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https://www.readbyqxmd.com/read/28936407/current-modalities-of-fibrosis-assessment-in-non-alcoholic-fatty-liver-disease
#1
REVIEW
Mark Cc Cheah, Arthur J McCullough, George Boon-Bee Goh
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global health concern. In the subset of NAFLD patients with non-alcoholic steatohepatitis (NASH), the presence of significant fibrosis at index assessment is associated with poor prognosis and increased mortality. Hence, there is a growing need to accurately assess and stage fibrosis. Liver biopsy, the current gold standard, has limitations with sampling error and is invasive, with associated inherent risk. This has led to a host of non-invasive means of assessing fibrosis, which has garnered relevance in a disease that requires serial assessment of fibrosis longitudinally over time...
September 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/28935983/model-based-vascular-elastography-improves-the-detection-of-flow-induced-carotid-artery-remodeling-in-mice
#2
Vyacheslav A Korshunov, Hexuan Wang, Rifat Ahmed, Deanne M Mickelsen, Qian Zhou, Chen Yan, Marvin M Doyley
Increased arterial thickness measured with ultrasound correlates with future cardiovascular events, but conventional ultrasound imaging techniques cannot distinguish between intima, media, or atherosclerotic plaque in the carotid artery. In this work, we evaluated how well vascular elastography can detect intimal changes in a mouse model of carotid remodeling. We ligated the left external and internal branches of the carotid artery of male FVB mice and performed sham operations for 2 weeks. High-resolution ultrasound imaging accurately detected lower blood velocities and low blood volume flow in the carotid arteries after ligation in FVB mice...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935453/intraoperative-real-time-tissue-elastography-during-laparoscopic-hepatectomy
#3
Yuta Kobayashi, Kiyohiko Omichi, Yoshikuni Kawaguchi, Junichi Arita, Nobuhisa Akamatsu, Junichi Kaneko, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo
BACKGROUND: Real-time tissue elastography during open hepatectomy facilitates the differential diagnosis of liver tumors by providing information on elasticity. This study investigated the utility of intraoperative real-time tissue elastography (IORTE) during laparoscopic hepatectomy (LH). METHODS: Between 2012 and 2014, IORTE was performed during LH for 21 hepatocellular carcinomas (HCCs), 16 adenocarcinomas and 5 other tumors in 32 patients. The elasticity images were classified into six categories according to the modified criteria on the elasticity type of liver tumors, in which type 1 tumors show more strain than the surrounding liver and type 6 tumors no strain...
September 18, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/28934812/prediction-of-pathological-complete-response-to-neoadjuvant-chemotherapy-for-primary-breast-cancer-comparing-interim-ultrasound-shear-wave-elastography-and-mri
#4
Andrew Evans, Patsy Whelehan, Alastair Thompson, Colin Purdie, Lee Jordan, Jane Macaskill, Shelley Waugh, Frances Fuller-Pace, Katrin Brauer, Sarah Vinnicombe
Background Prediction of pathological complete response (pCR) of primary breast cancer to neoadjuvant chemotherapy (NACT) may influence planned surgical approaches in the breast and axilla. The aim of this project is to assess the value of interim shear wave elastography (SWE), ultrasound (US) and magnetic resonance imaging (MRI) after 3 cycles in predicting pCR. Methods 64 patients receiving NACT had baseline and interim US, SWE and MRI examinations. The mean lesion stiffness at SWE, US and MRI diameter was measured at both time points...
September 21, 2017: Ultraschall in der Medizin
https://www.readbyqxmd.com/read/28934633/association-of-low-back-pain-with-muscle-stiffness-and-muscle-mass-of-the-lumbar-back-muscles-and-sagittal-spinal-alignment-in-young-and-middle-aged-medical-workers
#5
Mitsuhiro Masaki, Tomoki Aoyama, Takashi Murakami, Ko Yanase, Xiang Ji, Hiroshige Tateuchi, Noriaki Ichihashi
BACKGROUND: Muscle stiffness of the lumbar back muscles in low back pain (LBP) patients has not been clearly elucidated because quantitative assessment of the stiffness of individual muscles was conventionally difficult. This study aimed to examine the association of LBP with muscle stiffness assessed using ultrasonic shear wave elastography (SWE) and muscle mass of the lumbar back muscle, and spinal alignment in young and middle-aged medical workers. METHODS: The study comprised 23 asymptomatic medical workers [control (CTR) group] and 9 medical workers with LBP (LBP group)...
