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https://www.readbyqxmd.com/read/27846035/ibd-live-case-series-case-6-persistent-skin-lesions-in-a-patient-with-crohn-s-disease-you-hear-hoof-beats-and-discover-a-zebra
#1
Dhyan Rajan, Julia B Greer, Miguel D Regueiro, Leonard Baidoo, David G Binion, Hans H Herfarth, Corey A Siegel, Douglas J Hartman, Francis A Farraye, Ioannis E Koutroubakis, Myron H Brand, Emmanuelle D Williams, Alka Goyal, Raymond K Cross
No abstract text is available yet for this article.
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27821172/a-positive-feedback-loop-involving-the-wnt-%C3%AE-catenin-myc-sox2-axis-defines-a-highly-tumorigenic-cell-subpopulation-in-alk-positive-anaplastic-large-cell-lymphoma
#2
Chengsheng Wu, Hai-Feng Zhang, Nidhi Gupta, Abdulraheem Alshareef, Qian Wang, Yung-Hsing Huang, Jamie T Lewis, Donna N Douglas, Norman M Kneteman, Raymond Lai
BACKGROUND: We have previously described the existence of two phenotypically distinct cell subsets in ALK-positive anaplastic large cell lymphoma (ALK + ALCL) based on their differential responsiveness to a Sox2 reporter (SRR2), with reporter-responsive (RR) cells being more tumorigenic and chemoresistant than reporter-unresponsive (RU) cells. However, the regulator(s) of RU/RR dichotomy are not identified. In this study, we aim to delineate the key regulator(s) of RU/RR dichotomy...
November 8, 2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27813347/early-high-intensity-versus-low-intensity-rehabilitation-after-total-knee-arthroplasty-a-randomized-controlled-trial
#3
Michael Bade, Tamara Struessel, Michael Dayton, Jared Foran, Raymond Kim, Todd Miner, Pamela Wolfe, Wendy Kohrt, Douglas Dennis, Jennifer Stevens-Lapsley
OBJECTIVE: The purpose of this study was to examine the safety and efficacy of a high-intensity progressive rehabilitation protocol (HI) beginning 4 days after total knee arthroplasty (TKA) compared to a low-intensity (LI) rehabilitation protocol. METHODS: One hundred sixty-two participants (aged 63±7 years; 89 females) were randomized to either the HI group or LI group after TKA. Key components of the HI intervention were the utilization of progressive resistance exercises and a rapid progression to weight-bearing exercises and activities...
November 3, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27780885/futuretox-iii-bridges-for-translation
#4
Daland R Juberg, Thomas B Knudsen, Miriam Sander, Nancy B Beck, Elaine M Faustman, Donna L Mendrick, John R Fowle, Thomas Hartung, Raymond R Tice, Emmanuel Lemazurier, Richard A Becker, Suzanne Compton Fitzpatrick, George P Daston, Alison Harrill, Ronald N Hines, Douglas A Keller, John C Lipscomb, David Watson, Tina Bahadori, Kevin M Crofton
Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on developing the high throughput risk assessment paradigm and taking the science of in vitro data and in silico models forward to explore the question-what progress is being made to address challenges in implementing the emerging big-data toolbox for risk assessment and regulatory decision-making. This article reports on the outcome of the workshop including 2 examples of where advancements in predictive toxicology approaches are being applied within Federal agencies, where opportunities remain within the exposome and AOP domains, and how collectively the toxicology community across multiple sectors can continue to bridge the translation from historical approaches to Tox21 implementation relative to risk assessment and regulatory decision-making...
October 25, 2016: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/27755273/ibd-live-case-series-case-6
#5
Dhyan Rajan, Julia B Greer, Miguel D Regueiro, Leonard Baidoo, David G Binion, Hans H Herfarth, Corey A Siegel, Douglas J Hartman, Francis A Farraye, Ioannis E Koutroubakis, Myron H Brand, Emmanuelle D Williams, Alka Goyal, Raymond K Cross
No abstract text is available yet for this article.
