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Translational stroke

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https://www.readbyqxmd.com/read/29651951/inflammatory-events-following-subarachnoid-hemorrhage-sah
#1
U C Schneider, R Xu, P Vajkoczy
Acute SAH from a ruptured intracranial aneurysm contributes for 30% of all hemorrhagic strokes. The bleeding itself occurs in the subarachnoid space. Nevertheless, injury to the brain parenchyma occurs as a consequence of the bleeding, directly, via several well-defined mechanisms and pathways, but also indirectly, or secondarily. This secondary brain injury following SAH has a variety of causes and possible mechanisms. Amongst others, inflammatory events have been shown to occur in parallel to, to contribute to, or even to initiate programmed cell death (PCD) within the central nervous system (CNS) in human and animal studies alike...
April 11, 2018: Current Neuropharmacology
https://www.readbyqxmd.com/read/29650593/human-neural-stem-cell-extracellular-vesicles-improve-recovery-in-a-porcine-model-of-ischemic-stroke
#2
Robin L Webb, Erin E Kaiser, Brian J Jurgielewicz, Samantha Spellicy, Shelley L Scoville, Tyler A Thompson, Raymond L Swetenburg, David C Hess, Franklin D West, Steven L Stice
BACKGROUND AND PURPOSE: Recent work from our group suggests that human neural stem cell-derived extracellular vesicle (NSC EV) treatment improves both tissue and sensorimotor function in a preclinical thromboembolic mouse model of stroke. In this study, NSC EVs were evaluated in a pig ischemic stroke model, where clinically relevant end points were used to assess recovery in a more translational large animal model. METHODS: Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO), and either NSC EV or PBS treatment was administered intravenously at 2, 14, and 24 hours post-MCAO...
April 12, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29650408/normothermic-ex-vivo-preservation-with-the-portable-organ-care-system-lung-device-for-bilateral-lung-transplantation-inspire-a-randomised-open-label-non-inferiority-phase-3-study
#3
Gregor Warnecke, Dirk Van Raemdonck, Michael A Smith, Gilbert Massard, Jasleen Kukreja, Federico Rea, Gabriel Loor, Fabio De Robertis, Jayan Nagendran, Kumud K Dhital, Francisco Javier Moradiellos Díez, Christoph Knosalla, Christian A Bermudez, Steven Tsui, Kenneth McCurry, I-Wen Wang, Tobias Deuse, Guy Lesèche, Pascal Thomas, Igor Tudorache, Christian Kühn, Murat Avsar, Bettina Wiegmann, Wiebke Sommer, Arne Neyrinck, Marco Schiavon, Fiorella Calebrese, Nichola Santelmo, Anne Olland, Pierre-Emanuel Falcoz, Andre R Simon, Andres Varela, Joren C Madsen, Marshall Hertz, Axel Haverich, Abbas Ardehali
BACKGROUND: Severe primary graft dysfunction (PGD) of grade 3 (PGD3) is a common serious complication following lung transplantation. We aimed to assess physiological donor lung preservation using the Organ Care System (OCS) Lung device compared with cold static storage. METHODS: In this non-inferiority, randomised, controlled, open-label, phase 3 trial (INSPIRE) recipients were aged 18 years or older and were registered as standard criteria primary double lung transplant candidates...
April 9, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29650382/therapeutic-decisions-in-atrial-fibrillation-for-stroke-prevention-the-role-of-aversion-to-ambiguity-and-physicians-risk-preferences
#4
Luciano A Sposato, Devin Stirling, Gustavo Saposnik
BACKGROUND: Knowledge-to-action gaps influence therapeutic decisions in atrial fibrillation (AF). Physician-related factors are common, but the least studied. We evaluated the prevalence and determinants of physician-related factors and knowledge-to-action gaps among physicians involved in the management of AF patients. DESIGN: In this cross-sectional study, participants from 6 South American countries recruited during an educational program answered questions regarding 16 case scenarios of patients with AF and completed experiments assessing 3 outcome measures: therapeutic inertia, herding, and errors in risk stratification knowledge translated into action (ERSKTA) based on commonly used stratification tools (Congestive heart failure, Hypertension, Age ≥75 years (double), Diabetes mellitus, previous Stroke/transient ischemic attack/thromboembolism (double), Vascular disease, Age 65-74 years, and female gender (score of 0 for males and 1 for female) (CHA2 DS2 -VASc) and Congestive heart failure, Hypertension, Age ≥75 years, Diabetes mellitus, and previous Stroke/transient ischemic attack (double) (CHADS2 ))...
