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jet lag

Neta Tuvia, Pontus B Persson, Anja B Persson
Have you ever felt socially jet lagged? Running out of time? Or that everyone around you just keeps running late? If the answer is yes, this might not only be your subjective feeling, but rather a measurable outcome in a society comprising young and old, owls and larks, and all of them with clocks running in different periods, phases and amplitudes. This article is protected by copyright. All rights reserved.
October 14, 2016: Acta Physiologica
Susan Kohl Malone, Babette Zemel, Charlene Compher, Margaret Souders, Jesse Chittams, Aleda Leis Thompson, Allan Pack, Terri H Lipman
The relationship between sleep duration and obesity in adolescents is inconclusive. This may stem from a more complex relationship between sleep and obesity than previously considered. Shifts toward evening preferences, later sleep-wake times and irregular sleep-wake patterns are typical during adolescence but their relationship to body mass index (BMI) has been relatively unexplored. This cross-sectional study examined associations between sleep duration, midpoint of sleep and social jet lag (estimated from 7 days of continuous actigraphy monitoring), and morningness/eveningness with BMIs (BMI z-scores) and waist-to-height ratios in 14-17-year-old adolescents...
August 11, 2016: Chronobiology International
Cristina Ruscitto, Jane Ogden
OBJECTIVE: Jet lag is common place amongst long-haul cabin crew. Timed food has been shown to reset the circadian rhythm in rodents. Implementation intentions have been used to change eating behaviour. Mealtimes could therefore be used as a countermeasure to reduce jet lag and improve alertness in long-haul cabin crew through forming an implementation intention to improve the regularity of meals on days off. DESIGN: Sixty long-haul crew took part in a randomised controlled trial, with two conditions: forming an implementation intention to eat regular meals on days off vs...
October 14, 2016: Psychology & Health
Alexandra Vaccaro, Serge Birman, André Klarsfeld
Endogenous circadian clocks with ~24-h periodicity are found in most organisms from cyanobacteria to humans. Daylight synchronizes these clocks to solar time. In humans, shift-work and jet lag perturb clock synchronization, and such perturbations, when repeated or chronic, are strongly suspected to be detrimental to healthspan. Here we investigated locomotor aging and longevity in Drosophila melanogaster with genetically or environmentally disrupted clocks. We compared two mutations in period (per, a gene essential for circadian rhythmicity in Drosophila), after introducing them in a common reference genetic background: the arrhythmic per(01), and per(T) which displays robust short 16-h rhythms...
September 14, 2016: Experimental Gerontology
Alexander Andreychenko, Morgan Magnin, Katsumi Inoue
Automated verification of living organism models allows us to gain previously unknown knowledge about underlying biological processes. In this paper we show how parametric time model checking can be applied to define the time behavior of biological oscillatory systems more precisely. In particular, we focus on the resilience properties of such systems. This notion was introduced to understand the behavior of biological systems (e.g. the mammalian circadian rhythm) that are reactive and adaptive enough to endorse major changes in their environment (e...
September 13, 2016: Bio Systems
Ariadna Amador, Salvador Huitron-Resendiz, Amanda J Roberts, Theodore M Kamenecka, Laura A Solt, Thomas P Burris
The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery that regulates the circadian clock. The identical core clock machinery regulates myriad endocrine and metabolic functions providing a link between sleep and metabolic health. The REV-ERBs (REV-ERBα and REV-ERBβ) are nuclear receptors that are key regulators of the molecular clock and have been successfully targeted using small molecule ligands...
2016: PloS One
Josiane L Broussard, Eve Van Cauter
PURPOSE OF REVIEW: The purpose of this review is to summarize recent developments linking disturbances of sleep and circadian rhythms to an increased risk for obesity, and to review novel research on potential countermeasures. RECENT FINDINGS: Effective treatments for obesity are limited, with long-term adherence to lifestyle changes proving difficult to maintain. Identifying new preventive strategies based on modifiable risk factors is therefore imperative in the fight against obesity...
