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Radiation-oncology

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https://www.readbyqxmd.com/read/29230127/intraarterial-liver-directed-therapies-the-role-of-interventional-oncology
#1
REVIEW
Jenson Ma, Juan Martin Gimenez, Tyler Sandow, Daniel Devun, David Kirsch, Paul Gulotta, Patrick Gilbert, Dennis Kay
Background: Since the early 1990s, the minimally invasive image-guided therapies used in interventional oncology to treat hepatocellular carcinoma have continued to evolve. Additionally, the range of applications has been expanded to the treatment of hepatic metastases from colorectal cancer, neuroendocrine tumors, cholangiocarcinoma, breast cancer, melanoma, and sarcoma. Methods: We searched the literature to identify publications from 1990 to the present on various image-guided intraarterial therapies and their efficacy, as well as their role in the management of primary and secondary liver malignancies...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29230093/tld-and-osld-dosimetry-systems-for-remote-audits-of-radiotherapy-external-beam-calibration
#2
P Alvarez, S F Kry, F Stingo, D Followill
The Imaging and Radiation Oncology Core QA Center in Houston (IROC-H) performs remote dosimetry audits of more than 20,000 megavoltage photon and electron beams each year. Both a thermoluminescent dosimeter (TLD-100) and optically stimulated luminescent dosimeter (OSLD; nanoDot) system are commissioned for this task, with the OSLD system being predominant due to the more time-efficient read-out process. The measurement apparatus includes 3 TLD or 2 OSLD in an acrylic mini-phantom, which are irradiated by the institution under reference geometry...
November 2017: Radiation Measurements
https://www.readbyqxmd.com/read/29225692/recent-advances-in-radiation-oncology
#3
REVIEW
Cristina Garibaldi, Barbara Alicja Jereczek-Fossa, Giulia Marvaso, Samantha Dicuonzo, Damaris Patricia Rojas, Federica Cattani, Anna Starzyńska, Delia Ciardo, Alessia Surgo, Maria Cristina Leonardi, Rosalinda Ricotti
Radiotherapy (RT) is very much a technology-driven treatment modality in the management of cancer. RT techniques have changed significantly over the past few decades, thanks to improvements in engineering and computing. We aim to highlight the recent developments in radiation oncology, focusing on the technological and biological advances. We will present state-of-the-art treatment techniques, employing photon beams, such as intensity-modulated RT, volumetric-modulated arc therapy, stereotactic body RT and adaptive RT, which make possible a highly tailored dose distribution with maximum normal tissue sparing...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29224827/humidification-mitigates-acute-mucosal-toxicity-during-radiotherapy-when-factoring-volumetric-parameters-trans-tasman-radiation-oncology-group-trog-radiohum-07-03-substudy
#4
A Macann, F Fauzi, J Simpson, G Sasso, H Krawitz, C Fraser-Browne, J Manitz, A Raith
PURPOSE/OBJECTIVE(S): To model in a subset of patients from TROG 07.03 managed at a single site the association between domiciliary based humidification use and mucositis symptom burden during radiotherapy (RT) for head and neck cancer (HNC) when factoring in volumetric radiotherapy parameters derived from tumour and normal tissue regions of interest. MATERIALS/METHODS: From June 2008 through June 2011, 210 patients with HNC receiving RT were randomised to either a control arm or humidification using the Fisher & Paykel Healthcare MR880 humidifier...
December 2017: Oral Oncology
https://www.readbyqxmd.com/read/29222711/%C3%A3-gro-survey-on-radiotherapy-capacity-in-austria-status-quo-and-estimation-of-future-demands
#5
Brigitte Zurl, Anja Bayerl, Alexander De Vries, Hans Geinitz, Robert Hawliczek, Tomas-Henrik Knocke-Abulesz, Peter Lukas, Richard Pötter, Wolfgang Raunik, Brigitte Scholz, Annemarie Schratter-Sehn, Felix Sedlmayer, Dietmar Seewald, Edgar Selzer, Karin S Kapp
BACKGROUND: A comprehensive evaluation of the current national and regional radiotherapy capacity in Austria with an estimation of demands for 2020 and 2030 was performed by the Austrian Society for Radiation Oncology, Radiobiology and Medical Radiophysics (ÖGRO). MATERIALS AND METHODS: All Austrian centers provided data on the number of megavoltage (MV) units, treatment series, fractions, percentage of retreatments and complex treatment techniques as well as the daily operating hours for the year 2014...
