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British journal of surgery

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https://www.readbyqxmd.com/read/28934761/comparison-between-mri-and-pathology-in-the-assessment-of-tumour-regression-grade-in-rectal-cancer
#1
Francesco Sclafani, Gina Brown, David Cunningham, Andrew Wotherspoon, Larissa Sena Teixeira Mendes, Svetlana Balyasnikova, Jessica Evans, Clare Peckitt, Ruwaida Begum, Diana Tait, Josep Tabernero, Bengt Glimelius, Susana Roselló, Janet Thomas, Jacqui Oates, Ian Chau
BACKGROUND: Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. METHODS: mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). The agreement between radiologist and pathologist was assessed with the weighted κ test while the Kaplan-Meier method was used to estimate survival outcomes. RESULTS: One hundred ninety-one patients were included...
September 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28859058/preoperative-chemoradiation-with-capecitabine-irinotecan-and-cetuximab-in-rectal-cancer-significance-of-pre-treatment-and-post-resection-ras-mutations
#2
Simon Gollins, Nick West, David Sebag-Montefiore, Arthur Sun Myint, Mark Saunders, Shabbir Susnerwala, Phil Quirke, Sharadah Essapen, Leslie Samuel, Bruce Sizer, Jane Worlding, Katie Southward, Gemma Hemmings, Emma Tinkler-Hundal, Morag Taylor, Daniel Bottomley, Philip Chambers, Emma Lawrie, Andre Lopes, Sandy Beare
BACKGROUND: The influence of EGFR pathway mutations on cetuximab-containing rectal cancer preoperative chemoradiation (CRT) is uncertain. METHODS: In a prospective phase II trial (EXCITE), patients with magnetic resonance imaging (MRI)-defined non-metastatic rectal adenocarinoma threatening/involving the surgical resection plane received pelvic radiotherapy with concurrent capecitabine, irinotecan and cetuximab. Resection was recommended 8 weeks later. The primary endpoint was histopathologically clear (R0) resection margin...
August 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28797032/comprehensive-geriatric-assessment-in-326-older-women-with-early-breast-cancer
#3
D O Okonji, R Sinha, I Phillips, D Fatz, A Ring
BACKGROUND: One-third of new early breast cancer diagnoses occur in women over 70 years old. However, older women are less likely to receive radical curative treatments. This study prospectively evaluated a cohort of older women using a Comprehensive Geriatric Assessment (CGA) to determine whether fitness explained the apparent under-treatment in this patient group. METHODS: In this multi-centre prospective study, patients aged ⩾70 years with Stages I-III breast cancer underwent a pretreatment baseline CGA consisting of eight assessment tools...
August 10, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28728167/long-term-outcomes-of-patients-with-10-or-more-colorectal-liver-metastases
#4
MULTICENTER STUDY
M A Allard, R Adam, F Giuliante, R Lapointe, C Hubert, J N M Ijzermans, D F Mirza, D Elias, C Laurent, T Gruenberger, G Poston, C Letoublon, H Isoniemi, V Lucidi, I Popescu, J Figueras
BACKGROUND: Although the number of colorectal liver metastases (CLM) is decreasingly considered as a contraindication to surgery, patients with 10 CLM or more are often denied liver surgery. This study aimed to evaluate the outcome after liver surgery and to identify prognostic factors of survival in such patients. METHODS: The study population consisted of a multicentre cohort of patients with CLM (N=12 406) operated on, with intention to resect, from January 2005-June 2013 and whose data were prospectively collected in the LiverMetSurvey registry...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28728163/nuclear-expression-of-gli-1-is-predictive-of-pathologic-complete-response-to-chemoradiation-in-trimodality-treated-oesophageal-cancer-patients
#5
Roopma Wadhwa, Xuemei Wang, Veerabhadran Baladandayuthapani, Bin Liu, Hironori Shiozaki, Yusuke Shimodaira, Quan Lin, Elena Elimova, Wayne L Hofstetter, Stephen G Swisher, David C Rice, Dipen M Maru, Neda Kalhor, Manoop S Bhutani, Brian Weston, Jeffrey H Lee, Heath D Skinner, Ailing W Scott, Dilsa Mizrak Kaya, Kazuto Harada, Donald Berry, Shumei Song, Jaffer A Ajani
BACKGROUND: Predictive biomarkers or signature(s) for oesophageal cancer (OC) patients undergoing preoperative therapy could help administration of effective therapy, avoidance of ineffective ones, and establishment new strategies. Since the hedgehog pathway is often upregulated in OC, we examined its transcriptional factor, Gli-1, which confers therapy resistance, we wanted to assess Gli-1 as a predictive biomarker for chemoradiation response and validate it. METHODS: Untreated OC tissues from patients who underwent chemoradiation and surgery were assessed for nuclear Gli-1 by immunohistochemistry and labelling indices (LIs) were correlated with pathologic complete response (pathCR) or <pathCR (resistance) and validated in a unique cohort...
