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https://www.readbyqxmd.com/read/28811064/evaluation-of-non-alcoholic-fatty-liver-disease-using-acoustic-radiation-force-impulse-imaging-elastography-in-rat-models
#1
Yanrong Guo, Changfeng Dong, Haoming Lin, Xinyu Zhang, Huiying Wen, Yuanyuan Shen, Tianfu Wang, Siping Chen, Yingxia Liu, Xin Chen
The aim of this study is to evaluate the utility of acoustic radiation force impulse (ARFI) elastography for assessing hepatic fibrosis stage and non-alcoholic fatty liver disease (NAFLD) severity, as well as the relationship among hepatic histologic changes using shear wave velocity (SWV). Animal models with various degrees of NAFLD were established in 110 rats. The right liver lobe was processed and embedded in a fabricated gelatin solution (porcine skin). Liver mechanics were measured using SWV induced by acoustic radiation force...
August 12, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28807448/assessing-hepatic-fibrosis-using-2-d-shear-wave-elastography-in-patients-with-liver-tumors-a-prospective-single-center-study
#2
Zhongxi Huang, Wei Zheng, Yao-Jun Zhang, Li Xu, Jin-Bin Chen, Jian-Cong Chen, Min-Shan Chen, Zhongguo Zhou
The purpose of this study was to investigate the diagnostic performance of 2-D shear wave elastography (2-D-SWE) in evaluations of liver stiffness in patients with liver tumors before resection. A total of 121 consecutive patients with hepatocellular carcinoma (HCC) (n = 93), intra-hepatic cholangiocarcinoma (n = 6), mixed hepatocellular carcinoma and intra-hepatic cholangiocarcinoma (n = 6), liver metastases (n = 10) and benign tumors (n = 6) were prospectively enrolled in this study from June 2015 to March 2016...
August 11, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28804946/coefficient-of-variance-as-quality-criterion-for-evaluation-of-advanced-hepatic-fibrosis-using-2d-shear-wave-elastography
#3
Sanghyeok Lim, Seung Hyun Kim, Yongsoo Kim, Young Seo Cho, Tae Yeob Kim, Woo Kyoung Jeong, Joo Hyun Sohn
OBJECTIVES: To compare the diagnostic performance for advanced hepatic fibrosis measured by 2D shear-wave elastography (SWE), using either the coefficient of variance (CV) or the interquartile range divided by the median value (IQR/M) as quality criteria. METHODS: In this retrospective study, from January 2011 to December 2013, 96 patients, who underwent both liver stiffness measurement by 2D SWE and liver biopsy for hepatic fibrosis grading, were enrolled. The diagnostic performances of the CV and the IQR/M were analyzed using receiver operating characteristic curves with areas under the curves (AUCs) and were compared by Fisher's Z test, based on matching the cutoff points in an interactive dot diagram...
August 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28801939/assessment-of-advanced-hepatic-mr-elastography-methods-for-susceptibility-artifact-suppression-in-clinical-patients
#4
Jin Wang, Kevin J Glaser, Tianhui Zhang, Qungang Shan, Bingjun He, Jun Chen, Meng Yin, Bogdan Dzyubak, Jennifer L Kugel, Scott A Kruse, Roger C Grimm, Sudhakar K Venkatesh, Richard L Ehman
PURPOSE: To assess the success rate, image quality, and the ability to stage liver fibrosis of a standard 2D gradient-recalled echo (GRE) and four different spin-echo (SE) magnetic resonance elastography (MRE) sequences in patients with different liver iron concentrations. MATERIALS AND METHODS: A total of 332 patients who underwent 3T MRE examinations that included liver fat and iron quantification were enrolled, including 136 patients with all five MRE techniques...
August 11, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28800087/imaging-features-of-non-alcoholic-fatty-liver-disease-in-children-and-adolescents
#5
REVIEW
Michele Di Martino, Kameliya Koryukova, Mario Bezzi, Carlo Catalano
Non-invasive diagnosis and quantification of liver steatosis is important to overcome limits of liver biopsy, in order to follow up patients during their therapy and to establish a reference standard that can be used in clinical trials and longitudinal studies. Imaging offers several methods in this setting: ultrasound, which is the cheapest technique and easy to perform; magnetic resonance spectroscopy (MRS), which reflects the real content of triglycerides in a specific volume; and proton density fat fraction (PDFF) magnetic resonance, which is a simple method that reflects the distribution of the fat in the whole liver...
