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Mean corpuscular volume

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https://www.readbyqxmd.com/read/29142420/exploring-the-cytotoxic-potential-of-triterpenoids-enriched-fraction-of-bacopa-monnieri-by-implementing-in-vitro-in-vivo-and-in-silico-approaches
#1
Md Nasar Mallick, Washim Khan, Rabea Parveen, Sayeed Ahmad, Sadaf, Mohammad Zeeshan Najm, Istaq Ahmad, Syed Akhtar Husain
Background: Bacopa monnieri (BM) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. We hypothesized that the extract of the whole plant might contain numerous molecules with having antitumor activities that could be very effective in killing of human cancer cells. Objectives: This work investigated anticancer activity of bioactive fraction of BM. Materials and Methods: The hydroalcoholic extract of BM was fractionated with different solvent, namely, hexane, dichloromethane (DCM), acetone, methanol, and water...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140587/comparison-of-haematology-and-biochemistry-parameters-in-healthy-south-african-infants-with-laboratory-reference-intervals
#2
B Schmidt, M Tameris, H Geldenhuys, A Luabeya, E Bunyasi, T Hawkridge, J B McClain, H Mahomed, T J Scriba, H McShane, M Hatherill
OBJECTIVE: Paediatric laboratory reference intervals used in Africa and Asia may be derived from historical intervals of predominantly Caucasian infants in Europe or North America. These intervals may therefore not be compatible with the range of normality for developing country populations. We aimed to compare haematology and biochemistry parameters in healthy South African infants with local laboratory reference intervals. METHODS: We compared the baseline haematology and biochemistry results of 634 (316 male and 318 female) HIV-unexposed infants, aged 3-6 months, living in a rural area of the Western Cape Province, South Africa, against laboratory reference intervals supplied by the South African National Health Laboratory Services (NHLS)...
November 15, 2017: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29134976/uptake-of-zinc-by-pteridium-aquilinum-bracken-fern-and-response-of-clarias-gariepinus-juveniles-during-chronic-and-sub-lethal-exposure
#3
F E Olaifa, A A Fabusoro
Zinc is an essential trace element but can be toxic to fish at elevated concentrations. This study was carried out to assess the uptake of zinc by Clarias gariepinus juveniles and Pteridium aquilinum during chronic exposure to sub lethal concentrations. Two experiments were undertaken simultaneously in static renewal bioassays for 28 days.Haematology, histology, zinc accumulation in tissues of C.gariepinus and P. aquilinum were recorded fortnightly. Packed Cell Volume, haemoglobin concentration, Red Blood Cells, White blood cells, Lymphocytes, Neutrophils, Mean Corpuscular Volume, Mean Corpuscular Haemoglobin Concentration and Mean Corpuscular Haemoglobin of C...
June 30, 2017: Nigerian Journal of Physiological Sciences: Official Publication of the Physiological Society of Nigeria
https://www.readbyqxmd.com/read/29133146/association-of-genetic-polymorphisms-with-erythrocyte-traits-verification-of-snps-reported-in-a-previous-gwas-in-a-japanese-population
#4
Toshio Seiki, Mariko Naito, Asahi Hishida, Sahoko Takagi, Takashi Matsunaga, Tae Sasakabe, Yuta Hattori, Sayo Kawai, Rieko Okada, Guang Yin, Nobuyuki Hamajima, Kenji Wakai
Erythrocyte count and volume are the commonly used hematological indices for anemia that change in various diseases. To date, however, only one study ever exists that addressed erythrocyte trait-associated single nucleotide polymorphisms (SNPs) in a Japanese population. Because that study was performed in patients with various diseases, we confirmed the reported associations in a general population. Participants in the current study were from the Shizuoka component of the Japan Multi-Institutional Collaborative Cohort Study, which included 4971 men and women aged 35 to 69years who were recruited between 2006 and 2007...
