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Photodynamic diagnosis

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https://www.readbyqxmd.com/read/28095557/the-photodynamic-therapy-experience-of-a-high-volume-laser-and-dermatologic-surgery-center
#1
David E Orbuch, Lauren Penn, Bradley S Bloom, Jeremy A Brauer, Daniel B Shin, Joshua Greenbaum, Leonard J Bernstein, Elliot T Weiss, Robert T Anolik, Roy G Geronemus
BACKGROUND: Photodynamic therapy (PDT) is an FDA approved treatment for actinic keratoses (AK's) although multiple off-label indi- cations are reported. Despite frequent use for AK's, no clear consensus exists regarding protocols for overall treatment parameters. METHODS: Retrospective chart review of 1,491 subjects who underwent PDT between 2007 and 2011 at a high volume laser surgery center. Demographic information, clinical history, treatment data, and subsequent diagnosis of skin cancers were recorded...
November 1, 2016: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28075057/two-dimensional-nanomaterials-for-cancer-nanotheranostics
#2
Yongjiu Chen, Yakun Wu, Bingbing Sun, Sijin Liu, Huiyu Liu
Emerging nanotechnologies show unprecedented advantages in accelerating cancer theranostics. Among them, two-dimensional nanomaterials (2DNMs) represent a novel type of material with versatile physicochemical properties that have enabled a new horizon for applications in both cancer diagnosis and therapy. Studies have demonstrated that 2DNMs may be used in diverse aspects, including i) cancer detection due to their high propensity towards tumor markers; ii) molecular imaging for guided tumor therapies, and iii) drug and gene loading, photothermal and photodynamic cancer therapies...
January 11, 2017: Small
https://www.readbyqxmd.com/read/28062929/epidemiology-treatment-pattern-and-health-care-utilization-of-myopic-choroidal-neovascularization-a-population-based-study
#3
Ming-Chin Yang, Yen-Po Chen, Elise Chia-Hui Tan, Claudia Leteneux, Erin Chang, Carol Hy Chu, Chi-Chun Lai
PURPOSE: To investigate the prevalence and incidence of myopic choroidal neovascularization (CNV) in Taiwan, including the health care utilization and treatment-associated costs. METHODS: A retrospective cohort study using existing data from the Taiwanese National Health Insurance claims database to identify patients who had a diagnosis of myopic CNV recorded from 1 January 2009 to 31 December 2011. The prevalence of myopic CNV was monitored during this period, and the frequency and cost of both treatment visits and monitoring visits were analyzed for 2 years following diagnosis...
January 6, 2017: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28031709/magnetic-and-fluorescent-gd2o3-yb-3-ln-3-nanoparticles-for-simultaneous-upconversion-luminescence-mr-dual-modal-imaging-and-nir-induced-photodynamic-therapy
#4
Jun Liu, Long Huang, Xiumei Tian, Xiaoming Chen, Yuanzhi Shao, Fukang Xie, Dihu Chen, Li Li
The development of upconversion nanoparticles (UCNs) for theranostics application is a new strategy toward the accurate diagnosis and efficient treatment of cancer. Here, magnetic and fluorescent lanthanide-doped gadolinium oxide (Gd2O3) UCNs with bright upconversion luminescence (UCL) and high longitudinal relaxivity (r1) are used for simultaneous magnetic resonance imaging (MRI)/UCL dual-modal imaging and photodynamic therapy (PDT). In vitro and in vivo MRI studies show that these products can serve as good MRI contrast agents...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27943650/modern-trends-in-biophotonics-for-clinical-diagnosis-and-therapy-to-solve-unmet-clinical-needs
#5
Christoph Krafft
This contribution covers recent original research papers in the biophotonics field. The content is organized into main techniques such as multiphoton microscopy, Raman spectroscopy, infrared spectroscopy, optical coherence tomography and photoacoustic tomography, and their applications in the context of fluid, cell, tissue and skin diagnostics. Special attention is paid to vascular and blood flow diagnostics, photothermal and photodynamic therapy, tissue therapy, cell characterization, and biosensors for biomarker detection...
December 2016: Journal of Biophotonics
https://www.readbyqxmd.com/read/27941379/can-we-improve-transurethral-resection-of-the-bladder-tumour-for-nonmuscle-invasive-bladder-cancer
#6
Esmee Iml Liem, Theo M de Reijke
PURPOSE OF REVIEW: The recurrence rate in patients with nonmuscle invasive bladder cancer is high, and the quality of transurethral resection of the bladder (TURB) tumour influences recurrence risk. We review new methods that aim to improve the effectiveness of TURB, and highlight studies of the past year. RECENT FINDINGS: Several approaches have been explored: bipolar resection is well tolerated and efficient; however, surgical outcomes are not clearly superior to monopolar resection; en-bloc resection seems feasible and well tolerated, and has the potential to improve the quality of tissue for histopathology; enhancement techniques such as photodynamic diagnosis, narrow band imaging, and Image1 S improve tumour detection, whereas photodynamic diagnosis reduces recurrence rates; high-resolution imaging modality such as confocal laser endomicroscopy may provide histopathologic information...
