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Allergic skin disease

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https://www.readbyqxmd.com/read/28449362/duration-and-exclusiveness-of-breastfeeding-and-risk-of-childhood-atopic-diseases
#1
Niels J Elbert, Evelien R van Meel, Herman T den Dekker, Nicolette W de Jong, Tamar E C Nijsten, Vincent W V Jaddoe, Johan C de Jongste, Suzanne G M A Pasmans, Liesbeth Duijts
BACKGROUND: Breastfeeding may have immune modulatory effects that influence the development of childhood allergic sensitization and atopic diseases. We aimed to examine the associations of breastfeeding with childhood allergic sensitization, inhalant or food allergy and eczema, and whether any association was affected by disease-related modification of the exposure or modified by maternal history of maternal history of allergy, eczema or asthma. METHODS: This study among 5,828 children was performed in a population-based prospective cohort from fetal life onwards...
April 27, 2017: Allergy
https://www.readbyqxmd.com/read/28440548/contact-sensitizers-trigger-human-cd1-autoreactive-t-cell-responses
#2
Richard J Betts, Adrijana Perkovic, Subhashree Mahapatra, Aurélia Del Bufalo, Kaddy Camara, Amy R Howell, Silvia Martinozzi Teissier, Gennaro De Libero, Lucia Mori
Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Exposure of human antigen-presenting cells such as monocyte-derived dendritic cells and THP-1 cells to the prototypical contact sensitizer dinitrochlorobenzene potentiated the response of CD1a- and CD1d-autoreactive T cells, which released a vast array of cytokines in a CD1- and TCR-dependent manner...
April 25, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28435394/the-role-of-mast-cells-in-oral-squamous-cell-carcinoma
#3
REVIEW
Swetha Gudiseva, Arvind Babu Rajendra Santosh, Raviteja Chitturi, Vamsikrishna Anumula, Chandrashekar Poosarla, Venkat Ramana Reddy Baddam
The mast cells are initial effective lineage in both humoral and adaptive immunity. They are ubiquitous in skin, mucosa, and in function. They contain biologically essential and dynamic mediators in healthy and harmful conditions of tissue. Mast cell malfunctioning could be attributed to various chronic allergic diseases. Considerately, emerging evidence of mast cell involvement in various cancers shows them to have both positive and negative roles in tumour growth. It mostly indulges in tumour progression and metastasis via angiogenesis, extracellular matrix degradation, and mitogenic activity in the tumour microenvironment...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/28425257/role-of-hygienic-factors-in-the-etiology-of-allergic-disorders-in-children
#4
Şule Yeşil, Ahmet Kan, Olkar Abdulmajed, Arzu Bakirtaş, Nedim Sultan, Sadık M Demirsoy
BACKGROUND/AIM: We investigated the role of body flora and chronic inflammatory infections in the etiology of allergic disorders in Turkish children. MATERIALS AND METHODS: Forty pediatric asthma patients with positive skin prick tests and 40 age-matched healthy subjects with negative skin prick tests were enrolled in this cross-sectional study. Serum H. pylori IgG, viral hepatitis serology, IL-10, and TGF-beta levels were measured. Stool and throat cultures were taken and tested for occurrence of microorganisms...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28413317/korean-red-ginseng-improves-atopic-dermatitis-like-skin-lesions-by-suppressing-expression-of-proinflammatory-cytokines-and-chemokines-in%C3%A2-vivo-and-in%C3%A2-vitro
#5
Ji-Ye Kee, Yong-Deok Jeon, Dae-Seung Kim, Yo-Han Han, Jinbong Park, Dong-Hyun Youn, Su-Jin Kim, Kwang Seok Ahn, Jae-Young Um, Seung-Heon Hong
BACKGROUND: The prevalence of allergic inflammatory diseases such as atopic dermatitis (AD), asthma, and allergic rhinitis worldwide has increased and complete recovery is difficult. Korean Red Ginseng, which is the heat-processed root of Panax ginseng Meyer, is widely and frequently used as a traditional medicine in East Asia. In this study, we investigated whether Korean Red Ginseng water extract (RGE) regulates the expression of proinflammatory cytokines and chemokines via the mitogen-activated protein kinases (MAPKs)/nuclear factor kappa B (NF-κB) pathway in allergic inflammation...
