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https://www.readbyqxmd.com/read/29773910/the-l-type-calcium-channel-blocker-isradipine-attenuates-cue-induced-cocaine-seeking-by-enhancing-dopaminergic-activity-in-the-ventral-tegmental-area-to-nucleus-accumbens-pathway
#1
Nii A Addy, Eric J Nunes, Shannon M Hughley, Keri M Small, Sarah J Baracz, Joshua L Haight, Anjali M Rajadhyaksha
Previous preclinical and clinical investigations have focused on the L-type calcium channel (LTCC) as a potential therapeutic target for substance abuse. While some clinical studies have examined the ability of LTCC blockers to alter cocaine's subjective effects, very few LTCC studies have examined cocaine relapse. Here, we examined whether ventral tegmental area (VTA)-specific or systemic administration of the LTCC inhibitor, isradipine, altered cocaine-seeking behavior in a rat model. Male Sprague-Dawley rats first received 10 days of cocaine self-administration training (2 h sessions), where active lever depression resulted in delivery of a ∼0...
May 3, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29773518/developmental-trajectories-of-brain-maturation-and-behavior-relevance-to-major-mental-illnesses
#2
REVIEW
Sedona Lockhart, Akira Sawa, Minae Niwa
Adverse events in childhood and adolescence, such as social neglect or drug abuse, are known to lead to behavioral changes in young adulthood. This is particularly true for the subset of people who are intrinsically more vulnerable to stressful conditions. Yet the underlying mechanisms for such developmental trajectory from early life insult to aberrant adult behavior remains elusive. Adolescence is a period of dynamic physiological, psychological, and behavioral changes, encompassing a distinct neurodevelopmental stage called the 'critical period'...
May 3, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29772497/the-role-of-the-vasopressin-system-and-dopamine-d1-receptors-in-the-effects-of-social-housing-condition-on-morphine-reward
#3
M L Shawn Bates, Rebeca S Hofford, Michael A Emery, Paul J Wellman, Shoshana Eitan
BACKGROUND: The association with opioid-abusing individuals or even the perception of opioid abuse by peers are risk factors for the initiation and escalation of abuse. Similarly, we demonstrated that morphine-treated animals housed with only morphine-treated animals (referred to as morphine only) acquire morphine conditioned place-preference (CPP) more readily than morphine-treated animals housed with drug-naïve animals (referred to as morphine cage-mates). However, the molecular mechanisms underlying these effects are still elusive...
April 22, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29772468/understanding-child-protection-decisions-involving-parents-with-mental-illness-and-substance-abuse
#4
Joseph N Roscoe, Bridgette Lery, Jaclyn E Chambers
Among children investigated for maltreatment, those with parents experiencing mental illness or substance abuse are more likely to be placed out-of-home; however, little is known about why these children are at greater risk. Using a sample of 2488 Structured Decision Making® assessments administered in San Francisco county from 2011 to 2015, we identified a profile of safety threats that accounts for why workers are more likely to determine children of parents with mental illness and/or substance abuse unsafe in the home...
May 14, 2018: Child Abuse & Neglect
https://www.readbyqxmd.com/read/29772331/surgical-treatment-of-a-high-flow-femoro-femoral-arteriovenous-fistula-in-an-intravenous-drug-abuser
#5
Pietro Rossetti, Paolo Perini, Alessandro Ucci, Gaetano Carolla, Antonio Freyrie, Roberto Quintavalla
OBJECTIVE: To report the surgical treatment of a high-flow femoro-femoral arteriovenous fistula (AVF), a rare complication of intravenous drug abuse. CASE REPORT: A 36-year-old woman with history of intravenous heroin and cocaine abuse presented with right lower limb oedema, inguinal bruit and heart failure. Duplex ultrasound examination and CT-angiography showed a large, high-flow AVF involving the common femoral vein and the superficial femoral artery, associated with thrombosis of the great saphenous vein and an important inflammation in the right groin, without active bleeding...
May 14, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29771745/national-institute-on-drug-abuse-international-program-improving-opioid-use-disorder-treatment-through-international-research-training
#6
Steven W Gust, Judy McCormally
PURPOSE OF REVIEW: For more than 25 years, the National Institute on Drug Abuse (NIDA) has supported research-training programs, establishing a global research network and expanding the knowledge base on substance use disorders. International research to inform approaches to opioid addiction is particularly important and relevant to the United States, where opioid misuse, addiction, and overdose constitute an emerging public health crisis. This article summarizes the NIDA International Program and illustrates its impact by reviewing recent articles about treatment approaches for opioid use disorders (OUD)...
