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JOURNAL ARTICLE
Marek Niedoszytko, Aleksandra Gorska, Knut Brockow, Patrizia Bonadonna, Magdalena Lange, Hanneke Kluin-Nelemans, Hanneke Oude-Elberink, Vito Sabato, Khalid Shoumariyeh, Dagmar von Bubnoff, Sabine Müller, Anja Illerhaus, Michael Doubek, Irena Angelova-Fischer, Olivier Hermine, Michel Arock, Chiara Elena, Luca Malcovati, Akif Selim Yavuz, Tanja Daniela Schug, Anna Belloni Fortina, Várkonyi Judit, Jason Gotlib, Jens Panse, Vladan Vucinic, Andreas Reiter, Juliana Schwaab, Massimo Triggiani, Mattias Mattsson, Christine Breynaert, Jan Romantowski, Roberta Zanotti, Elisa Olivieri, Alexander Zink, Annick van de Ven, Alex Stefan, Stephane Barete, Francesca Caroppo, Cecelia Perkins, Vanessa Kennedy, Deborah Christen, Mohamad Jawhar, Johannes Luebke, Roberta Parente, Kerstin Levedahl, Emir Hadzijusufovic, Karin Hartmann, Boguslaw Nedoszytko, Wolfgang R Sperr, Peter Valent
BACKGROUND: Hypersensitivity reactions (HR) are common in mastocytosis. However, little is known about triggers and risk factors. The registry of the European Competence Network on Mastocytosis (ECNM) enables reliable studies in a larger cohort of mastocytosis patients. We assessed prevalence, triggers and risk factors of HR in adults with mastocytosis in the ECNM registry. METHODS: Data were collected in 27 ECNM centers. We analyzed potential triggers (Hymenoptera venoms, food, drug, inhalant and others) and risk factors at diagnosis and during follow-up...
April 23, 2024: Allergy
#2
JOURNAL ARTICLE
Sara Lamei Javan, Arman Beyraghdar Kashkooli, AbdolAli Shojaeiyan, Sina Majidian
Medicinal plants are rich sources for treating various diseases due their bioactive secondary metabolites. Fenugreek (Trigonella foenum-graecum) is one of the medicinal plants traditionally used in human nutrition and medicine which contains an active substance, called diosgenin, with anticancer properties. Biosynthesis of this important anticancer compound in fenugreek can be enhanced using eliciting agents which involves in manipulation of metabolite and biochemical pathways stimulating defense responses...
April 22, 2024: BMC Genomics
#3
JOURNAL ARTICLE
Jorge H Santoyo-Garcia, Marissa Valdivia-Cabrera, Marisol Ochoa-Villarreal, Samuel Casasola-Zamora, Magdalena Ripoll, Ainoa Escrich, Elisabeth Moyano, Lorena Betancor, Karen J Halliday, Gary J Loake, Leonardo Rios-Solis
In this study, several approaches were tested to optimise the production and recovery of the widely used anticancer drug Taxol® (paclitaxel) from culturable vascular stem cells (VSCs) of Taxus baccata, which is currently used as a successful cell line for paclitaxel production. An in situ product recovery (ISPR) technique was employed, which involved combining three commercial macro-porous resin beads (HP-20, XAD7HP and HP-2MG) with batch and semi-continuous cultivations of the T. baccata VSCs after adding methyl jasmonate (Me-JA) as an elicitor...
September 29, 2023: Bioresources and Bioprocessing
#4
JOURNAL ARTICLE
Tarun Halder, Biswajit Ghosh
Withania somnifera (L.) Dunal is an important indigenous medicinal plant with extensive pharmaceutical potential. The root is the main source of major bioactive compounds of this plant species including withanolides, withanine, phenolic acids, etc. Hairy root culture (HRC) is a crucial method for low-cost production of active compounds on a large scale. Four different Agrobacterium rhizogenes strains have been used for the hairy root induction. Maximum transformation efficiency (87.34 ± 2.13%) was achieved with A4 bacterial strain-mediated transformed culture...
