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Endometriomas

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https://www.readbyqxmd.com/read/29779474/the-gametotoxic-effects-of-the-endometrioma-content-insights-from-a-parthenogenetic-human-model
#1
Alessio Paffoni, Valentina Bolis, Stefania Ferrari, Laura Benaglia, Paolo Vercellini, Edgardo Somigliana
The present randomized controlled in vitro study was designed to evaluate the effects of the exposure of human cryopreserved oocytes to endometriotic fluid. Twenty-three women aged 36 (4) years donated a total of 147 vitrified supernumerary metaphase II oocytes. Warmed oocytes were randomly assigned to exposure to endometriotic fluid or unexposed control. Thereafter, oocytes were parthenogenetically activated and cultured for up to 5 days. The rate of activation on day 1 and the developmental rates on days 3 and 5 did not significantly differ between the 2 groups...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29769513/ovarian-endometrioid-adenocarcinoma-arising-in-endometriosis-a-case-report
#2
K Nahar, B Ferdous, N Akhter, P A Shamsunnahar, K Khatun, S A Begum, M A Aziz
Malignant transformation of ovarian endometriosis was first described in 1925 by Sampson; later on it has been described in extragonadal regions by few authors also. Ovarian endometrioid and clear cell carcinoma are highly associated with endometriosis. Here we present a case of malignant transformation of ovarian endometrioma into endometrioid adenocarcinoma and review the clinical and pathological features of these tumors. A 45-years old infertile woman diagnosed as a case of bilateral chocolate cyst with pelvic endometriosis underwent total hysterectomy with bilateral salpingo-oophorectomy...
April 2018: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29759886/oocyte-retrieval-difficulties-in-women-with-ovarian-endometriomas
#3
Laura Benaglia, Andrea Busnelli, Rossella Biancardi, Walter Vegetti, Marco Reschini, Paolo Vercellini, Edgardo Somigliana
RESEARCH QUESTION: What are the frequency, characteristics and consequences of technical diffiiculties encountered by physicians when carrying out oocyte retrieval in women with ovarian endometriomas? DESIGN: We prospectively recruited women undergoing IVF and compared technical difficulties between women with (n = 56) and without (n = 227) endometriomas. RESULTS: In exposed women, the cyst had to be transfixed in eight cases (14%, 95% CI 7 to 25%) and accidental contamination of the follicular fluid with the endometrioma content was recorded in nine women (16%, 95% CI 8 to 27%)...
April 13, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29755032/effects-of-mature-cystic-teratoma-on-reproductive-health-and-malignant-transformation-a-retrospective-analysis-of-80-cases
#4
Sefa Kurt, Hüseyin Aytuğ Avşar, Ömer Erbil Doğan, Hasan Bahadır Saatli, Uğur Saygılı
OBJECTIVE: Examining the cases of mature cystic teratoma (MCT) that are diagnosed and treated in our clinic regarding their association with fertility; and detecting the rate of malignant degeneration and the types of malignancies. MATERIAL AND METHODS: Patients, operated due to adnexal mass between April 2012 and August 2017 and diagnosed with MCT, were retrospectively examined. Mean age of the 80 cases, which met the criteria, was 30.60±10.5. 9 were suffering from infertility, according to hospital records...
