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Cinnamaldehyde

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https://www.readbyqxmd.com/read/29329804/a-rapid-and-sensitive-fluorometric-method-for-determination-of-aldehyde-oxidase-activity
#1
Nancy Apenova, Hui Peng, Markus Hecker, Markus Brinkmann
Previous research has characterized the important role of aldehyde oxidases (AOX) in biotransformation of N-heterocyclic therapeutic drugs and environmental contaminants in mammals. Research pertaining to AOX activity in non-mammalian vertebrates, however, is scarce, despite its biological role as a potentially important metabolic pathway for xenobiotics. One of the limiting factors of research on AOX is that available photometric methods are relatively insensitive, limited in throughput, and prone to cross-reactivity from other enzymes...
January 9, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29325862/antibacterial-effects-of-cinnamon-cinnamomum-zeylanicum-bark-essential-oil-on-porphyromonas-gingivalis
#2
Yue Wang, Yi Zhang, Yan-Qin Shi, Xian-Hua Pan, Yan-Hua Lu, Ping Cao
The objective of this study was to investigate the antibacterial effects of cinnamon (Cinnamomum zeylanicum) bark essential oil (CBEO) and its principal constituent cinnamaldehyde against Porphyromonas gingivalis and to elucidate the antibacterial mechanism. GC-MS analysis showed that cinnamaldehyde was the major constituent in CBEO (57.97%). The minimum inhibition concentrations (MICs) of CBEO and cinnamaldehyde were 6.25 μg/mL and 2.5 μM for P. gingivalis, respectively. Nucleic acid and protein leakage was observed with increasing concentrations of CBEO and cinnamaldehyde...
January 8, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29319361/cinnamon-cinnamomum-zeylanicum-as-an-antidote-or-a-protective-agent-against-natural-or-chemical-toxicities-a-review
#3
Mahyar Dorri, Shirin Hashemitabar, Hossein Hosseinzadeh
Cinnamon (Cinnamomum zeylanicum, Lauraceae) is a food additive greatly used for its taste. However, recently this medicinal plant has been brought to attention due to its medical effects. Cinnamon has constituents such as cinnamaldehyde and cinnamic acid that offers some health benefits including antioxidant and free-radical scavenging properties, lowering of blood glucose, anti-cholesterolemic, analgesic, antimicrobial, anti-inflammatory, anti-yeast, anti-secretagogue, and anti-gastric ulcer effects. This review summarizes various in vitro and animal studies on the protective effects of cinnamon against natural and chemical toxins...
January 10, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29306845/determination-of-membrane-disruption-and-genomic-dna-binding-of-cinnamaldehyde-to-escherichia-coli-by-use-of-microbiological-and-spectroscopic-techniques
#4
Tian-Fu He, Zhi-Hong Zhang, Xin-An Zeng, Lang-Hong Wang, Charles S Brennan
This work was aimed to investigate the antibacterial action of cinnamaldehyde (CIN) against Escherichia coli ATCC 8735 (E. coli) based on membrane fatty acid composition analysis, alterations of permeability and cell morphology as well as interaction with genomic DNA. Analysis of membrane fatty acids using gas chromatography-mass spectrometry (GC-MS) revealed that the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) were the major fatty acids in plasmic membrane, and their levels were significantly changed after exposure of E...
November 10, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29277026/the-cinnamyl-alcohol-dehydrogenase-family-in-flax-differentiation-during-plant-growth-and-under-stress-conditions
#5
Marta Preisner, Wioleta Wojtasik, Kamil Kostyn, Aleksandra Boba, Tadeusz Czuj, Jan Szopa, Anna Kulma
Cinnamyl alcohol dehydrogenase (CAD), which catalyzes the reduction of cinnamaldehydes to their alcohol derivatives, is represented by a large family of proteins. The aim of the study was to identify the CAD isoforms in flax (Linum usitatissimum L.) - LuCADs - and to determine their specificity to enhance knowledge of the mechanisms controlling cell wall lignification in flax under environmental stresses. On the basis of genome-wide analysis, we identified 15 isoforms (one in two copies) belonging to three major classes of the CAD protein family...
