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Photodynamic diagnosis

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https://www.readbyqxmd.com/read/27904858/interventional-therapy-of-esophageal-cancer
#1
REVIEW
Aiwu Mao
Esophageal cancer (EC) is the fourth leading cause of cancer death in China. Despite a lot of advances in diagnosis and therapy, the survival rate of patients with EC is low. There is urgent need for a variety of methods and techniques to improve the survival time and alleviate the lesions of EC. Nowadays, alternative and less invasive approaches to the treatment of ECs are being identified. Here, we review several main interventional methods at different stages of EC, including endoscopic resection, stent placement, arterial infusion, photodynamic therapy, and radiofrequency ablation...
October 2016: Gastrointestinal Tumors
https://www.readbyqxmd.com/read/27894979/-comparison-of-white-light-photodynamic-diagnosis-and-narrow-band-imaging-in-detection-of-carcinoma-in-situ-cis-or-flat-dysplasia-at-transurethral-resection-of-the-bladder-the-dablaca-8-study
#2
Ditte Drejer, Sami Béji, Recep Oezeke, Anna Munk Nielsen, Søren Høyer, Truls Erik Bjerklund Johansen, Gitte W Lam, Jørgen B Jensen
: Photodynamic diagnosis (PDD) and narrow band imaging (NBI) are two different modalities used to improve detection of tumors, carcinoma in situ (CIS) and flat dysplasia compared to white light (WL) cystoscopy. OBJECTIVES: To compare findings in NBI to findings in WL and PDD in a high risk patient population. DESIGN, SETTING, AND PARTICIPANTS: 171 patients were included in the study from four different urological departments in Denmark and Norway...
November 25, 2016: Urology
https://www.readbyqxmd.com/read/27871684/the-utility-of-5-aminolevulinic-acid-mediated-photodynamic-diagnosis-in-the-detection-of-intraoperative-bile-leakage
#3
Yoshihiro Inoue, Yoshiro Imai, Kensuke Fujii, Fumitoshi Hirokawa, Michihiro Hayashi, Kazuhisa Uchiyama
PURPOSE: The purpose of this retrospective study was to evaluate the utility of the new intraoperative bile leakage test as a preventive measure of postoperative bile leakage. METHOD: 737 patients were retrospectively analyzed with respect to the management of intra- and post-operative bile leakage. RESULTS: Nine (8.3%) of 109 patients evaluated using conventional white light fluorescent imaging were recognized as having intra-operative bile leakage...
October 8, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27869697/characteristics-of-the-protoporphyrin-ix-binding-sites-on-human-serum-albumin-using-molecular-docking
#4
Leszek Sułkowski, Bartosz Pawełczak, Mariola Chudzik, Małgorzata Maciążek-Jurczyk
Human serum albumin (HSA) is the main plasma protein responsible for a distribution of drugs in the human circulatory system. The binding to HSA is one of the factors that determines both the pharmacological actions and the side effects of drugs. The derivative of heme, protoporphyrin IX (PpIX), is a hydrophobic photosensitizer widely used in photodynamic diagnosis and therapy of various malignant disorders. Using absorption and fluorescence spectroscopy, it has been demonstrated that PpIX forms complexes with HSA...
November 17, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27862953/dual-stimuli-responsive-nanotheranostics-for-multimodal-imaging-guided-trimodal-synergistic-therapy
#5
Shan Fang, Jing Lin, Chunxiao Li, Peng Huang, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei Fan, Daxiang Cui, Yunsheng Xu, Zhiming Li
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27859395/photodynamic-diagnosis-with-5-aminolevulinic-acid-for-intraoperative-detection-of-peritoneal-metastases-of-ovarian-cancer-a-feasibility-and-dose-finding-study
#6
Peter Hillemanns, Pauline Wimberger, Jessica Reif, Herbert Stepp, Rüdiger Klapdor
OBJECTIVE: With a prospective feasibility study, we aimed to analyse the effect of different time points for application and dosage of preoperative oral 5-aminolevulinic acid administration for photodynamic diagnosis of peritoneal metastases in ovarian cancer patients. MATERIALS AND METHODS: In this prospective cohort study patients were randomly divided into three different groups. 5-Aminolevulinic acid was orally administered 3-14 hours before surgery using a dosage of 1 mg/kg, 4-9 hours using 10 mg/kg, and 9-16 hours using 10 mg/kg, respectively...
