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Photodynamic diagnosis

Aditya Kanesa-Thasan, Amani A Fawzi, Manjot K Gill
PURPOSE: Central serous chorioretinopathy (CSC) is a disease in which serous detachment of the neurosensory retina occurs over an area of leakage from the choriocapillaris through the retinal pigment epithelium. Associations have been drawn between high-stress personality types and steroid exposure. This article aims to describe a unique case series of two husband and wife couples with CSC. METHODS: All methods were approved by the authors' institution's institutional review board...
April 2018: Retinal Cases & Brief Reports
María Pilar Ruiz-Del-Tiempo, Pilar Calvo, Antonio Ferreras, Jesús Leciñena, Luis Pablo, Oscar Ruiz-Moreno
Purpose: To evaluate anatomical retinal changes measured by spectral-domain optical coherence tomography (SD-OCT), after applying photodynamic therapy (PDT) for treatment of chronic central serous chorioretinopathy (CSC). Methods: A retrospective analysis was conducted on 43 patients (48 eyes) with chronic CSC treated with PDT. Visual acuity (VA), central retinal thickness (CRT), outer nuclear layer (ONL) thickness, subretinal fluid (SRF), and photoreceptor ellipsoid zone (EZ) measured by SD-OCT were collected at baseline and at 3, 6, and 12 months after PDT...
2018: Journal of Ophthalmology
Karen G Karakov, Kristina S Gandylyan, Emiliya E Khachaturyan, Tatyana N Vlasova, Artur V Oganyan, Alla V Eremenko
BACKGROUND: The article describes the results of research on efficiency of using antimicrobial photodynamic therapy in treatment of chronic periodontitis. METHODS: 88 root canals in 84 patients were examined and treated. The diagnosis of chronic apical periodontitis was made based on anamnesis, data of clinical and instrumental examination, assessment of X-ray images. Patients were randomly selected to comply with the purity of the experiment. RESULTS: It was found that the use of antimicrobial photodynamic therapy leads to a reduction of medical cases accompanied by pain reaction after a one-stage treatment of chronic periodontitis when compared with data of the patients treated with calcium hydroxide preparation...
February 2018: Journal of the National Medical Association
Yu-Jie Li, Cheng-Xiong Yang, Xiu-Ping Yan
Metastasis is the main cause of death in people with cancer. Early diagnosis and targeted therapy for metastasis is crucial for the survival of the cancer patients. However, metastasis is hard to trace for its small size, dispersed distribution and un-vascularized anatomy. Here we report a biomimetic persistent luminescent nanoplatform for non-invasive high-sensitive diagnosis and 808 nm laser controlled photodynamics assisted chemotherapy of metastasis. The nanoplatform is composed of a photosensitizer functionalized persistent luminescent nanoparticle core, a doxorubicin loaded hollow silica interlayer and a cancer cell membrane shell for effective metastasis theranostic...
March 5, 2018: Analytical Chemistry
Duo Mao, Fang Hu, Kenry, Shenglu Ji, Wenbo Wu, Dan Ding, Deling Kong, Bin Liu
Bacterial infection is one of the most serious physiological conditions threatening human health. There is an increasing demand for more effective bacterial diagnosis and treatment through noninvasive theranostic approaches. Herein, a new strategy is reported to achieve in vivo metabolic labeling of bacteria through the use of MIL-100 (Fe) nanoparticles (NPs) as the nanocarrier for precise delivery of 3-azido-d-alanine (d-AzAla). After intravenous injection, MIL-100 (Fe) NPs can accumulate preferentially and degrade rapidly within the high H2 O2 inflammatory environment, releasing d-AzAla in the process...
March 5, 2018: Advanced Materials
Zhipeng Li, Yifeng Wang, Cheng-Chu Zeng, Li-Ming Hu, Xing-Jie Liang
Melanoma is a highly aggressive malignancy and early monitoring and diagnosis are challenging at present. Tyrosinase is overexpressed in melanoma and regarded as an important biological marker for diagnosis and treatment. Thus, the selective and sensitive detection of tyrosinase is of great significance. To date, a few fluorescent probes have been reported for the detection of tyrosinase in vitro or in vivo. However, a highly sensitive near-infrared probe for tyrosinase monitoring is still missing. In this study, the Gibbs free energy change of different urea bonds during spontaneous hydrolysis is analysed with the aid of chemical thermodynamic computation...
March 1, 2018: Analytical Chemistry
Jane Dobson, Genilson Fernandes de Queiroz, Jon P Golding
Photodynamic therapy (PDT) is an evolving method of treating superficial tumours that is non-invasive and carries minimal risk of toxicity. It combines tumour-selective photosensitiser dyes, tissue oxygen and targeted illumination to generate cytotoxic reactive oxygen species (ROS) within the tumour. In addition to directly acting on tumour cells, PDT damages and restricts tumour microvasculature, and causes a local inflammatory response that stimulates an immune response against the tumour. Unlike surgery or radiotherapy, the surrounding extracellular matrix is unaffected by PDT; thus, tissue healing is excellent and PDT seldom causes scars...