December 9, 2016: Current Opinion in Urology
https://www.readbyqxmd.com/read/27904858/interventional-therapy-of-esophageal-cancer
#7
REVIEW
Aiwu Mao
Esophageal cancer (EC) is the fourth leading cause of cancer death in China. Despite a lot of advances in diagnosis and therapy, the survival rate of patients with EC is low. There is urgent need for a variety of methods and techniques to improve the survival time and alleviate the lesions of EC. Nowadays, alternative and less invasive approaches to the treatment of ECs are being identified. Here, we review several main interventional methods at different stages of EC, including endoscopic resection, stent placement, arterial infusion, photodynamic therapy, and radiofrequency ablation...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27894979/comparison-of-white-light-photodynamic-diagnosis-and-narrow-band-imaging-in-detection-of-carcinoma-in-situ-or-flat-dysplasia-at-transurethral-resection-of-the-bladder-the-dablaca-8-study
#8
Ditte Drejer, Sami Béji, Recep Oezeke, Anna Munk Nielsen, Søren Høyer, Truls Erik Bjerklund Johansen, Gitte W Lam, Jørgen B Jensen
OBJECTIVE: To compare findings in NBI to findings in WL and PDD in a high-risk patient population. MATERIALS AND METHODS: A total of 171 patients were included in the study from 4 different urology departments in Denmark and Norway. Patients were scheduled for a PDD-guided transurethral tumor resection or cystoscopy-guided biopsy in accordance with Danish guidelines, on the suspicion of primary or concomitant CIS. All patients were examined with WL cystoscopy followed by both NBI and PDD before biopsy...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27871684/the-utility-of-5-aminolevulinic-acid-mediated-photodynamic-diagnosis-in-the-detection-of-intraoperative-bile-leakage
#9
Yoshihiro Inoue, Yoshiro Imai, Kensuke Fujii, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
PURPOSE: The purpose of this retrospective study was to evaluate the utility of the new intraoperative bile leakage test as a preventive measure of postoperative bile leakage. METHOD: 737 patients were retrospectively analyzed with respect to the management of intra- and post-operative bile leakage. RESULTS: Nine (8.3%) of 109 patients evaluated using conventional white light fluorescent imaging were recognized as having intra-operative bile leakage...
October 8, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27869697/characteristics-of-the-protoporphyrin-ix-binding-sites-on-human-serum-albumin-using-molecular-docking
#10
Leszek Sułkowski, Bartosz Pawełczak, Mariola Chudzik, Małgorzata Maciążek-Jurczyk
Human serum albumin (HSA) is the main plasma protein responsible for a distribution of drugs in the human circulatory system. The binding to HSA is one of the factors that determines both the pharmacological actions and the side effects of drugs. The derivative of heme, protoporphyrin IX (PpIX), is a hydrophobic photosensitizer widely used in photodynamic diagnosis and therapy of various malignant disorders. Using absorption and fluorescence spectroscopy, it has been demonstrated that PpIX forms complexes with HSA...
November 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27862953/dual-stimuli-responsive-nanotheranostics-for-multimodal-imaging-guided-trimodal-synergistic-therapy
#11
Shan Fang, Jing Lin, Chunxiao Li, Peng Huang, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei Fan, Daxiang Cui, Yunsheng Xu, Zhiming Li
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27859395/photodynamic-diagnosis-with-5-aminolevulinic-acid-for-intraoperative-detection-of-peritoneal-metastases-of-ovarian-cancer-a-feasibility-and-dose-finding-study
#12
Peter Hillemanns, Pauline Wimberger, Jessica Reif, Herbert Stepp, Rüdiger Klapdor
OBJECTIVE: With a prospective feasibility study, we aimed to analyse the effect of different time points for application and dosage of preoperative oral 5-aminolevulinic acid administration for photodynamic diagnosis of peritoneal metastases in ovarian cancer patients. MATERIALS AND METHODS: In this prospective cohort study patients were randomly divided into three different groups. 5-Aminolevulinic acid was orally administered 3-14 hours before surgery using a dosage of 1 mg/kg, 4-9 hours using 10 mg/kg, and 9-16 hours using 10 mg/kg, respectively...
