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Allergic skin disease

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https://www.readbyqxmd.com/read/28727909/positive-allergen-reaction-in-allergic-and-nonallergic-rhinitis-a-systematic-review
#1
Aneeza W Hamizan, Janet Rimmer, Raquel Alvarado, William A Sewell, Larry Kalish, Raymond Sacks, Richard J Harvey
BACKGROUND: The diagnosis of allergic rhinitis (AR) is based on cutaneous and serological assessment to determine immunoglobulin E (IgE)-mediated disease. However, discrepancies between these tests and nasal provocation exist. Patients diagnosed as non-allergic rhinitis (NAR) but with positive nasal allergen provocation test (NAPT) may represent a local allergic condition or entopy, still suitable to allergy interventions. The objective of this study was to determine the frequency of nasal reactivity toward allergens among AR and NAR patients, and to describe the diagnostic characteristics of NAPT methodologies...
July 20, 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28716173/central-compartment-atopic-disease
#2
John M DelGaudio, Patricia A Loftus, Aneeza W Hamizan, Richard J Harvey, Sarah K Wise
BACKGROUND: Isolated polypoid changes of the middle turbinate were recently reported as having a high association with inhalant allergy. A more advanced manifestation of this association may present as polypoid changes of the entire central sinonasal compartment (i.e., the middle and superior turbinates, and the posterosuperior nasal septum), while the lateral sinus mucosa remains relatively normal. OBJECTIVE: To introduce and describe this newly recognized variant of chronic rhinosinusitis (CRS), termed central compartment atopic disease (CCAD)...
July 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28707710/perception-and-image-of-dermatology-in-the-german-general-population-2002-2014
#3
M Augustin, L Eissing, P Elsner, K Strömer, I Schäfer, A Enk, M Reusch, R Kaufmann
BACKGROUND: In contrast to other European countries, dermatologists in Germany provide healthcare for a broad spectrum of diseases of the skin and mucous membranes. Current population-based data on the perception of dermatology were lacking to date. OBJECTIVE: Analysis of the perception of dermatology from the general population's perspective with regard to utilization, satisfaction, and responsibility. METHODS: Nation-wide survey on awareness, utilization, rating, and image of dermatology in Oct/2014 through computer-assisted telephone interviews on a representative sample of the adult general population (n = 1,015), performed by the FORSA institute...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28702111/innate-function-of-house-dust-mite-allergens-robust-enzymatic-degradation-of-extracellular-matrix-at-elevated-ph
#4
Kumiko Oida, Lukas Einhorn, Ina Herrmann, Lucia Panakova, Yvonne Resch, Susanne Vrtala, Gerlinde Hofstetter, Akane Tanaka, Hiroshi Matsuda, Erika Jensen-Jarolim
BACKGROUND: Exposure to the house dust mite Dermatophagoides pteronyssinus (D.p.) increases the risk for developing allergic diseases in humans and their best friends, the dogs. Here, we explored whether this allergenic mite via its enzymes may impact the cutaneous extracellular matrix (ECM), which critically determines epithelial barrier integrity both structurally and functionally. METHODS: Two extracts obtained from either dust-purified or cultured D.p. bodies were used in the present study...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28695805/clinical-analysis-of-77-patients-with-allergic-bronchopulmonary-aspergillosis-in-peking-union-medical-college-hospital
#5
Mingqiang Zhang, Jinming Gao
Objective To summarize the clinical features of allergic bronchopulmonary aspergillosis(ABPA)to facilitate its early diagnosis and treatment. Methods We retrospectively analyzed the clinical data of 77 patients who had been admitted to Peking Union Medical College Hospital from January 1996 to July 2015 with ABPA. Results The average age of these 77 patients(38 men and 39 women)was(41.8±18.3)years. The co-morbidities included bronchial asthma(n=74,96%)and pulmonary cystic fibrosis(n=3,4%). The main symptoms and signs of ABPA were chronic cough(100%),sputum production(97%),wheeze(86%),sputum plugs(25%),blood-stained sputum(18%),hemoptysis(9%),chest pain(9%),fever(47%),weight loss(30%),and night sweat(12%)...
