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Svetlana Villevalde, Zhanna Kovbalava
OBJECTIVE: Microalbuminuria (MAU) and glomerular filtration rate (GFR) are the signs of subclinical kidney damage, independently predict cardiovascular morbidity and mortality. The aim of the study was to investigate the relative role of MAU, cardiac and vascular ultrasonography, carotid-femoral pulse wave velocity (PWV) for the detection of hypertensive target organ damage (TOD) and risk stratification. DESIGN AND METHOD: In 576 non-diabetic hypertensive patients without established cardiovascular or renal disease (291 male, 53...
September 2016: Journal of Hypertension
Yi Zhang, Yuyan Lu, Bin Bai, Shikai Yu, Jing Xiong, Dela Jia, Yawei Xu
OBJECTIVE: To compare of carotid-femoral pulse wave velocity (cf-PWV) and brachial-ankle PWV (ba-PWV) in the association with conventional cardiovascular risk factors and target organ damages (TODs). DESIGN AND METHOD: 1599 community-dwelling elderly subjects (age > 65 years old) in the northern Shanghai were recruited from June 2014 to August 2015. Cf-PWV and ba-PWV were measured by SphygmCor (AtCor, Australia) and VP1000 (Omron, Japan), respectively. Under the framework of comprehensive cardiovascular examinations, cardiovascular risk factors were assessed, and hypertensive TODs, including left ventricular mass index (LVMI), peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid intima-media thickness (CIMT), ankle-brachial index (ABI), creatinine clearance rate (CCR) and urinary albumin-creatinine ratio (UACR), were all evaluated...
September 2016: Journal of Hypertension
Jiadela Teliewubai, Yu-Yan Lv, Shi-Kai Yu, Bin Bai, Chen Chi, Kai Wang, Yi-Wu Zhou, Jing Xiong, Yi Zhang, Ya-Wei Xu
OBJECTIVE: The Eighth Joint National Committee Panel recommended novel blood pressure (BP) goals for individuals with hypertension, which is still under debate. We therefore assessed patients' target organ damages in controlled hypertensives defined by the Seventh or Eighth Joint National Committee thresholds (JNC7 and JNC8) in a community-based elderly Chinese population, in order to find the optimal BP goal for the elderly Chinese. DESIGN AND METHOD: 1599 community-based elderly participants (age > 65 years old) were recruited in the northern Shanghai...
September 2016: Journal of Hypertension
Zhendong Liu, Yingxin Zhao, Yuanli Dong, Biao Lu, Miaomiao Wei
OBJECTIVE: To explore the effects of Helicobacter pylori infection on atherosclerosis in patients with hypertension and type 2 diabetes mellitus (T2DM). DESIGN AND METHOD: 228 subjects (Mean age: 67.92 ± 7.51) were enrolled in this study. Whether or not did the patients infected with Hp by 14C-Urea Breath Test (14C-UBT). The participants were divided into infection-positive group and infection-negative group basing on the outcomes of 14C-UBT. Their Carotid-Radial pulse wave velocity(CrPWV) and Carotid intima media thickness(CIMT) were mornitored...
September 2016: Journal of Hypertension
Farag E Salama, Qasem A Anass, Abdelnaem A Abdelrahman, Elsayed B Saeed
Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD). The carotid intima-media thickness (CIMT) and arterial stiffness are useful markers of subclinical atherosclerosis and significantly correlate with various metabolic risk factors. Chemerin is one of the adipokines that may represent a link between obesity and inflammation and may be a potential candidate playing a role in the pathogenesis of atherosclerosis and cardiovascular complications. Therefore, we studied the relationship of chemerin levels with atherosclerosis as measured by CIMT in diabetic CKD patients, either predialysis or on hemodialysis (HD)...
September 2016: Saudi Journal of Kidney Diseases and Transplantation
Inderjeet Verma, Pawan Krishan, Ashit Syngle
OBJECTIVE: Accelerated atherosclerosis associated with an enhanced inflammatory state, which characterizes ankylosing spondylitis (AS), is the leading cause of increased cardiovascular risk. The objective of this study was to assess carotid intima-media thickness (CIMT) as a surrogate for subclinical atherosclerosis in AS patients and its possible correlation with disease-related clinical parameters. METHODS: We performed a prospective study of 30 consecutive patients meeting modified New York criteria for AS compared to 25 controls matched for age and sex...
December 2015: Rheumatol Ther
Amit Jain, Pankaj Tantia, Kailash Saini, A A Sulemani, P Sirohi, Puneet Rizwani, R P Agrawal
AIM: Diabetes is a well known risk factor for carotid atherosclerosis. However, screening of all diabetics by carotid ultrasonography is cumbersome and cost-effective. Search for anthropometric measures related to severity of disease has been relentless. It's a proposal for waist-calf ratio as a better marker of carotid atherosclerosis than traditional measurements as it is cost-effective and non-invasive. METHODS: This was a cross-sectional observational study...
