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Cardiac Perfusion imaging SPECT PET

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https://www.readbyqxmd.com/read/28695407/nuclear-cardiology-in-china-2017
#1
Gongshun Tang
This paper provides the current state of nuclear cardiology in China and contrasts it with the state of nuclear cardiology in the United States (US). The West China Hospital and New York-Presbyterian Hospital (NYPH) were used as representative hospitals to contrast nuclear cardiology in China and the US, respectively. In 2015, there were 101 medical cyclotrons, 774 SPECT or SPECT/CT, 240 PET/CT, and 6 PET/MR cameras in China. Most (~90%) of the nuclear cardiology studies are gated SPECT myocardial perfusion imaging (MPI), and ~10% are other types of studies including MUGA, PET/CT MPI, and viability studies...
July 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28559934/the-current-status-of-spect-or-spect-ct-in-south-korea
#2
REVIEW
Ikdong Yoo, Eun Kyoung Choi, Yong-An Chung
The first step to nuclear medicine in Korea started with introduction of the gamma camera in 1969. Although planar images with the gamma camera give important functional information, they have the limitations that result from 2-dimensional images. Single-photon emission computed tomography (SPECT) due to its 3-dimensional image acquisition is superior to earlier planar gamma imaging in image resolution and diagnostic accuracy. As demand for a hybrid functional and anatomical imaging device has increased, integrated SPECT/CT systems have been used...
June 2017: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28540215/myocardial-flow-reserve-mfr-with-positron-emission-tomography-pet-computed-tomography-ct-clinical-impact-in-diagnosis-and-prognosis
#3
REVIEW
Maria Cecilia Ziadi
In recent years, radionuclide myocardial perfusion imaging (MPI) using positron emission tomography/computed tomography (PET/CT) has emerged as a robust tool for the diagnosis, risk stratification and management of patients with known or established coronary artery disease (CAD). Cardiac PET/CT imaging affords key advantages compared to single photon emission computed tomography (SPECT) that encompass: (I) improved diagnostic accuracy; (II) decreased radiation exposure due to the utilization of short-lived radiopharmaceuticals, and importantly; (III) the ability to quantify noninvasively myocardial blood flow (MBF) in absolute terms, that is in ml per minute per gram of tissue...
April 2017: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/28493201/nuclear-cardiology-practice-in-spain
#4
Amelia Jimenez-Heffernan, Santiago Aguade-Bruix, Irene Casans-Tormo
BACKGROUND: In Spain, nuclear cardiology (NC) procedures represent the second most frequently performed studies in nuclear medicine (NM) centers. METHODS: The NC Working Group of the Spanish Society of Nuclear Medicine and Molecular Imaging invited NM departments across the country to answer an online questionnaire regarding 2014 activity. RESULTS: Data on 40,161 patients from 42 centers were collected. The responding public centers served 39% of Spain´s population...
May 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28473616/mini-review-on-cardiac-metabolic-imaging-current-imaging-modalities-and-future-perspectives
#5
Tineke van de Weijer, Elisabeth Helena Maria Paiman, Hildo J Lamb
In this review, current imaging techniques and their future perspectives in the field of cardiac metabolic imaging in humans are discussed. This includes a range of non-invasive imaging techniques allowing a detailed investigation of cardiac metabolism in health and disease. The main imaging modalities discussed are Magnetic Resonance Spectroscopy (MRS) techniques for determination of metabolite content (triglycerides, glucose, ATP, phosphocreatine and so on), MRI (for myocardial perfusion) Single Photon Emession Computed Tomography (SPECT) and Positron Emission Tomography (PET) for quantitation of perfusion and substrate uptake...
