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Matteo Ciocci, Egidio Iorio, Felicia Carotenuto, Haneen A Khashoggi, Francesca Nanni, Sonia Melino
The improvement of solubility and/or dissolution rate of poorly soluble natural compounds is an ideal strategy to make them optimal candidates as new potential drugs. Accordingly, the allyl sulfur compounds and omega-3 fatty acids are natural hydrophobic compounds that exhibit two important combined properties: cardiovascular protection and antitumor activity. Here, we have synthesized and characterized a novel formulation of diallyl disulfide (DADS) and α-linolenic acid (ALA) as protein-nanoemulsions (BAD-NEs), using ultrasounds...
October 12, 2016: Oncotarget
Ji Hye Park, Sung Hyun Choi, Hyungtae Kim, Seung Taek Ji, Woong Bi Jang, Jae Ho Kim, Sang Hong Baek, Sang Mo Kwon
Doxorubicin (DOXO) is widely used to treat solid tumors. However, its clinical use is limited by side effects including serious cardiotoxicity due to cardiomyocyte damage. Resident cardiac progenitor cells (hCPCs) act as key regulators of homeostasis in myocardial cells. However, little is known about the function of hCPCs in DOXO-induced cardiotoxicity. In this study, we found that DOXO-mediated hCPC toxicity is closely related to calcium-related autophagy signaling and was significantly attenuated by blocking mTOR signaling in human hCPCs...
October 9, 2016: International Journal of Molecular Sciences
Kenneth McLaughlin, Jadwiga Leigh, Aidan Worsley
In this paper, we analyse the way in which social work, as a profession, has coped with and responded to the various forms of regulation to which it has been subject in England. First, we briefly detail the rise of external regulation of the professions, discussing both the rationale for, and criticisms of, such developments. Second, we take a closer look at developments within social work and the operation of the General Social Care Council (GSCC)'s conduct proceedings from its inception in 2001 until its dissolution in 2012...
June 2016: British Journal of Social Work
Hui Cai, Fei Ye, Angelika Michel, Gwen Murphy, Shizuka Sasazuki, Philip R Taylor, You-Lin Qiao, Sue K Park, Keun-Young Yoo, Sun Ha Jee, Eo Rin Cho, Jeongseon Kim, Sheau-Chiann Chen, Christian C Abnet, Shoichiro Tsugane, Qiuyin Cai, Xiao-Ou Shu, Wei Zheng, Michael Pawlita, Meira Epplein
BACKGROUND: Incidence and mortality rates for gastric cancer, the fifth most commonly diagnosed and third most deadly cancer worldwide, are highest in East Asia. We sought to identify gastric cancer risk biomarkers among eight prospective studies from China, Japan and Korea. METHODS: This pooled nested case-control study included 1608 incident non-cardia gastric cancer cases and 1958 matched controls. Pre-diagnostic antibody levels to 15 Helicobacter pylori proteins were assessed using multiplex serology...
June 2016: International Journal of Epidemiology
Udit Agarwal, Amanda W Smith, Kristin M French, Archana V Boopathy, Alex George, David Trac, Milton E Brown, Ming Shen, Rong Jiang, Janet D Fernandez, Brian E Kogon, Kirk R Kanter, Baahaldin Alsoufi, Mary B Wagner, Manu O Platt, Michael E Davis
UNLABELLED: Children with congenital heart diseases have increased morbidity and mortality, despite various surgical treatments, therefore warranting better treatment strategies. Here we investigate the role of age of human pediatric cardiac progenitor cells (hCPCs) on ventricular remodeling in a model of juvenile heart failure. hCPCs isolated from children undergoing reconstructive surgeries were divided into 3 groups based on age: neonate (1 day to 1 month), infant (1 month to 1 year), and child (1 to 5 years)...
July 2016: Stem Cells Translational Medicine
Todd H Wagner, Rachel Willard-Grace, Ellen Chen, Thomas Bodenheimer, David H Thom
OBJECTIVES: Health coaches can help patients gain knowledge, skills, and confidence to manage their chronic conditions. Coaches may be particularly valuable in resource-poor settings, but they are not typically reimbursed by insurance, raising questions about their budgetary impact. STUDY DESIGN: The Health Coaching in Primary Care (HCPC) study was a randomized controlled trial that showed health coaches were effective at helping low-income patients improve control of their type 2 diabetes, hypertension, and/or hyperlipidemia at 12 months compared with usual care...
