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https://www.readbyqxmd.com/read/29783088/evaluation-of-genotoxicity-and-mutagenic-effects-of-vector-dna-nanocomplexes-in-transfected-mesenchymal-stem-cells-by-flow-cytometry
#1
Alireza Nomani, Xuguang Chen, Arash Hatefi
In recent years, there has been a great deal of interest in ex-vivo genetic modification of mesenchymal stem cells (MSCs) to meet various biomedical needs. Considering the self-renewal potential of MSCs, it is critically important to ensure that transfection vectors (gene carriers) do not induce genotoxicity because they could theoretically turn a single stem cell into a cancer-initiating cell. Unfortunately, there is currently no reliable, unbiased, and quantitative method to measure genotoxicity (micronuclei formation) of gene carriers directly in transfected MSCs...
May 18, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29782441/how-do-hearing-aid-owners-respond-to-hearing-aid-problems
#2
Rebecca J Bennett, Ariane Laplante-Lévesque, Robert H Eikelboom
BACKGROUND: Although hearing aids can improve hearing and communication, problems that arise following the acquisition of hearing aids can result in their disuse. This study aimed to gather perspectives of hearing aid owners and hearing health care clinicians about how hearing aid owners respond to problems that arise following hearing aid fitting, and then use these perspectives to generate a conceptual framework to better understand these responses. METHODS: Seventeen hearing aid owners and 21 hearing health care clinicians generated, sorted, and rated statements regarding how hearing aid owners respond to problems associated with hearing aid use...
May 18, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29782302/reasons-for-not-using-condoms-among-heterosexual-men-in-belgrade-serbia
#3
Milan Bjekić, Sandra Sipetić-Grujičić, Hristina Vlajinac, Aleksandra Nikolić
Dear Editor, Proper and consistent use of male condoms can be a highly effective method of preventing the transmission of sexually transmitted infections (STIs) and HIV (1), but this method relies on men's willingness and ability to use condoms. In the United States of America, about 20% overall and less than 50% of adults with multiple partners used a condom at last intercourse (2). In Serbia in 2013 (3), 50.0% of women and 62.5% of men aged 15-49 who had more than one partner in the past year used a condom during their last intercourse...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781460/targeting-nicotine-addiction
#4
Ellen Carr
Smoking cessation remains a high priority in oncology nursing practice. That priority gained additional visibility in 2014 when the Oncology Nursing Society (ONS) endorsed the tobacco position statement of the International Society of Nurses in Cancer Care, emphasizing the potential for nurses to reduce adult and youth tobacco use.
June 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29779509/adolescent-confidentiality-and-women-s-health-history-rationale-and-current-threats
#5
REVIEW
Naomi A Schapiro, Jayme Mejia
Adolescent access to reproductive health services, mental health services, and treatment of drug and alcohol use depends on teens' rights to consent and confidentiality in the state in which they live. This article reviews the history, current practices, and potential challenges to confidentiality, including Title X funding, questions about brain development and ability to make autonomous choices, and meaningful use practices in electronic records. Resources are provided for professional position statements and individual state regulations...
June 2018: Nursing Clinics of North America
https://www.readbyqxmd.com/read/29778388/androgen-excess-polycystic-ovary-syndrome-society-position-statement-on-depression-anxiety-quality-of-life-and-eating-disorders-in-polycystic-ovary-syndrome
#6
Anuja Dokras, Elisabeth Stener-Victorin, Bulent O Yildiz, Rong Li, Sasha Ottey, Duru Shah, Neill Epperson, Helena Teede
OBJECTIVE: To formulate clinical consensus recommendations for screening depression, anxiety, health-related quality of life (HRQoL), and disordered eating symptoms in women with polycystic ovary syndrome (PCOS) and review prevalence based on phenotypes and ethnicity, changes over time, etiology, and impact of treatment. DESIGN: Systematic reviews and preparation of position statement. SETTING: Not applicable. PATIENT(S): Women with PCOS and controls screened using validated tools...
May 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29778090/massive-pericardial-effusion-without-cardiac-tamponade-due-to-subclinical-hypothyroidism-hashimoto-s-disease
#7
Panteleimon E Papakonstantinou, Nikolaos Gourniezakis, Christos Skiadas, Alexandros Patrianakos, Achilleas Gikas
CONTEXT: Hypothyroidism is a significant cause of pericardial effusion. However, large pericardial effusions due to hypothyroidism are extremely rare. Hormone replacement therapy is the cornerstone of treatment for hypothyroidism and regular follow-up of patients after initiation of the therapy is indicated. Herein, the case of a 70-year-old woman with a massive pericardial effusion due to Hashimoto's disease is presented. ISSUES: A 70-year-old female from a rural village on the island of Crete, Greece, was admitted to our hospital due to a urinary tract infection...
May 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29777616/regenerative-endodontics-a-review
#8
REVIEW
S G Kim, M Malek, A Sigurdsson, L M Lin, B Kahler
The European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (2001) and Banchs & Trope (2004). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet rich fibrin have been utilized in regenerative endodontics. This approach has been described as a 'paradigm shift" and considered the first treatment option for immature teeth with pulp necrosis...
