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https://www.readbyqxmd.com/read/29453885/bacterial-neuraminidase-mediated-erythrocyte-desialylation-provokes-cell-surface-aminophospholipid-exposure
#1
Syed M Qadri, David A Donkor, Ishac Nazy, Donald R Branch, William P Sheffield
BACKGROUND: Surface desialylation is associated with erythrocyte aging and mediates phagocytic recognition and clearance of senescent erythrocytes. Neuraminidases, a family of glycohydrolytic enzymes, cleave the glycosidic linkages between sialic acid and mucopolysaccharides and have previously been implicated in erythrocyte dysfunction associated with sepsis. Erythrocytes in septic patients further display a phenotype of accelerated eryptosis characterized by membrane phospholipid scrambling resulting in phosphatidylserine (PS) externalization...
February 17, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29440963/heritage-of-stanis%C3%A5-aw-ostrowski-the-only-one-medical-doctor-who-became-state-polish-president-patriae-semper-fidelis
#2
Martyna Woltanowska, Piotr Woltanowski, Andrzej Wincewicz, Magdalena Woltanowska
Aim: Our purpose was to write a biography of Stanisław Ostrowski that would address in the first place the medical aspect of his professional life, with a comprehensive approach of others fields of his activity. Methods: We essentially grounded the paper on primary resources that were papers authored by Ostrowski including his scientific publications, memories, speeches as well as contemporaneous official documents that referred to Ostrowski. Second resources were also used to double check some data from primary resources and to place the biography of Stanisław Ostrowski in a proper background with special care to social, professional and political context...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29436796/predictive-value-of-braden-risk-factors-in-pressure-ulcers-of-outpatients-with-spinal-cord-injury
#3
Fariba Sadeghi Fazel, Nazi Derakhshanrad, Mir Saeed Yekaninejad, Fardis Vosoughi, Asal Derakhshanrad, Hooshang Saberi
Pressure Ulcers (PUs) remain among the most common complications after traumatic spinal cord Injuries (SCIs). The main goal of risk factor assessment with different tools has been to provisionally estimate the chance of developing pressure ulcers in patients with Spinal Cord Injury (SCI). Braden tool has been of good predictive value and most commonly employed in hospital communities for risk assessment of pressure sore development. The objective of this study was to determine the Braden risk factors as well as the prevalence of pressure injuries in SCI patients...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29409095/-from-the-history-of-the-german-society-of-internal-medicine-dgim-part-2-the-dgim-in-the-post-war-period
#4
Ralf Forsbach, Hans-Georg Hofer
Although times were difficult in 1947/48 - with war damage, travel restrictions and the East-West conflict - the German Society for Internal Medicine not only managed to re-organise itself but also hosted its first scientific congress in that year. The DGIM members Franz Volhard and Paul Martini, who rather disapproved of the Nazi regime, played a decisive role in this process. However, a critical discussion of the NS medical crimes, which occurred just a few years ago, remained the exception. It is interesting to note that members who were persecuted by the NS regime were nevertheless willing to attend a congress that obviously provided a forum for the protagonists of the Nazi era...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29406846/six-values-never-to-silence-jewish-perspectives-on-nazi-medical-professionalism
#5
REVIEW
Jacob M Kolman, Susan M Miller
An ideological case study based on medical profession norms during the Third Reich will be used to exemplify the importance of diversity in the manifestations of professional ethics. The German professional medical community banned their Jewish colleagues from treating German citizens. This included legally mandated employment discrimination and outright censure which led to a professional ethic devoid of diverse voices. While the escalation to the T-4 program and medicalized genocide was influenced by many causes, the intentional, ethnocentric-based exclusion of voices was an important contributing element to the chronicled degradation of societal mores...
January 29, 2018: Rambam Maimonides Medical Journal
https://www.readbyqxmd.com/read/29338560/scientists-instruments-and-even-brains-in-transfer-german-spanish-postwar-networks-and-the-construction-of-the-neuroendocrine-system-1952-1960
#6
Raúl Velasco Morgado
This article presents the process of relocation of hegemonies and "center-periphery" dynamics in neuroanatomy after World War II through the study of the links between the Spanish anatomical school of José Escolar García and some German institutions. We have analyzed their works on the morphology of the neuroendocrine system as a case study, showing how the first contacts of the Spaniards with the United States started a material transfer process between centers on both sides of the Atlantic Ocean through the mediation-and adaptation-of the periphery...
January 1, 2018: Neuroscientist: a Review Journal Bringing Neurobiology, Neurology and Psychiatry
https://www.readbyqxmd.com/read/29327654/delayed-reaction-the-tardy-embrace-of-physical-organic-chemistry-by-the-german-chemical-community
#7
Stephen J Weininger
The emergence of physical organic chemistry, which focuses on the mechanisms and structures of organic reactions and molecules using the tools of physical chemistry, was a major development in twentieth-century chemistry. It first flourished in the interwar period, in the UK and then in the US. Germany, by contrast, did not embrace the field until almost a half century later. The great success of classical organic chemistry, especially in synthesis, encouraged indifference to the new field among German chemists, as did their inductivist research philosophy, as enunciated by Walter Hückel's ground-breaking textbook (1931)...