2016: American Journal of Managed Care
Andrea S Graham, Anita E Williams
BACKGROUND: Patient education supports general disease self-management and in relation to foot problems, it is recommended as a key intervention for people with rheumatoid arthritis (RA). Further, it is known what the foot health educational (FHE) needs are in relation to their experiences of foot problems. Podiatrists are the key health professionals who provide the management of RA-related foot pathology and this includes the delivery of FHE. However, we do not know what is currently provided and what podiatrists' perceptions are of this intervention...
2016: Journal of Foot and Ankle Research
Fabrice Ruiz, Thibault Vallet, Anne-Marie Pensé-Lhéritier, Ameziane Aoussat
OBJECTIVES: The purpose of this article was to present an original standardized tool assessing the medicine's acceptability whichever their characteristics and the patient features. METHODS: An acceptability map was built with objective measures from medicine use assessments collected in real-life conditions. Multiple correspondence analysis (MCA) was used for the mapping process. Hierarchical classification on the principal components (HCPC) of the MCA was performed for the clustering process corresponding to distinct acceptability profiles...
April 25, 2016: Journal of Pharmacy and Pharmacology
E Collett, M Marx, P Gaillard, B Roby, B Fraysse, O Deguine, P Barone
Auditory categorization involves grouping of acoustic events along one or more shared perceptual dimensions which can relate to both semantic and physical attributes. This process involves both high level cognitive processes (categorization) and low-level perceptual encoding of the acoustic signal, both of which are affected by the use of a cochlear implant (CI) device. The goal of this study was twofold: I) compare the categorization strategies of CI users and normal hearing listeners (NHL) II) investigate if any characteristics of the raw acoustic signal could explain the results...
May 2016: Hearing Research
P Gomes-Alves, M Serra, C Brito, C P Ricardo, R Cunha, M F Sousa, B Sanchez, A Bernad, M J T Carrondo, L Rodriguez-Borlado, P M Alves
Human cardiac stem/progenitor cells (hCPCs) have been shown to be capable to regenerate contractile myocardium. However, because of their relative low abundance in the heart, in vitro expansion of hCPC is mandatory to achieve necessary quantities for allogeneic or autologous cardiac regeneration therapy applications (10(6)-10(9) cells/patient). Up to now, cell number requirements of ongoing phase I/IIa trials have been fulfilled with production in static monolayer cultures. However, this manufacturing process poses critical limitations when moving to the following clinical phases where hundreds of patients will be enrolled...
May 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
(no author information available yet)
No abstract text is available yet for this article.
November 2015: Journal of Perioperative Practice
M Constanza Camargo, Kyoung-Mee Kim, Keitaro Matsuo, Javier Torres, Linda M Liao, Douglas R Morgan, Angelika Michel, Tim Waterboer, Jovanny Zabaleta, Ricardo L Dominguez, Yasushi Yatabe, Sung Kim, Erick R Rocha-Guevara, Jolanta Lissowska, Michael Pawlita, Charles S Rabkin
BACKGROUND: Helicobacter pylori is the primary cause of gastric cancer, but about 9% of cases harbor Epstein-Barr virus (EBV) in the tumor cells. There is limited evidence on the possible interaction or antagonism between these infectious agents in gastric carcinogenesis. METHODS: We compared H. pylori serologic profiles of EBV-positive (n = 58) and EBV-negative (n = 111) noncardia gastric cancer patients from the United States National Cancer Institute's International EBV-Gastric Cancer Consortium...
April 2016: Helicobacter
Pedro L Sánchez, M Eugenia Fernández-Santos, Salvatore Costanza, Andreu M Climent, Isabel Moscoso, M Angeles Gonzalez-Nicolas, Ricardo Sanz-Ruiz, Hugo Rodríguez, Stefan M Kren, Gregorio Garrido, Jose L Escalante, Javier Bermejo, Jaime Elizaga, Javier Menarguez, Raquel Yotti, Candelas Pérez del Villar, M Angeles Espinosa, María S Guillem, James T Willerson, Antonio Bernad, Rafael Matesanz, Doris A Taylor, Francisco Fernández-Avilés
The best definitive treatment option for end-stage heart failure currently is transplantation, which is limited by donor availability and immunorejection. Generating an autologous bioartificial heart could overcome these limitations. Here, we have decellularized a human heart, preserving its 3-dimensional architecture and vascularity, and recellularized the decellularized extracellular matrix (dECM). We decellularized 39 human hearts with sodium-dodecyl-sulfate for 4-8 days. Cell removal and architectural integrity were determined anatomically, functionally, and histologically...
