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https://www.readbyqxmd.com/read/29764369/vareporter-variant-reporter-for-cancer-research-of-massive-parallel-sequencing
#1
Po-Jung Huang, Chi-Ching Lee, Ling-Ya Chiu, Kuo-Yang Huang, Yuan-Ming Yeh, Chia-Yu Yang, Cheng-Hsun Chiu, Petrus Tang
BACKGROUND: High throughput sequencing technologies have been an increasingly critical aspect of precision medicine owing to a better identification of disease targets, which contributes to improved health care cost and clinical outcomes. In particular, disease-oriented targeted enrichment sequencing is becoming a widely-accepted application for diagnostic purposes, which can interrogate known diagnostic variants as well as identify novel biomarkers from panels of entire human coding exome or disease-associated genes...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29740847/junior-doctors-perspectives-on-transfusion-education-in-australia
#2
C J Flores, B Quested, T Spigiel, A Thomson, B Saxon
BACKGROUND: Early postgraduate training is a critical period to develop skills and to influence future clinical practice. Little is known about Australian junior doctors' existing transfusion knowledge and its application in patient care. This study explored their transfusion practice education preferences, developed tools to assist their practice and assessed the usefulness of these tools. METHODS: A design-based study was conducted in two phases from April 2016 to March 2017...
May 8, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29739396/how-well-do-services-for-young-people-with-long-term-conditions-deliver-features-proposed-to-improve-transition
#3
A Colver, R Pearse, R M Watson, M Fay, T Rapley, K D Mann, A Le Couteur, J R Parr, H McConachie
BACKGROUND: For young people with long-term conditions, transition from child to adult-oriented health services is a critical period which, if not managed well, may lead to poor outcomes. There are features of transition services which guidance and research suggest improve outcomes. We studied nine such features, calling them 'proposed beneficial features': age-banded clinic; meet adult team before transfer; promotion of health self-efficacy; written transition plan; appropriate parent involvement; key worker; coordinated team; holistic life-skills training; transition manager for clinical team...
May 8, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29734319/-a-critical-analysis-of-the-degree-of-care-humanization-in-the-hospitals-of-the-provincia-romana-san-giovanni-di-dio-fatebenefratelli-fbf
#4
Flavia Verginelli, Rosaria Gallo, Annalisa Teti, Claudia Franco, Patrizia Piscioneri, Giovanni Pimpinella, Rosalia Fiore, Angela Primavera, Adriana Sorrentino, Giovanni Guglielmucci, Michele Venditti, Alberto Carbone, Mariateresa Iannuzzo, Giampiero Seroni, Pietro Civello, Maria Cardarelli, Giovanni Roberti
In the Hospitals of the Ordine della Provincia Romana San Giovanni di Dio Fatebenefratelli (FBF) (consisting of four hospitals located in three Italian regions) Patient Centeredness has always been considered a central point. In 2015, the Central Hospitals' Health Direction decided to use a check-list for the evaluation of the degree of Patient Centered Care Facilities, drawn up by the National Agency for Regional Health Services (Age.Na.S) during the 2010 Research Project "Experimentation and transfer of organizational empowerment models for evaluating and improving the quality of health services...
January 2018: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/29733488/role-of-torsional-dynamics-on-hole-and-exciton-stabilization-in-pi-stacked-assemblies-design-of-novel-rigid-torsionomers-of-a-cofacial-bifluorene
#5
Denan Wang, Maxim Ivanov, Damian Kokkin, John Loman, Jin-Zhe Cai, Rajendra Rathore, Scott Reid
Efficient exciton and charge delocalization across π-stacked assemblies is of critical importance in biological systems and functional polymeric materials. To examine the requirements for exciton and hole stabilization, we report the design, synthesis, and characterization of a novel set of cofacial bifluorene (F2) torsionomers: unhindered (model) MeF2, sterically hindered tBuF2, and cyclophane-like CF2, where fluorenes are rigidly locked in a perfect sandwich orientation via two methylene linkers. This set of carefully designed bichromophores with varied torsional rigidity and orbital overlap shows that exciton stabilization requires a perfect sandwich-like arrangement, as evidenced by excimeric-like emission only in CF2 and MeF2...