August 22, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28716796/clinical-and-cost-effectiveness-of-progressive-exercise-compared-with-best-practice-advice-with-or-without-corticosteroid-injection-for-the-treatment-of-rotator-cuff-disorders-protocol-for-a-2x2-factorial-randomised-controlled-trial-the-grasp-trial
#6
Sally Hopewell, David J Keene, Michael Maia Schlüssel, Melina Dritsaki, Susan Dutton, Andrew Carr, William Hamilton, Zara Hansen, Anju Jaggi, Chris Littlewood, Hessam Soutakbar, Peter Heine, Lucy Cureton, Karen Barker, Sarah E Lamb
INTRODUCTION: Shoulder pain is very common, with around 70% of cases due to disorders of the rotator cuff. Despite widespread provision of physiotherapy, there is uncertainty about which type of exercise and delivery mechanisms are associated with best outcomes. There is also uncertainty around the long-term benefits and harms of corticosteroid injection therapy, which is often used in addition to physiotherapy. The Getting it Right: Addressing Shoulder Pain trial will assess the clinical and cost-effectiveness of individually tailored, progressive exercise compared with best practice advice, with or without corticosteroid injection, in adults with a rotator cuff disorder...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28689892/corrigendum-to-aetiology-pathogenesis-and-specific-management-of-stahl-s-ear-role-of-the-transverse-muscle-insertion-british-journal-of-oral-and-maxillofacial-surgery-51-8-2013-e230-233
#7
A Gleizal, R Viard, J T Bachelet
No abstract text is available yet for this article.
September 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28683471/non-invasive-prediction-of-recurrence-in-bladder-cancer-by-detecting-somatic-tert-promoter-mutations-in-urine
#8
COMPARATIVE STUDY
Françoise Descotes, Norelyakin Kara, Myriam Decaussin-Petrucci, Eric Piaton, Florence Geiguer, Claire Rodriguez-Lafrasse, Jean E Terrier, Jonathan Lopez, Alain Ruffion
BACKGROUND: Urothelial bladder cancer (UBC) is characterised by a high risk of recurrence. Patient monitoring is currently based on iterative cystoscopy and on urine cytology with low sensitivity in non-muscle-invasive bladder cancer (NMIBC). Telomerase reverse transcriptase (TERT) is frequently reactivated in UBC by promoter mutations. METHODS: We studied whether detection of TERT mutation in urine could be a predictor of UBC recurrence and compared this to cytology/cystoscopy for patient follow-up...
August 8, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28662046/a-prospective-study-on-an-innovative-online-forum-for-peer-reviewing-of-surgical-science
#9
Martin Almquist, Regula S von Allmen, Dan Carradice, Steven J Oosterling, Kirsty McFarlane, Bas Wijnhoven
BACKGROUND: Peer review is important to the scientific process. However, the present system has been criticised and accused of bias, lack of transparency, failure to detect significant breakthrough and error. At the British Journal of Surgery (BJS), after surveying authors' and reviewers' opinions on peer review, we piloted an open online forum with the aim of improving the peer review process. METHODS: In December 2014, a web-based survey assessing attitudes towards open online review was sent to reviewers with a BJS account in Scholar One...
2017: PloS One
https://www.readbyqxmd.com/read/28632724/oral-squamous-cell-carcinoma-patients-can-be-differentiated-from-healthy-individuals-with-label-free-serum-proteomics
#10
Mayank Saraswat, Antti Mäkitie, Rahul Agarwal, Sakari Joenväärä, Suvi Renkonen
BACKGROUND: No blood biomarkers to detect early oral cavity squamous cell carcinoma (OSCC) without clinical signs exist - diagnosis is solely based on histology of a visible tumour. Most OSCC patients are diagnosed at advanced stage, which leads to significant morbidity and poor survival. Our aim was to find the serum screening or detection biomarkers in OSCC. METHODS: Serum samples from patients with OSCC treated at the Department of Otorhinolaryngology - Head and Neck Surgery, Helsinki University Hospital (Finland) were collected...
July 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28588320/the-influence-of-timing-of-radiation-therapy-following-breast-conserving-surgery-on-10-year-disease-free-survival
#11
Marissa C van Maaren, Reini W Bretveld, Jan J Jobsen, Renske K Veenstra, Catharina Gm Groothuis-Oudshoorn, Hendrik Struikmans, John H Maduro, Luc Ja Strobbe, Philip Mp Poortmans, Sabine Siesling
BACKGROUND: The Dutch guidelines advise to start radiation therapy (RT) within 5 weeks following breast-conserving surgery (BCS). However, much controversy exists regarding timing of RT. This study investigated its effect on 10-year disease-free survival (DFS) in a Dutch population-based cohort. METHODS: All women diagnosed with primary invasive stage I-IIIA breast cancer in 2003 treated with BCS+RT were included. Two populations were studied. Population 1 excluded patients receiving chemotherapy before RT...
