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prolactin and breast cancer

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https://www.readbyqxmd.com/read/29427634/mucuna-pruriens-l-dc-chemo-sensitize-human-breast-cancer-cells-via-downregulation-of-prolactin-mediated-jak2-stat5a-signaling
#1
Sonam Sinha, Sonal Sharma, Jaykant Vora, Heta Shah, Anshu Srivastava, Neeta Shrivastava
ETHNOPHARMACOLOGICAL RELEVANCE: Mucuna pruriens (L.) DC (MP) is an ancient Indian medicinal plant traditionally used to treat Parkinson's disease. L-Dopa (LD), precursor of dopamine is abundantly found in the seeds of MP. L-dopa is a natural inhibitor of prolactin (PRL) hormone which is required to maintain lactation in women but it's over production (hyperprolactinemia) plays critical role in advancement of breast cancer. AIM OF THE STUDY: We aim to examine the pharmacological effect of LD and MP on this hyperprolactinemia associated breast cancer and related signaling for effective management of the disease...
February 7, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29363543/anti-estrogen-therapy-increases-plasticity-and-cancer-stemness-of-prolactin-induced-er%C3%AE-mammary-carcinomas
#2
Michael P Shea, Kathleen A O'Leary, Saja A Fakhraldeen, Vincent Goffin, Andreas Friedl, Kari B Wisinski, Caroline M Alexander, Linda A Schuler
Although anti-estrogen therapies are successful in many patients with estrogen receptor alpha-positive (ERα+) breast cancer, 25-40% fail to respond. Although multiple mechanisms underlie evasion of these treatments, including tumor heterogeneity and drug-resistant cancer stem cells (CSCs), further investigations have been limited by the paucity of preclinical ERα+ tumor models. Here we examined a mouse model of prolactin-induced aggressive ERα+ breast cancer, which mimics the epidemiologic link between prolactin exposure and increased risk for metastatic ERα+ tumors...
January 23, 2018: Cancer Research
https://www.readbyqxmd.com/read/29351761/selective-serotonin-reuptake-inhibitor-use-and-breast-cancer-survival-a-population-based-cohort-study
#3
John Busby, Ken Mills, Shu-Dong Zhang, Fabio Giuseppe Liberante, Chris R Cardwell
BACKGROUND: Nearly 50% of breast cancer patients suffer from depression or anxiety. Selective serotonin reuptake inhibitors (SSRIs), the first-line pharmacological treatment for depression, have been implicated in breast cancer development through increased prolactin levels and tamoxifen metabolism inhibition. Previous studies of breast cancer progression have focused on tamoxifen users, or have been limited by their small sample size and methodology. Therefore, we used UK population-based data to more robustly investigate the association between SSRI use and cancer-specific mortality...
January 19, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29321207/aberrantly-high-expression-of-the-cub-and-zona-pellucida-like-domain-containing-protein-1-cuzd1-in-mammary-epithelium-leads-to-breast-tumorigenesis
#4
Janelle Mapes, Lavanya Anandan, Quanxi Li, Alison Neff, Charles V Clevenger, Indrani C Bagchi, Milan K Bagchi
The peptide hormone prolactin (PRL) and certain members of the epidermal growth factor (EGF) family play central roles in mammary gland development and physiology, and their dysregulation has been implicated in mammary tumorigenesis. Our recent studies have revealed that the CUB and zona pellucida-like domain-containing protein 1 (CUZD1) is a critical factor for PRL-mediated activation of the transcription factor STAT5 in mouse mammary epithelium. CUZD1 controls production of a specific subset of the EGF family growth factors and consequent activation of their receptors...
January 10, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29298280/complete-objective-response-stable-for-5-years-with-the-di-bella-method-of-multiple-metastatic-carcinoma-of-the-breast
#5
Giuseppe Di Bella, Biagio Colori, Rosilde Toscano
Breast cancer is the most common cancer and the leading cause of cancer death among women. Despite all efforts, about 11,939 deaths and 50,000 new diagnoses for breast cancer were estimated among Italian women in 2016. Therefore new approaches are needed to improve the survival and higher remission rates. We present a case of a woman with carcinoma of the breast and multiple metastases after right mastectomy, axillary dissection, repeated cycles of chemo and radiotherapy, and estrogen block. Biological method formulated by Prof...