November 10, 2017: Gene
https://www.readbyqxmd.com/read/29128046/preoperative-anemia-in-cardiac-operation-does-hemoglobin-tell-the-whole-story
#5
Lu Dai, Stephanie L Mick, Keith R McCrae, Penny L Houghtaling, Joseph F Sabik, Eugene H Blackstone, Colleen G Koch
BACKGROUND: Preoperative anemia, defined by hemoglobin level, is associated with elevated risk after cardiac operation. Better understanding of anemia requires characterization beyond this. This investigation focuses on red cell size and its association with patient characteristics and outcomes after cardiac operation. METHODS: From January 2010 to January 2014, 10,589 patients underwent elective cardiac operations at Cleveland Clinic. Anemia was characterized as normocytic, microcytic, or macrocytic based on mean corpuscular volume (MCV)...
November 8, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29125799/body-growth-and-rapid-hematological-development-support-breath-hold-of-baby-belugas-delphinapterus-leucas-during-subice-transit
#6
Shawn R Noren, Caryn P Poll, Matthew S Edwards
Body size and oxygen stores in the blood and muscle set breath-hold limits in marine mammals, yet these characteristics are understudied in immature cetaceans. We examined body mass and hematology from birth through adulthood in beluga whales (Delphinapterus leucas). At birth, body mass was 8% and 6% of the maximum mass recorded for adult females and males, respectively. Body mass then increased rapidly, approaching an asymptote around 12 yr for females and 18 yr for males. Interestingly, red blood cell counts, hemoglobin content, and hematocrit levels decreased after birth; this neonatal anemia was reversed as levels increased after 2 mo postpartum...
January 2018: Physiological and Biochemical Zoology: PBZ
https://www.readbyqxmd.com/read/29124980/prenatal-diagnosis-and-molecular-analysis-of-a-large-novel-deletion-js-causing-%C3%AE-0-thalassemia
#7
Jinru Cao, Shuzhen He, Yudong Pu, Jingjing Liu, Fuping Liu, Jun Feng
α-Thalassemia (α-thal) is a very common single gene hereditary disease caused by large deletions or point mutations of the α-globin gene cluster in tropical and subtropical regions of the world. Here, we report for the first time, a novel large α-thal deletion in a Chinese family from Jiangsu Province, People's Republic of China (PRC), which removes almost the entire α2 and α1 genes from the α-globin gene cluster. Thus, it was named the Jiangsu deletion (- -(JS)) on the α-globin gene cluster causing α(0)-thal...
November 10, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29122793/developing-a-classification-system-for-haemoglobin-management-in-patients-with-end-stage-renal-disease-on-haemodialysis-a-secondary-data-analysis
#8
Tibor Kesztyüs, Ulrich Simonsmeier, Dorothea Kesztyüs
BACKGROUND: Ongoing discussion on anaemia management and target haemoglobin (Hb) levels in patients on haemodialysis with erythropoietin treatment require a systematic approach in evaluating current practice. Aim of the present study was to develop a new classification system to easily monitor Hb trajectories and categorise patients on haemodialysis. METHODS: Routine data from five dialysis centres in the USA collected between 2010 and 2016. Data were anonymised and only those from patients with fortnightly Hb values were included in the analysis...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29112667/pica-in-pregnancy-an-unusual-presentation
#9
Katharine E Epler, Arand Pierce, Valerie J Rappaport
BACKGROUND: Pica is common in pregnancy and is often felt to be benign. The following case of severe pica presenting without anemia is unusual in its presentation, laboratory findings, and treatment. CASE: A 31-year-old multiparous woman at 37 0/7 weeks of gestation presented with esophagitis and gastritis secondary to laundry detergent consumption. She had borderline anemia (hemoglobin of 11 g/dL and hematocrit of 37%, mean corpuscular volume 80%) but was severely iron-deficient (serum ferritin 7 micrograms/dL)...
November 3, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29082343/change-of-various-characteristics-between-spawning-and-non-spawning-season-in-diploid-and-induced-triploid-far-eastern-catfish-silurus-asotus
#10
Sun Young Lim, Hyun Woo Gil, In-Seok Park
The purpose of this study is to investigate the differences fatty acids and hormonal parameters in the spawning and non-spawning season between the diploid and induced triploid Far Eastern catfish, Silurus asotus. The measured triploids were produced by cold shock for 50 min at 4℃ in May 2014, the spawning season of diploid was in May, and the non-spawning season was designated in January. Estradiol and testosterone and gonadosomatic index of diploid were higher than those of induced triploid in spawning season (P<0...
