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https://www.readbyqxmd.com/read/29137477/circulating-lipopolysaccharide-binding-protein-and-carotid-intima-media-thickness-in-obstructive-sleep-apnea
#1
I Trojova, M Kozarova, D Petrasova, Z Malachovska, I Paranicova, P Joppa, R Tkacova
Circulating lipopolysaccharide-binding protein (LBP), a metabolic endotoxemia marker, was identified as an independent predictor of atherosclerosis. Although increases in carotid intima-media thickness (CIMT) were repeatedly reported in obstructive sleep apnea (OSA), neither the role of OSA in metabolic endotoxemia nor of LBP in early atherosclerosis were explored in patients with OSA. At a tertiary university hospital we investigated the relationships between OSA, LBP and CIMT in 117 men who underwent full polysomnography and CIMT assessment by B-mode ultrasound...
November 10, 2017: Physiological Research
https://www.readbyqxmd.com/read/29135056/a-systematic-review-of-the-associations-between-hiv-hcv-coinfection-and-biomarkers-of-cardiovascular-disease
#2
REVIEW
Olatokunbo Osibogun, Oluseye Ogunmoroti, Erin D Michos, Erica S Spatz, Babatunde Olubajo, Khurram Nasir, Wasim Maziak
The incidence of human immunodeficiency virus (HIV) and hepatitis C virus (HCV) coinfection has been increasing with over 10 million people affected globally. The role biomarkers play as predictors of cardiovascular disease (CVD) risk among coinfected individuals is not well defined. We aimed to systematically review current evidence describing CVD biomarkers among individuals with HIV/HCV coinfection. We searched EMBASE, CINAHL, Google Scholar, PubMed, and Web of Science from inception to June 2017. MeSH terms and keywords were used to identify studies with information on HIV/HCV coinfection and CVD biomarkers (structural, functional, and serological) such as carotid intima-media thickness (CIMT), endothelial markers, C-reactive protein (CRP), homocysteine, and lipids...
November 14, 2017: Reviews in Medical Virology
https://www.readbyqxmd.com/read/29132970/at-home-and-in-group-delivery-of-constraint-induced-movement-therapy-in-children-with-hemiparesis-a-systematic-review
#3
REVIEW
Emilie Durand, Pascale Plante, Andrey-Anne Pelletier, Johanie Rondeau, Frédérique Simard, Julien Voisin
BACKGROUND: Constraint-induced movement therapy (CIMT) is increasingly recognized as an effective therapy for children with hemiparesis. However, the effectiveness of CIMT outside the standard rehabilitation protocol in clinical settings is less known. The aim of this systematic review was to investigate the effectiveness of CIMT conducted at home or in a group. METHODS: We searched CINAHL, PubMed and ScienceDirect in August 2017 to select articles of studies investigating the impact of CIMT performed at home and in a group on affected upper-limb ability, occupational performance, and quality of life of children...
November 10, 2017: Annals of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/29130404/differences-in-neural-pathways-are-related-to-the-short-or-long-term-benefits-of-constraint-induced-movement-therapy-in-patients-with-chronic-stroke-and-hemiparesis-a-pilot-cohort-study
#4
Takashi Takebayashi, Kohei Marumoto, Kayoko Takahashi, Kazuhisa Domen
Background No previous studies have determined how the post-stroke integrity of non-corticospinal neural pathways relates to the efficacy of constraint-induced movement therapy (CIMT). Objectives We aimed to clarify the relationship between several non-corticospinal neural pathway integrities and the short- and long-term benefits of CIMT. Methods This was a pilot cohort study (UMIN registration number: R00027136UMIN000023566), for which we enrolled 13 patients with chronic stroke and hemiparesis who had undergone CIMT...
November 13, 2017: Topics in Stroke Rehabilitation
https://www.readbyqxmd.com/read/29124969/the-gut-mycobiome-composition-is-linked-to-carotid-atherosclerosis
#5
M R Chacón, J Lozano-Bartolomé, M Portero-Otín, M M Rodríguez, G Xifra, J Puig, G Blasco, W Ricart, F J Chaves, J M Fernández-Real
The mycobiotic component of the microbiota comprises an integral, yet under-researched, part of the gastrointestinal tract. Here, we present a preliminary study of the possible contribution of gut mycobiota to sub-clinical atherosclerosis in a well-characterised group of obese and non-obese subjects in association with the Framingham Risk Score (FRS) and carotid intima-media thickness (cIMT). From all taxa identified, the relative abundance of the phylum Zygomycota, comprising the family Mucoraceae and genus Mucor, was negatively associated with cIMT and this association remained significant after controlling for false discovery rate...
