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https://www.readbyqxmd.com/read/29036777/growing-and-retaining-general-practice-research-leaders-in-australia-how-can-we-do-better
#1
Mieke van Driel, Laura Deckx, Georga Cooke, Marie Pirotta, Gerard F Gill, Tania Winzenberg
BACKGROUND: The aim of this study was to explore the experiences of Australian general practitioners (GPs) with a Doctor of Philosophy (PhD) about their choice to abandon or pursue an academic career. METHODS: A qualitative study of 18 GPs (PhD obtained between 2006 and 2016) was conducted. Semi-structured telephone interviews were transcribed and analysed using concurrent thematic analysis. RESULTS: General practice researchers faced insecure career pathways...
October 2017: Australian Family Physician
https://www.readbyqxmd.com/read/29036404/the-value-of-prior-knowledge-in-machine-learning-of-complex-network-systems
#2
Dana Ferranti, David Krane, David Craft
Motivation: Our overall goal is to develop machine-learning approaches based on genomics and other relevant accessible information for use in predicting how a patient will respond to a given proposed drug or treatment. Given the complexity of this problem, we begin by developing, testing and analyzing learning methods using data from simulated systems, which allows us access to a known ground truth. We examine the benefits of using prior system knowledge and investigate how learning accuracy depends on various system parameters as well as the amount of training data available...
July 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29036239/-a-phd-completed-factors-subjectively-and-objectively-influencing-children-s-need-for-orthodontic-treatment-and-their-related-quality-of-life
#3
L Kragt-de Roos
Oral health can be measured from the perspective of the professional (objectively) and from the perspective of the patient (subjectively). However, objective and subjective oral health do not match well. The focus of this research, then, is the relationship between objective oral health, subjective oral health and oral health-related quality of life (OHRQoL) in children. These relationships were considered in connection with orthodontic problems. The research was carried out as part of the Generation R Study, a prospective study of the health of 10,000 children in Rotterdam, the Netherlands...
October 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29036238/-a-phd-completed-periodontitis-diabetes-mellitus-cardiovascular-disease-a-bermuda-triangle
#4
W J Teeuw
The relationship among periodontitis, diabetes mellitus and atherosclerotic cardiovascular disease is complex and can be thought of as a Bermuda triangle. A relationship has been demonstrated between periodontitis, a worsening in the condition of the vascular system and an increased total level of inflammatory markers. Patients with severe periodontitis also show raised levels of glycosylated haemoglobin. This means that severe periodontitis can be an early indication of diabetes mellitus. Periodontal treatment generally promotes improved blood sugar regulation in diabetes patients, an improved condition of the vascular system and a decrease in the total levels of inflammation...
October 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/29034127/socio-demographic-factors-which-significantly-relate-to-the-prediction-of-burns-severity-in-children
#5
Khalid Alnababtah, Salim Khan
BACKGROUND: Burns are considered one of the biggest wounds and the most devastating injuries humans can receive as they have prolonged consequences which are not only physical, but psychological in addition to the cost of treatment. The aim of the study was to explore the relationships between socio-demographic factors (SDF) and the incidence and mechanisms of burn injuries in children. The objectives were to identify the multiple and various factors responsible for the occurrence of significant burns in children; to explore and investigate the relationship between these factors; to critically analyse SDF on the incidence and mechanisms of burns and to develop a contextual model with a view to informing future health care policy and health promotion programmes...
2017: International Journal of Burns and Trauma
https://www.readbyqxmd.com/read/29033039/aldo-r-casta%C3%A3-eda-md-phd-recipient-of-the-lifetime-achievement-award-and-74th-president-of-the-american-association-for-thoracic-surgery
#6
EDITORIAL
Pedro J Del Nido
No abstract text is available yet for this article.
September 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29032401/fine-mapping-of-the-genic-male-sterile-ms-1-gene-in-capsicum-annuum-l
#7
Kyumi Jeong, Doil Choi, Jundae Lee
The genomic region cosegregating with the genic male-sterile ms 1 gene of Capsicum annuum L. was delimited to a region of 869.9 kb on chromosome 5 through fine mapping analysis. A strong candidate gene, CA05g06780, a homolog of the Arabidopsis MALE STERILITY 1 gene that controls pollen development, was identified in this region. Genic male sterility caused by the ms 1 gene has been used for the economically efficient production of massive hybrid seeds in paprika (Capsicum annuum L.), a colored bell-type sweet pepper...
