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https://www.readbyqxmd.com/read/28102963/diagnostic-value-of-endobronchial-ultrasound-elastography-for-the-differentiation-of-benign-and-malignant-intrathoracic-lymph-nodes
#1
Potjanee Korrungruang, Viboon Boonsarngsuk
BACKGROUND AND OBJECTIVE: Endobronchial ultrasound (EBUS) findings can be used for benign/malignant differentiation of lymph nodes (LNs). Recently, EBUS elastography has been introduced as a complementary modality in the evaluation of intrathoracic lymphadenopathy. We evaluated the ability of EBUS elastography to differentiate between benign and malignant LNs. METHODS: A prospective study was conducted on patients sent for evaluation of intrathoracic lymphadenopathy...
January 19, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28102328/qualitative-and-quantitative-analysis-with-a-novel-shear-wave-speed-imaging-for-differential-diagnosis-of-breast-lesions
#2
Yu-Ping Yang, Xiao-Hong Xu, Le-Hang Guo, Ya-Ping He, Dan Wang, Bo-Ji Liu, Chong-Ke Zhao, Bao-Ding Chen, Hui-Xiong Xu
To evaluate the diagnostic performance of a new two-dimensional shear wave speed (SWS) imaging (i.e. Toshiba shear wave elastography, T-SWE) in differential diagnosis of breast lesions. 225 pathologically confirmed breast lesions in 218 patients were subject to conventional ultrasound and T-SWE examinations. The mean, standard deviation and ratio of SWS values (m/s) and elastic modulus (KPa) on T-SWE were computed. Besides, the 2D elastic images were classified into four color patterns. The area under the receiver operating characteristic (AUROC) curve analysis was performed to evaluate the diagnostic performance of T-SWE in differentiation of breast lesions...
January 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28101423/assessing-the-effects-of-riboflavin-uv-a-crosslinking-on-porcine-corneal-mechanical-anisotropy-with-optical-coherence-elastography
#3
Manmohan Singh, Jiasong Li, Zhaolong Han, Raksha Raghunathan, Achuth Nair, Chen Wu, Chih-Hao Liu, Salavat Aglyamov, Michael D Twa, Kirill V Larin
In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young's modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young's modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28101352/shear-wave-elastography-and-contrast-enhanced-ultrasonography-in-the-diagnosis-of-thyroid-malignant-nodules
#4
Mei Chen, Ke-Qin Zhang, You-Feng Xu, Sheng-Min Zhang, Yong Cao, Wei-Qun Sun
The aim of the present study was to evaluate the value of shear wave elastography (SWE) and contrast-enhanced ultrasonography (CEUS) in the diagnosis of thyroid malignant nodules. A total of 253 patients with 319 thyroid nodules were subjected to two-dimensional ultrasound (2DUS) and CEUS examinations prior to thyroidectomy between March, 2014 and December, 2015. Young's modulus value for each nodule on 2DUS and CEUS images were recorded. The sensitivity, specificity and accuracy of 2DUS, SWE and CEUS in the diagnosis of thyroid malignant nodules were assessed...
December 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28100996/intrapancreatic-accessory-spleen-a-diagnosis-not-to-forget
#5
Susana Marques, Miguel Bispo, Lariño Noia
A 69-year-old male patient was incidentally diagnosed with a 5-mm lesion in the pancreatic tail by endoscopic ultrasound (EUS). After contrast-enhanced EUS and EUS-elastography, all imaging features were highly suggestive of a benign pancreatic solid lesion such as an intrapancreatic accessory spleen (IPAS) or a benign neuroendocrine tumor. Interposition of the splenic artery precluded EUS-guided fine-needle aspiration (FNA). When an asymptomatic pancreatic mass is detected, IPAS diagnosis should be considered, and, if EUS-FNA is infeasible, contrast-enhanced EUS and EUS-elastography are useful tools to differentiate a pancreatic benign lesion as IPAS from a malignancy, with avoidance of unnecessary surgery...
