keyword
MENU ▼
Read by QxMD icon Read
search

Photodynamic diagnosis

keyword
https://www.readbyqxmd.com/read/29771486/phosphorescent-starburst-pt-ii-porphyrins-as-bifunctional-therapeutic-agents-for-tumor-hypoxia-imaging-and-photodynamic-therapy
#1
Zhuang Lv, Liang Zou, Huanjie Wei, Shujuan Liu, Wei Huang, Qiang Zhao
It is very meaningful to develop bifunctional therapeutic agents which can monitor the tumor hypoxia in real time as well as maintain good photodynamic therapy (PDT) effect under hypoxia. To achieve it, herein, a series of hydrophilic phosphorescent starburst Pt(II) porphyrins as bifunctional therapeutic agents for simultaneous tumor hypoxia imaging and highly efficient PDT have been rationally designed and synthesized. They have been obtained by using Pt(II) porphyrins as the functional core and cationic oligofluorenes as the arms...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29767317/successful-sequential-treatment-with-itraconazole-and-ala-pdt-for-cutaneous-granuloma-by-candida-albicans-a-case-report-and-literature-review
#2
Qing Cai, Lian-Juan Yang, Jia Chen, Hong Yang, Zhi-Qin Gao, Xiu-Li Wang
Photodynamic therapy (PDT) is a process that combines a photosensitizing drug and light and promotes phototoxic responses in target cells, mainly via oxidative damage. Antifungal photodynamic therapy has been successfully employed against Candida species, dermatophytes, and deep mycoses. We present a case of a cutaneous granuloma caused by C. albicans treated with 5-aminolevulinic acid (ALA)-PDT. A 64-year-old man presented with two plaques on his right hand and wrist for 2 years. The diagnosis was made based on histopathology, mycology, and molecular identification of paraffin-embedded tissues...
May 16, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29763715/near-infrared-light-activated-red-emitting-upconverting-nanoplatform-for-t-1-weighted-magnetic-resonance-imaging-and-photodynamic-therapy
#3
Xiang-Long Tang, Jun Wu, Ben-Lan Lin, Sheng Cui, Hong-Mei Liu, Ru-Tong Yu, Xiao-Dong Shen, Ting-Wei Wang, Wei Xia
Photodynamic therapy (PDT) has increasingly become an efficient and attractive cancer treatment modality based on reactive oxygen species (ROS) that can induce tumor death after irradiation with ultraviolet or visible light. Herein, to overcome the limited tissue penetration in traditional PDT, a novel near-infrared (NIR) light-activated NaScF4 : 40% Yb, 2% Er@CaF2 upconversion nanoparticle (rUCNP) is successfully designed and synthesized. Chlorin e6, a photosensitizer and a chelating agent for Mn2+ , is loaded into human serum albumin (HSA) that further conjugates onto rUCNPs...
May 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29763511/a-review-of-non-invasive-imaging-in-extramammary-paget-s-disease
#4
REVIEW
Claire-Audrey Y Bayan, Trisha Khanna, Veronica Rotemberg, Faramarz H Samie, Nathalie C Zeitouni
Extramammary Paget's Disease (EMPD) is a rare intraepithelial adenocarcinoma that classically manifests with pruritic, erythematous, scaling plaques. The clinical picture frequently mimics inflammatory or infectious conditions, and is thus commonly misdiagnosed. The assessment of tumor margins is equally challenging as tumors have a propensity to spread beyond clinically visible boundaries. Appropriate non-invasive diagnostic tools can assist in the early detection, diagnosis, and management of EMPD. This paper will review the literature on non-invasive imaging modalities used in EMPD...
May 15, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29748611/light-driven-transformable-optical-agent-with-adaptive-functions-for-boosting-cancer-surgery-outcomes
#5
Ji Qi, Chao Chen, Xiaoyan Zhang, Xianglong Hu, Shenglu Ji, Ryan T K Kwok, Jacky W Y Lam, Dan Ding, Ben Zhong Tang
Fluorescence and photoacoustic imaging have different advantages in cancer diagnosis; however, combining effects in one agent normally requires a trade-off as the mechanisms interfere. Here, based on rational molecular design, we introduce a smart organic nanoparticle whose absorbed excitation energy can be photo-switched to the pathway of thermal deactivation for photoacoustic imaging, or to allow opposed routes for fluorescence imaging and photodynamic therapy. The molecule is made of a dithienylethene (DTE) core with two surrounding 2-(1-(4-(1,2,2-triphenylvinyl)phenyl)ethylidene)malononitrile (TPECM) units (DTE-TPECM)...
