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Lobular cancerization

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https://www.readbyqxmd.com/read/29132567/lobular-breast-cancer-different-disease-different-algorithms
#1
REVIEW
Anita Mamtani, Tari A King
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer, with a unique pathogenesis and distinct clinical biology. ILCs display a characteristic loss of E-cadherin, are largely estrogen receptor positive, HER2 negative, and low to intermediate grade. These features portend a favorable prognosis, but there is a tendency for late recurrences and atypical metastases. ILCs tend to be insidious and infiltrative, which can pose a challenge for diagnosis, and emerging data suggest they may have a propensity for a differing response to standard therapies...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29132563/when-does-atypical-ductal-hyperplasia-require-surgical-excision
#2
REVIEW
Jennifer M Racz, Amy C Degnim
Atypical ductal hyperplasia (ADH) is a proliferative, nonobligate precursor breast lesion and a marker of increased risk for breast carcinoma. Surgical excision remains the standard recommendation following a core needle biopsy result consistent with ADH. Recent research suggests that women with no mass lesion or discordance, removal of greater than or equal to 90% of calcifications at the time of core needle biopsy, involvement of less than or equal to 2 terminal duct lobular units, and absence of cytologic atypia or necrosis are likely to have a less than 5% chance of a missed cancer...
January 2018: Surgical Oncology Clinics of North America
https://www.readbyqxmd.com/read/29131161/rapid-virtual-hematoxylin-and-eosin-histology-of-breast-tissue-specimens-using-a-compact-fluorescence-nonlinear-microscope
#3
Lucas C Cahill, Michael G Giacomelli, Tadayuki Yoshitake, Hilde Vardeh, Beverly E Faulkner-Jones, James L Connolly, Chi-Kuang Sun, James G Fujimoto
Up to 40% of patients undergoing breast conserving surgery for breast cancer require repeat surgeries due to close to or positive margins. The lengthy processing required for evaluating surgical margins by standard paraffin-embedded histology precludes its use during surgery and therefore, technologies for rapid evaluation of surgical pathology could improve the treatment of breast cancer by reducing the number of surgeries required. We demonstrate real-time histological evaluation of breast cancer surgical specimens by staining specimens with acridine orange (AO) and sulforhodamine 101 (SR101) analogously to hematoxylin and eosin (H&E) and then imaging the specimens with fluorescence nonlinear microscopy (NLM) using a compact femtosecond fiber laser...
November 13, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29127760/preoperative-breast-mri-examination-for-all-patients-with-histologically-proven-breast-cancer-a-concept-for-a-prospective-multicenter-trial
#4
Christina Kaiser, Christina Kehrer, Mignon-Denise Keyver-Paik, Thomas Hecking, Tiyasha Hosne Ayub, Claudia Leutner, Hans Schild, Walther Kuhn
Background A published retrospective data of our study group demonstrated that premenopausal women, patients with lobular invasive breast cancer or patients with high breast density [American College of Radiology (ACR) classification 3+4] significantly benefit from magnetic resonance imaging (MRI) leading to additional detection of malignant foci of 20.2% in the index and 2.5% in the contralateral breast, which would otherwise not be detected by routine imaging. Critics of preoperative MRI focus on higher false-positive rates leading to unnecessary surgical procedures and mastectomies...
November 11, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29124544/reproductive-risk-factor-associations-with-lobular-and-ductal-carcinoma-in-the-carolina-breast-cancer-study
#5
Lindsay A Williams, Hazel B Nichols, Katherine A Hoadley, Chiu Kit Tse, Joseph Geradts, Mary Elizabeth Bell, Charles M Perou, Michael I Love, Andrew F Olshan, Melissa A Troester
BACKGROUND: Invasive lobular breast tumors display unique reproductive risk factor profiles. Lobular tumors are predominantly Luminal A subtype, and it is unclear whether reported risk factor associations are independent of molecular subtype. METHODS: Polytomous logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (95% CIs) for the associations between risk factors and histologic subtype [ductal (n = 2,856), lobular (n = 326), and mixed ductal-lobular (n = 473)] in the Carolina Breast Cancer Study (1993-2013)...
