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https://www.readbyqxmd.com/read/28433523/association-of-preresidency-peer-reviewed-publications-with-radiation-oncology-resident-choice-of-academic-versus-private-practice-career
#1
Shearwood McClelland, Charles R Thomas, Lynn D Wilson, Emma B Holliday, Jerry J Jaboin
INTRODUCTION: The decision of radiation oncology residents to pursue academic versus private practice careers plays a central role in shaping the present and future of the field, but factors that are potentially predictive of this decision are lacking. This study was performed to examine the role of several factors publicly available before residency on postresidency career choice, including preresidency peer-reviewed publications (PRPs), which have been associated with resident career choice in comparably competitive subspecialties such as neurosurgery...
April 5, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28430394/structure-based-design-of-a-new-scaffold-for-cell-penetrating-peptidic-inhibitors-of-the-histone-demethylase-phf8
#2
Jerzy Dorosz, Lars Olsen, Signe Teuber Seger, Cornelia Steinhauer, Giorgos Bouras, Charlotte Helgstrand, Anders Wiuf, Michael Gajhede
The histone demethylase PHF8 catalyzes demethylation of mono- and di-methylated lysine 9 on histone H3 (H3K9me1/2) and is a transcriptional activator involved in development and cancer. Affinity and specificity of PHF8 towards H3K9me2 substrate is affected by interaction with both the catalytic domain and a PHD reader domain. The latter specifically recognizes tri-methylated lysine 4 on histone H3. A fragment of the histone H3 tail with tri-methylated lysine 4 was used as template for structure based design of a cyclic, cell-penetrating peptide that exhibits micromolar binding affinity to PHF8 in biochemical assays...
April 21, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/28427490/is-the-mortality-trend-of-ischemic-heart-disease-by-the-gbd2013-study-in-china-real
#3
Xia Wan, Gong Huan Yang
To determine the reason for the different mortality trends of ischemic heart disease (IHD) for China between Global Burden of Disease (GBD) 2010 and GBD2013, and to improve garbage code (GC) redistribution. All data were obtained from the disease surveillance points system, and two proportions for assigning chronic pulmonary heart disease (PHD) as GC to IHD were from GBD2010 and GBD2013, which were different for years before 2004. By using the GBD2013 approach, the age-standard mortality rate (ASMR) increased by 100...
March 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28427190/pygopus2-inhibits-the-efficacy-of-paclitaxel-induced-apoptosis-and-induces-multidrug-resistance-in-human-glioma-cells
#4
Cefan Zhou, Hongxia Cheng, Wenying Qin, Yi Zhang, Hui Xiong, Jing Yang, Huang Huang, Yefu Wang, Xing-Zhen Chen, Jingfeng Tang
Anti-microtubule drugs, such as paclitaxel (PTX), are extensively used for the treatment of numerous cancers. However, growing evidence has shown that PTX resistance, either intrinsic or acquired, frequently occurs in patients and results in the failure of treatment, contributing to the high cancer mortality rate. Therefore, it is necessary to identify the genes or pathways involved in anti-microtubule drug resistance for future successful treatment of cancers. Pygopus2 (Pygo2), which contains a Zn-coordinated plant homeodomain (PHD) finger domain, is critical for β-catenin-dependent transcriptional switches in normal and malignant tissues and is over-expressed in various cancers, including human brain glioma...
March 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28424805/cruising-through-the-journey-without-getting-drowned-the-saga-of-a-phd-student-in-the-netherlands
#5
Louise van Galen, Joyce Wachelder
Young medical trainees all over the world are encouraged to investigate unknown areas of medicine that need clarification. This often leads them to undertake a PhD (Doctor of Philosophy). Being curious, critical, and creative are necessary competences which enable us to engender scientific research within acute (internal) medicine. Worldwide, huge numbers of professionals are pursuing a PhD, with the aim of receiving a 'Doctor'-title. These PhD trajectories vary distinctly between countries. Since the distances in the scientific world are getting smaller and it is becoming more easy to work with each other across borders, it might be interesting to know what it requires to become an academic 'doctor' overseas...
2017: Acute Medicine
https://www.readbyqxmd.com/read/28421681/early-clinical-xenotransplantation-experiences-an-interview-with-thomas-e-starzl-md-phd
#6
REVIEW
David K C Cooper
Dr Thomas E. Starzl, who died on March 4, 2017, was one of the great pioneers of organ transplantation. He was also a pioneer in the field of xenotransplantation. In 1964, he carried out baboon kidney transplants in six patients with terminal renal disease for whom no living or deceased donor became available; graft survival was for 19-60 days, the grafts being lost largely through continuous complement activation. Between 1966 and 1974, he carried out one ex vivo liver perfusion and three orthotopic liver transplants using chimpanzees as sources of organs; graft survival was for <14 days...