April 9, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29649992/protocol-for-promoting-recovery-optimization-of-walking-activity-in-stroke-prowalks-a-randomized-controlled-trial
#5
Henry Wright, Tamara Wright, Ryan T Pohlig, Scott E Kasner, Jonathan Raser-Schramm, Darcy Reisman
BACKGROUND: Stroke survivors are more physically inactive than even the most sedentary older adults, and low activity is associated with increased risk of recurrent stroke, medical complications, and mortality. We hypothesize that the combination of a fast walking intervention that improves walking capacity, with a step activity monitoring program that facilitates translation of gains from the clinic to the "real-world", would generate greater improvements in real world walking activity than with either intervention alone...
April 12, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29625597/how-do-we-incorporate-patient-views-into-the-design-of-healthcare-services-for-older-people-a-discussion-paper
#6
Paul R Brocklehurst, Gerald McKenna, Martin Schimmel, Anastassia Kossioni, Katarina Jerković-Ćosić, Martina Hayes, Cristiane da Mata, Frauke Müller
BACKGROUND: Across the European Union costs for the treatment of oral disease is expected to rise to €93 Billion by 2020 and be higher than those for stroke and dementia combined. A significant proportion of these costs will relate to the provision of care for older people. Dental caries severity and experience is now a major public health issue in older people and periodontal disease disproportionately affects older adults. Poor oral health impacts on older people's quality of life, their self-esteem, general health and diet...
April 6, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29620280/melatonin-protects-brain-against-ischemia-reperfusion-injury-by-attenuating-endoplasmic-reticulum-stress
#7
Yu Wen Lin, Tsung Ying Chen, Chia Yang Hung, Shih Huang Tai, Sheng Yang Huang, Che Chao Chang, Hsin Yi Hung, E Jian Lee
Endoplasmic reticulum (ER) stress plays a vital role in mediating ischemic reperfusion damage in brain. In this study, we evaluated whether melatonin inhibits ER stress in cultured neurons exposed to oxygen and glucose deprivation (OGD) and in rats subjected to transient focal cerebral ischemia. Sprague-Dawley rats were treated with melatonin (5 mg/kg) or control at reperfusion onset after transient occlusion of the right middle cerebral artery (MCA) for 90 min. Brain infarction and hemorrhage within infarcts were measured...
March 30, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29618983/perivascular-adipose-tissue-as-a-relevant-fat-depot-for-cardiovascular-risk-in-obesity
#8
REVIEW
Rafael M Costa, Karla B Neves, Rita C Tostes, Núbia S Lobato
Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure. However, this is not a straightforward relationship. Although several studies have substantiated that obesity confers an independent and additive risk of all-cause and cardiovascular death, there is significant variability in these associations, with some lean individuals developing diseases and others remaining healthy despite severe obesity, the so-called metabolically healthy obese...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29618555/basic-and-translational-research-in-intracerebral-hemorrhage-limitations-priorities-and-recommendations
#9
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
April 4, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29616203/non-invasive-brain-stimulation-in-children-with-unilateral-cerebral-palsy-a-protocol-and-risk-mitigation-guide
#10
Bernadette T Gillick, Andrew M Gordon, Tim Feyma, Linda E Krach, Jason Carmel, Tonya L Rich, Yannick Bleyenheuft, Kathleen Friel
Non-invasive brain stimulation has been increasingly investigated, mainly in adults, with the aims of influencing motor recovery after stroke. However, a consensus on safety and optimal study design has not been established in pediatrics. The low incidence of reported major adverse events in adults with and without clinical conditions has expedited the exploration of NIBS in children with paralleled purposes to influence motor skill development after neurological injury. Considering developmental variability in children, with or without a neurologic diagnosis, adult dosing and protocols may not be appropriate...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29615352/long-term-comparative-effectiveness-of-carotid-stenting-versus-carotid-endarterectomy-in-a-large-tertiary-care-vascular-surgery-practice
#11
Robert P Garvin, Evan J Ryer, Andrea L Berger, James R Elmore
OBJECTIVE: Carotid interventional trials have strict inclusion and exclusion criteria that make translation of their results to the real-world population challenging. Furthermore, the specialty of the operating surgeon and the role of clinical decision-making are not well studied. This study compares the effectiveness of carotid endarterectomy (CEA) vs carotid artery stenting (CAS) in a real-world setting when the procedure is performed by fellowship-trained vascular surgeons. METHODS: A retrospective study was conducted of all consecutive patients undergoing CEA and CAS performed by vascular surgeons in a large rural tertiary health care system from 2004 to 2014...
