keyword
MENU ▼
Read by QxMD icon Read
search

Obestatin

keyword
https://www.readbyqxmd.com/read/27901469/obestatin-improves-hepatic-injury-induced-by-ischemia-reperfusion-in-rats-role-of-nitric-oxide
#1
Ola A El-Gohary
Hepatic ischemia/reperfusion (I/R) injury is a common clinical problem. The present study was conducted to evaluate the protective effect of obestatin against I/R-induced liver injury. Rats were divided into three groups (n = 10): control sham-operated group, I/R group and obestatin treatment group. Rats of I/R group and obestatin treatment group underwent partial hepatic ischemia for 60 min followed by 90 min reperfusion. At the beginning of the 90-min reperfusion period, rats of obestatin treatment group were injected with obestatin (100 μg/kg) intravenously...
November 30, 2016: General Physiology and Biophysics
https://www.readbyqxmd.com/read/27900560/serum-leptin-obestatin-and-ghrelin-levels-and-gastric-emptying-rates-of-liquid-and-solid-meals-in-non-obese-rats-with-roux-en-y-bypass-surgery-or-prosthesis-placement-implications-for-the-role-of-vagal-afferents
#2
Yunus Yavuz, Zarife Nigar Özdemir Kumral, Gülsün Memi, Özge Dağdeviren Çevik, Cumhur Yeğen, Berrak Ç Yeğen
BACKGROUND: The present study aimed to investigate the effects of Roux-en-Y gastric bypass (RYGB) and prosthesis placement on gastric emptying rate in conjunction with serum ghrelin-obestatin-leptin responses in non-obese rats with intact or denervated afferent innervation. METHODS: Under anesthesia, male Sprague-Dawley rats underwent either sham operation, RYGB, prosthesis, and/or Gregory cannula placement. Three weeks later, liquid or solid gastric emptying tests were performed and serum ghrelin, leptin and obestatin levels were measured...
November 29, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27825986/intracerebroventricular-injection-of-ghrelin-decreases-wheel-running-activity-in-rats
#3
Yumiko Miyatake, Tetsuya Shiuchi, Kazuaki Mawatari, Satomi Toda, Yasuko Taniguchi, Akari Futami, Fukiko Sato, Masashi Kuroda, Mayu Sebe, Rie Tsutsumi, Nagakatsu Harada, Yasuhiko Minokoshi, Tadahiro Kitamura, Koro Gotoh, Masaki Ueno, Yutaka Nakaya, Hiroshi Sakaue
There is an increasing interest in elucidating the molecular mechanisms by which voluntary exercise is regulated. In this study, we examined how the central nervous system regulates exercise. We used SPORTS rats, which were established in our laboratory as a highly voluntary murine exercise model. SPORTS rats showed lower levels of serum ghrelin compared with those of the parental line of Wistar rats. Intracerebroventricular and intraperitoneal injection of ghrelin decreased wheel-running activity in SPORTS rats...
November 5, 2016: Peptides
https://www.readbyqxmd.com/read/27782745/obestatin-modulates-ghrelin-s-effects-on-the-basal-and-stimulated-testosterone-secretion-by-the-testis-of-rat-an-in-vitro-study
#4
T Afsar, S Jahan, S Razak, A Almajwal, M Abulmeaty, H Wazir, A Majeed
The functional antagonism between obestatin and ghrelin in testis is under investigated. We investigated the ability of obestatin to counteract the inhibitory effect of ghrelin on basal and stimulated testosterone (T) secretion in vitro. Testicular strips from adult rats were incubated with 10 ng/ml and 100 ng/ml of obestatin alone, ghrelin alone and obestatin + ghrelin. Obestatin modulation of stimulated T secretion was evaluated by incubation of testicular samples with 10 ng/ml and 100 ng/ml obestatin, ghrelin and obestatin+ ghrelin in the absence and presence of 10 IU of human chorionic gonadotrophin (hCG)...