September 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29082340/starvation-induced-physiological-responses-and-rna-dna-ratios-in-rock-bream-oplegnathus-fasciatus-and-olive-flounder-paralichthys-olivaceus
#11
In-Seok Park, Hyun Woo Gil, Bong-Seok Kim, Kwan-Ha Park, Sung-Yong Oh
In a 12-week experiment, the rock bream, Oplegnathus fasciatus, and olive flounder, Paralichthys olivaceus, were investigated to determine the effects of starvation on their physiological parameters. The protein and DNA contents of the starved fish were significantly higher than the initial values and those of the fed fish. The RNA contents and RNA/DNA ratios of the fed fish were significantly higher than those of the other groups (P<0.05). The hematocrit, hemoglobin, red blood cells (RBC), and mean corpuscular volume (MCV) of the fed rock bream were significantly higher than at baseline (P<0...
September 2017: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/29072032/training-induced-annual-changes-in-red-blood-cell-profile-in-highly-trained-endurance-and-speed-power-athletes
#12
Monika Ciekot-Sołtysiak, Krzysztof Kusy, Tomasz Podgórski, Jacek Zieliński
BACKGROUND: An extensive body of literature exists on the effects of training on haematological parameters, but the previous studies have not reported how hematological parameters respond to changes in training loads within consecutive phases of the training cycle in highly-trained athletes in extremely different sport disciplines. The aim of this study was to identify changes in red blood cell (RBC) profile in response to training loads in consecutive phases of the annual training cycle in highly-trained sprinters (8 men, aged 24 ± 3 years) and triathletes (6 men, aged 24 ± 4 years) who competed at the national and international level...
October 24, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29068786/effect-of-sub-chronic-ferrous-sulfate-treatment-on-motor-skills-haematological-and-biochemical-parameters-in-rats
#13
Mohamed Ammari, Miryam Elferchichi, Haifa Othman, Mohsen Sakly, Hafedh Abdelmelek
This study investigated the effects of ferrous sulfate (FeSO4) on motor skills, haematological and biochemical parameters in rats. Adult rats were treated with dose of iron (280mg/l, per os) for 15 consecutive days in drinking water. No significant difference was noticed for the motor skill in the stationary beam (p = 0.23) and suspended string tests (p = 0.48) between control and iron treated rats. However, Iron treated rats showed a significant increase in White Blood Cells count (p = 0.01), Mean corpuscular volume values (p = 0...
October 25, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/29067069/can-hematologic-parameters-predict-treatment-of-ectopic-pregnancy
#14
Hatice Akkaya, Gulsum Uysal
OBJECTIVE: Ectopic pregnancy (EP) is the major cause of maternal morbidity and mortalityinthe first trimester of pregnancy. EP can be treated either medical or surgical approches. The purpose of our study wasto predict the treatment choice of tubal EP by usinghematologic parameters which are routinely used in clinical practice. METHODS: After retrospectively data evaluation was done from Januaryu 2014 to Deceber 201. we had 153 patients with EP. Patientsadmitted to methotrexate (MTX) therapy was Group-1...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29063903/iron-and-vitamin-d-levels-among-autism-spectrum-disorders-children
#15
Abdulbari Bener, Azhar O Khattab, Dinesh Bhugra, Georg F Hoffmann
AIM: The aim of this study was to investigate iron deficiency anemia and Vitamin D deficiency among autism children and to assess the importance of risk factors (determinants). SUBJECTS AND METHODS: This was a case-control study conducted among children suffering from autism at the Hamad Medical Corporation in Qatar. A total of 308 cases and equal number of controls were enrolled. The Autism Diagnostic Observation Schedule-Generic was the instrument used for diagnosis of Autism...