May 15, 2018: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29771559/body-mass-index-across-adolescence-and-substance-use-problems-in-early-adulthood
#7
Ashley N Gearhardt, Rebecca Waller, Jennifer M Jester, Luke W Hyde, Robert A Zucker
Excessive substance use and obesity are underpinned by a number of shared risk factors (e.g., reward dysfunction, impulsivity). Food and drugs of abuse engage similar reward-related neural circuitry and the food-drug competition hypothesis proposes that excess consumption of food may diminish desire for drugs of abuse by competing for neural receptors associated with reward and motivation. Adolescence is a high-risk period for both increased substance use and excessive weight gain. In the present study, the authors tested whether, consistent with the food-drug competition hypothesis, elevated body mass index (BMI) across adolescence predicted fewer substance use problems in young adulthood...
May 2018: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/29770212/adolescent-thc-exposure-does-not-sensitize-conditioned-place-preferences-to-subthreshold-d-amphetamine-in-male-and-female-rats
#8
Robin J Keeley, Cameron Bye, Jan Trow, Robert J McDonald
The acute effects of marijuana consumption on brain physiology and behaviour are well documented, but the long-term effects of its chronic use are less well known. Chronic marijuana use during adolescence is of increased interest, given that the majority of individuals first use marijuana during this developmental stage , and  adolescent marijuana use is thought to increase the susceptibility to abusing other drugs when exposed later in life. It is possible that marijuana use during critical periods in adolescence could lead to increased sensitivity to other drugs of abuse later on...
2018: F1000Research
https://www.readbyqxmd.com/read/29769185/unusual-case-of-iron-overload-with-cancer-mimicking-abdominal-splenosis
#9
Giacomo Marchi, Giacomo Avesani, Alberto Zamò, Domenico Girelli
A 48-year-old man, former alcohol abuser and drug addicted, was referred to our tertiary referral centre for iron disorders because of marked hyperferritinaemia. His clinical history revealed chronic hepatitis C, ß-thalassaemia trait and post-traumatic splenectomy at age of 22. MRI-estimated liver iron content was markedly elevated, while first-line genetic test for haemochromatosis was negative. Alpha-fetoprotein was increased but liver ultrasonography did not reveal focal liver lesions. Multiphasic contrast-enhanced CT confirmed this result but showed two abdominal masses (diameter of 9 cm and 7 cm, respectively) among bowel loops, strongly suspicious for cancer...
May 16, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29768070/web-based-intervention-to-reduce-substance-abuse-and-depression-a-three-arm-randomized-trial-in-mexico
#10
Marcela Tiburcio, Ma Asunción Lara, Nora Martínez, Morise Fernández, Araceli Aguilar
BACKGROUND: Web-based cognitive-behavioral interventions to reduce substance use can be a useful low-cost treatment for a large number of people, and an attractive option in countries where a greater availability of treatment is needed. OBJECTIVE: To evaluate the feasibility and initial effectiveness of a web-based cognitive-behavioral intervention for the reduction of substance use and depression compared with treatment as usual, with and without a printed self-help manual...
May 16, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29766293/nmda-receptor-subunits-change-in-the-prefrontal-cortex-of-pure-opioid-and-multi-drug-abusers-a-post-mortem-study
#11
Hamidreza Daneshparvar, Mitra-Sadat Sadat-Shirazi, Monir Fekri, Solmaz Khalifeh, Ali Ziaie, Nasrin Esfahanizadeh, Nasim Vousooghi, Mohammad-Reza Zarrindast
Addiction is a chronic relapsing disorder and is one of the most important issues in the world. Changing the level of neurotransmitters and the activities of their receptors, play a major role in the pathophysiology of substance abuse disorders. It is well-established that N-methyl-D-aspartate receptors (NMDARs) play a significant role in the molecular basis of addiction. NMDAR has two obligatory GluN1 and two regionally localized GluN2 subunits. This study investigated changes in the protein level of GluN1, GluN2A, and GluN2B in the prefrontal cortex of drug abusers...
May 16, 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/29766147/the-non-preventive-effects-of-human-menopausal-gonadotropins-on-ovarian-tissues-in-nandrolone-decanoate-treated-female-rats-a-histochemical-and-ultra-structural-study
#12
Fakhroddin Mesbah, Hossein Bordbar, Tahereh Talaei Khozani, Farzaneh Dehghani, Hossein Mirkhani
Background: The follicular growth and development may be affected by abused drugs. Nandrolone decanoate (ND) as an anabolic androgenic steroid can damage the morphological and functional features of the ovary and may lead to reproductive failure. Objective: This study was designed to evaluate the effects of synchronized and non-synchronized administration of Human Menopausal Gonadotropins (hMG) with ND on ovarian tissue and level of sex hormones in the adult female rat...
March 2018: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/29766143/when-should-screening-of-pediatric-trauma-patients-for-adult-behaviors-start
#13
Adrian A Maung, Robert D Becher, Kevin M Schuster, Kimberly A Davis
Background: Care of patients with trauma is not only limited to the sustained physical injuries but also requires addressing social issues, such as substance abuse and interpersonal violence, which are responsible for trauma-related recidivism. This study investigates whether there are age-related variations in these problematic social behaviors to analyze whether there is an age cut-off at which point adolescents should be screened for adult social behaviors. Methods: Retrospective review of patients with trauma aged 12-21 admitted to an urban Level 1 adult and pediatric trauma center between February 2013 and April 2016...