April 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/28412864/cutaneous-allergic-drug-reactions-update-on-pathophysiology-diagnostic-procedures-and-differential-diagnostic
#6
Galina Balakirski, Hans F Merk
Important changes in the understanding and management of drug hypersensitivity reactions during the last years result from the increasing importance of biologics in medical practice, which differ in their spectrum of adverse drug reactions (ADRs) from the classical covalent drugs. With regard to covalent drugs, ampicillin and amoxicillin as well as clavulanic acid play an increasing role among ADRs to betalactam antibiotics. Fluoroquinolones are mainly the cause of anaphylactic and photosensitivity reactions...
April 17, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28410872/prevalence-and-risk-factors-for-wheezing-and-allergic-diseases-in-preschool-children-a-perspective-from-the-mediterranean-coast-of-turkey
#7
E Bolat, T Arikoglu, M A Sungur, S B Batmaz, S Kuyucu
OBJECTIVES: The aim of the present study was to determine the prevalence and risk factors of allergic diseases in preschool children from one of the biggest cities in the Mediterranean Region of Turkey. METHODS: The study population included 396 preschool children attending to urban daycare centres in Mersin. In the first stage, a comprehensive standardised questionnaire modified from the International Study of Asthma and Allergies in Childhood (ISAAC) was employed...
April 11, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28408397/the-il-31-il-31-receptor-axis-general-features-and-role-in-tumor-microenvironment
#8
REVIEW
Elisa Ferretti, Anna Corcione, Vito Pistoia
IL-31 is a recently identified cytokine with a well-defined role in the pathogenesis of pruritus. IL-31, whose production is induced by IL-4 and IL-33, binds a heterodimeric receptor (R) composed of the exclusive IL-31RA chain and the shared oncostatin M R. Signaling through the IL-31R involves the MAPK, PI3K/AKT and Jak/STAT pathways. Different variants and isoforms of IL-31RA with different signaling activities have been identified. IL-31 is produced predominantly by circulating Th2 lymphocytes and skin-homing CLA(+)CD45RO(+) T cells...
April 13, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28396898/-allergic-contact-dermatitis-of-the-scalp
#9
REVIEW
L Koch, W Aberer
Contact allergy represents an important differential diagnosis to other skin diseases of the scalp. The typical efflorescences, spreading in the periphery, pruritus, and the clinical history support the differential diagnosis. Since the scalp is particularly resistant to contact dermatitis, allergens applied to this area often produce dermatitis of the eyelids, ears and neck. Nevertheless, potent allergens such as para-phenylendiamine can also cause severe reactions of the scalp. The most important allergens eliciting contact allergy of the scalp are found in bleaches and dyes, shampoos and conditioners, products for perm waves and straighteners as well as topical drugs...
April 10, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28394773/occupational-contact-dermatitis-in-north-american-production-workers-referred-for-patch-testing-retrospective-analysis-of-cross-sectional-data-from-the-north-american-contact-dermatitis-group-1998-to-2014
#10
Erin M Warshaw, Solveig L Hagen, Joel G DeKoven, Kathryn A Zug, Denis Sasseville, Donald V Belsito, Matthew J Zirwas, Joseph F Fowler, James S Taylor, Anthony F Fransway, Vincent A DeLeo, James G Marks, Melanie D Pratt, Howard I Maibach, C G Toby Mathias
BACKGROUND: Little is known about the epidemiology of contact dermatitis in production workers (PWs). OBJECTIVE: The aims of this study were to estimate the prevalence of contact dermatitis and characterize clinically relevant and occupationally related allergens among North American PWs undergoing patch testing. METHODS: This was a retrospective cross-sectional analysis of North American Contact Dermatitis Group data from 1998 to 2014. RESULTS: Of 39,332 patch-tested patients, 2732 (7...
