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Sunil Sazawal, Usha Dhingra, Pratibha Dhingra, Arup Dutta, Saikat Deb, Jitendra Kumar, Prabhabati Devi, Ashish Prakash
BACKGROUND: Biofortification of staple food crops with zinc (Zn) can be one of the cost-effective and sustainable strategies to combat zinc deficiency and prevent morbidity among the target population. Agronomic approaches such as application of Zn fertilizers to soil and/or foliar spray seem to be a practical tool for Zn biofortification of wheat. However, there is a need to evaluate its efficacy from randomized controlled trials. This study aimed to evaluate the efficacy of zinc biofortified wheat flour on zinc status and its impact on morbidity among children aged 4-6 years and non-pregnant non lactating woman of child bearing age (WCBA) in Delhi, India...
September 15, 2018: Nutrition Journal
Olivier Mir, Analia Azaro, Jaime Merchan, Rashmi Chugh, Jonathan Trent, Jordi Rodon, Ute Ohnmacht, J T Diener, Claire Smith, Eunice Yuen, Gerard Joseph Oakley, Axel Le Cesne, Jean-Charles Soria, Karim A Benhadji, Christophe Massard
BACKGROUND: LY3039478 is an orally bioavailable selective Notch inhibitor. This phase 1a/b trial evaluated the safety, pharmacokinetics and antitumour activity of LY3039478 in patients with soft tissue sarcoma (STS) and gastrointestinal stromal tumour (GIST). METHODS: This multipart, phase 1 trial enrolled patients with refractory advanced/metastatic STS and GIST, measurable disease, Eastern Cooperative Oncology Group ≤1 and baseline tumour tissue. Eligible patients received LY3039478 50mg/75 mg three times per week, for 28-day cycle until disease progression...
September 12, 2018: European Journal of Cancer
M Tarazi, C L English, K Guest, D Balasubramaniam
INTRODUCTION: Inflammatory myofibroblastic tumours (IMTs), are uncommon tumours which can act with malignant potential. The management of these tumours can be extremely problematic but are often referred to surgical multi-disciplinary team meetings with the intention of surgical and oncological management (Chaudhary [1]). CASE REPORT: A 69-year-old gentleman was admitted with a 2-day history of abdominal pain and vomiting, and a 4-day history of absolute constipation...
September 6, 2018: International Journal of Surgery Case Reports
Kamyar Iravani, Peyman Jafari, Allahkaram Akhlaghi, Bijan Khademi
BACKGROUND: The European Organization for Research and Treatment of Cancer QOL Core Questionnaire 30 (EORTC QLQ-30) and the Assessment of Cancer Therapy-General (FACT-G) are the two most widely used measures of cancer-specific health-related quality of life (HRQOL). This study aims to assess whether the two instruments measure the same constructs of HRQOL in patients with total laryngectomy. METHODS: The EORTC QLQ-30 and the FACT-G was completed by 132 patients with total laryngectomy...
September 14, 2018: Health and Quality of Life Outcomes
Carin E Reust, Amy Williams
Recurrent abdominal pain (RAP) in children is defined as at least three episodes of pain that occur over at least three months and affect the child's ability to perform normal activities. RAP is most often considered functional (nonorganic) abdominal pain, but an organic cause is found in 5% to 10% of cases. Further workup is warranted in children who have RAP and fever, vomiting, blood in the stool, more than three alarm symptoms, or a history of urinary tract infections. Physical examination findings that should prompt further workup include weight loss or failure to grow; jaundice; costovertebral tenderness or back pain with lower extremity neurologic symptoms; liver, spleen, or kidney enlargement; an abdominal mass; or localized tenderness on abdominal examination...
June 15, 2018: American Family Physician
Kozina A Anastasiya, Okuneva G Elena, Baryshnikova V Natalia, Krasnenko Yu Anna, Tsukanov Yu Kirill, Klimchuk I Olesya, Nikishina A Tatiana, Fedoniuk D Inessa, Surkova I Ekaterina, Shatalov A Peter, Ilinsky V Valery
We report a Russian patient with atypical onset of infantile nephropathic cystinosis. The disease debuted with vomiting and loss of weight and motor skills. Nephropathic changes appeared 6 months after onset of disease. Exome sequencing can be useful for diagnosing cystinosis in patients with neurological abnormalities before onset of nephropathic symptoms.
