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https://www.readbyqxmd.com/read/28931865/use-of-medroxyprogesterone-acetate-in-women-with-ovarian-endometriosis-undergoing-controlled-ovarian-hyperstimulation-for-in-vitro-fertilization
#1
Haiyan Guo, Yun Wang, Qiuju Chen, Weiran Chai, Lihua Sun, Ai Ai, Yonglun Fu, Qifeng Lyu, Yanping Kuang
This study investigated the use of medroxyprogesterone acetate (MPA) or a short protocol for controlled ovarian hyperstimulation (COH) in patients with advanced endometriosis who have normal ovarian function, and to compare cycle characteristics and pregnancy outcomes after frozen-thawed embryo transfer (FET). This was a retrospective case-control study of 244 patients with advanced endometriosis undering COH. The patients were allocated to three groups: the surgery group with MPA COH (62 patients, 71 IVF/ICSI cycles, 78 FET cycles); the aspiration group with MPA COH (85 patients had ovarian "chocolate" cysts (>3 cm) aspirated, 90 IVF/ICSI cycles, 76 FET cycles); and the short protocol group (97 patients, 101 IVF/ICSI cycles, 51 FET cycles)...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28930606/association-between-ovarian-endometrioma-and-ovarian-reserve
#2
Michio Kitajima, Khaleque Newaz Khan, Ayumi Harada, Ken Taniguchi, Tsuneo Inoue, Masanori Kaneuchi, Kiyonori Miura, Hideaki Masuzaki
Endometrioma is one of the main pathologies of endometriosis, though its pathogenesis still remains enigmatic. Ovarian reserve is defined as the number and quality of the follicles left in the ovary at any given time. The cause of infertility in women with endometriosis is multifactorial. Diminished ovarian reserve is major concern in women with endometriosis-associated infertility. Cystectomy for endometriomas could negatively impact on post-operative ovarian reserve. Some women had surgery for endometriomas suffer from poor ovarian response, which directly affects treatment results...
January 1, 2018: Frontiers in Bioscience (Elite Edition)
https://www.readbyqxmd.com/read/28925754/plasma-urocortin-1-as-a-preoperative-marker-of-endometriosis-in-symptomatic-women
#3
Laura M Maia, Ana L Rocha, Helen L Del Puerto, Felice Petraglia, Fernando M Reis
Accurate noninvasive diagnostic tests for endometriosis are still missing. This study evaluated the predictive value of the neuropeptide urocortin 1 (Ucn1) to detect pelvic endometriosis in symptomatic women. We enrolled prospectively 97 consecutive women submitted to gynecologic laparoscopy for chronic or acute pelvic pain, infertility or adnexal mass. Preoperative blood samples were assayed for Ucn1 using enzyme immunoassay. Patients with endometriosis had higher plasma Ucn1 levels compared to patients with no lesions (median 59 vs...
September 19, 2017: Gynecological Endocrinology
https://www.readbyqxmd.com/read/28911925/ethinylestradiol-20%C3%A2-%C3%AE-g-drospirenone-3%C3%A2-mg-in-a-flexible-extended-regimen-for-the-management-of-endometriosis-associated-pelvic-pain-a-randomized-controlled-trial
#4
Tasuku Harada, Saori Kosaka, Joerg Elliesen, Masanobu Yasuda, Makoto Ito, Mikio Momoeda
OBJECTIVE: To investigate the efficacy and safety of ethinylestradiol 20 μg/drospirenone 3 mg in a flexible extended regimen (FlexibleMIB) compared with placebo to treat endometriosis-associated pelvic pain (EAPP). DESIGN: A phase 3, randomized, double-blind, placebo-controlled, parallel-group study, consisting of a 24-week double-blind treatment phase followed by a 28-week open-label extension phase with an unblinded reference arm. SETTING: Thirty-two centers...
September 11, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28901638/adc-derived-spatial-features-can-accurately-classify-adnexal-lesions
#5
Anahita Fathi Kazerooni, Mahnaz Nabil, Hamidreza Haghighat Khah, Mohammadreza Alviri, Maryam Heidari-Sooreshjaani, Masoumeh Gity, Mahrooz Malek, Hamidreza Saligheh Rad
BACKGROUND: The role of quantitative apparent diffusion coefficient (ADC) maps in differentiating adnexal masses is unresolved. PURPOSE/HYPOTHESIS: To propose an objective diagnostic method devised based on spatial features for predicting benignity/malignancy of adnexal masses in ADC maps. STUDY TYPE: Prospective. POPULATION: In all, 70 women with sonographically indeterminate and histopathologically confirmed adnexal masses (38 benign, 3 borderline, and 29 malignant) were considered for this study...