October 14, 2017: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
https://www.readbyqxmd.com/read/29032356/cell-scientist-to-watch-mahak-sharma
#8
(no author information available yet)
Mahak Sharma graduated with a bachelor's degree in biotechnology from the Guru Gobind Singh Indraprastha University, Delhi, India. She then moved to the laboratory of Steve Caplan at the University of Nebraska Medical Center, Omaha, USA, where she received her PhD in 2009. After post-doctoral research with Michael Brenner at the Department of Rheumatology, Immunology and Allergy at Harvard Medical School, she returned to India in 2011 as an Assistant Professor at the Indian Institute of Science, Education and Research (IISER) in Mohali...
October 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29027373/to-mb-phd-or-not-to-mb-phd
#9
Jonathan Cm Wan, Ada Ed Teo, Christopher E McMurran, Vishal Rawji
No abstract text is available yet for this article.
October 12, 2017: Clinical Teacher
https://www.readbyqxmd.com/read/29027147/antonio-j-torres-md-phd
#10
Antonio J Torres
No abstract text is available yet for this article.
October 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29023710/2017-german-society-for-immunology-phd-and-postdoctoral-prizes-q-a-with-the-winners
#11
(no author information available yet)
No abstract text is available yet for this article.
October 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/29023139/sheltering-haitian-humanitarian-parolees-in-san-diego-a-local-health-department-s-response-to-an-international-crisis
#12
Catherine L Blaser, Christine Murto
From the Field is a semi-regular column that explores what it means to be a local health professional on the front lines of an emergency. National Association of County and City Health Officials (NACCHO) members share their stories of preparing for and responding to disasters, epidemics, and other major health issues. Through exploring the analysis of the challenges faced and the solutions developed, readers can learn how these public health champions keep their communities safe even in extreme situations. Readers may submit topics of interest to the column's editor, Meghan McGinty, PhD, MPH, MBA, at mmcginty@naccho...
October 12, 2017: Health Security
https://www.readbyqxmd.com/read/29021563/non-canonical-reader-modules-of-baz1a-promote-recovery-from-dna-damage
#13
Mariano Oppikofer, Meredith Sagolla, Benjamin Haley, Hui-Min Zhang, Sarah K Kummerfeld, Jawahar Sudhamsu, E Megan Flynn, Tianyi Bai, Jennifer Zhang, Claudio Ciferri, Andrea G Cochran
Members of the ISWI family of chromatin remodelers mobilize nucleosomes to control DNA accessibility and, in some cases, are required for recovery from DNA damage. However, it remains poorly understood how the non-catalytic ISWI subunits BAZ1A and BAZ1B might contact chromatin to direct the ATPase SMARCA5. Here, we find that the plant homeodomain of BAZ1A, but not that of BAZ1B, has the unusual function of binding DNA. Furthermore, the BAZ1A bromodomain has a non-canonical gatekeeper residue and binds relatively weakly to acetylated histone peptides...
October 11, 2017: Nature Communications
https://www.readbyqxmd.com/read/29020682/the-impact-of-theoretical-orientation-and-training-on-preference-for-diagnostic-models-of-personality-pathology
#14
Amy Paggeot, Sharon Nelson, Steven Huprich
The role of theoretical orientation in determining preference for different methods of diagnosis has been largely unexplored. The goal of the present study was to explore ratings of the usefulness of 4 diagnostic methods after applying them to a patient: prototype ratings derived from the SWAP-II, the DSM-5 Section III specific personality disorders, the DSM-5 Section III trait model, and prototype ratings derived from the Psychodynamic Diagnostic Manual (PDM). Three hundred and twenty-nine trainees in APA-accredited doctoral programs and internships rated one of their current patients with each of the 4 diagnostic methods...
October 12, 2017: Psychopathology
https://www.readbyqxmd.com/read/29020631/covalent-modifications-of-histone-h3k9-promote-binding-of-chd3
#15
Adam H Tencer, Khan L Cox, Luo Di, Joseph B Bridgers, Jie Lyu, Xiaodong Wang, Jennifer K Sims, Tyler M Weaver, Hillary F Allen, Yi Zhang, Jovylyn Gatchalian, Michael A Darcy, Matthew D Gibson, Jinzen Ikebe, Wei Li, Paul A Wade, Jeffrey J Hayes, Brian D Strahl, Hidetoshi Kono, Michael G Poirier, Catherine A Musselman, Tatiana G Kutateladze
Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) whose functional significance is not well established. Here, we show that CHD3 co-localizes with the other NuRD subunits, including HDAC1, near the H3K9ac-enriched promoters of the NuRD target genes. The tandem PHD fingers of CHD3 bind histone H3 tails and posttranslational modifications that increase hydrophobicity of H3K9-methylation or acetylation (H3K9me3 or H3K9ac)-enhance this interaction...