May 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/29744554/-current-and-established-diagnostic-modalities-for-bladder-cancer
#6
REVIEW
D Zaak, C Ohlmann, A Stenzl
INTRODUCTION: In this paper, current guidelines regarding diagnostic and staging modalities of urothelial cancer of the bladder are summarized and an overview of endoscopic, imaging, and molecular methods currently being tested are outlined. METHODS: Relevant passages from current guidelines and recent literature as well as to a certain extent our own research are examined. RESULTS: Over the last decade, imaging mainly in the form of photodynamic diagnosis (PDD) has undergone further development and found its way into several guidelines...
May 9, 2018: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/29742173/photodynamic-diagnosis-with-methyl-5-aminolevulinate-in-squamous-intraepithelial-lesions-of-the-vulva-experimental-research
#7
Lea Leufflen, Aurelie Francois, Julia Salleron, Catherine Barlier, Gilles Dolivet, Frederic Marchal, Lina Bezdetnaya
The incidence of the High-grade Squamous Intraepithelial Lesion of the vulva, formerly vulvar intra-epithelial neoplasia is progressively increasing. Today, an early detection and a precise localization of vulvar lesions are still problematic issues, due to the lack of accuracy of the available diagnostic tool. A new approach is the photodynamic diagnosis based on the fluorescence detection of protoporphyrin IX (PpIX) in cancer cells after topical application of a cream of methyl amino-levulinic acid. This study aimed to evaluate the effectiveness of photodiagnosis in order to discriminate the intensity of PpIX fluorescence between vulvar tumor and healthy skin...
2018: PloS One
https://www.readbyqxmd.com/read/29733571/aggregation-induced-emission-aie-dots-emerging-theranostic-nanolights
#8
Guangxue Feng, Bin Liu
Theranostic nanolights refer to luminescent nanoparticles possessing both imaging and therapeutic functions. Their shape, size, surface functions, and optical properties can be precisely manipulated through integrated efforts of chemistry, materials, and nanotechnology for customized applications. When localized photons are used to activate both imaging and therapeutic functions such as photodynamic or photothermal therapy, these theranostic nanolights increase treatment efficacy with minimized damage to surrounding healthy tissues, which represents a promising noninvasive nanomedicine as compared to conventional theranostic approaches...
May 7, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29732096/nanobubble-embedded-inorganic-808-nm-excited-upconversion-nanocomposites-for-tumor-multiple-imaging-and-treatment
#9
Ming-Hsien Chan, Yu-Ting Pan, Yung-Chieh Chan, Michael Hsiao, Chung-Hsuan Chen, Lingdong Sun, Ru-Shi Liu
Contrast reagents for ultrasound imaging are widely used in clinical medical diagnosis because ultrasound resolution is limited. Contrast agents must be utilized to enhance the image resolution. At present, microbubbles (MBs) and nanobubbles (NBs) are the main contrast reagent candidates for improving the signal resolution. Fluorescence upconversion nanoparticles provide high sensitivity and also function as nanocarriers. This can label tumor cells in a specific organ under irradiation of near-infrared (NIR) light...
March 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29725946/spectrophotometric-photodynamic-diagnosis-of-prostate-cancer-cells-excreted-in-voided-urine-using-5-aminolevulinic-acid
#10
Yasushi Nakai, Makito Miyake, Satoshi Anai, Shunta Hori, Yoshihiro Tatsumi, Yosuke Morizawa, Sayuri Onisi, Nobumichi Tanaka, Kiyohide Fujimoto
To evaluate the feasibility of photodynamic diagnosis using 5-aminolevulinic acid (PDD-ALA) for detection of prostate cancer (PCa) cells in urine samples after prostate massage in patients who were suspected to have PCa. One hundred and eighty-nine patients with abnormal digital rectal examination and/or an elevated prostate-specific antigen (PSA) level who underwent initial prostate biopsy were recruited. After prostate massage, the first 60 mL of voided urine was collected. For PDD-ALA, 50 mL was used. The rest of collected urine was used for polymerase chain reaction (PCR) of PSA and glyceraldehyde 3-phosphate dehydrogenase (GAPDH)...