September 13, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28891281/does-endometriosis-influence-the-age-of-menopause
#6
Jessica Ottolina, Ludovica Bartiromo, Paola Viganò, Sofia Makieva, Matteo Schimberni, Massimo Candiani
Endometriosis is an inflammatory disease affecting 7-10% of women throughout their reproductive life. Few data are available regarding the age at menopause of women affected by this disease. Most of the available evidence, although scanty, would indicate that both ovarian surgery for endometriomas and endometriosis "per se" appear to influence age at menopause. Other factors might interfere with the age at menopause of women affected by endometriosis. The purpose of this review is to examine the age at menopause in women with a history of endometriosis and to identify factors that might affect the timing of menopause...
September 5, 2017: Minerva Ginecologica
https://www.readbyqxmd.com/read/28888701/direct-mass-spectrometry-differentiation-of-ectopic-and-eutopic-endometrium-in-patients-with-endometriosis
#7
Leila Adamyan, Natalia Starodubtseva, Anna Borisova, Assia Stepanian, Vitaliy Chagovets, Dinara Salimova, Zhihao Wang, Alexey Kononikhin, Igor Popov, Anna Bugrova, Konstantin Chingin, Andrey Kozachenko, Huanwen Chen, Vladimir Frankevich
STUDY OBJECTIVE: To introduce a method for rapid assessment of endometriotic tissues using direct mass spectrometry (MS)-based lipidomics. DESIGN: Prospective observational cohort study. DESIGN CLASSIFICATION: II 2. SETTING: Department of Operative Gynecology of the Research Centre for Obstetrics, Gynecology and Perinatology. PATIENTS: Fifty patients with ovarian cysts and peritoneal endometriosis who underwent laparoscopic surgery between 2014 and 2016...
September 6, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28881264/is-endometrioma-associated-damage-to-ovarian-reserve-progressive-insights-from-ivf-cycles
#8
Laura Benaglia, Marta Castiglioni, Alessio Paffoni, Veronica Sarais, Paolo Vercellini, Edgardo Somigliana
OBJECTIVE: The relation between endometriomas and damage to ovarian reserve remains controversial. In this study, we hypothesized that this damage may not be present at the time of endometrioma formation but may conversely gradually develop over time. STUDY DESIGN: To investigate the possibility of a time-related detrimental effect of endometriomas on ovarian reserve, we retrospectively selected 29 women with unilateral cysts who underwent at least two IVF cycles at least 6 months apart and evaluated ovarian responsiveness over time...
September 1, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28869876/associations-between-internal-exposure-levels-of-persistent-organic-pollutants-in-adipose-tissue-and-deep-infiltrating-endometriosis-with-or-without-concurrent-ovarian-endometrioma
#9
Stéphane Ploteau, German Cano-Sancho, Christelle Volteau, Arnaud Legrand, Anaïs Vénisseau, Vincent Vacher, Philippe Marchand, Bruno Le Bizec, Jean-Philippe Antignac
Endometriosis is a gynaecological disease characterized by the presence of ectopic endometrial tissue. Histologically, it appears as different sub-types, being peritoneal endometriosis, ovarian endometrioma (OvE) and deep infiltrating endometriosis (DIE), which are of major relevance due to their varying clinical presentations. A number of persistent organic pollutants (POPs) have been associated with the onset of endometriosis, yet the overall set of existing studies remains fairly divergent. In this preliminary case-control study we aimed to assess the potential associations between the internal exposure to POPs and the presence of DIE with or without concurrent OvE...
