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Raymond douglas

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https://www.readbyqxmd.com/read/28060831/using-automated-hba1c-testing-to-detect-diabetes-mellitus-in-orthopedic-inpatients-and-its-effect-on-outcomes
#1
Elif I Ekinci, Alvin Kong, Leonid Churilov, Natalie Nanayakkara, Wei Ling Chiu, Priya Sumithran, Frida Djukiadmodjo, Erosha Premaratne, Elizabeth Owen-Jones, Graeme Kevin Hart, Raymond Robbins, Andrew Hardidge, Douglas Johnson, Scott T Baker, Jeffrey D Zajac
AIMS: The prevalence of diabetes is rising, and people with diabetes have higher rates of musculoskeletal-related comorbidities. HbA1c testing is a superior option for diabetes diagnosis in the inpatient setting. This study aimed to (i) demonstrate the feasibility of routine HbA1c testing to detect the presence of diabetes mellitus, (ii) to determine the prevalence of diabetes in orthopedic inpatients and (iii) to assess the association between diabetes and hospital outcomes and post-operative complications in orthopedic inpatients...
2017: PloS One
https://www.readbyqxmd.com/read/28059121/structural-effects-of-lanthanide-dopants-on-alumina
#2
Ketan Patel, Victoria Blair, Justin Douglas, Qilin Dai, Yaohua Liu, Shenqiang Ren, Raymond Brennan
Lanthanide (Ln(3+)) doping in alumina has shown great promise for stabilizing and promoting desirable phase formation to achieve optimized physical and chemical properties. However, doping alumina with Ln elements is generally accompanied by formation of new phases (i.e. LnAlO3, Ln2O3), and therefore inclusion of Ln-doping mechanisms for phase stabilization of the alumina lattice is indispensable. In this study, Ln-doping (400 ppm) of the alumina lattice crucially delays the onset of phase transformation and enables phase population control, which is achieved without the formation of new phases...
January 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27998211/axial-and-appendicular-body-proportions-for-evaluation-of-limb-and-trunk-asymmetry
#3
Douglas S Weinberg, Raymond W Liu, Samuel Q Li, James O Sanders, Daniel R Cooperman
Background and purpose - When children with irregular body proportions or asymmetric limbs present, it may be unclear where the pathology is located. An improved understanding of the clinical ratio between upper extremity, lower extremity, and spine length may help elucidate whether there is disproportion between the trunk and limbs, and whether there is a reduction deficit of the shorter limb rather than hypertrophy of the longer limb. Patients and methods - We used the Brush Foundation study of child growth and development, which was a prospective, longitudinal study of healthy children between the 1930s and the 1950s, and we collected serial clinical measurements for 290 children at 3,326 visits...
December 21, 2016: Acta Orthopaedica
https://www.readbyqxmd.com/read/27997462/customized-minimally-invasive-orbital-decompression-surgery-improves-lower-eyelid-retraction-and-contour-in-thyroid-eye-disease
#4
Allan C Pieroni Goncalves, Shivani Gupta, Mario L R Monteiro, Raymond S Douglas
PURPOSE: To investigate the outcome of a customized approach with targeted zygomatic basin bone removal orbital decompression in lower eyelid retraction and contour of patients with thyroid eye disease. METHODS: In a comparative case series, clinical charts and photos of a consecutive sample of 92 patients with thyroid eye disease submitted to different types orbital decompression were studied. Exophthalmos, midpupil to lower eyelid margin distances (MRD2) at 11 meridians, and globe position were measured and compared according to the types of decompression...
December 16, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27990645/evaluation-of-a-unique-defibrillation-unit-with-dual-vector-biphasic-waveform-capabilities-towards-a-miniaturized-defibrillator
#5
Hideo Okamura, Christopher V Desimone, Ammar M Killu, Emily J Gilles, Jason Tri, Roshini Asirvatham, Dejae J Ladewig, Scott H Suddendorf, Joanne M Powers, Christina M Wood-Wentz, Peter D Gray, Douglas M Raymond, Shelley J Savage, Walter T Savage, Charles J Bruce, Samuel J Asirvatham, Paul A Friedman
BACKGROUND: Automated external defibrillators can provide life-saving therapies to treat ventricular fibrillation. We developed a prototype unit that can deliver a unique shock waveform produced by four independent capacitors that is delivered through two shock vectors, with the rationale of providing more robust shock pathways during emergent defibrillation. We describe the initial testing and feasibility of this unique defibrillation unit, features of which may enable downsizing of current defibrillator devices...