November 16, 2016: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/27857072/dormant-cancer-cells-accumulate-high-protoporphyrin-ix-levels-and-are-sensitive-to-5-aminolevulinic-acid-based-photodynamic-therapy
#7
Taku Nakayama, Shimpei Otsuka, Tatsuya Kobayashi, Hodaka Okajima, Kentaro Matsumoto, Yuichiro Hagiya, Keiji Inoue, Taro Shuin, Motowo Nakajima, Tohru Tanaka, Shun-Ichiro Ogura
Photodynamic therapy (PDT) and diagnosis (PDD) using 5-aminolevulinic acid (ALA) to drive the production of an intracellular photosensitizer, protoporphyrin IX (PpIX), are in common clinical use. However, the tendency to accumulate PpIX is not well understood. Patients with cancer can develop recurrent metastatic disease with latency periods. This pause can be explained by cancer dormancy. Here we created uniformly sized PC-3 prostate cancer spheroids using a 3D culture plate (EZSPHERE). We demonstrated that cancer cells exhibited dormancy in a cell density-dependent manner not only in spheroids but also in 2D culture...
November 18, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#8
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27843902/multimodal-imaging-of-choroidal-neovascularization-associated-with-sclerochoroidal-calcification
#9
Angela P Bessette, Arun D Singh
We report a case of a choroidal neovascular membrane (CNVM) associated with sclerochoroidal calcification (SCC). An asymptomatic, 72-year-old male was referred to our institution for yellow-white placoid retinal lesions of both eyes. B-scan ultrasonography confirmed the diagnosis of SCC, and indocyanine green angiography confirmed the presence of an associated CNVM. Due to enlargement of a hemorrhagic pigment epithelial detachment associated with the CNVM over the course of 7 months, the patient was treated with a series of bevacizumab injections followed by photodynamic therapy (PDT)...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27825687/extended-pleurectomy-decortication-based-treatment-for-advanced-stage-epithelial-mesothelioma-yielding-a-median-survival-of-nearly-three-years
#10
Joseph S Friedberg, Charles B Simone, Melissa J Culligan, Andrew R Barsky, Abigail Doucette, Sally McNulty, Stephen M Hahn, Evan Alley, Daniel H Sterman, Eli Glatstein, Keith A Cengel
BACKGROUND: The purpose of this study was to assess survival for patients with malignant pleural mesothelioma (MPM), epithelial subtype, utilizing extended pleurectomy-decortication combined with intraoperative photodynamic therapy (PDT) and adjuvant pemetrexed-based chemotherapy. METHODS: From 2005 to 2013, 90 patients underwent lung-sparing surgery and PDT for MPM. All patients had a preoperative diagnosis of epithelial subtype, of which 17 proved to be of mixed histology...
November 5, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27822632/prognostic-significance-of-basing-treatment-strategy-on-the-results-of-photodynamic-diagnosis-in-advanced-gastric-cancer
#11
Yuki Ushimaru, Yoshiyuki Fujiwara, Kentaro Kishi, Keijiro Sugimura, Takeshi Omori, Jeong-Ho Moon, Yoshitomo Yanagimoto, Masayuki Ohue, Masayoshi Yasui, Hidenori Takahashi, Shogo Kobayashi, Hirofumi Akita, Norikatsu Miyoshi, Akira Tomokuni, Masato Sakon, Masahiko Yano
BACKGROUND: We have previously reported that use of a staging laparoscopy (SL) combined with photodynamic diagnosis using 5-aminolevulinic acid (ALA-SL) improves sensitivity in detecting peritoneal dissemination in gastric cancer (GC). The purpose of this study was to examine the clinical significance of basing treatment strategies on the results of ALA-SL in patients with advanced GC. PATIENTS AND METHODS: ALA-SL was performed on 113 patients with advanced GC prior to determination of their first course of treatment...
