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Cinnamaldehyde

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https://www.readbyqxmd.com/read/28719892/cinnamaldehyde-ameliorates-diet-induced-obesity-in-mice-by-inducing-browning-of-white-adipose-tissue
#1
Jiacheng Zuo, Dandan Zhao, Na Yu, Xin Fang, Qianqian Mu, Yue Ma, Fangfang Mo, Rui Wu, Rufeng Ma, Lili Wang, Ruyuan Zhu, Haixia Liu, Dongwei Zhang, Sihua Gao
BACKGROUND/AIMS: Obesity has become a major health concern with few effective medications. Cinnamaldehyde (CA) has been reported to exhibit anti-diabetic and anti-inflammatory properties. However, whether CA shows anti-obesity activity remains unknown. Therefore, the present study aimed to investigate the potential anti-obesity effects of CA on mice fed a high-fat diet (HFD) and to explore the possible mechanisms involved. METHODS: Male C57BL/6J mice fed an HFD for 12 weeks were supplemented with CA (40 mg/kg/day) via gavage for an additional 8 weeks...
July 18, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28708465/synthesis-characterization-redox-behavior-dna-and-protein-binding-and-antibacterial-activity-studies-of-ruthenium-ii-complexes-of-bidentate-schiff-bases
#2
Hena Paul, Buddhadeb Sen, Tapan Kumar Mondal, Pabitra Chattopadhyay
Two new ruthenium(II) complexes of Schiff base ligands (L) derived from cinnamaldehyde and ethylenediamine formulated as [Ru(L)(bpy)2](ClO4)2, where L(1) = N,N'-bis(4-nitrocinnamald-ehyde)ethylenediamine and L(2) = N,N'-bis(2-nitrocinnamaldehyde)-ethylenediamine for complex 1 and 2, respectively, were isolated in pure form. The complexes were characterized by physicochemical and spectroscopic methods. The electrochemical behavior of the complexes showed the Ru(III)/Ru(II) couple at different potentials with quasi-reversible voltammograms...
July 14, 2017: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/28695467/new-route-for-the-synthesis-of-new-cyanoimino-and-cyanoaminopyrimidines
#3
Amer Anwar Amer, Amr Hassan Moustafa
A novel series of 4-aryl-2-cyanoimino-3,4-dihydro-1H-pyrimidines (aryl-CIDHPMs) was synthesized using a new method via the one-pot three-component reaction of cyanoguanidine with malononitrile and aromatic aldehydes using sodium methoxide as catalyst. These new aryl-CIDHPMs were also prepared by a classical route via reaction of cyanoguanidine with the corresponding arylidenemalononitriles under our conditions. In the same manner, the reaction of cyanoguanidine with cyclohexylidenemalononitrile and/or isatinylidenemalononitrile afforded new spiro-pyrimidines 9 and 10, respectively...
July 10, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28688915/targeted-proteome-analysis-with-isotope-coded-protein-labels-for-monitoring-the-influence-of-dietary-phytochemicals-on-the-expression-of-cytoprotective-proteins-in-primary-human-colon-cells
#4
Christiane Östreicher, Sven Bartenbacher, Monika Pischetsrieder
Cytoprotective effects by upregulating cellular expression levels of antioxidant proteins are attributed to a significant number of food ingredients. Evaluation of those cytoprotective effects and identification of the most active components requires reliable and comprehensive proteomic strategies. Thus, promising potential bioactive ingredients could be determined for the prevention of various diseases, including colon cancer formation. We established a multiplexed nanoLC-MS/MS targeted proteomic method, operated in scheduled selected reaction monitoring mode (sSRM), to record modulation of the expression levels of six major antioxidant proteins induced by dietary phytochemicals...
July 6, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28678344/prebiotic-potential-and-chemical-composition-of-seven-culinary-spice-extracts
#5
Qing-Yi Lu, Paula H Summanen, Ru-Po Lee, Jianjun Huang, Susanne M Henning, David Heber, Sydney M Finegold, Zhaoping Li
The objective of this study was to investigate prebiotic potential, chemical composition, and antioxidant capacity of spice extracts. Seven culinary spices including black pepper, cayenne pepper, cinnamon, ginger, Mediterranean oregano, rosemary, and turmeric were extracted with boiling water. Major chemical constituents were characterized by RP-HPLC-DAD method and antioxidant capacity was determined by measuring colorimetrically the extent to scavenge ABTS radical cations. Effects of spice extracts on the viability of 88 anaerobic and facultative isolates from intestinal microbiota were determined by using Brucella agar plates containing serial dilutions of extracts...
