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Allergic skin disease

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https://www.readbyqxmd.com/read/28109169/maternal-psychiatric-symptoms-during-pregnancy-and-risk-of-childhood-atopic-diseases
#1
Niels J Elbert, Liesbeth Duijts, Herman T den Dekker, Nicolette W de Jong, Tamar E C Nijsten, Vincent W V Jaddoe, Johan C de Jongste, Roy Gerth van Wijk, Henning Tiemeier, Suzanne G M A Pasmans
BACKGROUND: Maternal psychiatric symptoms during pregnancy might affect the developing immune system and subsequent risk of childhood atopic diseases. OBJECTIVE: Our aim was to examine the associations of maternal psychiatric symptoms during pregnancy with allergic sensitization, allergy and eczema in children until age 10 years. METHODS: This study among 5,205 children was performed in a population-based prospective cohort from fetal life onwards...
January 21, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28106783/extract-of-polygala-tenuifolia-alleviates-stress-exacerbated-atopy-like-skin-dermatitis-through-the-modulation-of-protein-kinase-a-and-p38-mitogen-activated-protein-kinase-signaling-pathway
#2
Bongjun Sur, Bombi Lee, Ye Seul Yoon, Pooreum Lim, Riwon Hong, Mijung Yeom, Hyang Sook Lee, Hijoon Park, Insop Shim, Hyejung Lee, Young Pyo Jang, Dae-Hyun Hahm
Atopic dermatitis (AD) and stress create a vicious cycle: stress exacerbates atopic symptoms, and atopic disease elicits stress and anxiety. Targeting multiple pathways including stress and allergic inflammation is, therefore, important for treating AD. In this study, we investigated the remedial value of Polygala tenuifolia Willd. (PTW) for treating immobilization (IMO) stress-exacerbated atopy-like skin dermatitis and its underlying mechanism. Trimellitic anhydride (TMA) was applied to dorsal skin for sensitization and subsequently both ears for eliciting T-cell-dependent contact hypersensitivity in mice, which underwent 2 h-IMO stress and PTW administration for the latter 6 and 9 days in the ear exposure period of TMA, respectively...
January 18, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28106273/the-immunoglobulin-superfamily-member-cd200r-identifies-cells-involved-in-type-2-immune-responses
#3
Lars H Blom, Britta C Martel, Lau F Larsen, Camilla V Hansen, Malene P Christensen, Nanna Juel-Berg, Thomas Litman, Lars K Poulsen
BACKGROUND: The pathology of allergic diseases involves type 2 immune cells, such as Th2, ILC2, and basophils exerting their effect by production of IL-4, IL-5, and IL-13. However, surface receptors that are specifically expressed on type 2 immune cells are less well documented. The aim of this investigation was to identify surface markers associated with type 2 inflammation. METHODS: Naïve human CD4(+) T-cells were short-term activated in the presence or absence of IL-4, and analysed for expression of >300 cell-surface proteins...
January 20, 2017: Allergy
https://www.readbyqxmd.com/read/28101683/allergy-histamine-and-antihistamines
#4
Martin K Church
This chapter concentrates on the role in allergic disease of histamine acting on H1-receptors. It is clear that allergy has its roots in the primary parasite rejection response in which mast cell-derived histamine creates an immediate hostile environment and eosinophils are recruited for killing. This pattern is seen in allergic rhinitis where the early events of mucus production and nasal itching are primarily histamine mediated whereas nasal blockage is secondary to eosinophil infiltration and activation...
January 19, 2017: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/28097676/morbihan-disease-complicated-by-dermatosis-neglecta-a-unique-presentation
#5
Ariel E Eber, Stephanie Mlacker, Sebastian Verne, Robert Griffith, Jennifer Ledon, Marina Perper, Keyvan Nouri, Jeong Hee Cho-Vega
Morbihan disease (MD), also referred to as solid facial edema, or rosacea lymphedema, is a rare disorder that involves chronic erythema and solid edema of the cheeks, eyelids, forehead and glabella and may arise as a complication of acne vulgaris or rosacea. Of note, it may be the only initial presenting symptom of these associated diseases.1,2 Few cases have been described in the literature, since its first description by Robert Degos in 1957. The condition is characterized by its chronicity, a typical clinical appearance, and the lack of specific histopathologic or laboratory findings...
