Allison Brashear, Jared F Cook, Deborah F Hill, Alethea Amponsah, Beverly M Snively, Laney Light, Niki Boggs, Cynthia K Suerken, Mark Stacy, Laurie Ozelius, Kathleen J Sweadner, W Vaughn McCall
OBJECTIVE: Rapid-onset dystonia-parkinsonism (RDP) is caused by a variety of missense mutations in the ATP1A3 gene. Psychiatric comorbidity has been reported, although systematic examination of psychiatric disease in individuals with RDP is lacking. This study examines psychiatric morbidity for 23 patients with RDP in 10 families with family member control subjects and in 3 unrelated patients with RDP, totaling 56 individuals. METHODS: Twenty-nine ATP1A3 mutation-positive individuals were examined; 26 exhibited motor symptoms (motor manifesting carrier [MMC]) and 3 did not (nonmotor manifesting carriers [NMC])...
September 11, 2012: Neurology