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https://www.readbyqxmd.com/read/28646037/early-exposure-to-chronic-hypoxia-induces-short-and-long-term-regulation-of-hemoglobin-gene-expression-in-european-sea-bass-dicentrarchus-labrax
#1
Laura Cadiz, Arianna Servili, Patrick Quazuguel, Lauriane Madec, José-Luis Zambonino-Infante, David Mazurais
European sea bass (Dicentrarchus labrax) inhabits coastal waters and may be exposed to hypoxia at different life stages, requiring physiological and behavioral adaptation. In the present study, we attempted to determine whether regulation of hemoglobin (Hb) gene expression plays a role in the physiological response to chronic moderate hypoxia in whole larvae and hematopoietic tissues (head kidney and spleen) of juveniles. We also tested the hypothesis that hypoxia exposure at the larval stage could induce a long-term effect on the regulation of Hb gene expression...
June 23, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28643825/-a-phd-completed-10-implant-supported-removable-partial-dentures-in-a-kennedy-class-i-situation-in-the-mandible
#2
C Jensen-Louwerse
Implant-supported removable partial dentures in the mandible often cause problems, which means that patients wear their dentures seldom if at all. A solution is to place implants that the dentures can be snapped onto. There is, however, no consensus about the best position of the implants in the mandible yet. In addition, it is worthwhile to balance the cost of treatment with its effectiveness. In a randomised cross-over clinical trial involving 30 patients with a shortened dental arch, the implant-supported removable partial denture in the mandible was evaluated based on the experience of the patient, mean time of wearing, chewing ability and the clinical and radiographic parameters in relation to 2 different implant positions: 2 in the pre-molar region or 2 in the molar region...
June 2017: Nederlands Tijdschrift Voor Tandheelkunde
https://www.readbyqxmd.com/read/28642100/jcl-roundtable-future-of-the-lipid-laboratory-using-the-laboratory-to-manage-the-patient-part-2
#3
REVIEW
William Virgil Brown, Yehuda Handelsman, Seth S Martin, Pamela B Morris
The measurement of cholesterol and triglycerides as indicators of metabolic disorders and most particularly of vascular disease risk has been of growing importance to physicians and epidemiologists over the past century. This was refocused on the lipoproteins, the specific packages in blood that carry these lipids, by John Gofman, MD, PhD, and Don Fredrickson, MD, more than 50 years ago. We continue to learn about the metabolism of these large molecular structures and their relationship to arteriosclerosis as new genetic and interventional studies are published...
May 25, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28639311/increasing-the-pipeline-and-diversity-of-doctorally-prepared-nurses-description-and-preliminary-evaluation-of-a-health-disparities-summer-research-program
#4
John P Salerno, Rosa Gonzalez-Guarda, Mary Hooshmand
Despite calls to increase the number and diversity of doctorally prepared nurses, recent data indicate a severe shortage of PhD-prepared nurses, especially those of racial/ethnic minority backgrounds. This is concerning, given that evidence indicates that racial/ethnic minority PhD-prepared nurses are well-positioned to address health disparities, by attending to the needs/concerns of medically underrepresented groups. The purpose of this article is to describe and provide a preliminary evaluation of a summer research program for minority nursing students...
June 22, 2017: Public Health Nursing
https://www.readbyqxmd.com/read/28630323/role-of-the-cbp-catalytic-core-in-intramolecular-sumoylation-and-control-of-histone-h3-acetylation
#5
Sangho Park, Robyn L Stanfield, Maria A Martinez-Yamout, H Jane Dyson, Ian A Wilson, Peter E Wright
The histone acetyl transferases CREB-binding protein (CBP) and its paralog p300 play a critical role in numerous cellular processes. Dysregulation of their catalytic activity is associated with several human diseases. Previous work has elucidated the regulatory mechanisms of p300 acetyltransferase activity, but it is not known whether CBP activity is controlled similarly. Here, we present the crystal structure of the CBP catalytic core encompassing the bromodomain (BRD), CH2 (comprising PHD and RING), HAT, and ZZ domains at 2...
June 19, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28628413/sir-peter-mansfield-phd
#6
Paul A Bottomley, Andrew A Maudsley
No abstract text is available yet for this article.
July 2017: Radiology
https://www.readbyqxmd.com/read/28626588/uhrf1-is-required-for-basal-stem-cell-proliferation-in-response-to-airway-injury
#7
Handan Xiang, Lifeng Yuan, Xia Gao, Peter B Alexander, Omar Lopez, Calvin Lau, Yi Ding, Mengyang Chong, Tao Sun, Rui Chen, Si-Qi Liu, Haiyang Wu, Ying Wan, Scott H Randell, Qi-Jing Li, Xiao-Fan Wang
Cellular senescence is a cell fate characterized by an irreversible cell cycle arrest, but the molecular mechanism underlying this senescence hallmark remains poorly understood. Through an unbiased search for novel senescence regulators in airway basal cells, we discovered that the epigenetic regulator ubiquitin-like with PHD and ring finger domain-containing protein 1 (UHRF1) is critical for regulating cell cycle progression. Upon injury, basal cells in the mouse airway rapidly induce the expression of UHRF1 in order to stimulate stem cell proliferation and tissue repair...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28622522/the-egln-hif-o2-sensing-system-multiple-inputs-and-feedbacks
#8
REVIEW
Mircea Ivan, William G Kaelin
The EGLN (also called PHD) prolyl hydroxylase enzymes and their canonical targets, the HIFα subunits, represent the core of an ancient oxygen-monitoring machinery used by metazoans. In this review, we highlight recent progress in understanding the overlapping versus specific roles of EGLN enzymes and HIF isoforms and discuss how feedback loops based on recently identified noncoding RNAs introduce additional layers of complexity to the hypoxic response. Based on novel interactions identified upstream and downstream of EGLNs, an integrated network connecting oxygen-sensing functions to metabolic and signaling pathways is gradually emerging with broad therapeutic implications...
