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https://www.readbyqxmd.com/read/28743159/chronic-hepatitis-c-virus-infection-and-neurocognitive-function-in-adult-survivors-of-childhood-cancer
#1
Adrienne Studaway, Rohit P Ojha, Tara M Brinkman, Nan Zhang, Malek Baassiri, Pia Banerjee, Matthew J Ehrhardt, Deokumar Srivastava, Leslie L Robison, Melissa M Hudson, Kevin R Krull
BACKGROUND: Cancer survivors transfused with blood products before reliable screening for hepatitis C virus (HCV) are at risk for infection. This study examined the impact of HCV on neurocognitive function and health-related quality of life (HRQOL) among adult survivors of childhood cancer. METHODS: Neurocognitive testing was conducted for 836 adult survivors of childhood cancer (mean age, 35 years [standard deviation, 7.4 years]; time since diagnosis, 29 years [standard deviation, 6...
July 25, 2017: Cancer
https://www.readbyqxmd.com/read/28742939/disparate-peroxisome-related-defects-in-arabidopsis-pex6-and-pex26-mutants-link-peroxisomal-retrotranslocation-and-oil-body-utilization
#2
Kim L Gonzalez, Wendell A Fleming, Yun-Ting Kao, Zachary J Wright, Savina V Venkova, Meredith J Ventura, Bonnie Bartel
Catabolism of fatty acids stored in oil bodies is essential for Arabidopsis seed germination and seedling development. This fatty acid breakdown occurs in peroxisomes, organelles that sequester oxidative reactions. Import of peroxisomal enzymes is facilitated by peroxins including PEX5, a receptor that delivers cargo proteins from the cytosol to the peroxisomal matrix. After cargo delivery, a complex of the PEX1 and PEX6 ATPases and the PEX26 tail-anchored membrane protein removes ubiquitinated PEX5 from the peroxisomal membrane...
July 25, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/28742937/models-for-discovery-of-targeted-therapy-in-genetic-epileptic-encephalopathies
#3
REVIEW
Snezana Maljevic, Christopher A Reid, Steven Petrou
Epileptic encephalopathies are severe disorders emerging in the first days to years of life that commonly include refractory seizures, various types of movement disorders, and different levels of developmental delay. In recent years, many de novo occurring variants have been identified in individuals with these devastating disorders. To unravel disease mechanisms the functional impact of detected variants associated with epileptic encephalopathies is investigated in a range of cellular and animal models. This review addresses efforts to advance and use such models to identify specific molecular and cellular targets for the development of novel therapies...
July 25, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28742808/self-help-guidebook-improved-quality-of-life-for-patients-with-irritable-bowel-syndrome
#4
Antonius Schneider, Stefanie Rosenberger, Johanna Bobardt, Jessica Bungartz-Catak, Oxana Atmann, Bernhard Haller, Anne Kennedy, Paul Enck
BACKGROUND: The primary aim of our study was to evaluate the impact of a comprehensive self-help guidebook on the disease related quality of life for patients with irritable bowel syndrome (IBS). The secondary aim was to evaluate whether the guidebook is less effective in IBS patients with depression, somatization disorder or panic disorder as a psychiatric comorbidity. METHODS: Prospective observational study. At baseline (t1), patients filled in the ´Functional Digestive Disorders Quality of Life´ (FDDQL) questionnaire and received the IBS guidebook together with an explanation of its content and use...
2017: PloS One
https://www.readbyqxmd.com/read/28742722/attention-deficit-hyperactivity-disorder-and-functional-defecation-disorders-in-children
#5
Sophie Kuizenga-Wessel, Ilan J N Koppen, Mana H Vriesman, Carlo Di Lorenzo, Marieke van Dijk, Maureen L R Beelen, Michael Groeneweg, Reino J Stoffelsen, Marc A Benninga
OBJECTIVES: To assess the prevalence of attention deficit hyperactivity disorder (ADHD) in children presenting with functional defecation disorders (FDDs) and to assess the prevalence of FDDs in children with ADHD. METHODS: A cross-sectional cohort study was carried out between September 2014 and May 2016. Group 1: Parents of children with FDDs according to the Rome III criteria completed the Child Behavior Checklist (CBCL) and the VvGK (Dutch questionnaire based on the American Disruptive Behavior Disorder rating scale)...
