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Systemic aquired resistance

Willem van Schaik, Janetta Top, David R Riley, Jos Boekhorst, Joyce E P Vrijenhoek, Claudia M E Schapendonk, Antoni P A Hendrickx, Isaäc J Nijman, Marc J M Bonten, Hervé Tettelin, Rob J L Willems
BACKGROUND: The Gram-positive bacterium Enterococcus faecium is an important cause of nosocomial infections in immunocompromized patients. RESULTS: We present a pyrosequencing-based comparative genome analysis of seven E. faecium strains that were isolated from various sources. In the genomes of clinical isolates several antibiotic resistance genes were identified, including the vanA transposon that confers resistance to vancomycin in two strains. A functional comparison between E...
2010: BMC Genomics
Bernd Koppold, Georg Sauer, Hildegard Büning, Michael Hallek, Rolf Kreienberg, Helmut Deissler, Christian Kurzeder
Recombinant adeno-associated virus type 2 (rAAV) has many properties of an ideal vector for gene therapy: broad spectrum of susceptible cells, efficient gene transfer, persistent transgene expression in vivo, and no indiction of vector-related toxicity. Ovarian carcinoma cell lines, however, were previously reported to be quite resistant to rAAV transduction. Using an optimized adenovirus-free packaging system, highly purified rAAV vectors coding for the enhanced green fluorescent protein (AAV/EGFP) and for mCD40 ligand (AAV/CD40L) were generated...
January 2005: International Journal of Oncology
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