December 13, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29258915/cinnamon-a-promising-prospect-towards-alzheimer-s-disease
#6
REVIEW
Saeideh Momtaz, Shokoufeh Hassani, Fazlullah Khan, Mojtaba Ziaee, Mohammad Abdollahi
Over the last decades, an exponential increase of efforts concerning the treatment of Alzheimer's disease (AD) has been practiced. Phytochemicals preparations have a millenary background to combat various pathological conditions. Various cinnamon species and their biologically active ingredients have renewed the interest towards the treatment of patients with mild-to-moderate AD through the inhibition of tau protein aggregation and prevention of the formation and accumulation of amyloid-β peptides into the neurotoxic oligomeric inclusions, both of which are considered to be the AD trademarks...
December 16, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29244848/surface-modified-nanoparticles-as-anti-biofilm-filler-for-dental-polymers
#7
Nathan Zaltsman, Andrei C Ionescu, Ervin I Weiss, Eugenio Brambilla, Shaul Beyth, Nurit Beyth
The objective of the study was to synthesis silica nanoparticles modified with (i) a tertiary amine bearing two t-cinnamaldehyde substituents or (ii) dimethyl-octyl ammonium, alongside the well-studied quaternary ammonium polyethyleneimine nanoparticles. These were to be evaluated for their chemical and mechanical properties, as well for antibacterial and antibiofilm activity. Samples were incorporated in commercial dental resin material and the degree of monomer conversion, mechanical strength, and water contact angle were tested to characterize the effect of the nanoparticles on resin material...
2017: PloS One
https://www.readbyqxmd.com/read/29244766/antifungal-activity-of-ramulus-cinnamomi-explored-by-%C3%A2-h-nmr-based-metabolomics-approach
#8
Chunpeng Wan, Pei Li, Chuying Chen, Xuan Peng, Mingxi Li, Ming Chen, Junsong Wang, Jinyin Chen
A ¹H nuclear magnetic resonance (NMR)-based approach to metabolomics combined bioassay was used to elucidate the antifungal activity of cinnamaldehyde (the main active compound of Ramulus cinnamomi) isolated from Ramulus cinnamomi (RC). Orthogonal signal correction partial least-squares discriminant analysis (OSC-PLS-DA) of NMR data was constructed to analyze all the P. italicum data acquired from the control and treatment groups at 4, 8, and 12 h. Metabolic profiles disclosed metabolic changes that were related to the antifungal effects of cinnamaldehyde against P...
December 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29234401/trans-cinnamaldehyde-inhibits-microglial-activation-and-improves-neuronal-survival-against-neuroinflammation-in-bv2-microglial-cells-with-lipopolysaccharide-stimulation
#9
Yan Fu, Pin Yang, Yang Zhao, Liqing Zhang, Zhangang Zhang, Xianwen Dong, Zhongping Wu, Ying Xu, Yongjun Chen
Background: Microglial activation contributes to neuroinflammation and neuronal damage in neurodegenerative disorders including Alzheimer's and Parkinson's diseases. It has been suggested that neurodegenerative disorders may be improved if neuroinflammation can be controlled. trans-cinnamaldehyde (TCA) isolated from the stem bark of Cinnamomum cassia possesses potent anti-inflammatory capability; we thus tested whether TCA presents neuroprotective effects on improving neuronal survival by inhibiting neuroinflammatory responses in BV2 microglial cells...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29231854/nisin-in-combination-with-cinnamaldehyde-and-edta-to-control-growth-of-escherichia-coli-strains-of-swine-origin
#10
Des Field, Inès Baghou, Mary C Rea, Gillian E Gardiner, R Paul Ross, Colin Hill
Post-weaning diarrhoea (PWD) due to enterotoxigenic Escherichia coli (ETEC) is an economically important disease in pig production worldwide. Although antibiotics have contributed significantly to mitigate the economic losses caused by PWD, there is major concern over the increased incidence of antimicrobial resistance among bacteria isolated from pigs. Consequently, suitable alternatives that are safe and effective are urgently required. Many naturally occurring compounds, including the antimicrobial peptide nisin and a number of plant essential oils, have been widely studied and are reported to be effective as antimicrobial agents against pathogenic microorganisms...
