keyword
https://read.qxmd.com/read/38233878/tacrolimus-versus-mycophenolate-for-autoimmune-hepatitis-patients-with-incomplete-response-on-first-line-therapy-tailor-study-a-study-protocol-for-a-phase-iii-open-label-multicentre-randomised-controlled-trial
#21
JOURNAL ARTICLE
Anna E C Stoelinga, Maarten E Tushuizen, Wilbert B van den Hout, Mar D M Rodriguez Girondo, Elsemieke S de Vries, Amar D Levens, Dirk-Jan A R Moes, Tom J G Gevers, Suzanne van der Meer, Hans T Brouwer, Hendrik J M de Jonge, Ynte S de Boer, Ulrich H W Beuers, Adriaan J van der Meer, Aad P van den Berg, Maureen M J Guichelaar, Joost P H Drenth, Bart van Hoek
BACKGROUND: Autoimmune hepatitis (AIH) is a rare, chronic inflammatory disease of the liver. The treatment goal is reaching complete biochemical response (CR), defined as the normalisation of aspartate and alanine aminotransferases and immunoglobulin gamma. Ongoing AIH activity can lead to fibrosis and (decompensated) cirrhosis. Incomplete biochemical response is the most important risk factor for liver transplantation or liver-related mortality. First-line treatment consists of a combination of azathioprine and prednisolone...
January 17, 2024: Trials
https://read.qxmd.com/read/38229798/intermittent-or-sequential-topical-tacrolimus-in-atopic-dermatitis-systematic-review-and-meta-analysis
#22
REVIEW
Sandipan Dhar, Abhishek De, Abhijit Saha, Kruttika R Chitnis, Abhishek Mane, Dhiraj Dhoot, Hanmant Barkate
Topical calcineurin inhibitors (TCIs) and topical corticosteroids (TCS) are the mainstays of flare management for atopic eczema or atopic dermatitis (AD). Tacrolimus (an immunomodulator), belongs to the class of calcineurin inhibitors, with promising efficacy in AD. We performed this systematic review to obtain an up-to-date coverage map of controlled clinical trials of sequential or intermittent treatments with TCI as a therapeutic intervention for AD. Articles of interest were retrieved from PubMed, Google Scholar, and EMBASE published between between January 2000 and March 2023...
December 2023: Curēus
https://read.qxmd.com/read/38226937/immunosuppressive-and-immunomodulating-therapy-for-atopic-dermatitis-in-pregnancy-an-appraisal-of-the-literature
#23
JOURNAL ARTICLE
Aska Drljevic-Nielsen, Sofine Heilskov, Mette S Deleuran, Christian Vestergaard
Atopic dermatitis (AD) is the most common dermatological diagnosis during pregnancy. Treatment of AD during pregnancy can be challenging, due to the unpredictable course and the fact that the therapy needs to be safe for both the mother and the fetus. Here we present an up-to-date appraisal of the literature on the treatment options available for AD in patients planning pregnancy, during pregnancy, and during breastfeeding. All patients with AD are recommended to supplement any medical treatment with daily applications of emollients...
January 16, 2024: Italian journal of dermatology and venereology
https://read.qxmd.com/read/38226116/long-term-clinical-outcome-of-tacrolimus-skin-ointment-0-03-for-the-treatment-of-vernal-keratoconjunctivitis-a-quasi-experimental-study
#24
JOURNAL ARTICLE
Warda Ali, Saad Alam Khan, Fahim Ullah Khan, Shama Khan, Wajid A Khan, Rabeeah Zafar, Muhammad A Moqeet
Background Vernal keratoconjunctivitis (VKC) is an allergic conjunctival inflammation with severe ocular complications if left untreated. The current management regimen is plagued with adverse effects, long-term problems, and clinical relapses. Tacrolimus offers an alternative treatment option, and long-term studies are needed to determine its efficacy. Methods A two-year follow-up based study was conducted on moderate to severe VKC patients, who were prescribed tacrolimus skin ointment. The 5-5-5 exacerbation scale was used for the monitoring and grading severity of the disease...