April 16, 2024: Journal of Biotechnology
#5
REVIEW
Zahra Aghaali, Mohammad Reza Naghavi, Meisam Zargar
Benzylisoquinoline alkaloids (BIAs) produced in opium poppy have been evidenced to heal patients suffering from various diseases. They, therefore, hold an integral position in the herbal drug industry. Despite the adoption of several approaches for the large-scale production of BIAs, opium poppy remains the only platform in this purpose. The only disadvantage associated with producing BIAs in the plant is their small quantity. Thus, recruiting strategies that boost their levels is deemed necessary. All the methods which have been employed so far are just able to enhance a maximum of two BIAs...
2024: Frontiers in Plant Science
#6
JOURNAL ARTICLE
Charlotte Edgar, Faye Chan, Thomas Armstrong, Edwin S Dalmaijer
Countless workers handle bodily effluvia and body envelope violations every working day, and consequentially face deeply unpleasant levels of disgust. Understanding if and how they adapt can help inform policies to improve worker satisfaction and reduce staff turnover. So far, limited evidence exist that self-reported disgust is reduced (or lower to begin with) among those employed in high-disgust environments. However, it is unclear if this is due to demand effects or translates into real behavioural changes...
2024: PloS One
#7
REVIEW
Pulukkunadu Thekkeveedu Roshni, Punchappady Devasya Rekha
Coleus forskohlii , an Indian-origin medicinal plant is the sole natural source of the labdane terpenoid forskolin (C22 H34 O7 ), with growing demand . Forskolin emerged as an industrially important bioactive compound, with many therapeutic applications in human health. It has established potential effects in the treatment of various diseases and conditions such as glaucoma, asthma, obesity, allergies, skin conditions and cardiovascular diseases. Moreover, clinical trials against different types of cancers are progressing...
February 2024: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
#8
JOURNAL ARTICLE
Giulia Scimone, Maria Giovanna Carucci, Samuele Risoli, Claudia Pisuttu, Lorenzo Cotrozzi, Giacomo Lorenzini, Cristina Nali, Elisa Pellegrini, Maike Petersen
Plants are constantly subjected to environmental changes that deeply affect their metabolism, leading to the inhibition or synthesis of "specialized" compounds, small organic molecules that play a fundamental role in adaptative responses. In this work, Melissa officinalis L. (an aromatic plant broadly cultivated due to the large amounts of secondary metabolites) plants were exposed to realistic ozone (O3 ) dosages (80 ppb, 5 h day-1 ) for 35 consecutive days with the aim to evaluate its potential use as elicitor of specialized metabolite production...
March 23, 2024: Plants (Basel, Switzerland)
#9
REVIEW
Xinyi Ma, Zhiyong Yin, Haiyin Li, Jianjun Guo
The intricate relationship between herbivorous insects and plants has evolved over millions of years, central to this dynamic interaction are salivary proteins (SPs), which mediate key processes ranging from nutrient acquisition to plant defense manipulation. SPs, sourced from salivary glands, intestinal regurgitation or acquired through horizontal gene transfer, exhibit remarkable functional versatility, influencing insect development, behavior, and adhesion mechanisms. Moreover, SPs play pivotal roles in modulating plant defenses, to induce or inhibit plant defenses as elicitors or effectors...
April 15, 2024: Heliyon
#10
JOURNAL ARTICLE
María Emilia Cano, Åsa Lindgren, Jennifer Rosendahl, Jenny Johansson, Alberto Garcia-Martin, Miguel Ladero Galan, José Kovensky, Gary Chinga-Carrasco
Biomass-derived oligo- and polysaccharides may act as elicitors, i.e., bioactive molecules that trigger plant immune responses. This is particularly important to increase the resistance of plants to abiotic and biotic stresses. In this study, cellulose nanofibrils (CNF) gels were obtained by TEMPO-mediated oxidation of unbleached and bleached kraft pulps. The molecular structures were characterized with ESI and MALDI MS. Analysis of the fine sequences was achieved by MS and MS/MS of the water-soluble oligosaccharides obtained by acid hydrolysis of the CNF gels...
