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Topical tacrolimus

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https://www.readbyqxmd.com/read/28094416/-seasonal-leukotrichia-in-a-german-shepherd-dog-a-case-report
#1
Janine Classen, Sonya V Bettenay, Ralf S Mueller
Leukotrichia can be caused by a variety of metabolic and inflammatory diseases. Canine alopecia areata is a rare multifactorial benign non-scarring alopecia. This case report describes a seasonally recurrent leukotrichia associated with alopecia areata in a German shepherd dog. Important differential diagnoses were ruled out and histopathology finally confirmed the diagnosis of alopecia areata. Topical tacrolimus and hydrocortisone aceponate were ineffective. The cause for the seasonal character in this case remained undetermined...
January 17, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28089110/recurrence-after-management-of-meatal-balanitis-xerotica-obliterans
#2
Warren Snodgrass, Juan Soto Blanquel, Nicol Corbin Bush
INTRODUCTION: We review outcomes after management of meatal balanitis xerotica obliterans (BXO). The primary outcome was recurrent meatal BXO. METHODS: A database comprising mostly hypospadias patients was queried for meatal BXO. The disease was confirmed histologically in all cases. Management included topical steroids and/or immunosuppressants, and/or surgical excision of BXO with two-stage oral mucosa graft circumferential replacement urethroplasty. RESULTS: A total of 12 patients had meatal BXO (8 boys and 4 adults)...
November 23, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28069324/differences-in-therapeutic-effects-of-topically-applied-corticosteroid-and-tacrolimus-on-atopic-dermatitis-like-symptoms-in-nc-nga-mice
#3
Atsushi Noguchi, Mitsutoshi Tominaga, Nobuaki Takahashi, Hironori Matsuda, Yayoi Kamata, Yoshie Umehara, Kyi Chan Ko, Yasushi Suga, Hideoki Ogawa, Kenji Takamori
BACKGROUND: Topical corticosteroid and calcineurin inhibitor have similar therapeutic benefits in atopic dermatitis (AD), but the differences in therapeutic mechanisms of action of these agents against AD symptoms are not fully understood. OBJECTIVE: This study was performed to examine the different effects of topical betamethasone valerate (BMV), clobetasol propionate (CBP), and tacrolimus (TAC) on itch-related behavior and dermatitis in NC/Nga mice with AD-like symptoms...
December 24, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28025633/childhood-hypopigmented-mycosis-fungoides-a-rare-diagnosis
#4
Cláudia Patraquim, Maria Miguel Gomes, Carla Garcez, Filipa Leite, Tereza Oliva, António Santos, Armando Pinto
Primary cutaneous lymphomas (PCL) are rare in pediatrics. Mycosis fungoides (MF) is the most frequent PCL diagnosed in childhood. There are various clinical variants of MF, including the hypopigmented MF (HMF). We present a 5-year-old boy with an 18-month history of progressive, generalized, nonpruritic hypopigmented lesions with central lacy erythema. He had no improvement with emollients. Skin biopsy showed typical features of HMF. He was treated with topical corticosteroids and tacrolimus and narrow-band ultraviolet B (NBUVB) phototherapy, with good response...
2016: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/28017421/steroid-sparing-effect-of-0-1-tacrolimus-eye-drop-for-treatment-of-shield-ulcer-and-corneal-epitheliopathy-in-refractory-allergic-ocular-diseases
#5
Dai Miyazaki, Atsuki Fukushima, Yuichi Ohashi, Nobuyuki Ebihara, Eiichi Uchio, Shigeki Okamoto, Jun Shoji, Etsuko Takamura, Yayoi Nakagawa, Kenichi Namba, Hiroshi Fujishima
PURPOSE: To evaluate the effects of 0.1% topical tacrolimus alone or in combination with steroids for the treatment of shield ulcers and corneal epitheliopathy in patients with refractory allergic ocular diseases. DESIGN: Open cohort study. PARTICIPANTS: Patients with refractory allergic conjunctivitis epitheliopathy, shield ulcers, or corneal plaques (N = 791). METHODS: The 791 patients were treated with topical tacrolimus alone or in combination with topical or oral steroids...
December 22, 2016: Ophthalmology
https://www.readbyqxmd.com/read/28007668/complete-remission-of-angiolymphoid-hyperplasia-with-eosinophilia-using-topical-tacrolimus
#6
Shinpei Harada, Toshifumi Nomura, Toshinari Miyauchi, Satoru Shinkuma, Yasuyuki Fujita, Ken Arita, Hiroshi Shimizu
No abstract text is available yet for this article.