December 2023: Curēus
https://read.qxmd.com/read/38225772/treatment-of-hypopigmented-burn-hypertrophic-scars-with-short-term-topical-tacrolimus-does-not-lead-to-repigmentation
#25
JOURNAL ARTICLE
Esteban A Molina, Taryn E Travis, Lou'ay Hussein, Mary A Oliver, John W Keyloun, Lauren T Moffatt, Jeffrey W Shupp, Bonnie C Carney
OBJECTIVES: Dyschromia is an understudied aspect of hypertrophic scar (HTS). The use of topical tacrolimus has successfully shown repigmentation in vitiligo patients through promotion of melanogenesis and melanocyte proliferation. It was hypothesized that HTSs treated with topical tacrolimus would have increased repigmentation compared to controls. METHODOLOGY: Full-thickness burns in red Duroc pigs were either treated with excision and meshed split-thickness skin grafting or excision and no grafting, and these wounds formed hypopigmented HTSs (n = 8)...
February 2024: Lasers in Surgery and Medicine
https://read.qxmd.com/read/38183743/syk-blnk-nf-%C3%AE%C2%BAb-signaling-promotes-pancreatic-injury-induced-by-tacrolimus-and-potential-protective-effect-from-rapamycin
#26
JOURNAL ARTICLE
Xiao Chen, Ke Hu, Hao-Zhe Shi, Yi-Jia Zhang, Liang Chen, Su-Mei He, Dong-Dong Wang
BACKGROUND: The treatment of tacrolimus-induced post-transplantation diabetes mellitus (PTDM) has become a hot topic to improve the long-term survival of organ transplant patients, however whose pathogenesis has not been fully elucidated. In pancreas, the up-regulation of NF-κB has been reported to stimulate cytokine IL-1β/TNF-α secretion, inducing pancreatic injury, meanwhile other studies have reported the inhibitory effect of rapamycin on NF-κB. PURPOSE: The aim of this study was to clarify the mechanism of tacrolimus-induced pancreatic injury and to explore the potential effect from small dose of sirolimus...
January 5, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38176912/effect-of-tacrolimus-formulation-prolonged-release-vs-immediate-release-on-its-susceptibility-to-drug-drug-interactions-with-st-john-s-wort
#27
JOURNAL ARTICLE
Katja S Gümüs, Anna Teegelbekkers, Max Sauter, Andreas D Meid, Jürgen Burhenne, Johanna Weiss, Antje Blank, Walter E Haefeli, David Czock
Tacrolimus is metabolized by cytochrome P450 3A (CYP3A) and is susceptible to interactions with the CYP3A and P-glycoprotein inducer St. John's Wort (SJW). CYP3A isozymes are predominantly expressed in the small intestine and liver. Prolonged-release tacrolimus (PR-Tac) is largely absorbed in distal intestinal segments and is less susceptible to CYP3A inhibition. The effect of induction by SJW is unknown. In this randomized, crossover trial, 18 healthy volunteers received single oral tacrolimus doses (immediate-release [IR]-Tac or PR-Tac, 5 mg each) alone and during induction by SJW...
January 4, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38159374/skin-delivery-of-synthetic-benzoyl-pterostilbenes-suppresses-atopic-dermatitis-like-inflammation-through-the-inhibition-of-keratinocyte-and-macrophage-activation
#28
JOURNAL ARTICLE
Kai-Wei Tang, Ching-Yun Hsu, Ibrahim A Aljuffali, Ahmed Alalaiwe, Wang-Ni Lai, Pei-Yu Gu, Chih-Hua Tseng, Jia-You Fang
Atopic dermatitis (AD) is one of the most common skin autoimmune diseases needing continuous anti-inflammatory management. Pterostilbene is reported to exhibit anti-inflammatory activity with higher bioavailability and stability than its parent compound, resveratrol. In this study, a series of synthetic pterostilbene analogs were designed by the hybridization of pterostilbene with chalcones or benzoyl chloride. Seventeen analogs derived from pterostilbene were synthesized with differences in the positions of hydroxyl, methoxyl, or fluoro moieties...
December 29, 2023: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38157025/apigenin-protects-melanocytes-and-improve-tyrosinase-activity-in-a-hydroquinone-induced-vitiligo-mouse-model-targeting-p38-map-kinase-signaling-histopathology-and-immunohistochemistry-analysis
#29
JOURNAL ARTICLE
Kanupriya Chauhan, Falguni Goel, Shamsher Singh
Apigenin (APG) is a plant-based flavonoid that possesses antioxidants, anti-inflammatory, and modulates P38 MAPK as well as tyrosinase. Hydroquinone (HQ), a phenolic compound was used to induce vitiligo in C57BL/6 mice. The present study was performed to check the therapeutic potential of apigenin in HQ-induced vitiligo via targeting P38 MAPK pathway. In the present study, 41 C57BL/6 mice were divided into six groups containing seven animals per group except normal group. (I) normal group, (II) HQ group, (III) to (IV) APG with (1%, 2...