May 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29777347/intrauterine-hpv-transmission-a-systematic-review-of-the-literature
#9
REVIEW
Andreas Zouridis, Theodoros Kalampokas, Konstantinos Panoulis, Nicolaos Salakos, Efthimios Deligeoroglou
PURPOSE: To evaluate the percentage of intrauterine vertical human papillomavirus (HPV) transmission among HPV-positive mothers and the relative risk of intrauterine vertical HPV transmission between cesarean and vaginal delivery among HPV-positive women. METHODS: This systematic review was made according to the PRISMA statement. We searched PubMed and Scopus and the final articles were selected by two reviewers. Data from the selected articles were plotted, and the pooled percentage of antenatal vertical HPV transmission among HPV-positive mothers as well as the pooled relative risk of antenatal vertical HPV transmission between cesarean and vaginal delivery among HPV-positive women were calculated...
May 18, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29773755/expectations-do-not-alter-early-sensory-processing-during-perceptual-decision-making
#10
Nuttida Rungratsameetaweemana, Sirawaj Itthipuripat, Annalisa Salazar, John T Serences
Two factors play an important role in shaping perception: the allocation of selective attention to behaviorally relevant sensory features, and prior expectations about regularities in the environment. Signal detection theory proposes distinct roles of attention and expectation on decision-making such that attention modulates early sensory processing whereas expectation influences the selection and execution of motor responses. Challenging this classic framework, recent studies suggest that expectations about sensory regularities enhance the encoding and accumulation of sensory evidence during decision-making...
May 17, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29770061/canadian-public-health-laboratory-network-position-statement-non-culture-based-diagnostics-for-gastroenteritis-and-implications-for-public-health-investigations
#11
B Berenger, L Chui, A R Reimer, V Allen, D Alexander, M-C Domingo, D Haldane, L Hoang, P Levett, A MacKeen, D Marcino, C Sheitoyan-Pesant, G Zahariadis
As clinical laboratories transition to using culture-independent detection test (CIDT) panels for cases of acute gastroenteritis, culture of clinical specimens is becoming less common. The reduction in bacterial cultures available for public health activities is expected to hinder surveillance and outbreak response by public health laboratories at the local, provincial, national and international levels. These recommendations are intended to serve as guidelines for the implementation of CIDT panels in frontline laboratories in Canada...
December 7, 2017: Canada Communicable Disease Report, Relevé des Maladies Transmissibles Au Canada
https://www.readbyqxmd.com/read/29766700/health-policy-programs-realised-in-poland-in-2016-2017
#12
Patrycja Kurowska, Anna Królak, Wojciech Giermaziak
Background: Health Policy Program (Program Polityki Zdrowotnej – PPZ) is a state policy tool for engaging local government units into the mechanism of granting provision of health services. Authors show areas in which self-governments most often took preventive health care actions and describe legislative changes in the Act on provision of health services. Objective: The aim of the article is to quantitative and qualitative statement of PPZ prepared in Poland in 2016 and 2017, as well as presenting changing legal situation in the scope of evaluation of these projects...
2018: Roczniki Państwowego Zakładu Higieny
https://www.readbyqxmd.com/read/29766615/barriers-and-facilitators-to-smoking-cessation-in-pregnancy-and-in-the-post-partum-period-the-health-care-professionals-perspective
#13
Felix Naughton, Sarah Hopewell, Lesley Sinclair, Dorothy McCaughan, Jennifer McKell, Linda Bauld
OBJECTIVES: Health care professionals and the health care environment play a central role in protecting pregnant and post-partum women and their infants from smoking-related harms. This study aimed to better understand the health professional's perspective on how interactions between women, health care professionals, and the environment influence how smoking is managed. DESIGN: Semi-structured interviews and focus groups. METHODS: Data were from 48 health care staff involved in antenatal or post-partum care at two UK sites, including midwives, obstetricians, health visitors, GPs, pharmacists, service commissioners, and Stop Smoking Service (SSS) advisors and managers...
May 15, 2018: British Journal of Health Psychology
https://www.readbyqxmd.com/read/29766366/consensus-statement-on-the-definition-of-neurogenic-supine-hypertension-in-cardiovascular-autonomic-failure-by-the-american-autonomic-society-aas-and-the-european-federation-of-autonomic-societies-efas-endorsed-by-the-european-academy-of-neurology-ean-and-the
#14
REVIEW
Alessandra Fanciulli, Jens Jordan, Italo Biaggioni, Giovanna Calandra-Buonaura, William P Cheshire, Pietro Cortelli, Sabine Eschlboeck, Guido Grassi, Max J Hilz, Horacio Kaufmann, Heinz Lahrmann, Giuseppe Mancia, Gert Mayer, Lucy Norcliffe-Kaufmann, Anne Pavy-Le Traon, Satish R Raj, David Robertson, Isabel Rocha, Walter Struhal, Roland Thijs, Konstantinos P Tsioufis, J Gert van Dijk, Gregor K Wenning
PURPOSE: Patients suffering from cardiovascular autonomic failure often develop neurogenic supine hypertension (nSH), i.e., high blood pressure (BP) in the supine position, which falls in the upright position owing to impaired autonomic regulation. A committee was formed to reach consensus among experts on the definition and diagnosis of nSH in the context of cardiovascular autonomic failure. METHODS: As a first and preparatory step, a systematic search of PubMed-indexed literature on nSH up to January 2017 was performed...