November 9, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29119353/impact-of-microinvasion-on-breast-cancer-mortality-in-women-with-ductal-carcinoma-in-situ
#6
Victoria Sopik, Ping Sun, Steven A Narod
BACKGROUND: Ductal carcinoma in situ (DCIS) is a neoplastic proliferation of epithelial cells which is confined within the basement membrane of the mammary ductal-lobular system. It is of interest to determine to what extent the potential to metastasize increases for DCIS patients when the basement membrane is breached (i.e. microinvasion is present). METHODS: We retrieved the records of 525,395 women who had either first primary DCIS or small (≤ 2.0 cm) node-negative invasive breast cancer in the Surveillance, Epidemiology and End Results (SEER) registries database (1990-2013)...
November 8, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29113371/change-in-risk-of-breast-cancer-after-receiving-hormone-replacement-therapy-by-considering-effect-modifiers-a-systematic-review-and-dose-response-meta-analysis-of-prospective-studies
#7
Kang Wang, Feng Li, Li Chen, Yan-Mei Lai, Xiang Zhang, Hong-Yuan Li
We synthesize the current literatures and use the power of meta-analysis to examine trends on association between hormone replacement therapy (HRT) and the risk of breast cancer (BC). We performed a comprehensive literature search using PubMed, EMBASE, and Web of Science from their inception until Jan 2017. Prospective studies that provided adjusted risk estimates of HRT and BC risk were eligible. Categorical and dose-response meta-analyses followed the PRISMA were conducted using random effects model and restricted cubic spline model, respectively...
October 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/29109259/proof-of-region-specific-multipotent-progenitors-in-human-breast-epithelia
#8
Agla J Fridriksdottir, René Villadsen, Mikkel Morsing, Marie Christine Klitgaard, Jiyoung Kim, Ole William Petersen, Lone Rønnov-Jessen
The human breast parenchyma consists of collecting ducts and terminal duct lobular units (TDLUs). The TDLU is the site of origin of most breast cancers. The reason for such focal susceptibility to cancer remains poorly understood. Here, we take advantage of a region-specific heterogeneity in luminal progenitors to interrogate the differentiation repertoire of candidate stem cells in TDLUs. We show that stem-like activity in serial passage culture and in vivo breast morphogenesis relies on the preservation of a myoepithelial phenotype...
November 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29105963/does-the-use-of-pretreatment-mri-change-the-management-of-patients-with-newly-diagnosed-breast-cancer
#9
James Hlubocky, Sharukh Bhavnagri, Ann Swinford, Carol Mitri, Murray Rebner, Vidya Pai
Breast MRI plays a critical role in the diagnosis and management of breast cancer. The purpose of this study is to evaluate the effect of preoperative breast MRI on the management of a large cohort of breast cancer patients at our institution. This study is a retrospective chart review of all newly diagnosed breast cancer patients who underwent preoperative breast MRI at our institution between January 1, 2004 and December 31, 2009. 1352 patients comprised the study population. 241 (17.8%) patients underwent a change in surgical management as a result of preoperative MRI...
November 5, 2017: Breast Journal
https://www.readbyqxmd.com/read/29102711/pleomorphic-lobular-carcinoma-in-situ-diagnosed-by-breast-core-biopsy-clinicopathologic-features-and-correlation-with-subsequent-excision
#10
Tianhua Guo, Yihong Wang, Nella Shapiro, Susan Fineberg
INTRODUCTION: Pleomorphic lobular carcinoma in situ (PLCIS) is a variant of LCIS with high-grade morphologic features. The number of case series studying PLCIS is limited, and clinical management of patients with PLCIS is controversial. We report a breast core biopsy (BCBx) series of PLCIS. MATERIALS AND METHODS: We reviewed 37 cases of PLCIS with or without microinvasion diagnosed by BCBx. PLCIS was defined as dyscohesive cells showing acinar expansion and loss of immunohistochemical membranous expression of e-cadherin or beta-catenin with nuclear pleomorphism with at least 2- to 3-fold variation in nuclear size, membrane irregularities, and variably prominent nucleoli...