September 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28100410/comp-serum-levels-a-new-non-invasive-biomarker-of-liver-fibrosis-in-patients-with-chronic-viral-hepatitis
#6
Kalliopi Zachou, Stella Gabeta, Zakera Shums, Nikolaos K Gatselis, George K Koukoulis, Gary L Norman, George N Dalekos
BACKGROUND & AIMS: Recently we have shown that cartilage oligomeric matrix protein (COMP), a fibrillar collagen assembly regulator, is strongly associated with cirrhosis and hepatocellular carcinoma progression. Therefore, we assessed whether serum COMP levels can be used as a non-invasive fibrosis marker in patients with chronic viral hepatitis (CVH) and compared this marker with standard methods for disease stage assessment [histology, transient elastography (TE), APRI, FIB-4]. METHODS: Sera from 116 CVH patients, 66 HBV [24 female; median age 53(22-76)] and 50 HCV [21 female; median age 48...
January 15, 2017: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/28099260/differentiation-of-pancreatic-masses-via-endoscopic-ultrasound-strain-ratio-elastography-using-adjacent-pancreatic-tissue-as-the-reference
#7
Nadan Rustemović, Mirjana Kalauz, Katja Grubelić Ravić, Hrvoje Iveković, Branko Bilić, Zvonimir Ostojić, Dalibor Opačić, Iva Ledinsky, Matea Majerović, Ana Višnjić
OBJECTIVES: The aims of this study were to evaluate diagnostic value of endoscopic ultrasound strain ratio elastography in patients with focal pancreatic masses and to determine the cutoff value between the pancreatic malignancies and inflammatory pancreatic masses using reference areas different than those used by other investigators. METHODS: In a prospective single-center study, strain ratio was measured in patients with pancreatic masses. After the diagnosis was established, statistical analysis was used to compare the group with pancreatic malignancies to the one with inflammatory masses...
January 18, 2017: Pancreas
https://www.readbyqxmd.com/read/28097687/requirements-for-accurate-estimation-of-anisotropic-material-parameters-by-magnetic-resonance-elastography-a-computational-study
#8
D J Tweten, R J Okamoto, P V Bayly
PURPOSE: To establish the essential requirements for characterization of a transversely isotropic material by magnetic resonance elastography (MRE). THEORY AND METHODS: Three methods for characterizing nearly incompressible, transversely isotropic (ITI) materials were used to analyze data from closed-form expressions for traveling waves, finite-element (FE) simulations of waves in homogeneous ITI material, and FE simulations of waves in heterogeneous material. Key properties are the complex shear modulus μ2 , shear anisotropy ϕ=μ1/μ2-1, and tensile anisotropy ζ=E1/E2-1...
January 17, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28097068/hepatic-fibrosis-and-factors-associated-with-liver-stiffness-in-hiv-mono-infected-individuals
#9
Mihály Sulyok, Tamás Ferenci, Mihály Makara, Gábor Horváth, János Szlávik, Zsófia Rupnik, Luca Kormos, Zsuzsanna Gerlei, Zita Sulyok, István Vályi-Nagy
BACKGROUND: Liver disease has become an important cause of morbidity and mortality even in those HIV-infected individuals who are devoid of hepatitis virus co-infection. The aim of this study was to evaluate the degree of hepatic fibrosis and the role of associated factors using liver stiffness measurement in HIV mono-infected patients without significant alcohol intake. METHODS: We performed a cross-sectional study of 101 HIV mono-infected patients recruited prospectively from March 1, 2014 to October 30, 2014 at the Center for HIV, St István and St László Hospital, Budapest, Hungary...
2017: PeerJ
https://www.readbyqxmd.com/read/28095866/improvement-of-displacement-estimation-of-breast-tissue-in-ultrasound-elastography-using-the-monogenic-signal
#10
Taher Slimi, Ines Marzouk Moussa, Tarek Kraiem, Halima Mahjoubi
BACKGROUND: In breast ultrasound elastography, tissues displacements estimation is obtained through a technique that follows the evolution of tissues under stress. However, during the acquisition of B-mode images, tissue displacements are often contaminated with multiplicative noise caused by changes in the speckle pattern in the tissue. Thus, the application of monogenic signal technique on the B-mode image in order to estimate displacement tissue, result in a presence of amplified noise in the deformation tissue image, which severely obscures the useful information...