September 2018: Clinical Case Reports
Jinli Li, Xiaoyan Chai, Ying Cao, Xiaochu Hu, Hongyu Zhu, Jianping Wang, Yiwei Wu
Short-term efficacy, adverse effects and the impact on quality of life (QoL) of a concomitant treatment with intensity-modulated radiation therapy (IMRT) and temozolomide (TMZ) in patients with brain metastases (BMs) from lung adenocarcinoma were evaluated. This study sought to confirm the benefit of adding TMZ to IMRT in patients with BMs from lung adenocarcinoma. Nine patients were enrolled and received a dose of 30 Gy in 10 daily fractions to clinical tumor volume (CTV) according to IMRT, then additional dose of 9 Gy in 3 fractions of IMRT was delivered to gross tumor volume (GTV) only with concomitant TMZ (75 mg/m2 /day) orally during RT for 3 weeks...
October 2018: Oncology Letters
Hui Wang, Hefang Wang, Zhichong Yu, Honghao Liu
Introduction: This meta-analysis was conducted to evaluate efficacy and safety in patients treated with sorafenib vs other tyrosine-kinase inhibitors (TKIs) or selective internal radiotherapy (SIRT) for advanced hepatocellular carcinoma (HCC). Methods: Electronic databases were systematically reviewed for randomized Phase III trials comparing sorafenib with other TKIs or SIRT in advanced HCC. Sorafenib was defined as the control arm. Other TKIs or SIRT was defined as the experimental arm...
2018: OncoTargets and Therapy
Larissa Hines, Jill Glick, Kristin Bilka, John D Lantos
The Food and Drug Administration categorizes marijuana (cannabis) as a Schedule I drug, meaning that it has no currently accepted medical use, a high potential for abuse, and no good data on safety. Other Schedule I drugs are heroin, lysergic acid diethylamide, peyote, methaqualone, and 3,4-methylenedioxymethamphetamine ("ecstasy"). The authors of some studies have shown that marijuana can reduce nausea and vomiting from chemotherapy, can improve food intake in patients with HIV, can reduce neuropathic pain, and may slow the growth of cancer cells...
September 13, 2018: Pediatrics
Seiya Miyamoto, Takehiko Sugita, Toshimi Aizawa, Naohisa Miyatake, Akira Sasaki, Ikuo Maeda, Masayuki Kamimura, Atsushi Takahashi
BACKGROUND: The efficacy of morphine added to periarticular multimodal drug injection (PMDI) for pain management after total knee arthroplasty (TKA) is controversial. Adding morphine to spinal anesthesia has reportedly improved pain relief for the first 24 h. We examined the effect of morphine added to PMDI or spinal anesthesia on pain management and functional recovery after TKA. METHODS: A total of 97 patients were randomized into three groups: in Group A (34 patients), 10 mg morphine was added to PMDI; Group B (31 patients), 0...
September 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
Wenxian Wang, Guangyuan Lou, Yiping Zhang
Olanzapine is an atypical antipsychotic that has shown efficacy for the treatment of nausea, anxiety, and insomnia. This study was conducted to evaluate the efficacy of olanzapine (5 mg) combined with 5-HT3 receptor antagonists and dexamethasone for the prevention of chemotherapy-induced nausea and vomiting (CINV) in lung patients receiving cisplatin-based (25 mg/m2 d1-3) highly emetogenic chemotherapy (HEC).Olanzapine (5 mg) was administered a day prior to cisplatin administration and continued on days 1 to 5...
September 2018: Medicine (Baltimore)
Tian-Hua Zhang, De-Cai Chi, Wei-Liang Jiang, Shuai Qiang
RATIONALE: Abdominal aortic aneurysm is one of the most common aneurisms. Patients presenting with secondary back pain should be given prompt medical attention. Herein, a rare case of a giant abdominal aortic aneurysm that was successfully treated with surgery is described. PATIENT CONCERNS: A 33-year-old Chinese male suffered from Marfan syndrome combined with giant abdominal aortic aneurysm, and presented with back pain, fever, nausea, vomiting, abdominal distention, and constipation...
September 2018: Medicine (Baltimore)
Kadie M Anderson, Michael M Garner, Victoria L Clyde, Kurt A Volle, Donna M Ialeggio, Scott W Reid, Jill K Hobbs, Karen N Wolf
CASE DESCRIPTION 10 large felids at 8 facilities were determined or suspected to have developed gastric dilatation with or without enterotoxemia over a 20-year period. Four felids were found dead with no premonitory signs. CLINICAL FINDINGS 4 felids (2 male snow leopards [Uncia uncia], 1 male Amur tiger [Panthera tigris altaica], and 1 male Sumatran tiger [Panthera tigris sumatrae]) were found dead or died before they could be evaluated. Six felids had hematemesis (1 male and 1 female African lion [Panthera leo] and 1 male jaguar [Panthera onca]) or abdominal distention and signs of lethargy with or without vomiting (1 male African lion, 1 male Malayan tiger [Panthera tigris jacksoni], and 1 female Sumatran tiger)...