May 4, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28150111/spect-and-pet-in-ischemic-heart-failure
#6
George Angelidis, Gregory Giamouzis, Georgios Karagiannis, Javed Butler, Ioannis Tsougos, Varvara Valotassiou, George Giannakoulas, Nikolaos Dimakopoulos, Andrew Xanthopoulos, John Skoularigis, Filippos Triposkiadis, Panagiotis Georgoulias
Heart failure is a common clinical syndrome associated with significant morbidity and mortality worldwide. Ischemic heart disease is the leading cause of heart failure, at least in the industrialized countries. Proper diagnosis of the syndrome and management of patients with heart failure require anatomical and functional information obtained through various imaging modalities. Nuclear cardiology techniques play a main role in the evaluation of heart failure. Myocardial single photon emission computed tomography (SPECT) with thallium-201 or technetium-99 m labelled tracers offer valuable data regarding ventricular function, myocardial perfusion, viability, and intraventricular synchronism...
March 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28004791/free-triiodothyronine-level-correlates-with-myocardial-injury-and-prognosis-in-idiopathic-dilated-cardiomyopathy-evidence-from-cardiac-mri-and-spect-pet-imaging
#7
Wenyao Wang, Haixia Guan, Wei Fang, Kuo Zhang, A Martin Gerdes, Giorgio Iervasi, Yi-Da Tang
Thyroid dysfunction is associated with poor prognosis in heart failure, but theories of mechanisms are mainly based on animal experiments, not on human level. We aimed to explore the relation between thyroid function and myocardial injuries in idiopathic dilated cardiomyopathy (IDCM) using cardiac magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT) and positron emission tomography (PET). Myocardial fibrosis was detected by late gadolinium enhancement (LGE) MRI, and myocardial perfusion/metabolism was evaluated by (99m)Tc-MIBI SPECT /(18)F-FDG PET imaging...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27743299/subacute-cardiac-rubidium-82-positron-emission-tomography-82-rb-pet-to-assess-myocardial-area-at-risk-final-infarct-size-and-myocardial-salvage-after-stemi
#8
Adam Ali Ghotbi, Andreas Kjaer, Lars Nepper-Christensen, Kiril Aleksov Ahtarovski, Jacob Thomsen Lønborg, Niels Vejlstrup, Kasper Kyhl, Thomas Emil Christensen, Thomas Engstrøm, Henning Kelbæk, Lene Holmvang, Lia E Bang, Rasmus Sejersten Ripa, Philip Hasbak
BACKGROUND: Determining infarct size and myocardial salvage in patients with ST-segment elevation myocardial infarction (STEMI) is important when assessing the efficacy of new reperfusion strategies. We investigated whether rest (82)Rb-PET myocardial perfusion imaging can estimate area at risk, final infarct size, and myocardial salvage index when compared to cardiac SPECT and magnetic resonance (CMR). METHODS: Twelve STEMI patients were injected with (99m)Tc-Sestamibi intravenously immediate prior to reperfusion...
October 14, 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27540423/recent-advances-in-nuclear-cardiology
#9
REVIEW
Won Woo Lee
Nuclear cardiology is one of the major fields of nuclear medicine practice. Myocardial perfusion studies using single-photon emission computed tomography (SPECT) have played a crucial role in the management of coronary artery diseases. Positron emission tomography (PET) has also been considered an important tool for the assessment of myocardial viability and perfusion. However, the recent development of computed tomography (CT)/magnetic resonance imaging (MRI) technologies and growing concerns about the radiation exposure of patients remain serious challenges for nuclear cardiology...
September 2016: Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/27423088/enhanced-diagnostic-utility-achieved-by-myocardial-blood-analysis-a-meta-analysis-of-noninvasive-cardiac-imaging-in-the-detection-of-functional-coronary-artery-disease
#10
Neng Dai, Xianlin Zhang, Yi Zhang, Lei Hou, WeiMing Li, Bing Fan, TianSong Zhang, YaWei Xu
AIM: The aim of this study is to determine the diagnostic utility of 6 cardiac imaging modalities using fractional flow reserve (FFR) as the reference standard. METHODS: Studies reporting diagnostic performance of computed tomographic perfusion imaging (CTP), fractional flow reserve derived from computed tomography (FFRCT), cardiac magnetic resonance (CMR), positron emission tomography (PET), single-photon emission computed tomography (SPECT) and dobutamine stress echocardiography (DSE) for diagnosis of ischemia-causing lesions were included...