June 15, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28621180/interview-with-derek-connolly
#9
Derek Leslie Connolly
Dr Derek Connolly speaks to Adam Price-Evans, Commissioning Editor of Future Cardiology: Derek Leslie Connolly is a Consultant Interventional Cardiologist at Birmingham City Hospital (UK). He qualified from the University of Edinburgh (UK) summa cum laude in Pharmacology in 1985 and in Medicine in 1988 where he was the Brunton Medalist. As a Carnegie scholar at the University of California San Diego (CA, USA) he saw the early promise of angioplasty and changed his career plan from cardiac surgery to coronary intervention...
June 16, 2017: Future Cardiology
https://www.readbyqxmd.com/read/28620113/cell-scientist-to-watch-mads-gyrd-hansen
#10
(no author information available yet)
Mads Gyrd-Hansen studied biochemistry at the University of Copenhagen and received his PhD in 2005 under the supervision of Marja Jäättelä at the Danish Cancer Society Research Centre. He then joined the laboratory of Pascal Meier at the Institute of Cancer Research in London to work on the inhibitor of apoptosis (IAP) proteins. Mads returned to Copenhagen in 2008 to the Biotech Research and Innovation Centre (BRIC) in a senior postdoctoral position with Morten Frödin, and subsequently started his own research group with a career-development fellowship from the Danish Research Councils as part of the laboratory of Niels Mailand at the Novo Nordisk Foundation Centre for Protein Research...
June 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28619090/truffle-renaissance-in-poland-history-present-and-prospects
#11
REVIEW
Aleksandra Rosa-Gruszecka, Dorota Hilszczańska, Wojciech Gil, Bogusław Kosel
The use of truffles in Poland has a long tradition, yet due to some historical aspects, this knowledge was lost. Currently, truffles and truffle orchards are again receiving attention, and thanks to, e.g., historical data, they have solid foundations to be established. Publications relating to truffles between 1661 and 2017 were searched for in international and national databases, such as the database of PhD theses, Google Scholar, and catalogues of the National Library of Poland, the Jagiellonian Digital Library, the University Library of J...
June 15, 2017: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/28617528/influence-of-ablation-therapy-on-the-quality-of-life-in-children-with-supraventricular-tachycardia
#12
E Szafran, A Baszko, A Bukowska-Posadzy, A Łaźniak, T Moszura, A Siwińska, J Walkowiak, W Bobkowski
OBJECTIVE: Numerous restrictions, which are imposed on children with arrhythmia, influence their quality of life (QoL) and may have a negative impact on their further development. Ablation is a highly successful treatment leaving patients free from arrhythmia and other related limitations. There are very few studies evaluating the influence of ablation on the QoL in children with arrhythmia, based on small groups of patients. The aim of this study was to evaluate the impact of ablation on the QoL in children with supraventricular tachycardia (SVT)...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28615485/early-career-researchers-an-interview-with-caroline-williams
#13
(no author information available yet)
Caroline Williams is an Assistant Professor at the University of California, Berkeley, USA, where she studies evolution of metabolic physiology in ectotherms. She grew up in New Zealand, where she received Bachelor's and Master's degrees in Zoology from the University of Otago in Dunedin. After travelling and working in Asia, she moved to Western University, Canada, for her PhD in the laboratory of Brent Sinclair, before joining Dan Hahn at the University of Florida as a postdoctoral research fellow. In 2010 she received the Scholander Award from the American Physiological Society...
June 15, 2017: Journal of Experimental Biology
https://www.readbyqxmd.com/read/28613249/hypoxia-inducible-factor-2-alpha-and-prolinhydroxylase-2-polymorphisms-in-patients-with-acute-respiratory-distress-syndrome-ards
#14
Annika Dötsch, Lewin Eisele, Miriam Rabeling, Katharina Rump, Kai Walstein, Alexandra Bick, Linda Cox, Andrea Engler, Hagen S Bachmann, Karl-Heinz Jöckel, Michael Adamzik, Jürgen Peters, Simon T Schäfer
Hypoxia-inducible-factor-2α (HIF-2α) and HIF-2 degrading prolyl-hydroxylases (PHD) are key regulators of adaptive hypoxic responses i.e., in acute respiratory distress syndrome (ARDS). Specifically, functionally active genetic variants of HIF-2α (single nucleotide polymorphism (SNP) [ch2:46441523(hg18)]) and PHD2 (C/T; SNP rs516651 and T/C; SNP rs480902) are associated with improved adaptation to hypoxia i.e., in high-altitude residents. However, little is known about these SNPs' prevalence in Caucasians and impact on ARDS-outcome...