November 16, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27857072/dormant-cancer-cells-accumulate-high-protoporphyrin-ix-levels-and-are-sensitive-to-5-aminolevulinic-acid-based-photodynamic-therapy
#13
Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka, Shun-Ichiro Ogura
Photodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to drive the production of an intracellular photosensitizer, protoporphyrin IX (PpIX), are in common clinical use. However, the tendency to accumulate PpIX is not well understood. Patients with cancer can develop recurrent metastatic disease with latency periods. This pause can be explained by cancer dormancy. Here we created uniformly sized PC-3 prostate cancer spheroids using a 3D culture plate (EZSPHERE). We demonstrated that cancer cells exhibited dormancy in a cell density-dependent manner not only in spheroids but also in 2D culture...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#14
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27843902/multimodal-imaging-of-choroidal-neovascularization-associated-with-sclerochoroidal-calcification
#15
Angela P Bessette, Arun D Singh
We report a case of a choroidal neovascular membrane (CNVM) associated with sclerochoroidal calcification (SCC). An asymptomatic, 72-year-old male was referred to our institution for yellow-white placoid retinal lesions of both eyes. B-scan ultrasonography confirmed the diagnosis of SCC, and indocyanine green angiography confirmed the presence of an associated CNVM. Due to enlargement of a hemorrhagic pigment epithelial detachment associated with the CNVM over the course of 7 months, the patient was treated with a series of bevacizumab injections followed by photodynamic therapy (PDT)...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27825687/extended-pleurectomy-decortication-based-treatment-for-advanced-stage-epithelial-mesothelioma-yielding-a-median-survival-of-nearly-three-years
#16
Joseph S Friedberg, Charles B Simone, Melissa J Culligan, Andrew R Barsky, Abigail Doucette, Sally McNulty, Stephen M Hahn, Evan Alley, Daniel H Sterman, Eli Glatstein, Keith A Cengel
BACKGROUND: The purpose of this study was to assess survival for patients with malignant pleural mesothelioma (MPM), epithelial subtype, utilizing extended pleurectomy-decortication combined with intraoperative photodynamic therapy (PDT) and adjuvant pemetrexed-based chemotherapy. METHODS: From 2005 to 2013, 90 patients underwent lung-sparing surgery and PDT for MPM. All patients had a preoperative diagnosis of epithelial subtype, of which 17 proved to be of mixed histology...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27822632/prognostic-significance-of-basing-treatment-strategy-on-the-results-of-photodynamic-diagnosis-in-advanced-gastric-cancer
#17
Yuki Ushimaru, Yoshiyuki Fujiwara, Kentaro Kishi, Keijiro Sugimura, Takeshi Omori, Jeong-Ho Moon, Yoshitomo Yanagimoto, Masayuki Ohue, Masayoshi Yasui, Hidenori Takahashi, Shogo Kobayashi, Hirofumi Akita, Norikatsu Miyoshi, Akira Tomokuni, Masato Sakon, Masahiko Yano
BACKGROUND: We have previously reported that use of a staging laparoscopy (SL) combined with photodynamic diagnosis using 5-aminolevulinic acid (ALA-SL) improves sensitivity in detecting peritoneal dissemination in gastric cancer (GC). The purpose of this study was to examine the clinical significance of basing treatment strategies on the results of ALA-SL in patients with advanced GC. PATIENTS AND METHODS: ALA-SL was performed on 113 patients with advanced GC prior to determination of their first course of treatment...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27788580/inorganic-nanoparticles-for-image-guided-therapy
#18
Hong Yeol Yoon, Sangmin Jeon, Dong Gil You, Jae Hyung Park, Ick Chan Kwon, Heebeom Koo, Kwangmeyung Kim
Recently, nanotechnology has provided significant advances in biomedical applications including diagnosis and therapy. In particular, nanoparticles have emerged as valuable outcomes of nanotechnology due to their unique physicochemical properties based on size, shape, and surface properties. Among them, a large amount of research has reported imaging and therapeutic applications using inorganic nanoparticles with special properties. Inorganic nanoparticles developed for imaging and therapy contain metal (Au), metal oxide (Fe3O4, WO3, WO2...
January 18, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27780183/dome-shaped-maculopathy-enhanced-visualization-with-radial-optical-coherence-tomography-scans
#19
Joseph G Christenbury, Nopasak Phasukkijwatana, Anna Tan, K Bailey Freund, David Sarraf
PURPOSE: To describe two cases of dome-shaped macula (DSM) and serous macular detachment, the diagnosis of which was enhanced with a radial optical coherence tomography (OCT) scanning protocol. METHODS: Retrospective case series of DSM associated with serous macular detachment. Multimodal retinal imaging was performed including spectral domain OCT with a radial scan protocol and en face OCT angiography. Anatomical outcomes before and after therapy are presented...
January 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27773338/biomacromolecules-based-core-shell-architecture-toward-biomedical-applications
#20
Wei Cui, Anhe Wang, Jie Zhao, Junbai Li
Polyelectrolyte multilayer capsules have become a novel and promising class of hybrid materials with great potential since they can be applied in various areas, such as pharmaceutical sciences, biotechnology, and biomedicine. The concept of using such carriers for biology application is diagnosis and treatment of diseases for convenience, safety and specific targeting. Therefore, the development of biocompatible, biodegradable and specific characteristic nanostructure material is highly desirable. Much effort has been devoted to exploring innovative and effective techniques to fabricate such materials...
October 6, 2016: Advances in Colloid and Interface Science
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