November 7, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27788580/inorganic-nanoparticles-for-image-guided-therapy
#12
Hong Yeol Yoon, Sangmin Jeon, Dong Gil You, Jae Hyung Park, Ick Chan Kwon, Heebeom Koo, Kwangmeyung Kim
Recently, nanotechnology has provided significant advances in biomedical applications including diagnosis and therapy. Particularly, nanoparticles have been emerged as valuable outcomes of nanotechnology due to their unique physicochemical properties based on size, shape and surface properties. Among them, large amount of researches has reported imaging and therapeutic applications using inorganic nanoparticles with special properties. Inorganic nanoparticles developed for imaging and therapy contain metal (Au), metal oxide (Fe3O4, WO3, WO2...
October 27, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27780183/dome-shaped-maculopathy-enhanced-visualization-with-radial-optical-coherence-tomography-scans
#13
Joseph G Christenbury, Nopasak Phasukkijwatana, Anna Tan, K Bailey Freund, David Sarraf
PURPOSE: To describe two cases of dome-shaped macula (DSM) and serous macular detachment, the diagnosis of which was enhanced with a radial optical coherence tomography (OCT) scanning protocol. METHODS: Retrospective case series of DSM associated with serous macular detachment. Multimodal retinal imaging was performed including spectral domain OCT with a radial scan protocol and en face OCT angiography. Anatomical outcomes before and after therapy are presented...
September 30, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27773338/biomacromolecules-based-core-shell-architecture-toward-biomedical-applications
#14
Wei Cui, Anhe Wang, Jie Zhao, Junbai Li
Polyelectrolyte multilayer capsules have become a novel and promising class of hybrid materials with great potential since they can be applied in various areas, such as pharmaceutical sciences, biotechnology, and biomedicine. The concept of using such carriers for biology application is diagnosis and treatment of diseases for convenience, safety and specific targeting. Therefore, the development of biocompatible, biodegradable and specific characteristic nanostructure material is highly desirable. Much effort has been devoted to exploring innovative and effective techniques to fabricate such materials...
October 6, 2016: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/27759503/peri-implant-mucositis-and-peri-implantitis-current-understanding-of-their-diagnosis-clinical-implications-and-a-report-of-treatment-using-a-combined-therapy-approach
#15
Pier Paolo Poli, Marco CicciÃ, Mario Beretta, Carlo Maiorana
The clinical condition involving dental implants, characterized by soft tissue inflammation, bleeding, suppuration and rapid bone loss is widely known as peri implantitis. The main objective in the treatment of peri-implantis is to arrest the progression of the disease and at the same time to keep the dental implant in the mouth solving the inflammations signs of bleeding and pain. The aim of this paper is to highlight the effectiveness of the use of titanium brush and antimicrobial photodynamic therapy (aPDT) to decontaminate the implant surface, in association with regenerative procedures by means of autologous bone and demineralized bovine bone mineral (DBBM) in the treatment of peri-implantitis defects...
October 19, 2016: Journal of Oral Implantology
https://www.readbyqxmd.com/read/27722081/multifunctional-phosphorescent-conjugated-polymer-dots-for-hypoxia-imaging-and-photodynamic-therapy-of-cancer-cells
#16
Xiaobo Zhou, Hua Liang, Pengfei Jiang, Kenneth Yin Zhang, Shujuan Liu, Tianshe Yang, Qiang Zhao, Lijuan Yang, Wen Lv, Qi Yu, Wei Huang
Molecular oxygen (O2) plays a key role in many physiological processes, and becomes a toxicant to kill cells when excited to (1)O2. Intracellular O2 levels, or the degree of hypoxia, are always viewed as an indicator of cancers. Due to the highly efficient cancer therapy ability and low side effect, photodynamic therapy (PDT) becomes one of the most promising treatments for cancers. Herein, an early-stage diagnosis and therapy system is reported based on the phosphorescent conjugated polymer dots (Pdots) containing Pt(II) porphyrin as an oxygen-responsive phosphorescent group and (1)O2 photosensitizer...