April 7, 2017: Dermatitis
https://www.readbyqxmd.com/read/28393056/report-of-common-aeroallergens-among-allergic-patients-in-northeastern-iran
#11
Yaghoub Mahboubi Oskouei, Reza Farid Hosseini, Hamid Ahanchian, Lida Jarahi, Nazila Ariaee, Farahzad Jabbari Azad
INTRODUCTION: The prevalence of atopic diseases has increased in recent decades dramatically. The most common aeroallergens in Northeastern Iran have not been fully defined. Determining the most common aeroallergens in allergic patients based on the skin prick test (SPT) was aimed in this investigation. MATERIALS AND METHODS: This cross-sectional study enrolled 1,006 allergic patients (aged 1-86 years) from October 2010 to February 2014 referred to the Allergy clinics of Mashhad University of Medical Science...
March 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28392911/early-childhood-risk-factors-for-rhinoconjunctivitis-in-adolescence-a-prospective-birth-cohort-study
#12
Elisabeth Soegaard Christiansen, Henrik Fomsgaard Kjaer, Esben Eller, Carsten Bindslev-Jensen, Arne Høst, Charlotte Gotthard Mortz, Susanne Halken
BACKGROUND: Rhinoconjunctivitis is a global health problem and one of the most common chronic conditions in children. Development of rhinoconjunctivitis depends on both genetic and environmental factors. Many studies have investigated rhinoconjunctivitis, but only few studies have evaluated the risk factors for non-allergic rhinoconjunctivitis in children finding family history of atopic diseases and gender to be of importance. The aim of this study was to investigate possible risk factors in early life for rhinoconjunctivitis, allergic as well as non-allergic, in adolescence...
2017: Clinical and Translational Allergy
https://www.readbyqxmd.com/read/28392290/association-between-atopic-dermatitis-and-contact-sensitization-a-systematic-review-and-meta-analysis
#13
Carsten R Hamann, Dathan Hamann, Alexander Egeberg, Jeanne D Johansen, Jonathan Silverberg, Jacob P Thyssen
BACKGROUND: It is unclear whether patients with atopic dermatitis (AD) have an altered prevalence or risk for contact sensitization. Increased exposure to chemicals in topical products together with impaired skin barrier function suggest a higher risk, whereas the immune profile suggests a lower risk. OBJECTIVE: To perform a systematic review and meta-analysis of the association between AD and contact sensitization. METHODS: The PubMed/Medline, Embase, and Cochrane databases were searched for articles that reported on contact sensitization in individuals with and without AD...
April 6, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28390860/basophil-derived-interleukin-4-promotes-epicutaneous-antigen-sensitization-concomitant-with-the-development-of-food-allergy
#14
Maryam Hussain, Loïc Borcard, Kevin P Walsh, Maria Pena Rodriguez, Christoph Mueller, Brian S Kim, Masato Kubo, David Artis, Mario Noti
BACKGROUND: Exaggerated TSLP production and infiltration of basophils are associated with the pathogenesis of atopic dermatitis (AD), a recognized risk factor for the development of food allergies. While TSLP and basophils have been implicated to promote food-induced allergic disorders in response to epicutaneous sensitization, the mechanisms by which TSLP-elicited basophils guide the progression of allergic inflammation in the skin to distant mucosal sites such as the gastrointestinal tract are poorly understood...
April 5, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28390586/an-analysis-of-anaphylaxis-cases-at-a-single-pediatric-emergency-department-during-a-1-year-period
#15
Christopher D Wright, Mindy Longjohn, Phillip L Lieberman, Jay Adam Lieberman
BACKGROUND: Case series of anaphylaxis can vary regarding causes, treatments, and follow-up of patients. Unfortunately, case series that are specific to the pediatric population are few. OBJECTIVE: To describe confirmed cases of pediatric anaphylaxis in patients presenting to a pediatric hospital emergency department (ED). METHODS: We identified all ED visits with the International Classification of Diseases, Ninth Revision (ICD-9) codes 995...