May 15, 2018: Clinical Autonomic Research: Official Journal of the Clinical Autonomic Research Society
https://www.readbyqxmd.com/read/29766319/surgical-margin-status-and-its-impact-on-prostate-cancer-prognosis-after-radical-prostatectomy-a-meta-analysis
#15
Lijin Zhang, Bin Wu, Zhenlei Zha, Hu Zhao, Jun Yuan, Yuefang Jiang, Wei Yang
BACKGROUND AND PURPOSE: Positive surgical margins (PSMs) correlate with adverse outcomes in numerous solid tumours. However, the prognostic value of PSMs in prostate cancer (PCa) patients who underwent radical prostatectomy remains unclear. Herein, we performed a meta-analysis to evaluate the association between PSMs and the prognostic value for biochemical recurrence-free survival (BRFS), cancer-specific survival (CSS), overall survival (OS), cancer-specific mortality (CSM) and overall mortality (OM) in PCa patients...
May 15, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29765260/attitude-and-perception-of-undergraduate-medical-students-toward-the-problem-based-learning-in-chitwan-medical-college-nepal
#16
Ram Lochan Yadav, Rano Mal Piryani, Gopendra Prasad Deo, Dev Kumar Shah, Laxmi Kumari Yadav, Md Nazrul Islam
Background: Problem-based learning (PBL) was introduced into Basic Medical Sciences early in the 1980s at Tribhuvan University (TU), Nepal, followed by other universities where didactic lecture method was still followed as the main teaching strategy. Despite gaining its popularity worldwide as integrated teaching learning method, PBL is not given importance in Nepal. This study aimed to assess the attitude and perceptions of undergraduate medical students regarding learning outcomes of PBL and to know their views about role and qualities of effective tutors for its successful implementation...
2018: Advances in Medical Education and Practice
https://www.readbyqxmd.com/read/29764782/eaono-position-statement-on-vestibular-schwannoma-imaging-assessment-what-are-the-indications-for-performing-a-screening-mri-scan-for-a-potential-vestibular-schwannoma
#17
Jérôme Waterval, Romain Kania, Thomas Somers
No abstract text is available yet for this article.
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29764781/eaono-position-statement-on-vestibular-schwannoma-imaging-assessment-question-how-should-growth-of-vestibular-schwannoma-be-defined
#18
Romain Kania, Benjamin Vérillaud, Domitille Camous, Charlotte Hautefort, Thomas Somers, Jérôme Waterval, Sébastien Froelich, Philippe Herman
The relevance of defining the growth of vestibular schwannoma (VS) is that any significant VS growth may impact treatment strategy. A conservative treatment strategy is often proposed as a primary treatment option in the management of VS. Several authors have demonstrated that a significant proportion of VSs do not grow, and those that do, usually grow slowly. Surgical and/or radiosurgical treatment options may be offered to the patient according to the VS growth. Therefore, defining the VS growth is a determinant in managing treatment strategies...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29764780/what-is-the-required-frequency-of-mri-scanning-in-the-wait-and-scan-management
#19
Thomas Somers, Romain Kania, Jerome Waterval, Tony Van Havenbergh
The wait and scan policy is being increasingly used as the first measure after the diagnosis of a vestibular schwannoma (VS) using magnetic resonance imaging (MRI). As part of the European Academy of Otology and Neuro-Otology (EAONO) position statement on VS, the frequency of imaging has been studied in the literature. Among 163 studies, 29 fulfilled the inclusion criteria and were scored using the Grading of Recommendations, Assessment, Development, and Evaluation system. Because tumor growth rate during the first 5 years of follow-up is predictive of further growth during the upcoming years, a protocol for wait and scan is useful for centers dealing with this condition...
April 2018: Journal of International Advanced Otology
https://www.readbyqxmd.com/read/29763369/adipose-y5r-mrna-is-higher-in-obese-than-non-obese-humans-and-is-correlated-with-obesity-parameters
#20
Saimai Chatree, Chantacha Sitticharoon, Pailin Maikaew, Panapat Uawithya, Supornpim Chearskul
Neuropeptide Y is mainly expressed in the central nervous system to regulate food intake via its receptors, Y receptors, and in various peripheral tissues including adipose tissue. The objectives of this study were to compare Y5R mRNA and adipocyte parameters consisting of area, width, height, and perimeter either between obese and non-obese subjects or between subcutaneous and visceral fat as well as to compare between NPY, Y1R, Y2R, and Y5R mRNA expressions in subcutaneous and visceral adipose tissues. In subcutaneous and visceral adipose tissues, Y5R was greater in obese than in non-obese humans (both P < 0...
May 2018: Experimental Biology and Medicine
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