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Lori Wiener, Robert B Noll
No abstract text is available yet for this article.
April 18, 2018: Pediatric Blood & Cancer
Chaobin He, Yize Mao, Jun Wang, Yunda Song, Xin Huang, Xiaojun Lin, Shengping Li
BACKGROUND: Combined hepatocellular cholangiocarcinoma (cHCC-CC) is a rare form of primary liver tumor. A specific staging system for predicting survival in patients with cHCC-CC is not available. The aim of the present study was to evaluate the ability of staging systems and inflammation-based scores to predict overall survival (OS) and progression-free survival (PFS) of patients with cHCC-CC after surgical resection. METHODS: The data from 99 patients with cHCC-CC after surgical resection from June 2000 and January 2017 were retrospectively collected...
April 17, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Gareth H Rees, Peter Crampton, Robin Gauld, Stephen MacDonell
Health workforce planning aims to meet a health system's needs with a sustainable and fit-for-purpose workforce, although its efficacy is reduced in conditions of uncertainty. This PhD breakthrough article offers foresight as a means of addressing this uncertainty and models its complementarity in the context of the health workforce planning problem. The article summarises the findings of a two-case multi-phase mixed method study that incorporates actor analysis, scenario development and policy Delphi. This reveals a few dominant actors of considerable influence who are in conflict over a few critical workforce issues...
January 1, 2018: Health Services Management Research
Karel Šonka
No abstract text is available yet for this article.
2018: Prague Medical Report
Brian Greenwood, Oumar Gaye, Moses R Kamya, Gibson Kibiki, Victor Mwapasa, Kamija S Phiri, Harry Tagbor, Dianne Terlouw, Imelda Bates, Alister Craig, Pascal Magnussen, Thor G Theander, Amit Bhasin, Hazel McCullough, David Schellenberg
Substantial progress has been made in the control of malaria in Africa but much remains to be done before malaria elimination on the continent can be achieved. Further progress can be made by enhancing uptake of existing control tools but, in high transmission areas, additional tools will be needed. Development and evaluation of these new tools will require a substantial cadre of African scientists well trained in many different disciplines. This paper describes the activities undertaken by the Malaria Capacity Development Consortium (MCDC) to support the careers of PhD students and postdoctoral fellows undertaking research on malaria at five African universities...
2018: BMJ Global Health
Meenakshi Prabhune
Written by Meenakshi Prabhune, PhD Will recent advances in single-cell analysis methods help us better understand and improve human health?
April 2018: BioTechniques
Yunting Jian, Meng Wang, Yan Zhang, Ruizhang Ou, Ziyuan Zhu, Yangying Ou, Xiangfu Chen, Xin Liang, Yanqing Ding, Libing Song, Xuehu Xu, Wenting Liao
Jade family PHD finger 3 (JADE3) plays a role in inducing histone acetylation during transcription, and is involved in the progression of several human cancers; however, its role in colon cancer remains unclear. Herein, we found that JADE3 was markedly upregulated in colon cancer tissues and significantly correlated with cancer progression, and predicted shorter patient survival. Further, JADE3 was expressed much higher in colon cancer cell lines that are enriched with a stem-like signature. Overexpression of JADE3 increased, while silencing JADE3 reduced cancer stem cell-like traits in colon cancer cells in vitro and in vivo...
April 13, 2018: Cancer Letters
Gloria Lee, Joseph Plaksin, Ravichandran Ramasamy, Gabrielle Gold-von Simson
Drug discovery and development (DDD) is a collaborative, dynamic process of great interest to researchers, but an area where there is a lack of formal training. The Drug Development Educational Program (DDEP) at New York University was created in 2012 to stimulate an improved, multidisciplinary DDD workforce by educating early stage scientists as well as a variety of other like-minded students. The first course of the program emphasizes post-compounding aspects of DDD; the second course focuses on molecular signaling pathways...
2018: Journal of Translational Science
Suman Abhishek, M Angel Nivya, Naveen Kumar Nakarakanti, Waghela Deeksha, Sanjeev Khosla, Eerappa Rajakumara
UHRF1 is a multi-domain protein comprising of a tandem tudor (UHRF1 TTD), a PHD finger, and a SET and RING-associated domain. It is required for the maintenance of CG methylation, heterochromatin formation and DNA repair. Isothermal titration calorimetry binding studies of unmodified and methylated lysine histone peptides establish that the UHRF1 TTD binds dimethylated Lys9 on histone H3 (H3K9me2). Further, MD simulation and binding studies reveal that TTD-PHD of UHRF1 (UHRF1 TTD-PHD) preferentially recognizes dimethyl-lysine status...