March 2016: Journal of the Association of Physicians of India
Xin Guo, Dai Li, Min Chen, Lei Chen, Bikui Zhang, Tian Wu, Ren Guo
Recent studies have demonstrated functions of miR-145 in vascular smooth muscle cells (VSMCs) phenotypes and vascular diseases. In this study, we aim to determine whether CD40 is involved in miR-145 mediated switch of VSMC phenotypes. In cultured VSMCs, the effects of miR-145 and CD40 on TNF-α, TGF-β, and Homocysteine (Hcy) induced cell proliferation were evaluated by over-expression of miR-145 or by siRNA-mediated knockdown of CD40. We also used ultrasound imaging to explore the effect of miR-145 on carotid artery intima-media thickness (CIMT) in atherosclerotic cerebral infarction (ACI) patients...
October 12, 2016: Scientific Reports
Neeraj Garg, Mala Dharmalingam, Vinay Prabhu, N S Murthy
BACKGROUND: Polycystic ovary syndrome (PCOS) is a common endocrine problem, which is now recognized as not only a reproductive but also a metabolic disorder with long-term effects on women's health, it has a prevalence of 5-10% in India. Among PCOS, it has been reported to have a higher incidence of cardiovascular disorders. Epidemiological studies have demonstrated an association between an increase in the carotid intimo-medial wall thickness (CIMT) and cardiovascular dysfunction. The objective of this study was to compare the CIMT of PCOS with normal women...
September 2016: Indian Journal of Endocrinology and Metabolism
Pradeep Kumar, Kamlesh Gupta, Arvind Mishra, M L Patel, Ajay Kumar Verma
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Kemal Atasayan, Tevfik Yoldemir, Sedef Ramoglu, Dilek Gogas Yavuz
OBJECTIVE: To evaluate the endothelial function and structure in patients with hirsutism in reproductive age. STUDY DESIGN: The study was conducted on 69 consecutive women admitted with complaints of hirsutism and 63 voluntary healthy women, as controls. A total of 132 subjects who applied to the Gynecology and Infertility Outpatient Clinics were included. Participants with modified Ferriman Gallway (mFG) score over 8 were considered to be hirsute. The demographic, metabolic, hormonal characteristics, risk factors of cardiovascular disease, CIMT (carotis intima media thickness) and FMD (flow-mediated dilatation) were compared between hirsute women and those in the control group...
October 3, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Anamitra Barik, Ravi V Shah, Aferdita Spahillari, Venkatesh L Murthy, Bharath Ambale-Venkatesh, Rajesh Kumar Rai, Kaushik Das, Amal Santra, Jaba Ranjan Hembram, Dilip Bhattacharya, Jane E Freedman, Joao Lima, Ranendra Das, Pinakpani Bhattacharyya, Saumya Das, Abhijit Chowdhury
BACKGROUND/OBJECTIVES: While adiposity and hepatic steatosis are linked to cardiovascular risk in developed countries, their prevalence and impact in low-income countries are poorly understood. We investigated the association of anthropomorphic variables and hepatic steatosis with cardiometabolic risk profiles and subclinical cardiovascular disease (CVD) in a large rural Indian cohort. METHODS: In 4691 individuals in the Birbhum Population Project in West Bengal, India, we performed liver ultrasonography, carotid ultrasound and biochemical and clinical profiling...
September 30, 2016: International Journal of Cardiology
Ji Hyun Yoon, In-Jeong Cho, Hyuk-Jae Chang, Ji Min Sung, Jinyong Lee, Hojin Ryoo, Chi Young Shim, Geu-Ru Hong, Namsik Chung
BACKGROUND: Carotid intima media thickness (CIMT) and the presence of carotid plaque have been used for risk stratification of cardiovascular disease (CVD). To date, however, the association between multi-directional functional properties of carotid artery and CVD has not been fully elucidated. We sought to explore the multi-directional mechanics of the carotid artery in relation to cardiovascular risk. METHODS: Four hundred one patients who underwent carotid ultrasound were enrolled between January 2010 and April 2013...
September 2016: Journal of Cardiovascular Ultrasound
Barbara Pręgowska-Chwała, Aleksander Prejbisz, Marek Kabat, Bogna Puciłowska, Katarzyna Paschalis-Purtak, Elżbieta Florczak, Anna Klisiewicz, Beata Kuśmierczyk-Droszcz, Katarzyna Hanus, Michael Bursztyn, Andrzej Januszewicz
The purpose of the study was to evaluate the degree of morning blood pressure surge (MBPS) and its relationship with markers of cardiovascular alterations in untreated middle-aged hypertensives. We studied 241 patients (mean age, 36.6 ± 10.7 years). Subjects with higher sleep-through MBPS (st-MBPS) were older (P = .003), had higher carotid intima-media thickness (cIMT) (P = .05) and lower E/A ratio (P = .01) than those with lower MBPS. Subjects with higher prewakening MBPS (pw-MBPS) had significantly higher deceleration time (P = ...
