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https://www.readbyqxmd.com/read/29233858/enhancement-of-glycolysis-by-inhibition-of-oxygen-sensing-prolyl-hydroxylases-protects-alveolar-epithelial-cells-from-acute-lung-injury
#1
Kentaro Tojo, Nao Tamada, Yusuke Nagamine, Takuya Yazawa, Shuhei Ota, Takahisa Goto
Cellular bioenergetic failure caused by mitochondrial dysfunction is a key process of alveolar epithelial injury during acute respiratory distress syndrome (ARDS). Prolyl hydroxylases (PHDs) act as cellular oxygen sensors, and their inhibition activates hypoxia-inducible factor (HIF), resulting in enhanced cellular glycolytic activity, which could compensate for impaired mitochondrial function and protect alveolar epithelial cells from ARDS. Here, we evaluated the effects of pharmacological PHD inhibition with dimethyloxalylglycine (DMOG) on alveolar epithelial cell injury using in vitro and in vivo ARDS models...
December 12, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29233170/acceptance-of-a-systematic-review-as-a-thesis-survey-of-biomedical-doctoral-programs-in-europe
#2
Livia Puljak, Damir Sapunar
BACKGROUND: Systematic reviews (SRs) have been proposed as a type of research methodology that should be acceptable for a graduate research thesis. The aim of this study was to analyse whether PhD theses in European biomedical graduate programs can be partly or entirely based on SRs. METHODS: In 2016, we surveyed individuals in charge of European PhD programs from 105 institutions. The survey asked about acceptance of SRs as the partial or entire basis for a PhD thesis, their attitude towards such a model for PhD theses, and their knowledge about SR methodology...
December 12, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29230384/non-canonical-mechanisms-regulating-hypoxia-inducible-factor-1-alpha-in-cancer
#3
REVIEW
Luisa Iommarini, Anna Maria Porcelli, Giuseppe Gasparre, Ivana Kurelac
Hypoxia-inducible factor 1 alpha (HIF-1α) orchestrates cellular adaptation to low oxygen and nutrient-deprived environment and drives progression to malignancy in human solid cancers. Its canonical regulation involves prolyl hydroxylases (PHDs), which in normoxia induce degradation, whereas in hypoxia allow stabilization of HIF-1α. However, in certain circumstances, HIF-1α regulation goes beyond the actual external oxygen levels and involves PHD-independent mechanisms. Here, we gather and discuss the evidence on the non-canonical HIF-1α regulation, focusing in particular on the consequences of mitochondrial respiratory complexes damage on stabilization of this pleiotropic transcription factor...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/29229618/recent-evolution-of-the-treatment-of-coronary-artery-disease-in-china-a-conversation-with-ya-ling-han-md-phd
#4
Ya-Ling Han, John D Rutherford
No abstract text is available yet for this article.
December 12, 2017: Circulation
https://www.readbyqxmd.com/read/29229231/associations-between-social-functioning-adhd-symptomatology-and-emotion-functioning-in-children-with-autism-spectrum-disorder-and-williams-syndrome
#5
Rowena Ng PhD, Ursula Bellugi EdD, Doris Trauner Md
No abstract text is available yet for this article.
November 6, 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/29229074/factors-associated-with-faculty-participation-in-research-activities-in-dental-schools
#6
Allan Pau, Hanan Omar, Saad Khan, Ammar Jassim, Liang Lin Seow, Chooi Gait Toh
BACKGROUND: To quantify participation in dental research activities in Malaysia, and investigate its association with socio-demographic and professional characteristics, and perceptions of research and development (R&D) culture. MATERIALS AND METHODS: Dental academics in Malaysian dental schools were invited to complete a questionnaire by email and post. The survey comprised questions on research activities in the past 12 months, socio-demographic and professional characteristics, and the R&D Culture Index...
December 2017: Singapore Dental Journal
https://www.readbyqxmd.com/read/29227435/appreciation-of-jcehp-editor-in-chief-emeritus-curtis-a-olson-phd-2010-to-2017
#7
Mary G Turco
No abstract text is available yet for this article.