December 4, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29186352/atm-is-required-for-the-prolactin-induced-hsp90-mediated-increase-in-cellular-viability-and-clonogenic-growth-after-dna-damage
#6
Ödül Karayazi Atici, Anna Urbanska, Sesha Gopal Gopinathan, Florence Boutillon, Vincent Goffin, Carrie S Shemanko
Prolactin acts as a survival factor for breast cancer cells, but the prolactin signaling pathway and the mechanism is unknown. Previously, we identified the master chaperone, heat shock protein 90α (HSP90α), as a prolactin-Janus-Kinase-(JAK2)-signal-transducer-and-activator-of-transcription-5-(STAT5) target gene involved in survival, and here we investigated the role of HSP90 in the mechanism of prolactin-induced viability in response to DNA damage. The ataxia-telangiectasia mutated kinase protein (ATM) plays a critical role in the cellular response to double strand DNA damage...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29124543/determinants-of-prolactin-in-postmenopausal-chinese-women-in-singapore
#7
Tiffany A Katz, Anna H Wu, Frank Z Stanczyk, Renwei Wang, Woon-Puay Koh, Jian-Min Yuan, Steffi Oesterreich, Lesley M Butler
PURPOSE: Mechanistic and observational data together support a role for prolactin in breast cancer development. Determinants of prolactin in Asian populations have not been meaningfully explored, despite the lower risk of breast cancer in Asian populations. METHODS: Determinants of plasma prolactin were evaluated in 442 postmenopausal women enrolled in the Singapore Chinese Health Study, a population-based prospective cohort study. At baseline all cohort members completed an in-person interview that elicited information on diet, menstrual and reproductive history, and lifestyle factors...
January 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29084054/columnar-cell-lesion-and-apocrine-hyperplasia-of-the-breast-is-there-a-common-origin-the-role-of-prolactin-induced-protein
#8
Amedeo Sciarra, Gianluca Lopez, Chiara Corti, Letterio Runza, Giulia Ercoli, Arturo Bonometti, Luca Despini, Concetta Blundo, Donatella Gambini, Nicola Fusco
Noninvasive breast lesions encompass a heterogeneous group of risk indicators and nonobligate precursors of breast cancer, such as apocrine hyperplasia (AH) and columnar cell lesions (CCLs). Given the different expression of ER and ER-regulated genes in AH and CCL, these two alterations are currently considered discrete conditions. However, whether they share early biologic changes is not clear to date. Here, we sought to define the clinicopathologic and immunohistochemical features of a prospective series of combined lesions made up by CCLs and AH forming a continuum within single terminal duct-lobular units...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28977606/subdomain-2-not-the-transmembrane-domain-determines-the-dimerization-partner-of-growth-hormone-receptor-and-prolactin-receptor
#9
Ying Liu, Jing Jiang, Bradford Lepik, Yue Zhang, Kurt R Zinn, Stuart J Frank
Growth hormone receptor (GHR) and prolactin (PRL) receptor (PRLR) are homologous transmembrane class I cytokine receptors. In humans, GH interacts with GHR homodimers or PRLR homodimers and PRL interacts with only PRLR homodimers to promote signaling. In human breast cancer cells endogenously expressing both receptors, GHR and PRLR specifically coimmunoprecipitate. We previously devised a split luciferase complementation assay to study GHR and PRLR assemblages. In this technique, firefly luciferase is split into two fragments (N- and C-terminal fragments of the luciferase), each without enzyme activity and tethered to the tails of two receptors...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28954743/morbidity-and-mortality-in-patients-with-hyperprolactinaemia-the-prolears-study
#10
Enrique Soto-Pedre, Paul J Newey, John S Bevan, Graham P Leese
PURPOSE: High serum prolactin concentrations have been associated with adverse health outcomes in some but not all studies. This study aimed to examine the morbidity and all-cause mortality associated with hyperprolactinaemia. METHODS: A population-based matched cohort study in Tayside (Scotland, UK) from 1988 to 2014 was performed. Record-linkage technology was used to identify patients with hyperprolactinaemia that were compared to an age-sex-matched cohort of patients free of hyperprolactinaemia...