December 19, 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27942968/false-positive-cultures-after-native-knee-aspiration-true-or-false
#6
Jason M Jennings, Douglas A Dennis, Raymond H Kim, Todd M Miner, Charlie C Yang, David C McNabb
BACKGROUND: Synovial fluid aspiration is a routine practice used by most orthopaedic surgeons to aid in the diagnosis of joint infection. In patients for whom there is a low pretest probability of infection, a positive culture-particularly if it is a broth-only culture-may be considered a contaminant, especially if the bacterial species are skin pathogens. To our knowledge no study has evaluated the incidence of contamination of aspirations from the native knee. QUESTIONS/PURPOSES: What is the frequency of false-positive cultures among knee aspirations of the native knee? METHODS: Two hundred patients, with a total of 200 knees, with the diagnosis of degenerative osteoarthritis undergoing a total knee arthroplasty (TKA) were identified for this study...
December 9, 2016: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/27941471/the-brow-fat-pad-suspension-suture-safety-profile-and-clinical-observations
#7
Kian Eftekhari, Grace L Peng, Hannah Landsberger, Raymond Douglas, Guy G Massry
PURPOSE: To evaluate the safety, subjectively assess outcome, and emphasize surgical pearls and critical clinical observations of upper blepharoplasty performed in conjunction with the brow fat pad suspension suture procedure, previously referred to as a "browpexy variant" or "brassiere suture procedure." METHODS: A retrospective 4-year analysis of patients who underwent the brow fat pad suspension suture with upper blepharoplasty was performed. Adjunctive procedures (brow lift and ptosis repair) were categorized...
December 9, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27930752/prevalence-of-body-dysmorphic-disorder-and-surgeon-diagnostic-accuracy-in-facial-plastic-and-oculoplastic-surgery-clinics
#8
Andrew W Joseph, Lisa Ishii, Shannon S Joseph, Jane I Smith, Peiyi Su, Kristin Bater, Patrick Byrne, Kofi Boahene, Ira Papel, Theda Kontis, Raymond Douglas, Christine C Nelson, Masaru Ishii
Importance: Body dysmorphic disorder (BDD) is a relative contraindication for facial plastic surgery, but formal screening is not common in practice. The prevalence of BDD in patients seeking facial plastic surgery is not well documented. Objective: To establish the prevalence of BDD across facial plastic and oculoplastic surgery practice settings, and estimate the ability of surgeons to screen for BDD. Design, Setting, and Participants: This multicenter prospective study recruited a cohort of 597 patients who presented to academic and private facial plastic and oculoplastic surgery practices from March 2015 to February 2016...
December 8, 2016: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/27916578/patellar-component-design-influences-size-selection-and-coverage
#9
Charlie C Yang, Douglas A Dennis, Patrick G Davenport, Raymond H Kim, Todd M Miner, Derek R Johnson, Peter J Laz
BACKGROUND: Patellofemoral (PF) complications following total knee arthroplasty continue to occur. Outcomes are influenced by implant design, size and alignment in addition to patient factors. The objective of this study was to assess the effect of implant design, specifically round versus oval dome patellar components, on size selected and bony coverage in a population of 100 patients. METHODS: Intraoperative assessments of patella component size were performed using surgical guides for round and oval designs...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27846035/ibd-live-case-series-case-6-persistent-skin-lesions-in-a-patient-with-crohn-s-disease-you-hear-hoof-beats-and-discover-a-zebra
#10
Dhyan Rajan, Julia B Greer, Miguel D Regueiro, Leonard Baidoo, David G Binion, Hans H Herfarth, Corey A Siegel, Douglas J Hartman, Francis A Farraye, Ioannis E Koutroubakis, Myron H Brand, Emmanuelle D Williams, Alka Goyal, Raymond K Cross
No abstract text is available yet for this article.