December 22, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27971646/utilization-of-topical-tacrolimus-and-topical-pimecrolimus-in-europe-results-from-the-joint-european-longitudinal-lymphoma-and-skin-cancer-evaluation-joelle-study
#7
J G Kuiper, M P van Herk-Sukel, J Castellsague, A Pottegard, I Anveden Berglind, D Dedman, L Gutierrez, B Calingaert, J Hallas, A Sundstrom, A M Gallagher, J A Kaye, C Pardo, S Perez-Guttham
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://www.readbyqxmd.com/read/27941720/effectiveness-of-topical-corticosteroid-topical-calcineurin-inhibitors-and-combination-of-them-in-the-treatment-of-vitiligo
#8
P Roy, S K Saha, P C Paul, A K Reza, A K Nandi, S Sultana, S Saha, S M Akhter, S Khatun, M Habibunnahar
Vitiligo is an acquired pigmentary skin disorder which is disfiguring and difficult to treat. Cure and response rates for vitiligo are significantly lower. This study was conducted to evaluate the effectiveness of topical corticosteroid, topical calcineurin inhibitors (tacrolimus) and combination of them in the treatment of vitilligo in two tertiary care Hospital, in the Department of Dermatology and Venereology OPD (out patient department) in Mymensingh Medical College Hospital and Jahurul Islam Medical College Hospital, Bajitpur, Kishoregonj from January 2015 to December 2015...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27929217/topical-tacrolimus-for-eczema
#9
Nathan Hitzeman, Christina Kinnevey
No abstract text is available yet for this article.
October 1, 2016: American Family Physician
https://www.readbyqxmd.com/read/27917729/efficacy-of-steroidal-vs-non-steroidal-agents-in-oral-lichen-planus-a-randomised-open-label-study
#10
A R Singh, A Rai, M Aftab, S Jain, M Singh
OBJECTIVE: This study compared the therapeutic efficacy of steroidal and non-steroidal agents for treating oral lichen planus. METHODS: Forty patients with clinical and/or histologically proven oral lichen planus were randomly placed into four groups and treated with topical triamcinolone, oral dapsone, topical tacrolimus or topical retinoid for three months. Pre- and post-treatment symptoms and signs were scored for each patient. RESULTS: Patients in all treatment groups showed significant clinical improvement after three months (p 0...
January 2017: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27904832/frontal-fibrosing-alopecia-treatment-options
#11
Raymond Fertig, Antonella Tosti
Frontal fibrosing alopecia (FFA) is a rare dermatologic disease that causes scarring and hair loss and is increasing in prevalence worldwide. FFA patients typically present with hair loss in the frontal scalp region and eyebrows which may be associated with sensations of itching or burning. FFA is a clinically distinct variant of lichen planopilaris (LPP) that affects predominantly postmenopausal women, although men and premenopausal women may also be affected. Early diagnosis and prompt treatment are necessary to prevent definitive scarring and permanent hair loss...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#12
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
January 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/27829754/a-randomized-triple-blind-clinical-trial-to-compare-the-effectiveness-of-topical-triamcinolone-acetonate-0-1-clobetasol-propionate-0-05-and-tacrolimus-orabase-0-03-in-the-management-of-oral-lichen-planus
#13
Shivakumar Sivaraman, Krishnamoorthy Santham, Aruldoss Nelson, Bijaykumar Laliytha, Pandian Azhalvel, John Hearty Deepak
BACKGROUND: Oral lichen planus (OLP) is believed to result from an abnormal T-cell mediated immune response. The most useful agent in the treatment is corticosteroids. The present study will be aimed at evaluation of therapeutic efficiency of two corticosteroids triamcinolone acetonate (0.1%) and clobetasol propionate with tacrolimus orabase (0.03%), an immunomodulator in the management of OLP. AIM: To compare the effectiveness of topical triamcinolone acetonate (0...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27804089/topical-treatment-of-facial-seborrheic-dermatitis-a-systematic-review
#14
REVIEW
Aditya K Gupta, Sarah G Versteeg
BACKGROUND: Facial seborrheic dermatitis (SD), a chronic inflammatory skin condition, can impact quality of life, and relapses can be frequent. Three broad categories of agents are used to treat SD: antifungal agents, keratolytics, and corticosteroids. Topical therapies are the first line of defense in treating this condition. OBJECTIVE: Our objective was to critically review the published literature on topical treatments for facial SD. METHODS: We searched PubMed, Scopus, Clinicaltrials...