September 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28932977/hepatic-stiffness-using-shear-wave-elastography-and-the-related-factors-for-a-fontan-circulation
#6
Seong-Ook Kim, Sang-Yun Lee, So-Ick Jang, Soo-Jin Park, Hye-Won Kwon, Seong-Ho Kim, Chang-Ha Lee, Eun-Seok Choi, Seong-Kyu Cho, Sun-Hwa Hong, Yang-Min Kim
Hepatic problems related to a Fontan circulation have been highlighted and elastography using ultrasound is a non-invasive tool that can measure the severity of hepatic stiffness. We investigated the hepatic stiffness using shear wave elastography (SWE) and related factors in patients with a Fontan circulation. This study enrolled 64 patients with a Fontan circulation who underwent cardiac catheterization and abdominal ultrasound from 2011 to 2015. The correlation between the laboratory tests, hemodynamic factors by cardiac catheterization, and SWE was evaluated...
September 21, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28932088/real-time-endoscopic-ultrasound-elastography-and-strain-ratio-in-the-diagnosis-of-solid-pancreatic-lesions
#7
Hussein Okasha, Shaimaa Elkholy, Ramy El-Sayed, Mohamed-Naguib Wifi, Mohamed El-Nady, Walid El-Nabawi, Waleed A El-Dayem, Mohamed I Radwan, Ali Farag, Yahya El-Sherif, Emad Al-Gemeie, Ahmed Salman, Mohamed El-Sherbiny, Ahmed El-Mazny, Reem E Mahdy
AIM: To evaluate the accuracy of the elastography score combined to the strain ratio in the diagnosis of solid pancreatic lesions (SPL). METHODS: A total of 172 patients with SPL identified by endoscopic ultrasound were enrolled in the study to evaluate the efficacy of elastography and strain ratio in differentiating malignant from benign lesions. The semi quantitative score of elastography was represented by the strain ratio method. Two areas were selected, area (A) representing the region of interest and area (B) representing the normal area...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28927107/comparison-of-the-effectiveness-of-ultrasound-elastography-with-that-of-conventional-ultrasound-for-differential-diagnosis-of-thyroid-lesions-with-suspicious-ultrasound-features
#8
Jinru Yang, Yan Song, Wei Wei, Litao Ruan, Hong Ai
Ultrasound elastography (USE) has been used for quantitative imaging since the early 1990s. The aim of the present study was to compare the effectiveness of USE with that of conventional ultrasound in the differential diagnosis of benign vs. malignant thyroid nodules. USE was performed on 150 thyroid nodules in 123 patients. USE demonstrated a lower grade of elasticity (grade I/II) in 86% of benign nodules and a decreased strain ratio (2.30±1.01) compared with malignant nodules. USE of malignant nodules exhibited a higher grade of elasticity (grade III/IV) in 90% of nodules and an increased strain ratio (6...
September 2017: Oncology Letters
https://www.readbyqxmd.com/read/28922441/evaluation-of-2d-shear-wave-elastography-for-characterisation-of-focal-liver-lesions
#9
Ludmila Gerber, Daniel Fitting, Kajana Srikantharajah, Nina Weiler, Georgia Kyriakidou, Joerg Bojunga, Falko Schulze, Dimitra Bon, Stefan Zeuzem, Mireen Friedrich-Rust
BACKGROUND AND AIM: This is a prospective study for evaluation of 2D-shear wave elastography (2D-SWE) for characterisation and differentiation of benign und malignant focal liver lesions (FLLs). METHODS: The patients referred to our ultrasound unit were prospectively included. B-mode ultrasound and 2D-SWE (Aixplorer® France) were performed for one FLL in each patient. Liver histology and/or contrast-enhanced imaging were used as a reference method. RESULTS: 140 patients with FLL were included...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28922440/real-life-use-of-3-direct-acting-antiviral-regimen-in-a-large-cohort-of-patients-with-genotype-1b-hcv-compensated-cirrhosis
#10
Liana Gheorghe, Speranta Iacob, Manuela Curescu, Ciprian Brisc, Cristina Cijevschi, Florin Caruntu, Carol Stanciu, Iulia Simionov, Ioan Sporea, Cristian Gheorghe, Razvan Iacob, Victoria Arama, Roxana Sirli, Anca Trifan
BACKGROUND AND AIMS: Ombitasvir/Paritaprevir/ritonavir/Dasabuvir (OBV/PTV/r+DSV) is one of the elective direct-acting antivirals (DAAs) recommended by international guidelines and the only one covered by the National Insurance System in Romania until November 2016. Our aim was to present the first prospective Romanian cohort evaluating the effectiveness and safety in clinical practice of this 3DAA combination in patients with HCV genotype-1b Child A liver cirrhosis. METHODS: 681 patients received OBV/PTV/r+DSV+RBV for 12 weeks and were assessed clinically and biologically at baseline, week 4, 8, 12 (end of treatment, EOT), and 12 weeks after therapy (sustained viral response, SVR)...
