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Hippocampal volume

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https://www.readbyqxmd.com/read/28427989/egocentric-and-allocentric-visuospatial-working-memory-in-premotor-huntington-s-disease-a-double-dissociation-with-caudate-and-hippocampal-volumes
#1
Katherine L Possin, Hosung Kim, Michael D Geschwind, Tacie Moskowitz, Erica T Johnson, Sharon J Sha, Alexandra Apple, Duan Xu, Bruce L Miller, Steven Finkbeiner, Christopher P Hess, Joel H Kramer
Our brains represent spatial information in egocentric (self-based) or allocentric (landmark-based) coordinates. Rodent studies have demonstrated a critical role for the caudate in egocentric navigation and the hippocampus in allocentric navigation. We administered tests of egocentric and allocentric working memory to individuals with premotor Huntington's disease (pmHD), which is associated with early caudate nucleus atrophy, and controls. Each test had 80 trials during which subjects were asked to remember 2 locations over 1-sec delays...
April 17, 2017: Neuropsychologia
https://www.readbyqxmd.com/read/28427704/comparison-of-brain-and-spinal-cord-magnetic-resonance-imaging-features-in-neuromyelitis-optica-spectrum-disorders-patients-with-or-without-aquaporin-4-antibody
#2
Moli Fan, Ying Fu, Lei Su, Yi Shen, Kristofer Wood, Li Yang, Yaou Liu, Fu-Dong Shi
BACKGROUND: The spinal cord and brain measurements are rarely investigated in neuromyelitis optica (NMO) patients with and without antibodies to aquaporin-4 (AQP4), directly compared to multiple sclerosis (MS) patients. OBJECTIVES: To investigate magnetic resonance imaging (MRI) features of both brain and spinal cord in NMO patients with and without antibodies to AQP4, compared with MS patients and healthy controls (HC). METHODS: We recruited 55 NMO including 30 AQP4 (+) and 25 AQP4 (-), 25 MS and 25 HC...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28425185/the-influence-of-hippocampal-atrophy-on-the-cognitive-phenotype-of-dementia-with-lewy-bodies
#3
Greg J Elder, Karen Mactier, Sean J Colloby, Rosie Watson, Andrew M Blamire, John T O'Brien, John-Paul Taylor
OBJECTIVE: The level of hippocampal atrophy in dementia with Lewy bodies (DLB) is typically less than that observed in Alzheimer's disease (AD). However, it is not known how the cognitive phenotype of DLB is influenced by hippocampal atrophy or the atrophy of adjacent medial temporal lobe structures. METHODS: Dementia with Lewy bodies (n = 65), AD (n = 76) and control (n = 63) participants underwent 3T magnetic resonance imaging and cognitive Cambridge Cognitive Examination and Mini-Mental State Examination (CAMCOG and MMSE) assessments...
April 20, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28424833/cannabis-related-hippocampal-volumetric-abnormalities-specific-to-subregions-in-dependent-users
#4
Yann Chye, Chao Suo, Murat Yücel, Lauren den Ouden, Nadia Solowij, Valentina Lorenzetti
RATIONALE: Cannabis use is associated with neuroanatomical alterations in the hippocampus. While the hippocampus is composed of multiple subregions, their differential vulnerability to cannabis dependence remains unknown. OBJECTIVES: The objective of the study is to investigate gray matter alteration in each of the hippocampal subregions (presubiculum, subiculum, cornu ammonis (CA) subfields CA1-4, and dentate gyrus (DG)) as associated with cannabis use and dependence...
