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AYA oncology

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https://www.readbyqxmd.com/read/29785559/childbirth-after-adolescent-and-young-adult-cancer-a-population-based-study
#1
Hazel B Nichols, Chelsea Anderson, Kathryn J Ruddy, Kristin Z Black, Barbara Luke, Stephanie M Engel, Jennifer E Mersereau
PURPOSE: Annually, > 45,000 US women are diagnosed with cancer during adolescence and young adulthood (AYA). Since 2006, national guidelines have recommended fertility counseling for cancer patients. We examined childbirth after AYA cancer by calendar period, cancer diagnosis, and maternal characteristics. METHODS: We identified a cohort of women with an incident invasive AYA cancer diagnosis at ages 15-39 during 2000-2013 in North Carolina. Cancer records were linked with statewide birth certificates through 2014...
May 22, 2018: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/29770995/adolescent-and-young-adult-oncology-patients-in-france-heterogeneity-in-pathways-of-care
#2
Emmanuel Desandes, Laurence Brugières, Florence Molinié, Gautier Defossez, Patricia Delafosse, Karine Jehannin-Ligier, Michel Velten, Brigitte Trétarre, Brice Amadéo, Emilie Marrer, Anne-Sophie Woronoff, Olivier Ganry, Alain Monnereau, Tania d'Almeida, Xavier Troussard, Laetitia Daubisse-Marliac, Simona Bara, Anne-Valérie Guizard, Isabelle Baldi, Guy Launoy, Jacqueline Clavel, Brigitte Lacour
BACKGROUND: In order to evaluate at the population level the impact of the actions developed in France since 2004 to organize the care of adolescents and young adults (AYAs) with cancer, we conducted the present study to provide an unbiased view of the pathway of care of these patients. METHODS: Using a population-based registry, we conducted a review of all cases of cancer diagnosed during 2012 and 2013 in 15- to 24-year-old patients living in nineteen French administrative areas...
May 17, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29769263/how-i-treat-burkitt-lymphoma-in-children-adolescents-and-young-adults-in-sub-saharan-africa
#3
Satish Gopal, Thomas G Gross
Burkitt lymphoma (BL) is the most common pediatric cancer in sub-Saharan Africa (SSA), and also occurs frequently among adolescents and young adults (AYA), often associated with human immunodeficiency virus (HIV). Treating BL in SSA poses particular challenges. Although highly effective, high-intensity cytotoxic treatments used in resource-rich settings are usually not feasible, and lower-intensity continuous infusion approaches are impractical. In this paper, based on evidence from the region, we review management strategies for SSA focused on diagnosis, use of pre-phase, and definitive treatment...
May 16, 2018: Blood
https://www.readbyqxmd.com/read/29761898/clinical-impact-of-muscle-quantity-and-quality-in-colorectal-cancer-patients-a-propensity-score-matching-analysis
#4
Yoshinaga Okugawa, Yuji Toiyama, Akira Yamamoto, Tsunehiko Shigemori, Chengzeng Yin, Aya Narumi, Yusuke Omura, Shozo Ide, Takahito Kitajima, Hiroyuki Fujikawa, Hiromi Yasuda, Junichiro Hiro, Shigeyuki Yoshiyama, Minako Kobayashi, Toshimitsu Araki, Donald C McMillan, Chikao Miki, Masato Kusunoki
BACKGROUND: Sarcopenia is defined as the loss of skeletal muscle mass, accompanied by decreased muscle strength, and consists of myopenia and myosteatosis. Recent evidence has suggested the predictive value of sarcopenia for the risk of perioperative and oncological outcomes in various malignancies. The aim of this study was to clarify the clinical impact of myopenia and myosteatosis in colorectal cancer (CRC) patients. METHODS: We analyzed the preoperative psoas muscle mass index and intramuscular adipose tissue content using preoperative computed tomography images from 308 CRC patients using statistical methods...
May 15, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29746187/queensland-youth-cancer-service-a-partnership-model-to-facilitate-access-to-quality-care-for-young-people-diagnosed-with-cancer
#5
Natalie K Bradford, Roslyn Henney, Rick Walker, Euan Walpole, Glen Kennedy, Wayne Nicholls, Ross Pinkerton
Global recognition of the need to improve outcomes for adolescents and young adults (AYA) with cancer has led to the development of specific oncology programs and services. In Australia, Youth Cancer Services (YCS) are now established across the country. While each service has been shaped by nationally agreed principles, program development has been influenced by local policy and geographic differences. Queensland is a vast state with a widely dispersed population; coordination of cancer services for young people across this landscape presents unique challenges...