March 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28421680/thomas-e-starzl-md-phd-1926-2017
#7
David K C Cooper, A Joseph Tector
No abstract text is available yet for this article.
March 2017: Xenotransplantation
https://www.readbyqxmd.com/read/28419043/confirmation-of-sexual-dimorphisms-in-metal-hypersensitivity-and-joint-pain-following-total-joint-arthroplasty-commentary-on-an-article-by-marco-s-caicedo-phd-et-al-females-with-unexplained-joint-pain-following-total-joint-arthroplasty-exhibit-a-higher-rate
#8
https://www.readbyqxmd.com/read/28418806/lactation-newsmakers-an-interview-with-laurence-grummer-strawn-mpa-ma-phd
#9
Kathleen Marinelli
No abstract text is available yet for this article.
May 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28418093/hypoxia-inducible-factor-1-alpha-does-not-regulate-osteoclastogenesis-but-enhances-bone-resorption-activity-via-prolyl-4-hydroxylase-2
#10
Philippa A Hulley, Tammie Bishop, Aude Vernet, Jurgen E Schneider, James R Edwards, Nick A Athanasou, Helen J Knowles
Osteogenic-angiogenic coupling is promoted by the Hypoxia-Inducible Factor 1-alpha (HIF-1α) transcription factor, provoking interest in HIF activation as a therapeutic strategy to improve osteoblast mineralisation and treat pathological osteolysis. However, HIF also enhances the bone resorbing activity of mature osteoclasts. It is therefore essential to determine the full effect(s) of HIF on both the formation and bone-resorbing function of osteoclasts in order to understand how they might respond to such a strategy...
April 18, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28416979/comparison-of-hemodynamic-effects-of-biventricular-versus-left-ventricular-only-pacing-in-patients-receiving-cardiac-resynchronization-therapy-a-before-after-clinical-trial
#11
Babak Faghfourian Md, Shahram Homayoonfar Md, Mahdi Rezvanjoo Md, Jalal Poorolajal Md PhD, Amir Hossein Emam Md
BACKGROUND: Biventricular (BiV) pacing is the most common mode of delivering cardiac resynchronization therapy (CRT). However, initial clinical studies have indicated that left ventricular (LV) pacing is not inferior to BiV pacing. This study was conducted to address whether LV only pacing can provide the same hemodynamic response as BiV pacing. METHODS: This before-after clinical trial was conducted at Ekbatan Hospital, from July 2012 to November 2014. Patients with a LV ejection fraction ≤35% and a QRS duration ≥0...
April 2017: Journal of Arrhythmia
https://www.readbyqxmd.com/read/28415998/effectiveness-of-current-policing-related-mental-health-interventions-in-england-and-wales-and-crisis-intervention-teams-as-a-future-potential-model-a-systematic-review
#12
Eddie Kane, Emily Evans, Farhad Shokraneh
BACKGROUND: Experiencing mental ill health adds a layer of complexity for individuals in touch with the justice system and for those responsible for working in the justice service with these individuals, such as frontline police officers. In England and Wales, there are three commonly used but not necessarily commonly designed or operated, mental health interventions associated with policing, Liaison and Diversion, Street Triage and specialist staff embedded in Police Contact Control Rooms...
April 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28415397/surface-modified-bioresorbable-electrospun-scaffolds-for-improving-hemocompatibility-of-vascular-grafts
#13
Pablo C Caracciolo, María Isabel Rial-Hermida, Florencia Montini-Ballarin, Gustavo A Abraham, Angel Concheiro, Carmen Alvarez-Lorenzo
The replacement of small-diameter vessels is one of the main challenges in tissue engineering. Moreover, the surface modification of small-diameter vascular grafts (SDVG) is a key factor in the success of the therapy due to their increased thrombogenicity and infection susceptibility caused by the lack of a functional endothelium. In this work, electrospun scaffolds were prepared from blends of poly(L-lactic acid) (PLLA) and segmented polyurethane (PHD) with a composition designed to perform as SDVG inner layer...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28412695/cell-scientist-to-watch-robert-ernst
#14
(no author information available yet)
After obtaining his diploma in human biology at the Philipps-University Marburg, Germany, Robert Ernst joined the laboratory of Lutz Schmitt and obtained his PhD (summa cum laude) at Heinrich-Heine-University Düsseldorf in 2007. For his postdoctoral work, Robert worked with Hidde Ploegh at the Whitehead Institute for Biomedical Research, USA, supported by an EMBO long-term fellowship. Afterwards, he returned to Germany, to the laboratory of Kai Simons at the Max Planck Institute of Molecular Cell Biology and Genetics in Dresden...