September 2017: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/28919161/magnetic-resonance-elastography-of-the-brain-a-comparison-between-pigs-and-humans
#11
Johannes Weickenmeier, Mehmet Kurt, Efe Ozkaya, Max Wintermark, Kim Butts Pauly, Ellen Kuhl
Magnetic resonance elastography holds promise as a non-invasive, easy-to-use, in vivo biomarker for neurodegenerative diseases. Throughout the past decade, pigs have gained increased popularity as large animal models for human neurodegeneration. However, the volume of a pig brain is an order of magnitude smaller than the human brain, its skull is 40% thicker, and its head is about twice as big. This raises the question to which extent established vibration devices, actuation frequencies, and analysis tools for humans translate to large animal studies in pigs...
August 26, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28918798/new-imaging-techniques-endoscopic-ultrasound-guided-elastography
#12
REVIEW
Julio Iglesias-García, Jose Lariño-Noia, Juan Enrique Domínguez-Muñoz
Endoscopic ultrasound (EUS) is a major imaging method in the management of several diseases of the gastrointestinal tract and surrounding structures. Elastography is a novel technique providing additional information to standard B-mode imaging on the tissue stiffness. Elastography can be performed under EUS guidance. This method has proven to be an accurate and additional tool in the evaluation of pancreatic diseases and lymph nodes analysis. Possible uses include the study of liver lesions, subepithelial masses, and many more...
October 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28915103/mr-spectroscopy-derived-proton-density-fat-fraction-is-superior-to-controlled-attenuation-parameter-for-detecting-and-grading-hepatic-steatosis
#13
Jurgen Henk Runge, Loek Pieter Smits, Joanne Verheij, Annekatrien Depla, Sjoerd Douwe Kuiken, Bert Cornelis Baak, Aart Johannes Nederveen, Ulrich Beuers, Jaap Stoker
Purpose To prospectively compare the diagnostic accuracy of controlled attenuation parameter (CAP) obtained with transient elastography and proton density fat fraction (PDFF) obtained with proton magnetic resonance (MR) spectroscopy with results of liver biopsy in a cohort of adult patients suspected of having nonalcoholic fatty liver disease (NAFLD). Materials and Methods The institutional review board approved this study. Informed consent was obtained from all patients. The authors evaluated 55 patients suspected of having NAFLD (40 men, 15 women)...
September 15, 2017: Radiology
https://www.readbyqxmd.com/read/28914407/association-of-fetuin-b-with-markers-of-liver-fibrosis-in-nonalcoholic-fatty-liver-disease
#14
Thomas Ebert, Nicolas Linder, Alexander Schaudinn, Harald Busse, Joachim Berger, Ralf Lichtinghagen, Volker Keim, Johannes Wiegand, Thomas Karlas
OBJECTIVE: The liver-derived plasma protein fetuin B is associated with nonalcoholic fatty liver disease (NAFLD) and impaired glucose homeostasis in mice. However, its association with non-invasive ultrasound- and magnetic resonance (MR)-based markers of liver fibrosis and steatosis, the enhanced liver fibrosis (ELF) score, liver biopsy, as well as rs738409 in PNPLA3, has not been elucidated in NAFLD, so far. DESIGN AND METHODS: The association of circulating fetuin B and transient elastography (TE), controlled attenuation parameter (CAP), (1)H-MR-spectroscopy, the ELF score, liver biopsy, as well as risk alleles in rs738409 in PNPLA3, was studied in 101 NAFLD patients as compared to 15 healthy controls...
September 15, 2017: Endocrine
https://www.readbyqxmd.com/read/28906010/serial-changes-in-liver-stiffness-and-controlled-attenuation-parameter-following-direct-acting-antiviral-therapy-against-hepatitis-c-virus-genotype-1b
#15
Nobuhiko Ogasawara, Masahiro Kobayashi, Norio Akuta, Yoko Kominami, Shunichiro Fujiyama, Yusuke Kawamura, Hitomi Sezaki, Tetsuya Hosaka, Fumitaka Suzuki, Satoshi Saitoh, Yoshiyuki Suzuki, Yasuji Arase, Kenji Ikeda, Mariko Kobayashi, Hiromitsu Kumada
Little information is available on the impact of direct-acting antiviral (DAA) therapy on changes in liver fibrosis and steatosis. Liver stiffness (LS) and controlled attenuation parameter (CAP) values were evaluated using transient elastography. The study subjects were 214 elderly patients infected with HCV genotype 1b who received 24-week daclatasvir and asunaprevir dual therapy. All patients of this retrospective study had no hepatocellular carcinoma before and during DAA therapy. LS and CAP were assessed before treatment (baseline), at end of treatment (EOT), and at 24, 48, 72 weeks (W) after EOT...
