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https://www.readbyqxmd.com/read/29451048/impact-of-radon-and-combinatory-radon-carbon-dioxide-spa-on-pain-and-hypertension-results-from-the-explorative-rad-on01-study
#1
Paul F Rühle, Gerhart Klein, Tatjana Rung, Hong Tiep Phan, Claudia Fournier, Rainer Fietkau, Udo S Gaipl, Benjamin Frey
OBJECTIVES: Therapies with low doses of radon have beneficial effects on patients suffering from chronic painful degenerative and inflammatory diseases. We already showed that this is accompanied by systemic immune modulations. We here focus on pain reducing effects of very low doses of radon by adding carbon dioxide water and its impact on heart rate variability (HRV), blood pressure and free radicals. METHODS: 100 patients receiving radon spa (1.200 Bq/l at 34°C or 600 Bq/l, 1 g/l CO 2 at 34°C) were monitored before and at three different time points after therapy...
February 16, 2018: Modern Rheumatology
https://www.readbyqxmd.com/read/29448184/spontaneous-alveolar-bone-loss-after-4nqo-exposure-in-wistar-rats
#2
Harry J R Oballe, Francisco Wilker M G Muniz, Cheyenne C Bueno, Isadora P Klein, Vinicius C Carrard, Cassiano K Rösing, Eduardo J Gaio
OBJECTIVE: This study evaluated the effect of an experimental carcinogenic, 4-Nitroquinoline 1-oxide (4NQO), in the spontaneous alveolar bone loss (ABL) in an animal model. DESIGN: Twenty-two male Wistar rats were included in this study. They were randomly divided into two groups: the control group (n = 10) received food and water ad libitum, and the test group (n = 12) receive the same food; however, 25 ppm of 4NQO was diluted in the drinking water. All animals were euthanized after 20 weeks, and the tongues were removed and analyzed macroscopically to determine the presence of oral mucosal lesions...
February 7, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29444673/effect-of-tt-farnesol-and-myricetin-on-in-vitro-biofilm-formed-by-streptococcus-mutans-and-candida-albicans
#3
Guilherme Roncari Rocha, Elkin Jahir Florez Salamanca, Ana Letícia de Barros, Carmélia Isabel Vitorino Lobo, Marlise Inêz Klein
BACKGROUND: Dental caries is considered a multifactorial disease, in which microorganisms play an important role. The diet is decisive in the biofilm formation because it provides the necessary resources for cellular growth and exopolysaccharides synthesis. Exopolysaccharides are the main components of the extracellular matrix (ECM). The ECM provides a 3D structure, support for the microorganisms and form diffusion-limited environments (acidic niches) that cause demineralization of the dental enamel...
February 14, 2018: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29443114/causes-and-circumstances-of-death-in-a-neonatal-unit-over-20-years
#4
Marissa C Michel, Tarah T Colaizy, Jonathan M Klein, Jeffrey L Segar, Edward F Bell
BackgroundWe examined changes in the causes and circumstances of death in our neonatal intensive care unit (NICU) over 20 years.MethodsFor 551 infants who died between 1993 and 2013, the principal cause of death was recorded. Circumstances of death were assigned to one of the following four categories: death following cardiopulmonary resuscitation (CPR), death while being mechanically ventilated without CPR, death after withholding life-support interventions, and death after withdrawal of life support. Data were compared across four 5-year epochs...
February 14, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29442271/exploring-variability-in-basal-ganglia-connectivity-with-functional-mri-in-healthy-aging
#5
Ludovica Griffanti, Philipp Stratmann, Michal Rolinski, Nicola Filippini, Enikő Zsoldos, Abda Mahmood, Giovanna Zamboni, Gwenaëlle Douaud, Johannes C Klein, Mika Kivimäki, Archana Singh-Manoux, Michele T Hu, Klaus P Ebmeier, Clare E Mackay
Changes in functional connectivity (FC) measured using resting state fMRI within the basal ganglia network (BGN) have been observed in pathologies with altered neurotransmitter systems and conditions involving motor control and dopaminergic processes. However, less is known about non-disease factors affecting FC in the BGN. The aim of this study was to examine associations of FC within the BGN with dopaminergic processes in healthy older adults. We explored the relationship between FC in the BGN and variables related to demographics, impulsive behavior, self-paced tasks, mood, and motor correlates in 486 participants in the Whitehall-II imaging sub-study using both region-of-interest- and voxel-based approaches...