October 2016: Current Opinion in Endocrinology, Diabetes, and Obesity
Amy C Reynolds, Jessica L Paterson, Sally A Ferguson, Dragana Stanley, Kenneth P Wright, Drew Dawson
Prevalence and impact of metabolic disease is rising. In particular, overweight and obesity are at epidemic levels and are a leading health concern in the Western world. Shift work increases the risk of overweight and obesity, along with a number of additional metabolic diseases, including metabolic syndrome and type 2 diabetes (T2D). How shift work contributes to metabolic disease has not been fully elucidated. Short sleep duration is associated with metabolic disease and shift workers typically have shorter sleep durations...
July 11, 2016: Sleep Medicine Reviews
Lionel H Opie, Sandrine Lecour
Melatonin, widely used to counter transatlantic travel jet lag and insomnia, is synthesized in the suprachiasmatic nucleus of the anterior pituitary gland. Its release into the circulation is stimulated by the onset of darkness, followed by a progressive decrease in blood levels with the onset of dawn. Melatonin administration can maintain the quality of sleep and help to counteract age-induced cognitive decline. Melatonin can also limit the severity of a variety of cardiovascular and cerebrovascular diseases, diabetes, and cancer...
October 2016: European Heart Journal. Cardiovascular Pharmacotherapy
David P Martin, Nicolas L Melby, Shinita M Jordan, Anthony J Bednar, Alan J Kennedy, Maria E Negrete, Mark A Chappell, Aimee R Poda
Engineered nanomaterials (ENMs) are being incorporated into a variety of consumer products due to unique properties that offer a variety of advantages over bulk materials. Understanding of the nano-specific risk associated with nano-enabled technologies, however, continues to lag behind research and development, registration with regulators, and commercialization. One example of a nano-enabled technology is nanosilver ink, which can be used in commercial ink-jet printers for the development of low-cost printable electronics...
November 2016: Chemosphere
Thales Papagiannakopoulos, Matthew R Bauer, Shawn M Davidson, Megan Heimann, Lakshmipriya Subbaraj, Arjun Bhutkar, Jordan Bartlebaugh, Matthew G Vander Heiden, Tyler Jacks
Circadian rhythms are 24-hr oscillations that control a variety of biological processes in living systems, including two hallmarks of cancer, cell division and metabolism. Circadian rhythm disruption by shift work is associated with greater risk for cancer development and poor prognosis, suggesting a putative tumor-suppressive role for circadian rhythm homeostasis. Using a genetically engineered mouse model of lung adenocarcinoma, we have characterized the effects of circadian rhythm disruption on lung tumorigenesis...
August 9, 2016: Cell Metabolism
Eric Caumes, Loïc Epelboin, Geraldine Guermonprez, France Leturcq, Peter Clarke
BACKGROUND: We currently lack a comprehensive and systematic description of the challenges and health impairments (HI) faced by Captain Haddock over the course of the 15 Tintin adventures in which he appears. Their respective HIs have yet to be compared. METHODS: We evaluated the spectrum of HIs that Haddock sustains in these 15 adventures as well as their causes, consequences, and their relationship to alcohol or travel beyond Belgium. We diagnosed Haddock's HIs according to descriptive terms in the text...
July 2016: La Presse Médicale
Tiffany Fleet, Erin Stashi, Bokai Zhu, Kimal Rajapakshe, Kathrina L Marcelo, Nicole M Kettner, Blythe K Gorman, Cristian Coarfa, Loning Fu, Bert W O'Malley, Brian York
Circadian rhythmicity is a fundamental process that synchronizes behavioral cues with metabolic homeostasis. Disruption of daily cycles due to jet lag or shift work results in severe physiological consequences including advanced aging, metabolic syndrome, and even cancer. Our understanding of the molecular clock, which is regulated by intricate positive feedforward and negative feedback loops, has expanded to include an important metabolic transcriptional coregulator, Steroid Receptor Coactivator-2 (SRC-2), that regulates both the central clock of the suprachiasmatic nucleus (SCN) and peripheral clocks including the liver...
