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Graves eye disease

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https://www.readbyqxmd.com/read/28791473/59-eyes-with-endogenous-endophthalmitis-causes-outcomes-and-mortality-in-a-danish-population-between-2000-and-2016
#1
Søren Solborg Bjerrum, Morten la Cour
BACKGROUND: To study the epidemiology of patients with endogenous endophthalmitis in Denmark. MATERIAL AND METHODS: Retrospective and prospective case series of 59 eyes in patients with endogenous endophthalmitis in Denmark between 2000 and 2016. RESULTS: The age of the patients ranged from 28 to 90 years with a median of 66 years. Sixty-two percent of the eyes had a final VA (visual acuity) ≤ 0.1 while 8% had a final VA ≥ 1.0. Positive cultures were obtained in 51% of the cases from the blood and in 43% from the vitreous...
August 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28770897/typical-graves-ophthalmopathy-in-primary-hypothyroidism
#2
Zareen Kiran, Owais Rashid, Najmul Islam
Graves ophthalmopathy (GO) usually occurs in a close temporal relationship with hyperthyroidism. It is rare in patients with normal thyroid function (euthyroid GO) and in patients with hypothyroid forms of thyroid autoimmune diseases (hypothyroid GO). We report a 52-years old man presenting in our endocrine clinic with diagnosed primary hypothyroidism 3 months back during evaluation for glaucoma. He was later referred by an ophthalmologist to exclude Grave's eye disease, where he had presented with chief complaints of bilateral prominent eyes...
July 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28750432/hyperthyroidism-in-patients-with-graves-ophthalmopathy-and-thyroidal-skeletal-and-eye-muscle-specific-type-2-deiodinase-enzyme-activities
#3
Ildikó Molnár, József A Szentmiklósi, Éva Somogyiné-Vári
Graves' ophthalmopathy is characterized by hyperthyroidism, which is associated with higher serum T3 levels than T4 due to deiodinase enzymes.The effect of Graves' patient's sera (n=52) with elevated thyroid hormone and TSH receptor or thyroid peroxidase antibody (anti-TPO) levels was investigated on thyroidal, skeletal and eye muscle type 2 deiodinase enzyme (DII) activities. DII activities were measured with (125)I-T4 substrate, while thyroid hormone and antibody levels with immunoassays.In Graves' ophthalmopathy, sera with elevated FT4 or FT3 levels reduced DII activites remarkably in all tissue fractions...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28748990/-clinical-features-of-patients-with-basedow-graves-disease-seen-at-a-university-hospital
#4
Alejandra Lanas, Patricia Díaz, Daniela Eugenin, Franco González, Pía Cid, Francisco Cordero, Verónica Araya, Claudio Liberman, Marcela Barberan, Patricio Gac, Neil Saldías, Pedro Pineda
BACKGROUND: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. AIM: To describe the clinical features of patients with BGD seen at a university hospital. MATERIAL AND METHODS: Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28741406/balanced-endoscopic-medial-and-transcutaneous-lateral-orbital-decompression-in-graves-orbitopathy
#5
Estefanía Hernández-García, J Javier San-Román, Ramón González, Araceli Nogueira, Ignacio Genol, Bazil Stoica, Nicolás Toledano, Guillermo Plaza
BACKGROUND: To determine the clinical outcomes and morbidity of endoscopic medial wall combined with transcutaneous lateral orbital wall decompression in Graves' orbitopathy. METHODOLOGY: A retrospective noncomparative case series of patients who underwent surgical decompression for Graves' orbitopathy at Hospital Universitario de Fuenlabrada between 2004 and 2014 was performed. We reviewed the patients' charts and analyzed before and after the decompression, the visual acuity (Snellen chart), optic nerve compression (fundoscopy and optic coherence tomography), exophthalmometry (Hertel measurement), ocular motility, diplopia, eyelid surgery needed after decompression and its possible complications...
