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Mean corpuscular volume

Joré Céline, Brun Jean-Frédéric, Varlet-Marie Emmanuelle
Erythropoietin (EPO) is a major regulator of blood viscosity. Its long lasting action analogue methoxy polyethylene glycol-epoetin-β (MIRCERA®) seems to be also employed in modern doping. We took the opportunity of a study aiming at developing a detection of recent MIRCERATM injection in the context of doping detection to assess the effects of this EPO analogue on red blood cells (RBC) aggregation. A single dose 200 μg of MIRCERA® was injected to 10 male volunteers and blood samplings were drawn over 24 days...
October 17, 2016: Clinical Hemorheology and Microcirculation
Christopher Didigwu Nwani, Peace Onas Somdare, Juliana Adimonye Ukonze, Vincent Chikwendu Ejere, Alfreda O Nwadinigwe, Jacinta Chinedu Nwani, Gregory Ejike Odo, Ogechi Nnabuchi Ugbor
In this study, African Catfish (also known as Sharptooth Catfish) Clarias gariepinus were exposed to sublethal concentrations of fenthion of 2.0, 4.0, and 8.0 mg/L for 21 d and allowed to recover for 7 d to investigate the potential for hematological changes. Whole blood was sampled on days 1, 7, 14, and 21 postexposure and after a 7-d recovery period. During exposure, fenthion caused a reduction in red blood cell counts, hemoglobin concentration, and packed cell volume. There was an increase in white blood cell counts but no significant difference in mean corpuscular hemoglobin concentration, mean corpuscular volume, and mean corpuscular hemoglobin...
December 2016: Journal of Aquatic Animal Health
O Naseer, J A Khan, M S Khan, M O Omer, G A Chishti, M L Sohail, M U Saleem
Aflatoxins are secondary metabolites produced by Aspergillus spp. which are injurious to animals and humans The aim of this study was to determine the effects of aflatoxin B1 (AFB1) on Average Daily Feed Intake (ADFI), Average Daily Weight Gain (ADWG), haematological and serum biochemical responses of Bovine Calves and to determine the comparative efficacy of two different liver tonics against AFB1. Twenty seven calves were selected from herd and divided into 3 groups. All calves were fed with 1.0 mg/kg AFB1 for a period of 10 days...
September 1, 2016: Polish Journal of Veterinary Sciences
Moninder Narang, Mukul Singh, Shruti Dange
OBJECTIVE: To study alterations in and factors affecting blood levels of homocysteine and its related vitamins (B12 and folic acid) in patients with metabolic syndrome. Methods: In this case-control study, conducted in a referral hospital in north India, blood levels of vitamin B12, folic acid and homocysteine were compared and also correlated with anthropometric parameters, blood sugar, lipids (total, LDL and HDL cholesterol) and hematological variables. METHODS: Seventy five subjects (50 patients and 25 controls; mean age 48...
July 2016: Journal of the Association of Physicians of India
Maria T Bourlon, Dexiang Gao, Sara Trigero, Julia E Clemons, Kathryn Breaker, Elaine T Lam, Thomas W Flaig
Increases in the mean corpuscular volume (MCV) have been observed in patients with metastatic renal cell carcinoma (mRCC) on tyrosine kinase inhibitor (TKI) treatment; however, its association with progression-free-survival (PFS) is unknown. We aimed to characterize TKI-associated macrocytosis in mRCC and its relationship with PFS. Retrospective review of data on macrocytosis and thyroid dysfunction on mRCC patients treated with sunitinib and/or sorafenib. These results are evaluated in the context of our previous report on the association of hypothyroidism in this setting...
October 19, 2016: Cancer Medicine
Farzaneh Karimi-Alavijeh, Saeed Jalili, Masoumeh Sadeghi
BACKGROUND: Metabolic syndrome which underlies the increased prevalence of cardiovascular disease and Type 2 diabetes is considered as a group of metabolic abnormalities including central obesity, hypertriglyceridemia, glucose intolerance, hypertension, and dyslipidemia. Recently, artificial intelligence based health-care systems are highly regarded because of its success in diagnosis, prediction, and choice of treatment. This study employs machine learning technics for predict the metabolic syndrome...
May 2016: ARYA Atherosclerosis
Yu-Liang Zhan, Bin Zou, Ting Kang, Ling-Bing Xiong, Jin Zou, Yun-Feng Wei
BACKGROUND: Accumulating evidence suggests that increased red cell distribution width (RDW) and mean corpuscular volume (MCV) were both poor prognostic factors for patients with cardiovascular diseases. Recently, the multiplicative interaction between RDW and MCV has been observed for predicting mortality in elderly patients without anemia; however, the relationship between the product of RDW-MCV and hypertension-induced target organ damage (TOD) has not been evaluated. METHODS: We performed a cross-sectional study in 1115 hypertensive patients...