August 2015: Biomaterials
Kaitlen Samse, Jacqueline Emathinger, Nirmala Hariharan, Pearl Quijada, Kelli Ilves, Mirko Völkers, Lucia Ormachea, Andrea De La Torre, Amabel M Orogo, Roberto Alvarez, Shabana Din, Sadia Mohsin, Megan Monsanto, Kimberlee M Fischer, Walter P Dembitsky, Åsa B Gustafsson, Mark A Sussman
Human cardiac progenitor cells (hCPC) improve heart function after autologous transfer in heart failure patients. Regenerative potential of hCPCs is severely limited with age, requiring genetic modification to enhance therapeutic potential. A legacy of work from our laboratory with Pim1 kinase reveals effects on proliferation, survival, metabolism, and rejuvenation of hCPCs in vitro and in vivo. We demonstrate that subcellular targeting of Pim1 bolsters the distinct cardioprotective effects of this kinase in hCPCs to increase proliferation and survival, and antagonize cellular senescence...
May 29, 2015: Journal of Biological Chemistry
Gwen Murphy, Neal D Freedman, Angelika Michel, Jin-Hu Fan, Philip R Taylor, Michael Pawlita, You-Lin Qiao, Han Zhang, Kai Yu, Christian C Abnet, Sanford M Dawsey
Helicobacter pylori (H. pylori) infection is the strongest known risk factor for gastric noncardia adenocarcinoma (GNCA). We used multiplex serology to determine whether seropositivity to 15 H. pylori proteins is associated with the subsequent development of noncardia gastric cancer in Linxian, China. We included 448 GNCA cases and 1242 controls from two time points within the Linxian General Population Nutrition Intervention Trial, Linxian. H. pylori multiplex seropositivity was defined as positivity to ≥4 of the 15 included antigens...
October 15, 2015: International Journal of Cancer. Journal International du Cancer
Wahid Boukouaci, Laura Lauden, Johan Siewiera, Noemie Dam, Hocine-Rachid Hocine, Zena Khaznadar, Ryad Tamouza, Luis R Borlado, Dominique Charron, Nabila Jabrane-Ferrat, Reem Al-Daccak
AIMS: Allogeneic human cardiac-derived stem/progenitor cells (hCPC) are promising candidates for cardiac repair. They interact with T cells, major effectors of the adaptive immune response, inducing 'paracrine' anti-inflammatory effects that could sustain tissue repair/regeneration. Natural killer (NK) cells are major effectors of the innate immune system that might influence the persistence of therapeutic stem/progenitor cells. Therefore, to get through successful clinical translation and anticipate allogeneic hCPC persistence, we defined their crosstalk with NK cells under steady state and inflammatory conditions...
November 1, 2014: Cardiovascular Research
(no author information available yet)
No abstract text is available yet for this article.
July 2014: Journal of Perioperative Practice
Angelika Michel, Michael Pawlita, Heiner Boeing, Lutz Gissmann, Tim Waterboer
BACKGROUND: Helicobacter pylori infection that is usually acquired in childhood and lasts for lifetime is mostly asymptomatic but associated with severe gastrointestinal disease including cancer. During chronic infection, the gastric mucosa is histologically changing. This forces H. pylori to permanent adaptation in its gastric habitat by expression of different proteins which might be reflected in distinctive antibody patterns. METHODS: To characterize dynamics of the immune response to H...
2014: Gut Pathogens
Olga Kryukov, Emil Ruvinov, Smadar Cohen
The therapeutic application of autologous cardiac-derived progenitor cells (CPCs) requires a large cell quantity generated under defined conditions. Herein, we investigated the applicability of a three-dimensional (3D) perfusion cultivation system to facilitate the expansion of CPCs harvested from human heart biopsies and characterized by a relatively high percentage of c-kit(+) cells. The cells were seeded in macroporous alginate scaffolds and after cultivation for 7 days under static conditions, some of the constructs were transferred into a perfusion bioreactor, which was operated for an additional 14 days...
November 2014: Tissue Engineering. Part C, Methods
Nicola Marinelli, Sara Fabbrizzi, Veronica Alampi Sottini, Sandro Sacchelli, Iacopo Bernetti, Silvio Menghini
The aim of the study is the elicitation of the consumer's semantic perception of different alcoholic beverages in order to provide information for the definition of communication strategies for both the private sector (and specifically the wine industry) and the public decision maker. Such information can be seen as the basis of a wider social marketing construct aimed at the promotion of responsible drinking among young consumers. The semantic differential approach was used in this study. The data collection was based on a survey to 430 consumers between 18 and 35years old in Tuscany, Italy...
April 2014: Appetite
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