April 19, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28424613/the-relationship-between-cerebral-small-vessel-disease-hippocampal-volume-and-cognitive-functioning-in-patients-with-copd-an-mri-study
#5
Fiona A H M Cleutjens, Rudolf W H M Ponds, Martijn A Spruit, Saartje Burgmans, Heidi I L Jacobs, Ed H B M Gronenschild, Julie Staals, Frits M E Franssen, Jeanette B Dijkstra, Lowie E G W Vanfleteren, Paul A Hofman, Emiel F M Wouters, Daisy J A Janssen
The neural correlates of cognitive impairment in chronic obstructive pulmonary disease (COPD) are not yet understood. Structural brain abnormalities could possibly be associated with the presence of cognitive impairment through cigarette smoke, inflammation, vascular disease, or hypoxemia in these patients. This study aimed to investigate whether macrostructural brain magnetic resonance imaging (MRI) features of cerebral small vessel disease (SVD) and hippocampal volume (HCV) are related to cognitive performance in patients with COPD...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28424082/subventricular-zones-new-key-targets-for-glioblastoma-treatment
#6
J Khalifa, F Tensaouti, A Lusque, B Plas, J-A Lotterie, A Benouaich-Amiel, E Uro-Coste, V Lubrano, E Cohen-Jonathan Moyal
BACKGROUND: We aimed to identify subventricular zone (SVZ)-related prognostic factors of survival and patterns of recurrence among patients with glioblastoma. METHODS: Forty-three patients with primary diagnosed glioblastoma treated in our Cancer Center between 2006 and 2010 were identified. All patients received surgical resection, followed by temozolomide-based chemoradiation. Ipsilateral (iSVZ), contralateral (cSVZ) and bilateral (bSVZ) SVZs were retrospectively segmented and radiation dose-volume histograms were generated...
April 20, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28420646/associations-between-left-ventricular-dysfunction-and-brain-structure-and-function-findings-from-the-sabre-southall-and-brent-revisited-study
#7
Chloe M Park, Emily D Williams, Nish Chaturvedi, Therese Tillin, Robert J Stewart, Marcus Richards, Dean Shibata, Jamil Mayet, Alun D Hughes
BACKGROUND: Subclinical left ventricular (LV) dysfunction has been inconsistently associated with early cognitive impairment, and mechanistic pathways have been poorly considered. We investigated the cross-sectional relationship between LV dysfunction and structural/functional measures of the brain and explored the role of potential mechanisms. METHOD AND RESULTS: A total of 1338 individuals (69±6 years) from the Southall and Brent Revisited study underwent echocardiography for systolic (tissue Doppler imaging peak systolic wave) and diastolic (left atrial diameter) assessment...
April 18, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28417215/the-atrophy-and-laterality-of-the-hippocampal-subfields-in-parents-with-or-without-posttraumatic-stress-disorder-who-lost-their-only-child-in-china
#8
Yifeng Luo, Yu Liu, Yaxin Qin, Xiaojie Zhang, Tieliang Ma, Wenbo Wu, Yue Yang, Di Jiang, Hairong Shan, Zhihong Cao
Investigating hippocampal subfields may provide new and important insights into the pathophysiology of posttraumatic stress disorder (PTSD). However, no study has examined the hippocampal subfield volume changes in parents with or without PTSD who had lost their only child and could no longer conceive in China. Fifty-seven parents with PTSD (PTSD+), 11 trauma-exposed parents without PTSD (PTSD-), and 39 non-traumatized controls were recruited to examine the hippocampal subfield volumes using magnetic resonance imaging...
April 17, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28416813/brain-derived-neurotrophic-factor-val-66-met-genotype-and-ovarian-steroids-interactively-modulate-working-memory-related-hippocampal-function-in-women-a-multimodal-neuroimaging-study
#9
S-M Wei, E B Baller, P D Kohn, J S Kippenhan, B Kolachana, S J Soldin, D R Rubinow, P J Schmidt, K F Berman
Preclinical evidence suggests that the actions of ovarian steroid hormones and brain-derived neurotrophic factor (BDNF) are highly convergent on brain function. Studies in humanized mice document an interaction between estrus cycle-related changes in estradiol secretion and BDNF Val(66)Met genotype on measures of hippocampal function and anxiety-like behavior. We believe our multimodal imaging data provide the first demonstration in women that the effects of the BDNF Val/Met polymorphism on hippocampal function are selectively modulated by estradiol...
April 18, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28416565/cingulo-insular-structural-alterations-associated-with-psychogenic-symptoms-childhood-abuse-and-ptsd-in-functional-neurological-disorders
#10
David L Perez, Nassim Matin, Arthur Barsky, Victor Costumero-Ramos, Sara J Makaretz, Sigrid S Young, Jorge Sepulcre, W Curt LaFrance, Matcheri S Keshavan, Bradford C Dickerson
OBJECTIVE: Adverse early-life events are predisposing factors for functional neurological disorder (FND) and post-traumatic stress disorder (PTSD). Cingulo-insular regions are implicated in the biology of both conditions and are sites of stress-mediated neuroplasticity. We hypothesised that functional neurological symptoms and the magnitude of childhood abuse would be associated with overlapping anterior cingulate cortex (ACC) and insular volumetric reductions, and that FND and PTSD symptoms would map onto distinct cingulo-insular areas...