October 2017: Journal of Continuing Education in the Health Professions
https://www.readbyqxmd.com/read/29223792/prediction-of-persistent-hemodynamic-depression-after-carotid-angioplasty-and-stenting-using-artificial-neural-network-model
#8
Jin Pyeong Jeon, Chulho Kim, Byoung-Doo Oh, Sun Jeong Kim, Yu-Seop Kim
OBJECTIVES: To assess and compare predictive factors for persistent hemodynamic depression (PHD) after carotid artery angioplasty and stenting (CAS) using artificial neural network (ANN) and multiple logistic regression (MLR) or support vector machines (SVM) models. PATIENTS AND METHODS: A retrospective data set of patients (n=76) who underwent CAS from 2007 to 2014 was used as input (training cohort) to a back-propagation ANN using TensorFlow platform. PHD was defined when systolic blood pressure was less than 90mmHg or heart rate was less 50 beats/min that lasted for more than one hour...
December 5, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29223678/protein-sparing-therapies-in-acute-illness-and-obesity-a-review-of-george-blackburn-s-contributions-to-nutrition-science
#9
REVIEW
Dylan D Thomas, Nawfal W Istfan, Bruce R Bistrian, Caroline M Apovian
Protein sparing therapies were developed to mitigate the harms associated with protein-calorie malnutrition and nitrogen losses induced by either acute illness or hypocaloric diets in patients with obesity. We review the development of protein sparing therapies in illness and obesity with a focus on the pioneering contributions of George Blackburn, MD, PhD. He recognized that protein-calorie malnutrition is a common and serious clinical condition and developed new approaches to its treatment in hospitalized patients...
December 7, 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29223042/experiences-of-early-labour-management-from-perspectives-of-women-labour-companions-and-health-professionals-a-systematic-review-of-qualitative-evidence
#10
REVIEW
Sarah Beake Rm Ma Research Associate, Yan-Shing Chang Ba MPhil PhD Lecturer, Helen Cheyne Rm Rgn MSc PhD Professor Of Midwifery, Helen Spiby MPhil Rn Rm Professor Of Midwifery, Jane Sandall Rm MSc PhD Professor Of Social Science And Women's Health, Debra Bick
OBJECTIVES: to examine evidence of women's, labour companions' and health professionals' experiences of management of early labour to consider how this could be enhanced to better reflect women's needs. DESIGN: a systematic review of qualitative evidence. SETTING AND PARTICIPANTS: women in early labour with term, low risk singleton pregnancies, not booked for a planned caesarean birth or post-dates induction of labour, their labour companions, and health professionals responsible for early labour care (e...
November 13, 2017: Midwifery
https://www.readbyqxmd.com/read/29223041/understanding-motivations-for-dietary-supplementation-during-pregnancy-a-focus-group-study
#11
Lenka Malek PhD, Wendy J Umberger PhD, Maria Makrides PhD, Carmel T Collins PhD, Shao Jia Zhou PhD
OBJECTIVE: to increase understanding of psychosocial factors (behavioural, normative and control beliefs) motivating vitamin and mineral supplement use during pregnancy. DESIGN: ten focus group discussions and two in-depth interviews were conducted using a script comprising questions based on study objectives. All discussions were recorded, transcribed verbatim and analysed using a framework approach. SETTING: South Australia, Australia. SUBJECTS: 40 women aged 21-45 years who were either pregnant or<12 months postpartum...
November 26, 2017: Midwifery
https://www.readbyqxmd.com/read/29220600/strategies-for-collaborating-with-children-creating-partnerships-in-occupational-therapy-and-research-1st-edition-2017-by-clare-curtin-phd-otr-422-pp-soft-cover-isbn-978-1-63091-104-1-slack-incorporated-thorofare-nj-price-59-95
#12
https://www.readbyqxmd.com/read/29218723/how-do-our-values-inform-ethical-research-a-narrative-of-recognizing-colonizing-practices
#13
Peta Dzidic, Brian Bishop
How do you reconcile tensions between ethical research practice, personal values, and disciplinary values? This article focuses on an ethical challenge involving the engagement of rural Indigenous community members that emerged during my PhD fieldwork. The narrative illustrates the necessity to engage in critical reflexive research practice, a process which saw me respond to my own feelings of "wrong" and "right," contemplate a distinction between procedural ethics and virtue ethics in community-based research, explore colonizing research practices, and endeavor to reconcile an instance where the values of community psychology appeared in contest...