June 20, 2017: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/28695412/-basis-for-the-treatment-of-eczematous-diseases-in-otorhinolaryngology
#6
REVIEW
R Fölster-Holst, A Sperl, T Albrecht, L Klimek
According to Coombs and Gell, cell-mediated immune responses belong to type IV reactions and are borne mainly by T lymphocytes. The eliciting allergens are usually so-called haptens. Haptens are substances which develop to whole antigens only by binding to protein carriers. In otorhinolaryngology, delayed allergic hypersensitivities are apparent mainly as contact eczemata. Facial dermatitis, auricle and ear canal eczema as well as perioral eczema belong to the most common forms of contact dermatitis in ENT patients...
July 10, 2017: HNO
https://www.readbyqxmd.com/read/28694031/in-vivo-induction-of-regulatory-t-cells-promotes-allergen-tolerance-and-suppresses-allergic-contact-dermatitis
#7
Stephen C Balmert, Cara Donahue, John R Vu, Geza Erdos, Louis D Falo, Steven R Little
Allergic contact dermatitis (ACD) is a common T-cell mediated inflammatory skin condition, characterized by an intensely pruritic rash at the site of contact with allergens like poison ivy or nickel. Current clinical treatments use topical corticosteroids, which broadly and transiently suppress inflammation and symptoms of ACD, but fail to address the underlying immune dysfunction. Here, we present an alternative therapeutic approach that teaches the immune system to tolerate contact allergens by expanding populations of naturally suppressive allergen-specific regulatory T cells (Tregs)...
July 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28689794/results-from-the-5-year-sq-grass-slit-tablet-asthma-prevention-gap-trial-in-children-with-grass-pollen-allergy
#8
Erkka Valovirta, Thomas Houmann Petersen, Teresa Piotrowska, Mette Kongensbjerg Laursen, Jens Strodl Andersen, Helle Frobøse Sørensen, Rabih Klink
BACKGROUND: Allergy immunotherapy targets the immunological cause of allergic rhinoconjunctivitis and allergic asthma and has the potential to alter the natural course of allergic disease. OBJECTIVE: The primary objective was to investigate the effect of the SQ grass SLIT-tablet compared to placebo on the risk of developing asthma. METHODS: 812 children (5-12 years), with a clinically relevant history of grass pollen allergic rhinoconjunctivitis and no medical history or signs of asthma, were included in the randomised, double-blind, placebo-controlled trial, comprising 3 years treatment and 2 years follow-up...
July 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28681396/association-of-atopy-and-tentative-diagnosis-of-skin-cancer-results-from-occupational-skin-cancer-screenings
#9
I Schäfer, P Mohr, N Zander, R Fölster-Holst, M Augustin
BACKGROUND: The relationship between atopic conditions and carcinoma of the skin has been described inconsistently. Population-based data providing information on atopic diseases as well as on skin-cancer are sparse. OBJECTIVE: To determine the correlation between atopy and prevalence of precanceroses, nonmelanoma skin-cancer and malignant melanoma (MM), while taking into account known risk factors for skin cancer. METHODS: Data from occupational skin cancer screenings were analysed in a cross-sectional study...
July 6, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28677275/ultraviolet-radiation-and-skin-mast-cells-effects-mechanisms-and-relevance-for-skin-diseases
#10
REVIEW
Hanna Siiskonen, Anna Smorodchenko, Karoline Krause, Marcus Maurer
Mast cells (MCs) are well-known as versatile effector cells in allergic reactions and several other immune responses. Skin MCs and cutaneous MC responses are subject to the effects of environmental factors including ultraviolet radiation (UVR). Numerous studies have assessed the effects of UVR on MCs, in vitro and in vivo. Interestingly, UVR seems to have variable effects on nonactivated and activated mast cells. In general, UV therapy is beneficial in the treatment of urticaria and mastocytosis, but the effects are variable depending on treatment regimen and type of UVR...