December 8, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/29218267/radiomics-in-precision-medicine-for-lung-cancer
#6
REVIEW
Julie Constanzo, Lise Wei, Huan-Hsin Tseng, Issam El Naqa
With the improvement of external radiotherapy delivery accuracy, such as intensity-modulated and stereotactic body radiation therapy, radiation oncology has recently entered in the era of precision medicine. Despite these precise irradiation modalities, lung cancers remain one of the most aggressive human cancers worldwide, possibly because of diverse genotypic alterations that drive and maintain lung tumorigenesis. It has been long recognized that imaging could aid in the diagnosis, tumor delineation, and monitoring of lung cancer...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29218265/the-role-of-imaging-and-radiation-oncology-core-for-precision-medicine-era-of-clinical-trial
#7
Ying Xiao, Mark Rosen
Imaging and Radiation Oncology Core (IROC) services have been established for the quality assurance (QA) of imaging and radiotherapy (RT) for NCI's Clinical Trial Network (NCTN) for any trials that contain imaging or RT. The randomized clinical trial is the gold standard for evidence-based medicine. QA ensures data quality, preventing noise from inferior treatments obscuring clinical trial outcome. QA is also found to be cost-effective. IROC has made great progress in multi-institution standardization and is expected to lead QA standardization, QA science in imaging and RT and to advance quality data analysis with big data in the future...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29217308/a-sustainable-model-for-peer-review-and-utility-of-at-a-glance-analysis-of-dose-volume-histogram-in-radiation-oncology
#8
Rahul P Bhandari, William N Duggar, Chunli Yang, Madhava R Kanakamedala, Satya Packianathan, Shankar P Giri, Sophy H Mangana, Robert M Allbright, Srinivasan Vijayakumar
No abstract text is available yet for this article.
December 4, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29208398/future-cancer-research-priorities-in-the-usa-a-lancet-oncology-commission
#9
REVIEW
Elizabeth M Jaffee, Chi Van Dang, David B Agus, Brian M Alexander, Kenneth C Anderson, Alan Ashworth, Anna D Barker, Roshan Bastani, Sangeeta Bhatia, Jeffrey A Bluestone, Otis Brawley, Atul J Butte, Daniel G Coit, Nancy E Davidson, Mark Davis, Ronald A DePinho, Robert B Diasio, Giulio Draetta, A Lindsay Frazier, Andrew Futreal, Sam S Gambhir, Patricia A Ganz, Levi Garraway, Stanton Gerson, Sumit Gupta, James Heath, Ruth I Hoffman, Cliff Hudis, Chanita Hughes-Halbert, Ramy Ibrahim, Hossein Jadvar, Brian Kavanagh, Rick Kittles, Quynh-Thu Le, Scott M Lippman, David Mankoff, Elaine R Mardis, Deborah K Mayer, Kelly McMasters, Neal J Meropol, Beverly Mitchell, Peter Naredi, Dean Ornish, Timothy M Pawlik, Jeffrey Peppercorn, Martin G Pomper, Derek Raghavan, Christine Ritchie, Sally W Schwarz, Richard Sullivan, Richard Wahl, Jedd D Wolchok, Sandra L Wong, Alfred Yung
We are in the midst of a technological revolution that is providing new insights into human biology and cancer. In this era of big data, we are amassing large amounts of information that is transforming how we approach cancer treatment and prevention. Enactment of the Cancer Moonshot within the 21st Century Cures Act in the USA arrived at a propitious moment in the advancement of knowledge, providing nearly US$2 billion of funding for cancer research and precision medicine. In 2016, the Blue Ribbon Panel (BRP) set out a roadmap of recommendations designed to exploit new advances in cancer diagnosis, prevention, and treatment...
November 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29205797/stereotactic-ablative-radiotherapy-for-hepatocellular-carcinoma-history-current-status-and-opportunities
#10
REVIEW
Jeffrey Meyer, Amit G Singal
A variety of surgical and other local-regional approaches to the management of hepatocellular carcinoma are in clinical use. External beam radiation therapy is a relative newcomer to the portfolio of treatment options. Advances in planning and delivery of radiation therapy, developing in parallel with and inspiring changing paradigms of tumor management in the field of radiation oncology, have led to growing interest in radiation therapy as a viable treatment option for hepatocellular carcinoma as well as other liver tumors...
