keyword
MENU ▼
Read by QxMD icon Read
search

PHD

keyword
https://www.readbyqxmd.com/read/29449270/internship-experiences-contribute-to-confident-career-decision-making-for-doctoral-students-in-the-life-sciences
#1
Alexandra M Schnoes, Anne Caliendo, Janice Morand, Teresa Dillinger, Michelle Naffziger-Hirsch, Bruce Moses, Jeffery C Gibeling, Keith R Yamamoto, Bill Lindstaedt, Richard McGee, Theresa C O'Brien
The Graduate Student Internships for Career Exploration (GSICE) program at the University of California, San Francisco (UCSF), offers structured training and hands-on experience through internships for a broad range of PhD-level careers. The GSICE program model was successfully replicated at the University of California, Davis (UC Davis). Here, we present outcome data for a total of 217 PhD students participating in the UCSF and UC Davis programs from 2010 to 2015 and 2014 to 2015, respectively. The internship programs at the two sites demonstrated comparable participation, internship completion rates, and overall outcomes...
2018: CBE Life Sciences Education
https://www.readbyqxmd.com/read/29446388/train-phd-students-to-be-thinkers-not-just-specialists
#2
Gundula Bosch
No abstract text is available yet for this article.
February 15, 2018: Nature
https://www.readbyqxmd.com/read/29444951/cell-scientist-to-watch-susana-godinho
#3
(no author information available yet)
Susana Godinho graduated with a master's degree in biology from the University of Lisbon, Portugal. She then pursued her PhD with Alvaro Tavares at the Gulbenkian Institute of Science, including a year at the University of Cambridge, UK, in the laboratory of David Glover. In 2006, she joined the laboratory of David Pellman at the Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA, to work on the mechanisms of extra centrosome clustering in cancer cells during mitosis. Susana established her own research group at the Barts Cancer Institute, Queen Mary University of London (QMUL), in 2013...
February 14, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29444736/recognition-of-the-complexity-facing-residential-care-homes-a-practitioner-inquiry
#4
Jenny Dudman, Julienne Meyer, Cheryl Holman, Wendy Moyle
Aim To explore the experiences and challenges for residential care home staff when managing the healthcare needs of their residents, in particular those living with dementia. BACKGROUND: Increasing number of older people, with complex health and social care needs are living in residential care homes. Yet there is limited appreciation of why staff sometimes struggle to manage residents' healthcare needs, or understanding of their working relationship with district nurses (DNs), whose responsibility it is to provide nursing support...
February 15, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29444144/improved-ggiw-phd-filter-for-maneuvering-non-ellipsoidal-extended-targets-or-group-targets-tracking-based-on-sub-random-matrices
#5
Zhibing Liang, Fuxian Liu, Jiale Gao
For non-ellipsoidal extended targets and group targets tracking (NETT and NGTT), using an ellipsoid to approximate the target extension may not be accurate enough because of the lack of shape and orientation information. In consideration of this, we model a non-ellipsoidal extended target or target group as a combination of multiple ellipsoidal sub-objects, each represented by a random matrix. Based on these models, an improved gamma Gaussian inverse Wishart probability hypothesis density (GGIW-PHD) filter is proposed to estimate the measurement rates, kinematic states, and extension states of the sub-objects for each extended target or target group...
2018: PloS One
https://www.readbyqxmd.com/read/29444071/the-phd-finger-protein-spp1-has-distinct-functions-in-the-set1-and-the-meiotic-dsb-formation-complexes
#6
Céline Adam, Raphaël Guérois, Anna Citarella, Laura Verardi, Florine Adolphe, Claire Béneut, Vérane Sommermeyer, Claire Ramus, Jérôme Govin, Yohann Couté, Valérie Borde
Histone H3K4 methylation is a feature of meiotic recombination hotspots shared by many organisms including plants and mammals. Meiotic recombination is initiated by programmed double-strand break (DSB) formation that in budding yeast takes place in gene promoters and is promoted by histone H3K4 di/trimethylation. This histone modification is recognized by Spp1, a PHD-finger containing protein that belongs to the conserved histone H3K4 methyltransferase Set1 complex. During meiosis, Spp1 binds H3K4me3 and interacts with a DSB protein, Mer2, to promote DSB formation close to gene promoters...
February 14, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29442134/torgny-greitz-md-phd-facr-professor-of-neuroradiology-emeritus
#7
Tomas Hindmarsh, Olof Flodmark
No abstract text is available yet for this article.
February 13, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29438508/harnessing-the-power-of-communities-career-networking-strategies-for-bioscience-phd-students-and-postdoctoral-researchers
#8
Sarah Blackford
With an ever more competitive global labour market, coupled with an ever-increasing population of PhD-qualified graduates, the ability to communicate effectively and build strategic connections with others can be advantageous in the job-search process. Whether in pursuit of a tenure-track or non-academic position, many postdoctoral researchers and PhD students will benefit from networking as early as possible to enhance their career propsects. Sometimes viewed cynically as 'using people' or dismissed as 'the old boy network', the ability to make meaningful connections and build relationships can be more valuable than other job-related skills in order to gain entry to, and progress within, many professions...