July 25, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28727542/single-session-high-intensity-focused-ultrasound-treatment-for-persistent-or-relapsed-graves-disease-preliminary-experience-in-a-prospective-study
#6
Brian Hung-Hin Lang, Yu-Cho Woo, Ian Yat-Hin Wong, Keith Wan-Hang Chiu
Purpose To evaluate the safety and efficacy of ultrasonography (US)-guided high-intensity focused ultrasound (HIFU) ablation as a treatment for medically refractory Graves disease (GD). Materials and Methods After ethics approval, a prospective trial (NCT02685514) was performed from November 2015 to February 2016. Thirty patients underwent ablation of the entire right and left thyroid lobes, with areas near the tracheal-esophageal groove and common carotid artery left unablated. Serum thyroid-stimulating hormone (TSH), free T4 (FT4), antithyroid autoantibodies, and TSH receptor (TSHR) antibody levels were evaluated afterward, and US color Doppler, US volumetry, and eye assessment were performed...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28700384/update-on-graves-disease-advances-in-treatment-of-mild-moderate-and-severe-thyroid-eye-disease
#7
REVIEW
Diego Strianese
PURPOSE OF REVIEW: To report the most recent therapeutic advances of thyroid eye disease (TED) and offer general recommendations for management of TED. RECENT FINDINGS: Treatment of Graves ophthalmopathy is traditionally based on the use of high doses of corticosteroids and/or radiotherapy (RT) to decrease the activity of the disease, with the subsequent proptosis, strabismus and eyelid deformites treated with different surgical procedures. In recent years, the evidence that oxidative stress plays a relevant role in exacerbating TED severity has encouraged the use of antioxydative agents such as selenium, which has shown a capacity in limiting the disease progression...
September 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28606272/-progression-of-the-pathogenesis-of-thyroid-associated-ophthalmopathy
#8
L Wang, J M Ma
Thyroid associated ophthalmopathy (TAO) is a common complication of Graves' disease (GD). The clinical manifestations are mainly swelling and retracted eyelid, protopsis and limited eye movements, and optic neuropathy can be seen in severe cases. The mechanism of TAO is not yet clear. A large number of studies have found that the disorders of autoimmunity play an important role in TAO, while genetic factors, oxidative stress, and environmental factors such as smoking participate in it. Therefore, we consult a large number of studies and expound the pathogenesis from the aspects of genetic susceptibility, immune mechanism, oxidative stress, and the effects of smoking to provide referrences for clinical associated studies...
June 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28540010/changes-in-choroidal-perfusion-after-orbital-decompression-surgery-for-graves-ophthalmopathy
#9
Narieman Nik, Amelia Fong, Marianna Derdzakyan, Chrysavgi Adamopoulou, Adam Sise, Aziz Khanifar, Reginald Sanders
PURPOSE: To assess choroidal perfusion before and after orbital decompression surgery in patients with Graves' ophthalmopathy. METHODS: In this interventional case series, surgical decompression for optic nerve compromise was performed on four eyes of three patients with Graves' disease. Complete ophthalmic examination including visual acuity, color vision, and intraocular pressure assessment were done pre- and postoperatively. High-speed indocyanine green angiography was performed prior to surgery and was repeated one year after surgery...
April 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/28467880/teprotumumab-for-thyroid-associated-ophthalmopathy
#10
RANDOMIZED CONTROLLED TRIAL
Terry J Smith, George J Kahaly, Daniel G Ezra, James C Fleming, Roger A Dailey, Rosa A Tang, Gerald J Harris, Alessandro Antonelli, Mario Salvi, Robert A Goldberg, James W Gigantelli, Steven M Couch, Erin M Shriver, Brent R Hayek, Eric M Hink, Richard M Woodward, Kathleen Gabriel, Guido Magni, Raymond S Douglas
BACKGROUND: Thyroid-associated ophthalmopathy, a condition commonly associated with Graves' disease, remains inadequately treated. Current medical therapies, which primarily consist of glucocorticoids, have limited efficacy and present safety concerns. Inhibition of the insulin-like growth factor I receptor (IGF-IR) is a new therapeutic strategy to attenuate the underlying autoimmune pathogenesis of ophthalmopathy. METHODS: We conducted a multicenter, double-masked, randomized, placebo-controlled trial to determine the efficacy and safety of teprotumumab, a human monoclonal antibody inhibitor of IGF-IR, in patients with active, moderate-to-severe ophthalmopathy...
