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https://www.readbyqxmd.com/read/29772543/functional-diagnostics-for-thyrotropin-hormone-receptor-autoantibodies-bioassays-prevail-over-binding-assays
#1
Simon David Lytton, Anke Schluter, Paul J Banga
Autoantibodies to the thyrotropin hormone receptor (TSH-R) are directly responsible for the hyperthyroidism in Graves' disease and mediate orbital manifestations in Graves' orbitopathy (otherwise known as thyroid eye disease). These autoantibodies are heterogeneous in their function and collectively referred to as TRAbs. Measurement of TRAbs is clinically important for diagnosis of a variety of conditions and different commercial assays with high sensitivity and specificity are available for diagnostic purposes...
June 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/29771756/thyrotropin-receptor-antibodies-an-overview
#2
Anupam Kotwal, Marius Stan
PURPOSE: Thyroid autoimmunity affects approximately 5% of the population, and its investigation relies heavily on the use of autoantibodies. Thyroid stimulating hormone receptor (TSHR) autoantibodies (TRAb) play a central role in the evaluation of Graves disease (GD), Graves ophthalmopathy (GO) and pretibial myxedema (PTM). However, there is still controversy regarding overall TRAb assay diagnostic accuracy and their prognostic utility. METHODS: We reviewed and analyzed the literature reporting TRAb assays and their clinical utility...
May 2, 2018: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29744075/graves-orbitopathy-after-allogeneic-bone-marrow-transplantation-in-a-patient-with-fanconi-anemia-side-effect-of-alemtuzumab-therapy
#3
Luminita Nicoleta Cima, Ioana Maria Lambrescu, Lavinia Stejereanu, Anca Colita, Reuven Or, Simona Fica
A few cases of thyroid eye disease following alemtuzumab therapy have been described in patients with multiple sclerosis. Our patient is the first case of Graves' orbitopathy after alemtuzumab conditioning for hematopoietic stem cell transplantation.
May 2018: Clinical Case Reports
https://www.readbyqxmd.com/read/29738594/bilateral-asymmetric-keratoconus-induced-by-thyrotoxicosis-with-long-term-stability-after-corneal-cross-linking
#4
Ramon Lee, Ahmed El-Massry, Youssef El-Massry, J Bradley Randleman
PURPOSE: To present a case of bilateral, asymmetric keratoconus presenting unilaterally after partial thyroidectomy with delayed presentation in the second eye after thyrotoxicosis, with disease stabilization following corneal cross-linking (CXL). METHODS: Case report and literature review. RESULTS: A 17-year-old girl with a history of Graves' disease underwent partial thyroidectomy without thyroid hormone replacement therapy with normal baseline ophthalmic examination of corrected distance visual acuity (CDVA) of 20/20 and no manifest astigmatism in either eye...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29738593/bilateral-keratoconus-induced-by-secondary-hypothyroidism-after-radioactive-iodine-therapy
#5
Ramon Lee, Farhad Hafezi, J Bradley Randleman
PURPOSE: To present a case of new-onset, bilateral, rapidly progressive keratoconus induced by secondary hypothyroidism after radioactive iodine therapy during the sixth decade of life that was successfully treated with corneal cross-linking. METHODS: Case report and literature review. RESULTS: A 53-year-old woman with no ocular complaints but with a history of Graves' disease and thyrotoxicosis was treated with radioactive iodine therapy and oral levothyroxine for secondary acquired hypothyroidism 3 years prior...
May 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29732037/prevalence-and-severity-of-ocular-involvement-in-graves-disease-according-to-sex-and-age-a-clinical-study-from-babol-iran
#6
Sara Gharib, Zoleika Moazezi, Mohammad Ali Bayani
Background: Thyroid-associated eye disease (TED), previously known as Graves' ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves' disease according to sex, age and duration in northern Iran. Methods: Between April 2011 and March 2012, 105 patients with Graves' disease, underwent ophthalmic examination, including ocular motility, exophthalmometry, intraocular pressure (IOP), slit lamp and fundoscopy...
