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https://www.readbyqxmd.com/read/28487255/disruption-of-adolescents-circadian-clock-the-vicious-circle-of-media-use-exposure-to-light-at-night-sleep-loss-and-risk-behaviors
#1
Yvan Touitou, David Touitou, Alain Reinberg
Although sleep is a key element in adolescent development, teens are spending increasing amounts of time online with health risks related to excessive use of electronic media (computers, smartphones, tablets, consoles…) negatively associated with daytime functioning and sleep outcomes. Adolescent sleep becomes irregular, shortened and delayed in relation with later sleep onset and early waking time due to early school starting times on weekdays which results in rhythm desynchronization and sleep loss. In addition, exposure of adolescents to the numerous electronic devices prior to bedtime has become a great concern because LEDs emit much more blue light than white incandescent bulbs and compact fluorescent bulbs and have therefore a greater impact on the biological clock...
May 6, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28443630/accelerating-recovery-from-jet-lag-prediction-from-a-multi-oscillator-model-and-its-experimental-confirmation-in-model-animals
#2
Hiroshi Kori, Yoshiaki Yamaguchi, Hitoshi Okamura
The endogenous circadian clock drives oscillations that are completely synchronized with the environmental day-night rhythms with a period of approximately 24 hours. Temporal misalignment between one's internal circadian clock and the external solar time often occurs in shift workers and long-distance travelers; such misalignments are accompanied by sleep disturbances and gastrointestinal distress. Repeated exposure to jet lag and rotating shift work increases the risk of lifestyle-related diseases, such as cardiovascular complaints and metabolic insufficiencies...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427145/uncoupling-genotoxic-stress-responses-from-circadian-control-increases-susceptibility-to-mammary-carcinogenesis
#3
Mingzhu Fang, Pamela A Ohman Strickland, Hwan-Goo Kang, Helmut Zarbl
We previously demonstrated that chemopreventive methylselenocysteine (MSC) prevents N-Nitroso-N-methylurea (NMU)-induced mammary carcinogenesis in the susceptible Fischer 344 (F344) rats by enhancing NAD+-dependent SIRT1 activity, restoring circadian expression of Period 2 (Per2) and circadian controlled genes. Here, we show that compared to the genetically resistant Copenhagen (COP) rat strain, mammary glands of the F344 rats have a 4-hour phase delay in circadian expression of Per2. Consequently, F344 rats failed to increase SIRT1 activity and circadian expression of Per2 and DDRR genes after exposure to NMU...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28416429/-life-threatening-sleepwalking-elpenor-s-syndrome-in-a-10-year-old-child
#4
M-A Madigand-Tordjman, P-J Egler, F Bertran, M Jokic, F Guénolé
Though benign in the majority of cases, sleepwalking sometimes causes injuries due, among other causes, to falls. Such accidents can be life-threatening - a situation that has been termed Elpenor syndrome (in reference to an accident experienced by a character in Homer's epic The Odyssey) - in particular when entailing defenestration. This syndrome has been described in adults and adolescents; we report here a case in a child. OBSERVATION: This 10-year-old girl was admitted at night to our hospital after a 3-m fall at home...
April 14, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28415855/predicting-jet-lag-in-long-haul-cabin-crew-the-role-of-illness-cognitions-and-behaviour
#5
Cristina Ruscitto, Jane Ogden
OBJECTIVE: Established risk factors for jet lag are mostly physiological including circadian preference, age, gender, the number of flight zones crossed and to some extent direction of travel. Some research has also highlighted a role for psychosocial factors including sleep, diet and 'circadian' health behaviours and illness cognitions although this remains relatively untested. The aim of this study was to evaluate the role of sleep, diet and illness cognitions in predicting perceived jet lag amongst long-haul crew...
April 18, 2017: Psychology & Health
https://www.readbyqxmd.com/read/28411937/preparing-for-international-travel-and-global-medical-care
#6
REVIEW
Swaminatha V Mahadevan, Matthew C Strehlow
Thorough pretravel preparation and medical consultation can mitigate avoidable health and safety risks. A comprehensive pretravel medical consultation should include an individualized risk assessment, immunization review, and discussion of arthropod protective measures, malaria prophylaxis, traveler's diarrhea, and injury prevention. Travel with children and jet lag reduction require additional planning and prevention strategies; travel and evacuation insurance may prove essential when traveling to less resourced countries...
May 2017: Emergency Medicine Clinics of North America
https://www.readbyqxmd.com/read/28401936/bmal1-links-the-circadian-clock-to-viral-airway-pathology-and-asthma-phenotypes
#7
A Ehlers, W Xie, E Agapov, S Brown, D Steinberg, R Tidwell, G Sajol, R Schutz, R Weaver, H Yu, M Castro, L B Bacharier, X Wang, M J Holtzman, J A Haspel
Patients with asthma experience circadian variations in their symptoms. However it remains unclear how specific aspects of this common airway disease relate to clock genes, which are critical to the generation of circadian rhythms in mammals. Here, we used a viral model of acute and chronic airway disease to examine how circadian clock disruption affects asthmatic lung phenotypes. Deletion of the core clock gene bmal1 or environmental disruption of circadian function by jet lag exacerbated acute viral bronchiolitis caused by Sendai virus (SeV) and influenza A virus in mice...
