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Francesco Russo, Guglielmina Chimienti, Michele Linsalata, Caterina Clemente, Antonella Orlando, Giuseppe Riezzo
BACKGROUND: Ghrelin levels and obestatin/ghrelin ratio have been proposed as activity markers in ulcerative colitis, but no data are available in celiac disease (CD) and irritable bowel syndrome (IBS). Our aims were as follows: (a) to assess obestatin and ghrelin concentrations in adult active CD patients, diarrhea-predominant IBS (IBS-d), and healthy controls (HC) in relation to intestinal permeability; (b) to evaluate the ghrelin-obestatin profile in CD patients after a 1-year gluten-free diet (GFD); and (c) to establish the impact of ghrelin genetics...
October 12, 2016: European Journal of Gastroenterology & Hepatology
Rim Hassouna, Alexandra Labarthe, Virginie Tolle
Among the gastrointestinal hormones that regulate food intake and energy homeostasis, ghrelin plays a unique role as the first one identified to increases appetite and stimulate GH secretion. This review highlights the latest mechanism by which ghrelin modulates body growth, appetite and energy metabolism by exploring pharmacological actions of the hormone and consequences of genetic or pharmacological blockade of the ghrelin/GHS-R (Growth Hormone Secretagogue Receptor) system on physiological responses in specific nutritional situations...
September 28, 2016: Molecular and Cellular Endocrinology
Nurullah Çelik, Peyami Cinaz, Aysun Bideci, Betül Derinkuyu, Hamdi Cihan Emeksiz, Esra Döğer, Çağrı Damar, Özge Yüce, Orhun Çamurdan
BACKGROUND: The aim of this study was to investigate the early signs of atherosclerosis and to evaluate serum endoglin and obestatin levels as predictors of subclinical atherosclerosis in obese children. METHODS: A total of 95 children (60 obese and 35 controls) aged 10-18 years were included in the study. Their endoglin and obestatin levels and biochemical parameters were measured. The carotid intima media thickness (cIMT) and brachial artery flow-mediated dilatation (FMD) responses were evaluated...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Sehee Kim, Chanyang Kim, Seungjoon Park
Adult hippocampal neurogenesis is decreased in type 2 diabetes, and this impairment appears to be important in cognitive dysfunction. Previous studies suggest that ghrelin gene products (acylated ghrelin (AG), unacylated ghrelin (UAG) and obestatin (OB)) promote neurogenesis. Therefore, we hypothesize that ghrelin gene products may reduce the harmful effects of high glucose (HG) on hippocampal neural stem cells (NSCs). The aim of this study was to investigate the role of these peptides on the survival of cultured hippocampal NSCs exposed to HG insult...
October 2016: Journal of Molecular Endocrinology
A Olszanecka, K Kawecka-Jaszcz, D Czarnecka
OBJECTIVE: Chemerin is recently identified adipose hormone, which plays a role in adipogenesis, energy metabolism and inflammation. Increased levels of chemerin have been linked to obesity and development of diabetes mellitus. During the transition from premenopause to postmenopause, many women experience weight gain and central fat deposition, hence we hypothesized that circulating level of chemerin can play a role in the pathogenesis of hypertension and cardiometabolic risk in postmenopausal females...
September 2016: Journal of Hypertension
Elaine Cowan, Praveen Kumar, Kerry J Burch, David J Grieve, Brian D Green, Stewart F Graham
INTRODUCTION: Obestatin is a controversial gastrointestinal peptide purported to have metabolic actions. OBJECTIVES: This study investigated whether treatment with a stable obestatin analogue (PEG-OB(Cys(10), Cys(13))) changed plasma metabolite levels firstly in lean and subsequently in diet-induced obesity (DIO) C57BL6/J mice. METHODS: Untargeted LC-HRMS metabolomics experiments were carried out in ESI + mode with plasma extracts from both groups of animals...
2016: Metabolomics: Official Journal of the Metabolomic Society
Xianhui Xu, Jianli Wang, Ling Li, Chunbin Wang, Weihua Li, Qin Zhang, Linghui Yang
AIMS: Roux-en-Y gastric bypass (RYGB) is a novel therapy for diabetes and the exact mechanisms of this procedure remain unclear. Obestatin is an important gut hormone. We aimed to explore the role of obestatin in the therapeutic mechanism of RYGB. METHODS: Twenty obese Zucker rats and twenty Wistar rats were randomly assigned to two groups: RYGB and sham surgery. We evaluated plasma obestatin and insulin levels pre- and post-RYGB. Additionally, obestatin expression levels in the gastrointestinal tract were assessed using immunohistochemical staining...
