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Photodynamic diagnosis

Pier Paolo Poli, Marco CicciÃ, Mario Beretta, Carlo Maiorana
The clinical condition involving dental implants, characterized by soft tissue inflammation, bleeding, suppuration and rapid bone loss is widely known as peri implantitis. The main objective in the treatment of peri-implantis is to arrest the progression of the disease and at the same time to keep the dental implant in the mouth solving the inflammations signs of bleeding and pain. The aim of this paper is to highlight the effectiveness of the use of titanium brush and antimicrobial photodynamic therapy (aPDT) to decontaminate the implant surface, in association with regenerative procedures by means of autologous bone and demineralized bovine bone mineral (DBBM) in the treatment of peri-implantitis defects...
October 19, 2016: Journal of Oral Implantology
Xiaobo Zhou, Hua Liang, Pengfei Jiang, Kenneth Yin Zhang, Shujuan Liu, Tianshe Yang, Qiang Zhao, Lijuan Yang, Wen Lv, Qi Yu, Wei Huang
Molecular oxygen (O2) plays a key role in many physiological processes, and becomes a toxicant to kill cells when excited to (1)O2. Intracellular O2 levels, or the degree of hypoxia, are always viewed as an indicator of cancers. Due to the highly efficient cancer therapy ability and low side effect, photodynamic therapy (PDT) becomes one of the most promising treatments for cancers. Herein, an early-stage diagnosis and therapy system is reported based on the phosphorescent conjugated polymer dots (Pdots) containing Pt(II) porphyrin as an oxygen-responsive phosphorescent group and (1)O2 photosensitizer...
February 2016: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Hirotada Nishie, Hiromi Kataoka, Shigenobu Yano, Jun-Ichi Kikuchi, Noriyuki Hayashi, Atsushi Narumi, Akihiro Nomoto, Eiji Kubota, Takashi Joh
Photodynamic therapy (PDT) exploits light interactions and photosensitizers to induce cytotoxic reactive oxygen species. Photodynamic diagnosis (PDD) uses the phenomenon of photosensitizer emitting fluorescence to distinguish some tumors from normal tissue. The standard photosensitizer used for PDD is 5-aminolevulinic acid (5-ALA), although it is not entirely satisfactory. We previously reported glucose-conjugated chlorin (G-chlorin) as a more effective photosensitizer than another widely used photosensitizer, talaporfin sodium (TS); however, G-chlorin is hydrophobic...
September 30, 2016: Oncotarget
Yazhe Wang, Cheng Wang, Yang Ding, Jing Li, Min Li, Xiao Liang, Jianping Zhou, Wei Wang
Photodynamic therapy has emerged as a promising strategy for cancer treatment. To ensure the efficient delivery of a photosensitizer to tumor for anticancer effect, a safe and tumor-specific delivery system is highly desirable. Herein, we introduce a novel biomimetic nanoparticle named rHDL/ICG (rHDL/I), by loading amphiphilic near-infrared (NIR) fluorescent dye indocyanine green (ICG) into reconstituted high density lipoproteins (rHDL). In this system, rHDL can mediate photoprotection effect and receptor-guided tumor-targeting transportation of cargos into cells...
September 26, 2016: Colloids and Surfaces. B, Biointerfaces
Travis Shaffer, Charles M Drain, Jan Grimm
Nuclear medicine utilizes ionizing radiation for both in vivo diagnosis and therapy. Ionizing radiation comes from a variety of sources, including X-rays, beam therapy, brachytherapy, and various injected radionuclides. While positron emission tomography and single-photon emission computed tomography remain clinical mainstays, optical readouts of ionizing radiation offer numerous benefits and complement these standard techniques. Furthermore, for ionizing radiation sources that cannot be imaged using these standard techniques, optical imaging offers a unique imaging alternative...
September 29, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
E V Filonenko, A D Kaprin, B Y A Alekseev, O I Apolikhin, E K Slovokhodov, V I Ivanova-Radkevich, A N Urlova
The results of multicenter prospective trial for efficacy of combined modality treatment: transurethral resection (TUR) + photodynamic therapy (PDT) with alasens for bladder cancer are represented in the article. Trials were organized by Research Institute of Organic Intermediates and Dyes and conducted according to clinical protocol approved by Ministry of Health of Russia, at the sites of leading Russian cancer clinical centers. The trial included 45 subjects with verified diagnosis of non-muscle-invasive bladder cancer...