December 12, 2017: Antibiotics
https://www.readbyqxmd.com/read/29214107/diet-and-rosacea-the-role-of-dietary-change-in-the-management-of-rosacea
#11
REVIEW
Emma Weiss, Rajani Katta
Dietary change may play a role in the therapy of rosacea. Certain foods and beverages may act as "triggers" for rosacea exacerbations. These may be divided into heat-related, alcohol-related, capsaicin-related, and cinnamaldehyde-related. One potential pathogenic mechanism may be via the activation of transient receptor potential cation channels, which result in neurogenic vasodilatation. Further research is needed on the role of the gut skin connection in rosacea. Epidemiologic studies suggest that patients with rosacea have a higher prevalence of gastrointestinal disease, and one study reported improvement in rosacea following successful treatment of small intestinal bacterial overgrowth...
October 2017: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/29198120/in-situ-interfacial-conjugation-of-chitosan-with-cinnamaldehyde-during-homogenization-improves-the-formation-and-stability-of-chitosan-stabilized-emulsions
#12
Huanle Chen, David Julian McClements, Enmin Chen, Shilin Liu, Bin Li, Yan Li
The emulsifying properties of a natural cationic polysaccharide (chitosan) were improved by in situ conjugation with a natural essential oil (cinnamaldehyde, CA) during homogenization. In the absence of CA, chitosan-coated medium chain triglyceride (MCT) droplets were highly susceptible to creaming and coalescence at pH values ranging from 1 to 6.5. However, incorporation of relatively low levels of CA in the oil phase greatly improved the formation and stability of the oil-in-water emulsions. These effects were attributed to two main factors: (i) covalent binding of lipophilic CA moieties to hydrophilic chitosan chains leading to conjugates with good surface-activity; (ii) interfacial cross-linking of adsorbed chitosan layers by CA leading to the formation of a rigid polymeric coating around the lipid droplets that improved their stability against coalescence...
December 4, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29195934/photocrosslinker-technology-an-antimicrobial-efficacy-of-cinnamaldehyde-cross-linked-low-density-polyethylene-cin-c-ldpe-as-a-novel-food-wrapper
#13
H M Manukumar, S Umesha
In recent years much attention has been devoted to active packaging technologies that offer new opportunities for the food industry and food preservation. The spoilage of food products during post process handling leads to food contamination and causes life-threatening food-borne illness. The methicillin-resistant Staphylococcus aureus (MRSA) 090 is one of the food-borne pathogens associated with food poisoning that leads to an outbreak of perilous human infections worldwide. The development of resistance in bacteria and diffusion of coated synthetic preservatives into food are the major problem in food packaging industries...
December 2017: Food Research International
https://www.readbyqxmd.com/read/29186481/optimisation-of-trans-cinnamic-acid-and-hydrocinnamyl-alcohol-production-with-recombinant-saccharomyces-cerevisiae-and-identification-of-cinnamyl-methyl-ketone-as-a-by-product
#14
Manuela Gottardi, Peter Grün, Helge B Bode, Thomas Hoffmann, Wilfried Schwab, Mislav Oreb, Eckhard Boles
Trans-cinnamic acid (tCA) and hydrocinnamyl alcohol (HcinOH) are valuable aromatic compounds with applications in the flavour, fragrance and cosmetic industry. They can be produced with recombinant yeasts from sugars via phenylalanine after expression of a phenylalanine ammonia lyase (PAL) and an aryl carboxylic acid reductase (ACAR). Here we show that in Saccharomyces cerevisiae a PAL enzyme from the bacterium Photorhabdus luminescens was superior to a previously used plant PAL enzyme for the production of tCA...