May 10, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29723084/patient-navigation-preferences-for-adolescent-and-young-adult-cancer-services-by-distance-to-treatment-location
#6
Echo L Warner, Brynn Fowler, Samantha T Pannier, Sara K Salmon, Douglas Fair, Holly Spraker-Perlman, Jeffrey Yancey, R Lor Randall, Anne C Kirchhoff
PURPOSE: To describe how distance to treatment location influences patient navigation preferences for adolescent and young adult (AYA) cancer patients and survivors. METHODS: This study is part of a statewide needs assessment to inform the development of an AYA cancer patient and survivor navigation program. Participants were recruited from outpatient oncology clinics in Utah. Eligible participants had been diagnosed with cancer between ages 15-39 and had completed at least 1 month of treatment...
May 3, 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29722656/patterns-of-involved-field-radiation-therapy-protocol-deviations-in-pediatric-versus-adolescent-and-young-adults-with-hodgkin-lymphoma-a-report-from-the-children-s-oncology-group-ahod0031
#7
Aaron Parzuchowski, Rizvan Bush, Qinglin Pei, Debra L Friedman, Thomas J FitzGerald, Suzanne L Wolden, Kavita V Dharmarajan, Louis S Constine, Fran Laurie, Sandy K Kessel, Burton Appel, Karen Fernandez, Angela Punnett, Cindy L Schwartz, Jacob Cox, Stephanie A Terezakis
PURPOSE: The presented protocol for pediatric intermediate-risk Hodgkin lymphoma evaluated the use of a dose-intensive chemotherapy regimen (ABVE-PC [doxorubicin, bleomycin, vincristine, etoposide, cyclophosphamide, prednisone]) with response-based therapy augmentation (addition of DECA [dexamethasone, etoposide, cisplatin, cytarabine]) or therapy reduction (elimination of radiation). METHODS AND MATERIALS: A central review of the radiation therapy data for quality assurance was performed, and the association between radiation protocol deviation (RPD) and relapse was assessed in the pediatric group (age <15 years) and adolescent and young adult (AYA) group (age ≥15-21 years)...
April 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29697189/barriers-and-facilitators-to-sexual-and-reproductive-health-communication-between-pediatric-oncology-clinicians-and-adolescent-and-young-adult-patients-the-clinician-perspective
#8
Natasha N Frederick, Kevin Campbell, Lisa B Kenney, Kerry Moss, Ashley Speckhart, Sharon L Bober
BACKGROUND: Sexual and reproductive health (SRH) is identified by adolescent and young adult (AYA) patients with cancer as an important but often neglected aspect of their comprehensive cancer care. The purpose of this study was to investigate the attitudes and perceptions of pediatric oncology clinicians towards discussing SRH with AYAs, and to understand perceived barriers to effective communication in current practice. PROCEDURE: Pediatric oncology clinicians (physicians, certified nurse practitioners, and physician assistants) participated in semi-structured qualitative interviews investigating attitudes about SRH communication with AYAs and barriers to such conversations...
April 26, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29696424/survivorship-care-models-for-breast-cancer-colorectal-cancer-and-adolescent-and-young-adult-aya-cancer-survivors-a-systematic-review
#9
REVIEW
Yu Ke, Terence Ng, Alexandre Chan
BACKGROUND: Well-elucidated survivorship care models are pertinent in the long-term management of cancer survivors. This review aims to update existing literature and evaluate the key components of such models with a focus on breast, colorectal, and adolescent and young adult (AYA) cancer survivors. METHODS: The PubMed electronic database were searched comprehensively for relevant publications in English through February 2017. Additional manual searches were conducted for reference lists and official guidelines published by oncology societies...
April 25, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29669756/patterns-of-care-and-outcomes-in-adolescent-and-young-adult-acute-lymphoblastic-leukemia-a-population-based-study
#10
Lori Muffly, Elysia Alvarez, Daphne Lichtensztajn, Renata Abrahão, Scarlett Lin Gomez, Theresa Keegan
Adolescents and young adults (AYAs, 15-39 years) with acute lymphoblastic leukemia (ALL) represent a heterogeneous population who receive care in pediatric or adult cancer settings. Using the California Cancer Registry, we describe AYA ALL patterns of care and outcomes over the past decade. Sociodemographics, treatment location, and front-line therapies administered to AYAs diagnosed with ALL between 2004 and 2014 were obtained. Cox regression models evaluated associations between ALL setting and regimen and overall survival (OS) and leukemia-specific survival (LSS) for the entire cohort, younger AYA (<25 years), and AYAs treated in the adult cancer setting only...
