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https://www.readbyqxmd.com/read/28444742/the-effect-of-rituximab-on-anti-platelet-autoantibody-levels-in-patients-with-immune-thrombocytopenia
#1
Donald M Arnold, John R Vrbensky, Nadia Karim, James W Smith, Yang Liu, Nikola Ivetic, John G Kelton, Ishac Nazy
Rituximab is an effective therapy resulting in a platelet count improvement in 60% of patients with immune thrombocytopenia (ITP). Rituximab depletes B cells; thus, a reduction in platelet autoantibody levels would be anticipated in patients who achieve a clinical response to this treatment. The objectives of this study were to determine whether rituximab was associated with a reduction in platelet autoantibody levels, and to correlate the loss of autoantibodies with the achievement of a treatment response...
April 25, 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28442477/nobel-laureate-a-v-hill-and-the-refugee-scholars-1933-1945
#2
Jack A Rall
A. V. Hill shared the 1922 Nobel Prize in Physiology or Medicine for his investigation of the energetics of muscular contraction. His scientific work has been well chronicled over many years (Rall JA. Mechanism of Muscular Contraction, 2014). There is the natural tendency to focus solely on an investigator's scientific achievements. But in the case of Hill, it has been said (Katz B. Biogr Mem Fellows R Soc 24: 71-149, 1978) that "it was his devotion to such wider issues, outside the boundaries of his own research, through which he exerted his most important influence on other people's lives and on the course of events...
June 1, 2017: Advances in Physiology Education
https://www.readbyqxmd.com/read/28426734/study-of-deaths-by-suicide-of-homosexual-prisoners-in-nazi-sachsenhausen-concentration-camp
#3
Esther Cuerda-Galindo, Francisco López-Muñoz, Matthis Krischel, Astrid Ley
Living conditions in Nazi concentration camps were harsh and inhumane, leading many prisoners to commit suicide. Sachsenhausen (Oranienburg, Germany) was a concentration camp that operated from 1936 to 1945. More than 200,000 people were detained there under Nazi rule. This study analyzes deaths classified as suicides by inmates in this camp, classified as homosexuals, both according to the surviving Nazi files. This collective was especially repressed by the Nazi authorities. Data was collected from the archives of Sachsenhausen Memorial and the International Tracing Service in Bad Arolsen...
2017: PloS One
https://www.readbyqxmd.com/read/28418558/lectures-on-inhumanity-teaching-medical-ethics-in-german-medical-schools-under-nazism
#4
Florian Bruns, Tessa Chelouche
Nazi medicine and its atrocities have been explored in depth over the past few decades, but scholars have started to examine medical ethics under Nazism only in recent years. Given the medical crimes and immoral conduct of physicians during the Third Reich, it is often assumed that Nazi medical authorities spurned ethics. However, in 1939, Germany introduced mandatory lectures on ethics as part of the medical curriculum. Course catalogs and archival sources show that lectures on ethics were an integral part of the medical curriculum in Germany between 1939 and 1945...
April 18, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28399103/-k-birnbaum-s-concept-of-psychopathic-personalities
#5
N Yu Pyatnitskiy
K. Birnbaum's concept of psychopathic personalities is analyzed. K. Birnbaum was one of the first psychiatrists who had suggested the differentiation of psychopathic personalities according to the degree of social damage they caused. As personality abnormality classification according to one prominent trait that led to hiding signs of the general psychopathic constitution in clinical description, as the reliance on erroneous genetic theories with idealization of social behavior norms led to the antihuman medical recommendations...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28391124/performance-characteristics-of-an-automated-latex-immunoturbidimetric-assay-hemosil-%C3%A2-hit-ab-pf4-h-for-the-diagnosis-of-immune-heparin-induced-thrombocytopenia
#6
Theodore E Warkentin, Jo-Ann I Sheppard, Lori-Ann Linkins, Donald M Arnold, Ishac Nazy
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a prothrombotic drug reaction caused by platelet-activating anti-PF4/heparin antibodies. Given time-sensitive treatment considerations, a rapid and accurate laboratory test for HIT antibodies is needed. AIMS: To determine operating characteristics for the HemosIL(®) HIT-Ab(PF4/H), a rapid, on-demand, fully-automated, latex immunoturbidimetric assay (LIA), for diagnosis of HIT. METHODS: We evaluated LIA sensitivity, specificity, negative (NPV) and positive predictive value (PPV), negative (LR-) and positive likelihood ratio (LR+), using citrated-plasma from 429 patients (prospective cohort study of 4Ts scoring; HIT, n=31), and from consecutive HIT patients (n=125), using reference standard serotonin-release assay (SRA)...