November 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27733493/canadian-registry-of-implantable-electronic-device-outcomes-surveillance-of-the-riata-lead-under-advisory
#6
Ratika Parkash, Bernard Thibault, Iqwal Mangat, Benoit Coutu, Matthew Bennett, Jeffrey Healey, Atul Verma, Francois Philippon, Roopinder Sandhu, Douglas Cameron, Felix Ayala-Paredes, Laurence Sterns, Vidal Essebag, Teresa Kus, Pablo Nery, Elizabeth Stephenson, Raymond Yee, Derek Exner, Satish Toal, David Birnie, George Wells, Andrew Krahn
BACKGROUND: The Riata lead under advisory has posed a unique clinical scenario where inside-out abrasion results in externalization of conductor cables, with a higher risk of electrical failure. We developed a comprehensive registry to assist with clinical management of this lead. METHODS AND RESULTS: This Canadian registry reports the findings of 3763 (74.2% of all Riata leads in Canada) Riata leads under advisory, with a mean follow-up time of 8.9±1.5 years. The overall electrical failure rate was 5...
October 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/27727233/randomised-open-label-phase-ii-study-of-gemcitabine-with-and-without-imm-101-for-advanced-pancreatic-cancer
#7
Angus G Dalgleish, Justin Stebbing, Douglas J A Adamson, Seema Safia Arif, Paolo Bidoli, David Chang, Sue Cheeseman, Robert Diaz-Beveridge, Carlos Fernandez-Martos, Rob Glynne-Jones, Cristina Granetto, Bartomeu Massuti, Karen McAdam, Raymond McDermott, Andrés J Muñoz Martín, Demetris Papamichael, Roberto Pazo-Cid, Jose M Vieitez, Alberto Zaniboni, Kevin J Carroll, Shama Wagle, Andrew Gaya, Satvinder S Mudan
No abstract text is available yet for this article.
October 11, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27638987/joint-sogc-ccmg-opinion-for-reproductive-genetic-carrier-screening-an-update-for-all-canadian-providers-of-maternity-and-reproductive-healthcare-in-the-era-of-direct-to-consumer-testing
#8
R Douglas Wilson, Isabelle De Bie, Christine M Armour, Richard N Brown, Carla Campagnolo, June C Carroll, Nan Okun, Tanya Nelson, Rhonda Zwingerman, Francois Audibert, Jo-Ann Brock, Richard N Brown, Carla Campagnolo, June C Carroll, Isabelle De Bie, Jo-Ann Johnson, Nan Okun, Melanie Pastruck, Karine Vallée-Pouliot, R Douglas Wilson, Rhonda Zwingerman, Christine Armour, David Chitayat, Isabelle De Bie, Sara Fernandez, Raymond Kim, Josee Lavoie, Norma Leonard, Tanya Nelson, Sherry Taylor, Margot Van Allen, Clara Van Karnebeek
OBJECTIVE: This guideline was written to update Canadian maternity care and reproductive healthcare providers on pre- and postconceptional reproductive carrier screening for women or couples who may be at risk of being carriers for autosomal recessive (AR), autosomal dominant (AD), or X-linked (XL) conditions, with risk of transmission to the fetus. Four previous SOGC- Canadian College of Medical Geneticists (CCMG) guidelines are updated and merged into the current document. INTENDED USERS: All maternity care (most responsible health provider [MRHP]) and paediatric providers; maternity nursing; nurse practitioner; provincial maternity care administrator; medical student; and postgraduate resident year 1-7...
August 2016: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/27631497/cd40-expression-in-fibrocytes-is-induced-by-tsh-potential-synergistic-immune-activation
#9
Tünde Mester, Nupur Raychaudhuri, Erin F Gillespie, Hong Chen, Terry J Smith, Raymond S Douglas
CONTEXT: Fibrocytes appear to participate in inflammation and tissue remodeling in patients with thyroid-associated ophthalmopathy (TAO). These patients have increased frequencies of circulating TSH receptor (TSHR)- and CD40-positive fibrocytes, suggesting TSHR and CD40 may play roles in proinflammatory cytokine production, which ultimately leads to orbital inflammation and tissue remodeling. OBJECTIVE: To investigate the potential interactions between the TSHR and CD40 signaling pathways and their roles in IL-6 and TNF-α production...