May 7, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29717635/sexual-and-gender-minority-health-in-medical-curricula-in-new-england-a-pilot-study-of-medical-student-comfort-competence-and-perception-of-curricula
#6
Nicole Sitkin Zelin, Charlotte Hastings, Brendin R Beaulieu-Jones, Caroline Scott, Ana Rodriguez-Villa, Cassandra Duarte, Christopher Calahan, Alexander J Adami
BACKGROUND: Sexual and gender minority (SGM) individuals experience high rates of harassment and discrimination when seeking healthcare, which contributes to substantial healthcare disparities. Improving physician training about gender identity, sexual orientation, and the healthcare needs of SGM patients has been identified as a critical strategy for mitigating these disparities. In 2014, the Association of American Medical Colleges (AAMC) published medical education competencies to guide undergraduate medical education on SGM topics...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29708924/can-we-still-learn-from-the-seven-countries-study
#7
Alessandro Menotti, Paolo Emilio Puddu
PURPOSE OF REVIEW: The Seven Countries Study (SCS) of Cardiovascular Diseases started midway last century and was the pioneer investigation of coronary heart disease (CHD) at international level. The 16 cohorts of middle-aged men enrolled in eight nations of seven countries allowed to show large differences of CHD incidence and mortality across different cultures, partly explained by average levels of serum cholesterol and dietary habits, that is, Western type patterns in the high-risk populations, and Mediterranean or Oriental type in Southern Europe and Japan...
April 26, 2018: Current Opinion in Lipidology
https://www.readbyqxmd.com/read/29671836/children-s-experience-of-symptoms-narratives-through-words-and-images
#8
REVIEW
Barbara M Sourkes
Children who live with a complex chronic or life-threatening illness face extraordinary challenges. Whether they are receiving disease-oriented treatment (aimed at potential cure or prolongation of life) or palliative treatment-or both concurrently-our challenge is to enhance their comfort and minimize their distress. Symptom management is thus a critical component of pediatric palliative care. Symptoms may be either physical or psychological in nature (or a confluence of both) and their effective management has a direct impact on the child's quality of life...
April 19, 2018: Children
https://www.readbyqxmd.com/read/29659359/-pneumonia-associated-with-mechanical-ventilation-update-and-recommendations-inter-societies-sadi-sati
#9
Wanda Cornistein, Ángel M Colque, María Inés Staneloni, María Monserrat Lloria, Mónica Lares, Ana Laura González, Alejandro Fernández Garcés, Edith Carbone
Representatives of the Argentine Society of Infectious Diseases (SADI) and the Argentine Society of Intensive Therapy (SATI) worked together on the development of specific recommendations for the diagnosis, treatment and prevention of ventilator-associated pneumonia (VAP). The methodology used was the analysis of the literature published in the last 15 years, complemented with the opinion of experts and local data. This document aims to offer basic tools to optimize diagnosis based on clinical and microbiological criteria, orientation in empirical and targeted antibiotic schemes, news on posology and administration of antibiotics in critical patients and to promote effective measures to reduce the risk of VAP...
2018: Medicina
https://www.readbyqxmd.com/read/29657064/-selective-left-mainstem-bronchial-intubation-in-the-neonatal-intensive-care-unit
#10
Anthony M H Ho, Michael P Flavin, Melinda L Fleming, Glenio Bitencourt Mizubuti
BACKGROUND: Selective neonatal left mainstem bronchial intubation to treat right lung disease is typically achieved with elaborate maneuvers, instrumentation and devices. This is often attributed to bronchial geometry which favors right mainstem entry of an endotracheal tube deliberately advanced beyond the carina. CASE SUMMARY: A neonate with severe bullous emphysema affecting the right lung required urgent non-ventilation of that lung. We achieved left mainstem bronchial intubation by turning the endotracheal tube 180° such that the Murphy's eye faced the left instead of the right, and simulated a left-handed intubation by slightly orientating the endotracheal tube such that its concavity faced the left instead of the right as in a conventional right-handed intubation...