September 1, 2017: Environment International
https://www.readbyqxmd.com/read/28839333/endometriosis-with-an-aberrant-immunophenotype-challenging-differential-diagnosis-of-glandular-lesions-in-the-pelvic-lymph-nodes
#10
Dita Vlckova, Jiri Lenz, Radek Chvatal, Jan Tihon, Miroslav Kavka, Lucie Uncapher
CASE REPORT: We describe an unusual case of pelvic lymph node endometriosis with an aberrant immunophenotype mimicking metastasis of adenocarcinoma. A 37-year-old patient with a history of invasive cervical adenocarcinoma stage pT1a2 is presented. Due to insufficient loop electrosurgical excision procedure (LEEP) conization, total laparoscopic hysterectomy with pelvic lymphadenectomy was indicated. Intraoperatively, the diagnosis of deep infiltrating endometriosis of parametrial ligament and vesicouterine pouch, endometrioma of the left ovary and Allen Master's syndrome was suspected; the patient had no history or clinical symptoms of endometriosis...
August 24, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28822715/reproductive-outcomes-of-segmented-in-vitro-fertilization-in-patients-diagnosed-with-endometriomas
#11
Kemal Ozgur, Hasan Bulut, Murat Berkkanoglu, Kevin Coetzee
STUDY OBJECTIVE: To assess the impact of ovarian endometriomas on endometrial receptivity in frozen embryo transfers (FET) of segmented in vitro fertilization (IVF) cycles. DESIGN: Retrospective, matched-control study (Canadian Task Force Classification II-2). SETTING: A single, private assisted reproductive technology center. PATIENTS: Thirty patients diagnosed with unilateral or bilateral endometrioma were compared with 60 patients without endometrioma from 1,894 patients who underwent segmented IVF treatment between September 2014 and September 2016...
August 16, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28821472/surgical-findings-and-outcomes-in-premenopausal-breast-cancer-patients-undergoing-oophorectomy-a-multicenter-review-from-the-fellows-pelvic-research-network
#12
Lara F B Harvey, Vandana G Abramson, Jimena Alvarez, Christopher Destephano, Hye-Chun Hur, Katherine Lee, Patricia Mattingly, Beau Park, Carolyn Piszczek, Farinaz Seifi, Mallory Stuparich, Amanda Yunker
STUDY OBJECTIVE: Since publication of the Suppression of Ovarian Function Trial (SOFT) data, some women with premenopausal breast cancer have been recommended to undergo bilateral oophorectomy to facilitate breast cancer treatment with aromatase inhibitors. These women may be at higher risk of occult abdominal pathology than the general population. Our objective is to describe the procedures performed, intra-abdominal findings, and surgical pathology of this population. DESIGN: Multi-center retrospective chart review...
August 15, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28813742/a-case-of-incisional-endometrioma-that-presented-as-an-abdominal-mass
#13
Kelly Landeen, Kristin Wempe, Robert Miller
Although endometriosis is a common condition in women of reproductive age, the incidence of endometrioma in prior surgical incision sites is rare.We present a case of an abdominal wall mass in a female patient with a history of obstetrical surgery. The mass was visualized with ultrasound and computerized tomography, removed by wide excision, and identified via frozen section. This case demonstrates the importance of a thorough surgical and obstetrical history in any woman who presents with an abdominal wall mass...
August 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28807807/in-vitro-fertilization-ivf-success-rates-after-surgically-treated-endometriosis-and-effect-of-time-interval-between-surgery-and-ivf
#14
Basheer AlKudmani, Itai Gat, Danielle Buell, Joveriyah Salman, Khaled Zohni, Clifford Librach, Prati Sharma
STUDY OBJECTIVE: To evaluate the impact of endometriosis staging and endometriomas on IVF outcome and to assess the optimal time interval between laparoscopy and IVF. DESIGN: Retrospective clinical study. DESIGN CLASSIFICATION: II1 SETTING: University affiliated private infertility clinic PATIENTS: 216 infertile patients with endometriosis and 209 infertile patients without endometriosis. INTERVENTIONS: Laparoscopy, In Vitro Fertilization (IVF)...
August 11, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/28760003/surgical-outcomes-of-laparoscopic-endometriosis-surgery-a-6-year-experience
#15
S Alborzi, A Hosseini-Nohadani, T Poordast, Z Shomali
OBJECTIVES: The aim of the present study was to review 6 year experience on the surgical outcomes of laparoscopic endometriosis surgery. METHODS: A cohort study was performed in Shiraz University of Medical Sciences using data from medical records of 1315 cases of patients with endometriosis undergoing laparoscopic surgery with follow-up of 6 to 72 months. RESULTS: This study concerned a cohort of 1315 patients diagnosed with endometriosis operated between April 2010 and April 2016, 1086 (82...