September 23, 2016: Photodiagnosis and Photodynamic Therapy
Nazanin Rahmanian, Morteza Eskandani, Jaleh Barar, Yadollah Omidi
Rapid progresses in nanotechnology fields have led us to use a number of advanced nanomaterials (NMs) for engineering smart multifunctional nanoparticles (NPs)/nanosystems (NSs) for targeted diagnosis and therapy of various diseases including different types of malignancies. For the effective therapy of any type of solid tumor, the treatment modality should ideally solely target the aberrant cancerous cells/tissue with no/trivial impacts on the healthy cells. One approach to achieve such unprecedented impacts can be fulfilled through the use of seamless multimodal NPs/NSs with photoacoustic properties that can be achieved using advanced NMs such as graphene oxide (GO)...
October 6, 2016: Journal of Drug Targeting
Nikolay Pustogarov, Dmitriy Panteleev, Sergey A Goryaynov, Anastasia V Ryabova, Ekaterina Y Rybalkina, Alexander Revishchin, Alexander A Potapov, Galina Pavlova
Protoporphyrin IX (PpIX) is widely used in photodynamic diagnosis. To date, the details of molecular mechanisms underlying PpIX accumulation in malignant cells after 5-ALA administration remain unclear. The fluorescence of PpIX was studied in human glioma cells. Several cell cultures were established from glioma tumor tissue to study the differences between fluorescence-positive and fluorescence-negative human glioma tumors. The cell cultures demonstrated fluorescence profiles similar to those of source tumor tissues, which allows us to use these cultures in experimental research...
September 19, 2016: Molecular Neurobiology
O F Rabinovich, I M Rabinovich, A V Guseva
The aim of the study was to elaborate the rationale for the application of photodynamic therapy in complex treatment of patient with severe oral lichen planus. Complex clinical and laboratory examination and treatment was performed in 54 patients divided on 3 groups. Diagnosis of oral lichen planus was based on clinical, histological and immunohistochemical features. Group 1 received standard treatment, in the second group photodynamic therapy was conducted in addition to conventional treatment, patients in the third group received only photodynamic therapy...
2016: Stomatologii︠a︡
Masumi Nishimura, Yasutoshi Murayama, Kyoichi Harada, Yosuke Kamada, Ryo Morimura, Hisashi Ikoma, Daisuke Ichikawa, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
UNLABELLED: Backgtound/Aim: Since hepatocellular carcinoma (HCC) has a high recurrence rate, accurate diagnosis of its location and curative resection is important to improve survival. This study evaluated the utility of photodynamic diagnosis (PDD) using 5-aminolevulinic acid (5-ALA) for HCC. MATERIALS AND METHODS: We used two human hepatoma cell lines (HuH-7 and Hep G2). Cells were treated with 5-ALA for 4 h. 5-ALA-induced fluorescence was then examined under a fluorescence microscope...
September 2016: Anticancer Research
Ewa J Prażmo, Mirosław Kwaśny, Mariusz Łapiński, Agnieszka Mielczarek
Photodynamic therapy (PDT) consists of three elements: photosensitizer, light and oxygen. The photosensitizer has the property of selective accumulation in abnormal or infected tissues without causing any damage to the healthy cells. This innovative therapeutic method has already been successfully adapted in many fields of medicine, e.g. dermatology, gynecology, urology and cancer therapy. Dentistry is also beginning to incorporate photodisinfection for treatment of the oral cavity. The antibacterial and fungicidal properties of the photosensitizer have been used to achieve better results in root canal treatment, periodontal therapy and the eradication of candidiasis in prosthodontics...
July 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Mee-Young Ahn, Hyo-Eun Yoon, Seong-Yong Moon, Yong-Chul Kim, Jung-Hoon Yoon
Photodynamic therapy (PDT) is a therapeutic alternative for malignant tumors that uses a photosensitizer. Our group recently synthesized photosensitizer Pheophorbide a (Pa) from chlorophyll-a. The present study investigated the therapeutic effect of PDT using intratumoral administration of the synthetic photosensitizer Pa in an in vivo murine oral squamous cell carcinoma (OSCC) animal model. Pa accumulation was measured using the fluorescence spectrum and imaging in living C3H mice. Intratumoral treatment of Pa-PDT (IT Pa-PDT) significantly inhibited the growth of transplanted OSCC cells...
September 13, 2016: Oncology Research
Guangxue Feng, Bin Liu
The combination of diagnosis and therapeutics into one theranostics system has attracted great interest in life science and biomedical fields. The current theranostic platform largely relies on the integration of multiple materials with different functionalities. The all-in-one approach has the risk of high complicity with reduced reproducibility. Smart design of simple molecules born with multifunctions should represent one of the future directions in theranostics. Fluorogens with aggregation-induced emission (AIEgens) are one type of such smart materials, which have attracted increasing attentions in recent years...
September 8, 2016: Small
Rajan Saini, Nathan V Lee, Kelly Y P Liu, Catherine F Poh
Oral cancer is a global health burden with significantly poor survival, especially when the diagnosis is at its late stage. Despite advances in current treatment modalities, there has been minimal improvement in survival rates over the last five decades. The development of local recurrence, regional failure, and the formation of second primary tumors accounts for this poor outcome. For survivors, cosmetic and functional compromises resulting from treatment are often devastating. These statistics underscore the need for novel approaches in the management of this deadly disease...