August 11, 2017: Children
https://www.readbyqxmd.com/read/28798325/virtual-touch-tissue-imaging-and-quantification-value-in-malignancy-prediction-for-complex-cystic-and-solid-breast-lesions
#6
Ying Zhang, Chong-Ke Zhao, Xiao-Long Li, Ya-Ping He, Wei-Wei Ren, Cai-Ping Zou, Yue-Wu Du, Hui-Xiong Xu
This study was aimed to evaluatethe usefulness of conventional ultrasound (US) and US elastography, including the latest virtual touch tissue imaging and quantification (VTIQ), in malignancy prediction for complex cystic and solid breast lesions. Eighty-nine complex cystic and solid breast lesions were subject to conventional US and US elastography, including strain elastography (SE), virtual touch tissue imaging (VTI) and VTIQ. Among the 89 lesions, thirty-four (38.2%) lesions were malignant and 55 (61.8%) lesions were benign...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796546/shear-wave-elastography-for-detection-of-prostate-cancer-a-systematic-review-and-diagnostic-meta-analysis
#7
Sungmin Woo, Chong Hyun Suh, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim
OBJECTIVE: The objective of this study is to review the diagnostic performance of shear-wave elastography (SWE) in the detection of prostate cancer (PCa). MATERIALS AND METHODS: The MEDLINE, EMBASE, and Cochrane library databases were searched up to December 23, 2016. We included diagnostic accuracy studies that used SWE for PCa detection with prostatectomy or biopsy used as the reference standard. The methodologic quality of the studies was evaluated by two independent reviewers using the revised Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) tool...
August 10, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28791501/skeletal-muscle-mass-to-visceral-fat-area-ratio-is-an-important-determinant-affecting-hepatic-conditions-of-non-alcoholic-fatty-liver-disease
#8
Takashi Shida, Kentaro Akiyama, Sechang Oh, Akemi Sawai, Tomonori Isobe, Yoshikazu Okamoto, Kazunori Ishige, Yuji Mizokami, Kenji Yamagata, Kojiro Onizawa, Hironori Tanaka, Hiroko Iijima, Junichi Shoda
BACKGROUND: Not only obesity but also sarcopenia is associated with NAFLD. The influence of altered body composition on the pathophysiology of NAFLD has not been fully elucidated. The aim of this study is to determine whether skeletal muscle mass to visceral fat area ratio (SV ratio) affects NAFLD pathophysiology. METHODS: A total of 472 subjects were enrolled. The association between SV ratio and NAFLD pathophysiological factors was assessed in a cross-sectional nature by stratification analysis...
August 8, 2017: Journal of Gastroenterology
https://www.readbyqxmd.com/read/28790832/combination-of-sofosbuvir-and-daclatasvir-in-the-treatment-of-genotype-3-chronic-hepatitis-c-virus-infection-in-patients-on-maintenance-hemodialysis
#9
Jan Sperl, Sona Frankova, Miluse Kreidlova, Dusan Merta, Monika Tothova, Julius Spicak
Chronic hepatitis C virus infection (HCV) has a negative impact on the long-term survival of recipients of kidney transplants. HCV should be treated in hemodialyzed patients before their enlistment for kidney transplantation in order to avoid the reactivation of virus after transplantation. Direct-acting antivirals represent the current standard of care in hemodialyzed patients with HCV genotypes 1 and 4; in patients with genotypes 2 or 3, the optimal regimen is yet to be established. Sofosbuvir (SOF) and daclatasvir (DCV) represent an antiviral pangenotypic regimen with favorable pharmacokinetics in hemodialyzed patients...