January 12, 2018: Ambix
https://www.readbyqxmd.com/read/29325985/platelet-activating-antibodies-are-detectable-at-the-earliest-onset-of-heparin-induced-thrombocytopenia-with-implications-for-the-operating-characteristics-of-the-serotonin-release-assay
#8
Theodore E Warkentin, Donald M Arnold, John G Kelton, Jo-Ann I Sheppard, James W Smith, Ishac Nazy
BACKGROUND: HIT is a prothrombotic drug reaction caused by platelet-activating antibodies that recognize PF4/heparin complexes. It is unknown whether platelet-activating antibodies are detectable at the onset of the HIT-related platelet count fall. METHODS: Available blood samples from 18 patients obtained at onset of HIT were tested using the serotonin-release assay (SRA), a test for platelet-activating antibodies, and a PF4-dependent ELISA. Patient samples showing a delay of >2 days between ELISA and SRA seroconversion were tested for subthreshold levels of platelet-activating antibodies using two modifications of the SRA that amplify detection of HIT antibodies...
January 8, 2018: Chest
https://www.readbyqxmd.com/read/29325197/-from-the-history-of-the-german-society-of-internal-medicine-dgim-part-1-the-dgim-in-the-nazi-era
#9
Ralf Forsbach, Hans-Georg Hofer
No abstract text is available yet for this article.
January 11, 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29296891/misdiagnosis-of-primary-immune-thrombocytopenia-and-frequency-of-bleeding-lessons-from-the-mcmaster-itp-registry
#10
Donald M Arnold, Ishac Nazy, Rumi Clare, Anushka M Jaffer, Brandon Aubie, Na Li, John G Kelton
Nonspecific diagnostic criteria and uncertain estimates of severe bleeding events are fundamental gaps in knowledge of primary immune thrombocytopenia (ITP). To address these issues, we created the McMaster ITP Registry. In this report, we describe the methodology of the registry, the process for arriving at the diagnosis, and the frequency of bleeding. Consecutive patients with platelets <150 × 109/L from a tertiary hematology clinic in Canada were eligible. Patients completed a panel of investigations and were managed per clinical need...
November 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29276992/a-review-of-epidemiologic-studies-on-suicide-before-during-and-after-the-holocaust
#11
REVIEW
Itzhak Levav, Anat Brunstein Klomek
The available literature on the risk of suicides related to the Holocaust (1939-1945) and its aftermath differs in its time periods, in the countries investigated, and in the robustness of its sources. Reliable information seems to indicate that the risk of suicide for Jews in Nazi Germany and Austria during the pre-war period (1933-1939) was elevated, while information on suicide during the internment in the concentration camps is fraught with problems. The latter derives from the Nazis' decision to hide the statistics on the inmates' causes of death, and from the prevailing life conditions that impeded separation between self-inflicted death and murder...
December 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29248900/karl-jaspers-the-icon-of-modern-psychiatry
#12
Michael A Schwartz, Marcin Moskalewicz, Osborne P Wiggins
December 2015 and March 2016 issues of the American Journal of Psychiatry contain a debate focusing on the legacy of Emil Kraepelin, widely considered one of the founders if not the iconic founder of modern scientific psychiatry. The authors, Eric J. Engstrom and Kenneth S. Kendler, challenge the so-called neo-Kraepelinian view of Kraepelin and argue that the true, historical Kraepelin was far more inclined towards scientific psychology, less reductionist and brain-centric, and more skeptical nosologically than his later followers apparently believe...
2017: Israel Journal of Psychiatry and related Sciences
https://www.readbyqxmd.com/read/29241240/clinical-practice-informs-secure-messaging-benefits-and-best-practices
#13
Jolie N Haun, Wendy Hathaway, Margeaux Chavez, Nicole Antinori, Brian Vetter, Brian K Miller, Tracey L Martin, Lisa Kendziora, Kim M Nazi, Christine Melillo
Background Clinical care team members in Department of Veterans' Affairs (VA) facilities nationwide are working to integrate the use of Secure Messaging (SM) into care delivery and identify innovative uses. Identifying best practices for proactive use of SM is a key factor in its successful implementation and sustained use by VA clinical care team members and veterans. Objectives A collaborative project solicited input from VA clinical care teams about their local practices using SM to provide access to proactive patient-centered care for veterans and enhance workflow...