December 29, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/38155084/review-of-two-immunosuppressants-tacrolimus-and-cyclosporine
#30
REVIEW
HyunJong Lee, Hoon Myoung, Soung Min Kim
Immunosuppressants are vital in organ transplantation including facial transplantation (FT) but are associated with persistent side effects. This review article was prepared to compare the two most used immunosuppressants, cyclosporine and tacrolimus, in terms of mechanism of action, efficacy, and safety and to assess recent trials to mitigate their side effects. PubMed and Google Scholar queries were conducted using combinations of the following search terms: "transplantation immunosuppressant," "cyclosporine," "tacrolimus," "calcineurin inhibitor (CNI)," "efficacy," "safety," "induction therapy," "maintenance therapy," and "conversion therapy...
December 31, 2023: Journal of the Korean Association of Oral and Maxillofacial Surgeons
https://read.qxmd.com/read/38151846/tacrolimus-pharmacotherapy-infectious-complications-and-toxicity-in-organ-transplant-recipients-an-updated-review
#31
JOURNAL ARTICLE
Zahra Tolou Ghamari, Abbas Ali Palizban
BACKGROUND: After allogeneic organ transplantation, in order to reduce the risk of rejection, tacrolimus is given. In fact, infection is reported as one of the most common side effects of tacrolimus that might be associated with graft failure. OBJECTIVE: This study aims to review the association between the occurrence of infections due to toxicity following the administration of tacrolimus in organ transplant recipients. METHODS: Scientific literature on the pharmacotherapy of tacrolimus after organ transplantation, infections, and neurotoxicity were searched using PUBMED...
December 22, 2023: Current Drug Research Reviews
https://read.qxmd.com/read/38148123/a-rare-case-of-cutaneous-lupus-erythematosus-presenting-with-periorbital-erythema-and-edema
#32
JOURNAL ARTICLE
Fatmanur Hacınecipoğlu, Bengü Çevirgen Cemil, Selda Pelin Kartal, Sehbal Arslankoz
Cutaneous lupus erythematosus (CLE) is an autoimmune skin disease that can manifest itself with a variety of skin symptoms. Periorbital erythema, a rare variant of CLE, presents challenges in terms of diagnosis and treatment. Here, we report a case of CLE presenting with periorbital erythema and edema. A 42-year-old female patient presented with complaints of erythema, edema, and scaling on the right eyelid that started four months ago. A skin biopsy was performed on the lesioned skin of the eyelid to differentiate dermatomyositis, cutaneous lupus erythematosus, sarcoidosis, lupus vulgaris, and cutaneous lymphoma...
December 26, 2023: Lupus
https://read.qxmd.com/read/38130522/topical-medications-for-atopic-dermatitis-and-effects-on-increasing-lymphoma-risks
#33
REVIEW
Brooke E Bocklud, Logan T Roberts, Dean T Roberts, Anne Schwartz, Harish Siddaiah, Shahab Ahmadzadeh, Giustino Varrassi, Sahar Shekoohi, Alan D Kaye
Atopic dermatitis is an immune-mediated skin condition that causes relapsing, pruritic skin lesions. Flares of this disease are often treated with topical corticosteroids; however, the use of these drugs can cause unwanted side effects, such as cutaneous atrophy and impaired wound healing. To minimize these common side effects, severe forms of this disease have been treated with topical calcineurin inhibitors, which previously had no known long-term side effects. Recently, there has been debate on the immunosuppressive effects of these drugs and whether chronic use could result in non-melanoma skin cancer...
November 2023: Curēus
https://read.qxmd.com/read/38115296/a-case-report-of-dermatomyositis-mimicking-myasthenia-gravis
#34
JOURNAL ARTICLE
Zhang-Si Jin, Xiao-Ran Tao, Zai-Xing Wang
RATIONALE: Patients who have myasthenia gravis or dermatomyositis show clinical signs of muscular weakening. Ocular muscle involvement is uncommon, and symmetrical proximal limb weakness is the typical presentation of dermatomyositis. However, the earliest and most noticeable sign in those with myasthenia gravis is extraocular muscular paralysis. Dermatomyositis is frequently complicated by malignancy, and the common malignancies associated with dermatomyositis vary by region and ethnicity, while thymoma is relatively rare...