May 14, 2018: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/29750706/immunohistochemical-analysis-of-somatostatin-receptors-in-endometriosis-tissue-samples-a-retrospective-study
#5
Maxime Fastrez, Camille Marchisello, Marc Rassy, Serge Rozenberg, Nicolas Sirtaine
Three types of endometriosis are described: superficial peritoneal endometriosis (SPE), ovarian endometrioma (OMA), and deep infiltrating endometriosis (DIE). The expression of somatostatin receptors (SSTR1, 2, and 5) in human endometrial tissue and its ectopic form has been previously studied and may be different in each type of endometriosis. The aim of this study was to assess the immunohistochemical expression of SSTR1, 2, and 5 in tissue samples of SPE, OMA, and DIE. We performed a retrospective analysis in the pathology department database...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29747214/intestinal-perforation-due-to-deep-infiltrating-endometriosis-during-pregnancy-case-report
#6
Márcia Mendonça Carneiro, Luciana Maria Pyramo Costa, Maria Das Graças Torres, Patrícia Salomé Gouvea, Ivete de Ávila
We report the case of a 33 year-old woman who complained of severe dysmenorrhea since menarche. From 2003 to 2009, she underwent 4 laparoscopies for the treatment of pain associated with endometriosis. After all four interventions, the pain recurred despite the use of gonadotropin-releasing hormone (GnRH) analogues and the insertion of a levonorgestrel intrauterine system (LNG-IUS). Finally, a colonoscopy performed in 2010 revealed rectosigmoid stenosis probably due to extrinsic compression. The patient was advised to get pregnant before treating the intestinal lesion...
April 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29724140/anti-m%C3%A3-llerian-hormone-levels-and-spontaneous-pregnancy-in-women-undergoing-surgery-for-benign-ovarian-cysts
#7
Luisa Casadei, Francesca Dominici, Doriana Scaldaferri, Veronica Vicomandi, Susanna Ciacci, Emilio Piccione
This prospective study had the objective to compare anti-Müllerian hormone (AMH) serum levels among women with endometriomas and those with other benign ovarian cysts and verify a possible correlation between the AMH post-operative decline and the achievement of pregnancy. The study included 57 women undergoing laparoscopic surgery. Serum levels of AMH were measured preoperatively and at 6 and 12 months postoperatively. AMH serum levels decreased in both endometriomas and other benign cysts, but significant recovery was reported only in endometriomas (p = ...
May 4, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29716620/postprandial-increase-in-serum-ca125-as-a-surrogate-biomarker-for-early-diagnosis-of-ovarian-cancer
#8
Zhuowei Gu, Yifeng He, Yue Zhang, Mo Chen, Keqi Song, Yuting Huang, Qing Li, Wen Di
BACKGROUND: CA125 is a prevalently used serum biomarker for detecting ovarian cancer over the last three decades. However, it has a significant deficiency in screening for early-stage cancer. With the purpose of exploring an effective approach to improve its performance in early diagnosis, we investigated the postprandial fluctuation pattern of cancer-derived CA125 and the underlying mechanism. METHODS: In two medical centers, 551 patients sonographically diagnosed with ovarian (adnexal) cysts (< 5 cm in diameter) were enrolled and divided into five disease groups (pelvic inflammatory cysts, retention cysts, endometrioma, benign/borderline cystadenoma and malignant cysts)...
May 1, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29709485/endometriosis-surgery-and-preservation-of-fertility-what-surgeons-should-know
#9
H Roman
Colorectal surgeons often participate in the multidisciplinary management of young females with endometriosis. Complications of endometriosis as well as its management often result in infertility since they can involve all pelvic organs including the procreative organs: uterus, ovaries and fallopian tubes. Complete excision of all endometriotic lesions should not be performed at the expense of irreversible destruction of the procreative organs; definitive infertility should not be the price to pay in order to obtain an improvement of the painful symptoms caused by endometriosis...
April 27, 2018: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/29679753/daidzein-rich-isoflavone-aglycones-inhibit-cell-growth-and-inflammation-in-endometriosis
#10
O Takaoka, T Mori, F Ito, H Okimura, H Kataoka, Y Tanaka, A Koshiba, I Kusuki, S Shigehiro, T Amami, J Kitawaki
Endometriosis is an estrogen-dependent disease, and isoflavones interact with estrogen receptors. The purposes of this study are to investigate the in vitro and in vivo effects of daidzein-rich isoflavone aglycones (DRIAs), dietary supplements, on cellular proliferation in endometriosis. Stromal cells isolated from ovarian endometrioma (OESCs) and normal endometrium (NESCs) were cultured with DRIAs, i.e., each of the DRIA components (daidzein, genistein, or glycitein), or isoflavone glycosides (IG; DRIA precursors)...