December 5, 2017: Liver Transplantation
https://www.readbyqxmd.com/read/29203269/clinically-localized-prostate-cancer-aua-astro-suo-guideline-part-i
#11
Martin G Sanda, Jeffrey A Cadeddu, Erin Kirkby, Ronald C Chen, Tony Crispino, Joann Fontanarosa, Stephen J Freedland, Kirsten Greene, Laurence H Klotz, Danil V Makarov, Joel B Nelson, George Rodrigues, Howard M Sandler, Mary Ellen Taplin, Jonathan R Treadwell
PURPOSE: This guideline is structured to provide a clinical framework stratified by cancer severity to facilitate care decisions and guide the specifics of implementing the selected management options. The summary presented herein represents Part I of the two-part series dedicated to Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline discussing risk stratification and care options by cancer severity. Please refer to Part II for discussion of specific care options and outcome expectations and management...
December 1, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29198341/concomitant-use-of-corticosteroids-and-immune-checkpoint-inhibitors-in-patients-with-hematologic-or-solid-neoplasms-a-systematic-review
#12
REVIEW
A Garant, C Guilbault, T Ekmekjian, Z Greenwald, P Murgoi, T Vuong
PURPOSE: Clinical trials studying immune checkpoint inhibitors exclude patients on corticosteroids, due to the hypothesis that corticosteroids may antagonize immunotherapy. We performed a systematic review of the literature looking at the clinical outcomes of cancer patients treated with immune checkpoint inhibitors and concomitant corticosteroids. METHODS: The following databases were searched for relevant studies: MEDLINE, Embase Classic+Embase, BIOSIS Previews, the Cochrane Database of Systematic Reviews, the CENTRAL Registry of Controlled Trials, Web of Science and Scopus...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29189448/tumor-boost-using-external-beam-radiation-in-cervical-cancer-patients-unable-to-receive-intracavitary-brachytherapy-outcome-from-a-multicenter-retrospective-study-korean-radiation-oncology-group-1419
#13
Haeyoung Kim, Young Seok Kim, Ji Hyeon Joo, Keun-Yong Eom, Won Park, Jin Hee Kim, Jong Hoon Lee, Yeon Sil Kim, Seok Ho Lee, Kijung Ahn, Yong Bae Kim, Me-Yeon Lee, Sei Kyung Chang
PURPOSE: We conducted this study to evaluate the outcomes of external-beam radiotherapy tumor boost (EBRT-B) in cervical cancer patients who could not receive intracavitary brachytherapy. METHODS: A total of 11 hospitals provided the data of patients who received EBRT-B during the period from January 2005 through October 2012. RESULTS: A total of 75 patients were included. The median radiotherapy dose was 46 Gy (range, 40-54 Gy) for whole pelvis and 24 Gy (range, 9-35 Gy) for EBRT-B...
November 17, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29189093/a-palliative-radiation-oncology-consult-service-s-impact-on-care-of-advanced-cancer-patients
#14
Sanders Chang, Peter May, Nathan E Goldstein, Juan Wisnivesky, Kenneth Rosenzweig, R Sean Morrison, Kavita V Dharmarajan
INTRODUCTION: Palliative radiation therapy (PRT) is a commonly utilized intervention for symptom palliation among patients with metastatic cancer, yet it is under-recognized as a distinct area of subspecialty within radiation oncology. OBJECTIVE: We developed a multidisciplinary service model within radiation oncology called the Palliative Radiation Oncology Consult (PROC) service to improve the quality of cancer care for advanced cancer patients. We assessed the service's impact on patient-related and healthcare utilization outcomes...
November 30, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29180076/delineation-of-the-primary-tumour-clinical-target-volumes-ctv-p-in-laryngeal-hypopharyngeal-oropharyngeal-and-oral-cavity-squamous-cell-carcinoma-airo-caca-dahanca-eortc-georcc-gortec-hknpcsg-hncig-iag-kht-lprhht-ncic-ctg-ncri-nrg-oncology-phns-sbrt-somera
#15
Vincent Grégoire, Mererid Evans, Quynh-Thu Le, Jean Bourhis, Volker Budach, Amy Chen, Abraham Eisbruch, Mei Feng, Jordi Giralt, Tejpal Gupta, Marc Hamoir, Juliana K Helito, Chaosu Hu, Keith Hunter, Jorgen Johansen, Johannes Kaanders, Sarbani Ghosh Laskar, Anne Lee, Philippe Maingon, Antti Mäkitie, Francesco Micciche', Piero Nicolai, Brian O'Sullivan, Adela Poitevin, Sandro Porceddu, Krzysztof Składowski, Silke Tribius, John Waldron, Joseph Wee, Min Yao, Sue S Yom, Frank Zimmermann, Cai Grau
PURPOSE: Few studies have reported large inter-observer variations in target volume selection and delineation in patients treated with radiotherapy for head and neck squamous cell carcinoma. Consensus guidelines have been published for the neck nodes (see Grégoire et al., 2003, 2014), but such recommendations are lacking for primary tumour delineation. For the latter, two main schools of thoughts are prevailing, one based on geometric expansion of the Gross Tumour Volume (GTV) as promoted by DAHANCA, and the other one based on anatomical expansion of the GTV using compartmentalization of head and neck anatomy...