October 13, 2016: Journal of Clinical Laboratory Analysis
T Vuk, J Bingulac-Popović, T Očić, L J Mayer, M Milošević, I Jukić
OBJECTIVES: The aim of this study was to assess the appropriateness of using combined cell index (CCI) in the assessment of iron stores in blood donors. This index is calculated by the formula: red blood cell distribution width (RDW) × 10(4) × mean corpuscular volume (MCV)(-1) × mean corpuscular haemoglobin (MCH)(-1) . BACKGROUND: Ferritin measurement is a reliable method for estimating iron stores in blood donors. The sensitivity of red blood cell (RBC) parameters of complete blood count in detecting non-anaemic iron deficiency is significantly lower...
October 11, 2016: Transfusion Medicine
Zahide Yalaki, Selda Ozmen, Medine Aysin Tasar, Yildiz Dallar
Breast feeding is the first and most important step of a healthy diet. Breast milk contains important vitamins and trace elements such as iron, zinc, copper, and vitamin A. The aim of our study was to evaluate the levels of hemoglobin, hematocrit, mean corpuscular volume, serum iron, iron binding capacity, ferritin, serum zinc, copper and vitamin A in three groups of infants, which were determined based on feeding practices. The infants in all groups were not given prophylactic iron in the first 6 mo. Two hundred fifty-nine infants were included in the study...
2016: Journal of Nutritional Science and Vitaminology
Brenda Hartman, Mary Donnelly-VanderLoo, Tiffany Watson, Colleen O'Connor, Janet Madill
The risk for impaired vitamin B12 status increases with age, as does the use of proton pump inhibitors (PPI). Long-term use of PPIs is associated with several nutritional deficiencies including B12. Currently, there are no recommendations for B12 screening among patients taking PPIs. Data were abstracted on B12 concentrations, B12-containing supplement use, medications, and select hematological values from a retrospective chart review of 658 adults, 391 with serum B12 concentrations, admitted to 6 different medical units at 2 regional hospitals in Southwestern Ontario between 2010 and 2012...
June 23, 2016: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
Sima M Derakhshan, Mahmoud S Khaniani, Fateme Afkhami, Abbasali H PourFeizi
The aim of this study was to determine the molecular spectrum and frequency of deletional and nondeletional α-thalassemia (α-thal) mutations and the genotype-phenotype correlation in common mutations in the Azeri population of Northwestern Iran. A total of 1256 potential carriers with microcytic and hypochromic anemia and normal Hb A2 levels (<3.5%) and without iron deficiency anemia plus three fetuses, were identified. Multiplex gap-polymerase chain reaction (gap-PCR) and sequencing for α-thal mutations were carried out...
September 30, 2016: Hemoglobin
Ildefonso Pulido, Miguel Genebat, Ana I Alvarez-Rios, Rebeca S De Pablo-Bernal, Mohammed Rafii-El-Idrissi Benhnia, Yolanda M Pacheco, Ezequiel Ruiz-Mateos, Manuel Leal
Toxicities related to the use of nucleoside analogues have increased the interest in developing nucleoside-sparing regimens, mainly combining protease inhibitors with raltegravir. However, data regarding the use of CCR5-antagonists in this setting and in the naive scenario are scarce. The main objective was to analyze the immunovirological efficacy and tolerability of a low-dose, once-daily, maraviroc (MVC)-containing, nucleoside reverse transcriptase inhibitor-sparing dual therapy compared with standard triple therapy after 48 weeks for naive HIV-infected patients in the routine clinical practice setting...
October 2016: Viral Immunology
Santiago Rodriguez-Segade, Javier Rodriguez Garcia, José M García-López, Francisco Gude, Felipe F Casanueva, Santiago Rs-Alonso, Félix Camiña
BACKGROUND: Several hematological alterations are associated with altered hemoglobin A1c (Hb A1c). However, there have been no reports of their influence on the rates of exceeding standard Hb A1c thresholds by patients for whom Hb A1c determination is requested in clinical practice. METHODS: The initial data set included the first profiles (complete blood counts, Hb A1c, fasting glucose, and renal and hepatic parameters) of all adult patients for whom such a profile was requested between 2008 and 2013 inclusive...
