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PSA kinetics

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https://www.readbyqxmd.com/read/28639017/removal-of-polyvinylamine-sulfonate-anthrapyridone-dye-by-application-of-heterogeneous-electro-fenton-process
#1
Bakhta Bouzayani, Jessica Meijide, Marta Pazos, Sourour Chaâbane Elaoud, Maria Angeles Sanroman
Diversity and rapidly multiplication of the pollutants incite as to improve the conventional treatments wastewater methods. One of the bottlenecks often faced is the presence into wastewater of organic pollutants with complex structures that requests the design of efficient processes. Thus, this work investigates the removal of polyvinylamine sulfonate anthrapyridone (PSA) dye which complex structure makes difficult its degradation by conventional technologies. For that, a heterogeneous oxidative process using pyrite as sustainable catalyst was designed...
June 21, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28635569/stratification-model-based-on-early-postprostatectomy-prostate-specific-antigen-kinetics-may-help-to-reduce-the-risk-of-overtreatment-in-candidates-for-adjuvant-radiotherapy
#2
Stepan Vesely, Ladislav Jarolim, Marek Schmidt, Joana Do Carmo Silva, Katerina Duskova, Marko Babjuk
OBJECTIVE: The aim of this study was to construct a stratification model based on early postoperative kinetics of prostate-specific antigen (PSA) to select the most suitable high-risk patients for early intervention after radical prostatectomy (RP). MATERIALS AND METHODS: The study evaluated 205 men who had undergone RP without any adjuvant treatment. All of the patients had positive surgical margins, extracapsular extension and/or seminal vesicle invasion. The patients underwent multiple ultrasensitive PSA measurements on days 14, 30, 60 and 90 after RP, and subsequently at 3 month intervals...
February 24, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28624638/the-fate-of-spirotetramat-and-dissipation-metabolites-in-apiaceae-and-brassicaceae-leaf-root-and-soil-system-under-greenhouse-conditions-estimated-by-modified-quechers-lc-ms-ms
#3
Bożena Łozowicka, Patrycja Mojsak, Piotr Kaczyński, Rafał Konecki, Andrzej Borusiewicz
The aim of this study was to investigate the dissipation of spirotetramat and its four metabolites (B-enol, B-keto, B-mono and B-glu) in different parts of vegetables belong to the minor crops (Appiacea and Brassicaceae) and soil from cultivation. The challenge of this study was to apply an optimized clean up step in QuEChERS to obtain one universal sorbent for different complex matrices like leaves with high levels of pigments, roots containing acids, sugars, polyphenolls and pigments and soil with organic ingredients...
June 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28586946/increasing-fractional-doses-increases-the-probability-of-benign-psa-bounce-in-patients-undergoing-definitive-hdr-brachytherapy-for-prostate-cancer
#4
Carlin R Hauck, Hong Ye, Peter Y Chen, Gary S Gustafson, Amy Limbacher, Daniel J Krauss
PURPOSE: Prostate-specific antigen (PSA) bounce is a temporary elevation of the PSA level above a prior nadir. The purpose of this study was to determine whether the frequency of a PSA bounce following high-dose-rate (HDR) interstitial brachytherapy for the treatment of prostate cancer is associated with individual treatment fraction size. METHODS AND MATERIALS: Between 1999 and 2014, 554 patients underwent treatment of low- or intermediate-risk prostate cancer with definitive HDR brachytherapy as monotherapy and had ≥3 subsequent PSA measurements...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28558685/predictors-of-survival-outcomes-in-native-sub-saharan-black-men-newly-diagnosed-with-metastatic-prostate-cancer
#5
Jibril Oyekunle Bello
BACKGROUND: Though it is well established that black men are at higher risk of prostate cancer (PCa) very little is known about the disease in native sub Saharan black men. Newly diagnosed metastatic PCa patients treated with primary androgen deprivation therapy were identified and predictors of progression-free survival (PFS) assessed. METHODS: Patients diagnosed with metastatic PCa between 2010 and 2015 in a sub Saharan black population were included in the study...