February 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/27708235/a-next-generation-bifunctional-photosensitizer-with-improved-water-solubility-for-photodynamic-therapy-and-diagnosis
#17
Hirotada Nishie, Hiromi Kataoka, Shigenobu Yano, Jun-Ichi Kikuchi, Noriyuki Hayashi, Atsushi Narumi, Akihiro Nomoto, Eiji Kubota, Takashi Joh
Photodynamic therapy (PDT) exploits light interactions and photosensitizers to induce cytotoxic reactive oxygen species. Photodynamic diagnosis (PDD) uses the phenomenon of photosensitizer emitting fluorescence to distinguish some tumors from normal tissue. The standard photosensitizer used for PDD is 5-aminolevulinic acid (5-ALA), although it is not entirely satisfactory. We previously reported glucose-conjugated chlorin (G-chlorin) as a more effective photosensitizer than another widely used photosensitizer, talaporfin sodium (TS); however, G-chlorin is hydrophobic...
September 30, 2016: Oncotarget
https://www.readbyqxmd.com/read/27690242/biomimetic-hdl-nanoparticle-mediated-tumor-targeted-delivery-of-indocyanine-green-for-enhanced-photodynamic-therapy
#18
Yazhe Wang, Cheng Wang, Yang Ding, Jing Li, Min Li, Xiao Liang, Jianping Zhou, Wei Wang
Photodynamic therapy has emerged as a promising strategy for cancer treatment. To ensure the efficient delivery of a photosensitizer to tumor for anticancer effect, a safe and tumor-specific delivery system is highly desirable. Herein, we introduce a novel biomimetic nanoparticle named rHDL/ICG (rHDL/I), by loading amphiphilic near-infrared (NIR) fluorescent dye indocyanine green (ICG) into reconstituted high density lipoproteins (rHDL). In this system, rHDL can mediate photoprotection effect and receptor-guided tumor-targeting transportation of cargos into cells...
September 26, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27688469/optical-imaging-of-ionizing-radiation-from-clinical-sources
#19
Travis M Shaffer, Charles Michael Drain, Jan Grimm
Nuclear medicine uses ionizing radiation for both in vivo diagnosis and therapy. Ionizing radiation comes from a variety of sources, including x-rays, beam therapy, brachytherapy, and various injected radionuclides. Although PET and SPECT remain clinical mainstays, optical readouts of ionizing radiation offer numerous benefits and complement these standard techniques. Furthermore, for ionizing radiation sources that cannot be imaged using these standard techniques, optical imaging offers a unique imaging alternative...
November 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27671517/5-aminolevulinic-acid-in-intraoperative-photodynamic-therapy-of-bladder-cancer-results-of-multicenter-trial
#20
E V Filonenko, A D Kaprin, B Y A Alekseev, O I Apolikhin, E K Slovokhodov, V I Ivanova-Radkevich, A N Urlova
The results of multicenter prospective trial for efficacy of combined modality treatment: transurethral resection (TUR) + photodynamic therapy (PDT) with alasens for bladder cancer are represented in the article. Trials were organized by Research Institute of Organic Intermediates and Dyes and conducted according to clinical protocol approved by Ministry of Health of Russia, at the sites of leading Russian cancer clinical centers. The trial included 45 subjects with verified diagnosis of non-muscle-invasive bladder cancer...
September 23, 2016: Photodiagnosis and Photodynamic Therapy
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