May 4, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28458939/isotretinoin-as-a-possible-environmental-trigger-to-autoimmunity-in-genetically-susceptible-patients
#11
Jocelyn Nugroho, Bahareh Schweiger
Introduction. Isotretinoin is commonly used to treat cystic acne. Definitive mechanisms of action for isotretinoin are not known though despite many side effects having been documented. Various case reports have noted autoimmune diseases succeeding isotretinoin treatment. Case Report. A 16-year-old female presents with symptoms of tremors, lack of focus, sleeplessness, emotional liability, bulging eyes, loose stools, heat intolerance, and missed menstrual periods. Symptoms manifested shortly after the patient finished a course of oral isotretinoin treatment for acne...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28447363/tobacco-packaging-design-for-reducing-tobacco-use
#12
REVIEW
Ann McNeill, Shannon Gravely, Sara C Hitchman, Linda Bauld, David Hammond, Jamie Hartmann-Boyce
BACKGROUND: Tobacco use is the largest single preventable cause of death and disease worldwide. Standardised tobacco packaging is an intervention intended to reduce the promotional appeal of packs and can be defined as packaging with a uniform colour (and in some cases shape and size) with no logos or branding, apart from health warnings and other government-mandated information, and the brand name in a prescribed uniform font, colour and size. Australia was the first country to implement standardised tobacco packaging between October and December 2012, France implemented standardised tobacco packaging on 1 January 2017 and several other countries are implementing, or intending to implement, standardised tobacco packaging...
April 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28433126/neonatal-graves-eye-disease
#13
Kira L Segal, Christine C Nelson
No abstract text is available yet for this article.
May 2017: Ophthalmology
https://www.readbyqxmd.com/read/28387769/-99-tc-m-octreotide-scintigraphy-and-serum-eye-muscle-antibodies-in-evaluation-of-active-thyroid-associated-ophthalmopathy
#14
B Sun, Z Zhang, C Dong, Y Zhang, C Yan, S Li
PurposeAs an autoimmune inflammatory disorder, active thyroid-associated ophthalmopathy (TAO) is managed optimally by immunosuppression. In this study, we aimed to evaluate octreotide scintigraphy and the level of serum extraocular muscle antibodies in TAO activity.Patients and methodsThis prospective study comprised 304 patients with active TAO (the clinical activity score; CAS≥3), 73 with inactive TAO (CAS<3), 128 with Graves' disease (GD) without ophthalmopathy, and 100 healthy subjects. Moderate-to-severe active TAO patients (CAS≥5) received intravenous injection of methylprednisolone; mild active patients (3≤CAS≤4) received periocular injection of triamcinolone acetonide...
May 2017: Eye
https://www.readbyqxmd.com/read/28319174/simultaneous-induction-of-graves-hyperthyroidism-and-graves-ophthalmopathy-by-tshr-genetic-immunization-in-balb-c-mice
#15
Nan Xia, Xiaozhen Ye, Xiaohao Hu, Shiyu Song, Hui Xu, Mengyuan Niu, Hongwei Wang, Jian Wang
BACKGROUND: Graves' disease is the most common form of autoimmune thyroid disorder, characterized by hyperthyroidism due to circulating autoantibodies. To address the pathological features and establish a therapeutic approach of this disease, an animal model carrying the phenotype of Graves' disease (GD) in concert with Graves' Ophthalmopathy (GO) will be very important. However, there are no ideal animal models that are currently available. The aim of the present study is to establish an animal model of GD and GO disease, and its pathological features were further characterized...