April 18, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29662607/endom%C3%A3-triome-ombilical-%C3%A3-propos-d%C3%A2-un-cas-et-revue-de-la-litt%C3%A3-rature-umbilical-endometrioma-a-case-report-and-literature-review
#11
Omar Sow, William Valentin, Diouf Cheikh, Barboza Denis, Faye Samba Thiapato, Diallo Ibrahima, Gueye Serigne Modou Kane
Endometriosis is defined as the implantation of endometrial tissue outside of the uterine cavity. It affects approximately 10% of women of childbearing age. Umbilical endometriosis is rare and its pathophysiology is poorly known. We report the case of a 42-year old nulliparous female patient with a 5-year history of myomectomy, presenting with cyclic pain associated with umbilical mass. The diagnosis of umbilical endometrioma was made and confirmed by the histological examination of the surgical specimen. Treatment was based on wide excision of the mass associated with pelvis exploration and umbilical plasty...
2018: Pan African Medical Journal
https://www.readbyqxmd.com/read/29660008/exosomal-mir-214-from-endometrial-stromal-cells-inhibits-endometriosis-fibrosis
#12
Di Wu, Pan Lu, Xue Mi, Jinwei Miao
STUDY QUESTION: Is it possible to improve fibrosis in endometriosis by microRNA-214 delivery in exosomes? SUMMARY ANSWER: Upregulation of miR-214 may inhibit fibrogenesis and its delivery by exosomes derived from ectopic endometrial stromal cells, offers an alternative therapeutic approach for endometriosis fibrosis. WHAT IS KNOWN ALREADY: Fibrosis is the primary pathological feature of endometriosis. MiR-214 plays an important role in fibrotic disease...
April 11, 2018: Molecular Human Reproduction
https://www.readbyqxmd.com/read/29658437/decreased-expression-of-hoxa10-may-activate-the-autophagic-process-in-ovarian-endometriosis
#13
Jingjie Zheng, Xishao Luo, Jiaping Bao, Xiaowang Huang, Yi Jin, Lin Chen, Feiyun Zheng
Autophagy is a survival process that maintains homeostasis in all eukaryotic cells. Recent studies show an abnormal autophagic activity in endometriosis, but the role of autophagy is controversial. Homeobox A10 (HOXA10) is a transcription factor necessary for embryonic and adult uterine development, and studies indicate that its expression decreases in endometriosis. Homeobox A10 may negatively regulate autophagy in endometriosis. To test this hypothesis, we measured the expression levels of autophagic biomarkers (beclin-1 and LC3-II) and HOXA10 proteins by Western blotting and messenger RNA (mRNA) by quantitative real-time polymerase chain reaction...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29644329/fertility-preservation-in-women-with-ovarian-endometriosis
#14
Jacques Donnez, Javier García-Solares, Marie-Madeleine Dolmans
Endometriosis is a frequently encountered benign gynecological disease that may be responsible for infertility. Treatment of endometriosis-associated infertility has been investigated using both medical and surgical therapeutic modalities. Therapy has essentially three main objectives: (i) to preserve and improve fertility, (ii) to reduce pain, and (iii) to delay recurrence. The aim of this paper is to focus on fertility preservation in women with severe endometriosis. In ovarian endometriosis-associated infertility, a medico-surgical approach remains the gold standard, but more and more papers are reporting a low ovarian reserve after laparoscopic cystectomy for endometriomas...