2017: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/28790227/evaluation-of-acoustic-radiation-force-impulse-arfi-for-fibrosis-staging-in-chronic-liver-diseases
#10
Rino Alvani Gani, Irsan Hasan, Andri Sanityoso, Cosmas Rinaldi A Lesmana, Juferdy Kurniawan, Chyntia Olivia Maurine Jasirwan, Kemal Fariz Kalista, Lutfie Lutfie
BACKGROUND: acoustic radiation force impulse (ARFI) is a new proposed noninvasive method for liver fibrosis staging. Integrated with B-mode ultrasonography, ARFI can be used to assess liver tissue condition. However its diagnostic accuracy is still being continuously evaluated. Also, there is lack of data regarding the utilization of ARFI in our population. This study aimed to evaluate the diagnostic value of ARFI as an alternative noninvasive modality for fibrosis staging in chronic hepatitis B and hepatitis C patients in our population...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28790222/prevalence-and-profile-of-fibrosis-in-diabetic-patients-with-non-alcoholic-fatty-liver-disease-and-the-associated-factors
#11
Ignatius Bima Prasetya, Irsan Hasan, Wismandari Wisnu, Cleopas Martin Rumende
BACKGROUND: the risk of Non-Alcoholic Fatty Liver Disease (NAFLD) is increasing in patients with type-2 diabetes. Prevalence and factors related to the increased risk of NAFLD in diabetic patients in Indonesia has never been studied before. Data regarding the profile of fibrosis in the population has also been unknown. This study aimed to identify the difference on the profile of diabetic patients with and without NAFLD as well as the degree of fibrosis. METHODS: the study was conducted using a cross-sectional method in type-2 diabetic patients who were treated at the outpatient clinic of endocrinology and metabolic division in Cipto Mangunkusumo Hospital...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28789641/effect-of-renal-perfusion-and-structural-heterogeneity-on-shear-wave-elastography-of-the-kidney-an-in-vivo-and-ex-vivo-study
#12
Xiaona Liu, Na Li, Tao Xu, Fang Sun, Rui Li, Qimin Gao, Lianxiang Chen, Chaoyang Wen
BACKGROUND: To evaluate the effect of perfusion status on elasticity measurements of different compartments in the kidney using shear wave elastography (SWE) both in vivo and ex vivo. METHODS: Thirty-two rabbit kidneys were used to observe the elasticity variation caused by renal artery stenosis and vein ligation in vivo, and six beagle kidneys were studied ex vivo to explore the effect of renal perfusion on elasticity. Supersonic SWE was applied to quantify the elasticity values of different renal compartments (cortex, medulla and sinus)...
August 8, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28789631/efficacy-of-glutathione-for-the-treatment-of-nonalcoholic-fatty-liver-disease-an-open-label-single-arm-multicenter-pilot-study
#13
Yasushi Honda, Takaomi Kessoku, Yoshio Sumida, Takashi Kobayashi, Takayuki Kato, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Koji Fujita, Masato Yoneda, Koshi Kataoka, Masataka Taguri, Takeharu Yamanaka, Yuya Seko, Saiyu Tanaka, Satoru Saito, Masafumi Ono, Satoshi Oeda, Yuichiro Eguchi, Wataru Aoi, Kenji Sato, Yoshito Itoh, Atsushi Nakajima
BACKGROUND: Glutathione plays crucial roles in the detoxification and antioxidant systems of cells and has been used to treat acute poisoning and chronic liver diseases by intravenous injection. This is a first study examining the therapeutic effects of oral administration of glutathione in patients with nonalcoholic fatty liver disease (NAFLD). METHODS: The study was an open label, single arm, multicenter, pilot trial. Thirty-four NAFLD patients diagnosed using ultrasonography were prospectively evaluated...
August 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28780603/early-detection-of-exercise-induced-muscle-damage-using-elastography
#14
Lilian Lacourpaille, Antoine Nordez, François Hug, Valentin Doguet, Ricardo Andrade, Gaël Guilhem
PURPOSE: This study aimed to determine whether an increase in muscle shear modulus measured 30 min after eccentric exercise (30 min) reflects the magnitude of force deficit measured 48-h post-exercise (48 H). METHODS: A total of 53 healthy participants were distributed in five groups. Four groups performed either repeated eccentric elbow flexions or knee extensions at either a low or high load. A fifth group performed repeated concentric elbow flexions (control load)...
August 5, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28779596/machine-learning-based-classification-of-real-time-tissue-elastography-for-hepatic-fibrosis-in-patients-with-chronic-hepatitis-b
#15
Yang Chen, Yan Luo, Wei Huang, Die Hu, Rong-Qin Zheng, Shu-Zhen Cong, Fan-Kun Meng, Hong Yang, Hong-Jun Lin, Yan Sun, Xiu-Yan Wang, Tao Wu, Jie Ren, Shu-Fang Pei, Ying Zheng, Yun He, Yu Hu, Na Yang, Hongmei Yan
Hepatic fibrosis is a common middle stage of the pathological processes of chronic liver diseases. Clinical intervention during the early stages of hepatic fibrosis can slow the development of liver cirrhosis and reduce the risk of developing liver cancer. Performing a liver biopsy, the gold standard for viral liver disease management, has drawbacks such as invasiveness and a relatively high sampling error rate. Real-time tissue elastography (RTE), one of the most recently developed technologies, might be promising imaging technology because it is both noninvasive and provides accurate assessments of hepatic fibrosis...