April 12, 2018: Biochimie
(no author information available yet)
First Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Xuan Xie is the first author on 'Deubiquitylases USP5 and USP13 are recruited to and regulate heat-induced stress granules through their deubiquitylating activities', published in Journal of Cell Science. Xuan is a PhD student in the lab of Masayuki Komada at the Tokyo Institute of Technology, Yokohama, Japan, investigating the roles of ubiquitylation and deubiquitylation in the regulation of stress granules...
April 12, 2018: Journal of Cell Science
Emma A Morrison, Samuel Bowerman, Kelli L Sylvers, Jeff Wereszczynski, Catherine A Musselman
Histone tails harbor a plethora of post-translational modifications that direct the function of chromatin regulators, which recognize them through effector domains. Effector domain/histone interactions have been broadly studied, but largely using peptide fragments of histone tails. Here, we extend these studies into the nucleosome context and find that the conformation adopted by the histone H3 tails is inhibitory to BPTF PHD finger binding. Using NMR spectroscopy and MD simulations, we show that the H3 tails interact robustly but dynamically with nucleosomal DNA, substantially reducing PHD finger association...
April 12, 2018: ELife
Fatemeh Hajihosseini, Mansoureh Zagheri Tafreshi, Meimanat Hosseini, Ahmad Reza Baghestani
Background: Exploring the expectations of postgraduate nursing students from their supervisors is required in order to meet the expectations, raise the general students' satisfaction, and enhance the students' capabilities to the highest degree possible. The present study was conducted to explore the expectations of postgraduate nursing students from their supervisors. Materials and Methods: This qualitative study was done through semi-structured individual interviews with seven PhD students and 14 master's students in two focus groups from three universities in Tehran, Iran...
March 2018: Iranian Journal of Nursing and Midwifery Research
Rex D Archer, Abby Edsall
From the Field is a semi-regular column that explores what it means to be a local health professional on the front lines of an emergency. Typically, National Association of County and City Health Officials (NACCHO) members share their stories of preparing for and responding to disasters, epidemics, and other major health issues. Through exploring the analysis of the challenges faced and the solutions developed, readers can learn how these public health champions keep their communities safe even in extreme situations...
March 2018: Health Security
(no author information available yet)
Aponte, J. (2017): Acknowledgment of Reviewers. Hispanic Health Care International, 15, 200. Doi: 10.1177/1540415317746248 In the above "Acknowledgement of Reviewers", published in issue 15(4), nine reviewer names were not listed in the 'Acknowledgement to Reviewers' section. Please find below the names of the additional nine reviewers for 2017. The editor would also like to thank these reviewers for their participation and service to Hispanic Health Care International in 2017. María Luisa F. Arias, PhD, RN John Cowden, MD, MPH Giovanna De Oliveira, PhD, MSN, ARNP, ANP-C, PMHNP-BC Esther C...
March 2018: Hispanic Health Care International: the Official Journal of the National Association of Hispanic Nurses
Michael Stocker
No abstract text is available yet for this article.
April 5, 2018: Nature
Chuanyuan Wei, Nanhang Lu, Lu Wang, Yong Zhang, Zihao Feng, Yanwen Yang, Fazhi Qi, Jianying Gu
Melanoma is the most aggressive cutaneous cancer due to its propensity to metastasise and proliferate. Melanoma accounts for 80‑90% of skin‑cancer related deaths worldwide. Alhough numerous published studies have attempted to define the markers of diagnosis and prognosis of melanoma, a sensitive and specific biomarker for melanoma remains unknown. Recently, ubiquitin‑like with PHD and ring finger domains 1 (UHRF1) has attracted attention due to its role in cell proliferation and it has been deemed as a potential therapeutic target for cancer...
April 4, 2018: Oncology Reports
Shearwood McClelland, Timur Mitin, Lynn D Wilson, Charles R Thomas, Jerry J Jaboin
PURPOSE: To assess h-index data and their association with radiation oncology resident choice of academic versus private-practice career, using a recent resident graduating class. METHODS AND MATERIALS: A list of 2016 radiation oncology resident graduates (163 residents from 76 Accreditation Council for Graduate Medical Education-certified programs) and their postresidency career choice (academic vs private practice) was compiled. The Scopus bibliometric citation database was then searched to collect h-index data for each resident...
May 1, 2018: International Journal of Radiation Oncology, Biology, Physics
Robert Gc Riis
Knee osteoarthritis (KOA) is one of the most common causes of physical disability in the elderly population. With an increasing ageing and obese population, the prevalence of KOA is expected to rise substantially. The needs for a better understanding of the disease and tools that can predict the course of the disease, for example following treatment, are therefore imperative. 

Inflammation has over the last years been recognised as an important factor for both the symptomatology and disease course in KOA...
April 2018: Danish Medical Journal
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