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Cinnamaldehyde

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https://www.readbyqxmd.com/read/28440548/contact-sensitizers-trigger-human-cd1-autoreactive-t-cell-responses
#1
Richard J Betts, Adrijana Perkovic, Subhashree Mahapatra, Aurélia Del Bufalo, Kaddy Camara, Amy R Howell, Silvia Martinozzi Teissier, Gennaro De Libero, Lucia Mori
Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Exposure of human antigen-presenting cells such as monocyte-derived dendritic cells and THP-1 cells to the prototypical contact sensitizer dinitrochlorobenzene potentiated the response of CD1a- and CD1d-autoreactive T cells, which released a vast array of cytokines in a CD1- and TCR-dependent manner...
April 25, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28435717/a-cinnamaldehyde-schiff-base-of-s-4-methyl-benz-yl-di-thio-carbazate-crystal-structure-hirshfeld-surface-analysis-and-computational-study
#2
Enis Nadia Md Yusof, Mohamed I M Tahir, Thahira B S A Ravoof, Sang Loon Tan, Edward R T Tiekink
The title di-thio-carbazate ester (I), C18H18N2S2 [systematic name: (E)-4-methyl-benzyl 2-[(E)-3-phenyl-allyl-idene]hydrazinecarbodi-thio-ate, comprises an almost planar central CN2S2 residue [r.m.s. deviation = 0.0131 Å]. The methyl-ene(tolyl-4) group forms a dihedral angle of 72.25 (4)° with the best plane through the remaining non-hydrogen atoms [r.m.s. deviation = 0.0586 Å] so the mol-ecule approximates mirror symmetry with the 4-tolyl group bis-ected by the plane. The configuration about both double bonds in the N-N=C-C=C chain is E; the chain has an all trans conformation...
April 1, 2017: Acta Crystallographica. Section E, Crystallographic Communications
https://www.readbyqxmd.com/read/28435260/development-of-gold-nanoparticles-coated-with-silica-containing-the-antibiofilm-drug-cinnamaldehyde-and-their-effects-on-pathogenic-bacteria
#3
Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee
Emerging resistance to antibiotics is a mounting worldwide health concern and increases the need for nonantibiotic strategies to combat infectious diseases caused by bacterial pathogens. In this study, the authors used the antibiofilm activity of the naturally occurring antimicrobial cinnamaldehyde (CNMA) conjugated to the surface of gold nanoparticles (GNPs) to deliver CNMA efficiently and eradicate biofilms of Gram-negative organisms (enterohemorrhagic Escherichia coli O157:H7, and Pseudomonas aeruginosa), Gram positive (methicillin-sensitive Staphylococcus aureus organisms, and methicillin-resistant Staphylococcus aureus) bacteria...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28429097/immunomodulatory-and-therapeutic-role-of-cinnamomum-verum-extracts-in-collagen-induced-arthritic-balb-c-mice
#4
Mirza Muhammad Fahd Qadir, Attya Bhatti, Muhammad Usman Ashraf, Mansur Abdullah Sandhu, Sidrah Anjum, Peter John
ETHNOPHARMACOLOGICAL RELEVANCE: Cinnamomum verum (CV), also known as 'Dalchini', is the dry bark of the Cinnamomum verum (L.) plant, and has been used as a traditional Pakistani medicine to alleviate pain and inflammation in patients suffering from arthritic rheumatism. It contains alkaloids, triterpenes, Cinnamaldehyde and other volatile oils. The aim of the present study was to investigate the underlying biological effect of ethyl alcohol (EtOH) and methyl alcohol (MeOH) extracts from CV on collagen type-II induced arthritic (CIA) mice...
April 20, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28400011/use-of-enhanced-nisin-derivatives-in-combination-with-food-grade-oils-or-citric-acid-to-control-cronobacter-sakazakii-and-escherichia-coli-o157-h7
#5
Alicia Campion, Ruth Morrissey, Des Field, Paul D Cotter, Colin Hill, R Paul Ross
Cronobacter sakazakii and Escherichia coli O157:H7 are well known food-borne pathogens that can cause severe disease. The identification of new alternatives to heating to control these pathogens in foods, while reducing the impact on organoleptic properties and nutritional value, is highly desirable. In this study, nisin and its bioengineered variants, nisin V and nisin S29A, are used alone, or in combination with plant essential oils (thymol, carvacrol and trans-cinnamaldehyde) or citric acid, with a view to controlling C...