November 2, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27747960/clinical-and-microscopic-features-of-generalized-discoid-lupus-erythematosus-in-dogs-10-cases
#15
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
December 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27725194/tacrolimus-and-curcumin-co-loaded-liposphere-gel-synergistic-combination-towards-management-of-psoriasis
#16
Anjali Jain, Sindhu Doppalapudi, Abraham J Domb, Wahid Khan
Psoriasis is an autoimmune skin disorder characterized by hyper proliferation and poor differentiation of keratinocytes. It significantly affects patient's quality of life. This study reports the anti-psoriatic efficacy of tacrolimus and curcumin loaded liposphere gel formulation. Poor solubility, poor skin penetration and erratic absorption are some problems associated with the topical delivery of these drugs. To overcome these problems, lipospheres containing combination of tacrolimus and curcumin was prepared with a particle size of nearly 50nm and incorporated into a gel for topical application...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27699846/treatment-of-childhood-vitiligo-using-tacrolimus-ointment-with-narrowband-ultraviolet-b-phototherapy
#17
Surabhi Dayal, Priyadarshini Sahu, Nidhi Gupta
BACKGROUND/OBJECTIVES: A combination of narrowband ultraviolet B (NBUVB) phototherapy plus topical tacrolimus has been used in adult vitiligo but has not yet been explored in children. We therefore sought to highlight the efficacy of this synergistic combination in childhood vitiligo. The objective was to study the clinical efficacy and safety of a combination of NBUVB with topical tacrolimus ointment 0.03% in childhood vitiligo. METHOD: In this open-label study, 20 children, 4 to 14 years of age, with symmetrical vitiligo lesions were enrolled for 24 weeks...
November 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27639683/improved-topical-delivery-of-tacrolimus-a-novel-composite-hydrogel-formulation-for-the-treatment-of-psoriasis
#18
Doris Gabriel, Thibault Mugnier, Herve Courthion, Ksanthi Kranidioti, Niki Karagianni, Maria C Denis, Maria Lapteva, Yogeshvar Kalia, Michael Möller, Robert Gurny
We have developed a composite hydrogel for improved topical delivery of the poorly soluble drug Tacrolimus (TAC) to psoriasis lesions. TAC is efficiently solubilized in methoxy poly- (ethylene glycol) hexyl substituted poly-(lactic acid) (mPEGhexPLA) based nanocarriers. For convenient and patient-friendly topical administration, TAC loaded polymeric nanocarriers were incorporated in a Carbopol® based hydrogel, to yield a composite hydrogel formulation (TAC composite hydrogel). TAC composite hydrogel was designed to have superior pharmaceutical formulation properties, delivery efficiency and local bioavailability, compared to currently available paraffin-based TAC ointments...
September 14, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27633647/comparison-of-topical-tacrolimus-and-clobetasol-in-the-management-of-symptomatic-oral-lichen-planus-a-double-blinded-randomized-clinical-trial-in-sri-lanka
#19
Pilana Vithanage Kalani Shihanika Hettiarachchi, Ruvini Manjula Hettiarachchi, Ruwan Duminda Jayasinghe, Mohaideen Sitheeque
AIM: Oral lichen planus (OLP) is a common, chronic inflammatory disease of the oral mucosa. Although several studies have shown the efficacy of different treatment modalities, a definitive cure has not yet been established. The present trial compares the effectiveness of topically-applied clobetasol and tacrolimus in the symptomatic management of OLP. METHODS: A randomized, comparative, double-blind study with 68 patients (43 females, 25 males; mean age: 46.76 years) was undertaken...
September 15, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27617730/granuloma-faciale-treatment-with-tacrolimus
#20
Sergio Santos-Alarcon, Celia Sanchis-Sánchez, Francisco Ferrando-Roca, Almudena Mateu-Puchades
We present a 40-year-old woman with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, smooth red to brown nodule was seen at the left malar region. A biopsy established the diagnosis of granuloma faciale. After two-months therapy with topical tacrolimus 0,1%, nodule was resolved.
July 15, 2016: Dermatology Online Journal
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