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AYA oncology

Marie-Estelle Gaignard, Julie Bénard, Noémie Lang
Every year, cancer affects more than a million adolescents and young adults (AYA) in high-income countries. AYA patients represent a heterogeneous but distinct population, aged from 15 to 39 (-45) years old, among which different types of cancer are found compared to the ones affecting children and older adults. Although these pathologies remain the leading cause of death in the AYA age range, the survival rate in this population has significantly improved in recent years, averaging 85%. The aim of this article is to review one major issue in AYA survivors, which is the risk of impaired fertility due to oncological treatments, and the different strategies available to address this problem...
March 14, 2018: Revue Médicale Suisse
Victor M Orellana-Noia, Michael G Douvas
PURPOSE OF REVIEW: Adolescent and Young Adult (AYA) Oncology is a relatively new field encompassing research in the unique pathophysiology, clinical care, and psychosocial issues facing patients between the ages of 15 and 40 with cancer. About 100,000 of the approximately 1.5 million people diagnosed annually with cancer in the USA are in this age range. This chapter will review notable new developments in the care of adolescents and young adults with acute lymphoblastic leukemia (ALL) within the last 3 years...
February 14, 2018: Current Hematologic Malignancy Reports
Anita Vallacha, Ghulam Haider, Wiky Raja, Dinesh Kumar
OBJECTIVE: To determine the remission rate in adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Department of Oncology, Jinnah Postgraduate Medical Centre (JPMC), Karachi from January, 2016 to March, 2017. METHODOLOGY: Adolescent and young adult (AYA) patients aged 15-39 years, newly diagnosed with acute lymphoblastic leukemia from January, 2016 to March, 2017...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Emily E Johnston, Elysia Alvarez, Olga Saynina, Lee M Sanders, Smita Bhatia, Lisa J Chamberlain
BACKGROUND: Studies of adolescent and young adult (AYA) oncology end-of-life care utilization are critical because cancer is the leading cause of nonaccidental AYA death and end-of-life care contributes significantly to health care expenditures. This study was designed to determine the quantity of and disparities in inpatient utilization in the last year of life of AYAs with cancer. METHODS: The California Office of Statewide Health Planning and Development administrative discharge database, linked to death certificates, was used to perform a population-based analysis of cancer patients aged 15 to 39 years who died in 2000-2011...
February 2, 2018: Cancer
Laura Mitchell, Jeremy Lewin, Julia Dirks, Kate Wang, Seline Tam, Anne Katz, Beth McCann, Kirk Lo, Valerie Laurence, Christine Rousset-Jablonski, Abha A Gupta
Sexual health is an important consideration for young adults with cancer; however, oncology healthcare providers are often not equipped with strategies to approach these problems in a systematic way. To address this gap in adolescents and young adults (AYA) care, a one-day international Sexual Health Symposium was held before the Global AYA Cancer Congress (Edinburgh, December 2016). The goals of the symposium were to (1) provide a forum, where international AYA experts had the opportunity to share their knowledge regarding AYA sexual health and (2) develop a guideline for healthcare professionals to screen for and intervene on sexual health issues...
January 10, 2018: Journal of Adolescent and Young Adult Oncology
Diana Richter, Anja Mehnert, Florian Schepper, Katja Leuteritz, Crystal Park, Jochen Ernst
BACKGROUND: Cancer has adverse effects on patient's quality of life. As such, measuring quality of life (QoL) has become an integral part of psycho-oncological health care. Because adolescent and young adult patients have different needs in contrast to children and older cancer patients, instruments for adequately measuring QoL of cancer survivors in this age range are essential. As there is not a corresponding instrument in Germany, we aimed to validate the German version of the Late Adolescence and Young Adulthood Survivorship-Related Quality of Life Measure (LAYA-SRQL), a 30-item questionnaire covering 10 dimensions related to QoL...
January 4, 2018: Health and Quality of Life Outcomes
Justine M Kahn, Nmazuo W Ozuah, Kieron Dunleavy, Tara O Henderson, Kara Kelly, Ann LaCasce
Lymphomas are responsible for approximately 20% to 25% of annual cancer diagnoses in the adolescent and young adult (AYA) population. In 2006, the National Cancer Institute and the Lance Armstrong Foundation developed a joint Adolescent and Young Adult Oncology Progress Review Group (AYAO-PRG) to formally address the unique cancer burden of patients age 15 to 39 years. As part of their recommendations, the AYAO-PRG identified 5 imperatives for improving outcomes of AYAs with cancer. Broadly, the recommended areas of focus included research, awareness and education, investigational infrastructure, care delivery, and advocacy...