August 2017: Food Microbiology
https://www.readbyqxmd.com/read/28398867/antimicrobial-efficacy-of-cinnamaldehyde-against-escherichia-coli-o157-h7-and-salmonella-enterica-in-carrot-juice-and-mixed-berry-juice-held-at-4%C3%A2-c-and-12%C3%A2-c
#6
David Manu, Aubrey F Mendonca, Aura Daraba, James S Dickson, Joseph Sebranek, Angela Shaw, Fei Wang, Shecoya White
The effectiveness of cinnamaldehyde for inactivating Salmonella enterica and Escherichia coli O157:H7 in carrot juice (CRJ) and mixed berry juice (MBJ) was investigated. Brain heart infusion broth (BHI), CRJ, and MBJ, with concentrations of added cinnamaldehyde ranging from 0.15 to 1.5 μL/mL, 0.25 to 2.0 μL/mL, and 0.25 to 1.5 μL/mL, respectively, were each inoculated with a 5-strain mixture of Salmonella enterica or Escherichia coli O157:H7 to give an initial viable count of 5.07 log10 colony-forming units/mL...
February 21, 2017: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/28392905/cinnamaldehyde-and-eugenol-change-the-expression-folds-of-akt1-and-dkc1-genes-and-decrease-the-telomere-length-of-human-adipose-derived-stem-cells-hascs-an-experimental-and-in-silico-study
#7
Abdorrahim Absalan, Seyed Alireza Mesbah-Namin, Taki Tiraihi, Taher Taheri
OBJECTIVES: To investigate the effect of cinnamaldehyde and eugenol on the telomere-dependent senescence of stem cells. In addition, to search the probable targets of mentioned phytochemicals between human telomere interacting proteins (TIPs) using in silico studies. MATERIALS AND METHODS: Human adipose derived stem cells (hASCs) were studied under treatments with 2.5 µM/ml cinnamaldehyde, 0.1 µg/ml eugenol, 0.01% DMSO or any additive. The expression of TERT, AKT1 and DKC1 genes and the telomere length were assessed over 48-hr treatment...
March 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28384605/simultaneous-quantification-of-11-active-constituents-in-shexiang-baoxin-pill-by-ultraperformance-convergence-chromatography-combined-with-tandem-mass-spectrometry
#8
Chao Lv, Liqing Chen, Peng Fu, Niao Yang, Qun Liu, Yongwei Xu, Qinglong Sun, Rui Li, Changsen Zhan, Weidong Zhang, Runhui Liu
On account of the complexity of chemical constituents of Shexiang Baoxin Pill (SBP), a famous traditional Chinese medicine (TCM) formula, a novel and effective UPC(2)-MS/MS method was developed to simultaneously determine the content of 11 active compounds of SBP with outstanding separation ability. Eleven components in SBP, including 2 ginsenosides, 2 bile acids, 3 bufadienolides and 4 volatiles were detected by electrospray ionization tandem mass spectrometry in positive and negative ion modes with multiple reaction monitor (MRM)...
March 31, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28355745/-cinnamaldehyde-attenuates-pressure-overload-induced-cardiac-fibrosis-via-inhibition-of-endothelial-mesenchymal-transition
#9
Y Xiao, Q Q Wu, X H Jiang, Q Z Tang
Objective: The aim of this study is to investigate the underlying mechanism of cinnamaldehyde attenuating pressure overload-induced cardiac fibrosis. Methods: The mice were randomly divided into control group, model group and treatment group by random number table and each group had 8 mice.Cardiac hypertrophy was induced by aortic banding. Heart vascular density was detected by immunohistochemical staining of CD31.The expression level of stromal cells marker α-smooth muscle actin (α-SMA) was detected by immunofluorescence staining in different groups...
March 21, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28353001/de-novo-biosynthesis-of-trans-cinnamic-acid-derivatives-in-saccharomyces-cerevisiae
#10
Manuela Gottardi, Jan Dines Knudsen, Lydie Prado, Mislav Oreb, Paola Branduardi, Eckhard Boles
The production of natural aroma compounds is an expanding field within the branch of white biotechnology. Three aromatic compounds of interest are cinnamaldehyde, the typical cinnamon aroma that has applications in agriculture and medical sciences, as well as cinnamyl alcohol and hydrocinnamyl alcohol, which have applications in the cosmetic industry. Current production methods, which rely on extraction from plant materials or chemical synthesis, are associated with drawbacks regarding scalability, production time, and environmental impact...