2018: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29729448/quality-of-life-and-neuropsychiatric-disorders-in-patients-with-graves-orbitopathy-current-concepts
#7
REVIEW
Alice Bruscolini, Marta Sacchetti, Maurizio La Cava, Marcella Nebbioso, Angela Iannitelli, Adele Quartini, Alessandro Lambiase, Massimo Ralli, Armando de Virgilio, Antonio Greco
Graves' disease (GD) is an autoimmune chronic thyroiditis frequently associated with development of Graves' orbitopathy (GO) characterized by proptosis, strabismus, impairment of visual function, ocular surface inflammation and dry eye. As consequence, patients with GO experience impairment of quality of life and social function and could develop a neurobehavioral syndrome, ranging from anxious to depressive or psychotic disorders. To date, the pathogenic mechanism underlying neuropsychiatric disorders in patients with GD has not been clearly understood...
May 2, 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29719374/clinical-course-of-thyroid-function-and-thyroid-associated-ophthalmopathy-in-patients-with-euthyroid-graves-disease
#8
Nami Suzuki, Jaeduk Yoshimura Noh, Toshiaki Kameda, Ai Yoshihara, Hidemi Ohye, Miho Suzuki, Masako Matsumoto, Yo Kunii, Kenji Iwaku, Natsuko Watanabe, Koji Mukasa, Ai Kozaki, Toshu Inoue, Kiminori Sugino, Koichi Ito
Background: Euthyroid Graves' disease (EGD) is a rare condition defined as the presence of thyroid-associated ophthalmopathy (TAO) in patients with normal thyroid function. Due to the rarity of this disease, only a limited number of studies and case reports are available for further evaluation of the characteristics of the disease. The aim of this study was to examine the changes in the thyroid function, thyrotropin receptor antibodies (TRAb) and eye symptoms, and then determine whether TRAb is related to TAO in EGD patients...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29671250/measurement-properties-of-thypro-short-form-thypro-39-for-use-in-chinese-patients-with-benign-thyroid-diseases
#9
Carlos K H Wong, Edmond P H Choi, Y C Woo, Brian H H Lang
PURPOSE: To evaluate the validity and reliability of a newly-translated Thyroid-specific Patient-Reported Outcome short-form (ThyPRO-39) instrument for ethnic-Chinese patients suffering from benign thyroid diseases. METHODS: The translation and cross-cultural adaptation of the English ThyPRO-39 were performed using the double forward translation, reconciliation, single backward translation, and cognitive debriefing, followed by a panel review. Cross-sectional data of 308 patients with benign thyroid diseases were utilized for this psychometric evaluation of ThyPRO-39 instrument...
April 18, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29670918/management-of-patients-with-graves-disease-and-orbital-involvement-role-of-spectral-domain-optical-coherence-tomography
#10
Alice Bruscolini, Maurizio La Cava, Magda Gharbiya, Marta Sacchetti, Lucia Restivo, Chiara Nardella, Marco Marenco, Alessandro Lambiase
Purpose: To investigate the role of choroidal thickness evaluation with spectral domain optical coherence tomography (SDOCT) and enhanced depth imaging (EDI) technique in the management of patients with Graves' disease and orbitopathy (GO). Methods: Thirty-six eyes of 18 patients with GO and 36 eyes of 18 age-matched control subjects were included in this retrospective observational study. All the subjects underwent a complete ophthalmological evaluation, including clinical activity score (CAS) and exophthalmometry...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29652204/low-dose-rituximab-for-active-moderate-to-severe-graves-orbitopathy-resistant-to-conventional-treatment
#11
Laurence Du Pasquier-Fediaevsky, Stefan Andrei, Michel Berche, Laurence Leenhardt, Emmanuel Héron, Sébastien Rivière
PURPOSE: To report low-dose rituximab effect in Graves' orbitopathy (GO) resistant to conventional treatment. METHODS: Retrospective analysis of medical records, filled in according to the European Group on Graves' Orbitopathy (EUGOGO) standards, of patients with active moderate-to-severe GO who received low-dose rituximab after failure of conventional treatment. Efficacy was defined by a decrease of the clinical activity score of 2 points or <4/10. RESULTS: Among 219 patients treated between 2012 and 2016 by pulse methylprednisolone, possibly followed by oral steroids and/or orbital radiotherapy, 15 (6...