September 27, 2016: Clinical Chemistry
Julia K Rohr, Prudence Ive, C Robert Horsburgh, Rebecca Berhanu, Kate Shearer, Mhairi Maskew, Lawrence Long, Ian Sanne, Jean Bassett, Osman Ebrahim, Matthew P Fox
INTRODUCTION: A substantial number of patients with HIV in South Africa have failed first-line antiretroviral therapy (ART). Although individual predictors of first-line ART failure have been identified, few studies in resource-limited settings have been large enough for predictive modelling. Understanding the absolute risk of first-line failure is useful for patient monitoring and for effectively targeting limited resources for second-line ART. We developed a predictive model to identify patients at the greatest risk of virologic failure on first-line ART, and to estimate the proportion of patients needing second-line ART over five years on treatment...
2016: Journal of the International AIDS Society
Tomotaka Murashige, Daisuke Sakota, Ryo Kosaka, Masahiro Nishida, Yasuo Kawaguchi, Takashi Yamane, Osamu Maruyama
Plasma skimming is a phenomenon in which discharge hematocrit is lower than feed hematocrit in microvessels. Plasma skimming has been investigated at a bearing gap in a spiral groove bearing (SGB), as this has the potential to prevent hemolysis in the SGB of a blood pump. However, it is not clear whether plasma skimming occurs in a blood pump with the SGB, because the hematocrit has not been obtained. The purpose of this study is to verify plasma skimming in an SGB of a centrifugal blood pump by developing a hematocrit measurement method in an SGB...
September 2016: Artificial Organs
Cornelis L Harteveld, Serge Pissard, Anna M H Korver, Jean Riou, Eric Legac, Gideon Lansbergen, Inge L Pardijs, Piero C Giordano, Florens G A Versteegh
We report two families, members of which are carriers of a novel hemoglobin (Hb) variant that was named Hb Olivet [α13(A11)Ala→Thr (α1) (GCC > ACC); HBA1: c.40G > A; p.Ala14Thr]. The analysis of these cases allowed a clear description of this anomaly that behaves as a silent Hb. In the first family, of Portuguese ethnicity living in France, the proband, a 24-year-old male and his 57-year-old mother, both appeared to be carriers. The son presented with borderline mean corpuscular volume (MCV), while the mother was normocytic and normochromic...
September 14, 2016: Hemoglobin
Amber C Beckett, M Blanca Piazuelo, Jennifer M Noto, Richard M Peek, M Kay Washington, Holly M Scott Algood, Timothy L Cover
Epidemiologic studies have provided conflicting data regarding an association between H. pylori infection and iron deficiency anemia (IDA) in humans. Here, a Mongolian gerbil model was used to investigate a potential role of H. pylori infection, as well as a possible role of diet, in H. pylori-associated IDA. Mongolian gerbils (either H. pylori-infected or uninfected) received a normal diet or one of three diets associated with increased H. pylori virulence: high salt, low iron, or combination high salt/low iron...
September 12, 2016: Infection and Immunity
Voon Ong, Grayson Hough, Michael Schlosser, Ken Bartizal, James M Balkovec, Kenneth D James, B Radha Krishnan
Fungal infections pose a significant public health burden with high morbidity and mortality. CD101 is a novel echinocandin under development for the treatment and prevention of systemic Candida infections. Preclinical studies were conducted to evaluate the metabolic stability, plasma protein binding, pharmacokinetics, toxicity, and efficacy of CD101 at various dose levels. CD101 was stable to biotransformation in rat/monkey/human liver microsomes and rat/monkey/dog/human hepatocytes. In vitro studies suggest minimal interaction with recombinant cytochrome P450 enzymes (IC50 values >10 μM)...
September 12, 2016: Antimicrobial Agents and Chemotherapy
N Raza
Objectives: To gain baseline knowledge about frequency, severity and types of anaemia among prospective urban replacement blood donors. Methods: A prospective study was carried out at the blood bank of a tertiary care hospital in Karachi, Pakistan, on temporarily rejected male blood donors due to anaemia based on pre-donation complete blood counts. Severity of anaemia was determined according to World Health Organization (WHO) criteria into mild, moderate and severe...
February 17, 2016: West Indian Medical Journal
S Yasmeen, N Aktar, E Azim, S Siddique, S M Shah, M A Chaklader, S Khatun, R C Debnath, M M Rahman, M N Bari
Iron deficiency anaemia is a major public health problem in pregnancy. About 58% of pregnant women in developed countries are anaemic mainly due to iron deficiency resulting a serious negative consequences on children, mothers and eventually on the nation. This quasi-experimental multi centered study (Before after study) was done to evaluate the efficacy and tolerability of Iron Polymaltose Complex (IPC) in the treatment of iron deficiency anaemia and it was performed at the OPD of Bangladesh Medical College and two other clinics of Dhaka city from August 2011 to September 2013...
July 2016: Mymensingh Medical Journal: MMJ
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