April 24, 2018: Blood Advances
https://www.readbyqxmd.com/read/29667766/role-of-clinical-trials-in-survival-progress-of-american-adolescents-and-young-adults-with-cancer-and-lack-thereof
#11
Archie Bleyer, Eric Tai, Stuart Siegel
In the United States, adolescent and young adult (AYA) patients with cancer have the lowest clinical trial participation rate of all age groups and slower progress in survival improvement than younger patients. Ominously, AYA clinical trial participation has been steadily decreasing since 2010, except in 15-19 year olds and AYAs with acute lymphoblastic leukemia. In order to reverse the accrual trend, multiple changes are necessary, including convincing community oncologists to pursue clinical trials on behalf of their AYA patients and to have the new National Community Oncology Research Program and National Clinical Trials Network lead a coordinated effort to increase accrual...
April 18, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29644783/prevalence-of-mental-disorders-and-psychosocial-distress-in-german-adolescent-and-young-adult-cancer-patients-aya
#12
Kristina Geue, Elmar Brähler, Hermann Faller, Martin Härter, Holger Schulz, Joachim Weis, Uwe Koch, Hans-Ulrich Wittchen, Anja Mehnert
OBJECTIVE: This study provides prevalence data of mental disorders (four-week, one-year, lifetime) and psychological distress in AYAs with cancer. METHODS: We included an AYA-subsample (15 to 39 year olds; diagnosed within the last 5 years) extracted from a larger sample (4.020 cancer patients) who had been recruited for an epidemiological study across all major tumor entities. Participants were assessed with a depression screener (PHQ-9). Following that, 50% of the participants who scored below the cutoff of 9 and all patients who scored above were assessed using the Composite International Diagnostic Interview for Oncology (CIDI-O)...
April 12, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29611779/the-association-of-metacognitive-beliefs-with-emotional-distress-and-trauma-symptoms-in-adolescent-and-young-adult-survivors-of-cancer
#13
Peter L Fisher, Kirsten McNicol, Mary Gemma Cherry, Bridget Young, Ed Smith, Gareth Abbey, Peter Salmon
PURPOSE/OBJECTIVES: Adolescent and young adults who have survived cancer are at an increased risk of psychological distress. This study investigated whether metacognitive beliefs are associated with emotional distress and trauma symptoms in adolescent and young adult (AYA) survivors of cancer independent of known covariates, including current physical health difficulties. DESIGN: Cross-sectional survey using multiple self-report measures. SAMPLE AND METHODS: Eighty-seven AYA survivors of cancer were recruited from follow-up appointments at an oncology unit and completed self-report questionnaires measuring emotional distress, posttraumatic stress symptoms, metacognitive beliefs, demographic information, and current physical health difficulties...
April 3, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29603618/adolescent-and-young-adult-hodgkin-lymphoma-raising-the-bar-through-collaborative-science-and-multidisciplinary-care
#14
REVIEW
Justine M Kahn, Kara M Kelly
Hodgkin lymphoma (HL) is one of the most common cancers in the adolescent and young adult (AYA) population (15-39 years). Despite continued improvements in HL outcomes, AYAs have not exhibited survival gains to the same extent as other age groups. At present, details about tumor biology, optimal therapeutic approaches, supportive care needs, and long-term toxicities in AYAs with HL remain understudied. Herein, we summarize the current state of the AYA population with HL, specifically focusing on how collaborations across the pediatric and medical oncology divide, coupled with multidisciplinary patient care, can further optimize outcomes for this group of patients...
March 30, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29537742/-fertility-and-cancer-in-young-adults-cured-but-what-about-having-children
#15
Marie-Estelle Gaignard, Julie Bénard, Noémie Lang
Every year, cancer affects more than a million adolescents and young adults (AYA) in high-income countries. AYA patients represent a heterogeneous but distinct population, aged from 15 to 39 (-45) years old, among which different types of cancer are found compared to the ones affecting children and older adults. Although these pathologies remain the leading cause of death in the AYA age range, the survival rate in this population has significantly improved in recent years, averaging 85%. The aim of this article is to review one major issue in AYA survivors, which is the risk of impaired fertility due to oncological treatments, and the different strategies available to address this problem...