October 26, 2016: Physiological Research
https://www.readbyqxmd.com/read/27775083/bacterial-mimetics-of-endocrine-secretory-granules-as-immobilized-in-vivo-depots-for-functional-protein-drugs
#5
María Virtudes Céspedes, Yolanda Fernández, Ugutz Unzueta, Rosa Mendoza, Joaquin Seras-Franzoso, Alejando Sánchez-Chardi, Patricia Álamo, Verónica Toledo-Rubio, Neus Ferrer-Miralles, Esther Vázquez, Simó Schwartz, Ibane Abasolo, José Luis Corchero, Ramon Mangues, Antonio Villaverde
In the human endocrine system many protein hormones including urotensin, glucagon, obestatin, bombesin and secretin, among others, are supplied from amyloidal secretory granules. These granules form part of the so called functional amyloids, which within the whole aggregome appear to be more abundant than formerly believed. Bacterial inclusion bodies (IBs) are non-toxic, nanostructured functional amyloids whose biological fabrication can be tailored to render materials with defined biophysical properties. Since under physiological conditions they steadily release their building block protein in a soluble and functional form, IBs are considered as mimetics of endocrine secretory granules...
October 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27750262/the-obestatin-ghrelin-ratio-and-ghrelin-genetics-in-adult-celiac-patients-before-and-after-a-gluten-free-diet-in-irritable-bowel-syndrome-patients-and-healthy-individuals
#6
Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
BACKGROUND: Ghrelin levels and obestatin/ghrelin ratio have been proposed as activity markers in ulcerative colitis, but no data are available in celiac disease (CD) and irritable bowel syndrome (IBS). Our aims were as follows: (a) to assess obestatin and ghrelin concentrations in adult active CD patients, diarrhea-predominant IBS (IBS-d), and healthy controls (HC) in relation to intestinal permeability; (b) to evaluate the ghrelin-obestatin profile in CD patients after a 1-year gluten-free diet (GFD); and (c) to establish the impact of ghrelin genetics...
October 12, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27693419/hypothalamic-regulation-of-body-growth-and-appetite-by-ghrelin-derived-peptides-during-balanced-nutrition-or-undernutrition
#7
Rim Hassouna, Alexandra Labarthe, Virginie Tolle
Among the gastrointestinal hormones that regulate food intake and energy homeostasis, ghrelin plays a unique role as the first one identified to increases appetite and stimulate GH secretion. This review highlights the latest mechanism by which ghrelin modulates body growth, appetite and energy metabolism by exploring pharmacological actions of the hormone and consequences of genetic or pharmacological blockade of the ghrelin/GHS-R (Growth Hormone Secretagogue Receptor) system on physiological responses in specific nutritional situations...
September 28, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27682709/endoglin-and-obestatin-levels-cardiometabolic-risk-factors-and-subclinical-atherosclerosis-in-children-aged-10-18-years
#8
Nurullah Çelik, Peyami Cinaz, Aysun Bideci, Betül Derinkuyu, Hamdi Cihan Emeksiz, Esra Döğer, Çağrı Damar, Özge Yüce, Orhun Çamurdan
BACKGROUND: The aim of this study was to investigate the early signs of atherosclerosis and to evaluate serum endoglin and obestatin levels as predictors of subclinical atherosclerosis in obese children. METHODS: A total of 95 children (60 obese and 35 controls) aged 10-18 years were included in the study. Their endoglin and obestatin levels and biochemical parameters were measured. The carotid intima media thickness (cIMT) and brachial artery flow-mediated dilatation (FMD) responses were evaluated...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/27530317/ghrelin-gene-products-rescue-cultured-adult-rat-hippocampal-neural-stem-cells-from-high-glucose-insult
#9
Sehee Kim, Chanyang Kim, Seungjoon Park
Adult hippocampal neurogenesis is decreased in type 2 diabetes, and this impairment appears to be important in cognitive dysfunction. Previous studies suggest that ghrelin gene products (acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin (OB)) promote neurogenesis. Therefore, we hypothesize that ghrelin gene products may reduce the harmful effects of high glucose (HG) on hippocampal neural stem cells (NSCs). The aim of this study was to investigate the role of these peptides on the survival of cultured hippocampal NSCs exposed to HG insult...