2016: PloS One
https://www.readbyqxmd.com/read/27622720/evaluating-patient-centered-outcomes-in-clinical-trials-of-procedural-sedation-part-1-efficacy-sedation-consortium-on-endpoints-and-procedures-for-treatment-education-and-research-recommendations
#10
Mark R Williams, Denham S Ward, Douglas Carlson, Joseph Cravero, Franklin Dexter, Jenifer R Lightdale, Keira P Mason, James Miner, John J Vargo, John W Berkenbosch, Randall M Clark, Isabelle Constant, Raymond Dionne, Robert H Dworkin, David Gozal, David Grayzel, Michael G Irwin, Jerrold Lerman, Robert E O'Connor, Pratik Pandharipande, Bob A Rappaport, Richard R Riker, Joseph R Tobin, Dennis C Turk, Rebecca S Twersky, Daniel I Sessler
The Sedation Consortium on Endpoints and Procedures for Treatment, Education, and Research, established by the Analgesic, Anesthetic, and Addiction Clinical Trial Translations, Innovations, Opportunities, and Networks public-private partnership with the US Food and Drug Administration, convened a meeting of sedation experts from a variety of clinical specialties and research backgrounds with the objective of developing recommendations for procedural sedation research. Four core outcome domains were recommended for consideration in sedation clinical trials: (1) safety, (2) efficacy, (3) patient-centered and/or family-centered outcomes, and (4) efficiency...
September 12, 2016: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/27612658/thyrotropin-and-cd40l-stimulate-interleukin-12-expression-in-fibrocytes-implications-for-pathogenesis-of-thyroid-associated-ophthalmopathy
#11
Tong Wu, Tünde Mester, Shivani Gupta, Fengyuan Sun, Terry J Smith, Raymond S Douglas
BACKGROUND: Increased numbers of bone marrow-derived progenitor cells, known as fibrocytes, populate the peripheral circulation, orbit, and thyroid of patients with Graves' disease (GD). These cells have been implicated in the development of thyroid-associated ophthalmopathy. They can differentiate into myofibroblasts or adipocytes, produce inflammatory cytokines, and remodel tissue. This study sought to determine whether thyrotropin (TSH) and CD40 ligand (CD40L), implicated in the pathogenesis of GD, induce interleukin-12 (IL-12) in human fibrocytes...
October 18, 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27599039/randomised-open-label-phase-ii-study-of-gemcitabine-with-and-without-imm-101-for-advanced-pancreatic-cancer
#12
Angus G Dalgleish, Justin Stebbing, Douglas Ja Adamson, Seema Safia Arif, Paolo Bidoli, David Chang, Sue Cheeseman, Robert Diaz-Beveridge, Carlos Fernandez-Martos, Rob Glynne-Jones, Cristina Granetto, Bartomeu Massuti, Karen McAdam, Raymond McDermott, Andrés J Muñoz Martín, Demetris Papamichael, Roberto Pazo-Cid, Jose M Vieitez, Alberto Zaniboni, Kevin J Carroll, Shama Wagle, Andrew Gaya, Satvinder S Mudan
BACKGROUND: Immune Modulation and Gemcitabine Evaluation-1, a randomised, open-label, phase II, first-line, proof of concept study (NCT01303172), explored safety and tolerability of IMM-101 (heat-killed Mycobacterium obuense; NCTC 13365) with gemcitabine (GEM) in advanced pancreatic ductal adenocarcinoma. METHODS: Patients were randomised (2 : 1) to IMM-101 (10 mg ml(-l) intradermally)+GEM (1000 mg m(-2) intravenously; n=75), or GEM alone (n=35). Safety was assessed on frequency and incidence of adverse events (AEs)...