October 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27387521/quantitation-of-left-ventricular-ejection-fraction-reserve-from-early-gated-regadenoson-stress-tc-99m-high-efficiency-spect
#11
Yafim Brodov, Mathews Fish, Mathieu Rubeaux, Yuka Otaki, Heidi Gransar, Mark Lemley, Jim Gerlach, Daniel Berman, Guido Germano, Piotr Slomka
BACKGROUND: Ejection fraction (EF) reserve has been found to be a useful adjunct for identifying high risk coronary artery disease in cardiac positron emission tomography (PET). We aimed to evaluate EF reserve obtained from technetium-99m sestamibi (Tc-99m) high-efficiency (HE) SPECT. METHODS: Fifty patients (mean age 69 years) undergoing regadenoson same-day rest (8-11 mCi)/stress (32-42 mCi) Tc-99m gated HE SPECT were enrolled. Stress imaging was started 1 minute after sequential intravenous regadenoson ...
December 2016: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/27302895/assessment-of-left-ventricular-myocardial-viability-by-3-dimensional-speckle-tracking-echocardiography-in-patients-with-myocardial-infarction
#12
Hong Ran, Ping-Yang Zhang, You-Xiang Zhang, Jian-Xin Zhang, Wen-Fang Wu, Jing Dong, Xiao-Wu Ma
OBJECTIVES: To determine whether 3-dimensional (3D) speckle-tracking echocardiography could provide a new way to assess myocardial viability in patients with myocardial infarction (MI). METHODS: Forty-five patients with MI underwent routine echocardiography, 2-dimensional (2D) speckle-tracking echocardiography, and 3D speckle-tracking echocardiography. Radionuclide myocardial perfusion/metabolic imaging was used as a reference standard to define viable and nonviable myocardia...
August 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27283041/identification-of-angiogenesis-rich-viable-myocardium-using-rgd-dimer-based-spect-after-myocardial-infarction
#13
Min Su Lee, Hyun Soo Park, Byung Chul Lee, Jae Ho Jung, Jung Sun Yoo, Sang Eun Kim
Cardiac healing after myocardial ischemia is a complex biological process. Advances in understanding of wound healing response have paved the way for clinical testing of novel molecular imaging to improve clinical outcomes. A key factor for assessing myocardial viability after ischemic injury is the evaluation of angiogenesis accompanying increased expression of integrin αvβ3. Here, we describe the capability of an αvβ3 integrin-targeting SPECT agent, (99m)Tc-IDA-D-[c(RGDfK)]2, for identification of ischemic but viable myocardium, i...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27229941/highlights-lecture-eanm-2015-the-search-for-nuclear-medicine-s-superheroes
#14
Andreas Buck, Clemens Decristoforo
The EANM 2015 Annual Congress, held from October 10th to 14th in Hamburg, Germany, was outstanding in many respects. With 5550 participants, this was by far the largest European congress concerning nuclear medicine. More than 1750 scientific presentations were submitted, with more than 250 abstracts from young scientists, indicating that the future success of our discipline is fuelled by a high number of young individuals becoming involved in a multitude of scientific activities. Significant improvements have been made in molecular imaging of cancer, particularly in prostate cancer...
September 2016: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/26783000/nuclear-imaging-guidance-for-ablation-of-ventricular-arrhythmias
#15
REVIEW
John Duell, Vasken Dilsizian, Mark Smith, Wengen Chen, Timm Dickfeld
Due to an increase in the number of patients with heart failure and ventricular arrhythmias, ventricular tachycardia ablation has a growing clinical role. Long-term success rates remain suboptimal and require creating a detailed electroanatomic map during the procedure to identify fibrotic areas responsible for arrhythmias. Nuclear imaging can identify areas of abnormal myocardial perfusion, metabolism, and innervation, which all may enhance our ability to identify ablation targets, thus decreasing procedure time and improving success rates...