July 5, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28671709/transient-receptor-potential-a1-trpa1-agonists-inhibit-contractions-of-the-isolated-human-ureter
#6
Philipp Weinhold, Martin Hennenberg, Frank Strittmatter, Christian G Stief, Christian Gratzke, Petter Hedlund
AIMS: Mechanoafferent and peristaltic mechanisms of the human ureter involve transient receptor potential V1 (TRPV1)- and purinoceptor-mediated functions. Hydrogen sulphide, an endogenous TRPA1 ligand, is linked to inhibitory neurotransmission of the pig ureter. No information is available on TRPA1 activity in the human ureter. We therefore examined the distribution and function of TRPA1 in the human ureter. METHODS: Expression of TRPA1 in human ureter tissue was studied by Western blot and immunofluorescence...
July 3, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28669386/dietary-cinnamaldehyde-enhances-acquisition-of-specific-antibodies-following-helminth-infection-in-pigs
#7
Andrew R Williams, Tina V A Hansen, Lukasz Krych, Hajar Fauzan Bin Ahmad, Dennis S Nielsen, Kerstin Skovgaard, Stig M Thamsborg
Dietary phytonutrients such as cinnamaldehyde (CA) may contribute to immune function during pathogen infections, and CA has been reported to have positive effects on gut health when used as feed additive for livestock. Here, we investigated whether CA could enhance antibody production and specific immune responses during infection with an enteric pathogen. We examined the effect of dietary CA on plasma antibody levels in parasite-naïve pigs, and subsequently acquisition of humoral immune responses during infection with the parasitic nematode Ascaris suum...
July 2017: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/28633539/a-survey-on-chemical-constituents-and-indications-of-aromatic-waters-soft-drinks-hydrosols-used-in-persian-nutrition-culture-and-folk-medicine-for-neurological-disorders-and-mental-health
#8
Azadeh Hamedi, Ardalan Pasdaran, Zahra Zebarjad, Mahmoodreza Moein
In Persian nutrition culture, drinking aromatic waters (hydrosols, distillate) has a long history as functional beverages or therapeutic remedies. The co-distilled water with essential oils, which contains partial amounts of more water-soluble volatile compounds are diluted and used as beverages. Since the solubility of volatile components is different in water, the overall composition, and thus the biological activities of aromatic waters seem to be different from the essential oils they were co-distilled with...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/28627304/the-effects-of-selected-phytochemicals-on-biofilm-formed-by-five-methicillin-resistant-staphylococcus-aureus
#9
Barbara Kot, Kamila Wierzchowska, Agata Grużewska, Dzmitry Lohinau
The aim of this study was to evaluate the ability of 0.1% thyme oil (TO), trans-cinnamaldehyde (TC), ferulic acid (FA), p-coumaric acid (p-CA), caffeic acid (CA), lavender essential oil (LO), geranium essential oil (GO) and tee tree oil (TTO) to control biofilms formed by methicillin-resistant Staphylococcus aureus (MRSA) strains. Depending on the strains, TO reduced 59.7-85% of biofilm mass, while TC 52.9-82.4% after 48 h of treatment. Reduction of metabolic activity of biofilms in ranges 79.3-86% and 85...
June 18, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28620947/effect-of-applying-cinnamaldehyde-incorporated-in-wax-on-green-mold-decay-in-citrus-fruits
#10
Xiaofang Duan, Qiuli OuYang, Nengguo Tao
BACKGROUND: Green mold caused by Penicillium digitatum is the most damaging postharvest diseases of citrus fruit. Cinnamaldehyde (CA) is a food additive that has potential use in controlling postharvest disease of fruits and vegetables. In this study, the effectiveness of wax with CA (WCA) in controlling Ponkan (Citrus reticulata Blanco) green mold was investigated. RESULTS: The mycelial growth of P. digitatum was inhibited by CA in a dose-dependent manner. The minimum inhibitory concentration and minimum fungicidal concentration (MFC) were both 0...