November 24, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29177202/applying-physical-science-techniques-and-cern-technology-to-an-unsolved-problem-in-radiation-treatment-for-cancer-the-multidisciplinary-voxtox-research-programme
#16
Neil G Burnet, Jessica E Scaife, Marina Romanchikova, Simon J Thomas, Amy M Bates, Emma Wong, David J Noble, Leila Ea Shelley, Simon J Bond, Julia R Forman, Andrew Cf Hoole, Gillian C Barnett, Frederic M Brochu, Michael Pd Simmons, Raj Jena, Karl Harrison, Ping Lin Yeap, Amelia Drew, Emma Silvester, Patrick Elwood, Hannah Pullen, Andrew Sultana, Shannon Yk Seah, Megan Z Wilson, Simon G Russell, Richard J Benson, Yvonne L Rimmer, Sarah J Jefferies, Nicolette Taku, Mark Gurnell, Andrew S Powlson, Carola-Bibiane Schönlieb, Xiaohao Cai, Michael Pf Sutcliffe, Michael A Parker
The VoxTox research programme has applied expertise from the physical sciences to the problem of radiotherapy toxicity, bringing together expertise from engineering, mathematics, high energy physics (including the Large Hadron Collider), medical physics and radiation oncology. In our initial cohort of 109 men treated with curative radiotherapy for prostate cancer, daily image guidance computed tomography (CT) scans have been used to calculate delivered dose to the rectum, as distinct from planned dose, using an automated approach...
June 2017: CERN IdeaSquare Journal of Experimental Innovation
https://www.readbyqxmd.com/read/29174470/associations-between-prostate-volume-and-oncologic-outcomes-in-men-undergoing-focal-cryoablation-of-the-prostate
#17
Ahmed Elshafei, Kae Jack Tay, Onder Kara, Ercan Malkoc, Yaw Nyame, Hans Arora, Asmaa Hatem, Sahil A Patel, Franco Lugnani, Thomas J Polascik, J Stephen Jones
INTRODUCTION: The purpose of this study was to assess the relationship of total prostate volume (TPV) and oncologic outcomes following focal prostate cryoablation. MATERIALS AND METHODS: A query of the Cryo On-Line Database (COLD) registry for men who underwent primary focal prostate cryoablation revealed 829 patients with complete data. The impact of TPV on oncologic outcomes including progression-free survival (PFS) and post-cryoablation biopsy outcome was assessed using Kaplan-Meier curves and Cox and logistic regression models...
October 28, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29165809/medical-industry-at-tumor-board-three-years-analysis-of-the-open-payments-database-and-comparison-of-oncologic-specialties
#18
Amanjit S Baadh, Mikin Patel, Ketan Patel, Osman Ahmed
BACKGROUND AND OBJECTIVES: To analyze and contrast medical industry payments across U.S. oncologic providers, including hematology-oncology (HO), surgical oncology (SO), interventional radiology (IR), and radiation oncology (RO). METHODS: Open-payment-data for each provider including provider specialty, state of practice, industry payor, reason for payment, and amount was compiled for each transaction between 2013 and 2015. Total, mean, and median payment amounts per-provider were calculated for each specialty...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165280/radiation-oncology-needs-to-adopt-a-comprehensive-standard-for-data-transfer-the-case-for-hl7-fhir
#19
EDITORIAL
Mark Phillips, Lia Halasz
No abstract text is available yet for this article.
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29165279/letter-from-puerto-rico-the-state-of-radiation-oncology-after-maria-s-landfall
#20
EDITORIAL
Javier Lopez-Araujo, O Lee Burnett
No abstract text is available yet for this article.
December 1, 2017: International Journal of Radiation Oncology, Biology, Physics
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