September 2016: Diabetes Research and Clinical Practice
Elda Leonor Pacheco-Pantoja, Jane P Dillon, Peter J M Wilson, William D Fraser, James A Gallagher
It is widely accepted that the c-Fos gene has a role in proliferation and differentiation of bone cells. ATP-induced c-Fos activation is relevant to bone homeostasis, because nucleotides that are present in the environment of bone cells can contribute to autocrine/paracrine signalling. Gut hormones have previously been shown to have an effect on bone metabolism. In this study, we used the osteoblastic Saos-2 cell line transfected with a c-Fos-driven reporter stimulated with five gut hormones: glucose inhibitory peptide (GIP), glucagon-like peptide-1 (GLP-1), glucagon-like peptide-2 (GLP-2), ghrelin and obestatin, in the presence or absence of ATP...
July 20, 2016: Purinergic Signalling
E S Motorykina, E A Khirazova, M V Maslova, A V Graf, A S Maklakova, A A Bayzhumanov, O D Kurko, L A Andreeva, N A Sokolova, N F Myasoedov, A A Kamenskii
Single administration of the obestatin fragment 1-4 (300 nmol/kg) to male Wistar rats produced a significant weight loss in male rats on observation days 5-8, while in female rats only on day 8. In addition, males demonstrated decreased risk factor in the elevated plus-maze test, but no effect of the preparation on behavior of female rats was revealed. Obestatin fragment 1-4 had no effect on corticosterone level 1 week after single administration in both females and male rats.
June 2016: Bulletin of Experimental Biology and Medicine
Maryam Razzaghy-Azar, Mitra Nourbakhsh, Abdolreza Pourmoteabed, Mona Nourbakhsh, Davod Ilbeigi, Mohsen Khosravi
BACKGROUND: Ghrelin is a 28-amino acid peptide with an orexigenic property, which is predominantly produced by the stomach. Acylated ghrelin is the active form of this hormone. Obestatin is a 23-amino acid peptide which is produced by post-translational modification of a protein precursor that also produces ghrelin. Obestatin has the opposite effect of ghrelin on food intake. The aim of this study was to evaluate acylated ghrelin and obestatin levels and their ratio in obese and normal-weight children and adolescents, and their association with metabolic syndrome (MetS) parameters...
2016: Journal of Clinical Medicine
Hong-Qi Li, Yuan-Bo Wu, Chang-Sen Yin, Li Chen, Qi Zhang, Li-Qun Hu
OBJECTIVE: The emergence of side-effect of doxorubicin in cardiomyopathy and heart failure has led to the search for diverse strategies to prevent its cytotoxic effects. This study was to determine the role of obestatin on doxorubicin-induced cardiomyocytes apoptosis and possible underlying mechanism. METHODS: Sprague Dawley rats were divided into 3 groups and received treatment for a total of 6 weeks: group1, untreated normal rats; group2, Doxorubicin-induced heart cardiomyopathy (DC) rats; and group3, obestatin treated HC rats...
July 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
U Dogan, H Y Ellidag, A Aslaner, T Cakir, M T Oruc, U Koc, B Mayir, I Gomceli, N Bulbuller, N Yılmaz
OBJECTIVE: To investigate the effect of laparoscopic sleeve gastrectomy (LSG) on the levels of obestatin and ghrelin hormones and body mass index (BMI) in morbidly obese patients. PATIENTS AND METHODS: The study included 30 morbidly obese patients who had LSG. Five cc blood samples were taken from the patients preoperatively and at postoperative months 3 and 6. After serum extraction, the levels of obestatin and ghrelin hormones and the levels of fasting insulin and glucose were studied using the enzyme-linked immunosorbent assay (ELISA) method...
May 2016: European Review for Medical and Pharmacological Sciences
Gulfer Ozturk, A Seval Ozgu-Erdinc, Fatma Ucar, Zeynep Ginis, Gonul Erden, Nuri Danisman
BACKGROUND: Hyperemesis gravidarum (HG), which affects 0.3-2.3% of pregnancies, is defined as excessive vomiting during pregnancy and usually starts in week 4 or 5 of gestation. Symptoms include weight loss, dehydration, ketonaemia, ketonuria, fasting acidosis, alkalosis due to hydrochloric acid loss and hypokalaemia and its exact cause is unknown. The present study was undertaken to investigate the relationship between prealbumin, ghrelin, nesfatin-1 and obestatin concentrations in pregnancies associated with HG METHODS: : A total of 40 pregnant women with HG and 38 pregnant women without HG as controls, were included in this study...