November 2017: Endocrine Connections
https://www.readbyqxmd.com/read/28919264/prolactin-alters-the-mammary-epithelial-hierarchy-increasing-progenitors-and-facilitating-ovarian-steroid-action
#11
Kathleen A O'Leary, Michael P Shea, Stephanie Salituro, Courtney E Blohm, Linda A Schuler
Hormones drive mammary development and function and play critical roles in breast cancer. Epidemiologic studies link prolactin (PRL) to increased risk for aggressive cancers that express estrogen receptor α (ERα). However, in contrast to ovarian steroids, PRL actions on the mammary gland outside of pregnancy are poorly understood. We employed the transgenic NRL-PRL model to examine the effects of PRL alone and with defined estrogen/progesterone exposure on stem/progenitor activity and regulatory networks that drive epithelial differentiation...
October 10, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28915724/c1orf64-is-a-novel-androgen-receptor-target-gene-and-coregulator-that-interacts-with-14-3-3-protein-in-breast-cancer
#12
Ali Naderi
This study investigated the network of genes that are co-expressed with androgen receptor (AR) to discover novel AR targets in breast cancer. Bioinformatics analysis of two datasets from breast cancer cell lines resulted in the identification of an AR-gene signature constituted of 98 genes that highly correlated with AR expression. Notably, C1orf64 showed the highest positive correlation with AR across the datasets with a correlation coefficient (CC) of 0.737. In addition, C1orf64 closely correlated with AR expression in primary and metastatic breast tumors and C1orf64 expression was relatively higher in breast tumors with a lower grade and lobular histology...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28911214/growth-regulation-by-estrogen-in-breast-cancer-1-greb1-is-a-novel-progesterone-responsive-gene-required-for-human-endometrial-stromal-decidualization
#13
Alison J Camden, Maria M Szwarc, Sangappa B Chadchan, Francesco J DeMayo, Bert W O'Malley, John P Lydon, Ramakrishna Kommagani
STUDY QUESTION: Is Growth Regulation by Estrogen in Breast Cancer 1 (GREB1) required for progesterone-driven endometrial stromal cell decidualization? SUMMARY ANSWER: GREB1 is a novel progesterone-responsive gene required for progesterone-driven human endometrial stromal cell (HESC) decidualization. WHAT IS KNOWN ALREADY: Successful establishment of pregnancy requires HESCs to transform from fibroblastic to epithelioid cells in a process called decidualization...
September 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28810691/improvement-of-implantation-potential-in-mouse-blastocysts-derived-from-ivf-by-combined-treatment-with-prolactin-epidermal-growth-factor-and-4-hydroxyestradiol
#14
Miki Takeuchi, Misato Seki, Etsuko Furukawa, Akihito Takahashi, Kyosuke Saito, Mitsuru Kobayashi, Kenji Ezoe, Emiko Fukui, Midori Yoshizawa, Hiromichi Matsumoto
STUDY QUESTION: Can supplementation of medium with prolactin (PRL), epidermal growth factor (EGF) and 4-hydroxyestradiol (4-OH-E2) prior to embryo transfer improve implantation potential in mouse blastocysts derived from IVF? SUMMARY ANSWER: Combined treatment with PRL, EGF and 4-OH-E2 improves mouse blastocyst implantation rates, while alone, each factor is ineffective. WHAT IS KNOWN ALREADY: Blastocyst dormancy during delayed implantation caused by ovariectomy is maintained by continued progesterone treatment in mice, and estrogen injection rapidly activates blastocysts to implantation-induced status in vivo...
August 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28800960/ets-transcription-factor-elf5-induces-lumen-formation-in-a-3d-model-of-mammary-morphogenesis-and-its-expression-is-inhibited-by-jak2-inhibitor-tg101348
#15
Jennifer Chean, Charng-Jui Chen, John E Shively
The loss of expression of a single gene can revert normal tissue to a malignant phenotype. For example, while normal breast has high lumenal expression of CEACAM1, the majority of breast cancers exhibit the early loss of this gene with the concurrent loss of their lumenal phenotype. MCF7 cells that lack CEACAM1 expression and fail to form lumena in 3D culture, regain the normal phenotype when transfected with CEACAM1. In order to probe the mechanism of this gain of function, we treated these cells with the clinically relevant Jak2 inhibitor TG101348 (TG), expecting that disruption of the prolactin receptor signaling pathway would interfere with the positive effects of transfection of MCF7 cells with CEACAM1...