June 16, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28605202/supramolecular-construction-of-an-aldehyde-cyclobutane-via-the-solid-state-combining-reversible-imine-formation-and-metal-organic-self-assembly
#11
Shalisa M Oburn, Dale C Swenson, S V Santhana Mariappan, Leonard R MacGillivray
A combination of metal-organic self-assembly and reversible imine formation is used to achieve an organic synthesis via the solid state. Imine bond formation is employed to install a pyridyl to the alkene trans-cinnamaldehyde while Ag(I) ions are used in a second step to assemble the pyridyl-functionalized alkene into a geometry in the solid state for an intermolecular [2 + 2] photodimerization. The alkene undergoes the cycloaddition reaction via a 1D coordination polymer to generate a pyridyl-functionalized cyclobutane stereoselectively and in quantitative yield...
June 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28600870/selective-catalytic-performances-of-noble-metal-nanoparticle-mof-composites-the-concomitant-effect-of-aperture-size-and-structural-flexibility-of-mof-matrices
#12
Luning Chen, Wenwen Zhan, Huihuang Fang, Zhenmin Cao, Chaofan Yuan, Zhaoxiong Xie, Qin Kuang, Lansun Zheng
Noble metal nanoparticles embedded in metal organic frameworks (MOFs) are new composite catalysts with enhanced or novel properties compared to the pristine counterparts. In the past years, to determine the role of MOFs during catalytic process, most of studies focus on the confinement effect of MOFs, but ignore the structural flexibility of MOFs. In this paper, we use two composite catalysts, Pt@ZIF-8 [Zn(mIM)2, mIM = 2-methyl imidazole] with flexible structure and Pt@ZIF-71 [Zn(DClIM)2, DClIM = 4,5-dichloroimidazole] with rigid structure, and hydrogenation of cinnamaldehyde as model reaction, to show the confinement effect and the structure flexibility of MOF matrices on the catalytic performance of composite catalysts...
June 10, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28585246/confining-the-nucleation-of-pt-to-in-situ-form-pt-enriched-cage-ceo2-core-shell-nanostructure-as-excellent-catalysts-for-hydrogenation-reactions
#13
Songyan Song, Xianchun Liu, Junqi Li, Jing Pan, Fan Wang, Yan Xing, Xiao Wang, Xiaogang Liu, Hongjie Zhang
Ultrathin (Pt-enriched cage)@CeO2 core@shell nanostructures are successfully fabricated via a facile hard-template method. It is found that the usage of Pd@Ag@CeO2 bi-metallic core@shell nanostructure as the hard template plays an important role in avoiding the independent nucleation of Pt metal during the galvanic replacement process between K2 PtCl4 and Ag components. This unique core@shell samples show extraordinary activity and selectivity for the cinnamaldehyde hydrogenation reaction. It can achieve over 95% conversion with 87% selectivity of hydrocinnamaldehyde in 5 h under 1 atm H2 pressure...
June 6, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28560053/volatiles-profiling-in-ceratonia-siliqua-carob-bean-from-egypt-and-in-response-to-roasting-as-analyzed-via-solid-phase-microextraction-coupled-to-chemometrics
#14
Mohamed A Farag, Dina M El-Kersh
Ceratonia siliqua is a legume tree of considerable commercial importance for the flavor and sweets industry cultivated mostly for its pods nutritive value and or several health benefits. Despite extensive studies on C. siliqua pod non-volatile metabolites, much less is known regarding volatiles composition which contributes to the flavor of its many food products. To gain insight into C. siliqua aroma, 31 volatile constituents from unroasted and roasted pods were profiled using headspace solid-phase micro extraction (HD-SPME) analyzed via quadruple mass spectrometer followed by multivariate data analyses...
July 2017: Journal of Advanced Research
https://www.readbyqxmd.com/read/28559210/cinnamaldehyde-in-diabetes-a-review-of-pharmacology-pharmacokinetics-and-safety
#15
REVIEW
Ruyuan Zhu, Haixia Liu, Chenyue Liu, Lili Wang, Rufeng Ma, Beibei Chen, Lin Li, Jianzhao Niu, Min Fu, Dongwei Zhang, Sihua Gao
Cinnamaldehyde, one of the active components derived from Cinnamon, has been used as a natural flavorant and fragrance agent in kitchen and industry. Emerging studies have been performed over the past decades to evaluate its beneficial role in management of diabetes and its complications. This review highlights recent advances of cinnamaldehyde in its glucolipid lowering effects, its pharmacokinetics, and its safety by consulting the Pubmed, China Knowledge Resource Integrated, China Science and Technology Journal, National Science and Technology Library, Wanfang Data, and the Web of Science Databases...