October 7, 2017: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29100673/flat-epithelial-atypia-upgrade-rates-and-risk-stratification-approach-to-support-informed-decision-making
#11
Leslie R Lamb, Manisha Bahl, Michele A Gadd, Constance D Lehman
BACKGROUND: Our aim was to determine upgrade rates of pure flat epithelial atypia (FEA) to malignancy and higher-risk lesions and to identify patients with FEA at low risk for upgrade. STUDY DESIGN: Medical chart review from 2007 to 2016 identified 208 consecutive patients with pure FEA diagnosed by image-guided core needle biopsy who underwent surgical excision (96.2% [200 of 208]) or had at least 2 years of imaging follow-up (3.8% [8 of 208]). Medical records were reviewed for risk factors and surgical outcomes...
September 27, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/29100415/the-e2f-activators-control-multiple-mitotic-regulators-and-maintain-genomic-integrity-through-sgo1-and-bubr1
#12
Miyoung Lee, Yainyrette Rivera-Rivera, Carlos S Moreno, Harold I Saavedra
The E2F1, E2F2, and E2F3a transcriptional activators control proliferation. However, how the E2F activators regulate mitosis to maintain genomic integrity is unclear. Centrosome amplification (CA) and unregulated spindle assembly checkpoint (SAC) are major generators of aneuploidy and chromosome instability (CIN) in cancer. Previously, we showed that overexpression of single E2F activators induced CA and CIN in mammary epithelial cells, and here we show that combined overexpression of E2F activators did not enhance CA...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29095484/quantitative-evaluation-of-contrast-agent-uptake-in-standard-fat-suppressed-dynamic-contrast-enhanced-mri-examinations-of-the-breast
#13
Evanthia Kousi, Joely Smith, Araminta E Ledger, Erica Scurr, Steven Allen, Robin M Wilson, Elizabeth O'Flynn, Romney J E Pope, Martin O Leach, Maria A Schmidt
PURPOSE: To propose a method to quantify T1 and contrast agent uptake in breast dynamic contrast enhanced (DCE) examinations undertaken with standard clinical fat-suppressed MRI sequences and to demonstrate the proposed approach by comparing the enhancement characteristics of lobular and ductal carcinomas. METHODS: A standard fat-suppressed DCE of the breast was performed at 1.5T (Siemens Aera), followed by the acquisition of a proton density (PD) weighted sequence, also fat suppressed...
November 2, 2017: Medical Physics
https://www.readbyqxmd.com/read/29090670/the-epithelial-mesenchymal-transition-pathway-in-two-cases-with-gastric-metastasis-originating-from-breast-carcinoma-one-with-a-metachronous-primary-gastric-cancer
#14
Simona Gurzu, Laura Banias, Tivadar Bara, Istvan Feher, Tivadar Jr Bara, Ioan Jung
BACKGROUND: Metastases to the stomach are extremely rare and the metastatic pathway is not well understood. OBJECTIVE: To present two unusual gastric metastases and a review of the literature regarding the pathway of epithelial mesenchymal transition (EMT) in the metastatic cells. METHOD: The clinicopathological aspects of the two cases were presented in the light of the most recent patents. Data about patents were obtained from the online databases PubMed, World Intellectual Property Organization (WIPO) and Google patents...
November 1, 2017: Recent Patents on Anti-cancer Drug Discovery
https://www.readbyqxmd.com/read/29084054/columnar-cell-lesion-and-apocrine-hyperplasia-of-the-breast-is-there-a-common-origin-the-role-of-prolactin-induced-protein
#15
Amedeo Sciarra, Gianluca Lopez, Chiara Corti, Letterio Runza, Giulia Ercoli, Arturo Bonometti, Luca Despini, Concetta Blundo, Donatella Gambini, Nicola Fusco
Noninvasive breast lesions encompass a heterogeneous group of risk indicators and nonobligate precursors of breast cancer, such as apocrine hyperplasia (AH) and columnar cell lesions (CCLs). Given the different expression of ER and ER-regulated genes in AH and CCL, these two alterations are currently considered discrete conditions. However, whether they share early biologic changes is not clear to date. Here, we sought to define the clinicopathologic and immunohistochemical features of a prospective series of combined lesions made up by CCLs and AH forming a continuum within single terminal duct-lobular units...