July 20, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28779402/nomogram-for-individualised-prediction-of-liver-failure-risk-after-hepatectomy-in-patients-with-resectable-hepatocellular-carcinoma-the-evidence-from-ultrasound-data
#16
Hao Hu, Hong Han, Xi Kun Han, Wen Ping Wang, Hong Ding
OBJECTIVES: This study sought to develop a clinical nomogram for predicting post-hepatectomy liver failure (PHLF) among patients with resectable hepatocellular carcinoma (HCC). METHODS: The nomogram was established based on data obtained from a prospective study on 136 consecutive patients with resectable HCC undergoing hepatectomy from January 2015 to December 2015 in our centre. Another 80 patients in our centre served as an independent internal validation set...
August 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28778388/quantifying-extensibility-of-rotator-cuff-muscle-with-tendon-rupture-using-shear-wave-elastography-a-cadaveric-study
#17
Taku Hatta, Hugo Giambini, Yoshiaki Itoigawa, Alexander W Hooke, John W Sperling, Scott P Steinmann, Eiji Itoi, Kai-Nan An
Surgical repair for large rotator cuff tear remains challenging due to tear size, altered muscle mechanical properties, and poor musculotendinous extensibility. Insufficient extensibility might lead to an incomplete reconstruction; moreover, excessive stresses after repair may result in repair failure without healing. Therefore, estimates of extensibility of cuff muscles can help in pre-surgical planning to prevent unexpected scenarios during surgery. The purpose of this study was to determine if quantified mechanical properties of the supraspinatus muscle using shear wave elastography (SWE) could be used to predict the extensibility of the musculotendinous unit on cadaveric specimens...
July 21, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28778194/prevalence-of-chronic-hepatitis-b-virus-infection-and-infrastructure-for-its-diagnosis-in-madagascar-implication-for-the-who-s-elimination-strategy
#18
Soa Fy Andriamandimby, Marie-Marie Olive, Yusuke Shimakawa, Fanjasoa Rakotomanana, Iony Manitra Razanajatovo, Tsarasoa Malala Andrianinarivomanana, Jean-Pierre Ravalohery, Seta Andriamamonjy, Christophe Rogier, Jean-Michel Héraud
BACKGROUND: WHO developed a global strategy to eliminate hepatitis B by 2030 and set target to treat 80% of people with chronic hepatitis B virus (HBV) infection eligible for antiviral treatment. As a first step to achieve this goal, it is essential to conduct a situation analysis that is fundamental to designing national hepatitis plans. We therefore estimated the prevalence of chronic HBV infection, and described the existing infrastructure for HBV diagnosis in Madagascar. METHODS: We conducted a stratified multi-stage serosurvey of hepatitis B surface antigen (HBsAg) in adults aged ≥18 years using 28 sentinel surveillance sites located throughout the country...
August 4, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28777887/role-of-2d-shear-wave-elastography-in-the-assessment-of-chronic-liver-diseases
#19
EDITORIAL
Siddharth Singh, Rohit Loomba
No abstract text is available yet for this article.
August 4, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28777745/simultaneous-3d-mr-elastography-of-the-in-vivo-mouse-brain
#20
Steven P Kearney, Shreyan Majumdar, Thomas J Royston, Dieter Klatt
The feasibility of sample interval modulation (SLIM) magnetic resonance elastography (MRE) for the in vivo mouse brain is assessed, and an alternative SLIM-MRE encoding method is introduced. In SLIM-MRE, the phase accumulation for each motion direction is encoded simultaneously by varying either the start time of the motion encoding gradient (MEG), SLIM-phase constant (SLIM-PC), or the initial phase of the MEG, SLIM-phase varying (SLIM-PV). SLIM-PC provides gradient moment nulling, but the mutual gradient shift necessitates increased echo time (TE)...
August 4, 2017: Physics in Medicine and Biology
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