April 13, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29618929/original-endoscopic-orbital-decompression-of-lateral-wall-through-hairline-approach-for-graves-ophthalmopathy-an-innovation-of-balanced-orbital-decompression
#12
Yi Gong, Jiayang Yin, Boding Tong, Jingkun Li, Jiexi Zeng, Zhongkun Zuo, Fei Ye, Yongheng Luo, Jing Xiao, Wei Xiong
Background: Orbital decompression is an important surgical procedure for treatment of Graves' ophthalmopathy (GO), especially in women. It is reasonable for balanced orbital decompression of the lateral and medial wall. Various surgical approaches, including endoscopic transnasal surgery for medial wall and eye-side skin incision surgery for lateral wall, are being used nowadays, but many of them lack the validity, safety, or cosmetic effect. Patients and methods: Endoscopic orbital decompression of lateral wall through hairline approach and decompression of medial wall via endoscopic transnasal surgery was done to achieve a balanced orbital decompression, aiming to improve the appearance of proptosis and create conditions for possible strabismus and eyelid surgery afterward...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29594055/occurrence-of-graves-orbitopathy-and-graves-hyperthyroidism-after-a-trauma-to-the-eye
#13
Elena Sabini, Ilaria Ionni, Roberto Rocchi, Paolo Vitti, Claudio Marcocci, Michele Marinò
Background: Graves' orbitopathy (GO) is believed to be the consequence of autoimmunity against antigens that are present both in the thyroid and orbital tissues. Massive release of thyroid antigens causes the appearance or deterioration of GO in patients with Graves' hyperthyroidism (GH), as it occurs following radioiodine treatment. In theory, a similar release of autoantigens may occur at the eye level, for example due to an orbital trauma or surgical manipulation. To our knowledge, this is the first report of a case of de novo appearance of GO and then GH after an eye trauma, possibly reflecting spreading of autoantigens and activation of the immune system against shared orbital and thyroid antigens...
January 2018: European Thyroid Journal
https://www.readbyqxmd.com/read/29574428/thyrotoxic-crisis-as-an-acute-clinical-presentation-in-a-child
#14
Adam Bonfield, Savitha Shenoy
A previously well, 4-year-old girl presented with a 4-6 weeks' history of increased appetite, weight loss, tiredness, sleep difficulty, excessive sweating, swelling in the neck and new-onset 'prominent, protruding eyes.' Family history revealed paternal grandmother receiving treatment for hyperthyroidism. Clinical assessment demonstrated features of thyrotoxicosis (tachycardia, warm peripheries, small smooth goitre with no nodules, exophthalmos). TFT (Free T4=101 pmol/L, thyroid-stimulating hormone <0...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29546048/changes-of-nicotinamide-phosphoribosyltransferase-expressions-in-thyroid-glands-of-patients-with-different-thyroid-pathologies
#15
Nadia Sawicka-Gutaj, Mirosław Andrusiewicz, Agata Czarnywojtek, Joanna Waligórska-Stachura, Maciej Biczysko, Jerzy Skrobisz, Jerzy Sowiński, Marek Ruchała
Purpose: Our aim was to analyze NAMPT expression in thyroid tissue derived from patients with Graves' disease with (GD) and without (GO) orbitopathy, patients with toxic nodular goiters (TNG) and thyroid cancers (TC), and healthy controls. Methods: 153 thyroid tissue samples of consecutive patients who underwent thyroidectomy were collected. Previous therapy with steroids was an exclusion criterion. We collected clinicopathological data of all subjects and we assessed NAMPT expression using qPCR...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29482520/extraocular-muscle-repositioning-as-the-last-therapeutic-option-for-a-patient-with-a-severe-course-of-graves-ophthalmopathy-a-case-report
#16
Andrea Rau, Matthias Klopfer, Niklas Rommel, Mechthild Rau-Fornefeld, Andreas Kolk
BACKGROUND: Graves' disease is a common autoimmune inflammatory condition of the thyroid. About one in four of affected patients also develop orbital symptoms like exophthalmos, proptosis and diplopia - called Graves' Ophthalmopathy. Not all patients respond well to the standard therapy of systemic glucocorticoid administration. The inflammatory swelling of the intraorbital muscles can lead to pressure-induced damage of the optic nerve. Orbital decompression surgery is a therapeutic option for these patients with varying success...