October 2016: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/27508828/-op-7b-09-chemerin-and-blood-pressure-and-metabolic-syndrome-in-postmenopausal-women
#10
A Olszanecka, K Kawecka-Jaszcz, D Czarnecka
OBJECTIVE: Chemerin is recently identified adipose hormone, which plays a role in adipogenesis, energy metabolism and inflammation. Increased levels of chemerin have been linked to obesity and development of diabetes mellitus. During the transition from premenopause to postmenopause, many women experience weight gain and central fat deposition, hence we hypothesized that circulating level of chemerin can play a role in the pathogenesis of hypertension and cardiometabolic risk in postmenopausal females...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27471436/treatment-of-lean-and-diet-induced-obesity-dio-mice-with-a-novel-stable-obestatin-analogue-alters-plasma-metabolite-levels-as-detected-by-untargeted-lc-ms-metabolomics
#11
Elaine Cowan, Praveen Kumar, Kerry J Burch, David J Grieve, Brian D Green, Stewart F Graham
INTRODUCTION: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. OBJECTIVES: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys(10), Cys(13))) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obesity (DIO) C57BL6/J mice. METHODS: Untargeted LC-HRMS metabolomics experiments were carried out in ESI + mode with plasma extracts from both groups of animals...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27449711/the-role-of-obestatin-in-roux-en-y-gastric-bypass-surgery-in-the-obese-type-2-diabetes-zucker-rat
#12
Xianhui Xu, Jianli Wang, Ling Li, Chunbin Wang, Weihua Li, Qin Zhang, Linghui Yang
AIMS: Roux-en-Y gastric bypass (RYGB) is a novel therapy for diabetes and the exact mechanisms of this procedure remain unclear. Obestatin is an important gut hormone. We aimed to explore the role of obestatin in the therapeutic mechanism of RYGB. METHODS: Twenty obese Zucker rats and twenty Wistar rats were randomly assigned to two groups: RYGB and sham surgery. We evaluated plasma obestatin and insulin levels pre- and post-RYGB. Additionally, obestatin expression levels in the gastrointestinal tract were assessed using immunohistochemical staining...
September 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27439698/c-fos-induction-by-gut-hormones-and-extracellular-atp-in-osteoblastic-like-cell-lines
#13
Elda Leonor Pacheco-Pantoja, Jane P Dillon, Peter J M Wilson, William D Fraser, James A Gallagher
It is widely accepted that the c-Fos gene has a role in proliferation and differentiation of bone cells. ATP-induced c-Fos activation is relevant to bone homeostasis, because nucleotides that are present in the environment of bone cells can contribute to autocrine/paracrine signalling. Gut hormones have previously been shown to have an effect on bone metabolism. In this study, we used the osteoblastic Saos-2 cell line transfected with a c-Fos-driven reporter stimulated with five gut hormones: glucose inhibitory peptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), ghrelin and obestatin, in the presence or absence of ATP...
July 20, 2016: Purinergic Signalling
https://www.readbyqxmd.com/read/27383154/changes-in-behavior-and-blood-corticosterone-level-in-male-and-female-rats-after-single-administration-of-obestatin-fragment-1-4
#14
E S Motorykina, E A Khirazova, M V Maslova, A V Graf, A S Maklakova, A A Bayzhumanov, O D Kurko, L A Andreeva, N A Sokolova, N F Myasoedov, A A Kamenskii
Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female rats was revealed. Obestatin fragment 1-4 had no effect on corticosterone level 1 week after single administration in both females and male rats.
June 2016: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27348010/an-evaluation-of-acylated-ghrelin-and-obestatin-levels-in-childhood-obesity-and-their-association-with-insulin-resistance-metabolic-syndrome-and-oxidative-stress
#15
Maryam Razzaghy-Azar, Mitra Nourbakhsh, Abdolreza Pourmoteabed, Mona Nourbakhsh, Davod Ilbeigi, Mohsen Khosravi
BACKGROUND: Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake. The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters...