March 11, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28389680/-attempting-a-great-integration-paul-martini-and-the-first-post-war-conference-of-the-german-society-for-internal-medicine
#7
Ralf Forsbach, Hans-Georg Hofer
The long established German Society for Internal Medicine (DGIM) profoundly incriminated itself through its actions and positions during the National Socialist era. The German clinical physician Paul Martini assumed the part of reorganizing the DGIM prior to its first post-war convention in 1948 in Karlsruhe. Martini, who himself had opposed the Nazi regime, adopted a course of comprehensive integration. He strived to incorporate both physicians who had been persecuted by the Nazi Regime as well as former moderate National Socialists into the DGIM...
April 7, 2017: NTM
https://www.readbyqxmd.com/read/28385619/medical-students-assessment-of-eduard-pernkopf-s-atlas-topographical-anatomy-of-man
#8
Demetrius M Coombs, Steven J Peitzman
INTRODUCTION: To date, there has been no study examining the perceptions of first-year medical students regarding Eduard Pernkopf's atlas, particularly during their study of gross anatomy and prior to coursework in medical ethics. We present a discussion of Pernkopf's Atlas: Topographical Anatomy of Man from the perspective of U.S. medical students, and sought to determine whether medical students view Pernkopf's Topographical Anatomy of Man as a resource of greater accuracy, detail, and potential educational utility as compared to Netter's Atlas of Human Anatomy...
April 3, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28377682/body-of-evidence-integrating-eduard-pernkopf-s-atlas-into-a-librarian-led-medical-humanities-seminar
#9
Keith C Mages, Linda A Lohr
BACKGROUND: Anatomical subjects depicted in Eduard Pernkopf's richly illustrated Topographische Anatomie des Menschen may be victims of the Nazi regime. Special collections librarians in the history of medicine can use this primary resource to initiate dialogs about ethics with medical students. CASE PRESENTATION: Reported here is the authors' use of Pernkopf's Atlas in an interactive medical humanities seminar designed for third-year medical students. Topical articles, illustrations, and interviews introduced students to Pernkopf, his Atlas, and the surrounding controversies...
April 2017: Journal of the Medical Library Association: JMLA
https://www.readbyqxmd.com/read/28374706/-eponyms-related-to-nazism-neurosciences
#10
I V Damulin
The author considers eponymous names of CNS diseases related to physicians who had actively cooperated with Nazis during the Second World War. The data on the activity of some specialists in the field of neurosciences whose activity did not correspond to ethical values of the physician and the scientist are presented. The author suggests excluding a number of eponymous terms associated with the names of physicians, former Nazis or those who actively cooperated with Nazis.
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28369702/the-unique-immunological-features-of-heparin-induced-thrombocytopenia
#11
REVIEW
Phillip Staibano, Donald M Arnold, Dawn M E Bowdish, Ishac Nazy
Heparin-induced thrombocytopenia (HIT) is a serious drug reaction that leads to a decrease in platelet count and a high risk of thrombosis. HIT patients produce pathogenic immunoglobulin G (IgG) antibodies that bind to complexes of platelet factor-4 (PF4) and heparin. HIT immune complexes crosslink Fc-receptors resulting in platelet and monocyte activation. These events lead to the release of procoagulant chemokines and tissue factor, which together create an intensely prothrombotic state. HIT represents an atypical immune response because it has features of both T cell-dependent and T cell-independent mechanisms...
April 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28325112/potential-of-personal-health-record-portals-in-the-care-of-individuals-with-spinal-cord-injuries-and-disorders-provider-perspectives
#12
Jennifer N Hill, Bridget M Smith, Frances M Weaver, Kim M Nazi, Florian P Thomas, Barry Goldstein, Timothy P Hogan
CONTEXT/OBJECTIVE: Although personal health record (PHR) portals are designed for patients, healthcare providers are a key influence in how patients use their features and realize benefits from them. A few studies have examined provider attitudes toward PHR portals, but none have focused on those who care for individuals with spinal cord injuries and disorders (SCI/D). We characterize SCI/D provider perspectives of PHR portals, including perceived advantages and disadvantages of PHR portal use in SCI/D care...
March 21, 2017: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/28289166/hans-jacob-and-brain-research-on-hamburg-euthanasia-victims-awaiting-further-brains
#13
Lawrence A Zeidman
Several neuropathologists conducted brain research on victims of so-called euthanasia programs carried out by the National Socialist (Nazi) regime in Germany from 1940 to 1945. Some published their results in German journals or books during and after the war. One of these neuropathologists was Hans Jacob of Hamburg, a former Nazi party member and the leader of the same laboratory previously run by Alfons Jakob (Creutzfeldt-Jakob disease). Though much has been published on the unethical actions of Jacob's fellow neuropathologist from Berlin, Julius Hallervorden, Jacob's actions were remarkably similar and have not been previously analyzed in the neuroscience literature...