February 13, 2018: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29439562/ion-channel-sensing-are-fluctuations-the-crux-of-the-matter
#6
Marina A Kasimova, Aysenur Yazici, Yevgen Yudin, Daniele Granata, Michael L Klein, Tibor Rohacs, Vincenzo Carnevale
The non-selective cation channel TRPV1 is responsible for transducing noxious stimuli into action potentials propagating through peripheral nerves. It is activated by temperatures greater than 43 °C, while remaining completely non-conductive at temperatures lower than this threshold. The origin of this sharp response, which makes TRPV1 a biological temperature sensor, is not understood. Here we used molecular dynamics simulations and free energy calculations to characterize the molecular determinants of the transition between non-conductive and conductive states...
February 13, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29438700/targeting-the-senescence-overriding-cooperative-activity-of-structurally-unrelated-h3k9-demethylases-in-melanoma
#7
Yong Yu, Kolja Schleich, Bin Yue, Sujuan Ji, Philipp Lohneis, Kristel Kemper, Mark S Silvis, Nouar Qutob, Ellen van Rooijen, Melanie Werner-Klein, Lianjie Li, Dhriti Dhawan, Svenja Meierjohann, Maurice Reimann, Abdel Elkahloun, Steffi Treitschke, Bernd Dörken, Christian Speck, Frédérick A Mallette, Leonard I Zon, Sheri L Holmen, Daniel S Peeper, Yardena Samuels, Clemens A Schmitt, Soyoung Lee
Oncogene-induced senescence, e.g., in melanocytic nevi, terminates the expansion of pre-malignant cells via transcriptional silencing of proliferation-related genes due to decoration of their promoters with repressive trimethylated histone H3 lysine 9 (H3K9) marks. We show here that structurally distinct H3K9-active demethylases-the lysine-specific demethylase-1 (LSD1) and several Jumonji C domain-containing moieties (such as JMJD2C)-disable senescence and permit Ras/Braf-evoked transformation. In mouse and zebrafish models, enforced LSD1 or JMJD2C expression promoted Braf-V600E-driven melanomagenesis...
February 12, 2018: Cancer Cell
https://www.readbyqxmd.com/read/29436110/catastrophizing-pain-and-traumatic-stress-symptoms-following-burns-a-prospective-study
#8
N E Van Loey, I Klein, A E E de Jong, H W C Hofland, E Vandermeulen, I M Engelhard
BACKGROUND: Pain and PTSD symptoms are significant problems in the aftermath of a burn injury and they often co-occur. Catastrophizing has been linked to both phenomena. The aim of this study was to investigate the underlying role of catastrophizing in PTSD symptoms and pain following burns. METHODS: This prospective study included 216 patients with burns. PTSD symptoms and pain were measured during hospitalization (T1) and 6 (T2) and 12 months (T3) postburn. The Impact of Event Scale-Revised (IES-R) indexed PTSD symptoms...
February 13, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29436039/cortical-structural-involvement-and-cognitive-dysfunction-in-early-parkinson-s-disease
#9
J C Klein, M Rolinski, L Griffanti, K Szewczyk-Krolikowski, F Baig, C Ruffmann, A R Groves, R A L Menke, M T Hu, C Mackay
Magnetic resonance imaging (MRI) studies in early Parkinson's disease (PD) have shown promise in the detection of disease-related brain changes in the white and deep grey matter. We set out to establish whether intrinsic cortical involvement in early PD can be detected with quantitative MRI. We collected a rich, multi-modal dataset, including diffusion MRI, T1 relaxometry and cortical morphometry, in 20 patients with early PD (disease duration, 1.9 ± 0.97 years, Hoehn & Yahr 1-2) and in 19 matched controls...
February 13, 2018: NMR in Biomedicine
https://www.readbyqxmd.com/read/29435980/the-diabetes-drug-liraglutide-reverses-cognitive-impairment-in-mice-and-attenuates-insulin-receptor-and-synaptic-pathology-in-a-non-human-primate-model-of-alzheimer-s-disease
#10
Andre F Batista, Leticia Forny-Germano, Julia R Clarke, Natalia M Lyra E Silva, Jordano Brito-Moreira, Susan E Boehnke, Andrew Winterborn, Brian C Coe, Ann Lablans, Juliana F Vital, Suelen A Marques, Ana M B Martinez, Matthias Gralle, Christian Holscher, William L Klein, Jean-Christophe Houzel, Sergio T Ferreira, Douglas P Munoz, Fernanda G De Felice
Alzheimer's disease (AD) is a devastating neurological disorder that still lacks an effective treatment, and this has stimulated an intense pursuit of disease-modifying therapeutics. Given the increasingly recognized link between AD and defective brain insulin signaling, we investigated the actions of liraglutide, a glucagon-like peptide-1 (GLP-1) analog marketed for treatment of type 2 diabetes, in experimental models of AD. Insulin receptor pathology is an important feature of AD brains that impairs the neuroprotective actions of central insulin signaling...