September 27, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27568816/de-novo-loss-of-function-mutations-in-kiaa2022-are-associated-with-epilepsy-and-neurodevelopmental-delay-in-females
#13
Rachel Webster, Megan T Cho, Kyle Retterer, Francisca Millan, Catherine Nowak, Jessica Douglas, Ayesha Ahmad, Gerald V Raymond, Maria R Johnson, Aurora Pujol, Amber Begtrup, Dianalee McKnight, Orrin Devinsky, Wendy K Chung
Intellectual disability (ID) affects about 3% of the population and has a male gender bias. Of at least 700 genes currently linked to ID, more than 100 have been identified on the X chromosome, including KIAA2022. KIAA2022 is located on Xq13.3 and is expressed in the developing brain. The protein product of KIAA2022, X-linked Intellectual Disability Protein Related to Neurite Extension (XPN), is developmentally regulated and is involved in neuronal migration and cell adhesion. The clinical manifestations of loss-of-function KIAA2022 mutations have been described previously in fifteen males, born from unaffected carrier mothers, but few females...
August 28, 2016: Clinical Genetics
https://www.readbyqxmd.com/read/27550787/the-impact-of-stratification-by-implausible-energy-reporting-status-on-estimates-of-diet-health-relationships
#14
Janet A Tooze, Laurence S Freedman, Raymond J Carroll, Douglas Midthune, Victor Kipnis
The food frequency questionnaire (FFQ) is known to be prone to measurement error. Researchers have suggested excluding implausible energy reporters (IERs) of FFQ total energy when examining the relationship between a health outcome and FFQ-reported intake to obtain less biased estimates of the effect of the error-prone measure of exposure; however, the statistical properties of stratifying by IER status have not been studied. Under certain assumptions, including nondifferential error, we show that when stratifying by IER status, the attenuation of the estimated relative risk in the stratified models will be either greater or less in both strata (implausible and plausible reporters) than for the nonstratified model, contrary to the common belief that the attenuation will be less among plausible reporters and greater among IERs...
August 23, 2016: Biometrical Journal. Biometrische Zeitschrift
https://www.readbyqxmd.com/read/27549013/real-world-assessment-of-acute-left-ventricular-lead-implant-success-and-complication-rates-results-from-the-attain-success-clinical-trial
#15
John D Hummel, Mark A Coppess, Jeffrey S Osborn, Raymond Yee, Jeffrey W H Fung, Ralph Augostini, Shelby Li, Douglas Hine, Jagmeet P Singh
BACKGROUND: Left ventricular lead (LVL) implant success rates have historically ranged between 70.5% and 95.5%. To date, there are few large studies that evaluate LVL implant success utilizing a single family of delivery catheters and leads. The Attain Success study was a prospective nonrandomized multicenter global study with the main objectives of assessing single-system LVL implant success and complication rates. METHODS: Patients undergoing cardiac resynchronization therapy implantation were eligible for enrollment...
November 2016: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/27525633/clavicle-fractures-are-associated-with-arthritis-of-the-glenohumeral-joint-in-a-large-osteological-collection
#16
Douglas S Weinberg, Heather A Vallier, Gregory A Gaumer, Daniel R Cooperman, Raymond W Liu
OBJECTIVES: Recent data has challenged the historical precedent of nonoperative care for many clavicle fractures; clinical and biomechanical studies have shown altered joint-contact forces occur in the glenohumeral joint (GHJ) after fracture and shortening of the clavicle. However, to date, there have been no analyses documenting the long-term effects of these altered shoulder girdle mechanics on the GHJ. METHODS: The clavicles of 2899 cadaveric skeletons were manually inspected for evidence of fracture...