March 31, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29587253/early-and-one-year-outcomes-of-acute-stroke-in-the-industrial-region-of-poland-during-the-decade-2006-2015-the-silesian-stroke-registry
#12
Marek Gierlotka, Beata Labuz-Roszak, Bogdan Wojtyniak, Anetta Lasek-Bal, Tomasz Zdrojewski, Monika Adamczyk-Sowa, Kamil Chwojnicki, Michal Skrzypek, Daniel Ciesla, Mariusz Gasior
BACKGROUND: Poland, classified as a high-income country, is still considered to have a high cardiovascular risk population. During the last decade, the standards of care in acute stroke (AS) had markedly improved; thus, we aimed to assess whether and how it translated into early and late outcomes. METHODS: Silesian Stroke Registry was created from the administrative database of the public, obligatory, health -insurer in Poland. The AS cases were selected based on primary diagnosis coded in ICD-10 as I60-I64 for years 2006-2015 (n = 120,844)...
March 27, 2018: Neuroepidemiology
https://www.readbyqxmd.com/read/29580113/platelet-biomechanics-platelet-bioenergetics-and-applications-to-clinical-practice-and-translational-research
#13
Mitchell J George, James Bynum, Prajeeda Nair, Andrew P Cap, Charles E Wade, Charles S Cox, Brijesh S Gill
The purpose of this review is to explore the relationship between platelet bioenergetics and biomechanics and how this relationship affects the clinical interpretation of platelet function devices. Recent experimental and technological advances highlight platelet bioenergetics and biomechanics as alternative avenues for collecting clinically relevant data. Platelet bioenergetics drive energy production for key biomechanical processes like adhesion, spreading, aggregation, and contraction. Platelet function devices like thromboelastography, thromboelastometry, and aggregometry measure these biomechanical processes...
March 26, 2018: Platelets
https://www.readbyqxmd.com/read/29575885/periodontal-condition-in-patients-of-the-specialist-outpatient-clinics-at-the-institute-of-rural-health-in-lublin-poland
#14
Agnieszka Pawłowicz, Teresa Bachanek, Magdalena Klijer, Renata Chałas
INTRODUCTION: Periodontal disease is a chronic inflammation which, if remains untreated, can lead to the loss of teeth and supporting structures. Evidence data support the relationship of periodontal disease with the development and course of diseases such as heart attack, stroke, hypertension, chronic renal diseases, rheumatoid arthritis or diabetes. OBJECTIVE: The aim of the study was to conduct an assessment of periodontal status and periodontal needs in people from the rural environment who were patients of selected specialist outpatient clinics at the Institute of Rural Health in Lublin, Poland...
March 14, 2018: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29575417/translation-and-validation-study-for-the-stroke-self-efficacy-questionnaire-in-stroke-survivors
#15
Serpil Topçu, Sıdıka Oğuz
BACKGROUND: Self-efficacy has been shown to play an important role in rehabilitation outcomes of stroke patients. AIM: This study aimed to determine the validity and reliability of a Turkish translation of the Stroke Self-Efficacy Questionnaire. METHODS: This methodological study was conducted in a private acute stroke unit in Istanbul, Turkey. After obtaining the Institutional Review Board's approval and site consent, a translated version of the 13-item Likert-type scaled questions was tested for language and content validity...