October 2017: Annals of African Medicine
https://www.readbyqxmd.com/read/29063708/haematological-indices-and-haematinic-levels-after-mini-gastric-bypass-a-matched-comparison-with-roux-en-y-gastric-bypass
#16
B M Madhok, K K Mahawar, J N Hadfield, M Courtney, A Stubbing-Moore, S Koshy, P K Small
Many surgeons believe mini gastric bypass (MGB) is more likely to cause micronutrient malabsorption compared to Roux-en-Y gastric bypass (RYGB). Till date, there is no published study evaluating haematological indices and haematinic levels in patients undergoing MGB and comparing these with a matched cohort of RYGB. Two hundred patients who underwent MGB between October 2012 and October 2015 were matched to 200 patients who underwent RYGB for age, sex, body mass index and time of surgery. We then compared haemoglobin, mean corpuscular volume, iron, ferritin, vitamin B12 and folic acid levels preoperatively and at 6 monthly intervals after surgery until 2 years...
October 23, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29061498/effect-of-a-red-blood-cell-transfusion-on-biological-markers-used-to-determine-the-cause-of-anemia-a-prospective-study
#17
Antoine Froissart, Benjamin Rossi, Brigitte Ranque, Irène Jarrin, Jean-François Bergmann, Sébastien Beaune, Sandrine Dautheville, Nicole Breau, Agnès Dauvergne, Lauréline Deluche, Tiphaine Robert, Nathalie Gault, Carine Roy, Virginie Zarrouk, Olivier Steichen, Bruno Fantin
BACKGROUND: Blood test results required for the evaluation of anemia are considered difficult to interpret after red blood cell transfusion. However, this hypothesis is neither supported by a strong physiological rationale nor is it evidence based. METHODS: We conducted a prospective multicenter study to compare the values of key assays before and after a course of red blood cell transfusion in the emergency or internal medicine units in four university hospitals...
October 20, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29042854/influence-of-standard-laboratory-procedures-on-measures-of-erythrocyte-damage
#18
Lena Wiegmann, Diane A de Zélicourt, Oliver Speer, Alissa Muller, Jeroen S Goede, Burkhardt Seifert, Vartan Kurtcuoglu
The ability to characterize the mechanical properties of erythrocytes is important in clinical and research contexts: to diagnose and monitor hematologic disorders, as well as to optimize the design of cardiovascular implants and blood circulating devices with respect to blood damage. However, investigation of red blood cell (RBC) properties generally involves preparatory and processing steps. Even though these impose mechanical stresses on cells, little is known about their impact on the final measurement results...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29038615/red-blood-cell-distribution-width-a-novel-predictive-indicator-for-cardiovascular-and-cerebrovascular-diseases
#19
REVIEW
Ning Li, Heng Zhou, Qizhu Tang
The red blood cell distribution width (RDW) obtained from a standard complete blood count (CBC) is a convenient and inexpensive biochemical parameter representing the variability in size of circulating erythrocytes. Over the past few decades, RDW with mean corpuscular volume (MCV) has been used to identify quite a few hematological system diseases including iron-deficiency anemia and bone marrow dysfunction. In recent years, many clinical studies have proved that the alterations of RDW levels may be associated with the incidence and prognosis in many cardiovascular and cerebrovascular diseases (CVDs)...
2017: Disease Markers
https://www.readbyqxmd.com/read/29038560/safety-assessment-of-antibiotic-and-probiotic-feed-additives-for-gallus-gallus-domesticus
#20
D P Neveling, L van Emmenes, J J Ahire, E Pieterse, C Smith, L M T Dicks
Antibiotics in feed select for resistant strains and is thus a threat to human health. In this study, the effect of a multi-strain probiotic and antibiotics on the growth and health of broilers was studied. Equal numbers of broilers received on a daily basis either a multi-strain probiotic or a combination of sulphadiazine, colistin and trimethoprim, whereas the control group received standard feed. The villi of immature broilers (19 days old) administered antibiotics had a larger surface area and their lymphocyte and basophil counts were higher compared to broilers from the probiotic and control groups...
October 16, 2017: Scientific Reports
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