November 23, 2017: FEMS Yeast Research
https://www.readbyqxmd.com/read/29163441/antifungal-and-anti-biofilm-activity-of-essential-oil-active-components-against-cryptococcus-neoformans-and-cryptococcus-laurentii
#15
Poonam Kumari, Rutusmita Mishra, Neha Arora, Apurva Chatrath, Rashmi Gangwar, Partha Roy, Ramasare Prasad
Cryptococcosis is an emerging and recalcitrant systemic infection occurring in immunocompromised patients. This invasive fungal infection is difficult to treat due to the ability of Cryptococcus neoformans and Cryptococcus laurentii to form biofilms resistant to standard antifungal treatment. The toxicity concern of these drugs has stimulated the search for natural therapeutic alternatives. Essential oil and their active components (EO-ACs) have shown to possess the variety of biological and pharmacological properties...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29155570/chemistry-antimicrobial-mechanisms-and-antibiotic-activities-of-cinnamaldehyde-against-pathogenic-bacteria-in-animal-feeds-and-human-foods
#16
Mendel Friedman
Cinnamaldehyde is a major constituent of cinnamon essential oils produced by aromatic cinnamon plants. This compound has been reported to exhibit antimicrobial properties in vitro in laboratory media and in animal feeds and human foods contaminated with disease-causing bacteria including Bacillus cereus, Campylobacter jejuni, Clostridium perfringens, Escherichia coli, Listeria monocytogenes, and Salmonella enterica. This integrated review surveys and interprets our current knowledge of the chemistry, analysis, safety, mechanism of action, and antibiotic activities of cinnamaldehyde in food animal (cattle, lambs, calves, pigs, poultry) diets and in widely consumed liquid (apple, carrot, tomato, and watermelon juices, milk) and solid foods...
December 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29146372/interactions-of-cinnamaldehyde-and-its-metabolite-cinnamic-acid-with-human-serum-albumin-and-interference-of-other-food-additives
#17
Qiaomei Sun, Hongqin Yang, Peixiao Tang, Jiuyang Liu, Wan Wang, Hui Li
Considering the adverse effect of food additives on humans, thorough research of their physiological effects at the molecular level is important. The interactions of cinnamaldehyde (CNMA), a food perfume, and its major metabolite cinnamic acid (CA) with human serum albumin (HSA) were examined by multiple-spectroscopies. NMR analysis revealed CNMA and CA both bound to HSA, and STD-NMR experiments established CNMA and CA primarily interacted with site I and site II of HSA, respectively. The ligands caused strong quenching of HSA fluorescence through a static quenching mechanism, with hydrophobic and electrostatic interaction between CNMA/CA and HSA, respectively...
March 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29146242/acid-activatable-oxidative-stress-inducing-polysaccharide-nanoparticles-for-anticancer-therapy
#18
Wooyoung Yoo, Donghyuck Yoo, Eunmi Hong, Eunkyeong Jung, Yebin Go, Berwin Singh, Gilson Khang, Dongwon Lee
Drug delivery systems have been extensively developed to enhance the therapeutic efficacy of drugs by altering their pharmacokinetics and biodistribution. However, the use of high quantities of drug delivery systems can cause toxicity due to their poor metabolism and elimination. In this study, we developed polysaccharide-based drug delivery systems which exert potent therapeutic effects and could display synergistic therapeutic effects with drug payloads, leading to dose reduction. Cinnamaldehyde, a major component of cinnamon is known to induce anticancer activity by generating ROS (reactive oxygen species)...
November 13, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29145172/volatiles-from-cinnamomum-cassia-buds
#19
Daniel Sandner, Ulrich Krings, Ralf G Berger
While the chemical composition of leaf and stem bark essential oils of the Chinese cinnamon, Cinnamomum cassia (L.) J. Presl, has been well investigated, little is known about the volatilom of its buds, which appeared recently on German markets. Soxhlet extracts of the commercial samples were prepared, fractionated using silica gel and characterised by gas chromatography-flame ionisation detector (GC-FID) for semi-quantification, by gas chromatography-mass spectrometry (GC-MS) for identification and by GC-FID/olfactometry for sensory evaluation...
November 16, 2017: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29142428/in-vitro-protoscolicidal-effects-of-cinnamomum-zeylanicum-essential-oil-and-its-toxicity-in-mice
#20
Hossein Mahmoudvand, Hormoz Mahmoudvand, Razieh Tavakoli Oliaee, Amir Tavakoli Kareshk, Seyed Reza Mirbadie, Mohammad Reza Aflatoonian
Background: This study investigates the scolicidal effects of Cinnamomum zeylanicum essential oil against the protoscoleces of hydatid cysts and its toxicity in the mice model. Materials and Methods: Gas chromatography/mass spectroscopy analyses were used to identify the constituents of essential oil. Protoscoleces were treated with different concentrations of the essential oil (6.25-100 µL/mL) in each test tube for 5-30 min. The viability of protoscoleces was confirmed using eosin exclusion test (0...
October 2017: Pharmacognosy Magazine
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