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Topical tacrolimus

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https://www.readbyqxmd.com/read/27917729/efficacy-of-steroidal-vs-non-steroidal-agents-in-oral-lichen-planus-a-randomised-open-label-study
#1
A R Singh, A Rai, M Aftab, S Jain, M Singh
OBJECTIVE: This study compared the therapeutic efficacy of steroidal and non-steroidal agents for treating oral lichen planus. METHODS: Forty patients with clinical and/or histologically proven oral lichen planus were randomly placed into four groups and treated with topical triamcinolone, oral dapsone, topical tacrolimus or topical retinoid for three months. Pre- and post-treatment symptoms and signs were scored for each patient. RESULTS: Patients in all treatment groups showed significant clinical improvement after three months (p 0...
December 5, 2016: Journal of Laryngology and Otology
https://www.readbyqxmd.com/read/27904832/frontal-fibrosing-alopecia-treatment-options
#2
Raymond Fertig, Antonella Tosti
Frontal fibrosing alopecia (FFA) is a rare dermatologic disease that causes scarring and hair loss and is increasing in prevalence worldwide. FFA patients typically present with hair loss in the frontal scalp region and eyebrows which may be associated with sensations of itching or burning. FFA is a clinically distinct variant of lichen planopilaris (LPP) that affects predominantly postmenopausal women, although men and premenopausal women may also be affected. Early diagnosis and prompt treatment are necessary to prevent definitive scarring and permanent hair loss...
November 2016: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#3
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
November 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27829754/a-randomized-triple-blind-clinical-trial-to-compare-the-effectiveness-of-topical-triamcinolone-acetonate-0-1-clobetasol-propionate-0-05-and-tacrolimus-orabase-0-03-in-the-management-of-oral-lichen-planus
#4
Shivakumar Sivaraman, Krishnamoorthy Santham, Aruldoss Nelson, Bijaykumar Laliytha, Pandian Azhalvel, John Hearty Deepak
BACKGROUND: Oral lichen planus (OLP) is believed to result from an abnormal T-cell mediated immune response. The most useful agent in the treatment is corticosteroids. The present study will be aimed at evaluation of therapeutic efficiency of two corticosteroids triamcinolone acetonate (0.1%) and clobetasol propionate with tacrolimus orabase (0.03%), an immunomodulator in the management of OLP. AIM: To compare the effectiveness of topical triamcinolone acetonate (0...
October 2016: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/27804089/topical-treatment-of-facial-seborrheic-dermatitis-a-systematic-review
#5
REVIEW
Aditya K Gupta, Sarah G Versteeg
BACKGROUND: Facial seborrheic dermatitis (SD), a chronic inflammatory skin condition, can impact quality of life, and relapses can be frequent. Three broad categories of agents are used to treat SD: antifungal agents, keratolytics, and corticosteroids. Topical therapies are the first line of defense in treating this condition. OBJECTIVE: Our objective was to critically review the published literature on topical treatments for facial SD. METHODS: We searched PubMed, Scopus, Clinicaltrials...
November 2, 2016: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/27747960/clinical-and-microscopic-features-of-generalized-discoid-lupus-erythematosus-in-dogs-10-cases
#6
Frane Banovic, Keith E Linder, Maarja Uri, Michael A Rossi, Thierry Olivry
BACKGROUND: Generalized discoid lupus erythematosus (GDLE) is a newly recognized canine variant of chronic cutaneous lupus erythematosus (CLE) that is not well characterized. HYPOTHESIS/OBJECTIVES: We report herein the signalment, clinical signs, treatment outcome, histopathology and immunological findings of 10 dogs with GDLE. METHODS: Inclusion criteria were: (i) a >3 month history of generalized skin lesions indicating a chronic or recurrent nature; (ii) skin lesions resembling those of human GDLE; (iii) histopathology of CLE (lymphocyte-rich interface dermatitis)...
December 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27725194/tacrolimus-and-curcumin-co-loaded-liposphere-gel-synergistic-combination-towards-management-of-psoriasis
#7
Anjali Jain, Sindhu Doppalapudi, Abraham J Domb, Wahid Khan
Psoriasis is an autoimmune skin disorder characterized by hyper proliferation and poor differentiation of keratinocytes. It significantly affects patient's quality of life. This study reports the anti-psoriatic efficacy of tacrolimus and curcumin loaded liposphere gel formulation. Poor solubility, poor skin penetration and erratic absorption are some problems associated with the topical delivery of these drugs. To overcome these problems, lipospheres containing combination of tacrolimus and curcumin was prepared with a particle size of nearly 50nm and incorporated into a gel for topical application...