January 18, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28091126/association-between-perfluoroalkyl-substance-exposure-and-asthma-and-allergic-disease-in-children-as-modified-by-mmr-vaccination
#6
Clara Amalie Gade Timmermann, Esben Budtz-Jørgensen, Tina Kold Jensen, Christa Elyse Osuna, Maria Skaalum Petersen, Ulrike Steuerwald, Flemming Nielsen, Lars K Poulsen, Pál Weihe, Philippe Grandjean
Perfluoroalkyl substances (PFASs) are highly persistent chemicals that might be associated with asthma and allergy, but the associations remain unclear. Therefore, this study examined whether pre- and postnatal PFAS exposure was associated with childhood asthma and allergy. Measles, mumps, and rubella (MMR) vaccination in early life may have a protective effect against asthma and allergy, and MMR vaccination is therefore taken into account when evaluating these associations. In a cohort of Faroese children whose mothers were recruited during pregnancy, serum concentrations of five PFASs - Perfluorohexane sulfonic acid (PFHxS), perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) - were measured at three timepoints (maternal serum in pregnancy week 34-36 and child serum at ages 5 and 13 years) and their association with immunoglobulin E (IgE) (cord blood and at age 7 years) and asthma/allergic diseases (questionnaires at ages 5 and 13 years and skin prick test at age 13 years) was determined...
January 16, 2017: Journal of Immunotoxicology
https://www.readbyqxmd.com/read/28076799/adenylyl-cyclase-type-9-gene-polymorphisms-are-associated-with-asthma-and-allergy-in-brazilian-children
#7
Helena M P Teixeira, Neuza M Alcantara-Neves, Maurício Barreto, Camila A Figueiredo, Ryan S Costa
Asthma is a chronic inflammatory disease of the respiratory tract. This heterogeneous disease is caused by the interaction of interindividual genetic variability and environmental factors. The gene adenylyl cyclase type 9 (ADCY9) encodes a protein called adenylyl cyclase (AC), responsible for producing the second messenger cyclic AMP (cAMP). cAMP is produced by T regulatory cells and is involved in the down-regulation of T effector cells. Failures in cAMP production may be related to an imbalance in the regulatory immune response, leading to immune-mediated diseases, such as allergic disorders...
January 8, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28067304/weissella-cibaria-wikim28-ameliorates-atopic-dermatitis-like-skin-lesions-by-inducing-tolerogenic-dendritic-cells-and-regulatory-t-cells-in-balb-c-mice
#8
Seul Ki Lim, Min-Sung Kwon, Jieun Lee, Young Joon Oh, Ja-Young Jang, Jong-Hee Lee, Hae Woong Park, Young-Do Nam, Myung-Ji Seo, Seong Woon Roh, Hak-Jong Choi
The occurrence of atopic dermatitis (AD), a chronic inflammatory skin disease, has been increasing steadily in children and adults in recent decades. In this study, we evaluated the ability of the lactic acid bacterium Weissella cibaria WIKIM28 isolated from gatkimchi, a Korean fermented vegetable preparation made from mustard leaves, to suppress the development of AD induced by 2,4-dinitrochlorobenzene in a murine model. Oral administration of W. cibaria WIKIM28 reduced AD-like skin lesions, epidermal thickening, and serum immunoglobulin E levels...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28052797/involvement-of-micrornas-in-skin-disorders-a-literature-review
#9
Carmen Mannucci, Marco Casciaro, Paola L Minciullo, Gioacchino Calapai, Michele Navarra, Sebastiano Gangemi
BACKGROUND: miRNAs are a class of noncoding RNA molecules that modulate gene expression after transcription. It is known that miRNAs are involved in various cellular processes of both normal and diseased skin. Recently, differential expressions of miRNAs have been reported and associated with several immunologic and inflammatory disorders, which indicate a common role in fundamental biologic processes. OBJECTIVE: To collect and review data from the literature on involvement of miRNA in inflammatory skin disorders...
January 1, 2017: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/28052336/topical-ivermectin-improves-allergic-skin-inflammation
#10
Erwan Ventre, Aurore Rozières, Vanina Lenief, Floriane Albert, Patricia Rossio, Léo Laoubi, David Dombrowicz, Bart Staels, Lauriane Ulmann, Valerie Julia, Emmanuel Vial, André Jomard, Fériel Hacini-Rachinel, Jean-François Nicolas, Marc Vocanson
BACKGROUND: Ivermectin (IVM) is widely used in both human and veterinary medicine to treat parasitic infections. Recent reports have suggested that IVM could also have anti-inflammatory properties. METHODS: Here, we investigated the activity of IVM in a murine model of atopic dermatitis (AD) induced by repeated exposure to the allergen Dermatophagoides farinae, and in standard cellular immunology assays. RESULTS: Our results show that topical IVM improved allergic skin inflammation by reducing the priming and activation of allergen-specific T cells, as well as the production of inflammatory cytokines...