February 9, 2018: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/29435217/molecular-and-cellular-mechanisms-of-hif-prolyl-hydroxylase-inhibitors-in-clinical-trials
#9
Tzu-Lan Yeh, Thomas M Leissing, Martine I Abboud, Cyrille C Thinnes, Onur Atasoylu, James P Holt-Martyn, Dong Zhang, Anthony Tumber, Kerstin Lippl, Christopher T Lohans, Ivanhoe K H Leung, Helen Morcrette, Ian J Clifton, Timothy D W Claridge, Akane Kawamura, Emily Flashman, Xin Lu, Peter J Ratcliffe, Rasheduzzaman Chowdhury, Christopher W Pugh, Christopher J Schofield
Inhibition of the human 2-oxoglutarate (2OG) dependent hypoxia inducible factor (HIF) prolyl hydroxylases (human PHD1-3) causes upregulation of HIF, thus promoting erythropoiesis and is therefore of therapeutic interest. We describe cellular, biophysical, and biochemical studies comparing four PHD inhibitors currently in clinical trials for anaemia treatment, that describe their mechanisms of action, potency against isolated enzymes and in cells, and selectivities versus representatives of other human 2OG oxygenase subfamilies...
November 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/29431885/important-and-specific-role-for-basophils-in-acute-allergic-reactions
#10
Peter Korošec, Bernhard F Gibbs, Matija Rijavec PhD, Adnan Custovic, Paul J Turner
IgE-mediated allergic reactions involve the activation of effector cells, predominantly through the high-affinity IgE receptor (FcεRI) on mast cells and basophils. Although the mast cell is considered the major effector cell during acute allergic reactions, more recent studies indicate a potentially important and specific role for basophils and their migration which occurs rapidly upon allergen challenge in humans undergoing anaphylaxis. We review the evidence for a role of basophils in contributing to clinical symptoms of anaphylaxis, and discuss the possibility that basophil trafficking during anaphylaxis might be a pathogenic (to target organs) or protective (preventing degranulation in circulation) response...
February 12, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29431640/first-person-guillaume-hatte
#11
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Guillaume Hatte is the first author on 'Tight junctions negatively regulate mechanical forces applied to adherens junctions in vertebrate epithelial tissue', published in Journal of Cell Science. Guillaume completed his PhD in the lab of Claude Prigent at CNRS UMR 6290 and Université de Rennes 1, Rennes, France, where he investigated the involvement of tight junctions during epithelial cell cytokinesis in a vertebrate model...
February 5, 2018: Journal of Cell Science
https://www.readbyqxmd.com/read/29431176/phd-forum-multimodal-iot-and-emr-based-smart-health-application-for-asthma-management-in-children
#12
Utkarshani Jaimini
According to a study done in 2014 by National Health Interview Survey around 6.3 million children in United States suffer from asthma [1]. Asthma remains one of the leading reasons for pediatric admissions to children's hospitals, and has a prevalence rate of approximately 10% in children and it leads to missed days from school and other societal costs. This occurs despite improved medications to control asthma symptoms. Asthma management is challenging as it involves understanding asthma causes and avoiding asthma triggers that are both multi-factorial and individualistic in nature...
May 2017: Proc Int Conf Smart Comput SMARTCOMP
https://www.readbyqxmd.com/read/29430827/solution-structure-of-the-phd-finger-from-the-human-kiaa1045-protein
#13
Kazuhide Miyamoto, Ayumi Yamashita, Kazuki Saito
Cross-brace structural motifs are required as a scaffold to design artificial RING fingers (ARFs) that function as ubiquitin ligase (E3) in ubiquitination and have specific ubiquitin-conjugating enzyme (E2)-binding capabilities. The Simple Modular Architecture Research Tool database predicted the amino acid sequence 131-190 (KIAA1045ZF) of the human KIAA1045 protein as an unidentified structural region. Herein, the stoichiometry of zinc ions estimated spectrophotometrically by the metallochromic indicator revealed that the KIAA1045ZF motif binds to two zinc atoms...
February 12, 2018: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29429572/mutations-in-the-baf-complex-subunit-dpf2-are-associated-with-coffin-siris-syndrome
#14
Georgia Vasileiou, Silvia Vergarajauregui, Sabine Endele, Bernt Popp, Christian Büttner, Arif B Ekici, Marion Gerard, Nuria C Bramswig, Beate Albrecht, Jill Clayton-Smith, Jenny Morton, Susan Tomkins, Karen Low, Astrid Weber, Maren Wenzel, Janine Altmüller, Yun Li, Bernd Wollnik, George Hoganson, Maria-Renée Plona, Megan T Cho, Christian T Thiel, Hermann-Josef Lüdecke, Tim M Strom, Eduardo Calpena, Andrew O M Wilkie, Dagmar Wieczorek, Felix B Engel, André Reis
Variants affecting the function of different subunits of the BAF chromatin-remodelling complex lead to various neurodevelopmental syndromes, including Coffin-Siris syndrome. Furthermore, variants in proteins containing PHD fingers, motifs recognizing specific histone tail modifications, have been associated with several neurological and developmental-delay disorders. Here, we report eight heterozygous de novo variants (one frameshift, two splice site, and five missense) in the gene encoding the BAF complex subunit double plant homeodomain finger 2 (DPF2)...