May 27, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28556537/insecticidal-activities-of-their-components-derived-from-the-essential-oils-of-cinnamomum-sp-barks-and-against-ricania-sp-homoptera-ricaniidae-a-newly-recorded-pest
#16
Ye-Jin Jeon, Sang-Guei Lee, Young-Cheol Yang, Hoi Seon Lee
BACKGROUND: Insecticidal activities of Cinnamomum cassia and C. zeylanicum oils and their components are not known against Ricania sp. Insecticidal activities of major components derived from C. cassia and C. zeylanicum oils were examined in spray and leaf dipping bioassays against Ricania sp. nymphs and adults. RESULTS: LC50 value of C. cassia and C. zeylanicum oils was 37.66 and 72.62 mg/L, respectively, in the leaf dipping bioassays against Ricania sp. nymphs, and 77...
May 27, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28534638/diastereoselective-3-2-vs-4-2-cycloadditions-of-nitroprolinates-with-%C3%AE-%C3%AE-unsaturated-aldehydes-and-electrophilic-alkenes-an-example-of-total-periselectivity
#17
Verónica Selva, Olatz Larrañaga, Luis M Castelló, Carmen Nájera, José M Sansano, Abel de Cózar
Diastereoselective multicomponent reactions of enantioenriched 4-nitroprolinates, obtained by enantiocatalyzed 1,3-dipolar cycloaddition (1,3-DC) of imino esters and nitroalkenes, with α,β-unsaturated aldehydes and electrophilic alkenes proceed with total periselectivity depending on the structure of the aldehyde employed. This process evolves through a [3 + 2] 1,3-DC when cinnamaldehyde is used in the presence of an azomethine ylide, giving the corresponding highly substituted pyrrolizidines with endo selectivity...
June 7, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28526768/direct-comparison-of-the-enzymatic-characteristics-and-superoxide-production-of-the-four-aldehyde-oxidase-enzymes-present-in-mouse
#18
Gokhan Kucukgoze, Mineko Terao, Enrico Garattini, Silke Leimkuhler
Aldehyde oxidases (AOXs) are molybdoflavoenzymes with an important role in the metabolism and detoxification of heterocyclic compounds and aliphatic as well as aromatic aldehydes. The enzymes use oxygen as the terminal electron acceptor and produce reduced oxygen species during turnover. Four different enzymes, mAOX1, mAOX3, mAOX4 and mAOX2, which are the products of distinct genes, are present in the mouse. A direct and simultaneous comparison of the enzymatic properties and characteristics of the four enzymes has never been performed...
May 19, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28525761/impact-of-bioactive-packaging-systems-based-on-evoh-films-and-essential-oils-in-the-control-of-aflatoxigenic-fungi-and-aflatoxin-production-in-maize
#19
Eva M Mateo, José V Gómez, Irene Domínguez, Jose V Gimeno-Adelantado, Rufino Mateo-Castro, Rafael Gavara, Misericordia Jiménez
Aspergillus flavus and A. parasiticus are the most common fungal species associated with aflatoxin (AF) contamination of cereals, especially maize, and other agricultural commodities. AFB1, the most frequent and toxic metabolite, is a powerful hepatotoxic, teratogenic and mutagenic compound. Effective strategies to control these fungal species and AFs in food and feed are required. Active packaging film containing essential oils (EO) is one of the most innovative food packaging concepts. In this study, ethylene-vinyl alcohol (EVOH) copolymer films incorporating EO from Origanum vulgare (ORE), Cinnamomum zeylanicum (CIN) or their major active constituents, carvacrol (CAR) and cinnamaldehyde (CINHO), respectively, were developed and assayed to control growth of A...
May 11, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28521511/effects-of-adaptation-to-carvacrol-on-staphylococcus-aureus-in-the-planktonic-and-biofilm-phases
#20
Antonia Nostro, Andreana Marino, Giovanna Ginestra, Luigina Cellini, Mara Di Giulio, Giuseppe Bisignano
The effect of exposure to sub-minimum inhibitory concentrations of carvacrol, for either 3-10 days, on direct (carvacrol) or cross-protection (cinnamaldehyde, eugenol, antibiotics) and the influence on planktonic and biofilm growth of four Staphylococcus aureus strains were reported. The sequential exposure to carvacrol resulted in a direct protection that was more evident in two of the four strains after 10 days. No significant cross-protection against cinnamaldehyde, eugenol and antibiotics was detected...
May 18, 2017: Biofouling
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