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https://www.readbyqxmd.com/read/28334978/therapeutic-window-of-dopamine-d2-3-receptor-occupancy-to-treat-psychosis-in-alzheimer-s-disease
#1
Suzanne Reeves, Emma McLachlan, Julie Bertrand, Fabrizia D Antonio, Stuart Brownings, Akshay Nair, Suki Greaves, Alan Smith, David Taylor, Joel Dunn, Paul Marsden, Robert Kessler, Robert Howard
Antipsychotic drugs, originally developed to treat schizophrenia, are used to treat psychosis, agitation and aggression in Alzheimer's disease. In the absence of dopamine D2/3 receptor occupancy data to inform antipsychotic prescribing for psychosis in Alzheimer's disease, the mechanisms underpinning antipsychotic efficacy and side effects are poorly understood. This study used a population approach to investigate the relationship between amisulpride blood concentration and central D2/3 occupancy in older people with Alzheimer's disease by combining: (i) pharmacokinetic data (280 venous samples) from a phase I single (50 mg) dose study in healthy older people (n = 20, 65-79 years); (ii) pharmacokinetic, 18F-fallypride D2/3 receptor imaging and clinical outcome data on patients with Alzheimer's disease who were prescribed amisulpride (25-75 mg daily) to treat psychosis as part of an open study (n = 28; 69-92 years; 41 blood samples, five pretreatment scans, 19 post-treatment scans); and (iii) 18F-fallypride imaging of an antipsychotic free Alzheimer's disease control group (n = 10, 78-92 years), to provide additional pretreatment data...
February 4, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28319837/kalirin-reduction-rescues-psychosis-associated-behavioral-deficits-in-appswe-psen1de9-transgenic-mice
#2
Josh M Krivinko, Susan L Erickson, Eric E Abrahamson, Zachary P Wills, Milos D Ikonomovic, Peter Penzes, Robert A Sweet
Psychosis in Alzheimer's disease (AD+P) represents a distinct clinical and neurobiological AD phenotype and is associated with more rapid cognitive decline, higher rates of abnormal behaviors, and increased caregiver burden compared with AD without psychosis. On a molecular level, AD+P is associated with greater reductions in the protein kalirin, a guanine exchange factor which has also been linked to the psychotic disease, schizophrenia. In this study, we sought to determine the molecular and behavioral consequences of kalirin reduction in APPswe/PSEN1dE9 mice...
February 16, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28238739/consensus-based-recommendations-for-the-management-of-rapid-cognitive-decline-due-to-alzheimer-s-disease
#3
Jianping Jia, Serge Gauthier, Sarah Pallotta, Yong Ji, Wenshi Wei, Shifu Xiao, Dantao Peng, Qihao Guo, Liyong Wu, Shengdi Chen, Weihong Kuang, Junjian Zhang, Cuibai Wei, Yi Tang
INTRODUCTION: Rapid cognitive decline (RCD) occurs in dementia due to Alzheimer's disease (AD). METHODS: Literature review, consensus meetings, and a retrospective chart review of patients with probable AD were conducted. RESULTS: Literature review showed that RCD definitions varied. Mini-Mental State Examination scores <20 at treatment onset, vascular risk factors, age <70 years at symptom onset, higher education levels, and early appearance of hallucinations, psychosis, or extrapyramidal symptoms are recognized RCD risk factors...
February 24, 2017: Alzheimer's & Dementia: the Journal of the Alzheimer's Association
https://www.readbyqxmd.com/read/28222514/one-year-evolution-of-behavioral-and%C3%A2-psychological-symptoms-of-dementia-in-patients-initially-hospitalized-in%C3%A2-cognitive-behavioral-units-the-evital-prospective-cohort
#4
Isabelle Rouch, Elodie Pongan, Béatrice Trombert, Florence Fabre, Nicolas Auguste, Claire Sellier, Magalie Freulon, Sophie Jacqueline, Denis Federico, Christelle Mouchoux, Géraldine Martin-Gaujard, Pierre Krolak-Salmon, Bernard Laurent, Jean-Michel Dorey
BACKGROUND: The 2008-2012 French Alzheimer's Plan has provided hospital Cognitive and Behavioral Units (CBU) to improve the management of patients with productive behavioral and psychological symptoms of dementia (BPSD). Little is known concerning the behavioral outcome of these patients after discharge. OBJECTIVE: The present study investigated the long-term evolution of BPSD over one year after CBU discharge. METHODS: The EVITAL cohort included 221 participants admitted to the CBUs of 3 French hospitals...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28219318/gender-and-pathology-specific-effect-of-apolipoprotein-e-genotype-on-psychosis-in-alzheimer-s-disease
#5
Julia Kim, Corinne E Fischer, Tom A Schweizer, David G Munoz
BACKGROUND: Symptoms of psychosis is one of the common clinical manifestations of Alzheimer's disease (AD). However, the pathophysiology behind psychosis is unknown. OBJECTIVE: The aim of the present study was to explore the relationship between Apolipoprotein E (APOE) genotype, Lewy body pathology, and psychosis in AD. METHODS: The data was obtained from the National Alzheimer's disease Coordinating Centre (NACC), using the Uniform Data Set and the Neuropathology Data Set...
