Donation after circulatory death (DCD) is a solid resource to widen the kidney donor pool. Italian activity has grown in the last years with encouraging results. Our center has been active in DCD kidney transplantation (KTX) since November 2017, providing 22.5% of Italian DCD donations in 2018. We present a single-center retrospective analysis after a 1-year follow-up comparing DCD and donation after brain death (DBD) KTX outcomes. METHODS: DCD (controlled only) and DBD KTX performed in our center from November 2017 to December 2018 were considered...
June 2020: Transplantation Proceedings
https://read.qxmd.com/read/32189415/renal-dysfunction-after-liver-transplantation-effect-of-donor-type
#32
JOURNAL ARTICLE
Dagmar Kollmann, Shuet Fong Neong, Roizar Rosales, Bettina E Hansen, Gonzalo Sapisochin, Stuart McCluskey, Mamatha Bhat, Mark S Cattral, Les Lilly, Ian D McGilvray, Anand Ghanekar, David R Grant, Markus Selzner, Florence S H Wong, Nazia Selzner
Recipients of donation after circulatory death (DCD) grafts are reportedly at higher risk of developing renal dysfunction after liver transplantation (LT). We compared the development of acute kidney injury (AKI) and chronic kidney disease (CKD) after LT in recipients of DCD versus donation after brain death (DBD) or living donor liver transplantation (LDLT) livers. Adult recipients of DBD, LDLT, and DCD between 2012 and 2016 at Toronto General Hospital were included. AKI was defined as a post-LT increase of serum creatinine (sCr) ≥26...
June 2020: Liver Transplantation
https://read.qxmd.com/read/32096878/the-management-of-lower-limb-arteriovenous-grafts-in-the-peri-operative-period-following-renal-transplantation
#33
JOURNAL ARTICLE
Andrej Isaak, Marta J Madurska, Karen S Stevenson, Lorenz Gürke, David B Kingsmore
BACKGROUND: The presence of a lower limb arteriovenous graft (LL-AVG) is indicative of a group of complex haemodialysis patients who have precarious long-term vascular access. The aim of this study is to describe our experience of the clinical decisions and interactions between LL-AVG and renal transplantation. METHODS: The records of 23 patients who received a transplant in the presence of a LL-AVG between 2010 and 2018 were analysed: firstly, to determine if patients with a LL-AVG received extended criteria transplants, the implantation procedure, and the management of the LL-AVG in the post-operative period...
February 25, 2020: Clinical Transplantation
https://read.qxmd.com/read/32031711/hypothermic-machine-perfusion-is-superior-to-static-cold-storage-in-deceased-donor-kidney-transplantation-a-meta-analysis
#34
REVIEW
Samuel J Tingle, Rodrigo S Figueiredo, John Ag Moir, Michael Goodfellow, Emily R Thompson, Ibrahim K Ibrahim, Lucy Bates, David Talbot, Colin H Wilson
BACKGROUND: There remains a lack of consensus on the optimal storage method for deceased donor kidneys. This meta-analysis compares storage with hypothermic machine perfusion (HMP) versus traditional static cold storage (SCS). METHODS: The Cochrane Kidney and Transplant Specialised Register was searched to identify (quasi-)RCTs to include in our meta-analysis. PRISMA guidelines were used to perform and write this review. RESULTS: There is high-certainty evidence that HMP reduces the risk of delayed graft function (DGF) when compared to SCS (2138 participants from 14 studies, RR=0...
February 7, 2020: Clinical Transplantation
https://read.qxmd.com/read/31865161/variable-benefits-of-antibody-induction-by-kidney-allograft-type
#35
JOURNAL ARTICLE
Aaron M Williams, Meredith Barrett, Abigail R Smith, Ranganath G Kathawate, Kenneth J Woodside, Randall S Sung
BACKGROUND: Kidneys from acute renal failure (ARF), expanded criteria donors (ECD), and donation after cardiac death (DCD) donors are often discarded due to concerns for delayed graft function (DGF) and graft failure. Induction immunosuppression may be used to minimize these risks, but practices vary widely. Furthermore, little is known regarding national outcomes of transplant recipients receiving induction immunosuppression for receipt of high-risk kidneys. MATERIALS AND METHODS: Using a center-level retrospective study, deceased donor transplants (115,485) from the Scientific Registry of Transplant Recipients from January 2003 to June 2016 were evaluated...