April 12, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28363442/transatlantic-flight-not-only-jet-lag
#8
Offir Paz, Nicolay Teodorovich, Yonatan Kogan, Moshe Swissa
No abstract text is available yet for this article.
March 28, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28358954/modulation-of-circadian-rhythms-affects-corneal-epithelium-renewal-and-repair-in-mice
#9
Yunxia Xue, Peng Liu, Hanqing Wang, Chengju Xiao, Cuipei Lin, Jun Liu, Dong Dong, Ting Fu, Yabing Yang, Zhaorui Wang, Hongwei Pan, Jiansu Chen, Yangqiu Li, Dongqing Cai, Zhijie Li
Purpose: In mammalian corneal epithelium, mitosis shows a distinct circadian pattern. However, how this circadian pattern is maintained, and how it or its disruption influence renewal and regeneration remain unclear. Methods: C57BL/6 mice were maintained under 12-hour light/12-hour dark (LD), 12-hour light/12-hour light (LL), 12-hour dark/12-hour dark (DD), or reversed LD (DL, 12-hour dark/12-hour light; jet-lag defined as a shift of 12 hours) conditions. Mitotic cells in corneal epithelium were enumerated and analyzed via immunofluorescence at different zeitgeber times (ZTs)...
March 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28345624/the-effects-of-self-selected-light-dark-cycles-and-social-constraints-on-human-sleep-and-circadian-timing-a-modeling-approach
#10
Anne C Skeldon, Andrew J K Phillips, Derk-Jan Dijk
Why do we go to sleep late and struggle to wake up on time? Historically, light-dark cycles were dictated by the solar day, but now humans can extend light exposure by switching on artificial lights. We use a mathematical model incorporating effects of light, circadian rhythmicity and sleep homeostasis to provide a quantitative theoretical framework to understand effects of modern patterns of light consumption on the human circadian system. The model shows that without artificial light humans wakeup at dawn...
March 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28318321/social-jet-lag-sleep-corrected-formula
#11
Konrad S Jankowski
Social jet lag is a term describing misalignment between social and biological times. In this article, it is argued that the currently used formula for social jet lag captures not only this misalignment, but also sleep debt resulting from sleep deprivation during workdays. It is proposed to adopt the sleep-corrected formula for social jet lag, which takes the form of the difference between the sleep onset on free days and workdays in the case of subjects with longer sleep and later (or equal) sleep onset on free days compared to workdays; it takes the form of the difference between the sleep offset on free days and workdays for subjects with longer sleep and earlier (or equal) sleep offset on workdays compared to free days...
2017: Chronobiology International
https://www.readbyqxmd.com/read/28224616/critical-cholangiocarcinogenesis-control-by-cryptochrome-clock-genes
#12
Ali Mteyrek, Elisabeth Filipski, Catherine Guettier, Malgorzata Oklejewicz, Gijsbertus T J van der Horst, Alper Okyar, Francis Lévi
A coordinated network of molecular circadian clocks in individual cells generates 24-hr rhythms in liver metabolism and proliferation. Circadian disruption through chronic jet lag or Per2 clock gene mutation was shown to accelerate hepatocarcinoma development in mice. As divergent effects were reported for clock genes Per and Cry regarding xenobiotic toxicity, we questioned the role of Cry1 and Cry2 in liver carcinogenesis. Male WT and Cry1(-/-) Cry2(-/-) mice (C57Bl/6 background) were chronically exposed to diethylnitrosamine (DEN) at ZT11...
June 1, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28178375/melatonin-restores-hippocampal-neural-precursor-cell-proliferation-and-prevents-cognitive-deficits-induced-by-jet-lag-simulation-in-adult-mice
#13
Deetje Iggena, York Winter, Barbara Steiner
Frequent flyers and shift workers undergo circadian dysrhythmia with adverse impact on body and mind. The circadian rhythm disorder "jet lag" disturbs hippocampal neurogenesis and spatial cognition, which represent morphological and functional adult brain plasticity. This raises the question if pro-neurogenic stimuli might prevent those consequences. However, suitable measures to mitigate jet lag-induced adverse effects on brain plasticity have been neglected so far. Here, we used adult C57Bl6 mice to investigate the pro-neurogenic stimuli melatonin (8 mg/kg i...