March 29, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28344372/radicals-and-molecular-products-from-the-gas-phase-pyrolysis-of-lignin-model-compounds-cinnamyl-alcohol
#11
Lavrent Khachatryan, Meng-Xia Xu, Ang-Jian Wu, Mikhail Pechagin, Rubik Asatryan
The experimental results on detection and identification of intermediate radicals and molecular products from gas-phase pyrolysis of cinnamyl alcohol (CnA), the simplest non-phenolic lignin model compound, over the temperature range of 400-800 °C are reported. The low temperature matrix isolation - electron paramagnetic resonance (LTMI-EPR) experiments along with the theoretical calculations, provided evidences on the generation of the intermediate carbon and oxygen centered as well as oxygen-linked, conjugated radicals...
September 2016: Journal of Analytical and Applied Pyrolysis
https://www.readbyqxmd.com/read/28342857/antinociceptive-and-anti-inflammatory-effects-of-the-methanolic-stem-bark-extract-of-antrocaryon-klaineanum-pierre-anacardiaceae-in-mice-and-rat
#12
Annie Laure Magne Fongang, Edwige Laure Nguemfo, Yolande Djouatsa Nangue, Calvin Bogning Zangueu, Yannick Fouokeng, Anatole Guy Blaise Azebaze, Eulogio José Llorent-Martínez, Maria Luisa Fernández-de Córdova, Alain Bertrand Dongmo, Wolfgang Vierling
ETHNOPHARMACOLOGICAL RELEVANCE: Antrocaryon klaineanum is used by traditional healers to treat many disorders including pain and inflammatory diseases. This study aimed to evaluate the analgesic and antiinflammatory activities of methanol extract of A. klaineanum in mice and rats. MATERIALS AND METHODS: Reverse phase high-performance liquid chromatography (RP-HPLC) was performed to establish the chromatographic fingerprint and to identify various chemical components of the plant extract...
May 5, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28342836/membrane-fatty-acid-composition-as-a-determinant-of-listeria-monocytogenes-sensitivity-to-trans-cinnamaldehyde
#13
Gil Rogiers, Biniam T Kebede, Ann Van Loey, Chris W Michiels
Trans-cinnamaldehyde, the major compound of cinnamon essential oil, is a potentially interesting natural antimicrobial food preservative. Although a number of studies have addressed its mode of action, the factors that determine bacterial sensitivity or tolerance to trans-cinnamaldehyde are poorly understood. We report the detailed characterization of a Listeria monocytogenes Scott A trans-cinnamaldehyde hypersensitive mutant defective in IlvE, which catalyzes the reversible transamination of branched-chain amino acids to the corresponding short-chain α-ketoacids...
March 23, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28339792/interference-of-age-and-supplementation-of-direct-fed-microbial-and-essential-oil-in-the-activity-of-digestive-enzymes-and-expression-of-genes-related-to-transport-and-digestion-of-carbohydrates-and-proteins-in-the-small-intestine-of-broilers
#14
M F Fernandez-Alarcon, N Trottier, J P Steibel, R Lunedo, D M B Campos, A M Santana, J M Pizauro, R L Furlan, L R Furlan
The objectives of this study were to describe alterations that age and dietary inclusion of direct-fed microbial (DFM) Bacillus subtilis (BS) and a specific essential oil (EO) blend (carvacrol, cinnamaldehyde, cineol, and pepper extract) causes in the activity of digestive enzymes (maltase: MALT; aminopeptidase-N: APN; intestinal alkaline phosphate: IAP) and expression patterns of genes related to transport (oligopeptide transporter gene: SLC15A1; Na+-dependent glucose and galactose transporter gene: SLC5A1; Na+-independent glucose, galactose, and fructose transporter gene: SLC2A2; ATPase, Na+/K+ transporting gene: ATP1A1) and digestion (aminopeptidase-N gene: ANPEP; maltase-glucoamylase gene: MGAM; Sucrase-isomaltase gene: SI) of carbohydrates and proteins in the small intestine of broilers...
February 23, 2017: Poultry Science
https://www.readbyqxmd.com/read/28337465/inflammatory-response-and-barrier-dysfunction-by-different-e-cigarette-flavoring-chemicals-identified-by-gas-chromatography-mass-spectrometry-in-e-liquids-and-e-vapors-on-human-lung-epithelial-cells-and-fibroblasts
#15
Janice Gerloff, Isaac K Sundar, Robert Freter, Emily R Sekera, Alan E Friedman, Risa Robinson, Todd Pagano, Irfan Rahman
Recent studies suggest that electronic cigarette (e-cig) flavors can be harmful to lung tissue by imposing oxidative stress and inflammatory responses. The potential inflammatory response by lung epithelial cells and fibroblasts exposed to e-cig flavoring chemicals in addition to other risk-anticipated flavor enhancers inhaled by e-cig users is not known. The goal of this study was to evaluate the release of the proinflammatory cytokine (interleukin-8 [IL-8]) and epithelial barrier function in response to different e-cig flavoring chemicals identified in various e-cig e-liquid flavorings and vapors by chemical characterization using gas chromatography-mass spectrometry analysis...