October 2017: Applied Clinical Informatics
https://www.readbyqxmd.com/read/29207433/-from-the-history-of-the-german-society-of-internal-medicine-dgim-part-1-the-dgim-in-the-nazi-era
#14
Ralf Forsbach, Hans-Georg Hofer
51 years after its founding in 1882, the "Congress for Internal Medicine", 1920 renamed "German Society for Internal Medicine (DGIM)", fell into heavy water. While during the Kaiserreich and the Weimar Republic the medical care for the individual patient had never been seriously questioned, the proclaimed "Third Reich" brought fundamental changes. The 1164 male and 13 female physicians, who had been organized in the DGIM 1933, had to position themselves in the Nazi dictatorship. The same applied for the society as a whole...
December 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29172900/development-of-a-high-yield-expression-and-purification-system-for-platelet-factor-4
#15
Angela Huynh, Donald M Arnold, Jane C Moore, James W Smith, John G Kelton, Ishac Nazy
Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction characterized by IgG antibodies bound to complexes of platelet factor 4 (PF4) and heparin. The majority of diagnostic tests for HIT rely on an exogenous source of PF4 to identify anti-PF4/heparin antibodies. These include the PF4-dependent enhanced serotonin release assay (PF4-SRA) among others. Using a bacterial expression system, we developed a novel and efficient method of producing recombinant human PF4 (rhPF4) that is biochemically and antigenically similar to platelet-derived human PF4...
November 27, 2017: Platelets
https://www.readbyqxmd.com/read/29161068/the-nazi-physicians-as-leaders-in-eugenics-and-euthanasia-lessons-for-today
#16
Michael A Grodin, Erin L Miller, Johnathan I Kelly
This article, in commemoration of the 70th anniversary of the Doctors' Trial at Nuremberg, reflects on the Nazi eugenics and "euthanasia" programs and their relevance for today. The Nazi doctors used eugenic ideals to justify sterilizations, child and adult "euthanasia," and, ultimately, genocide. Contemporary euthanasia has experienced a progression from voluntary to nonvoluntary and from passive to active killing. Modern eugenics has included both positive and negative selective activities. The 70th anniversary of the Doctors' Trial at Nuremberg provides an important opportunity to reflect on the implications of the Nazi eugenics and "euthanasia" programs for contemporary health law, bioethics, and human rights...
January 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29161065/from-nuremberg-to-guantanamo-bay-uses-of-physicians-in-the-war-on-terror
#17
Sondra S Crosby, Gilbert Benavidez
Seventy years after the Nuremberg Doctors' Trial, health professionals and lawyers working together after 9/11 played a critical role in designing, justifying, and carrying out the US state-sponsored torture program in the CIA "Black Sites" and US military detention centers, including Abu Ghraib, Bagram, and Guantanamo Bay, Cuba. We analyze the similarities between the Nazi doctors and health professionals in the War on Terror and address the question of how it happened that health professionals, including doctors, psychologists, physician assistants, and nurses, acted as agents of the state to utilize their medical and healing skills to cause harm and sanitize barbarous acts, similar to (though not on the scale of) how Nazi doctors were used by the Third Reich...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161060/beyond-nazi-war-crimes-experiments-the-voluntary-consent-requirement-of-the-nuremberg-code-at-70
#18
George J Annas
The year 2017 marks both the 70th anniversary of the Nuremberg Code and the first major revisions of federal research regulations in almost 3 decades. I suggest that the informed consent provisions of the federal research regulations continue to follow the requirements of the Nuremberg Code. However, modifications are needed to the informed consent (and institutional review board) provisions to make the revised federal regulations more effective in promoting a genuine conversation between the researcher and the research subject...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29161059/american-doctors-at-the-nuremberg-medical-trial
#19
Evelyne Shuster
Three Hippocratic physicians played critical roles in the prosecution of 23 Nazi doctors charged with murder and torture for conducting lethal medical experiments on concentration camp prisoners. Two of the physicians, Leopold Alexander and Andrew C. Ivy, were Americans, and the other, Werner Leibbrandt, was German. At the 70th anniversary of the Doctors' Trial it is fitting to recall the three's influences and contributions to the formulation of strict research ethics rules, known as the Nuremberg Code. Their contributions help us better understand why they insisted on strict research rules and yet ultimately were unable to apply these rules to their own research...
November 21, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/29159768/the-impact-of-dealing-with-the-late-effects-of-national-socialist-terror-on-west-german-psychiatric-care
#20
Felicitas Söhner, Gerhard Baader
Health damages and the late effects of NS trauma were largely ignored in German-speaking countries. This paper describes how dealing with the late effects of Nazi terror influenced post-war psychiatry in West Germany and thus the development of the psychiatric reform. As part of a greater overview study of the impulses and framework conditions of the reform-orientated development of post-war psychiatry in West Germany, this analysis is based on a thorough literary and documentary analysis. The sources show that publications by Helmut Paul and Herberg [81] as well as Baeyer et al...
November 21, 2017: Psychiatric Quarterly
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