November 10, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29123443/plasma-atherogenic-index-is-an-independent-indicator-of-subclinical-atherosclerosis-in-systemic-lupus-erythematosus
#6
Ali Ugur Uslu, Adem Kucuk, Abdullah Icli, Erkan Cure, Davut Sakiz, Sevket Arslan, Rabia Aydogan Baykara
Objective: Systemic lupus erythematosus (SLE) is characterized by chronic inflammation. Plasma atherogenic index (PAI) is a valuable marker for the cardiovascular disease and cardiac risk. The aim of this study was to evaluate the role and clinical use of PAI in atherosclerosis and the cardiac risk in SLE patients. Materials and Methods: We included 56 female SLE patients who were selected according to the American College of Rheumatology (1997) diagnosis criteria...
October 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/29110385/vitamin-d-and-progression-of-carotid-intima-media-thickness-in-hiv-positive-canadians
#7
H Huff, A T Merchant, E Lonn, E Pullenayegum, F Smaill, M Smieja
OBJECTIVES: Based on a growing body of evidence implicating low vitamin D status in the development of cardiovascular disease (CVD), we hypothesized that in Canadian HIV-positive adults, low 25-hydroxyvitamin D (25(OH)D) concentration would be associated with increased subclinical vascular disease progression. METHODS: We prospectively studied the relationship between baseline 25(OH)D and subsequent progression of carotid intima-media thickness (CIMT) between 2002 and 2011, in the Canadian HIV Vascular Study using stored blood specimens...
November 6, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29103864/apolipoprotein-e-gene-polymorphism-and-subclinical-carotid-atherosclerosis-the-northern-manhattan-study
#8
Brett Doliner, Chuanhui Dong, Susan H Blanton, Hannah Gardener, Mitchell S V Elkind, Ralph L Sacco, Ryan T Demmer, Moise Desvarieux, Tatjana Rundek
BACKGROUND: Apolipoprotein E (APOE) polymorphism has previously been associated with carotid intima-media thickness (cIMT) in predominantly Caucasian populations. We sought to test the strength of the relationship between APOE-ε4 carrier status and subclinical atherosclerosis in a tri-ethnic population with a large Hispanic representation. METHODS: We assessed the association between APOE polymorphism and cIMT and plaque burden among 1243 stroke-free individuals (mean age 69 years, 65% Hispanic, 18% black, 17% white) using a sequence of multivariable regression models...
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29102868/associations-of-adversity-in-childhood-and-risk-factors-for-cardiovascular-disease-in-mid-adulthood
#9
Emma L Anderson, Abigail Fraser, Rishi Caleyachetty, Rebecca Hardy, Debbie A Lawlor, Laura D Howe
Studies assessing associations of childhood psychosocial adversity (e.g. sexual abuse, physical neglect, parental death), as opposed to socioeconomic adversity, with cardiovascular disease (CVD) risk factors in adulthood are scarce. The aim of this study is to assess associations of various types of psychosocial adversity and cumulative adversity in childhood, with multiple CVD risk factors in mid-life. At study enrolment, women from the Avon Longitudinal Study of Parents and Children (N=3612) retrospectively reported: lack of maternal care, maternal overprotection, parental mental illness, household dysfunction, sexual abuse, physical and emotional abuse, and neglect in childhood...
November 2, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29096133/eslicarbazepine-acetate-and-carotid-intima-media-thickness-in-epileptic-patients
#10
Pedro Jesús Serrano-Castro, Javier Fernández-Pérez, Francisco Javier López-González, Manuel Toledo-Argany, José Carlos Estévez-María, Antonio Arjona-Padillo, Vicente Bertol-Alegre, José Angel Mauri-Llerda, Diego Tortosa-Conesa, Jesús Ruiz-Giménez, Rosa Querol-Pascual, Alberto García-Martínez, José Manuel Molto-Jorda, Manuel Payán-Ortiz, José Francisco Maestre-Moreno, José Galván-Espinosa
OBJECTIVE: Evaluate if eslicarbazepine acetate (ESL) in combination with other non-inducer antiepileptic drugs (AEDs) in the treatment of epilepsy may represent a positive impact in the cardiovascular risk profile. METHODS: multicentre, retrospective, observational, non-interventional, real-life study comparing patients treated with cytochrome P450 (CYP) inducer vs. ESL plus non-inducer AEDs. Primary endpoint: Carotid intima-media thickness (CIMT) measured following the Manheim Consensus criteria...