April 11, 2018: Minerva Ginecologica
https://www.readbyqxmd.com/read/29642800/the-usefulness-of-cd34-pcna-immunoreactivity-and-histopathological-findings-for-prediction-of-pain-persistence-after-the-removal-of-endometrioma
#15
Akin Usta, Gulay Turan, Eren Altun, Meryem Hocaoglu, Cagla Bahar Bulbul, Ertan Adali
Endometriosis is an estrogen-dependent inflammatory disease that causes infertility and chronic pelvic pain. Ovarian endometrioma is the most common form of endometriosis, and conservative surgery is the main preferred therapeutic approach for endometrioma-associated symptoms. The aim of this study was to investigate the persistence of cyclic and noncyclic pelvic pain (NCPP) after endometrioma excision and their relationship to clinical and histopathological findings. In this prospective observational study, 41 symptomatic patients were evaluated for the presence of pain symptoms 3 to 6 months after endometrioma excision...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29610611/acupuncture-treatment-of-subfertility-and-ovarian-endometrioma
#16
Jihe Zhu, Blagica Arsovska, Andrijana Sterjovska-Aleksovska, Kristina Kozovska
BACKGROUND: Ovarian endometriotic cysts, also known as 'chocolate' cysts or ovarian endometriomas, appear as endometrial tissue outside the uterine cavity which grows inside ovaries. Endometriotic cysts can cause chronic pelvic pain, dysmenorrhea, dyspareunia, impairment of ovarian function in regards to subfertility, etc. Traditional Chinese Medicine (TCM) is effectively treating subfertility associated with endometriosis for years, and the treatment gives positive results in achieving pregnancy...
March 15, 2018: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29587615/25-hydroxyvitamin-d-serum-levels-and-endometriosis-results-of-a-case-control-study
#17
Laura Buggio, Edgardo Somigliana, Mara Nicoletta Pizzi, Dhouha Dridi, Elena Roncella, Paolo Vercellini
The immunomodulatory, anti-inflammatory, and antiproliferative properties of vitamin D have laid the basis for a possible function of this prohormone in the pathogenesis of endometriosis. The aim of this case-control study was to investigate vitamin D status, by measuring 25-hydroxyvitamin D [25(OH)D] serum levels, in women with and without endometriosis. Only Italian women of Caucasian origin aged between 18 and 45 years were deemed eligible. Enrollment was limited to the period October to May. Cases and controls were matched for month of recruitment and secondarily for age and parity...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29584612/elevated-serum-ca-19-9-with-adnexal-mass-is-it-always-an-ovarian-malignancy
#18
Kah Teik Chew, Izyan Atiqah Zakaria, Muhammad Azrai Abu, Mohd Faizal Ahmad, Erica Yee Hing, Nur Azurah Abdul Ghani
Endometriotic cysts a common benign gynaecological disease in women of reproductive age. We report an unusual case of ruptured endometrioma associated with increased CA 19-9. A 27-year-old woman presented with an acute abdomenal adnexal mass and elevated CA 19-9. The initial diagnosis of ovarian malignancy turned out to be a ruptured endometrioma, confirmed during surgery and in the histopathological report.
March 27, 2018: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29551389/perimenopausal-management-of-ovarian-endometriosis-and-associated-cancer-risk-when-is-medical-or-surgical-treatment-indicated
#19
REVIEW
Paolo Vercellini, Paola Viganò, Laura Buggio, Sofia Makieva, Giovanna Scarfone, Fulvia Milena Cribiù, Fabio Parazzini, Edgardo Somigliana
In women with endometriosis, the lifetime risk of ovarian cancer is increased from 1.4% to about 1.9%. The risk of clear cell and endometrioid ovarian cancer is, respectively, tripled and doubled. Atypical endometriosis, observed in 1-3% of endometriomas excised in premenopausal women, is the intermediate precursor lesion linking typical endometriosis and clear cell/endometrioid tumors. Prolonged oral contraceptive use is associated with a major reduction in ovarian cancer risk among women with endometriosis...
February 15, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29551300/-first-line-management-without-ivf-of-infertility-related-to-endometriosis-result-of-medical-therapy-results-of-ovarian-superovulation-results-of-intrauterine-insemination-cngof-has-endometriosis-guidelines
#20
J Boujenah, P Santulli, E Mathieu-d'Argent, C Decanter, C Chauffour, P Poncelet
INTRODUCTION: Using the structured methodology of French guidelines (HAS-CNGOF), the aim of this chapter was to formulate good practice points (GPP), in relation to optimal non-ART management of endometriosis related to infertility, based on the best available evidence in the literature. MATERIALS AND METHODS: This guideline was produced by a group of experts in the field including a thorough systematic search of the literature (from January 1980 to March 2017)...
March 15, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
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