2016: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27261628/obestatin-attenuated-doxorubicin-induced-cardiomyopathy-via-enhancing-long-noncoding-mhrt-rna-expression
#16
Hong-Qi Li, Yuan-Bo Wu, Chang-Sen Yin, Li Chen, Qi Zhang, Li-Qun Hu
OBJECTIVE: The emergence of side-effect of doxorubicin in cardiomyopathy and heart failure has led to the search for diverse strategies to prevent its cytotoxic effects. This study was to determine the role of obestatin on doxorubicin-induced cardiomyocytes apoptosis and possible underlying mechanism. METHODS: Sprague Dawley rats were divided into 3 groups and received treatment for a total of 6 weeks: group1, untreated normal rats; group2, Doxorubicin-induced heart cardiomyopathy (DC) rats; and group3, obestatin treated HC rats...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27249612/the-impact-of-laparoscopic-sleeve-gastrectomy-on-plasma-obestatin-and-ghrelin-levels
#17
U Dogan, H Y Ellidag, A Aslaner, T Cakir, M T Oruc, U Koc, B Mayir, I Gomceli, N Bulbuller, N Yılmaz
OBJECTIVE: To investigate the effect of laparoscopic sleeve gastrectomy (LSG) on the levels of obestatin and ghrelin hormones and body mass index (BMI) in morbidly obese patients. PATIENTS AND METHODS: The study included 30 morbidly obese patients who had LSG. Five cc blood samples were taken from the patients preoperatively and at postoperative months 3 and 6. After serum extraction, the levels of obestatin and ghrelin hormones and the levels of fasting insulin and glucose were studied using the enzyme-linked immunosorbent assay (ELISA) method...
May 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27235705/annals-express-concentrations-of-prealbumin-and-some-appetite-controlling-hormones-in-women-with-hyperemesis-gravidarium
#18
Gulfer Ozturk, A Seval Ozgu-Erdinc, Fatma Ucar, Zeynep Ginis, Gonul Erden, Nuri Danisman
BACKGROUND: Hyperemesis gravidarum (HG), which affects 0.3-2.3% of pregnancies, is defined as excessive vomiting during pregnancy and usually starts in week 4 or 5 of gestation. Symptoms include weight loss, dehydration, ketonaemia, ketonuria, fasting acidosis, alkalosis due to hydrochloric acid loss and hypokalaemia and its exact cause is unknown. The present study was undertaken to investigate the relationship between prealbumin, ghrelin, nesfatin-1 and obestatin concentrations in pregnancies associated with HG METHODS: : A total of 40 pregnant women with HG and 38 pregnant women without HG as controls, were included in this study...
May 27, 2016: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/27127509/maternal-high-fat-diet-during-pregnancy-and-lactation-influences-obestatin-and-ghrelin-concentrations-in-milk-and-plasma-of-wistar-rat-dams-and-their-offspring
#19
Monika Słupecka, Katarzyna Romanowicz, Jarosław Woliński
The study aims to establish the effect of a maternal high-fat diet on obestatin concentration, total ghrelin, and ghrelin/obestatin ratio during pregnancy and lactation of Wistar rats and their offspring in the first 21 days of life. On the mating day, females were randomly allocated and fed either a high-fat diet (30% of fat; HF) or breeding diet (5% fat; BD) till the 21st day of lactation. Hormones were analyzed in the blood plasma and milk of rat dams as well as in the blood plasma of their offspring. HF resulted in a significant decrease in obestatin level on the 14th day of lactation and elevation on the 21st day...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27111465/obestatin-as-a-key-regulator-of-metabolism-and-cardiovascular-function-with-emerging-therapeutic-potential-for-diabetes
#20
REVIEW
Elaine Cowan, Kerry J Burch, Brian D Green, David J Grieve
Obestatin is a 23-amino acid C-terminally amidated gastrointestinal peptide derived from preproghrelin and which forms an α helix. Although obestatin has a short biological half-life and is rapidly degraded, it is proposed to exert wide-ranging pathophysiological actions. Whilst the precise nature of many of its effects is unclear, accumulating evidence supports positive actions on both metabolism and cardiovascular function. For example, obestatin has been reported to inhibit food and water intake, body weight gain and gastrointestinal motility and also to mediate promotion of cell survival and prevention of apoptosis...
July 2016: British Journal of Pharmacology
keyword
keyword
71321
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"