April 12, 2018: Revista Brasileira de Anestesiologia
https://www.readbyqxmd.com/read/29642460/turning-the-co-production-corner-methodological-reflections-from-an-action-research-project-to-promote-lgbt-inclusion-in-care-homes-for-older-people
#11
Paul Willis, Kathryn Almack, Trish Hafford-Letchfield, Paul Simpson, Barbara Billings, Naresh Mall
Background : Older lesbian, gay, bisexual and trans (LGBT) residents are often invisible in long-term care settings. This article presents findings from a community-based action research project, which attempted to address this invisibility through co-produced research with LGBT community members. Particular Question: What conditions enable co-produced research to emerge in long-term residential care settings for older people? Aims of Project: To analyse outcomes and challenges of action-oriented, co-produced research in the given context...
April 7, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29623947/genetic-polymorphisms-of-the-mitochondrial-aldehyde-dehydrogenase-aldh2-gene-in-a-large-ethnic-hakka-population-in-southern-china
#12
Zhixiong Zhong, Jingyuan Hou, Bin Li, Qifeng Zhang, Cunren Li, Zhidong Liu, Min Yang, Wei Zhong, Pingsen Zhao
BACKGROUND Human mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a critical role in the detoxification of the ethanol metabolite acetaldehyde. The ALDH2*2 (rs671) gene variant is mainly absent among Europeans but is prevalent in populations in East Asia. The aim of this study was to investigate ALDH2*2 mutant alleles and genotype frequencies in the Hakka population of China. MATERIAL AND METHODS Between January 2016 and June 2017, 7,966 unrelated individuals were recruited into the study from the Hakka ethnic population residing in the Meizhou area of Guangdong Province, China, who provided venous blood samples...
April 6, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29605047/biological-origins-of-sexual-orientation-and-gender-identity-impact-on-health
#13
REVIEW
Katherine A O'Hanlan, Jennifer C Gordon, Mackenzie W Sullivan
Gynecologic Oncologists are sometimes consulted to care for patients who present with diverse gender identities or sexual orientations. Clinicians can create more helpful relationships with their patients if they understand the etiologies of these diverse expressions of sexual humanity. Multidisciplinary evidence reveals that a sexually dimorphic spectrum of somatic and neurologic anatomy, traits and abilities, including sexual orientation and gender identity, are conferred together during the first half of pregnancy due to genetics, epigenetics and the diversity of timing and function of sex chromosomes, sex-determining protein secretion, gonadal hormone secretion, receptor levels, adrenal function, maternally ingested dietary hormones, fetal health, and many other factors...
April 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29604566/cirrhotic-patients-admitted-to-the-icu-for-medical-reasons-analysis-of-5506-patients-admitted-to-286-icus-in-8years
#14
Stefano Skurzak, Greta Carrara, Carlotta Rossi, Giovanni Nattino, Daniele Crespi, Michele Giardino, Guido Bertolini
PURPOSE: To describe characteristics and prognostic factors of cirrhotic patients admitted to a representative sample of Italian intensive care units (ICUs). MATERIALS AND METHODS: All patients admitted to 286 ICUs for medical reasons between 2002 and 2010 (excluding 2007) were considered. A logistic regression model was developed on cirrhotics to predict hospital mortality. The prediction was applied to different subgroups defined by both the level of unit expertise with cirrhotics and the overall unit performance, and compared to the actual mortality...
March 16, 2018: Journal of Critical Care
https://www.readbyqxmd.com/read/29602433/improving-resident-s-skills-in-the-management-of-circulatory-shock-with-a-knowledge-based-e-learning-tool
#15
David Riaño, Francis Real, Jose Ramon Alonso
BACKGROUND: Correct clinical management of circulatory shock in emergency departments (ER) and intensive care units (ICU) is critical. In this context, the transmission of professional skills by means of the practical supervision of real cases at the point of care entails important issues that can be widely overcome with the use of computer knowledge-based e-learning tools. OBJECTIVE: Shock-Instructor is a web-based e-learning tool implementing the already tested training program model (TPM) that uses a knowledge base about the evidence found in the clinical practice guidelines about seven types of shock...