September 14, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28906009/does-lesion-size-affect-the-value-of-shear-wave-elastography-for-differentiating-between-benign-and-malignant-thyroid-nodules
#16
Fen Wang, Cai Chang, Min Chen, Yi Gao, Ya-Ling Chen, Shi-Chong Zhou, Jia-Wei Li, Wen-Xiang Zhi
OBJECTIVES: We aimed to investigate the diagnostic performance of shear wave elastography (SWE) combined with conventional ultrasonography (US) for differentiating between benign and malignant thyroid nodules of different sizes. METHODS: A total of 445 thyroid nodules from 445 patients were divided into 3 groups based on diameter (group 1, ≤ 10 mm; group 2, 10-20 mm; and group 3, > 20 mm). The mean elasticity index of the whole lesion was automatically calculated, and the threshold for differentiation between benign and malignant nodules was constructed by a receiver operating characteristic curve analysis...
September 14, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/28905143/the-value-of-quantitative-shear-wave-elastography-in-differentiating-the-cervical-lymph-nodes-in-patients-with-thyroid-nodules
#17
Jun You, Juan Chen, Feixiang Xiang, Yue Song, Simai Khamis, Chengfa Lu, Qing Lv, Yanrong Zhang, Mingxing Xie
PURPOSE: This study aimed at evaluating the diagnostic performance of quantitative shear wave elastography (SWE) in differentiating metastatic cervical lymph nodes from benign nodes in patients with thyroid nodules. METHODS: One hundred and forty-one cervical lymph nodes from 39 patients with thyroid nodules that were diagnosed as papillary thyroid cancer had been imaged with SWE. The shear elasticity modulus, which indicates the stiffness of the lymph nodes, was measured in terms of maximum shear elasticity modulus (maxSM), minimum shear elasticity modulus (minSM), mean shear elasticity modulus (meanSM), and standard deviation (SD) of the shear elasticity modulus...
September 13, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28900767/quantitative-assessment-of-muscular-stiffness-in-children-with-cerebral-palsy-using-acoustic-radiation-force-impulse-arfi-ultrasound-elastography
#18
Meltem Ceyhan Bilgici, Tumay Bekci, Yasemin Ulus, Hamit Ozyurek, Omer Faruk Aydin, Leman Tomak, Mustafa Bekir Selcuk
PURPOSE: To evaluate the feasibility of quantitative analysis of muscle stiffness in the medial gastrocnemius muscle (GCM) by acoustic radiation force impulse (ARFI) ultrasound elastography in children with spastic cerebral palsy (CP). METHODS: Seventeen children with spastic CP and 25 healthy children participated in the study between the years 2016-2017. The medial GCM in the CP group was assessed using the Modified Ashworth Scale (MAS) by a physiatrist. ARFI was used to measure the shear-wave velocities (SWVs) of the medial GCM...
September 12, 2017: Journal of Medical Ultrasonics
https://www.readbyqxmd.com/read/28900566/transversus-abdominis-elasticity-during-various-exercises-a-shear-wave-ultrasound-elastography-study
#19
Kuniaki Hirayama, Ryota Akagi, Yuki Moniwa, Junichi Okada, Hideyuki Takahashi
BACKGROUND: Although the transversus abdominis (TrA) is considered to play a significant role in maintaining trunk stability, there is little information regarding the type of exercise that best facilitates the development of tension in the TrA. Muscle elasticity shows a strong association with muscle tension. Shear wave ultrasound elastography provides a means by which the tension of TrA can be noninvasively estimated, by quantifying it's elasticity. PURPOSE: The purpose of this study was to examine the TrA elasticity during several exercises as measured by shear wave ultrasound elastography, and to determine which of the studied exercises demonstrated the greatest tension...
August 2017: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/28900522/point-shear-wave-ultrasound-elastography-with-esaote-compared-to-real-time-2d-shear-wave-elastography-with-supersonic-imagine-for-the-quantification-of-liver-stiffness
#20
L Mulazzani, V Salvatore, F Ravaioli, G Allegretti, F Matassoni, R Granata, A Ferrarini, H Stefanescu, Fabio Piscaglia
PURPOSE: Different shear wave elastography (SWE) machines able to quantify liver stiffness (LS) have been recently introduced by various companies. The aim of this study was to investigate the agreement between point SWE with Esaote MyLab Twice (pSWE.ESA) and 2D SWE with Aixplorer SuperSonic (2D SWE.SSI). Moreover, we assessed the correlation of these machines with Fibroscan in a subgroup of patients. METHODS: A total of 81 liver disease patients and 27 subjects without liver disease accessing the ultrasound lab were considered...
September 2017: Journal of Ultrasound
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