April 8, 2024: International Journal of Biological Macromolecules
#11
JOURNAL ARTICLE
Julie Holst Gudichsen, Emil Aggerholm Bækdal, Frederik Bloch Jessen, Annmarie Touborg Lassen, Carsten Bindslev-Jensen, Charlotte G Mortz, Søren Mikkelsen
Anaphylaxis is an allergic manifestation characterised by rapid onset and progression. Rapid treatment may be challenging in patients with atypical symptoms or no previous history of anaphylaxis. This study aimed to describe the clinical prehospital presentation of first-time anaphylactic patients. To help target educational initiatives, we sought to identify which groups of medical professionals are most likely to encounter first-time anaphylactic patients and investigated the referral pattern for suspected anaphylactic patients for specialised treatment...
April 10, 2024: Internal and Emergency Medicine
#12
JOURNAL ARTICLE
Xian Zhang, Pai Li, Yin Tang, Yu-Pei Mu, Jie Liu, Mu-Yang Wang, Wei Wang, Ying-Bo Mao
BACKGROUND: The fall armyworm (FAW, Spodoptera frugiperda (J.E. Smith)) is a polyphagous agricultural pest with rapidly evolving adaptations to host plants. We found the oral secretion (OS) of FAW from different plants influences plant defense response differentially, suggesting its role in adapting to host plants. However, the protein expression profile of FAW OS respond to different plants is largely unknown. RESULTS: Here, from the mass spectrometry assay, we identified a total of 256 proteins in the OS of FAW fed on cotton (Gossypium hirsutum L...
April 8, 2024: Pest Management Science
#13
REVIEW
Qi Wang, Xiaoyan Cang, Haiqiao Yan, Zilu Zhang, Wei Li, Jinyu He, Meixiang Zhang, Laiqing Lou, Ran Wang, Ming Chang
Calcium ion (Ca2+ ) serves as a versatile and conserved second messenger in orchestrating immune responses. In plants, plasma membrane-localized Ca2+ -permeable channels can be activated to induce Ca2+ influx from extracellular space to cytosol upon pathogen infection. Notably, different immune elicitors can induce dynamic Ca2+ signatures in the cytosol. During pattern-triggered immunity, there is a rapid and transient increase in cytosolic Ca2+ , whereas in effector-triggered immunity, the elevation of cytosolic Ca2+ is strong and sustained...
April 8, 2024: New Phytologist
#14
JOURNAL ARTICLE
Yangyang Luo, Linxia Wang, Jie Zhu, Jingwen Tian, Lin You, Qin Luo, Jia Li, Qian Yao, Dong Duan
Grapevine (Vitis vinifera L.) is an economically important fruit crop cultivated worldwide. In China, grapevine cultivation is very extensive, and a few Vitis grapes have excellent pathogen and stress resistance, but the molecular mechanisms underlying the grapevine response to stress remain unclear. In this study, a microRNA (miRNA; miR827a), which negatively regulates its target gene VqMYB14, a key regulatory role in the synthesis of stilbenes, was identified in Vitis quinquangularis (V. quinquangularis) using transcriptome sequencing...
April 6, 2024: TAG. Theoretical and Applied Genetics. Theoretische und Angewandte Genetik
#15
JOURNAL ARTICLE
Maryam Abedini, Alireza Iranbakhsh, Sara Saadatmand, Mostafa Ebadi, Zahra Oraghi Ardebili
The effect of low artificial Ultraviolet (UV) on the DNA methylation remains controversial. This study addresses how differential photoperiods of UV radiation affect the biochemical and molecular behaviors of Cannabis indica cell suspension cultures. The cell suspensions were illuminated with the compact fluorescent lamps (CFL), emitting a combination of 10% UVB, 30% UVA, and the rest visible wavelengths for 0, 4, 8, and 16 h. The applied photoperiods influenced cell morphological characteristics. The 4 h photoperiod was the most effective treatment for improving biomass, growth index and cell viability percentage while these indices remained non-significant in the 16 h treatment...