June 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28613125/lactation-newsmakers-an-interview-with-kathryn-g-dewey-ms-phd
#15
Kathleen Marinelli
No abstract text is available yet for this article.
June 1, 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28612427/simulation-based-investigation-of-deleterious-nssnp-s-in-atxn2-gene-and-its-structural-consequence-towards-spinocerebellar-ataxia
#16
Siddharth Sinha, Sharad Verma, Aditi Singh, Pallavi Somvanshi, Abhinav Grover
Spinocerebellar degeneration, termed as ataxia is a neurological disorder of central nervous system, characterized by limb in-coordination and a progressive gait. The patient also demonstrates specific symptoms of muscle weakness, slurring of speech, and decreased vibration senses. Expansion of polyglutamine trinucleotide (CAG) within ATXN2 gene with 35 or more repeats, results in spinocerebellar ataxia type-2. Protein ataxin-2 coded by ATXN2 gene has been reported to have a crucial role in translation of the genetic information through sequestering the histone acetyl transferases (HAT) resulting in a state of hypo-acetylation...
June 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28610954/feedback-regulation-of-aldoa-activates-the-hif-1%C3%AE-mmp9-axis-to-promote-lung-cancer-progression
#17
Yu-Chan Chang, Yung-Chieh Chan, Wei-Ming Chang, Yuan-Feng Lin, Chih-Jen Yang, Chia-Yi Su, Ming-Shyan Huang, Alexander T H Wu, Michael Hsiao
Distant metastasis and recurrence are the greatest challenges in the clinical management of lung cancer. Despite advances in targeted therapies, high mortality rates persist. Therefore, alternative therapeutic interventions are urgently required. Accumulating evidence indicates that normalizing tumor metabolism may be a way to increase therapeutic efficacy and to reduce tumor malignancy. Here, we analyzed integrated transcriptomics data and an shRNA library against glycolytic enzymes and found that elevated Aldolase A expression is highly correlated with metastatic potential and a poor prognosis in patients with non-small cell lung cancer (NSCLC)...
June 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28609725/new-insights-on-mitochondrial-heterogeneity-observed-in-prepared-mitochondrial-samples-following-a-method-for-freeze-fracture-and-scanning-electron-microscopy
#18
Julie A MacDonald, William H Fowle, Dori C Woods PhD
Mitochondria are dynamic intracellular organelles with diverse roles in tissue- and cell type-specific processes, extending beyond bioenergetics. In keeping with this array of functions, mitochondria are described as heterogeneous both between and within tissue types based on multiple parameters, including a broad spectrum of morphological features, and new research points toward a need for the evaluation of mitochondria as isolated organelles. Although transmission electron microscopy (TEM) is commonly used for the evaluation of mitochondria in tissues and renders mitochondrial structures in ultra-thin sections in two-dimensions, additional information regarding complex features within these organelles can be ascertained using scanning electron microscopy (SEM), which allows for analysis of phenotypic differences in three-dimensions...
June 1, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28607640/predictors-of-intention-to-marriage-based-on-theory-of-planned-behavior-among-university-students-in-iran
#19
Reza Shahrabadi, Akram Karimi-Shahanjarini, Saeed Dashti, Alireza Soltanian, Gholamreza Garmaroudi
INTRODUCTION: Marriage is a social capital in society, so that makes the behavioral and social stability of parents and children in a generation, productive. Various factors can affect the intention of marriage, including individual, economic, social and cultural factors. The present study aimed to determine predictors of university students' intention to marriage based on the theory of planned behavior (TPB). METHODS: This cross-sectional study was performed among 192 single students (Master and PhD students with five to seven years of dentistry and medicine) in Hamadan, in 2014...
April 2017: Electronic Physician
https://www.readbyqxmd.com/read/28606929/targeting-oxygen-sensing-prolyl-hydroxylase-phd-for-metformin-associated-lactic-acidosis-treatment
#20
Tomoko Oyaizu-Toramaru, Tomohiro Suhara, Noriyo Hayakawa, Takashi Nakamura, Akiko Kubo, Shizuka Minamishima, Kyoji Yamaguchi, Takako Hishiki, Hiroshi Morisaki, Makoto Suematsu, Yoji Andrew Minamishima
Metformin is one of the most widely used therapeutics for type 2 diabetes mellitus and also has anti-cancer and anti-aging properties. However, it is known to induce metformin-associated lactic acidosis (MALA), a severe medical condition with poor prognosis, especially in individuals with renal dysfunction. Inhibition of prolyl hydroxylase (PHD) is known to activate transcription factor HIF (hypoxia-inducible factor) that increases lactate efflux as a result of enhanced glycolysis, but it also enhances gluconeogenesis from lactate in the liver that contributes to reducing circulating lactate levels...
June 12, 2017: Molecular and Cellular Biology
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