May 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29580965/designing-a-nurse-delivered-delirium-bundle-what-intensive-care-unit-staff-survivors-and-their-families-think
#16
Leona Bannon, Jennifer McGaughey, Mike Clarke, Daniel F McAuley, Bronagh Blackwood
BACKGROUND: Implementation of quality improvement interventions can be enhanced by exploring the perspectives of those who will deliver and receive them. We designed a non-pharmacological bundle for delirium management for a feasibility trial, and we sought to obtain the views of intensive care unit (ICU) staff, survivors, and families on the barriers and facilitators to its implementation. OBJECTIVE: The objective of this study is to determine the barriers and facilitators to a multicomponent bundle for delirium management in critically ill patients comprising (1) education and family participation, (2) sedation minimisation and pain, agitation, and delirium protocol, (3) early mobilisation, and (4) environmental interventions for sleep, orientation, communication, and cognitive stimulation...
March 23, 2018: Australian Critical Care: Official Journal of the Confederation of Australian Critical Care Nurses
https://www.readbyqxmd.com/read/29574806/intercountry-master-s-degree-in-nursing-policy-implications-for-the-mozambican-health-system
#17
J C Bruce, S Schmollgruber, J Baumann
PURPOSE: Within an overarching evaluation framework, this study explored the experiences of course participants and administrators of an intercountry master's degree in nursing between South Africa and Mozambique. The lessons learnt were used to inform nursing and health policy for the Mozambican health system. METHODS: Kirkpatrick's four levels of training evaluation and a results-oriented approach to capacity change were integrated to form a hybrid evaluation framework to capture information about course implementation and the context/environment within which it was delivered...
March 24, 2018: International Nursing Review
https://www.readbyqxmd.com/read/29573099/nursing-history-as-philosophy-towards-a-critical-history-of-nursing
#18
Thomas Foth, Jette Lange, Kylie Smith
Mainstream nursing history often positions itself in opposition to philosophy and many nursing historians are reticent of theorizing. In the quest to illuminate the lives of nurses and women current historical approaches are driven by reformist aspirations but are based on the conception that nursing or caring is basically good and the timelessness of universal values. This has the effect of essentialising political categories of identity such as class, race and gender. This kind of history is about affirmation rather than friction and about the conservation of memory and musealization...
March 24, 2018: Nursing Philosophy: An International Journal for Healthcare Professionals
https://www.readbyqxmd.com/read/29571106/transition-support-for-new-graduate-and-novice-nurses-in-critical-care-settings-an-integrative-review-of-the-literature
#19
REVIEW
Tiana Innes, Pauline Calleja
Transition into critical care areas for new graduate nurses may be more difficult than transitioning into other areas due to the specialised knowledge needed. It is unknown which aspects of transition programs best support new graduate nurses improve competence and confidence to transition into critical care nursing specialties. Identifying these aspects would assist to design and implement best practice transition programs for new graduates in critical care areas. Themes identified in the literature include; having a designated resource person, workplace culture, socialisation, knowledge and skill acquisition, orientation, and rotation...
March 5, 2018: Nurse Education in Practice
https://www.readbyqxmd.com/read/29546468/patient-provider-communication-barriers-and-facilitators-to-hiv-and-sti-preventive-services-for-adolescent-msm
#20
Celia B Fisher, Adam L Fried, Kathryn Macapagal, Brian Mustanski
Adolescent males who have sex with males (AMSM) are at increased risk of contracting HIV/AIDS and other sexually transmitted infections (STIs). Healthcare providers are a critical source of HIV/STI prevention, yet little is known about AMSM patient-provider sexual health communications and services. To explore this issue, we surveyed a national sample of 198 AMSM 14-17 years. Four online psychometrically validated scales indicated over half the youth avoided communicating their sexual orientation and sexual health concerns to providers due to fear of heterosexist bias, concern their sexual health information would be disclosed to parents, and a general belief that sexual minority youth do not receive equitable treatment in health care settings...
March 15, 2018: AIDS and Behavior
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