March 14, 2017: Neurology
https://www.readbyqxmd.com/read/28202428/patient-use-of-electronic-prescription-refill-and-secure-messaging-and-its-association-with-undetectable-hiv-viral-load-a-retrospective-cohort-study
#14
D Keith McInnes, Stephanie L Shimada, Amanda M Midboe, Kim M Nazi, Shibei Zhao, Justina Wu, Casey M Garvey, Thomas K Houston
BACKGROUND: Electronic personal health records (PHRs) can support patient self-management of chronic conditions. Managing human immunodeficiency virus (HIV) viral load, through taking antiretroviral therapy (ART) is crucial to long term survival of persons with HIV. Many persons with HIV have difficulty adhering to their ART over long periods of time. PHRs contribute to chronic disease self-care and may help persons with HIV remain adherent to ART. Proportionally veterans with HIV are among the most active users of the US Department of Veterans Affairs (VA) PHR, called My HealtheVet...
February 15, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28166420/does-early-life-trauma-affect-how-depression-is-experienced-by-holocaust-survivors-in-late-life
#15
Norm O'Rourke, Sara Carmel, Yaacov G Bachner
OBJECTIVES: Existing research indicates that early life trauma increases the likelihood of depression in later life. This includes children who survived the Nazi Holocaust living in Israel today. For this study, we set out to examine whether early life trauma affects both levels of depression symptomatology and the relative prominence of certain facets of depression as compared to other older adults in Israel and Canada. METHOD: For this study we recruited 295 Holocaust survivors (HS), 205 other Israelis and 335 older Canadians each of whom completed Radloff's (1977) Center for Epidemiological Studies - Depression Scale (CES-D)...
February 6, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28088867/the-political-use-of-psychiatry-a-comparison-between-totalitarian-regimes
#16
Massimiliano Buoli, Aldo Sabino Giannuli
BACKGROUND: After the end of Second World War, the recent experience of the Nazi horrors stimulated a debate about the political use of psychiatry. Over the years, the focus shifted on major dictatorships of the time and especially on Soviet Union. AIMS: This article aims to provide a critical review of the ways in which psychiatry was used by totalitarian regimes of the 20th century. METHODS: We summarized relevant literature about political use of psychiatry in totalitarian regimes of the 20th century, with particular focus on Fascism, Nazism, Argentina dictatorship, Soviet Union and China...
January 1, 2017: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/28079093/tilikum-dies-us-antibiotic-ban-and-a-nazi-science-probe
#17
(no author information available yet)
No abstract text is available yet for this article.
January 11, 2017: Nature
https://www.readbyqxmd.com/read/28077842/psychoanalysis-and-the-emigration-of-central-and-eastern-european-intellectuals
#18
Ferenc Erős
One of the most important phenomena in the intellectual history of the 20th century was the exodus of the European mind, the emigration of persons, ideas, techniques, and institutions in the vast areas of social, human, and natural sciences, as well as in literature and the visual arts. Among these exiled intellectuals, psychoanalysts formed a special group. This paper examines the major lines of the emigration of psychoanalysts from the countries of issue to the countries of reception. It focuses, in particular on Hungarian analysts and analytic candidates who left their country of birth in two waves, first after the failure of revolutions in 1918/19 for Berlin, and then after 1938, to escape the Nazis...
December 2016: American Journal of Psychoanalysis
https://www.readbyqxmd.com/read/28059721/germany-to-probe-nazi-era-medical-science
#19
Megan Gannon
No abstract text is available yet for this article.
January 6, 2017: Science
https://www.readbyqxmd.com/read/28032138/holocaust-exposure-and-subsequent-suicide-risk-a-population-based-study
#20
Cendrine Bursztein Lipsicas, Itzhak Levav, Stephen Z Levine
OBJECTIVES: To examine the association between the extent of genocide exposure and subsequent suicide risk among Holocaust survivors. METHODS: Persons born in Holocaust-exposed European countries during the years 1922-1945 that immigrated to Israel by 1965 were identified in the Population Registry (N = 209,429), and followed up for suicide (1950-2014). They were divided into three groups based on likely exposure to Nazi persecution: those who immigrated before (indirect; n = 20,229; 10%), during (partial direct; n = 17,189; 8%), and after (full direct; n = 172,061; 82%) World War II...
December 28, 2016: Social Psychiatry and Psychiatric Epidemiology
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