March 25, 2018: International Journal of Nursing Practice
https://www.readbyqxmd.com/read/29572690/human-ischaemic-cascade-studies-using-sh-sy5y-cells-a-systematic-review-and-meta-analysis
#16
Ye Liu, Emma D Eaton, Taryn E Wills, Sarah K McCann, Ana Antonic, David W Howells
Low translational yield for stroke may reflect the focus of discovery science on rodents rather than humans. Just how little is known about human neuronal ischaemic responses is confirmed by systematic review and meta-analysis revealing that data for the most commonly used SH-SY5Y human cells comprises only 84 papers. Oxygen-glucose deprivation, H2 O2 , hypoxia, glucose-deprivation and glutamate excitotoxicity yielded - 58, - 61, - 29, - 45 and - 49% injury, respectively, with a dose-response relationship found only for H2 O2 injury (R2  = 29...
March 23, 2018: Translational Stroke Research
https://www.readbyqxmd.com/read/29565039/discovery-and-development-of-na-1-for-the-treatment-of-acute-ischemic-stroke
#17
REVIEW
Beatrice Ballarin, Michael Tymianski
Stroke creates a complex interplay of multiple signaing pathways including excitotoxicity, ionic imbalance, inflammation, oxidative stress and apoptosis. There are very few treatments that have been shown to be beneficial in acute stroke. Recent findings have provided insights into the pathophysiology and mechanisms of ischemic stroke, complementing the traditional glutamate hypothesis: the molecular interaction between PSD95 and GluN2B has been identified as a culprit in stroke-mediated excitotoxicity, leading to the discovery of NA-1, a peptide that disrupts that interaction, as a potent neuroprotective agent for the treatment of acute stroke...
March 22, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29556835/impact-of-randomized-controlled-trials-on-neurosurgical-practice-in-decompressive-craniectomy-for-ischemic-stroke
#18
Thomas Beez, Hans-Jakob Steiger
Randomized controlled trials (RCTs) are gold standard for comparing treatment modalities. Recently, RCTs transformed ischemic stroke care by first proving benefit of decompressive craniectomy (DC) and later of interventional mechanical thrombectomy. Aim of this study was to explore the impact of RCTs on neurosurgical practice. RCTs investigating DC and thrombectomy were identified. Annual numbers of DCs for ischemic stroke between 2000 and 2017 were determined and correlated with publication dates of RCTs. The initial RCTs demonstrating efficacy of DC were published in 2007, followed by an increase in DC numbers between 2008 and 2009...
March 19, 2018: Neurosurgical Review
https://www.readbyqxmd.com/read/29554692/trends-in-racial-ethnic-and-nativity-disparities-in-cardiovascular-health-among-adults-without-prevalent-cardiovascular-disease-in-the-united-states-1988-to-2014
#19
Arleen F Brown, Li-Jung Liang, Stefanie D Vassar, Jose J Escarce, Sharon Stein Merkin, Eric Cheng, Adam Richards, Teresa Seeman, W T Longstreth
Background: Trends in cardiovascular disparities are poorly understood, even as diversity increases in the United States. Objective: To examine U.S. trends in racial/ethnic and nativity disparities in cardiovascular health. Design: Repeated cross-sectional study. Setting: NHANES (National Health and Nutrition Examination Survey), 1988 to 2014. Participants: Adults aged 25 years or older who did not report cardiovascular disease...
March 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29542796/reconfigurable-paramagnetic-microswimmers-brownian-motion-affects-non-reciprocal-actuation
#20
Di Du, Elaa Hilou, Sibani Lisa Biswal
Swimming at low Reynolds number is typically dominated by a large viscous drag, therefore microscale swimmers require non-reciprocal body deformation to generate locomotion. Purcell described a simple mechanical swimmer at the microscale consisting of three rigid components connected together with two hinges. Here we present a simple microswimmer consisting of two rigid paramagnetic particles with different sizes. When placed in an eccentric magnetic field, this simple microswimmer exhibits non-reciprocal body motion and its swimming locomotion can be directed in a controllable manner...
March 15, 2018: Soft Matter
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