May 4, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29725730/facile-one-pot-synthesis-of-multifunctional-polyphosphazene-nanoparticles-as-multifunctional-platform-for-tumor-imaging
#11
Zongfang Wang, Min Hu, Shugang Hu, Jia Han, Zhenzhen Wang, Yanke Chen, Cheng Huang, Lei Fu, Zhenxi Zhang
By integrating imaging and drug-delivery in a single system, fluorescent nano-multifunctional imaging platforms can offer simultaneous diagnosis and therapy to diseases like cancer. However, the synthesis of such system involves a tedious, time-consuming, and multi-step process. Herein we report a facile method based on simple ultrasonication to synthesize highly cross-linked, monodispersed fluorescent polyphosphazene nanoparticles from hexachlorocyclotriphosphazene (HCCP) and dichlorofluorescein (FD). Various functional groups (folic acid, PEG-NH2 , and methylene blue) can be "fastened" in situ onto the poly(cyclotriphosphazene-co-dichlorofluorescein) (PCTPDF) nanoparticles to expand its application as nano-multifunctional platform...
May 3, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29719692/photosensitizer-synergistic-effects-d-a-d-structured-organic-molecule-with-enhanced-fluorescence-and-singlet-oxygen-quantum-yield-for-photodynamic-therapy
#12
Jianhua Zou, Zhihui Yin, Peng Wang, Dapeng Chen, Jinjun Shao, Qi Zhang, Liguo Sun, Wei Huang, Xiaochen Dong
The development of photosensitizers with high fluorescence intensity and singlet oxygen (1 O2 ) quantum yields (QYs) is of great importance for cancer diagnosis and photodynamic therapy (PDT). Diketopyrrolopyrrole (DPP) and boron dipyrromethene (BODIPY) are two kinds of building block with great potential for PDT. Herein, a novel donor-acceptor-donor (D-A-D) structured organic photosensitizer DPPBDPI with a benzene ring as a π bridge linking DPP and BODIPY has been designed and synthesized. The results indicate that the combination of DPP with BODIPY can simultaneously increase the fluorescence QY (5...
February 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29683282/photodynamic-therapy-as-an-alternative-treatment-for-mycosis-fungoides-a-systemic-review-and-meta-analysis
#13
S Morteza Seyed Jafari, Simone Cazzaniga, Robert E Hunger
Mycosis fungoides is the most common Cutaneous T cell lymphoma. Selection of appropriate treatment for mycosis fungoides is based on prognostic factors and overall clinical stage at diagnosis. In the past decade, clinical success has been reported using photodynamic therapy as an alternative target-specific therapy to treat mycosis fungoides. This review aimed to summarize the current advances in management of mycosis fungoides by administration of photodynamic therapy.
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29664602/engineering-persistent-luminescence-nanoparticles-for-biological-applications-from-biosensing-bioimaging-to-theranostics
#14
Shao-Kai Sun, He-Fang Wang, Xiu-Ping Yan
Persistent luminescence nanoparticles (PLNPs) are unique optical materials emitting long-lasting luminescence after ceasing excitation. Such a unique optical feature allows luminescence detection without constant external illumination to avoid the interferences of autofluorescence and scattering light from biological fluids and tissues. Besides, near-infrared (NIR) PLNPs have advantages of deep penetration and the reactivation of the persistent luminescence (PL) by red or NIR light. These features make the application of NIR-emitting PLNPs in long-term bioimaging no longer limited by the lifetime of PL...
April 17, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29662543/optical-improvements-in-the-diagnosis-of-bladder-cancer-implications-for-clinical-practice
#15
REVIEW
Tina Schubert, Steffen Rausch, Omar Fahmy, Georgios Gakis, Arnulf Stenzl
Background: For over 100 years white-light cystoscopy has remained the gold-standard technique for the detection of bladder cancer (BCa). Some limitations in the detection of flat lesions (CIS), the differentiation between inflammation and malignancy, the inaccurate determination of the tumor margin status as well as the tumor depth, have led to a variety of technological improvements. The aim of this review is to evaluate the impact of these improvements in the diagnosis of BCa and their effectiveness in clinical practice...
November 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/29656069/-microscopic-peritoneal-metastases-of-epithelial-ovarian-cancers-clinical-relevance-diagnostic-and-therapeutic-tools
#16
Y Kerbage, G Canlorbe, J P Estevez, A Grabarz, S Mordon, C Uzan, P Collinet, H Azaïs
Understanding the biology and progression mechanisms of peritoneal metastases in ovarian epithelial cancers (EOC) is important because peritoneal carcinomatosis is present or will occur during surveillance of a majority of patients. Despite the clinical remission achieved after complete macroscopic cytoreductive surgery and platinum-based chemotherapy, 60% of patients will develop peritoneal recurrence. This suggests that microscopic lesions, which are not eradicated by surgery may be present and may participate in the mechanisms leading to peritoneal recurrence...