October 1, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28717404/physical-activity-does-not-alter-prolactin-levels-in-post-menopausal-women-results-from-a-dose-response-randomized-controlled-trial
#16
Darren R Brenner, Yibing Ruan, Andria R Morielli, Kerry S Courneya, Christine M Friedenreich
BACKGROUND: Increased circulating levels of prolactin have been associated with increased risk of both in situ and invasive breast cancer. We investigated whether or not physical activity had a dose-response effect in lowering plasma levels of prolactin in postmenopausal women. METHODS: Four hundred previously inactive but healthy postmenopausal women aged 50-74 years of age were randomized to 150 or 300 min per week of aerobic physical activity in a year-long intervention...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28674764/a-pilot-study-of-cabergoline-for-the-treatment-of-metastatic-breast-cancer
#17
Ricardo Costa, C A Santa-Maria, D M Scholtens, S Jain, L Flaum, W J Gradishar, C V Clevenger, V G Kaklamani
PURPOSE: The prolactin (PRL) receptor is over-expressed in breast cancer, and pre-clinical data indicate that it contributes to breast oncogenesis. Cabergoline is a potent dopamine receptor agonist of D2 receptors and has a direct inhibitory effect on pituitary PRL secretion. METHODS: A phase II study of cabergoline in patients with metastatic breast cancer was conducted. The primary end point of the study was to determine the clinical benefit rate (CBR) at 2 months...
July 3, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28673861/cpsf6-is-a-clinically-relevant-breast-cancer-vulnerability-target-role-of-cpsf6-in-breast-cancer
#18
Najat Binothman, Ibrahim Y Hachim, Jean-Jacques Lebrun, Suhad Ali
Breast cancer represents a major health challenge. The majority of breast cancer deaths are due to cancer progression/recurrence for which no efficient therapies exist. Aggressive breast cancers are characterized by loss of cellular differentiation. Defining molecular mechanisms/targets contributing to cancer aggressiveness is needed to guide the design of new screening and targeted treatments. Here, we describe a novel tumor promoting function for the Cleavage and Polyadenylation Factor-6 (CPSF6). Importantly, aggressive breast cancer cells of luminal B, HER2-overexpressing and triple negative subtypes show dependency on CPSF6 for viability and tumorigenic capacity...
July 2017: EBioMedicine
https://www.readbyqxmd.com/read/28634940/3d-primary-culture-model-to-study-human-mammary-development
#19
Daniel H Miller, Ethan S Sokol, Piyush B Gupta
We present a protocol for expanding human mammary tissues from primary patient-derived cells in three-dimensional (3D) cultures. The primary epithelial cells are seeded into 3D hydrogels with defined components, which include both proteins and carbohydrates present in mammary tissue. Over a span of 10-14 days, the seeded cells form mammary tissues with complex ductal-lobular topologies and include luminal and basal cells in the correct orientation, together with cells that stain positively for stem cell markers...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28571002/c1orf64-is-a-novel-androgen-receptor-target-gene-and-coregulator-that-interacts-with-14-3-3-protein-in-breast-cancer
#20
Ali Naderi
This study investigated the network of genes that are co-expressed with androgen receptor (AR) to discover novel AR targets in breast cancer. Bioinformatics analysis of two datasets from breast cancer cell lines resulted in the identification of an AR-gene signature constituted of 98 genes that highly correlated with AR expression. Notably, C1orf64 showed the highest positive correlation with AR across the datasets with a correlation coefficient (CC) of 0.737. In addition, C1orf64 closely correlated with AR expression in primary and metastatic breast tumors and C1orf64 expression was relatively higher in breast tumors with a lower grade and lobular histology...
May 11, 2017: Oncotarget
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