May 27, 2016: Annals of Clinical Biochemistry
Monika Słupecka, Katarzyna Romanowicz, Jarosław Woliński
The study aims to establish the effect of a maternal high-fat diet on obestatin concentration, total ghrelin, and ghrelin/obestatin ratio during pregnancy and lactation of Wistar rats and their offspring in the first 21 days of life. On the mating day, females were randomly allocated and fed either a high-fat diet (30% of fat; HF) or breeding diet (5% fat; BD) till the 21st day of lactation. Hormones were analyzed in the blood plasma and milk of rat dams as well as in the blood plasma of their offspring. HF resulted in a significant decrease in obestatin level on the 14th day of lactation and elevation on the 21st day...
2016: International Journal of Endocrinology
Elaine Cowan, Kerry J Burch, Brian D Green, David J Grieve
Obestatin is a 23-amino acid C-terminally amidated gastrointestinal peptide derived from preproghrelin and which forms an α helix. Although obestatin has a short biological half-life and is rapidly degraded, it is proposed to exert wide-ranging pathophysiological actions. Whilst the precise nature of many of its effects is unclear, accumulating evidence supports positive actions on both metabolism and cardiovascular function. For example, obestatin has been reported to inhibit food and water intake, body weight gain and gastrointestinal motility and also to mediate promotion of cell survival and prevention of apoptosis...
July 2016: British Journal of Pharmacology
Pawel Antoni Kolodziejski, Ewa Pruszynska-Oszmalek, Maciej Sassek, Przemyslaw Kaczmarek, Dawid Szczepankiewicz, Maria Billert, Paweł Maćkowiak, Mathias Z Strowski, Krzysztof W Nowak
BACKGROUND: Obestatin plays a role in regulating, food intake, and energy expenditure. The role of obestatin and GPR39 receptor in obesity (DIO), type 1 (T1DM) and type 2 diabetes (T2DM) are still not well understood. METHODS: Using animal models of DIO, T1DM or T2DM (n = 14 per group), we studied the expression of obestatin, its precursor protein as well as GPR39 in tissues relevant for the regulation of glucose and lipid homeostasis. Furthermore, we measured changes of obestatin and ghrelin serum levels...
April 23, 2016: Journal of Diabetes
ShreeRanga Nagaraj, Uma V Manjappara
In an effort to mimic in part the redundancy of satiety peptides involved in energy homeostasis, the combined benefits of the well-established satiety peptide CCK8 and an apparently anorectic peptide obestatin were studied in Swiss albino mice. The optimal dose of obestatin that was required to give the most pronounced effect with CCK8 was worked out by varying the concentration of obestatin while keeping CCK8 concentration constant at 200 nmol/KgBW. Mice administered 160 nmol obestatin and 200 nmol CCK8 per kilogram body weight showed the most drastic reduction in food intake...
June 2016: Biochimie
Alexander V Sirotkin, Abdel Halim Harrath, Roland Grossmann
The aim of the present study was to examine the role and interrelationships between calorie restriction and obestatin in the control of hormone release by chicken ovarian tissue. For this purpose, we compared the release of progesterone (P), testosteron (T), estradiol (E), and arginine-vasotocin (AVT) by ovarian fragments isolated from chicken subjected and not subjested to food restriction, as well as the response of these ovarian fragments to obestatin additions.It was observed that food restriction promoted release of P, reduced output of T, but did not affect basal E and AVT release...
August 1, 2016: Poultry Science
Agnieszka Polkowska, Izabela Szczepaniak, Artur Bossowski
The increasing knowledge on the functions of gastric peptides and adipokines in the body allows the assumption of their major role linking the process of food intake, nutritional status, and body growth, largely through the regulation of glucose metabolism and insulin resistance. The aim of the study was the assessment of serum levels of selected gastric peptides and adipocytokines in children with type 1 diabetes, with respect to the disease duration. The study involved 80 children aged 4-18 years (M/F -37/43)...
2016: BioMed Research International
Duygu Udum, Deniz Belenli, Tuncay Ilhan, Nazmiye Gunes, Fusun Sonat, Murat Yalcin
Obestatin is described as an anorexigenic peptide, and has adverse effects of ghrelin. It has no inhibitory effects on acute/chronic food intake, and it has been reported by several researchers. The role of obestatin in metabolism is still not clear. In the present study, the purpose is to determine the effects of chronically administrated obestatin. For this purpose, (1 µmol/kg; i.p.) or ghrelin (1 µmol/kg; i.p.) and food restriction (24h fast:24h fed) on plasma obestatin, ghrelin, leptin, insulin, cholecystokinin (CCK) and glucose levels, and body weight gain were investigated for 14 days in mice...
2016: Protein and Peptide Letters
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