October 8, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27699846/treatment-of-childhood-vitiligo-using-tacrolimus-ointment-with-narrowband-ultraviolet-b-phototherapy
#8
Surabhi Dayal, Priyadarshini Sahu, Nidhi Gupta
BACKGROUND/OBJECTIVES: A combination of narrowband ultraviolet B (NBUVB) phototherapy plus topical tacrolimus has been used in adult vitiligo but has not yet been explored in children. We therefore sought to highlight the efficacy of this synergistic combination in childhood vitiligo. The objective was to study the clinical efficacy and safety of a combination of NBUVB with topical tacrolimus ointment 0.03% in childhood vitiligo. METHOD: In this open-label study, 20 children, 4 to 14 years of age, with symmetrical vitiligo lesions were enrolled for 24 weeks...
October 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27639683/improved-topical-delivery-of-tacrolimus-a-novel-composite-hydrogel-formulation-for-the-treatment-of-psoriasis
#9
Doris Gabriel, Thibault Mugnier, Herve Courthion, Ksanthi Kranidioti, Niki Karagianni, Maria C Denis, Maria Lapteva, Yogeshvar Kalia, Michael Möller, Robert Gurny
We have developed a composite hydrogel for improved topical delivery of the poorly soluble drug Tacrolimus (TAC) to psoriasis lesions. TAC is efficiently solubilized in methoxy poly- (ethylene glycol) hexyl substituted poly-(lactic acid) (mPEGhexPLA) based nanocarriers. For convenient and patient-friendly topical administration, TAC loaded polymeric nanocarriers were incorporated in a Carbopol® based hydrogel, to yield a composite hydrogel formulation (TAC composite hydrogel). TAC composite hydrogel was designed to have superior pharmaceutical formulation properties, delivery efficiency and local bioavailability, compared to currently available paraffin-based TAC ointments...
September 14, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27633647/comparison-of-topical-tacrolimus-and-clobetasol-in-the-management-of-symptomatic-oral-lichen-planus-a-double-blinded-randomized-clinical-trial-in-sri-lanka
#10
Pilana Vithanage Kalani Shihanika Hettiarachchi, Ruvini Manjula Hettiarachchi, Ruwan Duminda Jayasinghe, Mohaideen Sitheeque
AIM: Oral lichen planus (OLP) is a common, chronic inflammatory disease of the oral mucosa. Although several studies have shown the efficacy of different treatment modalities, a definitive cure has not yet been established. The present trial compares the effectiveness of topically-applied clobetasol and tacrolimus in the symptomatic management of OLP. METHODS: A randomized, comparative, double-blind study with 68 patients (43 females, 25 males; mean age: 46.76 years) was undertaken...
September 15, 2016: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/27617730/granuloma-faciale-treatment-with-tacrolimus
#11
Sergio Santos-Alarcon, Celia Sanchis-Sánchez, Francisco Ferrando-Roca, Almudena Mateu-Puchades
We present a 40-year-old woman with a one-year history of a solitary and asymptomatic facial lesion. On physical examination a slightly infiltrated, smooth red to brown nodule was seen at the left malar region. A biopsy established the diagnosis of granuloma faciale. After two-months therapy with topical tacrolimus 0,1%, nodule was resolved.
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27590106/an-open-label-phase-ii-randomized-trial-of-topical-dexamethasone-and-tacrolimus-solutions-for-the-treatment-of-oral-chronic-graft-versus-host-disease
#12
Nathaniel Treister, Shuli Li, Haesook Kim, Mark Lerman, Ahmed Sultan, Edwin P Alyea, Philippe Armand, Corey Cutler, Vincent Ho, John Koreth, Joseph H Antin, Robert Soiffer
The objective of this study was to evaluate the safety and efficacy of single-agent dexamethasone or tacrolimus topical solution as first-line treatment for symptomatic oral chronic graft-versus-host disease (cGVHD). This was a prospective, single-center, open-label, randomized phase II trial of patients with symptomatic oral cGVHD without prior topical therapy. Subjects were randomly assigned 1:1 to either topical dexamethasone (.5 mg/mL) or tacrolimus (.5 mg/mL) solution and instructed to rinse with 5 mL for 5 minutes, 4 times a day, for 4 weeks...
November 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27588441/inappropriate-amounts-of-topical-tacrolimus-applied-on-korean-patients-with-eczema
#13
Hyunju Jin, Jeong-Min Kim, Gun-Wook Kim, Hoon-Soo Kim, Hyun-Chang Ko, Moon-Bum Kim, Byung-Soo Kim
BACKGROUND: The limited efficacy of topical tacrolimus may result from insufficient frequency of application or amount applied in eczema patients. OBJECTIVE: To investigate the frequency of application and amount of use of topical tacrolimus in patients with various types of eczema. METHODS: The frequency of application and the applied amount of topical tacrolimus were assessed over two weeks. RESULTS: A total of 200 eczema patients completed this study...