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27821172/a-positive-feedback-loop-involving-the-wnt-%C3%AE-catenin-myc-sox2-axis-defines-a-highly-tumorigenic-cell-subpopulation-in-alk-positive-anaplastic-large-cell-lymphoma
#11
Chengsheng Wu, Hai-Feng Zhang, Nidhi Gupta, Abdulraheem Alshareef, Qian Wang, Yung-Hsing Huang, Jamie T Lewis, Donna N Douglas, Norman M Kneteman, Raymond Lai
BACKGROUND: We have previously described the existence of two phenotypically distinct cell subsets in ALK-positive anaplastic large cell lymphoma (ALK + ALCL) based on their differential responsiveness to a Sox2 reporter (SRR2), with reporter-responsive (RR) cells being more tumorigenic and chemoresistant than reporter-unresponsive (RU) cells. However, the regulator(s) of RU/RR dichotomy are not identified. In this study, we aim to delineate the key regulator(s) of RU/RR dichotomy...
November 8, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27813347/early-high-intensity-versus-low-intensity-rehabilitation-after-total-knee-arthroplasty-a-randomized-controlled-trial
#12
Michael Bade, Tamara Struessel, Michael Dayton, Jared Foran, Raymond Kim, Todd Miner, Pamela Wolfe, Wendy Kohrt, Douglas Dennis, Jennifer Stevens-Lapsley
OBJECTIVE: The purpose of this study was to examine the safety and efficacy of a high-intensity progressive rehabilitation protocol (HI) beginning 4 days after total knee arthroplasty (TKA) compared to a low-intensity (LI) rehabilitation protocol. METHODS: One hundred sixty-two participants (aged 63±7 years; 89 females) were randomized to either the HI group or LI group after TKA. Key components of the HI intervention were the utilization of progressive resistance exercises and a rapid progression to weight-bearing exercises and activities...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27780885/futuretox-iii-bridges-for-translation
#13
Daland R Juberg, Thomas B Knudsen, Miriam Sander, Nancy B Beck, Elaine M Faustman, Donna L Mendrick, John R Fowle, Thomas Hartung, Raymond R Tice, Emmanuel Lemazurier, Richard A Becker, Suzanne Compton Fitzpatrick, George P Daston, Alison Harrill, Ronald N Hines, Douglas A Keller, John C Lipscomb, David Watson, Tina Bahadori, Kevin M Crofton
Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making...
October 25, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27755273/ibd-live-case-series-case-6
#14
Dhyan Rajan, Julia B Greer, Miguel D Regueiro, Leonard Baidoo, David G Binion, Hans H Herfarth, Corey A Siegel, Douglas J Hartman, Francis A Farraye, Ioannis E Koutroubakis, Myron H Brand, Emmanuelle D Williams, Alka Goyal, Raymond K Cross
No abstract text is available yet for this article.
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27733493/canadian-registry-of-implantable-electronic-device-outcomes-surveillance-of-the-riata-lead-under-advisory
#15
Ratika Parkash, Bernard Thibault, Iqwal Mangat, Benoit Coutu, Matthew Bennett, Jeffrey Healey, Atul Verma, Francois Philippon, Roopinder Sandhu, Douglas Cameron, Felix Ayala-Paredes, Laurence Sterns, Vidal Essebag, Teresa Kus, Pablo Nery, Elizabeth Stephenson, Raymond Yee, Derek Exner, Satish Toal, David Birnie, George Wells, Andrew Krahn
BACKGROUND: The Riata lead under advisory has posed a unique clinical scenario where inside-out abrasion results in externalization of conductor cables, with a higher risk of electrical failure. We developed a comprehensive registry to assist with clinical management of this lead. METHODS AND RESULTS: This Canadian registry reports the findings of 3763 (74.2% of all Riata leads in Canada) Riata leads under advisory, with a mean follow-up time of 8.9±1.5 years. The overall electrical failure rate was 5...
October 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27727233/randomised-open-label-phase-ii-study-of-gemcitabine-with-and-without-imm-101-for-advanced-pancreatic-cancer
#16
Angus G Dalgleish, Justin Stebbing, Douglas J A Adamson, Seema Safia Arif, Paolo Bidoli, David Chang, Sue Cheeseman, Robert Diaz-Beveridge, Carlos Fernandez-Martos, Rob Glynne-Jones, Cristina Granetto, Bartomeu Massuti, Karen McAdam, Raymond McDermott, Andrés J Muñoz Martín, Demetris Papamichael, Roberto Pazo-Cid, Jose M Vieitez, Alberto Zaniboni, Kevin J Carroll, Shama Wagle, Andrew Gaya, Satvinder S Mudan
No abstract text is available yet for this article.