October 29, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29079990/the-effects-of-synbiotic-supplementation-on-carotid-intima-media-thickness-biomarkers-of-inflammation-and-oxidative-stress-in-people-with-overweight-diabetes-and-coronary-heart-disease-a-randomized-double-blind-placebo-controlled-trial
#11
Alireza Farrokhian, Fariba Raygan, Ali Soltani, Maryam Tajabadi-Ebrahimi, Mehran Sharifi Esfahani, Ali Akbar Karami, Zatollah Asemi
Synbiotics are known to exert multiple beneficial effects, including anti-inflammatory and antioxidant actions. The aim of this study was to evaluate the effects of synbiotic supplementation on carotid intima-media thickness (CIMT), biomarkers of inflammation, and oxidative stress in people with overweight, diabetes, and coronary heart disease (CHD). This randomized, double-blind, placebo-controlled trial was conducted and involved 60 people with overweight, diabetes, and CHD, aged 50-85 years old. Participants were randomly allocated into two groups to take either synbiotic supplements containing three probiotic bacteria spices Lactobacillus acidophilus strain T16 (IBRC-M10785), Lactobacillus casei strain T2 (IBRC-M10783), and Bifidobacterium bifidum strain T1 (IBRC-M10771) (2 × 10(9) CFU/g each) plus 800 mg inulin or placebo (n = 30 each group) for 12 weeks...
October 27, 2017: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/29064476/perirenal-fat-is-related-to-carotid-intima-media-thickness-in-children
#12
J Bassols, J-M Martínez-Calcerrada, A Prats-Puig, G Carreras-Badosa, S Xargay-Torrent, E Lizarraga-Mollinedo, M Feliu-Alsina, E Riera-Pérez, I Osiniri, F de Zegher, L Ibáñez, A López-Bermejo
BACKGROUND/OBJECTIVES: It is well known that increased abdominal fat is associated with cardiovascular (CV) risk. Perirenal fat has been recently associated with CV risk in adults. However, studies with children are lacking. We investigated the relationship of perirenal fat and other abdominal fat depots (including preperitoneal, intra-abdominal and subcutaneous fat) with carotid intima-media thickness (cIMT-a surrogate marker of CV risk) in prepubertal children, so as to identify novel markers that can be easily assessed and used in the early prevention of cardiovascular disease...
September 25, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29064046/hla-infections-and-inflammation-in-early-stages-of-atherosclerosis-in-children-with-type-1-diabetes
#13
Michal Odermarsky, Erkki Pesonen, Timo Sorsa, Åke Lernmark, Pirkko J Pussinen, Petru Liuba
AIMS: This prospective study focuses on risk factors for arterial damage in children with type 1 diabetes (T1D). METHODS: Eighty children and adolescents with T1D were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow-mediated dilatation (FMD) of the brachial artery, and plasma levels of matrix metalloproteinase (MMP)-8. All subjects were genotyped for HLA. The number of respiratory tract infections (RTI) during the past year was obtained by a questionnaire in 56 patients...
October 24, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/29063904/study-of-carotid-intimal-medial-thickness-in-essential-hypertension-with-or-without-left-ventricular-hypertrophy
#14
Himanshu Khutan, Simmi Aggarwal, K S Kajal, Ravinder Garg, Rupinderjeet Kaur, Amanpreet Kaur
INTRODUCTION: Hypertension and atherosclerosis though separate entities, are interrelated as hypertension plays an important role in the pathogenesis of atherosclerosis. This study was undertaken to study the association of carotid intimal medial thickness with left ventricular hypertrophy (LVH) in hypertensive patients. MATERIALS AND METHODS: Hundred hypertensives (JNC-7, Stage 1 and 2) between 30 and 55 years were enrolled in this prospective observational study conducted at a tertiary care teaching institute of Punjab, India...
October 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/29063462/the-role-of-microalbuminuria-as-a-predictor-of-subclinical-cardiovascular-events-in-rheumatoid-arthritis-patients-and-its-relation-to-disease-activity
#15
D W Nada, S El Morsy, M H Abu-Zaid, M A Aboelhawa, Mohammad A Zakaria, E A El Sheikh, R A Gaber
Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers...