February 5, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29427526/nup98-bptf-gene-fusion-identified-in-primary-refractory-acute-megakaryoblastic-leukemia-of-infancy
#15
Mathieu Roussy, Mélanie Bilodeau, Loubna Jouan, Pauline Tibout, Louise Laramée, Emmanuelle Lemyre, Sophie Cardin, Camille Sauvageau, Françoise Couture, Aurélien Choblet, Natalie Patey, Patrick Gendron, Michel Duval, Pierre Teira, Josée Hébert, Brian T Wilhelm, John K Choi, Tanja A Gruber, Henrique Bittencourt, Sonia Cellot
The advent of large scale genomic sequencing technologies significantly improved the molecular classification of acute megakaryoblastic leukaemia (AMKL). AMKL represents a subset (∼10%) of high fatality pediatric acute myeloid leukemia (AML). Recurrent and mutually exclusive chimeric gene fusions associated with pediatric AMKL are found in 60-70% of cases and include RBM15-MKL1, CBFA2T3-GLIS2, NUP98-KDM5A and MLL rearrangements. In addition, another 4% of AMKL harbor NUP98 rearrangements (NUP98r), with yet undetermined fusion partners...
February 10, 2018: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29425347/jeroen-bax-md-phd-president-of-the-european-society-of-cardiology-he-is-a-little-more-than-halfway-through-his-2-year-term-as-president-of-the-european-society-of-cardiology-esc-but-jeroen-bax-can-already-hear-the-clock-ticking
#16
https://www.readbyqxmd.com/read/29424241/the-challenges-of-fertility-preservation-in-cancer-patients-an-interview-with-michael-grynberg
#17
Michael Grynberg
Michaël Grynberg is an Obstetrician Gynecologist specialized in reproductive medicine. After 1 year as a visiting fellow in the Department of Reproductive Medicine at Cornell University, he returned to work in France as an Attending Physician in the Division of Reproductive Medicine at the University Hôpital Antoine Béclère, Clamart, France. In 2011, he completed his PhD on the topic of the regulation of follicular growth and anti-Müllerian hormone production. Since 2014, he has been Professor of Reproductive Medicine and the Head of the Department of Reproductive Medicine and Fertility Preservation at the University Hospital Jean Verdier, Bondy, France...
February 9, 2018: Future Oncology
https://www.readbyqxmd.com/read/29423005/transcription-factor-phf19-positively-regulates-germinal-center-reactions-that-underlies-its-role-in-rheumatoid-arthritis
#18
Fanyou Ning, Chong Wang, Suling Niu, Haiyan Xu, Kai Xia, Nan Wang
The Polycomb Repressive Complex 2 (PRC2) component PHD Finger Protein 19 (phf19) gene has been identified to be associated with rheumatoid arthritis (RA) risk. Here we show that Phf19 is highly expressed in murine germinal centers (GCs) and RA patients. To investigate the function of Phf19 in lymphocytes, we generated RAG1-deficient mice reconstituted with Phf19 or control-vector transduced bone marrow (BM) cells. Lymphogenesis in primary lymphoid tissues of Phf19-RM is normal, however, Phf19-RM form enlarged GCs and generate more antibody-secreting cells (ASCs)...
2018: American Journal of Translational Research
https://www.readbyqxmd.com/read/29420663/research-matters-how-a-brother-with-down-syndrome-inspired-a-phd-in-tuberculosis-and-an-ardor-for-science-communication
#19
Meredith Wright
No abstract text is available yet for this article.
February 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29415984/uhrf1-depletion-sensitizes-retinoblastoma-cells-to-chemotherapeutic-drugs-via-downregulation-of-xrcc4
#20
Heng He, Chunsik Lee, Jong Kyong Kim
UHRF1 (ubiquitin-like with PHD and ring finger domains 1) is highly expressed in various human cancers including retinoblastoma, and associated with tumor-promoting effects such as inhibition of apoptosis and high proliferation. However, the molecular mechanisms underlying tumor-promoting functions of UHRF1 in retinoblastoma still remain elusive. Here, we show that stable knockdown of UHRF1 renders retinoblastoma cells sensitized to conventional chemotherapeutic drugs such as etoposide and camptothecin, resulting in enhanced DNA damage and apoptotic cell death...
February 7, 2018: Cell Death & Disease
keyword
keyword
71374
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"