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https://www.readbyqxmd.com/read/28097001/mag-dpa-curbs-inflammatory-biomarkers-and-pharmacological-reactivity-in-cytokine-triggered-hyperresponsive-airway-models
#1
Rayan Khaddaj-Mallat, Roddy Hiram, Chantal Sirois, Marco Sirois, Edmond Rizcallah, Sofia Marouan, Caroline Morin, Éric Rousseau
Bronchial inflammation contributes to a sustained elevation of airway hyperresponsiveness (AHR) in asthma. Conversely, omega-3 fatty acid derivatives have been shown to resolve inflammation in various tissues. Thus, the effects of docosapentaenoic acid monoacylglyceride (MAG-DPA) were assessed on inflammatory markers and reactivity of human distal bronchi as well as in a cultured model of guinea pig tracheal rings. Human bronchi were dissected and cultured for 48 h with 10 ng/mL TNF-α or IL-13. Guinea pig tracheas were maintained in organ culture for 72 h which was previously shown to trigger spontaneous AHR...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28096304/antibiotic-cycling-and-antibiotic-mixing-which-one-best-mitigates-antibiotic-resistance
#2
R E Beardmore, R Pena-Miller, F Gori, J Iredell
Can we exploit our burgeoning understanding of molecular evolution to slow the progress of drug resistance? One role of an infection clinician is exactly that: to foresee trajectories to resistance during antibiotic treatment and to hinder that evolutionary course. But can this be done at a hospital-wide scale? Clinicians and theoreticians tried to when they proposed two conicting behavioural strategies that are expected to curb resistance evolution in the clinic, these are known as 'antibiotic cycling' and 'antibiotic mixing'...
January 17, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28096027/work-related-musculoskeletal-disorders-in-primary-health-care-nurses
#3
Tânia Ribeiro, Florentino Serranheira, Helena Loureiro
BACKGROUND: Work related musculoskeletal disorders (WRMSDs) constitute a serious occupational health problem among registered nurses (RN) all around the world. Its prevalence is mainly associated with nurses' high physical demands that still remain poorly studied in primary health care (PHC). PURPOSE: To describe nurses' self-reported symptoms of WRMSDs (mainly discomfort and pain) in PHC, featuring the main work tasks that may have risk factors for its development...
February 2017: Applied Nursing Research: ANR
https://www.readbyqxmd.com/read/28091862/the-role-of-adolescent-friendship-group-integration-and-cohesion-in-weapon-related-violent-crime-as-a-young-adult
#4
Marlon P Mundt, Olena P Antonaccio, Michael T French, Larissa I Zakletskaia
Weapon-related violent crime is a serious, complex, and multifaceted public health problem. The present study uses data from Waves I and III of Add Health (n = 10,482, 54% female) to examine how friendship group integration and cohesion in adolescence (ages 12-19) is associated with weapon-related criminal activity as a young adult (ages 18-26). Results indicate that greater cohesion in friendship groups is associated with significantly lower weapon-related criminal activity in young adulthood. In addition, for adolescent girls, a greater number of close friendship ties-an indicator of friendship group integration-is associated with less weapon-related criminal activity in young adulthood...
January 16, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28089842/curbing-tumorigenesis-and-malignant-progression-through-the-pharmacological-control-of-the-wound-healing-process
#5
REVIEW
Melania Dovizio, Angela Sacco, Paola Patrignani
The prevention of cancer development and its progression is an urgent unmet medical need. Novel knowledge on the biology of cancer has evidenced that genetic changes occurring within cancer cells contribute, but are not sufficient, for tumor promotion and progression. The results of clinical studies and experimental animal models have suggested pursuing new avenues for the prevention of cancer development in the early stages, by using drugs that modulate platelet responses and those interfering with the synthesis and action of the mediators of inflammation...
January 12, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28088011/particulates-and-noise-exposure-during-bicycle-bus-and-car-commuting-a-study-in-three-european-cities
#6
Enembe O Okokon, Tarja Yli-Tuomi, Anu W Turunen, Pekka Taimisto, Arto Pennanen, Ilias Vouitsis, Zissis Samaras, Marita Voogt, Menno Keuken, Timo Lanki
BACKGROUND: In order to curb traffic-related air pollution and its impact on the physical environment, contemporary city commuters are encouraged to shift from private car use to active or public transport modes. However, personal exposures to particulate matter (PM), black carbon and noise during commuting may be substantial. Therefore, studies comparing exposures during recommended modes of transport versus car trips are needed. METHODS: We measured personal exposure to various-sized particulates, soot, and noise during commuting by bicycle, bus and car in three European cities: Helsinki in Finland, Rotterdam in the Netherlands and Thessaloniki in Greece using portable monitoring devices...