May 30, 2017: BMC Urology
https://www.readbyqxmd.com/read/28442907/synthesis-of-magnetic-molecularly-imprinted-polymers-with-excellent-biocompatibility-for-the-selective-separation-and-inhibition-of-testosterone-in-prostate-cancer-cells
#6
Xiaoshuang Tang, Feng Li, Jing Jia, Chao Yang, Wei Liu, Ben Jin, Xinyang Wang, Ruixia Gao, Dalin He, Peng Guo
PURPOSE: Androgen plays an important role in the progression of prostate cancer. In the present study, novel magnetic molecularly imprinted polymers (MMIPs) with good biocompatibility were produced for the selective separation and inhibition of testosterone in prostate cancer cells. MATERIALS AND METHODS: MMIPs were prepared by using magnetic nanospheres, gelatin, and testosterone as the supporting materials, functional monomer, and the template molecule, respectively...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28430341/prostate-specific-antigen-increase-during-dutasteride-to-indicate-the-need-for-prostate-biopsy-influence-of-prostatic-inflammation
#7
Alessandro Sciarra, Martina Maggi, Andrea Fasulo, Stefano Salciccia, Vincenzo Gentile, Susanna Cattarino, Alessandro Gentilucci
INTRODUCTION: The aim of this study was to analyze the significance of an increase in total prostate-specific antigen (PSA) serum levels despite dutasteride treatment as a predictor of prostate cancer (PC) at biopsy. We focused our attention on the rate of the first PSA increase and on the influence of prostatic inflammation. METHODS: From 2011 to 2016, 365 men with a previous negative prostate biopsy and persistent elevated PSA levels received dutasteride treatment...
April 4, 2017: Urologia
https://www.readbyqxmd.com/read/28410987/alkaline-phosphatase-velocity-predicts-overall-survival-and-bone-metastasis-in-patients-with-castration-resistant-prostate-cancer
#8
Kai H Hammerich, Timothy F Donahue, Inger L Rosner, Jennifer Cullen, Huai-Ching Kuo, Lauren Hurwitz, Yongmei Chen, Melanie Bernstein, Jonathan Coleman, Daniel C Danila, Adam R Metwalli
INTRODUCTION AND OBJECTIVES: Identifying patients with prostate cancer (CaP) who will ultimately develop bone metastasis (BM) or die of disease is essential. Alkaline phosphatase velocity (APV) has been shown to predict overall survival (OS) and bone metastasis-free survival (BMFS) in an earlier study of an equal access military patient cohort of patients with castrate-resistant prostate cancer (CRPC). To confirm these findings, we examined a cohort of patients from a high-volume cancer center to validate a previous observation that faster alkaline phosphatase (AP) kinetics are predictive of OS and BMFS in this second cohort of patients...
April 11, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28389027/role-of-pet-ct-with-18-f-fluorocholine-in-biochemical-recurrence-after-treatment-of-prostate-cancer-with-curative-intent
#9
I Puche-Sanz, E Triviño-Ibáñez, F Vázquez-Alonso, J M Llamas-Elvira, J M Cózar-Olmo, A Rodríguez-Fernández
OBJECTIVES: To analyse the ability of the PET-CT with (18)F-fluorocholine ((18)F-FCH) to detect disease on biochemical recurrence after treatment with curative intent. To determine the clinical variables that would be able to optimise the test's diagnostic yield. MATERIAL AND METHODS: A retrospective study of PET-CTs with (18)F-fluorocholine performed on 61 patients with prostate cancer who had undergone treatment with curative intent and met the criteria for biochemical recurrence...
April 4, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/28372248/validation-of-quechers-based-method-for-determination-of-fenitrothion-residues-in-tomatoes-by-gas-chromatography-flame-photometric-detector-decline-pattern-and-risk-assessment
#10
Farag Malhat, Julien Boulangé, Ehab Abdelraheem, Osama Abd Allah, Rania Abd El-Hamid, Shokr Abd El-Salam
A simple and rapid gas chromatography with flame photometric detector (GC-FPD) determination method was developed to detect residue levels and investigate the dissipation pattern and safe use of fenitrothion in tomatoes. A modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) using an ethyl acetate-based extraction, followed by a dispersive solid-phase extraction (d-SPE) with primary-secondary amine (PSA) and graphite carbon black (GCB) for clean up, was applied prior to GC-FPD analysis. The method showed satisfactory linearity, recovery and precision...
August 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28357712/determination-of-relative-counterion-binding-constant-to-cationic-micelles
#11
REVIEW
Khalisanni Khalid, Muhammad Azri Mohd Noh, Sharifuddin Md Zain, M Niyaz Khan
The efficiency of counterion affinity towards ionic micelles is often described in terms of the degree of counterion binding (β X ) to ionic micelles or the conventional ion-exchange constant ([Formula: see text]) or relative binding constant ([Formula: see text]) of X (-) and Br(-) counterions. This review describes the use of ionized phenyl salicylate ions, PSa(-), as a new probe to determine [Formula: see text] values using a semiempirical spectrophotometric method. The value of [Formula: see text] is found to be comparable to reported values obtained using different probes by the semiempirical kinetic method as well as different physical methods...