December 7, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/29218359/-significance-of-the-doctorate-in-scientific-medical-education
#14
Matthias Frosch
According to European and German law, the medical education of physicians must take place in a scientific degree program at a university or under the supervision of a university. To keep up the ideal of a scientific degree program, various organizations and associations, such as the German Research Foundation, the German Council of Science and Humanities and the German Medical Faculty Association, see the need for an even stronger anchoring of academic learning content in the course of study. Traditionally, a scientific project, which is carried out during the studies, provides the basis for the Doctor of Medicine (Dr...
December 7, 2017: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz
https://www.readbyqxmd.com/read/29216896/what-will-it-take-pathways-time-and-funding-australian-medical-students-perspective-on-clinician-scientist-training
#15
Diann S Eley, Charmaine Jensen, Ranjeny Thomas, Helen Benham
BACKGROUND: Clinician-scientists are in decline worldwide. They represent a unique niche in medicine by bridging the gap between scientific discovery and patient care. A national, integrated approach to training clinician-scientists, typically programs that comprise a comprehensive MD-PhD pathway, are customary. Such a pathway is lacking in Australia. The objective was to gather perceptions from Australian medical students on factors they perceive would influence their decision to pursue clinician-scientist training...
December 8, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29216192/tracking-the-career-development-of-scientists-in-low-and-middle-income-countries-trained-through-tdr-s-research-capacity-strengthening-programmes-learning-from-monitoring-and-impact-evaluation
#16
Béatrice Halpaap, Mahnaz Vahedi, Edith Certain, Tini Alvarado, Caroline Saint Martin, Corinne Merle, Michael Mihut, Pascal Launois
The Special Programme for Research and Training in Tropical Diseases (TDR) co-sponsored by UNICEF, UNDP, World Bank and WHO has been supporting research capacity strengthening in low- and middle-income countries for over 40 years. In order to assess and continuously optimize its capacity strengthening approaches, an evaluation of the influence of TDR training grants on research career development was undertaken. The assessment was part of a larger evaluation conducted by the European Science Foundation. A comprehensive survey questionnaire was developed and sent to a group of 117 trainees supported by TDR who had completed their degree (masters or PhD) between 2000 and 2012; of these, seventy seven (77) responded...
December 7, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29214432/john-melissas-md-phd-facs
#17
John Melissas
No abstract text is available yet for this article.
December 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29209442/getting-to-phase-3-an-interview-with-virginia-s-cowen-phd-lmt
#18
EDITORIAL
Ann Blair Kennedy
I feel that it is important to know the stories behind those who are working hard in the field to bring forward massage therapy research. Interviews with massage therapy researchers will now occasionally be included in the Journal as a new editorial feature. The first interview is with Virginia S. Cowen, PhD, LMT a New York State-licensed and NCB board-certified massage therapist with a PhD from Arizona State. She first became interested in massage therapy research while in massage therapy school, and her most recent work is investigating the integration of massage therapy into medical settings...
December 2017: International Journal of Therapeutic Massage & Bodywork
https://www.readbyqxmd.com/read/29207408/joshua-p-klein-md-phd-fana-fasn-faan
#19
David M Greer
No abstract text is available yet for this article.
October 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/29206944/the-direct-and-indirect-effects-of-kisspeptin-54-on-granulosa-lutein-cell-function
#20
L A Owens, A Abbara, A Lerner, S O'floinn, G Christopoulos, S Khanjani, R Islam, K Hardy, A C Hanyaloglu, S A Lavery, W S Dhillo, S Franks
STUDY QUESTION: What are the in vivo and in vitro actions of kisspeptin-54 on the expression of genes involved in ovarian reproductive function, steroidogenesis and ovarian hyperstimulation syndrome (OHSS) in granulosa lutein (GL) cells when compared with traditional triggers of oocyte maturation? SUMMARY ANSWER: The use of kisspeptin-54 as an oocyte maturation trigger augmented expression of genes involved in ovarian steroidogenesis in human GL cells including, FSH receptor (FSHR), LH/hCG receptor (LHCGR), steroid acute regulatory protein (STAR), aromatase, estrogen receptors alpha and beta (ESR1, ESR2), 3-beta-hydroxysteroid dehydrogenase type 2 (3BHSD2) and inhibin A (INHBA), when compared to traditional maturation triggers, but did not alter markers of OHSS...
December 1, 2017: Human Reproduction
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