April 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28386956/comparison-of-cellular-location-and-expression-of-plakophilin-2-in-epidermal-cells-from-nonlesional-atopic-skin-and-healthy-skin-in-german-shepherd-dogs
#16
Brita Ardesjö-Lundgren, Katarina Tengvall, Kerstin Bergvall, Fabiana H G Farias, Liya Wang, Åke Hedhammar, Kerstin Lindblad-Toh, Göran Andersson
BACKGROUND: Canine atopic dermatitis (CAD) is an inflammatory and pruritic allergic skin disease caused by interactions between genetic and environmental factors. Previously, a genome-wide significant risk locus on canine chromosome 27 for CAD was identified in German shepherd dogs (GSDs) and Plakophilin-2 (PKP2) was defined as the top candidate gene. PKP2 constitutes a crucial component of desmosomes and also is important in signalling, metabolic and transcriptional activities. OBJECTIVES: The main objective was to evaluate the role of PKP2 in CAD by investigating PKP2 expression and desmosome structure in nonlesional skin from CAD-affected (carrying the top GWAS SNP risk allele) and healthy GSDs...
April 6, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28380482/allergic-and-nonallergic-asthma-have-distinct-phenotypic-and-genotypic-features
#17
Priscila Takejima, Rosana Câmara Agondi, Helcio Rodrigues, Marcelo Vivolo Aun, Jorge Kalil, Pedro Giavina-Bianchi
BACKGROUND: Identification of asthma phenotypes enables a better understanding and management of this heterogeneous disease. Studies have reported associations between human leukocyte antigens (HLA) and asthma in different populations, but the results have been inconclusive and they have rarely considered the distinct disease phenotypes. Our objective was to characterize allergic and nonallergic asthma phenotypes and evaluate possible associations with the HLA system. METHODS: A total of 109 patients with asthma were prospectively followed during 2 years...
April 6, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28378554/reference-values-and-utility-of-serum-total-immunoglobulin-e-for-predicting-atopy-and-allergic-diseases-in-korean-schoolchildren
#18
Hye Young Kim, Jaehee Choi, Kangmo Ahn, Myung Il Hahm, So Yeon Lee, Woo Kyung Kim, Yoomi Chae, Yong Mean Park, Man Yong Han, Kee Jae Lee, Ho Jang Kwon, Seonwoo Kim, Heejin Yoo, Jihyun Kim
The present study aimed to investigate the distribution of total serum immunoglobulin E (IgE) levels in Korean schoolchildren and to evaluate its utility in the prediction of atopy and allergic diseases. A nationwide, cross-sectional survey was conducted in first grade students from randomly selected elementary and middle schools. Total IgE levels were measured by ImmunoCAP. Skin prick tests were performed for 18 common inhalant allergens to determine the presence of atopy. Children aged 12-13 years and parents of children aged 6-7 years were asked to complete questionnaire assessing allergic diseases...
May 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28375932/outstanding-animal-studies-in-allergy-ii-from-atopic-barrier-and-microbiome-to-allergen-specific-immunotherapy
#19
Erika Jensen-Jarolim, Isabella Pali-Schöll, Franziska Roth-Walter
PURPOSE OF REVIEW: Animal studies published within the past 18 months were assessed, focusing on innate and specific immunomodulation, providing knowledge of high translational relevance for human atopic and allergic diseases. RECENT FINDINGS: Allergic companion animals represent alternative models, but most studies were done in mice. Atopic dermatitis mouse models were refined by the utilization of cytokines like IL-23 and relevant skin allergens or enzymes. A novel IL-6 reporter mouse allows biomonitoring of inflammation...
June 2017: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28364972/association-of-atopy-phenotypes-with-new-development-of-asthma-and-bronchial-hyperresponsiveness-in-school-aged-children
#20
Eun Lee, Si Hyeon Lee, Young-Ho Kim, Hyun-Ju Cho, Jisun Yoon, Song-I Yang, Young-Ho Jung, Hyung Young Kim, Ju-Hee Seo, Ji-Won Kwon, Hyo-Bin Kim, So Yeon Lee, Ho-Jang Kwon, Soo-Jong Hong
BACKGROUND: Although previous studies have investigated the association between atopy phenotypes and allergic diseases, atopy characterizations in association with the development of allergic diseases remain poorly understood. OBJECTIVE: To identify atopy phenotypes in school-age children and to evaluate the association between atopy phenotypes and allergic diseases. METHODS: We enrolled 616 children with atopy defined as 1 or more positive allergen responses on skin prick tests and 665 children without atopy from the Children's Health and Environmental Research (CHEER) study...
March 29, 2017: Annals of Allergy, Asthma & Immunology
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