February 12, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29428596/small-molecule-pgc-1%C3%AE-1-protein-stabilizers-induce-adipocyte-ucp1-expression-and-uncoupled-mitochondrial-respiration
#11
A T Pettersson-Klein, M Izadi, D M S Ferreira, I Cervenka, J C Correia, V Martinez-Redondo, M Southern, M Cameron, T Kamenecka, L Z Agudelo, M Porsmyr-Palmertz, U Martens, B Lundgren, M Otrocka, A Jenmalm-Jensen, P R Griffin, J L Ruas
OBJECTIVE: The peroxisome proliferator-activated receptor-γ coactivator-1α1 (PGC-1α1) regulates genes involved in energy metabolism. Increasing adipose tissue energy expenditure through PGC-1α1 activation is potentially beneficial for systemic metabolism. Pharmacological PGC-1α1 activators could be valuable tools in the fight against obesity and metabolic disease. Finding such compounds has been challenging partly because PGC-1α1 is a transcriptional coactivator with no known ligand-binding properties...
February 3, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29422604/genome-wide-meta-analysis-identifies-five-new-susceptibility-loci-for-pancreatic-cancer
#12
Alison P Klein, Brian M Wolpin, Harvey A Risch, Rachael Z Stolzenberg-Solomon, Evelina Mocci, Mingfeng Zhang, Federico Canzian, Erica J Childs, Jason W Hoskins, Ashley Jermusyk, Jun Zhong, Fei Chen, Demetrius Albanes, Gabriella Andreotti, Alan A Arslan, Ana Babic, William R Bamlet, Laura Beane-Freeman, Sonja I Berndt, Amanda Blackford, Michael Borges, Ayelet Borgida, Paige M Bracci, Lauren Brais, Paul Brennan, Hermann Brenner, Bas Bueno-de-Mesquita, Julie Buring, Daniele Campa, Gabriele Capurso, Giulia Martina Cavestro, Kari G Chaffee, Charles C Chung, Sean Cleary, Michelle Cotterchio, Frederike Dijk, Eric J Duell, Lenka Foretova, Charles Fuchs, Niccola Funel, Steven Gallinger, J Michael M Gaziano, Maria Gazouli, Graham G Giles, Edward Giovannucci, Michael Goggins, Gary E Goodman, Phyllis J Goodman, Thilo Hackert, Christopher Haiman, Patricia Hartge, Manal Hasan, Peter Hegyi, Kathy J Helzlsouer, Joseph Herman, Ivana Holcatova, Elizabeth A Holly, Robert Hoover, Rayjean J Hung, Eric J Jacobs, Krzysztof Jamroziak, Vladimir Janout, Rudolf Kaaks, Kay-Tee Khaw, Eric A Klein, Manolis Kogevinas, Charles Kooperberg, Matthew H Kulke, Juozas Kupcinskas, Robert J Kurtz, Daniel Laheru, Stefano Landi, Rita T Lawlor, I-Min Lee, Loic LeMarchand, Lingeng Lu, Núria Malats, Andrea Mambrini, Satu Mannisto, Roger L Milne, Beatrice Mohelníková-Duchoňová, Rachel E Neale, John P Neoptolemos, Ann L Oberg, Sara H Olson, Irene Orlow, Claudio Pasquali, Alpa V Patel, Ulrike Peters, Raffaele Pezzilli, Miquel Porta, Francisco X Real, Nathaniel Rothman, Ghislaine Scelo, Howard D Sesso, Gianluca Severi, Xiao-Ou Shu, Debra Silverman, Jill P Smith, Pavel Soucek, Malin Sund, Renata Talar-Wojnarowska, Francesca Tavano, Mark D Thornquist, Geoffrey S Tobias, Stephen K Van Den Eeden, Yogesh Vashist, Kala Visvanathan, Pavel Vodicka, Jean Wactawski-Wende, Zhaoming Wang, Nicolas Wentzensen, Emily White, Herbert Yu, Kai Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Peter Kraft, Donghui Li, Stephen Chanock, Ofure Obazee, Gloria M Petersen, Laufey T Amundadottir
In 2020, 146,063 deaths due to pancreatic cancer are estimated to occur in Europe and the United States combined. To identify common susceptibility alleles, we performed the largest pancreatic cancer GWAS to date, including 9040 patients and 12,496 controls of European ancestry from the Pancreatic Cancer Cohort Consortium (PanScan) and the Pancreatic Cancer Case-Control Consortium (PanC4). Here, we find significant evidence of a novel association at rs78417682 (7p12/TNS3, P = 4.35 × 10-8). Replication of 10 promising signals in up to 2737 patients and 4752 controls from the PANcreatic Disease ReseArch (PANDoRA) consortium yields new genome-wide significant loci: rs13303010 at 1p36...