March 2018: Veterinary Journal
Junjie Liu, Ping Xue, Jingwen Deng
BACKGROUND: Cholangiocarcinoma is a malignant neoplasia that originates in the bile ducts. Most patients with cholangiocarcinoma are inoperable at the time of diagnosis. photodynamic therapy (PDT) is a fairly well accepted treatment in clinical practice for nonresectable cholangiocarcinoma (NCC) but lack of quantitatively assessment. Herein, we present a protocol for a systematic review to identify the efficacy of PDT in patients with NCC. METHODS: We will search PUBMED, SpringerLink, Cochrane Library, the Chinese Biomedical database (CBM), WanFang data, China National Knowledge Infrastructure (CNKI) up to December 2017...
February 2018: Medicine (Baltimore)
Arif Gulzar, Jiating Xu, Dan Yang, Liangge Xu, Fei He, Shili Gai, Piaoping Yang
NIR light-induced imaging-guided cancer therapy is an encouraging route in the cancer theranostic field. Herein, we describe a novel nanoscale proposal, which is established by covalently implanting core-shell structured upconversion nanoparticles (UCNPs) with nanographene oxide (NGO) by a process utilizing polyethylene glycol (PEG), and consequently loading Chlorin e6 (Ce6) onto the surface of NGO. The acquired NGO-UCNP-Ce6 (NUC) nanocomposites can not only be employed as upconversion luminescence (UCL) imaging probes of cells and whole-body animals with high contrast for diagnosis, but also can generate reactive oxygen species (ROS) under 808 nm light excitation for photodynamic therapy (PDT); over and above, they can swiftly and proficiently translate the 808 nm photon into thermal energy for photothermal therapy (PTT)...
February 20, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Andrew Y Wang, Patrick S Yachimski
Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) are the mainstays of interventional endoscopic practice. EUS occupies a central role in the diagnosis of pancreatobiliary neoplasms and offers a platform for a wide range of direct tumor therapies. Initial steps have demonstrated the feasibility of such applications in animal models and pilot studies. Larger clinical trials and incorporation of EUS-based therapies into cooperative cancer studies might demonstrate an impact in the clinical prognosis of patients with pancreatic cancer...
February 16, 2018: Gastroenterology
Yanke Wang, Dongdong Cai, Huixia Wu, Yu Fu, Yang Cao, Yingjian Zhang, Dongmei Wu, Qiwei Tian, Shiping Yang
Multifunctional nano-biomaterials with the integration of diagnostic and therapeutic functions have shown great promise in improving the efficacy of cancer therapy. Herein, a new nanoplatform based on functionalized Cu 3 BiS 3 nanoparticles (NPs) is fabricated for tumour-targeted combination phototherapy. The as-synthesized hydrophobic Cu 3 BiS 3 NPs are modified with DSPE-PEG/DSPE-PEG-NH 2 , followed by the conjugation of the photosensitizer chlorin e6 (Ce6) and the target ligand folic acid (FA). The introduced Ce6 can further form a chelate complex with Gd 3+ ...
February 16, 2018: Nanoscale
Kazuhide Shimizu, Masayuki Nitta, Takashi Komori, Takashi Maruyama, Takayuki Yasuda, Yu Fujii, Ken Masamune, Takakazu Kawamata, Taketoshi Maehara, Yoshihiro Muragaki
Objective: The goal of this study was to demonstrate the feasibility of intraoperative photodynamic diagnosis (PDD) of malignant glioma using the fluorescence from talaporfin sodium (TS), which is used simultaneously for photodynamic therapy (PDT). Methods: Patients with suspected primary malignant glioma who were eligible for surgical removal of the tumor and PDT with TS were enrolled in this prospective study. Tissue samples were obtained from the contrast-enhanced (CE) region and from the surrounding non-contrast-enhanced (NCE) marginal tissue at the boundary between the tumor and normal tissue...
2018: Frontiers in Neurology
Ido Didi Fabian, Andrew W Stacey, Lamis Al Harby, Amit K Arora, Mandeep S Sagoo, Victoria M L Cohen
AIMS: To investigate the outcomes of primary photodynamic therapy (PDT) for pigmented posterior pole cT1a choroidal melanoma. METHODS: Retrospective interventional consecutive case series of 26 patients (26 eyes) with pigmented posterior pole cT1a choroidal melanoma, who were treated with 3 sessions of PDT and followed-up thereafter. RESULTS: Included were 11 males and 15 females that presented at a median age of 66 years (mean: 64) with transformed naevi (n=11) or suspicious lesions (n=15) with ≥3 risk factors for growth, with lipofuscin in all...