October 27, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/29072521/orbital-fat-regeneration-following-hormonal-treatment-of-metastatic-breast-carcinoma
#16
Ramzi M Alameddine, Audrey C Ko, Masashi Mimura, Barbara A Parker, Jonathan H Lin, Bobby S Korn, Don O Kikkawa
Enophthalmos in the setting of breast cancer metastatic to the orbit results primarily from the disease pathogenesis, or secondary to treatment effects. Orbital volume restoration and fat regeneration following endocrine treatment monotherapy has not been previously reported. A 76- year-old previously healthy female presented with progressive right enophthalmos secondary to metastatic lobular breast carcinoma. Treatment with an aromatase inhibitor (letrozole) resulted in tumor regression and orbital fat restoration with a corresponding improvement in orbital volume and enophthalmos on clinical exam...
October 26, 2017: Orbit
https://www.readbyqxmd.com/read/29070987/results-of-short-term-follow-up-in-bi-rads-3-and-4a-breast-lesions-with-a-histological-diagnosis-of-fibroadenoma-at-percutaneous-needle-biopsy
#17
Paola Clauser, Massimo Bazzocchi, Magda Marcon, Viviana Londero, Chiara Zuiani
OBJECTIVE: To evaluate the usefulness of short-term (6 months) follow-up in patients with Breast Imaging Report and Data System (BI-RADS) 3 and 4a lesions, after a diagnosis of fibroadenoma at an image-guided biopsy. PATIENTS AND METHODS: The data of 318 women with 349 biopsy-proven fibroadenomas, a 6-month follow-up, and a follow-up of ≥ 24 months were retrospectively reviewed. Information on clinical history, lesion characteristics on ultrasound (US), mammography, and magnetic resonance imaging (MRI), BI-RADS classification, and follow-up was collected...
September 2017: Breast Care
https://www.readbyqxmd.com/read/29064753/ultrasound-features-of-mammographic-developing-asymmetries-and-correlation-with-histopathologic-findings
#18
Catherine S Giess, Allyson L Chesebro, Sona A Chikarmane
OBJECTIVE: The purpose of this study is to review the ultrasound (US) features of developing asymmetries and correlate them with histopathologic findings. MATERIALS AND METHODS: We searched the mammography database of an academic medical center, affiliated cancer center, and two ambulatory imaging facilities from 2009 to 2012 and identified 201 patients with developing asymmetries, 187 of whom had US at the time of, or within 1 month of, diagnostic mammography evaluation...
October 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29058924/-magnetic-resonance-imaging-in-preoperative-diagnosis-of-invasive-lobular-carcinomas-of-the-breast-analysis-of-230-cases
#19
O Coufal, M Schneiderová, K Petráková, I Babánková, I Selingerová
INTRODUCTION: In breast cancer patients, magnetic resonance imaging (MRI) is a supportive method characterized by high sensitivity. Its indications in the preoperative assessment are not clearly defined. More likely to benefit from preoperative MRI are younger women, women with a dense breast on mammography and patients with invasive lobular carcinoma (ILC). The aim of this study was to assess utilization of MRI and resulting benefits in preoperative tumour staging of ILC in patients treated in our institution...
2017: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29055945/bladder-metastases-from-breast-cancer-managing-the-unexpected-a-systematic-review
#20
Francesca Sanguedolce, Matteo Landriscina, Antonio Ambrosi, Nicola Tartaglia, Pasquale Cianci, Marcello Di Millo, Giuseppe Carrieri, Pantaleo Bufo, Luigi Cormio
Breast cancer (BrC) has the highest incidence among females world over and it is one of the most common causes of death from cancer overall. Its high mortality is mostly due to its propensity to rapidly spread to other organs through lymphatic and blood vessels in spite of proper treatment. Bladder metastases from BrC are rare, with 50 cases having been reported in the last 60 years. This review aims to discuss some critical points regarding this uncommon condition. First, we performed a systematic review of the literature in order to draw a clinical and pathological profile of this entity...
October 20, 2017: Urologia Internationalis
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