December 15, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/38097123/lichen-sclerosus-associated-with-turner-syndrome-treated-with-photodynamic-therapy-a-case-report
#35
Yukun Wang, Jie Liu
Turner syndrome (TS) is a rare clinical condition associated with a completely or partially absence, or structural abnormality of an X chromosome, mainly representing as short stature and skeletal anomalies, female hypergonadotropic hypogonadism and infertility. Skin is frequently involved in TS, especially autoimmune diseases like vitiligo and lichen sclerosus (LS). Here, we present a 10-year-old Chinese girl with TS combined with both vulvar LS (VLS) and extragenital LS, who had been misdiagnosed as eczema and vitiligo for years...
December 12, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38079459/conservative-management-of-penile-and-urethral-lichen-sclerosus-a-systematic-review
#36
REVIEW
Christine Shieh, Nizar Hakam, Robert J Pearce, Meera Nagpal, Umar Ghaffar, José L Guzman, Behzad Abbasi, Nathan M Shaw, Charles P Jones, Benjamin N Breyer
PURPOSE: To evaluate the efficacy and safety profiles of currently available conservative management options for penile and urethral lichen sclerosus. MATERIALS AND METHODS: A systematic review of existing literature on lichen sclerosus was conducted utilizing the PubMed, Embase, and Web of Science databases. References were assessed for relevance to non-surgical management of male genital lichen sclerosus by title and abstract by 3 independent reviewers, then reviewed in full and in duplicate by 5 independent reviewers...
December 11, 2023: Journal of Urology
https://read.qxmd.com/read/38078687/off-label-prescription-in-paediatric-dermatology-a-retrospective-observational-study-in-a-tertiary-hospital
#37
JOURNAL ARTICLE
Carmen Couselo-Rodríguez, Ana Batalla, Sandra Martínez-Fernández, Carmela Dávila-Pousa, Diego Soto-García, Lucía Vilanova-Trillo, Ángeles Flórez
Off-label prescription in paediatric patients is common, where some studies indicate that dermatological conditions are more prone to off-label treatment. This is the first study to analyse the prevalence of off-label prescription in paediatric dermatology consultation. This retrospective observational study was performed using the medical records of paediatric patients who were evaluated in a paediatric dermatological consultation in Pontevedra University Hospital, Pontevedra, Spain. Of the 468 patients reviewed, 186 prescriptions were issued and 51...
December 11, 2023: Acta Dermato-venereologica
https://read.qxmd.com/read/38061716/a-case-of-linear-hypertrophic-lichen-planus-in-a-pediatric-patient
#38
Jin Ju Lee, Rosa Kim, Min Young Lee, Ji Yeon Byun, You Won Choi, Hae Young Choi
Lichen planus (LP) is a chronic inflammatory disease of the skin and mucosa. Of the various types, the hypertrophic type is characterized by thickened, purplish hyperkeratotic plaques and nodules. The course of hypertrophic LP tends to be more chronic than those of other types. A 12-year-old girl presented with a 2-year history of warty papules and plaques in a zosteriform configuration along one flank. Histopathology revealed hyperkeratosis and papillomatosis with wedge-shaped hypergranulosis. A lichenoid lymphocytic infiltrate with vacuolar change in the basal layer was evident...
November 2023: Annals of Dermatology
https://read.qxmd.com/read/38031645/treatment-of-immune-mediated-keratitis-immk-in-dogs-with-immunosuppressants-observed-with-spectral-domain-optical-coherence-tomography-sd-oct
#39
Hyelin Kim, Youngseok Jeong, Eunji Lee, Kangmoon Seo, Seonmi Kang
Two dogs presented with bilateral pattern-forming corneal opacity. Treatment with topical immunosuppressants was initiated after a complete ophthalmic examination. The response to treatment was assessed by analyzing serial images using slit-lamp biomicroscopy and spectral domain optical coherence tomography (SD-OCT). Both dogs responded to topical immunosuppressants; however, the lesions recurred once the treatment was abated or withdrawn. The most effective immunosuppressant in both dogs was 0.03% tacrolimus ointment...
September 2023: Journal of Veterinary Science
https://read.qxmd.com/read/38022063/treatment-of-steroid-resistant-nodular-episcleritis-with-tacrolimus-a-case-report
#40
Ali Hendi Alghamdi
A 46-year-old male, with no chronic medical illness, complained of pain, tearing, and redness for one-month duration, with no photophobia, discharge, or decrease in visual acuity. Examination revealed a small, painful, red swelling in the left sclera. Slit-lamp examination using a narrow bright slit beam revealed edema of the episcleral layer and injection of the superficial episcleral blood vessels. The rest of the anterior segment exam and fundoscopy were normal. The laboratory investigations and systemic workup were normal...
October 2023: Curēus
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