February 8, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28152057/potent-effects-of-flavonoid-nobiletin-on-amplitude-period-and-phase-of-the-circadian-clock-rhythm-in-per2-luciferase-mouse-embryonic-fibroblasts
#14
Ayako Shinozaki, Kenichiro Misawa, Yuko Ikeda, Atsushi Haraguchi, Mayo Kamagata, Yu Tahara, Shigenobu Shibata
Flavonoids are natural polyphenols that are widely found in plants. The effects of flavonoids on obesity and numerous diseases such as cancer, diabetes, and Alzheimer's have been well studied. However, little is known about the relationships between flavonoids and the circadian clock. In this study, we show that continuous or transient application of flavonoids to the culture medium of embryonic fibroblasts from PER2::LUCIFERASE (PER2::LUC) mice induced various modifications in the circadian clock amplitude, period, and phase...
2017: PloS One
https://www.readbyqxmd.com/read/28115724/how-jet-lag-impairs-major-league-baseball-performance
#15
Alex Song, Thomas Severini, Ravi Allada
Laboratory studies have demonstrated that circadian clocks align physiology and behavior to 24-h environmental cycles. Examination of athletic performance has been used to discern the functions of these clocks in humans outside of controlled settings. Here, we examined the effects of jet lag, that is, travel that shifts the alignment of 24-h environmental cycles relative to the endogenous circadian clock, on specific performance metrics in Major League Baseball. Accounting for potential differences in home and away performance, travel direction, and team confounding variables, we observed that jet-lag effects were largely evident after eastward travel with very limited effects after westward travel, consistent with the >24-h period length of the human circadian clock...
February 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28109712/effects-of-long-haul-transmeridian-travel-on-player-preparedness-case-study-of-a-national-team-at-the-2014-fifa-world-cup
#16
Peter M Fowler, Alan McCall, Mark Jones, Rob Duffield
OBJECTIVES: Describe the effects of eastward long-haul transmeridian air travel on subjective jet-lag, sleep and wellness in professional football (soccer) players prior to the 2014 FIFA World Cup in Brazil. DESIGN: Single cohort involving twenty-two male professional football players representing a national football team. METHODS: Data was collected from players prior to and following international travel from Sydney, Australia to Vitoria, Brazil...
April 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28052921/the-circadian-oscillator-of-the-cerebral-cortex-molecular-biochemical-and-behavioral-effects-of-deleting-the-arntl-clock-gene-in-cortical-neurons
#17
Tenna Bering, Mikkel Bloss Carstensen, Gitta Wörtwein, Pia Weikop, Martin Fredensborg Rath
A molecular circadian oscillator resides in neurons of the cerebral cortex, but its role is unknown. Using the Cre-LoxP method, we have here abolished the core clock gene Arntl in those neurons. This mouse represents the first model carrying a deletion of a circadian clock component specifically in an extrahypothalamic cell type of the brain. Molecular analyses of clock gene expression in the cerebral cortex of the Arntl conditional knockout mouse revealed disrupted circadian expression profiles, whereas clock gene expression in the suprachiasmatic nucleus was still rhythmic, thus showing that Arntl is required for normal function of the cortical circadian oscillator...
January 3, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/27987529/melatonin-promotes-circadian-rhythm-induced-proliferation-through-clock-histone-deacetylase-3-c-myc-interaction-in-mouse-adipose-tissue
#18
Zhenjiang Liu, Lu Gan, Dan Luo, Chao Sun
Melatonin is synthesized in the pineal gland and controls circadian rhythm of peripheral adipose tissue, resulting in changes in body weight. Although core regulatory components of clock rhythmicity have been defined, insight into the mechanisms of circadian rhythm-mediated proliferation in adipose tissue is still limited. Here, we showed that melatonin (20 mg/kg/d) promoted circadian and proliferation processes in white adipose tissue. The circadian amplitudes of brain and muscle aryl hydrocarbon receptor nuclear translocator-like 1 (Bmal1, P<...
December 17, 2016: Journal of Pineal Research
https://www.readbyqxmd.com/read/27981356/chronomedicine-and-type-2-diabetes-shining-some-light-on-melatonin
#19
REVIEW
Andrew C Forrestel, Susanne U Miedlich, Michael Yurcheshen, Steven D Wittlin, Michael T Sellix
In mammals, the circadian timing system drives rhythms of physiology and behaviour, including the daily rhythms of feeding and activity. The timing system coordinates temporal variation in the biochemical landscape with changes in nutrient intake in order to optimise energy balance and maintain metabolic homeostasis. Circadian disruption (e.g. as a result of shift work or jet lag) can disturb this continuity and increase the risk of cardiometabolic disease. Obesity and metabolic disease can also disturb the timing and amplitude of the clock in multiple organ systems, further exacerbating disease progression...
December 16, 2016: Diabetologia
https://www.readbyqxmd.com/read/27940437/chronic-jet-lag-promotes-metabolic-dysfunction-and-hepatocarcinogenesis
#20
(no author information available yet)
Chronic circadian dysfunction disrupts liver gene expression and metabolism to promote NAFLD and cancer.
January 2017: Cancer Discovery
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