February 27, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29422752/epidemiology-and-clinical-features-of-thyroid-associated-orbitopathy-in-accra
#17
Edith Mawunyo Ackuaku-Dogbe, Josephine Akpalu, Benjamin Abaidoo
PURPOSE: Thyroid-associated orbitopathy (TAO), a clinical manifestation of Graves' disease, is an autoimmune disorder of the orbital and periorbital tissue. Data on the epidemiology and clinical presentation of TAO in Africa are generally scarce and unavailable in Ghana. We investigated the epidemiology and clinical features of TAO among patients with thyroid disorders attending the Korle Bu Teaching Hospital, Accra. SUBJECTS AND METHODS: This was a descriptive cross-sectional study of patients diagnosed with thyroid disorders which was conducted at the endocrine and orbital clinics of the Korle Bu Teaching Hospital...
October 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/29409479/orbital-radiotherapy-plus-three-wall-orbital-decompression-in-a-patient-with-rare-ocular-manifestations-of-thyroid-eye-disease-case-report
#18
Shuo Zhang, Yang Wang, Sisi Zhong, Xingtong Liu, Yazhuo Huang, Sijie Fang, Ai Zhuang, Yinwei Li, Jing Sun, Huifang Zhou, Xianqun Fan
BACKGROUND: Thyroid eye disease (TED) is a debilitating autoimmune orbital disease that is often a result of Graves' disease. Dysthyroid optic neuropathy (DON) is a rare but sight-threatening manifestation of TED with therapeutic challenges that can potentially lead to visual loss. CASE PRESENTATION: A 74-year-old man experienced active TED with extremely severe redness and swelling of the conjunctiva, loss of visual acuity and exacerbation of disfiguring proptosis...
February 6, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29388175/early-stage-graves-disease-is-uniformly-accompanied-by-orbital-immune-activity-even-in-patients-who-fail-to-develop-orbithopathy-during-follow-up
#19
Eszter Berta, Miklós Bodor, László Galuska, György Paragh, Annamária Erdei, Annamária Gazdag, Bernadett Ujhelyi, Ervin Berényi, Mónika Katkó, Andrea Gazsó, Endre V Nagy
PURPOSE: Graves' orbitopathy (GO) is a complication of Graves' disease (GD), the development of which cannot be predicted at the time of diagnosis of GD. Our aims were (i) to test if orbital 99m Tc-labelled diethylenetriamine pentaacetic acid single-photon emission computer tomography (DTPA SPECT) can predict development of GO later during the course of the disease and (ii) to study whether orbital immune activity can be detected in GD patients who do not develop GO during follow-up. METHODS: Fifty-four orbits of 27 patients with newly diagnosed GD were entered into the case-control study...
January 31, 2018: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/29372654/functional-tsh-receptor-antibodies-in-children-with-autoimmune-thyroid-diseases
#20
Karolina Stożek, Artur Bossowski, Katarzyna Ziora, Anna Bossowska, Małgorzata Mrugacz, Anna Noczyńska, Mieczysław Walczak, Elżbieta Petriczko, Beata Pyrżak, Anna Kucharska, Mieczysław Szalecki, Tanja Diana, George J Kahaly
INTRODUCTION: The diagnostic value of the level of TSH receptor antibodies (TSHR-Ab) in the population of children with autoimmune thyroid diseases (AITDs) is still unknown. The aim of this cross-sectional study was to investigate the prevalence of TSHR-Ab in a paediatric cohort with AITD and healthy controls. MATERIALS AND METHODS: A total of 240 serum samples were obtained from 205 patients with AITD, type 1 diabetes (T1D), juvenile arthritis (JA), and healthy controls (C)...
March 2018: Autoimmunity
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