October 23, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29050209/handgrip-strength-and-subclinical-carotid-atherosclerosis-in-relation-to-platelet-levels-among-hypertensive-elderly-japanese
#16
Yuji Shimizu, Shimpei Sato, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Koichiro Kadota, Shin-Ya Kawashiri, Keita Inoue, Yasuhiro Nagata, Takahiro Maeda
Age-related disruption of microvascular endothelium exacerbates hypertension and sarcopenia; and atherosclerosis is a well-known biological response to vascular endothelial injury. Therefore, prevalence of atherosclerosis among hypertensive elderly subjects may partly indicate the presence of an appropriate response to endothelial injury. We conducted a cross-sectional study of 795 elderly hypertensive Japanese subjects aged 60-89 years. Since platelet level is an indicator of vascular repair activity, subjects were stratified by platelet counts...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29043547/age-related-effects-of-bariatric-surgery-on-early-atherosclerosis-and-cardiovascular-risk-reduction
#17
Frederik H W Jonker, Vera A A van Houten, Leontine H Wijngaarden, René A Klaassen, André A E A de Smet, André Niezen, Lodewijk J D M Schelfhout, Tobias A Bruning, Erwin van der Harst
BACKGROUND: Carotid intima-media thickness (CIMT) is increasingly used as a prognostic indicator for early atherosclerosis and the development of cardiovascular disease. The objective of this study is to assess the exact effects of bariatric surgery on CIMT reduction in different age groups. METHODS: CIMT was measured just proximal to the bifurcation of the carotid artery in 166 patients with mean body mass index of 43.4 kg/m(2) before and at 6 and 12 months after bariatric surgery...
October 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29040868/identification-of-a-novel-proinsulin-associated-snp-and-demonstration-that-proinsulin-is-unlikely-to-be-a-causal-factor-in-subclinical-vascular-remodelling-using-mendelian-randomisation
#18
Rona J Strawbridge, Angela Silveira, Marcel den Hoed, Stefan Gustafsson, Jian'an Luan, Denis Rybin, Josée Dupuis, Ruifang Li-Gao, Maryam Kavousi, Abbas Dehghan, Kadri Haljas, Jari Lahti, Jesper R Gådin, Alexandra Bäcklund, Ulf de Faire, Karl Gertow, Phillipe Giral, Anuj Goel, Steve E Humphries, Sudhir Kurl, Claudia Langenberg, Lars L Lannfelt, Lars Lind, Cecilia C M Lindgren, Elmo Mannarino, Dennis O Mook-Kanamori, Andrew P Morris, Renée de Mutsert, Rainer Rauramaa, Peter Saliba-Gustafsson, Bengt Sennblad, Andries J Smit, Ann-Christine Syvänen, Elena Tremoli, Fabrizio Veglia, Björn Zethelius, Hanna M Björck, Johan G Eriksson, Albert Hofman, Oscar H Franco, Hugh Watkins, J Wouter Jukema, Jose C Florez, Nicholas J Wareham, James B Meigs, Erik Ingelsson, Damiano Baldassarre, Anders Hamsten
BACKGROUND AND AIMS: Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atherosclerosis and CVD are unclear. A genome-wide meta-analysis has identified nine loci associated with circulating proinsulin levels. Using proinsulin-associated SNPs, we set out to use a Mendelian randomisation approach to test the hypothesis that proinsulin plays a causal role in subclinical vascular remodelling...
November 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29032752/association-between-apolipoproteins-ai-and-b-and-ultrasound-indicators-of-carotid-atherosclerosis
#19
Zeljko Zivanovic, Ivana Divjak, Mirjana Jovicevic, Tamara Rabi-Zikic, Biljana Radovanovic, Svetlana Ruzicka-Kaloci, Djordje Stevan Popovic, Edita Stokic, Ksenija Gebauer-Bukurov, Katarina Zivanovic-Vujcic, Petar Slankamenac
BACKGROUND: Apolipoproteins A-I and B (apoA-I and apoB) may be better indicators of the risk of cardiovascular and cerebrovascular diseases than conventional risk factors (RFs). The onset of ischemic stroke (IS) may be preceded by the development of atherosclerotic changes in carotid arteries, which can be detected by ultrasound. Only a certain % of patients with IS have an (underlying) carotid etiology. OBJECTIVE: The aim of our study was to determine the association between ultrasound indicators of carotid atherosclerosis and the presence of apolipoproteins and other biomarkers in patients with IS...
October 10, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/29031563/gender-specific-association-of-desacylated-ghrelin-with-subclinical-atherosclerosis-in-the-metabolic-syndrome
#20
Michela Zanetti, Gianluca Gortan Cappellari, Annamaria Semolic, Ismet Burekovic, Maurizio Fonda, Luigi Cattin, Rocco Barazzoni
OBJECTIVE: Ghrelin, a gastric hormone with pleiotropic effects modulates vascular function and may influence atherosclerosis. Plasma ghrelin is reduced in the metabolic syndrome (MS), which is also characterized by early atherosclerosis. Ghrelin circulates in acylated (AG) and desacylated (DAG) forms. Their relative impact and that of gender on subclinical atherosclerosis in MS is unknown. AIM OF THE STUDY: To investigate potential associations of total, AG and DAG with carotid atherosclerosis and with gender in the MS...
October 11, 2017: Archives of Medical Research
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