November 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27472056/mutation-of-growth-arrest-specific-8-reveals-a-role-in-motile-cilia-function-and-human-disease
#17
Wesley R Lewis, Erik B Malarkey, Douglas Tritschler, Raqual Bower, Raymond C Pasek, Jonathan D Porath, Susan E Birket, Sophie Saunier, Corinne Antignac, Michael R Knowles, Margaret W Leigh, Maimoona A Zariwala, Anil K Challa, Robert A Kesterson, Steven M Rowe, Iain A Drummond, John M Parant, Friedhelm Hildebrandt, Mary E Porter, Bradley K Yoder, Nicolas F Berbari
Ciliopathies are genetic disorders arising from dysfunction of microtubule-based cellular appendages called cilia. Different cilia types possess distinct stereotypic microtubule doublet arrangements with non-motile or 'primary' cilia having a 9+0 and motile cilia have a 9+2 array of microtubule doublets. Primary cilia are critical sensory and signaling centers needed for normal mammalian development. Defects in their structure/function result in a spectrum of clinical and developmental pathologies including abnormal neural tube and limb patterning...
July 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27407117/standardized-mixed-meal-tolerance-and-arginine-stimulation-tests-provide-reproducible-and-complementary-measures-of-%C3%AE-cell-function-results-from-the-foundation-for-the-national-institutes-of-health-biomarkers-consortium-investigative-series
#18
Sudha S Shankar, Adrian Vella, Ralph H Raymond, Myrlene A Staten, Roberto A Calle, Richard N Bergman, Charlie Cao, Danny Chen, Claudio Cobelli, Chiara Dalla Man, Mark Deeg, Jennifer Q Dong, Douglas S Lee, David Polidori, R Paul Robertson, Hartmut Ruetten, Darko Stefanovski, Maria T Vassileva, Gordon C Weir, David A Fryburg
OBJECTIVE: Standardized, reproducible, and feasible quantification of β-cell function (BCF) is necessary for the evaluation of interventions to improve insulin secretion and important for comparison across studies. We therefore characterized the responses to, and reproducibility of, standardized methods of in vivo BCF across different glucose tolerance states. RESEARCH DESIGN AND METHODS: Participants classified as having normal glucose tolerance (NGT; n = 23), prediabetes (PDM; n = 17), and type 2 diabetes mellitus (T2DM; n = 22) underwent two standardized mixed-meal tolerance tests (MMTT) and two standardized arginine stimulation tests (AST) in a test-retest paradigm and one frequently sampled intravenous glucose tolerance test (FSIGT)...
September 2016: Diabetes Care
https://www.readbyqxmd.com/read/27385684/anatomic-investigation-of-commonly-used-landmarks-for-evaluating-rotation-during-forearm-fracture-reduction
#19
Douglas S Weinberg, Paul J Park, Kaeleen A Boden, Kevin J Malone, Daniel R Cooperman, Raymond W Liu
BACKGROUND: Evaluating rotation during open reduction and internal fixation of a forearm fracture is of paramount importance. In challenging cases, surgeons may utilize radiographic relationships between proximal and distal radial and ulnar landmarks to assess rotational position. However, to our knowledge, limited anatomic data are available to confirm these relationships. METHODS: Six hundred cadaveric radii and ulnae were obtained. Digital representations of the bicipital tuberosity, the radial styloid, the coronoid process, and the ulnar styloid were acquired, and the rotational profiles between respective landmarks were calculated...
July 6, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27376006/remodeling-an-infarcted-heart-novel-hybrid-treatment-with-transmyocardial-revascularization-and-stem-cell-therapy
#20
REVIEW
Jessika Iwanski, Raymond K Wong, Douglas F Larson, Alice S Ferng, Raymond B Runyan, Steven Goldstein, Zain Khalpey
Transmyocardial revascularization (TMR) has emerged as an additional therapeutic option for patients suffering from diffuse coronary artery disease (CAD), providing immediate angina relief. Recent studies indicate that the volume of surgical cases being performed with TMR have been steadily rising, utilizing TMR as an adjunctive therapy. Therefore the purpose of this review is to provide an up-to-date appreciation of the current state of TMR and its future developmental directions on CAD treatment. The current potential of this therapy focuses on the implementation of stem cells, in order to create a synergistic angiogenic effect while increasing myocardial repair and regeneration...
2016: SpringerPlus
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