July 4, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28670256/contact-allergy-in-the-population-of-patients-with-chronic-inflammatory-dermatoses-and-contact-hypersensitivity-to-corticosteroids
#11
Marek Kot, Jarosław Bogaczewicz, Beata Kręcisz, Anna Woźniacka
INTRODUCTION: Clinical studies indicate that contact allergy to glucocorticosteroids (GCS) is not rare and has been increasingly reported over the past decade. Among the risk factors for developing contact hypersensitivity to topical corticosteroids, chronic inflammatory skin diseases and polyvalent contact allergy seem to be most important. AIM: To present the structure of contact allergy in the population of patients with chronic inflammatory dermatoses (CID) and contact hypersensitivity to corticosteroids...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28670248/allergic-contact-dermatitis-pattern-in-kuwait-nickel-leads-the-pack-in-depth-analysis-of-nickel-allergy-based-on-the-results-from-a-large-prospective-patch-test-series-report
#12
Nawaf Almutairi, Fahad Almutawa
INTRODUCTION: Contact dermatitis is a relatively common dermatosis reported among several population groups from all around the globe. However, the data from Kuwait is unavailable. Patch tests are essential for the diagnosis of contact sensitization. AIM: To determine a relative frequency and pattern of sensitizers to different allergens in patients of suspected contact dermatitis in Kuwait and, also to study the role of the commonest sensitizer in detail. MATERIAL AND METHODS: Patch tests were performed in 2461 consecutive patients with a clinical diagnosis of contact dermatitis seen at our hospital between September 1, 2014 and August 31, 2015...
June 2017: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/28669672/cutaneous-leishmaniasis-induces-a-transmissible-dysbiotic-skin-microbiota-that-promotes-skin-inflammation
#13
Ciara Gimblet, Jacquelyn S Meisel, Michael A Loesche, Stephen D Cole, Joseph Horwinski, Fernanda O Novais, Ana M Misic, Charles W Bradley, Daniel P Beiting, Shelley C Rankin, Lucas P Carvalho, Edgar M Carvalho, Phillip Scott, Elizabeth A Grice
Skin microbiota can impact allergic and autoimmune responses, wound healing, and anti-microbial defense. We investigated the role of skin microbiota in cutaneous leishmaniasis and found that human patients infected with Leishmania braziliensis develop dysbiotic skin microbiota, characterized by increases in the abundance of Staphylococcus and/or Streptococcus. Mice infected with L. major exhibit similar changes depending upon disease severity. Importantly, this dysbiosis is not limited to the lesion site, but is transmissible to normal skin distant from the infection site and to skin from co-housed naive mice...
June 22, 2017: Cell Host & Microbe
https://www.readbyqxmd.com/read/28668236/mammalian-raw-materials-used-to-produce-allergen-extracts
#14
Enrique Fernández-Caldas, Bárbara Cases, David El-Qutob, Jose Fernando Cantillo
OBJECTIVE: To provide information about the complexity of skin-derived mammalian allergen extracts and recent advances made in their characterization and production. DATA SOURCES: Original and review articles (involving nonfood allergy to mammals) published in indexed journals were searched in the PubMed database. STUDY SELECTIONS: Studies were selected with the following criteria: novelty, species of the study, and date of publication. RESULTS: The information provided will help in the understanding and the selection of the appropriate allergen source materials for the preparation of extracts for the diagnosis and treatment of allergic respiratory diseases induced by the inhalation of skin-derived mammalian allergens...
July 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28664215/anti-inflammatory-effect-of-galectin-1-in-a-murine-model-of-atopic-dermatitis
#15
Mab Pereira Corrêa, Frans Eberth Costa Andrade, Alexandre Dantas Gimenes, Cristiane Damas Gil
Atopic dermatitis (AD) is caused by both dysregulated immune responses and an impaired skin barrier. Although beta-galactoside-binding protein galectin-1 (Gal-1) has immunomodulatory effects in several inflammatory disorders, therapeutic strategies based on its anti-inflammatory properties have not been explored in AD. Thus, we evaluate pharmacological treatment with Gal-1 in the progression of an ovalbumin (OVA)-induced AD-like skin lesions. The skin of OVA-immunized male BALB/c mice was challenged with drops containing OVA on days 11, 14-18 and 21-24...