July 22, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28742606/functional-movement-screening-and-injury-rates-in-high-school-and-collegiate-runners-a-retrospective-analysis-of-3-prospective-observational-studies
#6
Benjamin V Bring, Miriam Chan, Robin C Devine, Christy L Collins, Jason Diehl, Benjamin Burkam
OBJECTIVE: Determine if the Functional Movement Screening (FMS) can be used to predict injury in high school and collegiate cross-country and track runners. DESIGN: Prospective Observational, Cohort Study, Level of Evidence, 2. SETTING: High schools and colleges in the Central Ohio area. PATIENTS: Inclusion: (1) cross-country or track runners at participating schools; (2) full participation without restrictions; and (3) signed informed assent or consent...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742602/is-there-a-relationship-between-the-functional-movement-screen-star-excursion-balance-test-and-balance-error-scoring-system
#7
Nicole D Harshbarger, Barton E Anderson, Kenneth C Lam
OBJECTIVE: To evaluate associations between the Functional Movement Screen (FMS), Star Excursion Balance Test (SEBT), and Balance Error Scoring System (BESS) scores. DESIGN: Correlational. SETTING: College athletic training facilities. PARTICIPANTS: Fifty-two intercollegiate athletes (men = 36 and women = 16) representing 8 sports and cleared for unrestricted sport participation. INTERVENTIONS: Participants completed the FMS, SEBT, and BESS, in random order, during 1 testing session...
July 21, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28742351/materials-screening-for-the-discovery-of-new-half-heuslers-machine-learning-versus-ab-initio-methods
#8
Fleur Legrain, Jesús Carrete, Ambroise van Roekeghem, Georg K H Madsen, Natalio Mingo
Machine learning (ML) is increasingly becoming a helpful tool in the search for novel functional compounds. Here we use classification via random forests to predict the stability of half-Heusler (HH) compounds, using only experimentally reported compounds as a training set. Cross-validation yields an excellent agreement between the fraction of compounds classified as stable and the actual fraction of truly stable compounds in the ICSD. The ML model is then employed to screen 71,178 different 1:1:1 compositions, yielding 481 likely stable candidates...
July 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28742330/computational-screening-of-bimetal-functionalized-zr6o8-mof-nodes-for-methane-c-h-bond-activation
#9
Dale R Pahls, Manuel A Ortuño, Peter H Winegar, Christopher J Cramer, Laura Gagliardi
Zr-based metal-organic frameworks (MOFs) are promising supports for copper-based catalysts able to activate methane. Homo- and heterobimetal-functionalized NU-1000 MOF nodes were selected to computationally screen the effect of ancillary metals for C-H bond activation, allowing us to correlate activation free energies with chemical descriptors.
July 25, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28742219/model-free-scoring-system-for-risk-prediction-with-application-to-hepatocellular-carcinoma-study
#10
Weining Shen, Jing Ning, Ying Yuan, Anna S Lok, Ziding Feng
There is an increasing need to construct a risk-prediction scoring system for survival data and identify important risk factors (e.g., biomarkers) for patient screening and treatment recommendation. However, most existing methodologies either rely on strong model assumptions (e.g., proportional hazards) or only handle binary outcomes. In this article, we propose a flexible method that simultaneously selects important risk factors and identifies the optimal linear combination of risk factors by maximizing a pseudo-likelihood function based on the time-dependent area under the receiver operating characteristic curve...
July 25, 2017: Biometrics
https://www.readbyqxmd.com/read/28742144/genome-wide-and-protein-kinase-focused-rnai-screens-reveal-conserved-and-novel-damage-response-pathways-in-trypanosoma-brucei
#11
Jennifer A Stortz, Tiago D Serafim, Sam Alsford, Jonathan Wilkes, Fernando Fernandez-Cortes, Graham Hamilton, Emma Briggs, Leandro Lemgruber, David Horn, Jeremy C Mottram, Richard McCulloch
All cells are subject to structural damage that must be addressed for continued growth. A wide range of damage affects the genome, meaning multiple pathways have evolved to repair or bypass the resulting DNA lesions. Though many repair pathways are conserved, their presence or function can reflect the life style of individual organisms. To identify genome maintenance pathways in a divergent eukaryote and important parasite, Trypanosoma brucei, we performed RNAi screens to identify genes important for survival following exposure to the alkylating agent methyl methanesulphonate...