April 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/28320288/analysis-of-photoprotection-and-apparent-non-photochemical-quenching-of-chlorophyll-fluorescence-in-tradescantia-leaves-based-on-the-rate-of-irradiance-induced-changes-in-optical-transparence
#12
V V Ptushenko, O S Ptushenko, O P Samoilova, A E Solovchenko
The kinetics of irradiation-induced changes in leaf optical transparence (ΔT) and non-photochemical quenching (NPQ) of chlorophyll fluorescence in Tradescantia fluminensis and T. sillamontana leaves adapted to different irradiance in nature was analyzed. Characteristic times of a photoinduced increase and a dark decline of ΔT in these species were 12 and 20 min, respectively. The ΔT was not confirmed to be the main contributor to the observed middle phase of NPQ relaxation kinetics (τ = 10-28 min). Comparison of rate of photoinduced increase in ΔT and photosystem II quantum yield recovery showed that the former did not affect the tolerance of the photosynthetic apparatus (PSA) to irradiances up to 150 µmol PAR·m(-2)·s(-1)...
January 2017: Biochemistry. Biokhimii︠a︡
https://www.readbyqxmd.com/read/28283654/a-model-based-personalized-cancer-screening-strategy-for-detecting-early-stage-tumors-using-blood-borne-biomarkers
#13
Sharon Seiko Hori, Amelie M Lutz, Ramasamy Paulmurugan, Sanjiv S Gambhir
An effective cancer blood biomarker screening strategy must distinguish aggressive from non-aggressive tumors at an early, intervenable time. However, for blood-based strategies to be useful, the quality and quantiy of the biomarker shed into the blood and its relationship to tumor growth or progression must be validated. To study how blood biomarker levels correlate with early-stage viable tumor growth in an mouse model of human cancer, we monitored early tumor growth of engineered human ovarian cancer cells (A2780) implanted orthotopically into nude mice...
March 10, 2017: Cancer Research
https://www.readbyqxmd.com/read/28274741/a-systemic-evaluation-of-drug-in-acrylic-pressure-sensitive-adhesive-patch-in-vitro-and-in-vivo-the-roles-of-intermolecular-interaction-and-adhesive-mobility-variation-in-drug-controlled-release
#14
Chao Liu, Peng Quan, Shanshan Li, Yongshan Zhao, Liang Fang
Though acrylic pressure sensitive adhesives (PSAs) are widely used in transdermal drug delivery system, molecular details of drug-PSA interactions, PSA molecular mobility variations and their influences on drug skin permeation are unclear. In this study, three classes of acrylic PSAs containing hydroxyl (AAOH), carboxyl (AACOOH) and non-functional group (AAnone) were synthesized. Their abilities of controlling drug release were evaluated using propranolol (PRO) and zaltoprofen (ZAL) in vitro and in vivo. Interaction details were identified by FT-IR, solid-state NMR and molecular modeling...
March 6, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28267448/imaging-of-prostate-cancer-using-11-c-choline-pet-computed-tomography
#15
REVIEW
Paolo Castellucci, Francesco Ceci, Stefano Fanti
This article reviews the role of (11)C-choline-PET/computed tomography (CT) in patients with prostate cancer for diagnosis, staging, and restaging the disease in case of biochemical recurrence after primary treatment. The main application of this imaging procedure is restaging of the disease in case of biochemical recurrence. (11)C-Choline-PET/CT proved its value for metastases-directed salvage therapies and for monitoring therapy response in castration-resistant patients. Prostate-specific antigen and prostate-specific antigen kinetics values confirmed their correlation with (11)C-choline PET/CT sensitivity...