April 17, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28414755/childhood-socioeconomic-status-and-childhood-maltreatment-distinct-associations-with-brain-structure
#11
Gwendolyn M Lawson, Joshua S Camins, Laura Wisse, Jue Wu, Jeffrey T Duda, Philip A Cook, James C Gee, Martha J Farah
The present study examined the relationship between childhood socioeconomic status (SES), childhood maltreatment, and the volumes of the hippocampus and amygdala between the ages of 25 and 36 years. Previous work has linked both low SES and maltreatment with reduced hippocampal volume in childhood, an effect attributed to childhood stress. In 46 adult subjects, only childhood maltreatment, and not childhood SES, predicted hippocampal volume in regression analyses, with greater maltreatment associated with lower volume...
2017: PloS One
https://www.readbyqxmd.com/read/28413477/isoquercetin-activates-the-erk1-2-nrf2-pathway-and-protects-against-cerebral-ischemia-reperfusion-injury-in-vivo-and-in-vitro
#12
Miao Chen, Li-Hua Dai, Aihua Fei, Shu-Ming Pan, Hai-Rong Wang
Isoquercetin has exhibited a wide range of therapeutic properties, including antioxidant, anti-inflammatory and anti-allergic activities. The aim of the present study was to investigate the effect of isoquercetin on rats with 2 h middle cerebral artery occlusion (MCAO) and evaluate the neuroprotective effect of isoquercetin on a primary culture of rat hippocampal neuronal cells subjected to oxygen-glucose deprivation followed by reoxygenation (OGD/R). In vivo, the rats treated with isoquercetin exhibited a lower degree of neurological dysfunction and smaller infarct volume than the vehicle-treated rats...
April 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28405888/effects-of-common-grm5-genetic-variants-on-cognition-hippocampal-volume-and-mglur5-protein-levels-in-schizophrenia
#13
Natalie Matosin, Kelly Anne Newell, Yann Quidé, Jessica Lee Andrews, Nina Teroganova, Melissa Jayne Green, Francesca Fernandez
GRM5 (coding for metabotropic glutamate receptor 5, mGluR5) is a promising target for the treatment of cognitive deficits in schizophrenia, but there has been little investigation of its association with cognitive and brain phenotypes within this disorder. We examined the effects of common genetic variation in GRM5 with cognitive function, hippocampal volume, and hippocampal mGluR5 protein levels in schizophrenia patients relative to healthy controls. Two independent GRM5 variants rs60954128 [C>T] and rs3824927 [G>T] were genotyped in a schizophrenia case/control cohort (n=249/261)...
April 13, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28404458/a-comparison-of-accurate-automatic-hippocampal-segmentation-methods
#14
Azar Zandifar, Vladimir Fonov, Pierrick Coupé, Jens Pruessner, D Louis Collins
The hippocampus is one of the first brain structures affected by Alzheimer's disease (AD). While many automatic methods for hippocampal segmentation exist, few studies have compared them on the same data. In this study, we compare four fully automated hippocampal segmentation methods in terms of their conformity with manual segmentation and their ability to be used as an AD biomarker in clinical settings. We also apply error correction to the four automatic segmentation methods, and complete a comprehensive validation to investigate differences between the methods...
April 9, 2017: NeuroImage
https://www.readbyqxmd.com/read/28401913/influence-of-parental-care-on-offspring-hippocampal-volume-in-young-adults-varies-as-a-function-of-overprotection
#15
Yinan Wang, Yiying Song, Xueting Li, Lin Zhang, Jia Liu
Parental care results in increased hippocampal volumes through adaptive stress responses in developing animals. However, human studies have not yet provided consistent findings analogous to the animal literature, possibly because parental care in humans is likely intermingled with parental overprotection, as suggested by the optimal parenting theory. Here, we tested the hypothesis that the effect of parental care on offspring hippocampal volume varies as a function of parental overprotection with a large cohort of young adult participants (N = 257)...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28394902/correlation-of-hippocampal-atrophy-with-hyperhomocysteinemia-in-hemodialysis-patients-an-exploratory-pilot-study
#16
Kyoko Maesato, Takayasu Ohtake, Yasuhiro Mochida, Kunihiro Ishioka, Machiko Oka, Hidekazu Moriya, Sumi Hidaka, Shuzo Kobayashi
BACKGROUND: Cognitive impairment is one of the important critical issues in hemodialysis (HD) patients. However, the associating factors of brain atrophy in HD patients have not been fully elucidated. PURPOSE AND METHODS: Brain magnetic resonance imaging (MRI) was performed in 34 of total 72 HD outpatients in our dialysis center. These MRI images were analyzed by an application software; Voxel-based Specific Regional Analysis System for Alzheimer's Disease (VSRAD)...