September 15, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/27578082/uremic-itch-management
#14
Thomas Mettang
Uremic itch is a frequent and sometimes very tormenting symptom in patients with advanced or end-stage renal failure, with a strong negative impact on the quality of life. According to a representative study, the point prevalence of chronic itch is 25% in hemodialysis patients but may reach more than 50% in single cohorts depending on the country and dialysis efficacy. Not much is known regarding the pathogenesis of uremic itch. Besides parathyroid hormone, histamine, tryptase, and alteration of the calcium-phosphate metabolism have been suspected...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27578080/neurologic-itch-management
#15
Ekin Şavk
Neurologic itch is defined as pruritus resulting from any dysfunction of the nervous system. Itch arising due to a neuroanatomic pathology is seen to be neuropathic. Causes of neuropathic itch range from localized entrapment of a peripheral nerve to generalized degeneration of small nerve fibers. Antipruritic medications commonly used for other types of itch such as antihistamines and corticosteroids lack efficacy in neuropathic itch. Currently there are no therapeutic options that offer relief in all types of neuropathic pruritus, and treatment strategies vary according to etiology...
2016: Current Problems in Dermatology
https://www.readbyqxmd.com/read/27572623/topical-tacrolimus-causing-gingival-hyperplasia-a-case-report
#16
Dr Minu Jose Chiramel, Dr Sudhir Singh, Dr Somesh Gupta
No abstract text is available yet for this article.
August 29, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27570137/proliferative-and-necrotizing-otitis-externa-in-a-kitten-successful-treatment-with-intralesional-and-topical-corticosteroid-therapy
#17
Yutaka Momota, Junya Yasuda, Mitsutaka Ikezawa, Jun Sasaki, Masaaki Katayama, Kenji Tani, Masahiro Miyabe, Eri Onozawa, Daigo Azakami, Katsumi Ishioka, Toshinori Sako
Proliferative and necrotising otitis externa (PNOE) is a very rare disease affecting the ear canals and concave pinnae of kittens. This report describes a 5-month-old cat with PNOE. Histopathological examination confirmed the diagnosis. Treatment was initiated with local injection of methylprednisolone acetate into the lesions. The cat was subsequently treated with clobetasol propionate cream, a potent topical glucocorticoid ointment. The cat showed marked improvement. While topical treatment with tacrolimus, an immunosuppressive agent, is reported to be an effective therapy, to the best of our knowledge, this is the first report to treat PNOE with local corticosteroid therapy...
August 28, 2016: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/27552666/improvement-of-erythema-dyschromicum-perstans-using-a-combination-of-the-1-550-nm-erbium-doped-fractionated-laser-and-topical-tacrolimus-ointment
#18
Jon A Wolfshohl, Elizabeth R C Geddes, Ashlyn B Stout, Paul M Friedman
BACKGROUND AND OBJECTIVE: Erythema dyschromicum perstans (EDP) is a cosmetically distressing, acquired pigmentary disorder of unknown etiology for which few successful therapies exist. Herein, we present the successful use of non-ablative fractional photothermolysis in combination with topical tacrolimus ointment. STUDY DESIGN/PATIENTS AND METHODS: A 35-year-old female with biopsy-confirmed EDP underwent a series of fractionated non-ablative treatment sessions utilizing the 1,550 nm erbium-doped fiber laser in combination with topical tacrolimus ointment over a period of 5 months...
August 23, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27552312/comparison-of-the-efficacy-of-308-nm-excimer-lamp-monotherapy-with-topical-tacrolimus-or-clobetasol-17-propionate-combination-therapies-in-localized-vitiligo
#19
Funda Bapur Erduran, Esra Adışen
BACKGROUND: In recent years, excimer light treatments have come to the fore in localized vitiligo because of their high efficacy and safety. OBJECTIVE: We aimed to evaluate the efficacy of 308-nm excimer lamp as a monotherapy and its combination with tacrolimus 0.1% or clobetasol 17-propionate 0.05% ointment in localized vitiligo. METHODS: We performed a retrospective study including a total of 82 patients who were treated with excimer lamp monotherapy (EL group) (n = 30), excimer lamp + topical tacrolimus (EL + T group) (n = 29), or excimer lamp + topical clobetasol 17-propionate (EL + CS group) (n = 23)...
September 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/27518840/allergic-manifestations-of-contact-lens-wearing
#20
Abraham Solomon
PURPOSE OF REVIEW: Contact lens-induced papillary conjunctivitis (CLPC) is a common ocular allergic disease in contact lens wearers. In its more severe form, it can cause giant papillary conjunctivitis, resulting in contact lens intolerance and the need to discontinue the use of contact lenses. This review presents the pathogenesis, clinical manifestations and management guidelines of this common disorder. RECENT FINDINGS: Different types of contact lenses are associated with differences in the severity of CLPC...
October 2016: Current Opinion in Allergy and Clinical Immunology
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