March 29, 2024: Journal of Photochemistry and Photobiology. B, Biology
#16
JOURNAL ARTICLE
Fujie Liu, Sheng Cai, Lingjun Dai, Nijiang Ai, Guoli Feng, Ningshan Wang, Wenli Zhang, Kang Liu, Baoliang Zhou
Alternative splicing (AS) of pre-mRNAs increases the diversity of transcriptome and proteome and plays fundamental roles in plant development and stress responses. However, the prevalent changes in AS events and the regulating mechanisms of plants in response to pathogens remain largely unknown. Here, we show that AS changes are an important mechanism conferring cotton immunity to Verticillium dahliae (Vd). GauSR45a, encoding a serine/arginine-rich RNA binding protein, was upregulated expression and underwent AS in response to Vd infection in Gossypium australe, a wild diploid cotton species highly resistant to Vd...
April 3, 2024: Plant Journal
#17
JOURNAL ARTICLE
Kelly V Evans, Elspeth Ransom, Swapna Nayakoti, Ben Wilding, Faezah Mohd Salleh, Irena Gržina, Lieselotte Erber, Carmen Tse, Claire Hill, Krzysztof Polanski, Alistair Holland, Sherien Bukhat, Robert J Herbert, Barend H J de Graaf, Katherine Denby, Vicky Buchanan-Wollaston, Hilary J Rogers
SAG21/LEA5 is an unusual late embryogenesis abundant protein in Arabidopsis thaliana, that is primarily mitochondrially located and may be important in regulating translation in both chloroplasts and mitochondria. SAG21 expression is regulated by a plethora of abiotic and biotic stresses and plant growth regulators indicating a complex regulatory network. To identify key transcription factors regulating SAG21 expression, yeast-1-hybrid screens were used to identify transcription factors that bind the 1685 bp upstream of the SAG21 translational start site...
April 2, 2024: Scientific Reports
#18
JOURNAL ARTICLE
Carmen Formisano, Nunzio Fiorentino, Ida Di Mola, Nunzia Iaccarino, Ernesto Gargiulo, Giuseppina Chianese
Phytocannabinoids represent the hallmark of the secondary metabolism of Cannabis sativa . The content of major phytocannabinoids is closely related to genetic variation as well as abiotic elicitors such as temperature, drought, and saline stress. The present study aims to evaluate hemp response to saline irrigation supplied as NaCl solutions with an electrical conductivity (EC) of 2.0, 4.0, and 6.0 dS m-1 (S1, S2, and S3, respectively) compared to a tap water control (S0). In addition, the potential beneficial effect of a plant-based biostimulant (a legume protein hydrolysate) in mitigating the detrimental effects of saline irrigation on crop growth and phytocannabinoid composition was investigated...
2024: Frontiers in Plant Science
#19
JOURNAL ARTICLE
Michiel Beyens, Vito Sabato, Didier G Ebo, Taleb Zaghmout, Theo Gülen
BACKGROUND: Anaphylaxis is a common feature of mastocytosis patients, particularly with Hymenoptera venoms. Hence, it is hypothesized that mastocytosis patients may have an increased susceptibility to developing drug-induced anaphylaxis (DIA). Patients and medical practitioners are therefore concerned when there is a need to use various drugs. However, this issue has not been systematically investigated. OBJECTIVE: Our study aimed to investigate the prevalence and clinical characteristics of anaphylaxis to various types of drugs among mastocytosis patients...
March 29, 2024: Journal of Allergy and Clinical Immunology in Practice
#20
BioMed Research International
[This retracts the article DOI: 10.1155/2022/3097521.].
2024: BioMed Research International
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