January 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28077112/prevalence-and-factors-associated-with-hypertension-in-burkina-faso-a-countrywide-cross-sectional-study
#7
Joseph Kouesyandé Soubeiga, Tieba Millogo, Brice W Bicaba, Boukare Doulougou, Séni Kouanda
BACKGROUND: High blood pressure (HBP) is an increasing public health issue for developing countries. HBP is an important contributing factor to many non-communicable diseases that were until very recently thought to be rare in developing countries. There is not enough evidence on its burden and risk factors in Africa. We report in this study on the prevalence and factors associated with HBP in the adult and active population of Burkina Faso from a nationally representative sample. METHODS: We conducted a secondary analysis of data from the World Health Organization (WHO) Stepwise approach to Surveillance(STEPS) survey on the prevalence of major risk factors for non-communicable diseases in Burkina Faso...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28077033/governing-health-equity-in-scandinavian-municipalities-the-inter-sectorial-challenge
#8
Christian Elling Scheele, Ingvild Little, Finn Diderichsen
AIMS: Local governments in the Scandinavian countries are increasingly committed to reduce health inequity through 'health equity in all policies' (HEiAP) governance. There exists, however, only very sporadic implementation evidence concerning municipal HEiAP governance, which is the focus of this study. METHODS: Data are based on qualitative thematic network analysis of 20 interviews conducted from 2014 to 2015 with Scandinavian political and administrative practitioners...
January 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28072812/is-kratom-the-new-legal-high-on-the-block-the-case-of-an-emerging-opioid-receptor-agonist-with-substance-abuse-potential
#9
George C Chang-Chien, Charles A Odonkor, Prin Amorapanth
Kratom is an unscheduled opioid receptor agonist that comes in the form of dietary supplements currently being abused by chronic pain patients on prescription opioids. Active alkaloids isolated from kratom such as mitragynine and 7-hydroxymitragynine are thought to act on mu- and delta-opioid receptors as well as alpha-2 adrenergic and 5-HT2A receptors. Animal studies suggest that kratom may be more potent than morphine. Consequently, kratom consumption produces analgesic and euphoric feelings among users. In particular, some chronic pain patients on opioids take kratom to counteract the effects of opioid withdrawal...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28065553/trace-element-contamination-in-the-nearshore-sediments-of-the-tamiraparani-estuary-southeast-coast-of-india
#10
N S Magesh, N Chandrasekar, S Krishnakumar, T Simon Peter
The present study focused on the elemental distribution of nearshore environment and to understand the interrelationship between different parameters such as trace elements, organic matter, calcium carbonate and sediment texture. For this purpose, 24 surface samples were collected from the nearshore environment using a stainless steel Van Veen grab sampler. The above said parameters indicate that nearshore sediment transport, contaminants from estuarine source and anthropogenic activities deteriorates the sediment quality in the nearshore area...
January 5, 2017: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/28064064/the-role-of-physicians-in-prescribing-irrational-fixed-dose-combination-medicines-in-india
#11
Ajay Bhaskarabhatla, Chirantan Chatterjee
Many irrational fixed-dose combination (FDC) medicines have been approved by the state and central regulatory authorities in India and their use is promoted extensively by pharmaceutical firms. In this study, we examine the previously-neglected role of physicians in India, as their prescriptions are essential for the continued proliferation of FDCs. Primarily using longitudinal data on prescriptions by 4600 physicians spanning 19 disciplinary categories for 48 months between 2008 and 2011 provided by IMS Medical Audit, we study 201 medicines in the cardiovascular and oral-antidiabetic markets...
December 18, 2016: Social Science & Medicine
https://www.readbyqxmd.com/read/28060567/correlation-of-head-impacts-to-change-in-balance-error-scoring-system-scores-in-division-i-men-s-lacrosse-players
#12
Theresa L Miyashita, Eleni Diakogeorgiou, Kaitlyn Marrie
BACKGROUND: Investigation into the effect of cumulative subconcussive head impacts has yielded various results in the literature, with many supporting a link to neurological deficits. Little research has been conducted on men's lacrosse and associated balance deficits from head impacts. HYPOTHESES: (1) Athletes will commit more errors on the postseason Balance Error Scoring System (BESS) test. (2) There will be a positive correlation to change in BESS scores and head impact exposure data...
January 1, 2017: Sports Health
https://www.readbyqxmd.com/read/28060329/drug-repurposing-hypothesis-generation-using-the-re-fine-drugs-system
#13
Kelly Regan, Soheil Moosavinasab, Philip Payne, Simon Lin
The promise of drug repurposing is that existing drugs may be used for new disease indications in order to curb the high costs and time for approval. The goal of computational methods for drug repurposing is to enable solutions for safer, cheaper and faster drug discovery. Towards this end, we developed a novel method that integrates genetic and clinical phenotype data from large-scale GWAS and PheWAS studies with detailed drug information on the concept of transitive Drug-Gene-Disease triads. We created "RE:fine Drugs," a freely available, interactive dashboard that automates gene, disease and drug-based searches to identify drug repurposing candidates...
December 11, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059568/21st-century-parent-child-sex-communication-in-the-united-states-a-process-review
#14
Dalmacio Flores, Julie Barroso
Parent-child sex communication results in the transmission of family expectations, societal values, and role modeling of sexual health risk-reduction strategies. Parent-child sex communication's potential to curb negative sexual health outcomes has sustained a multidisciplinary effort to better understand the process and its impact on the development of healthy sexual attitudes and behaviors among adolescents. This review advances what is known about the process of sex communication in the United States by reviewing studies published from 2003 to 2015...