February 20, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/27911311/risk-factors-and-pathological-substrates-associated-with-agitation-aggression-in-alzheimer-s-disease-a-preliminary-study-using-nacc-data
#6
Simrin Sennik, Tom A Schweizer, Corinne E Fischer, David G Munoz
BACKGROUND: Neuropsychiatric symptoms are common manifestations of Alzheimer's disease (AD). A number of studies have targeted psychosis, i.e., hallucinations and delusions in AD, but few have assessed agitation/aggression in AD. OBJECTIVE: To investigate the risk factors and pathological substrates associated with presence [A(+)] and absence [A(-)] of agitation/aggression (A) in autopsy-confirmed AD. METHODS: Data was collected from the UDS data as of 2015 on the NACC database...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27855483/prediction-of-relapse-after-discontinuation-of-antipsychotic-treatment-in-alzheimer-s-disease-the-role-of-hallucinations
#7
Anjali N Patel, Seonjoo Lee, Howard F Andrews, Gregory H Pelton, Susan K Schultz, David L Sultzer, Jacobo Mintzer, Danilo de la Pena, Sanjay Gupta, Sylvia Colon, Corbett Schimming, Bruce Levin, D P Devanand
OBJECTIVE: In Alzheimer's disease, antipsychotic medications are often used for a period, with relief of symptoms, and then discontinued, after which relapse may occur. The authors sought to determine which neuropsychiatric symptoms predict relapse. METHOD: In the Antipsychotic Discontinuation in Alzheimer's Disease trial, 180 patients with Alzheimer's disease and symptoms of agitation or psychosis were treated with risperidone for 16 weeks, after which patients who responded (N=110) were randomly assigned to continue risperidone for 32 weeks, to continue risperidone for 16 weeks followed by switch to placebo for 16 weeks, or to receive placebo for 32 weeks...
November 18, 2016: American Journal of Psychiatry
https://www.readbyqxmd.com/read/27819842/low-dose-lithium-treatment-for-agitation-and-psychosis-in-alzheimer-disease-and-frontotemporal-dementia-a-case-series
#8
Davangere P Devanand, Gregory H Pelton, Kristina D'Antonio, Jesse G Strickler, William C Kreisl, James Noble, Karen Marder, Anne Skomorowsky, Edward D Huey
No abstract text is available yet for this article.
January 2017: Alzheimer Disease and Associated Disorders
https://www.readbyqxmd.com/read/27789118/adverse-structural-and-functional-effects-of-marijuana-on-the-brain-evidence-reviewed
#9
REVIEW
David E Mandelbaum, Suzanne M de la Monte
The growing use and legalization of cannabis are leading to increased exposures across all age groups, including in adolescence. The touting of its medicinal values stems from anecdotal reports related to treatment of a broad range of illnesses including epilepsy, multiple sclerosis, muscle spasms, arthritis, obesity, cancer, Alzheimer disease, Parkinson disease, post-traumatic stress, inflammatory bowel disease, and anxiety. However, anecdotal data and the high level of interest in this treatment must not obscure objective assessments of any potential and realized short- and long-term adverse effects of cannabis, particularly with respect to age of onset and chronicity of exposure...
January 2017: Pediatric Neurology
https://www.readbyqxmd.com/read/27714849/psychosocial-or-clinico-demographic-factors-related-to-neuropsychiatric-symptoms-in-patients-with-alzheimer-s-disease-needing-interventional-treatment-analysis-of-the-catie-ad-study
#10
Tomoyuki Nagata, Shinichiro Nakajima, Shunichiro Shinagawa, Eric Plitman, Ariel Graff-Guerrero, Masaru Mimura, Kazuhiko Nakayama
OBJECTIVE: This study sought to determine psychosocial and clinico-demographic factors related to each symptomatic cluster (i.e., aggressiveness, psychosis, apathy/eating problems, and emotion/disinhibition) of neuropsychiatric symptoms (NPSs) in patients with Alzheimer's disease (AD) needing interventional treatment against their agitation or psychotic symptoms. These clusters were classified from 12 Neuropsychiatric Inventory (NPI) subscores in our previous study using the Clinical Antipsychotic Trials of Intervention Effectiveness-Alzheimer's Disease (CATIE-AD) dataset...