April 2017: PET Clinics
https://www.readbyqxmd.com/read/28176042/acclimation-of-shade-tolerant-and-light-resistant-tradescantia-species-to-growth-light-chlorophyll-a-fluorescence-electron-transport-and-xanthophyll-content
#16
Vladimir I Mishanin, Boris V Trubitsin, Svetlana V Patsaeva, Vasily V Ptushenko, Alexei E Solovchenko, Alexander N Tikhonov
In this study, we have compared the photosynthetic characteristics of two contrasting species of Tradescantia plants, T. fluminensis (shade-tolerant species), and T. sillamontana (light-resistant species), grown under the low light (LL, 50-125 µmol photons m(-2) s(-1)) or high light (HL, 875-1000 µmol photons m(-2) s(-1)) conditions during their entire growth period. For monitoring the functional state of photosynthetic apparatus (PSA), we measured chlorophyll (Chl) a emission fluorescence spectra and kinetics of light-induced changes in the heights of fluorescence peaks at 685 and 740 nm (F 685 and F 740)...
February 8, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28123863/performance-characteristics-and-relationship-of-psa-value-kinetics-on-carbon-11-acetate-pet-ct-imaging-in-biochemical-relapse-of-prostate-cancer
#17
Fabio D Almeida, Chi-Kwan Yen, Mark C Scholz, Richard Y Lam, Jeffrey Turner, Larry L Bans, Robert Lipson
An elevated serum prostate-specific antigen (PSA) level alone cannot distinguish between local-regional recurrences and distant metastases after treatment with curative intent. With available salvage treatments, it has become important to localize the site of recurrence. (11)C-Acetate PET/CT was performed in patients with rising PSA, with statistical analysis of detection rates, sites/location of detection, PSA kinetics and comparison with other tracers (FDG and Choline). Correlation to biopsy, subsequent imaging and PSA response to focal treatment was also performed...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28110170/tailoring-polymeric-hybrid-micelles-with-lymph-node-targeting-ability-to-improve-the-potency-of-cancer-vaccines
#18
Qin Zeng, Hanmei Li, Hao Jiang, Jiao Yu, Ying Wang, Huan Ke, Tao Gong, Zhirong Zhang, Xun Sun
It has been widely accepted that lymph nodes (LNs) are critical targets of cancer vaccines and particles sized between 10 and 100 nm with a neutral or negative surface charge are preferred for lymphatic transfer after subcutaneous or intradermal injection. However their limited uptake by antigen presenting cells (APCs) and inadequate retention within LNs undoubtedly restrains their strength on activating T cell immunity. Here, we address this issue by tailoring the physicochemical properties of polymeric hybrid micelles (HMs), which are self-assembled from two amphiphilic diblock copolymers, poly-(ethylene glycol) phosphorethanolamine (PEG-PE) and polyethylenimine-stearic acid conjugate (PSA) via hydrophobic and electrostatic interactions...
January 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/27933964/revisiting-the-sar-of-the-antischistosomal-aryl-hydantoin-ro-13-3978
#19
Chunkai Wang, Qingjie Zhao, Mireille Vargas, Jeremy O Jones, Karen L White, David M Shackleford, Gong Chen, Jessica Saunders, Alice C F Ng, Francis C K Chiu, Yuxiang Dong, Susan A Charman, Jennifer Keiser, Jonathan L Vennerstrom
The aryl hydantoin 1 (Ro 13-3978) was identified in the early 1980s as a promising antischistosomal lead compound. However, this series of aryl hydantoins produced antiandrogenic side effects in the host, a not unexpected outcome given their close structural similarity to the antiandrogenic drug nilutamide. Building on the known SAR of this compound series, we now describe a number of analogs of 1 designed to maximize structural diversity guided by incorporation of substructures and functional groups known to diminish ligand-androgen receptor interactions...
December 8, 2016: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27881285/conventionally-fractionationed-volumetric-arc-therapy-versus-hypofractionated-stereotactic-body-radiotherapy-quality-of-life-side-effects-and-prostate-specific-antigen-kinetics-in-localized-prostate-cancer
#20
Makbule Tambas, Fulya Agaoglu, Ayca Iribas, Murat Guveli, Yavuz Dizdar, Murat Okutan, Dilek Sahin, Nuri Tenekeci, Emin Darendeliler
OBJECTIVES: To compare conventionally fractionationed volumetric arc therapy (VMAT) and hypofractionated stereotactic body radiotherapy (SBRT) modalities in terms of prostate-specific antigen (PSA) kinetics, toxicity, and quality of life (QOL) in patients with localized prostate cancer. METHODS: Patients received radical radiotherapy as either 33.5 Gy/5 fr for SBRT or 75.6 Gy/35 fr for VMAT. International Prostate Symptom Score (IPSS) and European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Prostate Cancer Module (QLQ-PR25) forms were used to assess QOL...
September 2016: Value in Health Regional Issues
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