October 2016: Journal of the American Society of Hypertension: JASH
Ping Luo, Lixia Wang, Haohui Zhu, Song Du, Guanggong Wang, Shoukun Ding
BACKGROUND: This study aimed to investigate the impact of atorvastatin (Ato) combined with ezetimibe (Eze) for the treatment of carotid atherosclerosis in patients with coronary heart disease (CHD). METHODS: One hundred and forty-eight CHD patients with carotid atherosclerosis were divided into the control (Ato alone) and combination (Ato and Eze) groups. The treatment course was 12 months; patient blood lipids, carotid intima-media thickness (CIMT), and carotid plaque area were measured before and after treatment...
September 2016: Acta Cardiol Sin
Jaana I Halonen, Hakim-Moulay Dehbi, Anna L Hansell, John Gulliver, Daniela Fecht, Marta Blangiardo, Frank J Kelly, Nish Chaturvedi, Mika Kivimäki, Cathryn Tonne
BACKGROUND: Road traffic noise has been linked to increased risk of stroke, for which hypertension and carotid intima-media thickness (cIMT) are risk factors. A link between traffic noise and hypertension has been established, but there are few studies on blood pressure and no studies on cIMT. OBJECTIVES: To examine cross-sectional associations for long-term exposure to night-time noise with cIMT, systolic blood pressure (SBP), diastolic blood pressure (DBP) and hypertension...
October 3, 2016: Environment International
Elif Azarsız, Neslihan Karaca, Erturk Levent, Necil Kutukculer, Eser Sozmen
BACKGROUND: Common variable immunodeficiency (CVID) is a rare clinically symptomatic primary immunodeficiency disorder which manifests a wide variability of symptoms, complications. Atherosclerosis in CVID patients have not been investigated yet contrary to other severe clinical complications. We aimed to investigate the chitotriosidase enzyme's role as an inflammation and atherosclerosis marker in pediatric CVID patients. METHODS: CVID patients (n =24) and healthy controls (n = 23) evaluated for chitotriosidase activity with other inflammation markers (hsCRP, myeloperoxidase, serum amyloid A, ferritin), lipid profile and echocardiographic findings (carotid artery intima media thickness - cIMT, brachial artery flow-mediated vazodilatation - FMD%)...
October 4, 2016: Annals of Clinical Biochemistry
Mohsen Mazidi, Peymane Vadadian, Peyman Rezaie, Mahmoud Reza Azarpazhooh, Habib Esmaeili, Majid Ghayour-Mobarhan, Andre Pascal Kengne, Gordon A Ferns
AIM: We aimed to investigate the relationship between carotid Intima Media Thickness (CIMT) and physical activity levels (PAL), in subjects with and without metabolic syndrome (MetS) and in indidiviuals with and without carotid artery plaque (CAP) defined using high-resolution ultrasound. METHOD: A sample of 506 subjects [215 (42.5%) males], aged 35-64 years was recruited from an urban population in Mashhad, Iran, using a stratified-cluster method as part of the Mashhad Stroke Heart Atherosclerosis Disorder (MASHAD) study cohort...
August 23, 2016: Diabetes & Metabolic Syndrome
Coskun U Oruc, Yunus E Akpinar, Shirkhan Amikishiyev, Ayse Kubat Uzum, Artur Salmaslioglu, Figen Gurdol, Beyhan Omer
OBJECTIVES: Recent research has shown that hypovitaminosis D may increase the risk of hypertension, vascular disease, diabetes mellitus, obesity and metabolic syndrome (MetS). Endothelial dysfunction (ED) is one of the key components of MetS which is associated with an imbalance between vasoactive substances such as nitric oxide (NO) and endothelins (ET). In this study, we assessed the association of 25(OH) D3 level with endothelial dysfunction and subclinical atherosclerosis in MetS patients...
October 2, 2016: Current Vascular Pharmacology
Lucio Parmeggiani, Michela Salandin, Flavio Egger, Fiorenzo Lupi, Marco Primerano, Giorgio Radetti
AIM: Migraine affects approximately 10-20% of the general population, including children and adolescents, and an association between migraine and increased risks for cardiovascular disease and stroke have been reported in adult patients. This study aimed to address the lack of data on children with migraine. METHODS: This study comprised 30 children and adolescents (16 male) with migraine. We evaluated their biochemical profile, glucose homeostasis, vascular function by flow mediated dilatation and arterial structure by carotid intima-media thickness (cIMT)...
September 30, 2016: Acta Paediatrica
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