February 8, 2018: Nature Communications
https://www.readbyqxmd.com/read/29421874/the-different-faces-of-4-pyrimidinyl-functionalized-4-2-6-4-terpyridines-metal-organic-assemblies-from-solution-and-on-au-111-and-cu-111-surface-platforms
#13
Thomas Nijs, Y Maximilian Klein, S Fatemeh Mousavi, Aisha Ahsan, Sylwia Nowakowska, Edwin C Constable, Catherine Elizabeth Housecroft, Thomas A Jung
A comparative investigation of crystal growth from solution and on-surface assembly in vacuo between copper and three 4'-(2-R-pyrimidin-5-yl)-4,2':6',4''-terpyridines with R = H (1), Me (2) or Et (3) is presented. In solution, ligand 3 combines with copper(II) acetate or copper(I) triflate in MeOH solution to give [Cu2(OAc)4(3)]n or {[Cu(3)(OMe)(MeOH)][CF3SO3].MeOH}n. In [Cu2(OAc)4(3)]n, paddle-wheel {Cu2(μ-OAc)4} nodes direct the assembly of 1D-zigzag chains which pack into 2D sheets. In {[Cu(3)(OMe)(MeOH)][CF3SO3]...
February 9, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29419568/recent-abacavir-use-increases-risk-for-types-1-and-2-myocardial-infarctions-among-adults-with-hiv
#14
Richard A Elion, Keri N Althoff, Jinbing Zhang, Richard D Moore, Stephen J Gange, Mari M Kitahata, Heidi M Crane, Daniel R Drozd, James H Stein, Marina B Klein, Joseph J Eron, Michael J Silverberg, William C Mathews, Amy C Justice, Timothy R Sterling, Charles S Rabkin, Angel M Mayor, Daniel B Klein, Michael A Horberg, Ronald J Bosch, Oghenowede Eyawo, Frank J Palella
BACKGROUND: There is persistent confusion as to whether abacavir (ABC) increases the risk for myocardial infarction (MI), and whether such risk differs by Type 1 (T1MI) or 2 (T2MI) MI in adults with HIV. METHODS: Incident MIs in NA-ACCORD participants were identified from 2001 to 2013. Discrete time marginal structural models addressed channeling biases and time-dependent confounding to estimate crude (HR) and adjusted hazard ratios (aHR) and 95% confidence intervals; analyses were performed for T1MI and T2MI separately...
February 6, 2018: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/29414686/kynurenic-acid-and-gpr35-regulate-adipose-tissue-energy-homeostasis-and-inflammation
#15
Leandro Z Agudelo, Duarte M S Ferreira, Igor Cervenka, Galyna Bryzgalova, Shamim Dadvar, Paulo R Jannig, Amanda T Pettersson-Klein, Tadepally Lakshmikanth, Elahu G Sustarsic, Margareta Porsmyr-Palmertz, Jorge C Correia, Manizheh Izadi, Vicente Martínez-Redondo, Per M Ueland, Øivind Midttun, Zachary Gerhart-Hines, Petter Brodin, Teresa Pereira, Per-Olof Berggren, Jorge L Ruas
The role of tryptophan-kynurenine metabolism in psychiatric disease is well established, but remains less explored in peripheral tissues. Exercise training activates kynurenine biotransformation in skeletal muscle, which protects from neuroinflammation and leads to peripheral kynurenic acid accumulation. Here we show that kynurenic acid increases energy utilization by activating G protein-coupled receptor Gpr35, which stimulates lipid metabolism, thermogenic, and anti-inflammatory gene expression in adipose tissue...