February 2016: Current Cardiology Reports
https://www.readbyqxmd.com/read/26477356/diagnosis-and-detection-of-myocardial-injury-in-active-cardiac-sarcoidosis-significance-of-myocardial-fatty-acid-metabolism-and-myocardial-perfusion-mismatch
#16
Mitsuru Momose, Kenji Fukushima, Chisato Kondo, Naoki Serizawa, Atsushi Suzuki, Koichiro Abe, Nobuhisa Hagiwara, Shuji Sakai
BACKGROUND: Myocardial injury can be detected more sensitively using (123)I-radioiodinated 15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP) than thallium-201 (TL). The present study investigated whether (18)F-fluorodeoxyglucose-positron emission tomography (FDG-PET) uptake as an index of active inflammation in patients with cardiac sarcoidosis (CS) is associated with BMIPP and TL findings, and whether dual single-photon emission computed tomography (SPECT) can facilitate diagnosis of CS...
2015: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/26386627/multimodality-noninvasive-imaging-for-assessing-therapeutic-effects-of-exogenously-transplanted-cell-aggregates-capable-of-angiogenesis-on-acute-myocardial-infarction
#17
Chieh-Cheng Huang, Hao-Ji Wei, Kun-Ju Lin, Wei-Wen Lin, Ching-Wen Wang, Wen-Yu Pan, Shiaw-Min Hwang, Yen Chang, Hsing-Wen Sung
Although the induction of neovascularization by cell-based approaches has demonstrated substantial potential in treating myocardial infarction (MI), the process of cell-mediated angiogenesis and its correlation with therapeutic mechanisms of cardiac repair remain elusive. In this work, three-dimensional (3D) aggregates of human umbilical vein endothelial cells (HUVECs) and cord-blood mesenchymal stem cells (cbMSCs) are constructed using a methylcellulose hydrogel system. By maximizing cell-cell and cell-ECM communications and establishing a hypoxic microenvironment in their inner cores, these cell aggregates are capable of forming widespread tubular networks together with the angiogenic marker αvβ3 integrin; they secret multiple pro-angiogenic, pro-survival, and mobilizing factors when grown on Matrigel...
December 2015: Biomaterials
https://www.readbyqxmd.com/read/26272807/clinical-utility-of-enhanced-relative-activity-recovery-on-systolic-myocardial-perfusion-spect-lessons-from-pet
#18
Danai Kitkungvan, Pimprapa Vejpongsa, Ketan P Korrane, Stefano Sdringola, K Lance Gould
UNLABELLED: SPECT and PET myocardial perfusion images show greater myocardial intensity and homogeneity in systole than diastole because of greater systolic myocardial thickness, less partial volume loss, and enhanced activity recovery. Consequently, conventional myocardial perfusion images obtained from whole cardiac cycles have lower myocardial intensity and greater heterogeneity than systolic images. Considering relative activity distribution on SPECT systolic images may add clinical utility to whole-cycle images and wall motion...
December 2015: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/26035516/cardiac-applications-of-pet
#19
REVIEW
Ismet Sarikaya
Routine use of cardiac positron emission tomography (PET) applications has been increasing but has not replaced cardiac single-photon emission computerized tomography (SPECT) studies yet. The majority of cardiac PET tracers, with the exception of fluorine-18 fluorodeoxyglucose (18F-FDG), are not widely available, as they require either an onsite cyclotron or a costly generator for their production. 18F-FDG PET imaging has high sensitivity for the detection of hibernating/viable myocardium and has replaced Tl-201 SPECT imaging in centers equipped with a PET/CT camera...
October 2015: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/25911442/stress-echocardiography-what-is-new-and-how-does-it-compare-with-myocardial-perfusion-imaging-and-other-modalities
#20
REVIEW
Marysia S Tweet, Adelaide M Arruda-Olson, Nandan S Anavekar, Patricia A Pellikka
Cardiovascular disease is a leading cause of morbidity and mortality, and noninvasive strategies to diagnose and risk stratify patients remain paramount in the evaluative process. Stress echocardiography is a well-established, versatile, real-time imaging modality with advantages including lack of radiation exposure, portability, and affordability. Innovative techniques in stress echocardiography include myocardial contrast echocardiography, deformation imaging, three-dimensional (3D) echocardiography, and assessment of coronary flow reserve...
June 2015: Current Cardiology Reports
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