July 24, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28741490/in-vivo-rnai-screening-for-pancreatic-cancer-drivers-piloting-the-wdr5-myc-axis
#12
Günter Schneider, Dieter Saur
Pancreatic ductal adenocarcinoma (PDAC) represents a major global health problem that causes over 200000 deaths each year worldwide. The disease is highly resistant to cytotoxic and targeted therapies and the average survival is less than 12 months. This situation prompted Alessandro Carugo and Giulio Draetta to develop a novel genetic mouse system, termed Patient-Based In Vivo Lethality to Optimize Treatment (PILOT), to perform functional RNAi-based in vivo screens to uncover and target PDAC drivers. In a forward genetic screen focused on epigenetic modifiers, a WDR5-Myc axis that regulates the DNA replication checkpoint was identified and exploited in vivo for therapeutic intervention...
August 2016: Trends in Cancer
https://www.readbyqxmd.com/read/28741265/mechanisms-of-type-2-diabetes-risk-loci
#13
REVIEW
Kyle J Gaulton
PURPOSE OF REVIEW: Deciphering the mechanisms of type 2 diabetes (T2DM) risk loci can greatly inform on disease pathology. This review discusses current knowledge of mechanisms through which genetic variants influence T2DM risk and considerations for future studies. RECENT FINDINGS: Over 100 T2DM risk loci to date have been identified. Candidate causal variants at risk loci map predominantly to non-coding sequence. Physiological, epigenomic and gene expression data suggest that variants at many known T2DM risk loci affect pancreatic islet regulation, although variants at other loci also affect protein function and regulatory processes in adipose, pre-adipose, liver, skeletal muscle and brain...
September 2017: Current Diabetes Reports
https://www.readbyqxmd.com/read/28740934/patient-reported-distress-and-survival-among-patients-receiving-definitive-radiation-therapy
#14
Yacob Habboush, Robert P Shannon, Shehzad K Niazi, Laeticia Hollant, Megan Single, Katherine Gaines, Bridget Smart, Nicolette T Chimato, Michael G Heckman, Steven J Buskirk, Laura A Vallow, Katherine S Tzou, Stephen J Ko, Jennifer L Peterson, Heather A Biers, Atiya B Day, Kimberly A Nelson, Jeff A Sloan, Michele Y Halyard, Robert C Miller
OBJECTIVE: Patient-reported distress (PRD) has not been well assessed in association with survival after radiation therapy (RT). The aims of this study were to evaluate the association between PRD level and survival after definitive RT and to identify the main causes of distress in definitive RT patients. METHODS AND MATERIALS: A total of 678 consecutive patients receiving definitive RT at our institution from April 2012 through May 2015 were included. All patients answered a PRD questionnaire that contained 30 items related to possible causes of distress, which could be rated from 1 (no distress) to 5 (high distress)...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28740826/epicog-sch-a-brief-battery-to-screen-cognitive-impact-of-schizophrenia-in-stable-outpatients
#15
Silvia Zaragoza Domingo, Julio Bobes, Maria-Paz García-Portilla, Claudia Morralla
Brief batteries in schizophrenia, are needed to screen for the cognitive impact of schizophrenia. We aimed to validate and co-norm the Epidemiological Study of Cognitive Impairment in Schizophrenia (EPICOG-SCH) derived brief cognitive battery. A cross-sectional outpatient evaluation was conducted of six-hundred-seventy-two patients recruited from 234 centers. The brief battery included well-known subtests available worldwide that cover cognitive domains related to functional outcomes: WAIS-III-Letter-Number-Sequencing-LNS, Category Fluency Test-CFT, Logical-Memory Immediate Recall-LM, and Digit-Symbol-Coding-DSC...