January 6, 2017: Journal of Sex Research
https://www.readbyqxmd.com/read/28057143/-infection-status-of-hiv-in-men-who-have-sex-with-men-in-nanjing-2011-2015
#15
Y Y Xu, Z P Zhu, S S Wu, Z Q Pu, L Liu, L Guo, M Zhang
Objective: To understand the current status of HIV infection in men who have sex with men (MSM) in Nanjing, explore the associated factors with HIV infection, and provide information for the intervention in MSM. Methods: Data collected in the consecutive sentinel surveillances among MSM during 2011-2015 includes MSM's social-demographic information, sexual behavior histories, access to HIV prevention services and HIV testing in the past year. The infection trend was analyzed with χ(2) test and the factors associated with HIV infection were identified through multivariate logistic regression analysis...
November 10, 2016: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28056829/seroprevalence-and-determinants-of-toxoplasmosis-in-pregnant-women-attending-antenatal-clinic-at-the-university-teaching-hospital-lusaka-zambia
#16
Christiana Frimpong, Mpundu Makasa, Lungowe Sitali, Charles Michelo
BACKGROUND: Toxoplasmosis is a neglected zoonotic disease which is prevalent among pregnant women especially in Africa. This study aimed to determine the seroprevalence and determinants of the disease among pregnant women attending antenatal clinic at the University Teaching Hospital (UTH). METHOD: A cross-sectional study was employed where 411 pregnant women attending antenatal clinic at UTH were interviewed using closed ended questionnaires. Their blood was also tested for Toxoplasma gondii IgG and IgM antibodies using the OnSite Toxo IgG/IgM Combo Rapid test cassettes by CTK Biotech, Inc, USA...
January 5, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28052932/lay-understanding-of-the-causes-of-binge-drinking-in-the-united-kingdom-and-australia-a-network-diagram-approach
#17
David A Keatley, Eamonn Ferguson, Adam Lonsdale, Martin S Hagger
Binge drinking is associated with deleterious health, social and economic outcomes. This study explored the lay understanding of the causes of binge drinking in members of the general public in the United Kingdom and Australia. Participants in the United Kingdom (N = 133) and Australia (N = 102) completed a network diagram exercise requiring them to draw causal paths and provide path strength ratings between 12 candidate factors (24-h opening, age, alcohol advertizing, alcohol availability, boredom, drinking culture, income, low cost, parental influence, peer pressure, stress and supermarket discounts) and binge drinking...
January 3, 2017: Health Education Research
https://www.readbyqxmd.com/read/28051354/effect-of-almond-supplementation-on-glycemia-and-cardiovascular-risk-factors-in-asian-indians-in-north-india-with-type-2-diabetes-mellitus-a-24-week-study
#18
Seema Gulati, Anoop Misra, Ravindra M Pandey
BACKGROUND: Type 2 diabetes (T2D) statistics have reached menacing proportions in India. Appropriate dietary intervention, as part of healthy lifestyle, is imperative to curb further spread of this disease. OBJECTIVES: This pre-post intervention study was conducted in New Delhi, India, to investigate the effects of daily consumption of almonds for 24 weeks in T2D subjects, specifically on measures of glycemia and cardiovascular disease (CVD) risk factors. METHODS AND STUDY DESIGN: In this study, the 24-week intervention period was preceded by a control diet and exercise run-in period of 3 weeks...
January 4, 2017: Metabolic Syndrome and related Disorders
https://www.readbyqxmd.com/read/28051105/evaluation-of-hdpe-and-ldpe-degradation-by-fungus-implemented-by-statistical-optimization
#19
Nupur Ojha, Neha Pradhan, Surjit Singh, Anil Barla, Anamika Shrivastava, Pradip Khatua, Vivek Rai, Sutapa Bose
Plastic in any form is a nuisance to the well-being of the environment. The 'pestilence' caused by it is mainly due to its non-degradable nature. With the industrial boom and the population explosion, the usage of plastic products has increased. A steady increase has been observed in the use of plastic products, and this has accelerated the pollution. Several attempts have been made to curb the problem at large by resorting to both chemical and biological methods. Chemical methods have only resulted in furthering the pollution by releasing toxic gases into the atmosphere; whereas; biological methods have been found to be eco-friendly however they are not cost effective...
January 4, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28049935/work-sleep-and-cholesterol-levels-of-u-s-long-haul-truck-drivers
#20
Michael K Lemke, Yorghos Apostolopoulos, Adam Hege, Laurie Wideman, Sevil Sonmez
Long-haul truck drivers in the United States experience elevated cardiovascular health risks, possibly due to hypercholesterolemia. The current study has two objectives: 1) to generate a cholesterol profile for U.S. long-haul truck drivers; and 2) to determine the influence of work organization characteristics and sleep quality and duration on cholesterol levels of long-haul truck drivers.Survey and biometric data were collected from 262 long-haul truck drivers. Descriptive analyses were performed for demographic, work organization, sleep, and cholesterol measures...
December 30, 2016: Industrial Health
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