2018: Trauma surgery & acute care open
https://www.readbyqxmd.com/read/29765983/a-clinical-study-of-toxication-caused-by-carbamazepine-abuse-in-adolescents
#14
Wei Xu, Yu-Lin Chen, Ying Zhao, Li-Jie Wang, Jiu-Jun Li, Chun-Feng Liu
Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in the adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity in Chinese adolescents. The median dose of carbamazepine resulting in overdose was 2,000 mg (800-5,000). Patients were largely from urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by parents...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29762764/insomnia-as-a-path-to-alcoholism-tolerance-development-and-dose-escalation
#15
Timothy Roehrs, Thomas Roth
Study Objectives: To assess the risks associated with the use of alcohol as a "sleep aid", we evaluated tolerance development to pre-sleep ethanol's sedative-hypnotic effects, subsequent ethanol dose escalation, and changes in mood and ethanol "liking". Methods: Volunteers, 21-55 yrs old, with insomnia in otherwise good medical and psychiatric health and no history of alcoholism or drug abuse participated. In experiment 1 (n=24) 0.0, 0.3, or 0...
May 12, 2018: Sleep
https://www.readbyqxmd.com/read/29762757/how-are-real-time-opioid-prescribing-cognitions-by-emergency-providers-influenced-by-reviewing-the-state-prescription-drug-monitoring-program
#16
Aaron Landau, Michael Lynch, Clifton Callaway, Brian Suffoletto
Objective: To understand how real-time opioid prescribing cognitions by emergency medicine (EM) providers are influenced by review of the state prescription drug monitoring program (PDMP). Methods: We collected prospective data from a convenience sample of 103 patient encounters for pain from 23 unique EM providers. After seeing the patient, before and immediately after reviewing the PDMP, EM providers answered how much they thought "the patient need[ed] an opioid to help manage their pain?", how concerned they were "about drug abuse and/or diversion?", and whether they planned to prescribe an opioid (yes/no)...
May 11, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29761753/against-the-stream-religion-and-mental-health-the-case-for-the-inclusion-of-religion-and-spirituality-into-psychiatric-care
#17
Simon Dein
This paper argues for the inclusion of religion and spirituality in psychiatric care. After discussing the antagonism of psychiatrists and psychologists to religion, I present a critical overview of studies examining the relationships between spirituality, religion and diverse aspects of mental health: depression, suicide, anxiety, delinquency, drug abuse and schizophrenia. The need to assesses the impact of religion in different faith groups is discussed. Measures of religious coping, both positive and negative, may provide a more accurate portrayal as to how individuals deploy religion in their lives than global measures such as belief and attendance...
June 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29761479/antidepressants-for-insomnia-in-adults
#18
REVIEW
Hazel Everitt, David S Baldwin, Beth Stuart, Gosia Lipinska, Andrew Mayers, Andrea L Malizia, Christopher Cf Manson, Sue Wilson
BACKGROUND: Insomnia disorder is a subjective condition of unsatisfactory sleep (e.g. sleep onset, maintenance, early waking, impairment of daytime functioning). Insomnia disorder impairs quality of life and is associated with an increased risk of physical and mental health problems including anxiety, depression, drug and alcohol abuse, and increased health service use. hypnotic medications (e.g. benzodiazepines and 'Z' drugs) are licensed for sleep promotion, but can induce tolerance and dependence, although many people remain on long-term treatment...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29761343/role-of-exogenous-progesterone-in-the-treatment-of-men-and-women-with-substance-use-disorders-a-narrative-review
#19
REVIEW
MacKenzie R Peltier, Mehmet Sofuoglu
Substance use disorders (SUDs) remain problematic as many individuals are untreated or do not benefit from the currently available interventions. Thus, there is an urgent need to develop novel pharmacological interventions to treat SUDs. Evidence suggests that the female sex hormone, progesterone, attenuates the craving for and the euphoric effects of drugs of abuse. Research to date has demonstrated that progesterone may modulate responses to drugs of abuse and may have utility as a novel treatment for SUDs...
May 14, 2018: CNS Drugs
https://www.readbyqxmd.com/read/29760674/validation-of-a-spanish-questionnaire-on-mobile-phone-abuse
#20
María A Olivencia-Carrión, Isabel Ramírez-Uclés, Pablo Holgado-Tello, Francisca López-Torrecillas
Mobile phone addiction has attracted much attention recently and is showing similarity to other substance use disorders. Because no studies on mobile phone addiction had yet been conducted in Spain, we developed and validated a questionnaire (Cuestionario de Abuso del Teléfono Móvil, ATeMo) to measure mobile phone abuse among young adults in Spanish. The ATeMo questionnaire was designed based on relevant DSM-5 diagnostic criteria and included craving as a diagnostic symptom. Using stratified sampling, the ATeMo questionnaire was administered to 856 students (mean age 21, 62% women)...
2018: Frontiers in Psychology
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