October 10, 2017: Blood Advances
Peter F Coccia, Alberto S Pappo, Lynda Beaupin, Virginia F Borges, Scott C Borinstein, Rashmi Chugh, Shira Dinner, Jeanelle Folbrecht, A Lindsay Frazier, Robert Goldsby, Alexandra Gubin, Robert Hayashi, Mary S Huang, Michael P Link, John A Livingston, Yousif Matloub, Frederick Millard, Kevin C Oeffinger, Diane Puccetti, Damon Reed, Steven Robinson, Abby R Rosenberg, Tara Sanft, Holly L Spraker-Perlman, Margaret von Mehren, Daniel S Wechsler, Kimberly F Whelan, Nicholas Yeager, Lisa A Gurski, Dorothy A Shead
This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology focuses on treatment and management considerations for AYA patients with cancer. Compared with older adults with cancer, AYA patients have unique needs regarding treatment, fertility counseling, psychosocial and behavioral issues, and supportive care services. The complete version of the NCCN Guidelines for AYA Oncology addresses additional aspects of caring for AYA patients, including risk factors, screening, diagnosis, and survivorship...
January 2018: Journal of the National Comprehensive Cancer Network: JNCCN
Yelena P Wu, Lauri A Linder, Patsaporn Kanokvimankul, Brynn Fowler, Bridget G Parsons, Catherine F Macpherson, Rebecca H Johnson
OBJECTIVES: To explore the feasibility and acceptability of use of a smartphone medication reminder application to promote adherence to oral medications among adolescents and young adults (AYAs) with cancer.
. SAMPLE & SETTING: 23 AYAs with cancer from a Children's Oncology Group-affiliated children's hospital and a National Cancer Institute-designated comprehensive cancer center in Salt Lake City, UT.
. METHODS & VARIABLES: Participants were asked to use the application for eight weeks...
January 1, 2018: Oncology Nursing Forum
Joseph R Henderson, Elizabeth Kiernan, Jennifer L McNeer, Angie Mae Rodday, Katherine Spencer, Tara O Henderson, Susan K Parsons
PURPOSE: Advances in health-related quality-of-life (HRQL) measurement enable point-of-care assessments. We incorporated the Patient-Reported Outcomes Measurement Information System (PROMIS® ) Global Health Scale in routine outpatient evaluations of adolescent and young adult (AYA) oncology patients and survivors at two geographically distinct U.S. institutions. METHODS: AYAs (18-39 years old) completed the 10-question PROMIS Global. Summary subscale scores for Global Physical Health (GPH) and Global Mental Health (GMH) were produced using established scoring algorithms (standardized mean = 50, standard deviation = 10)...
February 2018: Journal of Adolescent and Young Adult Oncology
Konstantin A Krauth
No abstract text is available yet for this article.
November 20, 2017: Oncology Research and Treatment
J M Snaman, A C Talleur, J Lu, D R Levine, E C Kaye, A Sykes, Z Lu, B M Triplett, J N Baker
Adolescent and young adult (AYA) oncology patients experience many physical and psychological symptoms at the end of life (EOL); however, data on these experiences for AYA patients who have undergone hematopoietic cell transplantation (HCT) remains sparse. We sought to investigate the characteristics of AYA patients aged 15-25 years who received allogeneic HCT and subsequently died while inpatient at our institution between the years 2008 and 2014. A standardized data extraction tool was used to collect information about patient demographics, treatment and symptoms...
November 13, 2017: Bone Marrow Transplantation
Yousery Nada, Noha Rashad, Mai Eissa, Aya Ghonaim, Kyrillus Farag, Islam Saadawi, Ahmed Sheha, Mahmoud El Gewaity, Omar Abdel-Rahman
BACKGROUND: Sorafenib is the standard of care, first line treatment for advanced HCC. This study aims to evaluate real-life efficacy and safety of sorafenib in Egyptian patients with Hepatocellular carcinoma (HCC). RESEARCH DESIGN AND METHODS: This retrospective cohort study was conducted in the medical oncology department at Maadi Armed Forces Medical Compound. Patients with advanced HCC who received sorafenib between January and December 2015 were included (130 patients)...