January 17, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28094066/implementation-of-elastography-score-and-strain-ratio-in-combination-with-b-mode-ultrasound-avoids-unnecessary-biopsies-of-breast-lesions
#11
Kristina Bojanic, Natasa Katavic, Martina Smolic, Marija Peric, Kristina Kralik, Miroslav Sikora, Kristina Vidačić, Mirta Pacovski, Damir Stimac, Gordana Ivanac
The aim of this study was to evaluate whether the combination of B-mode ultrasound, elastography score (ES) and strain ratio (SR) improves diagnostic performance with respect to breast lesions. One hundred thirty lesions were prospectively evaluated by B-mode ultrasound and strain elastography, followed by fine-needle aspiration cytology/biopsy in 117 woman who were scheduled for regular breast BUS. The median ES (4.5 vs. 2.9, p < 0.001) and SR (4.9 vs. 2.3, p < 0.001) were significantly higher for malignant than for benign lesions...
January 13, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28093695/serum-zinc-deficiency-and-its-relation-to-liver-fibrosis-in-chronic-hcv-a-real-life-egyptian-study
#12
Dalia A Omran, Samar Kamal Darweesh, Hanan Fouad, Mohamed Mahmoud, Sameh Saif, Azza Fared, Mohamed Hassany, Lamiaa Mobarak, Mahmoud A El-Tahawy, Ayman Yosry
Zinc is essential for the activation of approximately 300 metallo-enzymes. Serum and hepatic zinc is decreased in chronic liver disease patients, and zinc depletion has been suggested to accelerate liver fibrosis. The study was designed to assess Zinc status in chronic HCV Egyptian patients and its relationship to fibrosis stage diagnosed by FibroScan. This was a cross-sectional study on 297 Egyptian patients with naïve chronic HCV. All patients underwent laboratory tests (including assessment of serum Zinc) and liver stiffness measurement (LSM) by Transient Elastography (FibroScan(®))...
January 16, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28092638/mr-elastography-to-measure-the-effects-of-cancer-and-pathology-fixation-on-prostate-biomechanics-and-comparison-with-t-1-t-2-and-adc
#13
Deirdre M McGrath, Jenny Lee, Warren D Foltz, Navid Samavati, Theo van der Kwast, Michael A S Jewett, Peter Chung, Cynthia Ménard, Kristy K Brock
MRI is under evaluation for image-guided intervention for prostate cancer. The sensitivity and specificity of MRI parameters is determined via correlation with the gold-standard of histopathology. Whole-mount histopathology of prostatectomy specimens can be digitally registered to in vivo imaging for correlation. When biomechanical-based deformable registration is employed to account for deformation during histopathology processing, the ex vivo biomechanical properties are required. However, these properties are altered by pathology fixation, and vary with disease...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28092636/an-analysis-of-intrinsic-variations-of-low-frequency-shear-wave-speed-in-a-stochastic-tissue-model-the-first-application-for-staging-liver-fibrosis
#14
Yu Wang, Min Wang, Jingfeng Jiang
Shear wave elastography is increasingly being used to non-invasively stage liver fibrosis by measuring shear wave speed (SWS). This study quantitatively investigates intrinsic variations among SWS measurements obtained from heterogeneous media such as fibrotic livers. More specifically, it aims to demonstrate that intrinsic variations in SWS measurements, in general, follow a non-Gaussian distribution and are related to the heterogeneous nature of the medium being measured. Using the principle of maximum entropy (ME), our primary objective is to derive a probability density function (PDF) of the SWS distribution in conjunction with a lossless stochastic tissue model...
February 7, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28092532/improved-shear-wave-group-velocity-estimation-method-based-on-spatiotemporal-peak-and-thresholding-motion-search
#15
Carolina Amador Carrascal, Shigao Chen, Armando Manduca, James F Greenleaf, Matthew Urban
Quantitative ultrasound elastography is increasingly being used in the assessment of chronic liver disease. Many studies have reported ranges of liver shear wave velocities values for healthy individuals and patients with different stages of liver fibrosis. Nonetheless, ongoing efforts exist to stabilize quantitative ultrasound elastography measurements by assessing factors that influence tissue shear wave velocity values, such as food intake, body mass index (BMI), ultrasound scanners, scanning protocols, ultrasound image quality, etc...