October 7, 2016: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/27662301/the-role-of-cerebrovascular-disease-on-cognitive-and-functional-status-and-psychosis-in-severe-alzheimer-s-disease
#11
Julia Kim, Tom A Schweizer, Corinne E Fischer, David G Munoz
BACKGROUND: The pathophysiology behind psychosis in patients with Alzheimer's disease (AD) remains unknown. Recently, vascular risk factors have been recognized as important modifiers of the clinical presentation of AD. OBJECTIVE: The purpose of our study is to investigate the mechanism through which vascular risk factors mediate psychosis and whether or not it involves cerebrovascular lesions. METHODS: Data was provided by the National Alzheimer's Coordinating Centre...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27632159/neuropsychiatric-symptom-clusters-in-stroke-and-transient-ischemic-attack-by-cognitive-status-and-stroke-subtype-frequency-and-relationships-with-vascular-lesions-brain-atrophy-and-amyloid
#12
Adrian Wong, Alexander Y L Lau, Jie Yang, Zhaolu Wang, Wenyan Liu, Bonnie Y K Lam, Lisa Au, Lin Shi, Defeng Wang, Winnie C W Chu, Yun-Yun Xiong, Eugene S K Lo, Lorraine S N Law, Thomas W H Leung, Linda C W Lam, Anne Y Y Chan, Yannie O Y Soo, Eric Y L Leung, Lawrence K S Wong, Vincent C T Mok
BACKGROUND: The objectives of this study are 1) to examine the frequencies of neuropsychiatric symptom clusters in patients with stroke or transient ischemic attack (TIA) by cognitive level and stroke subtype; and 2) to evaluate effect of demographic, clinical, and neuroimaging measures of chronic brain changes and amyloid upon neuropsychiatric symptom clusters. METHODS: Hospital-based, cross-sectional study. 518 patients were administered the Neuropsychiatric Inventory (NPI) 3-6 months post index admission...
2016: PloS One
https://www.readbyqxmd.com/read/27592250/ligand-autoradiographical-quantification-of-histamine-h3-receptor-in-human-dementia-with-lewy-bodies
#13
Natasha L Lethbridge, Paul L Chazot
Dementia with Lewy bodies (DLB) is a serious age-dependent human neurodegenerative disease, with multiple debilitating symptoms, including dementia, psychosis and significant motor deficits, but with little or no effective treatments. This comparative ligand autoradiographical study has quantified histamine H3 receptors (H3R) in a series of major cortical and basal ganglia structures in human DLB and Alzheimer's (AD) post-mortem cases using the highly selective radioligand, [(3)H] GSK189254. In the main, the levels of H3 receptor were largely preserved in DLB cases when compared with aged-matched controls...
August 31, 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27583123/antipsychotic-use-in-dementia-a-systematic-review-of-benefits-and-risks-from-meta-analyses
#14
Rajesh R Tampi, Deena J Tampi, Silpa Balachandran, Shilpa Srinivasan
BACKGROUND: The purpose of this review is to evaluate the data on the use of antipsychotics in individuals with dementia from meta-analyses. METHODS: We performed a literature search of PubMed, MEDLINE, EMBASE, PsycINFO and Cochrane collaboration databases through 30 November, 2015 using the following keywords: 'antipsychotics', 'dementia' and 'meta-analysis'. The search was not restricted by the age of the patients or the language of the study. However, in the final analysis we only included studies involving patients that were published in English language journals or had official English translations...
September 2016: Therapeutic Advances in Chronic Disease
https://www.readbyqxmd.com/read/27567807/a-decade-of-cerebrospinal-fluid-biomarkers-for-alzheimer-s-disease-in-belgium
#15
Charisse Somers, Hanne Struyfs, Joery Goossens, Ellis Niemantsverdriet, Jill Luyckx, Naomi De Roeck, Ellen De Roeck, Bart De Vil, Patrick Cras, Jean-Jacques Martin, Peter-Paul De Deyn, Maria Bjerke, Sebastiaan Engelborghs
During the past ten years, over 5,000 cerebrospinal fluid (CSF) samples were analyzed at the Reference Center for Biological Markers of Dementia (BIODEM), UAntwerp, for core Alzheimer's disease (AD) CSF biomarkers: amyloid-β peptide of 42 amino acids (Aβ1-42), total tau protein (T-tau), and tau phosphorylated at threonine 181 (P-tau181P). CSF biomarker analyses were performed using single-analyte ELISA kits. In-house validated cutoff values were applied: Aβ1-42 <638.5 pg/mL, T-tau >296.5 pg/mL, P-tau181P >56...