January 4, 2017: Allergy
https://www.readbyqxmd.com/read/28049206/novel-mechanisms-underlying-the-therapeutic-effect-of-glycomacropeptide-on-allergy-change-in-gut-microbiota-upregulation-of-tgf-%C3%AE-and-inhibition-of-mast-cells
#11
Mariela Jiménez, Daniel Cervantes-García, Yualli Haydee Muñoz, Alejandra García, Luis Miguel Haro, Eva Salinas
BACKGROUND: The prevalence of allergic diseases is globally increasing. We have previously described that glycomacropeptide (GMP), a bioactive milk peptide, has therapeutic value in experimental models of skin hypersensitivity, anaphylaxis, and asthma, as it prevents an excessive T helper type 2 cell immune response. The aim of this study was to analyze the effect of GMP on key elements directly involved in the development or control of allergy, in order to improve the precise knowledge about its mechanism of action...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/28041661/constant-light-exposure-impairs-immune-tolerance-development-in-mice
#12
Hiromi Mizutani, Risa Tamagawa-Mineoka, Yoichi Minami, Kazuhiro Yagita, Norito Katoh
BACKGROUND: An intrinsic daily physiological rhythm called circadian rhythm has been indicated to affect the immune system and its related diseases. Immune tolerance development is closely associated with the onset of immunological disorders. However, the effect of circadian rhythm in the mechanisms of immune tolerance development has not yet been fully understood. OBJECTIVE: The purpose of this study was to investigate the effects of circadian rhythm disruption on the development of immune tolerance by the perturbation of light environment, using a mouse model of neonatally induced cutaneous tolerance...
December 23, 2016: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28027401/breast-milk-poly-unsaturated-fatty-acids-associations-with-adolescent-allergic-disease-and-lung-function
#13
Nilakshi T Waidyatillake, Rachel Stoney, Francis Thien, Caroline J Lodge, Julie A Simpson, Katrina J Allen, Michael J Abramson, Bircan Erbas, Cecile Svanes, Shyamali C Dharmage, Adrian J Lowe
BACKGROUND: It has been hypothesised that n-3 PUFA in breast-milk may assist immune and lung development. There are very limited data on possible long-term effects on allergic disease and lung function. The aim was to investigate associations of n-3 and n-6 PUFA levels in colostrum and breast milk with allergic disease and lung function at ages 12 and 18 years. METHOD: PUFAs were measured in 194 colostrum samples and in 118 three month expressed breast milk samples from mothers of children enrolled in the Melbourne Atopy Cohort (MACS) Study, a high risk birth cohort study...
December 27, 2016: Allergy
https://www.readbyqxmd.com/read/28025545/the-pathogenetic-effect-of-natural-and-bacterial-toxins-on-atopic-dermatitis
#14
REVIEW
Kyung-Duck Park, Sok Cheon Pak, Kwan-Kyu Park
Atopic dermatitis (AD) is a common allergic skin disease that is associated with chronic, recurrent eczematous and pruritic lesions at the flexural folds caused by interacting factors related to environmental and immune system changes. AD results in dry skin, and immunoglobulin E-mediated allergic reactions to foods and environmental allergens. While steroids and anti-histamines temporarily relieve the symptoms of AD, the possibility of side effects from pharmacological interventions remains. Despite intensive research, the underlying mechanisms for AD have not been clarified...
December 23, 2016: Toxins
https://www.readbyqxmd.com/read/27996284/allergic-sensitization-in-kidney-transplanted-patients-is-it-a-result-of-immunosuppressive-agents-or-sensitization-of-the-living-donor
#15
Dilek Doğruel, Aytül Noyan, Hasan Dursun, Nurcan Cengiz
BACKGROUND: Allergic sensitization has been reported increasingly in organ transplant recipients. However, the pathogenesis of this sensitization has still not been clearly understood. OBJECTIVE: The aim of this study was to evaluate allergic sensitization in kidney transplanted children and adolescents under immunosuppressive treatment. METHODS: Twenty seven kidney-transplanted subjects were studied by standardized interviews from the International Study of Asthma and Allergies in Childhood criteria, skin prick test (SPT) and measurement of specific immunoglobulin E (s-IgE)...