June 29, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28658723/sensitization-to-10-mites-in-a-tropic-area-der-p-and-der-f-are-important-risk-factor-for-sensitization-to-other-mites-from-pyroglyphidae-acaridae-chortoglyphidae-and-glyciphagidae-families
#16
Jorge Sánchez, Víctor Calvo, Andrés Sánchez, Susana Díez, Ricardo Cardona
BACKGROUND: Much is known about the frequency of sensitization to Blomia tropicalis, Dermatophagoides pteronyssinus and Dermatophagoides farinae, although less is known about sensitization to other species and their possible interactions. OBJECTIVE: In patients with allergic manifestations, to evaluate the frequency of sensitization to 10 species of mites in a tropical area and their possible interactions. METHODS: Cross-sectional study. Sensitization was evaluated by skin tests...
April 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28658721/-prevalence-of-allergic-diseases-in-children-with-secondary-renal-tubular-acidosis-attending-a-tertiary-care-pediatric-center
#17
Blanca María Morfín-Maciel, Silvestre García-De la Puente, Aurora Bojórquez-Ochoa, Alfonso Huante-Anaya, Socorro Orozco-Martínez, Samuel Zaltzman-Girshevich, Elizabeth Guzmán-Vázquez
BACKGROUND: It has been suggested a high prevalence of allergic disease in children with RTA. OBJECTIVE: To describe the prevalence of allergic diseases in children with secondary RTA (renal tubular acidosis) in the nephrology department of the National Institute of Pediatrics (NIP), México. METHODS: An observational, prospective, cross-sectional, descriptive study. Children with secondary RTA < 18 years who attended the outpatient nephrology service in the NIP for 24 months, were included...
April 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/28658558/the-atopic-march-current-insights-into-skin-barrier-dysfunction-and-epithelial-cell-derived-cytokines
#18
REVIEW
Hongwei Han, Florence Roan, Steven F Ziegler
Atopic dermatitis often precedes the development of other atopic diseases. The atopic march describes this temporal relationship in the natural history of atopic diseases. Although the pathophysiological mechanisms that underlie this relationship are poorly understood, epidemiological and genetic data have suggested that the skin might be an important route of sensitization to allergens. Animal models have begun to elucidate how skin barrier defects can lead to systemic allergen sensitization. Emerging data now suggest that epithelial cell-derived cytokines such as thymic stromal lymphopoietin (TSLP), IL-33, and IL-25 may drive the progression from atopic dermatitis to asthma and food allergy...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28658557/interplay-between-barrier-epithelial-cells-and-dendritic-cells-in-allergic-sensitization-through-the-lung-and-the-skin
#19
REVIEW
Julie Deckers, Karolien De Bosscher, Bart N Lambrecht, Hamida Hammad
The prevalence of asthma is increasing over the years and it has become obvious that a thorough understanding of mechanisms leading to Th2 sensitization and to asthma is urgently needed to provide better ways to treat the disease. This articles reviews the different players involved in the initiation of allergic reactions in the lung and in the skin, and highlights the importance of a crosstalk between antigen-presenting dendritic cells and structural cell-derived signals in this process. Our increasing understanding of these mechanisms indicates that structural cells, such as airway epithelial cells and skin keratinocytes, need to be considered as more than a simple physical barrier since they are very upstream of the entire Th2 cascade and therefore might represent crucial targets for new therapies...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28656964/il-33-promotes-gastrointestianl-allergy-in-a-tslp-independent-manner
#20
H Han, F Roan, L K Johnston, D E Smith, P J Bryce, S F Ziegler
Atopic dermatitis (AD) often precedes asthma and food allergy, indicating that epicutaneous sensitization to allergens may be important in the induction of allergic responses at other barrier surfaces. Thymic stromal lymphopoietin (TSLP) and interleukin (IL)-33 are two cytokines that may drive type 2 responses in the skin; both are potential targets in the treatment of allergic diseases. We tested the functional role of IL-33 and the interplay between IL-33 and TSLP in mouse models of atopic march and gastrointestinal (GI) allergy...
June 28, 2017: Mucosal Immunology
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