November 10, 2017: Expert Review of Gastroenterology & Hepatology
Kolina Koltai, Casey Walsh, Barbara Jones, Brenda L Berkelaar
PURPOSE: This article examines how theoretical and clinical applications of social network analysis (SNA) can inform opportunities for innovation and advancement of social support programming for adolescent and young adult (AYA) cancer patients and survivors. APPLICATIONS: SNA can help address potential barriers and challenges to initiating and sustaining AYA peer support by helping to identify the diverse psychosocial needs among individuals in the AYA age range; find strategic ways to support and connect AYAs at different phases of the cancer trajectory with resources and services; and increase awareness of psychosocial resources and referrals from healthcare providers...
November 6, 2017: Journal of Adolescent and Young Adult Oncology
Gabriel Lopez, Wenli Liu, Kevin Madden, Bryan Fellman, Yisheng Li, Eduardo Bruera
PURPOSE: Integrative Oncology (IO) consultations offer cancer patients counseling regarding complementary integrative medicine (CIM). We explored the CIM interests and symptom burden of AYA cancer patients presenting for an IO consultation. METHODS: Patients referred for an IO physician consultation at an academic medical center from September 1, 2009 to December 31, 2013 completed an assessment on presentation: MYCaW, ESAS (10 symptoms, 0-10, 10 worst possible), CIM use survey, and SF-12 QOL survey...
October 29, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Michal Zapotocky, Vijay Ramaswamy, Alvaro Lassaletta, Eric Bouffet
Adolescents and young adults (AYA) comprise a specific group of oncology patients with a distinct biological and epidemiological spectrum of central nervous system neoplasms. It has been well documented that they differ clinically, especially in relation to prognosis and chemotherapy tolerance; however, the underlying reasons for this are unclear. Recent advances in the genomics of both childhood and adult brain tumors have provided new explanations and insights into the previously described age-dependent heterogeneity...
October 19, 2017: Pediatric Blood & Cancer
Emmanouil Saloustros, Daniel P Stark, Kyriaki Michailidou, Giannis Mountzios, Laurence Brugieres, Fedro Alessandro Peccatori, Svetlana Jezdic, Samira Essiaf, Jean-Yves Douillard, Stefan Bielack
INTRODUCTION: Adolescents and young adults (AYA) with cancer require dedicated clinical management and care. Little is known about the training and practice of European healthcare providers in regard to AYA and the availability of specialised services. METHODS: A link to an online survey was sent to members of the European Society for Medical Oncology (ESMO) and the European Society for Paediatric Oncology (SIOPE). The link was also sent to ESMO National Representatives and circulated to other European oncology groups...
2017: ESMO Open
Linda Overholser, Kristin Kilbourn, Arthur Liu
Adolescent and young adult (AYA) individuals with a history of cancer make up a fraction of the total number of cancer survivors in the United States, but they represent a population with needs distinct from either the childhood or the older adult cancer populations. Fertility concerns, psychosocial factors, and health care access are just a few of the distinguishing characteristics. Caring for AYA cancer survivors presents unique opportunities for primary care providers to collaborate with oncology colleagues to minimize the long-term cancer burden...
November 2017: Medical Clinics of North America
Ronald D Barr, W Archie Bleyer
Adolescents and young adults (AYAs - ages 15 to 39) constitute approximately 40% of the world's population and contribute an estimated one million new cases of cancer annually, the great majority in low- and middle-income countries (LMICs). In high-income countries (HICs) cancer is the commonest cause of disease-related death in AYAs, though overall 5-year survival rates now exceed 80%. A very different circumstance likely holds in LMICs, but accurate assessments are not readily available.Breast cancer accounts for 40% of tumours in female AYAs and this age group includes the peak incidence of Hodgkin lymphoma...
November 23, 2017: Tumori
Kodai Takahashi, Eiji Kanehira, Aya Kamei, Takashi Tanida, Kazunori Sasaki
BACKGROUND: In general, laparoscopic resection for gastric gastrointestinal stromal tumors (GISTs) >5 cm is not recommended. However, there is a lack of evidence to support this recommendation. PATIENTS AND METHODS: This study included 108 patients who underwent laparoscopic surgery for gastric GISTs. Of the 108 patients, 23 had GISTs>5 cm. The aim of this study is to evaluate the oncological safety of laparoscopic surgery for large gastric GISTs. In addition, we performed a rapid systematic review of laparoscopic surgery for large gastric GISTs...
December 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
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