September 2, 2016: Cancers
Thorsten Bach, Patrick J Bastian, Andreas Blana, Angelika Kaminsky, Stefan Keller, Thomas Knoll, Christoph Lang, Soeren Promnitz, Burkhard Ubrig, Thomas Keller, Bryan Qvick, Maximilian Burger
PURPOSE: White light cystoscopy (WLC) is the standard procedure for visualising non-muscle invasive bladder cancer (NMIBC). However, WLC can fail to detect all cancerous lesions, and outcomes with transurethral resection of the bladder differ between institutions, controlled trials, and possibly between trials and routine application. This noninterventional study assessed the benefit of hexaminolevulinate blue light cystoscopy (HALC; Hexvix(®), Ipsen Pharma GmbH, Germany) plus WLC versus WLC alone in routine use...
August 30, 2016: World Journal of Urology
Amirah Mohd Gazzali, Mathilde Lobry, Ludovic Colombeau, Samir Acherar, Henri Azaïs, Serge Mordon, Philippe Arnoux, Francis Baros, Régis Vanderesse, Céline Frochot
Folic acid is a small molecule, also known as vitamin B9. It is an essential compound involved in important biochemical processes. It is widely used as a vector for targeted treatment and diagnosis especially in cancer therapeutics. Nevertheless, not many authors address the problem of folic acid degradation. Several researchers reported their observations concerning its denaturation, but they generally only took into account one parameter (pH, temperature, light or O2etc.). In this review, we will focus on five main parameters (assessed individually or in conjunction with one or several others) that have to be taken into account to avoid the degradation of folic acid: light, temperature, concentration, oxygen and pH, which are the most cited in the literature...
October 10, 2016: European Journal of Pharmaceutical Sciences
Sławomir G Kata, Omar Aboumarzouk
INTRODUCTION: There is observed increase in detection rate of upper urinary tract urothelial cancer worldwide. This is a result of improved imaging as well as implementation of novel technologies of direct visualization of upper urinary tract. Standard techniques still remain insufficient to diagnose flat urothelial lesions. Carcinoma in situ is characterized by flat disordered proliferation of urothelial cells with marked cytologic abnormality, which occur within one cell layer as well as full thickness urothelium and therefore requires a better technology to pick up early and subtle mucosal changes...
2016: Central European Journal of Urology
A Karl, T Grimm, F Jokisch, N T Gaisa, C G Stief
INTRODUCTION: Urothelial carcinoma of the bladder is known as one of most common malignant tumors in the urogenital tract. Non-muscle invasive bladder cancer (NMIBC) in particular has a high recurrence rate and results in correspondingly high costs for the public health system. METHODS: To improve the recurrence rate and the prognosis of NMIBC the diagnosis, resection technique, adjuvant instillation therapy and exact histopathological classification of tumor lesions are indispensable...
September 2016: Der Urologe. Ausg. A
Xiaodong Liu, Guangbao Yang, Lifen Zhang, Zhuang Liu, Zhenping Cheng, Xiulin Zhu
The multifunctional nano-micelle platform holds great promise to enhance the accuracy and efficiency of cancer diagnosis and therapy. In this work, an amphiphilic poly[(poly(ethylene glycol) methyl ether methacrylate)-co-(3-aminopropyl methacrylate)]-block-poly(methyl methacrylate) (P(PEGMA-co-APMA)-b-PMMA) block copolymer was synthesized by successive RAFT polymerizations and subsequent chemical modification. Then the multifunctional micelles with high solubility in physiological environments were developed by a self-assembly and crosslinking processes...
August 18, 2016: Nanoscale
H Pye, M A Butt, H W Reinert, A Maruani, J P M Nunes, J S Marklew, M Qurashi, L Funnell, A May, I Stamati, R Hamoudi, J R Baker, M E B Smith, S Caddick, M P Deonarain, G Yahioglu, V Chudasama, L B Lovat
In many cancers early intervention involves surgical resection of small localised tumour masses. Inadequate resection leads to recurrence whereas overzealous treatment can lead to organ damage. This work describes production of a HER2 targeting antibody Fab fragment dual conjugated to achieve both real time near-infrared fluorescent imaging and photodynamic therapy. The use of fluorescence emission from a NIR-dye could be used to guide resection of tumour bulk, for example during endoscopic diagnosis for oesophago-gastric adenocarcinoma, this would then be followed by activation of the photodynamic therapeutic agent to destroy untreated localised areas of cancer infiltration and tumour infiltrated lymph nodes...
October 5, 2016: Photochemical & Photobiological Sciences
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