April 2020: Journal of Surgical Research
https://read.qxmd.com/read/31373472/-kidney-transplant-from-donors-after-cardiac-death-dcd-monocentric-experience-and-literature-review
#36
JOURNAL ARTICLE
Marco Busutti, Vera Minerva, Andrea Angeletti, Valeria Corradetti, Chiara Zanfi, Matteo Ravaioli, Giorgia Comai, Gaetano La Manna
Kidney transplant from donor after circulatory death (DCD) represents a valid choice to increase the incidence of renal transplantation, presenting recipients' and grafts' survival rates comparable to those from brain dead donors (DBD). In January 2016, the Transplant Referral Center in the Emilia Romagna region has started a DCD program. In the present study we report on the first 30 months of the program as far as our own Center in Bologna is concerned, and we provide a comparison with DBD transplants performed over the same period...
July 24, 2019: Giornale Italiano di Nefrologia: Organo Ufficiale Della Società Italiana di Nefrologia
https://read.qxmd.com/read/31357488/rapid-or-slow-time-to-brain-death-impact-on-kidney-graft-injuries-in-an-allotransplantation-porcine-model
#37
JOURNAL ARTICLE
Thomas Kerforne, Sébastien Giraud, Jérôme Danion, Raphael Thuillier, Pierre Couturier, William Hebrard, Olivier Mimoz, Thierry Hauet
The use of donors deceased after brain death (DBD) with extended criteria in response to the shortage of grafts leads to the removal of more fragile kidneys. These grafts are at greater risk of not being grafted or delayed function. A better knowledge of the pathophysiology of DBDs would improve this situation. There is a difference between the results from animal models of DBD and the clinical data potentially explained by the kinetics of brain death induction. We compared the effect of the induction rate of brain death on the recovery of post-transplant renal function in a pig model of DBD followed by allografts in nephrectomized pigs...
July 26, 2019: International Journal of Molecular Sciences
https://read.qxmd.com/read/31301968/controlled-donation-after-circulatory-death-dcd-donors-a-focus-on-the-utilization-of-pediatric-donors-and-outcomes-after-lung-transplantation
#38
JOURNAL ARTICLE
Gregory Snell, Bronwyn Levvey, Miranda Paraskeva, Helen Whitford, Kovi Levin, Trevor Williams, David McGiffin, Glen Westall
BACKGROUND: Access to timely suitably size-matched quality organs remains a challenge for pediatric (pLTx) and adult (aLTx) lung transplantation. The outcomes of donation after circulatory death (DCD) donor lungs from pediatric or adult donors are rarely reported. METHODS: This report describes the controlled DCD and pLTx activity (≤ age 18 years) and outcomes since 2006 when DCD LTx started at our center at the Alfred Hospital. RESULTS: Forty pLTx have been performed since 2006, 9 utilizing DCD and 31 donation after brain death (DBD) donors...
June 19, 2019: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/31193600/equivalent-long-term-transplantation-outcomes-for-kidneys-donated-after-brain-death-and-cardiac-death-conclusions-from-a-nationwide-evaluation
#39
JOURNAL ARTICLE
Alexander Schaapherder, Leonie G M Wijermars, Dorottya K de Vries, Aiko P J de Vries, Frederike J Bemelman, Jacqueline van de Wetering, Arjan D van Zuilen, Maarten H L Christiaans, Luuk H Hilbrands, Marije C Baas, Azam S Nurmohamed, Stefan P Berger, Ian P Alwayn, Esther Bastiaannet, Jan H N Lindeman
Background: Despite growing waiting lists for renal transplants, hesitations persist with regard to the use of deceased after cardiac death (DCD) renal grafts. We evaluated the outcomes of DCD donations in The Netherlands, the country with the highest proportion of DCD procedures (42.9%) to test whether these hesitations are justified. Methods: This study included all procedures with grafts donated after brain death (DBD) (n = 3611) and cardiac death (n = 2711) performed between 2000 and 2017...
October 2018: EClinicalMedicine
https://read.qxmd.com/read/30947384/chronic-kidney-disease-after-liver-transplantation-impact-of-extended-criteria-grafts
#40
JOURNAL ARTICLE
Marit Kalisvaart, Andrea Schlegel, Palak J Trivedi, Keith Roberts, Darius F Mirza, Thamara Perera, John I Isaac, James Ferguson, Jeroen de Jonge, Paolo Muiesan
The use of extended criteria donor (ECD) grafts has been associated with acute kidney injury (AKI) after liver transplantation. However, the relation between graft quality and development of chronic kidney disease (CKD) remains unknown. Therefore, the aim of this study was to analyze the impact of ECD grafts for CKD after liver transplantation. All patients (2007-2015) transplanted for end-stage liver disease at our center were assessed. Longterm kidney function was divided into 4 groups: no CKD (estimated glomerular filtration rate [eGFR], ≥60 mL/minute/1...
June 2019: Liver Transplantation
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