October 1, 2018: Journal of the American Veterinary Medical Association
Jimin Han, Matthew Chin, Kyle J Fortinsky, Reem Sharaiha, Christopher J Gostout, Kenneth J Chang
Background and study aims  This preliminary study was conducted to determine the feasibility and safety of endoscopic augmentation of the gastroesophageal junction (GEJ) using the Apollo OverStitch endoscopic suturing system in patients with gastroesophageal reflux disease (GERD) symptoms. Patients and methods  Endoscopic augmentation of GEJ was performed on 10 consecutive patients and the data were analyzed retrospectively. Using a double-channel gastroscope affixed to the endoscopic suturing platform, interrupted sutures were placed on the gastric side of the GEJ in 2 layers in order to create a narrowed and elongated GEJ...
September 2018: Endoscopy International Open
Ebrahim Khadem, Mahboobeh Shirazi, Leila Janani, Roja Rahimi, Parastoo Amiri, Fereshteh Ghorat
Objective: Postoperative ileus (POI) is a common complication after surgery that requires a multifactorial therapeutic approach. This study aims to assess the effect of topical chamomile oil on postoperative bowel activity after cesarian section. Methods: This randomized controlled trial was carried out in 2015 at Chamran Hospital in Iran. A block randomization list was generated for 142 parturient divided into three groups. In the intervention group (arm A) ( n = 47), chamomile oil was applied topically on abdominal region after the stability of the patient...
July 2018: Journal of Research in Pharmacy Practice
Ya-Hong He, Lei Lu, Yu-Fang Wang, Jin-Song Huang, Wei-Qin Zhu, Yan Guo, Chun-Xia Li, Hua-Ming Li
Acute pancreatitis is rarely associated with drugs. Acetaminophen overdose is a well-known cause of hepatic toxicity, but drug-induced pancreatitis is rarely reported, especially after mild overdose. A 32-year-old woman presented with nausea and vomiting for 12 h, but no abdominal pain following an overdose of eight Tylenol tablets containing acetaminophen (325 mg acetaminophen per tablet). Laboratory results on admission showed abnormal amylase and lipase levels but completely normal liver function. Magnetic resonance cholangiopancreatography revealed mild swelling of the pancreas without fluid collection around the pancreas...
September 6, 2018: World Journal of Clinical Cases
Jenifer Molina, Marta Hervera, Edgar Garcia Manzanilla, Carlos Torrente, Cecilia Villaverde
Hospitalized dogs are predisposed to undernutrition, which can potentially affect outcome. This study evaluated the prevalence of undernutrition in hospitalized dogs (measured as loss of body condition score, BCS and body weight, BW) and studied the risk factors that affect nutritional status, and outcome (discharge or death). Data was collected prospectively during 9 months from 500 hospitalized dogs with a hospitalization length longer than 24 h in a veterinary teaching hospital in Spain. The BCS and BW changes were modeled using multiple linear regression and outcome was modeled using logistic regression...
2018: Frontiers in Veterinary Science
Naima Baddouh, Lahcen Arjdal, Abdelaziz Raji, Mounir Bourrous
Summary: Foreign bodies in esophagus are avoidable accidents that occur most often in children younger than 3 years. The most common presenting symptoms are dysphagia, drooling, and vomiting. Revelation by respiratory distress is a rare and unusual condition. Objective: We describe and discuss the case of an esophageal foreign body, in which the patient presented with respiratory distress. Case report: A two-year-old child was admitted to the emergency department for acute respiratory distress...
2018: Case Reports in Pediatrics
Feride Fatma Görgülü, Ayşe Selcan Koç, Orhan Görgülü
Adenotonsillectomy is a common surgical otolaryngology procedure that is associated with several complications, including hemorrhage, odynophagia, damage to teeth, taste disorders, atlantoaxial subluxation, lingual edema, infection, and injury of the carotid artery. Pneumomediastinum, pneumopericardium, and epidural pneumatosis are an extremely unusual condition in children with adenotonsillectomy. Treatment should be conservative in the majority of cases and based on benign self-limiting course of these diseases; early recognition can prevent further complications...
2018: Case Reports in Otolaryngology
Pingping Li, Chao Qin
Deficiency of protein C may cause deep venous thrombosis and pulmonary embolism, leading to ischemic stroke. The present study reports on a case of a young adult with recurrent cerebellar infarction due to hereditary heterozygous protein C deficiency and performs a literature review. A 35-year-old Asian woman was admitted t o the Department of Neurology of The First Affiliated Hospital of Guangxi Medical University (Nanning, China) due to right limb paralysis and vomiting. The diagnosis of stroke was confirmed by computed tomography and magnetic resonance imaging, which indicated acute cerebral infarction of the right cerebellar hemisphere and cerebellar vermis, as well as a previous cerebral infarction on the left cerebellar hemisphere...
September 2018: Experimental and Therapeutic Medicine
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