April 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29650943/-a-useful-case-of-photodynamic-diagnosis-of-inferior-vena-cava-invasion-by-pancreatic-head-cancer-using-5-aminolevulinic-acid-5-ala
#17
Toru Mizutani, Yasutoshi Murayama, Hisashi Ikoma, Tomohiro Arita, Toshiyuki Kosuga, Hirotaka Konishi, Ryo Morimura, Atsushi Shiozaki, Yoshiaki Kuriu, Masayoshi Nakanishi, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
Curative resection is necessary to survival in pancreatic cancer, however after surgery, pathologic examination sometimes diagnoses the remains of cancer at the resected stump. Therefore, it is necessary to evaluate the stump by intraoperative rapid pathological examination. 5-aminolevulinic acid(5-ALA)is an endogenous natural amino acid and precursor of the heme pathway. 5-ALA is metabolized and accumulated as protoporphyrin IX(Pp IX)that is photosensitive substance. 5-ALA mediated photodynamic diagnosis(PDD)(ALA-PDD)has high diagnostic ability...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29623251/central-serous-chorioretinopathy-with-angioid-streaks-a-rare-combination
#18
Ambreen Sarmad, Fadi Alfaqawi, Monali Chakrabarti, Samer Elsherbiny
Purpose: This rare case shows the presence of both angioid streaks (AS) and central serous chorioretinopathy (CSC) in the same eye. Methods: A 41-year-old Caucasian male who also has a positive family history of AS was diagnosed with angioid streaks. He was followed for few years, later developed CSC in his good eye. Results: Fundus fluorescein led to the diagnosis of CSC and indocyanine green angiography ruled out the possibility of idiopathic polypoidal choroidal vasculopathy (IPCV). The CSC followed a chronic course of non-resolution and finally half fluence photodynamic therapy was performed...
2018: GMS Ophthalmology Cases
https://www.readbyqxmd.com/read/29619546/clinical-application-of-photodynamic-medicine-technology-using-light-emitting-fluorescence-imaging-based-on-a-specialized-luminous-source
#19
REVIEW
Tsutomu Namikawa, Kazune Fujisawa, Eri Munekage, Jun Iwabu, Sunao Uemura, Shigehiro Tsujii, Hiromichi Maeda, Hiroyuki Kitagawa, Hideo Fukuhara, Keiji Inoue, Takayuki Sato, Michiya Kobayashi, Kazuhiro Hanazaki
The natural amino acid 5-aminolevulinic acid (ALA) is a protoporphyrin IX (PpIX) precursor and a new-generation photosensitive substance that accumulates specifically in cancer cells. When indocyanine green (ICG) is irradiated with near-infrared (NIR) light, it shifts to a higher energy state and emits infrared light with a longer wavelength than the irradiated NIR light. Photodynamic diagnosis (PDD) using ALA and ICG-based NIR fluorescence imaging has emerged as a new diagnostic technique. Specifically, in laparoscopic examinations for serosa-invading advanced gastric cancer, peritoneal metastases could be detected by ALA-PDD, but not by conventional visible-light imaging...
April 4, 2018: Medical Molecular Morphology
https://www.readbyqxmd.com/read/29615769/simultaneous-monitoring-of-cell-surface-receptor-and-tumor-targeted-photodynamic-therapy-via-tdt-initiated-poly-g-quadruplexes
#20
Tianhui Shi, Menglin Wang, Hao Li, Miao Wang, Xingyu Luo, Yan Huang, Hong-Hui Wang, Zhou Nie, Shouzhuo Yao
Cancer cells contain a unique set of cell surface receptors that provide potential targets for tumor theranostics. Here, we propose an efficient approach to construct G-quadruplex-based aptamers that specifically recognize cell-surface receptors and monitor them in an amplified manner. This designed aptamer combined particular sequence for the c-Met on the cell surface and poly-G-quadruplexes structures that allow a rapid and amplified fluorescent readout upon the binding of thioflavin T (ThT). The poly-G-quadruplexes also function as a carrier for photosensitizers such as TMPyP4 in that, the aptamer further trigger the production of reactive oxygen species (ROS) to commit cells to death...
April 3, 2018: Scientific Reports
keyword
keyword
71357
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"