February 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29406747/cryo-ir-spectroscopy-of-n2-and-h2-on-ru8-the-effect-of-n2-on-the-h-migration
#16
Sebastian Dillinger, Matthias P Klein, Annika Steiner, David C McDonald, Michael A Duncan, Manfred M Kappes, Gereon Niedner-Schatteburg
We present the cryo IR-PD spectra of the coadsorbed [Ru8(H2)1(N2)4]+ and [Ru8(N2)4(H2)1]+ species differing in the adsorption sequence of H2 and N2, which we record via application of tandem cryo ion trapping. We observe strong evidence for dissociative H2 adsorption and the spectra reveal differences in the Ru-H stretching region, which we assign to distal and proximal hydrogen atom locations on the Ru8+ cluster, their migration likely hindered by preloaded nitrogen molecules, and unaffected by subsequent N2 adsorption...
February 6, 2018: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/29404672/meta-genome-wide-association-studies-identify-a-locus-on-chromosome-1-and-multiple-variants-in-the-mhc-region-for-serum-c-peptide-in-type-1-diabetes
#17
Delnaz Roshandel, Rose Gubitosi-Klug, Shelley B Bull, Angelo J Canty, Marcus G Pezzolesi, George L King, Hillary A Keenan, Janet K Snell-Bergeon, David M Maahs, Ronald Klein, Barbara E K Klein, Trevor J Orchard, Tina Costacou, Michael N Weedon, Richard A Oram, Andrew D Paterson
AIMS/HYPOTHESIS: The aim of this study was to identify genetic variants associated with beta cell function in type 1 diabetes, as measured by serum C-peptide levels, through meta-genome-wide association studies (meta-GWAS). METHODS: We performed a meta-GWAS to combine the results from five studies in type 1 diabetes with cross-sectionally measured stimulated, fasting or random C-peptide levels, including 3479 European participants. The p values across studies were combined, taking into account sample size and direction of effect...
February 5, 2018: Diabetologia
https://www.readbyqxmd.com/read/29402521/methotrexate-dose-in-patients-with-early-rheumatoid-arthritis-impacts-methotrexate-polyglutamate-pharmacokinetics-adalimumab-pharmacokinetics-and-efficacy-pharmacokinetic-and-exposure-response-analysis-of-the-concerto-trial
#18
Sandra L Goss, Cheri E Klein, Ziyi Jin, Charles S Locke, Ramona C Rodila, Hartmut Kupper, Gerd-Rudiger Burmester, Walid M Awni
PURPOSE: Methotrexate (MTX) and adalimumab are well-recognized treatments of rheumatoid arthritis (RA), the efficacy of which may be driven by intracellular polyglutamates (PGs). The aim of this analysis was to characterize MTX PG concentrations and adalimumab pharmacokinetics in the CONCERTO trial. In addition, the relationships between MTX dose/pharmacokinetics, adalimumab pharmacokinetics, and efficacy were evaluated. METHODS: CONCERTO was a double-blind, parallel-arm study in patients with early RA randomized to adalimumab 40 mg SC every other week plus blinded MTX 2...
February 2, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29394323/pymzml-v2-0-introducing-a-highly-compressed-and-seekable-gzip-format
#19
M Kösters, J Leufken, S Schulze, K Sugimoto, J Klein, R P Zahedi, M Hippler, S A Leidel, C Fufezan
Motivation: In the new release of pymzML (v2.0), we have optimized the speed of this established tool for mass spectrometry data analysis to adapt to an increasing amounts of data in mass spectrometry. Thus, we integrated faster libraries for numerical calculations, improved data retrieving algorithms and have optimized the source code. Importantly, to adapt to rapidly growing file sizes, we developed a generalizable compression scheme for very fast random access and applied this concept to mzML files to retrieve spectral data...
January 31, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29393744/lack-of-effectiveness-of-tramadol-hydrochloride-for-the-treatment-of-pain-and-joint-dysfunction-in-dogs-with-chronic-osteoarthritis
#20
Steven C Budsberg, Bryan T Torres, Stephanie A Kleine, Gabriella S Sandberg, Amanda K Berjeski
OBJECTIVE To investigate the effectiveness of tramadol for treatment of osteoarthritis in dogs. DESIGN Randomized, blinded, placebo-controlled crossover study. ANIMALS 40 dogs with clinical osteoarthritis of the elbow or stifle joint. PROCEDURES Dogs orally received 3 times/d (morning, midday, and night) for a 10-day period each of 3 identically appearing treatments (placebo; carprofen at 2.2 mg/kg [1 mg/lb], q 12 h [morning and night], with placebo at midday; or tramadol hydrochloride at 5 mg/kg [2.3 mg/lb], q 8 h) in random order, with treatment sessions separated by a minimum 7-day washout period...
February 15, 2018: Journal of the American Veterinary Medical Association
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