October 10, 2017: Cell Reports
https://www.readbyqxmd.com/read/29017928/the-implantable-cardioverter-defibrillator-computed-respiratory-disturbance-index-accurately-identifies-severe-sleep-apnea-the-dasap-hf-study
#16
Antonio D'Onofrio, Maria Teresa La Rovere, Michele Emdin, Alessandro Capucci, Gianfranco Sinagra, Valter Bianchi, Ennio Pisanò, Paolo Pieragnoli, Maurizio Tespili, Mario Luzi, Antonello Talarico, Massimo Zecchin, Antonio Rapacciuolo, PhD Marcello Piacenti, Ciro Indolfi, Miguel Angel Arias, Igor Diemberger, Catia Checchinato, Giuseppe Boriani, Luigi Padeletti
BACKGROUND: Sleep apnea (SA) is a relevant issue in the management of heart failure patients for risk stratification and for implementing treatment strategies. OBJECTIVE: To evaluate in patients with implantable cardioverter defibrillators (ICDs) the performance of the Respiratory Disturbance Index (RDI) computed by the ApneaScan™ algorithm (Boston Scientific Inc., Natick, MA, USA), as a discriminator of severe SA. METHODS: ICD indicated patients with left ventricular ejection fraction ≤35% were enrolled...
October 7, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29016251/addressing-the-problem-of-obesity-and-associated-cardiometabolic-risk-in-black-south-african-women-time-for-action
#17
Julia H Goedecke
The PhD thesis of Gradidge, entitled 'Factors associated with obesity and metabolic syndrome in an ageing cohort of black women living in Soweto, Johannesburg (Study of Women in and Entering Endocrine Transition [SWEET])', attempts to understand the determinants of obesity and metabolic syndrome (MetS) in a population of urban-dwelling black South African women. A conceptual framework is presented, which positions obesity as the central risk factor for MetS, and includes the possible influence of socioeconomic status, lifestyle behaviours and body size perceptions, as key determinants of obesity...
2017: Global Health Action
https://www.readbyqxmd.com/read/29016249/factors-associated-with-obesity-and-metabolic-syndrome-in-ageing-black-south-african-women
#18
Philippe Jean-Luc Gradidge
BACKGROUND: The incidence of obesity and related metabolic diseases is high and increasing in sub-Saharan African women. Evidence on the determinants of these diseases is limited, particularly in black South African women. OBJECTIVE: This PhD review attempts to understand the determinants of obesity and metabolic syndrome (MetS) in a population of ageing urban-dwelling black South African women. METHODS: Drawing on the longitudinal Birth-to-Twenty-Plus cohort, data were collected in 2002/03 and 2012/13, including information on behavioural factors (smoking, sitting time, physical activity, smokeless tobacco, and alcohol consumption), body-size perception, body composition (measures of adiposity and lean mass), blood pressure, and cardiometabolic biomarkers (lipid profile, fasting insulin, fasting blood glucose, insulin resistance, leptin, and adiponectin)...
2017: Global Health Action
https://www.readbyqxmd.com/read/28993175/smfm-special-statement-research-to-knowledge-promoting-the-training-of-physician-scientists-in-the-biology-of-pregnancy
#19
Yoel Sadovky, Aaron B Caughey, Michelle DiVito, Mary E D'Alton, Amy P Murtha
Common disorders of pregnancy, such as preeclampsia, preterm birth, and fetal growth abnormalities, continue to challenge perinatal biologists seeking insights into disease pathogenesis that will result in better diagnosis, therapy, and disease prevention. These challenges have recently been intensified with discoveries that associate gestational diseases with long-term maternal and neonatal outcomes. Whereas modern high-throughput investigative tools enable scientists and clinicians to non-invasively probe the maternal-fetal genome, epigenome, and other analytes, their implications for clinical medicine remain uncertain...
October 6, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28991191/cooperative-localization-for-multi-auvs-based-on-gm-phd-filters-and-information-entropy-theory
#20
Lichuan Zhang, Tonghao Wang, Feihu Zhang, Demin Xu
Cooperative localization (CL) is considered a promising method for underwater localization with respect to multiple autonomous underwater vehicles (multi-AUVs). In this paper, we proposed a CL algorithm based on information entropy theory and the probability hypothesis density (PHD) filter, aiming to enhance the global localization accuracy of the follower. In the proposed framework, the follower carries lower cost navigation systems, whereas the leaders carry better ones. Meanwhile, the leaders acquire the followers' observations, including both measurements and clutter...
October 8, 2017: Sensors
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