2017: PloS One
https://www.readbyqxmd.com/read/28255299/selenium-and-thyroid-disease-from-pathophysiology-to-treatment
#16
REVIEW
Mara Ventura, Miguel Melo, Francisco Carrilho
Introduction. Selenium is a micronutrient embedded in several proteins. In adults, the thyroid is the organ with the highest amount of selenium per gram of tissue. Selenium levels in the body depend on the characteristics of the population and its diet, geographic area, and soil composition. In the thyroid, selenium is required for the antioxidant function and for the metabolism of thyroid hormones. Methods. We performed a review of the literature on selenium's role in thyroid function using PubMed/MEDLINE...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28222462/decreased-frequencies-of-peripheral-blood-cd4-cd25-cd127-foxp3-in-patients-with-graves-disease-and-graves-orbitopathy-enhancing-effect-of-insulin-growth-factor-1-on-treg-cells
#17
Przemyslaw Pawlowski, Kamil Grubczak, Jerzy Kostecki, Elzbieta Ilendo-Poskrobko, Marcin Moniuszko, Malgorzata Pawlowska, Robert Rejdak, Joanna Reszec, Janusz Mysliwiec
Graves' orbitopathy (GO) is characterized by orbital T cell infiltration. We evaluated the regulatory T (Treg) cell fractions induced with IGF-1 in Graves' disease (GD) with and without GO. Peripheral blood mononuclear cells (PBMCs) were obtained from 13 patients with GD without eye manifestations; 10 patients with active GO; and 12 patients with nodular goiter (NG). All the patients from GD, GO, and NG were subclinical hyperthyroid. We analyzed the expression of Treg cell markers (CD4, CD25, CD127(-), Foxp3) on T cells and their ability to respond to IGF-1 stimulation...
March 2017: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/28181061/changing-trend-in-referral-to-secondary-care-specialist-thyroid-eye-disease-clinic-following-the-amsterdam-declaration
#18
Annika S Quinn, Leticia R Dujardin, Bridget Knight, James Benzimra, Anthony G Quinn, Bijay Vaidya
INTRODUCTION: Early diagnosis and treatment of thyroid eye disease (TED) improves outcomes. Previous studies have highlighted delays in diagnosis and referral to specialist centres. The Amsterdam declaration (2009) aimed to halve the time from presentation to diagnosis and from diagnosis to referral to a specialist centre in five years. A recent study from the European group on Graves' orbitopathy tertiary centres showed a trend for earlier referral of patients to the centres. It is unknown whether similar improvements are occurring in secondary care hospitals in the UK...
February 8, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28133945/objective-and-subjective-outcomes-of-strabismus-surgery-in-graves-orbitopathy-a-prospective-multicentre-study
#19
Hinke Marijke Jellema, Peerooz Saeed, Ilse Mombaerts, Peter J Dolman, Jim Garrity, Mike Kazim, Elona Dhrami-Gavazi, Christopher Lyons, Pythia Nieuwkerk, Maarten P Mourits
PURPOSE: To assess the change and interrelationship of the field of binocular single vision (BSV) and the quality of life (QoL), tested with two different tools, after one or two strabismus surgeries in patients with Graves' orbitopathy (GO). METHODS: Prospectively, consecutive patients with GO who were scheduled for their first strabismus surgery were recruited from five centres specialized in the treatment of GO. One week preoperatively and 3 months after the last operation, a full ophthalmic and orthoptic examination was performed...
January 30, 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/28078992/smoking-and-eye-pathologies-a-systemic-review-part-ii-retina-diseases-uveitis-optic-neuropathies-thyroid-associated-orbitopathy
#20
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health. AIM: The analysis of influence of tobacco smoking on retina diseases, uveitis, optic neuropathies, and thyroidassociated orbitopathy in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, covering the years 2000-2016. RESULTS: In adults, tobacco smoking is a strong risk factor for age-related macular degeneration, polypoidal choroidal vasculopathy, uveitis and inflamed cystoid macular edema as well as Grave`s ophthalmopathy...
2017: Current Pharmaceutical Design
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