March 1, 2017: Applied in Vitro Toxicology
https://www.readbyqxmd.com/read/28334192/insecticidal-properties-of-essential-oils-and-some-of-their-constituents-on-the-turkestan-cockroach-blattodea-blattidae
#16
Sudip Gaire, Mary O'Connell, Francisco O Holguin, Anup Amatya, Scott Bundy, Alvaro Romero
The Turkestan cockroach, Blatta lateralis (Walker), has become the most important peridomestic species in urban areas of the Southwestern United States. The aim of this study was to evaluate the use of botanical compounds to control this urban pest. We tested the acute toxicity and repellency of six botanical constituents and three essential oils on Turkestan cockroach nymphs. Chemical composition of the essential oils was also determined. Topical and fumigant assays with nymphs showed that thymol was the most toxic essential oil constituent, with a LD50 of 0...
April 1, 2017: Journal of Economic Entomology
https://www.readbyqxmd.com/read/28322072/comparison-of-different-methods-for-extraction-of-cinnamomi-ramulus-yield-chemical-composition-and-in-vitro-antiviral-activities
#17
Jing Zhou, Xiurong Yuan, Ling Li, Tong Zhang, Bing Wang
Hydrodistillation (HD), supercritical fluid extraction (SFE) and reflux extraction (RE) were applied to obtain Cinnamomi ramulus extracts. The yields, chemical compositions and antiviral activities of the extracts were investigated. Extracts were analysed using gas chromatography-mass spectrometry and the antiviral activities were evaluated using cytopathic effect inhibition assay. HD, SFE and RE afforded 0.376, 1.227 and 5.914% yields, respectively. Cinnamaldehyde (CA), SFE and ethanol extracts exhibited antiviral activities against herpes simplex virus type 1...
March 21, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28317313/profiling-of-antioxidative-enzyme-expression-induced-by-various-food-components-using-targeted-proteome-analysis
#18
Sven Bartenbacher, Christiane Östreicher, Monika Pischetsrieder
SCOPE: A method was developed for targeted proteome analysis of the expression profile of a set of antioxidative enzymes in rat macrophages and applied to screen the antioxidative potential of several food components/foods. METHODS AND RESULTS: Expression profiles of heme oxygenase 1, peroxiredoxin 1, thioredoxin reductase 1, glutathione reductase, glutathione-S transferase P1, and superoxide dismutase 1 were analyzed by nanoLC-MS/MS in selected scheduled reaction monitoring (sSRM) mode monitoring two to three peptides per protein and three transitions per peptide...
March 20, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28288793/a-novel-zebrafish-based-model-of-nociception
#19
J Christopher Taylor, L Savannah Dewberry, Stacie K Totsch, Lindsey R Yessick, Jennifer J DeBerry, Stephen A Watts, Robert E Sorge
Chronic pain affects the lives of millions yearly, but few new treatments are available. Due to decreasing budgets and increasing costs of preclinical research, alternatives are sought with high translatability and low cost. Here we demonstrate the utility of a zebrafish-based model of nociception to serve as a novel screening tool for analgesic drugs. Zebrafish swimming behavior was measured following administration of various algogens including histamine, cinnamaldehyde, mustard oil, acetic acid and complete Freund's adjuvant...
March 10, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28278675/cytotoxicity-of-flavonoids-and-isoflavonoids-from-crotalaria-bracteata
#20
Sukanda Sudanich, Suppachai Tiyaworanant, Chavi Yenjai
A new flavonoid, crotakanda (1), and seven known compounds including a flavonoid, four isoflavonoids, a pterocarpan and a cinnamaldehyde were isolated from the stems and roots of Crotalaria bracteata. Their structures were elucidated by a combination of spectroscopic methods. Compound 2 showed cytotoxicity against MCF-7 with an IC50 value of 79.90 μM whereas 2 and 4 exhibited cytotoxicity against the NCI-H187 cell line with IC50 values of 71.57 and 95.47 μM, respectively.
February 13, 2017: Natural Product Research
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