January 11, 2017: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control
https://www.readbyqxmd.com/read/28091280/rotation-elastogram-estimation-using-synthetic-transmit-aperture-technique
#16
Lokesh B, Bhaskara Rao Chintada, Arun Kumar Thittai
It is well-documented in literature that benign breast lesions, such as fibroadenomas, are loosely bonded to their surrounding tissue and tend to slip under a small quasi-static compression, whereas malignant lesions being firmly bonded to their surrounding tissue do not slip. Recent developments in quasi-static ultrasound elastography have shown that an image of the axial-shear strain distribution can provide information about the bonding condition at the lesion-surrounding tissue boundary. Further studies analyzing the axial-shear strain elastograms revealed that nonzero axial-shear strain values appear inside the lesion, referred to as fill-in, only when a lesion is loosely bonded and asymmetrically oriented to the axis of compression...
January 1, 2017: Ultrasonic Imaging
https://www.readbyqxmd.com/read/28090117/generation-of-shear-waves-by-laser-in-soft-media-in-the-ablative-and-thermoelastic-regimes
#17
Pol Grasland-Mongrain, Yuankang Lu, Frederic Lesage, Stefan Catheline, Guy Cloutier
This article describes the generation of elastic shear waves in a soft medium using a laser beam. Our experiments show two different regimes depending on laser energy. Physical modeling of the underlying phenomena reveals a thermoelastic regime caused by a local dilatation resulting from temperature increase, and an ablative regime caused by a partial vaporization of the medium by the laser. Computed theoretical displacements are close to experimental measurements. A numerical study based on the physical modeling gives propagation patterns comparable to those generated experimentally...
November 28, 2016: Applied Physics Letters
https://www.readbyqxmd.com/read/28089429/diagnosis-and-quantification-of-fibrosis-steatosis-and-hepatic-siderosis-through-multiparametric-magnetic-resonance-imaging
#18
M Stoopen-Rometti, E R Encinas-Escobar, C R Ramirez-Carmona, E Wolpert-Barraza, E Kimura-Hayama, L A Sosa-Lozano, R Favila, Y Kimura-Fujikami, J A Saavedra-Abril, A Loaeza-Del Castillo
BACKGROUND: The presence of liver fibrosis is the common denominator in numerous chronic liver diseases that can progress to fibrosis and hepatocellular carcinoma. Most important, with respect to frequency, are viral hepatitis and non-alcoholic fatty liver disease, the prevalence of which is increasing in epidemic proportions. Liver biopsy, albeit imperfect, continues to be the criterion standard, but in many clinical situations tends to be replaced with noninvasive imaging methods. OBJECTIVES: The aim of the present article was to describe our imaging department experience with magnetic resonance elastography and to analyze and discuss recently published results in gastroenterology, hepatology, and radiology from other authors in the literature, complemented with a PubMed search covering the last 10 years...
January 12, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28088581/a-stepwise-algorithm-using-a-at-a-glance-first-line-test-for-the-non-invasive-diagnosis-of-advanced-liver-fibrosis-and-cirrhosis
#19
Jérôme Boursier, Victor de Ledinghen, Vincent Leroy, Rodolphe Anty, Sven Francque, Dominique Salmon, Adrien Lannes, Sandrine Bertrais, Frederic Oberti, Isabelle Fouchard-Hubert, Paul Calès
BACKGROUND & AIMS: Chronic liver diseases (CLD) are highly frequent and thus mainly managed by non-hepatologists. Because they lack access to the best non-invasive tests of liver fibrosis, these physicians cannot accurately determine the disease severity and the need for referral to a hepatologist. We aimed to implement an algorithm, comprising a new first-line test usable by all physicians, for the detection of advanced liver fibrosis in all CLD patients. METHODS: Diagnostic study: 3,754 CLD patients with liver biopsy were 2:1 randomized into derivation and validation sets...
January 11, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28087063/spatial-dependent-mechanical-properties-of-the-heel-pad-by-shear-wave-elastography
#20
Che-Yu Lin, Pei-Yu Chen, Yio-Wha Shau, Hao-Chih Tai, Chung-Li Wang
The heel pad plays an important role in gait, and its biomechanical behavior and functionality are determined by its specialized architecture and mechanical properties. The purpose of this study was to apply supersonic shear wave elastography, an ultrasound-based noninvasive modality that can quantitatively estimate the shear stiffness of the tissue, to investigate the spatial-dependent mechanical properties of the heel pad. Measurements were conducted in 40 heel pads of 20 normal participants aged between 20 and 30 years by shear wave elastography...
January 6, 2017: Journal of Biomechanics
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