2017: PloS One
https://www.readbyqxmd.com/read/28394502/the-genome-wide-expression-effects-of-escitalopram-and-its-relationship-to-neurogenesis-hippocampal-volume-and-antidepressant-response
#17
Timothy R Powell, Tytus Murphy, Simone de Jong, Sang Hyuck Lee, Katherine E Tansey, Karen Hodgson, Rudolf Uher, Jack Price, Sandrine Thuret, Gerome Breen
Antidepressant-induced hippocampal neurogenesis (AHN) is hypothesized to contribute to increases in hippocampal volume among major depressive disorder patients after long-term treatment. Furthermore, rodent studies suggest AHN may be the cellular mechanism mediating the therapeutic benefits of antidepressants. Here, we perform the first investigation of genome-wide expression changes associated with AHN in human cells. We identify gene expression networks significantly activated during AHN, and we perform gene set analyses to probe the molecular relationship between AHN, hippocampal volume, and antidepressant response...
April 10, 2017: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
https://www.readbyqxmd.com/read/28394034/the-interactive-effect-of-demographic-and-clinical-factors-on-hippocampal-volume-a-multicohort-study-on-1958-cognitively-normal-individuals
#18
Daniel Ferreira, Oskar Hansson, José Barroso, Yaiza Molina, Alejandra Machado, Juan Andrés Hernández-Cabrera, J-Sebastian Muehlboeck, Erik Stomrud, Katarina Nägga, Olof Lindberg, David Ames, Grégoria Kalpouzos, Laura Fratiglioni, Lars Bäckman, Caroline Graff, Patrizia Mecocci, Bruno Vellas, Magda Tsolaki, Iwona Kłoszewska, Hilkka Soininen, Simon Lovestone, Håkan Ahlström, Lars Lind, Elna-Marie Larsson, Lars-Olof Wahlund, Andrew Simmons, Eric Westman
Alzheimer's disease is characterized by hippocampal atrophy. Other factors also influence the hippocampal volume, but their interactive effect has not been investigated before in cognitively healthy individuals. The aim of this study is to evaluate the interactive effect of key demographic and clinical factors on hippocampal volume, in contrast to previous studies frequently investigating these factors in a separate manner. Also, to investigate how comparable the control groups from ADNI, AIBL, and AddNeuroMed are with five population-based cohorts...
February 28, 2017: Hippocampus
https://www.readbyqxmd.com/read/28391400/altered-cerebral-blood-flow-and-cerebrovascular-function-after-voluntary-exercise-in-adult-mice
#19
Lindsay S Cahill, Jonathan Bishop, Lisa M Gazdzinski, Adrienne Dorr, Bojana Stefanovic, John G Sled
The beneficial effects of physical exercise on brain health are well documented, yet how exercise modulates cerebrovascular function is not well understood. This study used continuous arterial spin labeling magnetic resonance imaging with a hypercapnic challenge to examine changes in cerebral blood flow and vascular function after voluntary exercise in healthy, adult mice. Thirty exercise mice and twenty-one control mice were imaged prior to the start of the exercise regime (at 12 weeks of age) and after 4 weeks of voluntary exercise...
April 8, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28390437/brain-structural-investigation-and-hippocampal-tractography-in-medication-overuse-headache-a-native-space-analysis
#20
M Meyer, G Di Scala, M Edde, B Dilharreguy, F Radat, M Allard, S Chanraud
BACKGROUND: Spatial normalization of brain images, a prerequisite for voxel based morphometry analysis, may account for the large variability of the volumetric data in medication overuse headache (MOH); possibly because this disease concerns patients differing on both sex and age, and hence with different brain size and shape. METHODS: The present study aimed at providing a subject-based analysis of macrostructure using a native space volumes segmentation (Freesurfer), and microstructure using a region of interest (ROI: i...
April 8, 2017: Behavioral and Brain Functions: BBF
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