October 25, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27638987/joint-sogc-ccmg-opinion-for-reproductive-genetic-carrier-screening-an-update-for-all-canadian-providers-of-maternity-and-reproductive-healthcare-in-the-era-of-direct-to-consumer-testing
#17
R Douglas Wilson, Isabelle De Bie, Christine M Armour, Richard N Brown, Carla Campagnolo, June C Carroll, Nan Okun, Tanya Nelson, Rhonda Zwingerman, Francois Audibert, Jo-Ann Brock, Richard N Brown, Carla Campagnolo, June C Carroll, Isabelle De Bie, Jo-Ann Johnson, Nan Okun, Melanie Pastruck, Karine Vallée-Pouliot, R Douglas Wilson, Rhonda Zwingerman, Christine Armour, David Chitayat, Isabelle De Bie, Sara Fernandez, Raymond Kim, Josee Lavoie, Norma Leonard, Tanya Nelson, Sherry Taylor, Margot Van Allen, Clara Van Karnebeek
OBJECTIVE: This guideline was written to update Canadian maternity care and reproductive healthcare providers on pre- and postconceptional reproductive carrier screening for women or couples who may be at risk of being carriers for autosomal recessive (AR), autosomal dominant (AD), or X-linked (XL) conditions, with risk of transmission to the fetus. Four previous SOGC- Canadian College of Medical Geneticists (CCMG) guidelines are updated and merged into the current document. INTENDED USERS: All maternity care (most responsible health provider [MRHP]) and paediatric providers; maternity nursing; nurse practitioner; provincial maternity care administrator; medical student; and postgraduate resident year 1-7...
August 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27631497/cd40-expression-in-fibrocytes-is-induced-by-tsh-potential-synergistic-immune-activation
#18
Tünde Mester, Nupur Raychaudhuri, Erin F Gillespie, Hong Chen, Terry J Smith, Raymond S Douglas
CONTEXT: Fibrocytes appear to participate in inflammation and tissue remodeling in patients with thyroid-associated ophthalmopathy (TAO). These patients have increased frequencies of circulating TSH receptor (TSHR)- and CD40-positive fibrocytes, suggesting TSHR and CD40 may play roles in proinflammatory cytokine production, which ultimately leads to orbital inflammation and tissue remodeling. OBJECTIVE: To investigate the potential interactions between the TSHR and CD40 signaling pathways and their roles in IL-6 and TNF-α production...
2016: PloS One
https://www.readbyqxmd.com/read/27622720/evaluating-patient-centered-outcomes-in-clinical-trials-of-procedural-sedation-part-1-efficacy-sedation-consortium-on-endpoints-and-procedures-for-treatment-education-and-research-recommendations
#19
Mark R Williams, Denham S Ward, Douglas Carlson, Joseph Cravero, Franklin Dexter, Jenifer R Lightdale, Keira P Mason, James Miner, John J Vargo, John W Berkenbosch, Randall M Clark, Isabelle Constant, Raymond Dionne, Robert H Dworkin, David Gozal, David Grayzel, Michael G Irwin, Jerrold Lerman, Robert E O'Connor, Pratik Pandharipande, Bob A Rappaport, Richard R Riker, Joseph R Tobin, Dennis C Turk, Rebecca S Twersky, Daniel I Sessler
The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research, established by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership with the US Food and Drug Administration, convened a meeting of sedation experts from a variety of clinical specialties and research backgrounds with the objective of developing recommendations for procedural sedation research. Four core outcome domains were recommended for consideration in sedation clinical trials: (1) safety, (2) efficacy, (3) patient-centered and/or family-centered outcomes, and (4) efficiency...
September 12, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27612658/thyrotropin-and-cd40l-stimulate-interleukin-12-expression-in-fibrocytes-implications-for-pathogenesis-of-thyroid-associated-ophthalmopathy
#20
Tong Wu, Tünde Mester, Shivani Gupta, Fengyuan Sun, Terry J Smith, Raymond S Douglas
BACKGROUND: Increased numbers of bone marrow-derived progenitor cells, known as fibrocytes, populate the peripheral circulation, orbit, and thyroid of patients with Graves' disease (GD). These cells have been implicated in the development of thyroid-associated ophthalmopathy. They can differentiate into myofibroblasts or adipocytes, produce inflammatory cytokines, and remodel tissue. This study sought to determine whether thyrotropin (TSH) and CD40 ligand (CD40L), implicated in the pathogenesis of GD, induce interleukin-12 (IL-12) in human fibrocytes...
December 2016: Thyroid: Official Journal of the American Thyroid Association
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