March 14, 2018: Revue Médicale Suisse
https://www.readbyqxmd.com/read/29442287/recent-developments-in-adolescent-and-young-adult-aya-acute-lymphoblastic-leukemia
#16
REVIEW
Victor M Orellana-Noia, Michael G Douvas
PURPOSE OF REVIEW: Adolescent and Young Adult (AYA) Oncology is a relatively new field encompassing research in the unique pathophysiology, clinical care, and psychosocial issues facing patients between the ages of 15 and 40 with cancer. About 100,000 of the approximately 1.5 million people diagnosed annually with cancer in the USA are in this age range. This chapter will review notable new developments in the care of adolescents and young adults with acute lymphoblastic leukemia (ALL) within the last 3 years...
April 2018: Current Hematologic Malignancy Reports
https://www.readbyqxmd.com/read/29394970/remission-rate-of-acute-lymphoblastic-leukemia-all-in-adolescents-and-young-adults-aya
#17
Anita Vallacha, Ghulam Haider, Wiky Raja, Dinesh Kumar
OBJECTIVE: To determine the remission rate in adolescent and young adult (AYA) patients with acute lymphoblastic leukemia (ALL). STUDY DESIGN: Descriptive study. PLACE AND DURATION OF STUDY: Department of Oncology, Jinnah Postgraduate Medical Centre (JPMC), Karachi from January, 2016 to March, 2017. METHODOLOGY: Adolescent and young adult (AYA) patients aged 15-39 years, newly diagnosed with acute lymphoblastic leukemia from January, 2016 to March, 2017...
February 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/29393967/inpatient-utilization-and-disparities-the-last-year-of-life-of-adolescent-and-young-adult-oncology-patients-in-california
#18
Emily E Johnston, Elysia Alvarez, Olga Saynina, Lee M Sanders, Smita Bhatia, Lisa J Chamberlain
BACKGROUND: Studies of adolescent and young adult (AYA) oncology end-of-life care utilization are critical because cancer is the leading cause of nonaccidental AYA death and end-of-life care contributes significantly to health care expenditures. This study was designed to determine the quantity of and disparities in inpatient utilization in the last year of life of AYAs with cancer. METHODS: The California Office of Statewide Health Planning and Development administrative discharge database, linked to death certificates, was used to perform a population-based analysis of cancer patients aged 15 to 39 years who died in 2000-2011...
April 15, 2018: Cancer
https://www.readbyqxmd.com/read/29319398/sexual-health-issues-for-the-young-adult-with-cancer-an-international-symposium-held-during-the-first-global-adolescents-and-young-adults-cancer-congress-edinburgh-united-kingdom
#19
Laura Mitchell, Jeremy Lewin, Julia Dirks, Kate Wang, Seline Tam, Anne Katz, Beth McCann, Kirk Lo, Valerie Laurence, Christine Rousset-Jablonski, Abha A Gupta
Sexual health is an important consideration for young adults with cancer; however, oncology healthcare providers are often not equipped with strategies to approach these problems in a systematic way. To address this gap in adolescents and young adults (AYA) care, a one-day international Sexual Health Symposium was held before the Global AYA Cancer Congress (Edinburgh, December 2016). The goals of the symposium were to (1) provide a forum, where international AYA experts had the opportunity to share their knowledge regarding AYA sexual health and (2) develop a guideline for healthcare professionals to screen for and intervene on sexual health issues...
April 2018: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/29301526/validation-of-the-german-version-of-the-late-adolescence-and-young-adulthood-survivorship-related-quality-of-life-measure-laya-srql
#20
Diana Richter, Anja Mehnert, Florian Schepper, Katja Leuteritz, Crystal Park, Jochen Ernst
BACKGROUND: Cancer has adverse effects on patient's quality of life. As such, measuring quality of life (QoL) has become an integral part of psycho-oncological health care. Because adolescent and young adult patients have different needs in contrast to children and older cancer patients, instruments for adequately measuring QoL of cancer survivors in this age range are essential. As there is not a corresponding instrument in Germany, we aimed to validate the German version of the Late Adolescence and Young Adulthood Survivorship-Related Quality of Life Measure (LAYA-SRQL), a 30-item questionnaire covering 10 dimensions related to QoL...
January 4, 2018: Health and Quality of Life Outcomes
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