August 31, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28728071/effect-of-dienogest-on-pain-and-ovarian-endometrioma-occurrence-after-laparoscopic-resection-of-uterosacral-ligaments-with-deep-infiltrating-endometriosis
#16
Akiyoshi Yamanaka, Tomonori Hada, Tsuyoshi Matsumoto, Kiyoshi Kanno, Akira Shirane, Shiori Yanai, Saori Nakajima, Keiko Ebisawa, Yoshiaki Ota, Masaaki Andou
OBJECTIVE: To evaluate the effect of dienogest (DNG) in preventing the occurrence of pain and endometriomas after laparoscopic resection of uterosacral ligaments (USLs) with deep infiltrating endometriosis (DIE). STUDY DESIGN: This retrospective analysis included 126 patients who underwent laparoscopic resection of USLs with DIE followed by postoperative administration of DNG or no medication. Every 6 months postoperatively, patients answered questions and underwent ultrasound examination to identify pain and/or endometrioma...
July 11, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28718381/histological-and-immunohistochemical-characterization-of-the-similarity-and-difference-between-ovarian-endometriomas-and-deep-infiltrating-endometriosis
#17
Xishi Liu, Qi Zhang, Sun-Wei Guo
Ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE) have long been recognized to have different histology and, as such, postulated to be 2 separate disease entities. Few studies, however, have attempted to elucidate the causes for their differences. Making use of ectopic endometrial tissue samples from 25 and 20 women with OMA and DIE, respectively, and control endometrial tissue samples from 25 women without endometriosis, we conducted an immunohistochemical analysis to evaluate the expression of a group of carefully chosen markers for epithelial-mesenchymal transition (EMT), fibroblast-to-myofibroblast transdifferentiation (FMT), smooth muscle metaplasia (SMM), fibrosis, vascularity, hormonal receptors, and proteins involved in epigenetic modifications...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28718209/new-knowledge-and-insights-about-the-malignant-transformation-of-endometriosis
#18
Fuminori Taniguchi
Endometriosis may be a definitive risk factor for ovarian cancer, the most fatal gynecological cancer. The ability of endometriosis to transform into malignancy, first described by Dr. Sampson in 1925, is considered a rare occurrence, affecting approximately 1% of ovarian endometriomas. Recently we conducted a retrospective study regarding the malignant transformation of endometriosis in Japanese women. Many studies have reported a consistent correlation between endometriosis and ovarian cancer according to histological subtypes...
July 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28716151/predictive-factors-of-ovarian-carcinoma-for-women-with-ovarian-endometrioma-aged-45%C3%A2-years-and-older-in-china
#19
Zheng-Xing He, Hong-Hui Shi, Qing-Bo Fan, Lan Zhu, Jin-Hua Leng, Da-Wei Sun, Zhan-Fei Li, Keng Shen, Shu Wang, Jing-He Lang
BACKGROUND: To explore the risk factors of endometriosis-associated ovarian cancer (EAOC) in women with ovarian endometriosis (OEM) aged 45 years and above in China. METHODS: This study reviewed the medical records of 1038 women in total who were aged 45 years and above, surgical-pathologically diagnosed with ovarian endometriosis, and were treated at Peking Union Medical College Hospital between December 1996 and December 2016. Histology evaluation was used to determine whether the ovarian endometriosis specimen was with (n = 30) or without (n = 1008) ovarian cancer...
July 17, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28709484/concomitant-female-genital-tuberculosis-and-endometriosis
#20
Jai Bhagwan Sharma, Manu Goyal, Sunesh Kumar, Kallol Kumar Roy, Eshani Sharma, Raksha Arora
AIMS: To demonstrate an association between female genital tuberculosis (FGTB) and endometriosis. METHODS: A total of 16 women who underwent laparoscopy (12 cases) or laparotomy (4 cases) and were found to have female genital tuberculosis and endometriosis were enrolled in this retrospective study. RESULTS: The mean age and parity were 28.2 years and 0.2, respectively. Past history of tuberculosis was present in 75% of the women (pulmonary in 50%)...
July 2017: Indian Journal of Tuberculosis
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