August 10, 2016: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/27561138/a-systematic-review-of-the-evidence-for-medical-marijuana-in-psychiatric-indications
#16
Samuel T Wilkinson, Rajiv Radhakrishnan, Deepak Cyril D'Souza
OBJECTIVE: Marijuana has been approved for a number of psychiatric conditions in many states in the US including posttraumatic stress disorder (PTSD), agitation in Alzheimer's disease, and Tourette's disorder. In this systematic review, we examine the strength of evidence for the efficacy of marijuana and other cannabinoids for these psychiatric indications. DATA SOURCES: The literature (MEDLINE) was searched for studies published between January 1980 and March 2015 using search terms related to marijuana and other cannabinoids and the specific diagnosis...
August 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/27502299/revisiting-dlb-diagnosis-a-consideration-of-prodromal-dlb-and-of-the-diagnostic-overlap-with-alzheimer-disease
#17
Ian McKeith, John-Paul Taylor, Alan Thomas, Paul Donaghy, Joseph Kane
Efforts to clinically diagnose cases having dementia with Lewy bodies (DLB) identify those with a characteristic clinical syndrome (probable DLB) at the expense of missing an equal, if not greater, number of cases who have atypical presentations thought to be associated with coexisting Alzheimer pathologies. This article argues that further efforts should now be made to characterize this atypical group that constitutes cases previously identified postmortem as the Lewy body variant of Alzheimer disease (AD) or as AD with Lewy bodies...
September 2016: Journal of Geriatric Psychiatry and Neurology
https://www.readbyqxmd.com/read/27497990/polymorphisms-of-dopamine-receptor-genes-and-risk-of-visual-hallucinations-in-parkinson-s-patients
#18
M Ferrari, C Comi, F Marino, L Magistrelli, F De Marchi, R Cantello, G Riboldazzi, G Bono, M Cosentino
BACKGROUND: Visual hallucinations (VHs) are frequent non-motor complication of Parkinson's disease (PD), associated to a negative prognosis. Previous studies showed an association between dopamine receptor (DR) gene (DR) variants and psychosis in Alzheimer's disease, addictions, schizophrenia, and bipolar disorder. However, there are only a few studies on DR variants and VHs in PD, which did not provide conclusive results. OBJECTIVES: The present study aimed to determine whether genetic differences of DR are associated with visual hallucinations (VHs) in a cohort of Parkinson's disease (PD) patients...
November 2016: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27490935/conjoint-ftld-fus-of-the-neuronal-intermediate-filament-inclusion-disease-type-progressive-supranuclear-palsy-and-alzheimer-s-pathology-presenting-as-parkinsonism-with-early-falls-and-late-hallucinations-psychosis-and-dementia
#19
Yaroslau Compta, Oscar Ramos-Campoy, Oriol Grau-Rivera, Martí Colom-Cadena, Jordi Clarimón, María José Martí, Ellen Gelpi
Progressive supranuclear palsy (PSP) is a low-prevalence atypical parkinsonism with underlying 4R-tauopathy and a growing number of clinical phenotypes, making its differential diagnosis from other conditions such as Parkinson's disease (PD) and corticobasal degeneration particularly challenging (1,2). Neuronal intermediate filament inclusion disease (NIFID), a sporadic alpha-internexin and fused-in-sarcoma (FUS) proteinopathy, is an even rarer condition with few cases published worldwide. It is most often diagnosed at autopsy, again due to a remarkable clinical heterogeneity ranging from young-onset frontotemporal dementia to PSP-lookalike parkinsonism, among other phenotypes (3-6)...
August 4, 2016: Neuropathology and Applied Neurobiology
https://www.readbyqxmd.com/read/27486386/manual-protocol-inspired-technique-for-improving-automated-mr-image-segmentation-during-label-fusion
#20
Nikhil Bhagwat, Jon Pipitone, Julie L Winterburn, Ting Guo, Emma G Duerden, Aristotle N Voineskos, Martin Lepage, Steven P Miller, Jens C Pruessner, M Mallar Chakravarty
Recent advances in multi-atlas based algorithms address many of the previous limitations in model-based and probabilistic segmentation methods. However, at the label fusion stage, a majority of algorithms focus primarily on optimizing weight-maps associated with the atlas library based on a theoretical objective function that approximates the segmentation error. In contrast, we propose a novel method-Autocorrecting Walks over Localized Markov Random Fields (AWoL-MRF)-that aims at mimicking the sequential process of manual segmentation, which is the gold-standard for virtually all the segmentation methods...
2016: Frontiers in Neuroscience
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