December 12, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27992959/allergic-sensitization-at-school-age-is-a-systemic-low-grade-inflammatory-disorder
#16
Bo Lund Chawes, Jakob Stokholm, Ann-Marie Malby Schoos, Nadia Rahman, Susanne Brix, Hans Bisgaard
BACKGROUND: Systemic low-grade inflammation has been demonstrated in a range of the frequent noncommunicable diseases (NCDs) proposing a shared mechanism, but is largely unexplored in relation to allergic sensitization. We therefore aimed to investigate the possible association with childhood allergic sensitization. METHODS: High sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α) and chemokine (C-X-C motif) ligand 8 (CXCL8) were measured in plasma at age 6mo (N=214) and 7yrs (N=277) in children from the Copenhagen Prospective Studies on Asthma in Childhood2000 (COPSAC2000 ) birth cohort...
December 19, 2016: Allergy
https://www.readbyqxmd.com/read/27984001/psoriatic-inflammation-enhances-allergic-airway-inflammation-through-il-23-stat3-signaling-in-a-murine-model
#17
Ahmed Nadeem, Naif O Al-Harbi, Mushtaq A Ansari, Mohammed M Al-Harbi, Ahmed M El-Sherbeeny, Khairy M A Zoheir, Sabry M Attia, Mohamed M Hafez, Othman A Al-Shabanah, Sheikh F Ahmad
Psoriasis is an autoimmune inflammatory skin disease characterized by activated IL-23/STAT3/Th17 axis. Recently psoriatic inflammation has been shown to be associated with asthma. However, no study has previously explored how psoriatic inflammation affects airway inflammation. Therefore, this study investigated the effect of imiquimod (IMQ)-induced psoriatic inflammation on cockroach extract (CE)-induced airway inflammation in murine models. Mice were subjected to topical and intranasal administration of IMQ and CE to develop psoriatic and airway inflammation respectively...
January 15, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/27966183/electro-acupuncture-at-acupoint-st36-ameliorates-inflammation-and-regulates-th1-th2-balance-in-delayed-type-hypersensitivity
#18
Zhigang Wang, Tao Chen, Man Long, Longyun Chen, Lei Wang, Nina Yin, Zebin Chen
Increasing evidence indicates anti-allergic and anti-inflammatory effects of electro-acupuncture (EA) therapy. However, its underlying mechanism on delayed-type hypersensitivity (DTH), a classic allergic inflammatory disease, still remains unclear. In this study, we aimed to explore the immunomodulatory mechanism of EA intervention in a mouse model of ovalbumin (OVA)-induced DTH. Mice were randomly divided into four groups: Control, OVA-DTH, DTH + EA, DTH + Sham. "Zusanli" acupoint (ST36) was used for DTH + EA, whereas a non-acupoint (localized 5 mm below the "Zusanli" acupoint) was selected for DTH + Sham...
December 13, 2016: Inflammation
https://www.readbyqxmd.com/read/27931290/hygiene-factors-associated-with-childhood-food-allergy-and-asthma
#19
Ruchi S Gupta, Anne Marie Singh, Madeline Walkner, Deanna Caruso, Paul J Bryce, Xiaobin Wang, Jacqueline A Pongracic, Bridget M Smith
BACKGROUND: Childhood food allergy and asthma rates are increasing. The hygiene hypothesis has been proposed as an explanation for the increased incidence of allergic disease. OBJECTIVE: To describe the association of childhood food allergy and asthma with hygiene factors, such as the number of siblings, antibiotic use, infection history, pet exposure, child care exposure, and maternalchild factors. METHODS: Children ages 021 years old (N = 1359) were recruited for a cross-sectional family-based study, including children with food allergy and children without food allergy, and their siblings...
November 2016: Allergy and Asthma Proceedings:
https://www.readbyqxmd.com/read/27921413/short-time-efficiency-of-rhinophototherapy-in-management-of-patients-with-allergic-rhinitis-resistant-to-medical-therapy
#20
Soheila Alyasin, Seyed Hesamedin Nabavizadeh, Hamidreza Houshmand, Hossein Esmaeilzadeh, Sina Jelodar, Reza Amin
Allergic rhinitis is one of the most common health problems with a major effect on the quality of life. We intended to treat Allergic Rhinitis (AR) in patients who are either unresponsive to antihistamines or their job requires optimal alertness that may be disturbed by antihistamine's side effects and those who do not comply with the regular use. We tried short term phototherapy and evaluated its effect on AR. As phototherapy is effective in the treatment of atopic dermatitis (AD) and the same allergens can produce both AD and AR, phototherapy is proposed as a new tool in the AR treatment...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
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