June 2017: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/28740608/gne-886-a-potent-and-selective-inhibitor-of-the-cat-eye-syndrome-chromosome-region-candidate-2-bromodomain-cecr2
#16
Terry D Crawford, James E Audia, Steve Bellon, Daniel J Burdick, Archana Bommi-Reddy, Alexandre Côté, Richard T Cummings, Martin Duplessis, E Megan Flynn, Michael Hewitt, Hon-Ren Huang, Hariharan Jayaram, Ying Jiang, Shivangi Joshi, James R Kiefer, Jeremy Murray, Christopher G Nasveschuk, Arianne Neiss, Eneida Pardo, F Anthony Romero, Peter Sandy, Robert J Sims, Yong Tang, Alexander M Taylor, Vickie Tsui, Jian Wang, Shumei Wang, Yongyun Wang, Zhaowu Xu, Laura Zawadzke, Xiaoqin Zhu, Brian K Albrecht, Steven R Magnuson, Andrea G Cochran
The biological function of bromodomains, epigenetic readers of acetylated lysine residues, remains largely unknown. Herein we report our efforts to discover a potent and selective inhibitor of the bromodomain of cat eye syndrome chromosome region candidate 2 (CECR2). Screening of our internal medicinal chemistry collection led to the identification of a pyrrolopyridone chemical lead, and subsequent structure-based drug design led to a potent and selective CECR2 bromodomain inhibitor (GNE-886) suitable for use as an in vitro tool compound...
July 13, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28739740/global-analysis-of-mirna-mrna-interaction-network-in-breast-cancer-with-brain-metastasis
#17
Zhixin Li, Zhiqiang Peng, Siyu Gu, Junfang Zheng, Duiping Feng, Qiong Qin, Junqi He
BACKGROUND: MicroRNAs (miRNAs) have been linked to a number of cancer types including breast cancer. The rate of brain metastases is 10-30% in patients with advanced breast cancer which is associated with poor prognosis. The potential application of miRNAs in the diagnostics and therapeutics of breast cancer with brain metastasis is an area of intense interest. In an initial effort to systematically address the differential expression of miRNAs and mRNAs in primary breast cancer which may provide clues for early detection of brain metastasis, we analyzed the consequent changes in global patterns of gene expression in Gene Expression Omnibus (GEO) data set obtained by microarray from patients with in situ carcinoma and patients with brain metastasis...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28739545/an-optimized-non-destructive-protocol-for-testing-mechanical-properties-in-decellularized-rabbit-trachea
#18
M Den Hondt, B M Vanaudenaerde, E F Maughan, C R Butler, C Crowley, E K Verbeken, S E Verleden, J J Vranckx
Successful tissue-engineered tracheal transplantation relies on the use of non-immunogenic constructs, which can vascularize rapidly, support epithelial growth, and retain mechanical properties to that of native trachea. Current strategies to assess mechanical properties fail to evaluate the trachea to its physiological limits, and lead to irreversible destruction of the construct. Our aim was to develop and evaluate a novel non-destructive method for biomechanical testing of tracheae in a rabbit decellularization model...
July 21, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28739170/bilateral-buccinator-myomucosal-flap-outcomes-in-nonsyndromic-patients-with-repaired-cleft-palate-and-velopharyngeal-insufficiency
#19
Rafael Denadai, Anelise Sabbag, Cassio Eduardo Raposo-Amaral, Joao Carlos P Filho, Mirian H Nagae, Cesar Augusto Raposo-Amaral
BACKGROUND: The purpose of this study was to assess speech outcomes and complication rate in nonsyndromic repaired cleft palate patients undergoing bilateral buccinator myomucosal flaps for velopharyngeal insufficiency management. METHODS: A prospective study of consecutive repaired cleft palate patients with velopharyngeal insufficiency who underwent bilateral buccinator myomucosal flaps was conducted. Three experienced evaluators performed a blinded perceptual speech evaluation (hypernasality, audible nasal emission, and intraoral pressure)...
June 28, 2017: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/28739049/polyporus-and-bupleuri-radix-effectively-alter-peripheral-circadian-clock-phase-acutely-in-male-mice
#20
Hiroaki Motohashi, Haruna Sukigara, Yu Tahara, Keisuke Saito, Mayu Yamazaki, Takuya Shiraishi, Yosuke Kikuchi, Atsushi Haraguchi, Shigenobu Shibata
In mammals, daily physiological events are precisely regulated by an internal circadian clock system. An important function of this system is to readjust the phase of the clock daily. In Japan, traditional herb medicines, so-called crude drugs (Shoyaku), are widely used for many diseases, and some are reported to affect circadian clock impairment, suggesting that some of them might have an ability to modify clock gene expression rhythms. Therefore, from selected 40 crude drugs, finding candidates that control the circadian clock phases was the first purpose of this study...
July 2017: Nutrition Research
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