February 13, 2018: British Journal of Ophthalmology
Hiroki Kurumi, Tsutomu Kanda, Koichiro Kawaguchi, Kazuo Yashima, Hiroki Koda, Kumi Ogihara, Kayoko Matsushima, Kazuhiko Nakao, Hiroaki Saito, Yoshiyuki Fujiwara, Mitsuhiko Osaki, Futoshi Okada, Hajime Isomoto
BACKGROUND/AIM: Laser-based photodynamic endoscopic diagnosis (LPDED) is a type of endoscopic diagnosis that uses the fluorescence caused by the photochemical reaction that occurs when a fluorescent substance is irradiated by a light of a specific wavelength. Although 5-aminolevulinic acid (5-ALA) can detect early gastric cancer (EGC) during LPDED, there is an unresolved issue of the differences in fluorescence intensity among histopathological types of gastric cancer. Thus, the aim of the present study was to assess whether protoporphyrinogen oxidase (PPOX), involved in the activation of protoporphyrin IX, can affect the fluorescence intensity in EGC...
February 6, 2018: Photodiagnosis and Photodynamic Therapy
Alyona Sukhanova, Svetlana Bozrova, Pavel Sokolov, Mikhail Berestovoy, Alexander Karaulov, Igor Nabiev
Studies on the methods of nanoparticle (NP) synthesis, analysis of their characteristics, and exploration of new fields of their applications are at the forefront of modern nanotechnology. The possibility of engineering water-soluble NPs has paved the way to their use in various basic and applied biomedical researches. At present, NPs are used in diagnosis for imaging of numerous molecular markers of genetic and autoimmune diseases, malignant tumors, and many other disorders. NPs are also used for targeted delivery of drugs to tissues and organs, with controllable parameters of drug release and accumulation...
February 7, 2018: Nanoscale Research Letters
Domenico Piccolo, Dimitra Kostaki
Photodynamic therapy (PDT) with topical 5-aminolevulinic acid (ALA) or methyl aminolevulinate (MAL) has proven to be a highly effective conservative method for the treatment of actinic keratosis (AK), Bowen's disease (BD), and superficial basal cell carcinoma (sBCC). PDT is traditionally performed in association with broad-spectrum continuous-wave light sources, such as red or blue light. Recently, intense pulsed light (IPL) devices have been investigated as an alternative light source for PDT in the treatment of nonmelanoma skin cancers (NMSC)...
February 7, 2018: Biomedicines
Seigo Kimura, Toshihiko Kuroiwa, Naokado Ikeda, Naosuke Nonoguchi, Shinji Kawabata, Yoshinaga Kajimoto, Toshihisa Ishikawa
BACKGROUND: Oral 5-aminolevulinic acid (ALA) induces biosynthesis/accumulation of the natural photo-sensitizer protoporphyrin IX (PpIX) in cancer cells. ALA is used widely in photodynamic diagnosis (PDD) and therapy (PDT) during malignant glioma surgery, but few studies have examined the effects of photodynamics plus ALA on normal brain tissue in vivo. We investigated the effects of ALA-mediated PDD and PDT on normal brain tissue. METHODS: We established a rat model in which the brain surface was irradiated through the skull by light-emitting diode (635 nm) after ALA administration...
February 4, 2018: Photodiagnosis and Photodynamic Therapy
Huiting Bi, Yunlu Dai, Piaoping Yang, Jiating Xu, Dan Yang, Shili Gai, Fei He, Bin Liu, Chongna Zhong, Guanghui An, Jun Lin
Here a multifunctional nanoplatform (upconversion nanoparticles (UCNPs)-platinum(IV) (Pt(IV))-ZnFe2 O4 , denoted as UCPZ) is designed for collaborative cancer treatment, including photodynamic therapy (PDT), chemotherapy, and Fenton reaction. In the system, the UCNPs triggered by near-infrared light can convert low energy photons to high energy ones, which act as the UV-vis source to simultaneously mediate the PDT effect and Fenton's reaction of ZnFe2 O4 nanoparticles. Meanwhile, the Pt(IV) prodrugs can be reduced to high virulent Pt(II) by glutathione in the cancer cells, which can bond to DNA and inhibit the copy of DNA...
February 2, 2018: Small
Jonas G Croissant, Jeffrey I Zink, Laurence Raehm, Jean-Olivier Durand
Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm3 and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy...
January 18, 2018: Advanced Healthcare Materials
Dapeng Chen, Qianyun Tang, Jianhua Zou, Xiaoyan Yang, Wei Huang, Qi Zhang, Jinjun Shao, Xiaochen Dong
Synergistic cancer therapy is of great interest for multiple advantages, such as excellent targeting accuracy, low side effects, and enhanced therapeutic efficiency. Herein, a near-infrared photosensitizer aza-BODIPY (AB) with high singlet oxygen quantum yield (ΦΔ = 82%) is designed and synthesized. With Schiff's base obtained from condensation reaction between doxorubicin (DOX) and polyethylene glycol-benzaldehyde (PEG-CHO) as the polymer matrix, aza-BODIPY is encapsulated to afford hydrophilic nanoparticles (DAB NPs)...
January 15, 2018: Advanced Healthcare Materials
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