Yingcheng Wu, Jiaqiang Ma, Xupeng Yang, Fang Nan, Tiancheng Zhang, Shuyi Ji, Dongning Rao, Hua Feng, Ke Gao, Xixi Gu, Shan Jiang, Guohe Song, Jiaomeng Pan, Mao Zhang, Yanan Xu, Shu Zhang, Yihui Fan, Xiaoying Wang, Jian Zhou, Li Yang, Jia Fan, Xiaoming Zhang, Qiang Gao
Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing functions across cancer types. However, given their short half-life, it remains challenging to explore how neutrophils adopt specific fates in cancer. Here, we generated and integrated single-cell neutrophil transcriptomes from 17 cancer types (225 samples from 143 patients). Neutrophils exhibited extraordinary complexity, with 10 distinct states including inflammation, angiogenesis, and antigen presentation. Notably, the antigen-presenting program was associated with favorable survival in most cancers and could be evoked by leucine metabolism and subsequent histone H3K27ac modification...
February 28, 2024: Cell