October 2016: Journal of Biological Rhythms
Audrey Jansen van Rensburg, Dina C Janse Van Rensburg, Catharina C Grant
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Ritsuko Matsumura, Koichi Node, Makoto Akashi
Almost all living organisms, including humans, exhibit diurnal rhythms of physiology and behavior, which are driven by the circadian clock. Many studies have found that chronic misalignment between circadian and environmental/social rhythms carries a significant risk of various disorders, including sleep disorders, metabolic syndrome, cardiovascular diseases and cancer. However, irregular sleep-wake cycles and circadian maladjustment often cause 'social jet lag', which is minor but chronic jet-lag in our daily lives...
September 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
William J Kraemer, David R Hooper, Brian R Kupchak, Catherine Saenz, Lee E Brown, Jakob L Vingren, Hui Ying Luk, William H DuPont, Tunde K Szivak, Shawn D Flanagan, Lydia K Caldwell, Daniela Eklund, Elaine C Lee, Keijo Häkkinen, Jeff S Volek, Steven J Fleck, Carl M Maresh
The purpose was to examine the effects of a round trip trans-American jet travel on performance, hormonal alterations, and recovery. Ten matched pairs of recreationally trained men were randomized to either a compression group (COMP) (n = 10; age: 23.1 ± 2.4 yr; height: 174.8 ± 5.3 cm; body mass: 84.9 ± 10.16 kg; body fat: 15.3 ± 6.0%) or control group (CONT) (n = 9; age: 23.2 ± 2.3 yr; height: 177.5 ± 6.3 cm; weight: 84.3 ± 8.99 kg; body fat: 15.1 ± 6.4%). Subjects flew directly from Hartford, CT to Los Angeles, CA 1 day before a simulated sport competition (SSC) designed to create muscle damage and returned the next morning on an overnight flight back home...
August 1, 2016: Journal of Applied Physiology
Samantha Noyek, Kathleen Yaremchuk, Brian Rotenberg
No abstract text is available yet for this article.
August 2016: Laryngoscope
Logan Roberts, Tanya L Leise, David K Welsh, Todd C Holmes
Light is the primary signal that calibrates circadian neural circuits and thus coordinates daily physiological and behavioral rhythms with solar entrainment cues. Drosophila and mammalian circadian circuits consist of diverse populations of cellular oscillators that exhibit a wide range of dynamic light responses, periods, phases, and degrees of synchrony. How heterogeneous circadian circuits can generate robust physiological rhythms while remaining flexible enough to respond to synchronizing stimuli has long remained enigmatic...
August 2016: Journal of Biological Rhythms
Leandro P Casiraghi, Ana Alzamendi, Andrés Giovambattista, Juan J Chiesa, Diego A Golombek
Metabolic functions are synchronized by the circadian clock setting daily patterns of food intake, nutrient delivery, and behavioral activity. Here, we study the impact of chronic jet-lag (CJL) on metabolism, and test manipulations aimed to overcome potential alterations. We recorded weight gain in C57Bl/6 mice under chronic 6 h advances or delays of the light-dark cycle every 2 days (ChrA and ChrD, respectively). We have previously reported ChrA, but not ChrD, to induce forced desynchronization of locomotor activity rhythms in mice (Casiraghi et al...
April 2016: Physiological Reports
Frederik N Buijs, Luis León-Mercado, Mara Guzmán-Ruiz, Natali N Guerrero-Vargas, Francisco Romo-Nava, Ruud M Buijs
Circadian rhythms are generated by the autonomous circadian clock, the suprachiasmatic nucleus (SCN), and clock genes that are present in all tissues. The SCN times these peripheral clocks, as well as behavioral and physiological processes. Recent studies show that frequent violations of conditions set by our biological clock, such as shift work, jet lag, sleep deprivation, or simply eating at the wrong time of the day, may have deleterious effects on health. This infringement, also known as circadian desynchronization, is associated with chronic diseases like diabetes, hypertension, cancer, and psychiatric disorders...
May 2016: Physiology
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