April 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28412394/water-soluble-chitosan-inhibits-nerve-growth-factor-and-attenuates-allergic-inflammation-in-mite-allergen-induced-allergic-rhinitis
#15
Pei-Chi Chen, Miao-His Hsieh, PhD Wen-ShuoKuo, Hui-Fan Kao, Chih-Li Hsu, Jiu-Yao Wang
Nerve growth factor induces nasal inflammation by augmenting the existing TH2 immune response, and this can be suppressed bywater-soluble chitosan, a natural, nontoxic product that provides new therapy for allergic rhinitis.
April 12, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28410972/fostering-resilience-among-mothers-under-stress-authentic%C3%A2-connections-groups-for-medical-professionals
#16
Suniya S Luthar, Alexandria Curlee, Susannah J Tye, Judith C Engelman, Cynthia M Stonnington
BACKGROUND: We report on effects of an intervention to foster resilience among professional women at high risk for stress and burnout: health care providers (physicians, PhD clinicians, physician assistants, and nurse practitioners) who are mothers. METHODS: Between February and November 2015, 40 mothers on staff at the Mayo Clinic, Arizona, were assigned randomly to either 1) 12 weekly 1-hour sessions of a structured, relational supportive intervention, the Authentic Connections Groups (n = 21) with protected time to attend sessions or to 2) 12 weekly hours of protected time to be used as desired (controls; n = 19)...
April 7, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28410688/education-and-training-of-medical-physics-in-iran-the-past-the-present-and-the-future
#17
Seyed Rabi Mahdavi, Behrouz Rasuli, Azam Niroomand-Rad
PURPOSE: The aim of this study was to investigate the current status of education and training programs in medical physics in Iran. METHODS: A questionnaire was designed and sent to 274 IAMP (Iranian Association of Medical Physicists) members focusing on these two topics: the educational situation (course syllabus, number of faculty members, number of PhD and MSc students and sub-fields offered in the department) and the professional situation (work experience, workplaces of medical physicists, postgraduate degrees that were granted and the amount of therapy and imaging equipment)...
April 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28404846/double-phd-fingers-2-dpf2-promotes-the-immune-escape-of-influenza-virus-by-suppressing-interferon-%C3%AE-production
#18
Dongjo Shin, Jihye Lee, Ji Hoon Park, Ji-Young Min
The high mutation rates of the influenza viral genome facilitate the generation of viral escape mutants, rendering vaccines and drugs against influenza virus-encoded targets potentially ineffective. Therefore, we identified host cell determinants dispensable for the host but crucial for virus replication, with the goal of preventing viral escape and finding effective antivirals. To identify these host factors, we screened 2,732 human genes using RNA interference, and focused on one of the identified host factors, the double PHD fingers 2 (DPF2/REQ) gene, for this study...
April 12, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28402695/uhrf2-regulates-local-5-methylcytosine-and-suppresses-spontaneous-seizures
#19
Yidan Liu, Bin Zhang, Xiaoyu Meng, Matthew J Korn, Jack M Parent, Lin-Yu Lu, Xiaochun Yu
The 5-methylcytosine (5mC) modification regulates multiple cellular processes and is faithfully maintained following DNA replication. In addition to DNA methyltransferase (DNMT) family proteins, ubiquitin-like PHD and ring finger domain-containing protein 1 (UHRF1) plays an important role in the maintenance of 5 mC levels. Loss of UHRF1 abolishes 5 mC in cells and leads to embryonic lethality in mice. Interestingly, UHRF1 has a paralog, UHRF2, that has similar sequence and domain architecture, but its biological function is not clear...
April 12, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28402630/benzo-isoquinoline-diones-as-potent-and-selective-inhibitors-of-brpf2-and-taf1-taf1l-bromodomains
#20
Léa Bouché, Clara D Christ, Stephan Siegel, Amaury E Fernández-Montalván, Simon J Holton, Oleg Fedorov, Antonius Ter Laak, Tatsuo Sugawara, Detlef Stöckigt, Cynthia Tallant, James M Bennett, Octovia P Monteiro, Laura Díaz-Sáez, Paulina Siejka, Julia Meier, Vera Puetter, Joerg Weiske, Susanne Müller, Kilian Veit Marcus Huber, Ingo V Hartung, Bernard Haendler
Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we describe a dual inhibitor of the bromodomain and PHD finger (BRPF) family member BRPF2 and the TATA box binding protein-associated factors TAF1 and TAF1L. These proteins are found in large chromatin complexes and play important roles in transcription regulation. The substituted benzo-isoquinoline-dione series was identified by high-througput screening and subsequent structure-activity relationship optimization allowed generation of low nanomolar BRPF2 BD inhibitors with strong selectivity against BRPF1 and BRPF3 BDs...
April 12, 2017: Journal of Medicinal Chemistry
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