July 11, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28524161/efficacy-of-anti-pd-1-therapy-in-patients-with-melanoma-brain-metastases
#12
Sagun Parakh, John J Park, Shehara Mendis, Rajat Rai, Wen Xu, Serigne Lo, Martin Drummond, Catherine Rowe, Annie Wong, Grant McArthur, Andrew Haydon, Miles C Andrews, Jonathan Cebon, Alex Guminski, Richard F Kefford, Georgina V Long, Alexander M Menzies, Oliver Klein, Matteo S Carlino
BACKGROUND: There is limited data on the efficacy of anti-programmed death 1 (PD-1) antibodies in patients (pts) with melanoma brain metastasis (BM), particularly those which are symptomatic. METHOD: We retrospectively assessed pts with melanoma BM treated with PD-1 antibodies, nivolumab and pembrolizumab. Clinicopathologic and treatment parameters were collected and outcomes determined for intracranial (IC) response rate (RR) using a modified RECIST criteria, with up to five IC target lesions used to determine IC response, disease control rate (DCR) and progression-free survival (PFS)...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28472822/human-papillomavirus-association-is-the-most-important-predictor-for-surgically-treated-patients-with-oropharyngeal-cancer
#13
Steffen Wagner, Claus Wittekindt, Shachi Jenny Sharma, Nora Wuerdemann, Theresa Jüttner, Miriam Reuschenbach, Elena-Sophie Prigge, Magnus von Knebel Doeberitz, Stefan Gattenlöhner, Ernst Burkhardt, Jörn Pons-Kühnemann, Jens Peter Klussmann
BACKGROUND: Upfront surgery is a valuable treatment option for oropharyngeal squamous cell carcinoma (OPSCC) and risk stratification is emerging for treatment de-escalation in human papillomavirus (HPV)-related OPSCC. Available prognostic models are either based on selected, mainly non-surgically treated cohorts. Therefore, we investigated unselected OPSCC treated with predominantly upfront surgery. METHODS: All patients diagnosed with OPSCC and treated with curative intent between 2000 and 2009 (n=359) were included...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28449006/a-meta-analysis-comparing-the-risk-of-metastases-in-patients-with-rectal-cancer-and-mri-detected-extramural-vascular-invasion-mremvi-vs-mremvi-negative-cases
#14
REVIEW
Muhammed R S Siddiqui, Constantinos Simillis, Chris Hunter, Manish Chand, Jemma Bhoday, Aurelie Garant, Te Vuong, Giovanni Artho, Shahnawaz Rasheed, Paris Tekkis, Al-Mutaz Abulafi, Gina Brown
BACKGROUND: Pathological extramural vascular invasion (EMVI) is an independent prognostic factor in rectal cancer, but can also be identified on MRI-detected extramural vascular invasion (mrEMVI). We perform a meta-analysis to determine the risk of metastatic disease at presentation and after surgery in mrEMVI-positive patients compared with negative tumours. METHODS: Electronic databases were searched from January 1980 to March 2016. Conventional meta-analytical techniques were used to provide a summative outcome...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28441385/preoperative-clinical-pathway-of-breast-cancer-patients-determinants-of-compliance-with-eusoma-quality-indicators
#15
MULTICENTER STUDY
Delphine Héquet, Cyrille Huchon, Sandrine Baffert, Séverine Alran, Fabien Reyal, Thuy Nguyen, Alix Combes, Caroline Trichot, Karine Alves, Hélène Berseneff, Roman Rouzier
BACKGROUND: The European Society of Breast Cancer Specialists (EUSOMA) has defined quality indicators for breast cancer (BC). The aim of this study was to describe the preoperative clinical pathway of breast cancer patients and evaluate the determinants of compliance with EUSOMA quality indicators in the Optisoins01 cohort. METHODS: Optisoins01 is a prospective, multicentric study. Data from operable BC patients were collected, including results from before surgery to 1 year follow-up...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28372883/how-far-reaching-is-our-research-an-analysis-of-the-journals-in-which-oral-and-maxillofacial-surgery-research-is-cited
#16
A Tahim, S Hilmi, S Holmes
In this study we investigate the five most cited articles in the British Journal of Oral and Maxillofacial Surgery (BJOMS). Articles cited were usually published in other OMFS journals (40%) or dentistry journals (32%). The mean (SD) SCImago Journal and Country Rank, (SJR) (an interface to access the bibliometric database of journals) for cited papers was 0.64 (SD=0.56). Nearly one third of citations were of research in OMFS and dentistry, suggesting its relevance to the wider academic community.
March 31, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28359544/corrigendum-to-effect-of-platelet-rich-plasma-in-alveolar-distraction-osteogenesis-a-controlled-clinical-trial-british-journal-of-oral-and-maxillofacial-surgery-54-1-2016-83-87
#17
Diogo J B Menezes, Jamil Awad Shibli, Sergio Alexandre Gehrke, Andréa M Beder, Wilson R Sendyk
No abstract text is available yet for this article.
May 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28350786/methylation-of-mylk3-gene-promoter-region-a-biomarker-to-stratify-surgical-care-in-ovarian-cancer-in-a-multicentre-study
#18
MULTICENTER STUDY
David L Phelps, Jane V Borley, Kirsty J Flower, Roberto Dina, Silvia Darb-Esfahani, Ioana Braicu, Jalid Sehouli, Christina Fotopoulou, Charlotte S Wilhelm-Benartzi, Hani Gabra, Joseph Yazbek, Jayanta Chatterjee, Jacey Ip, Harun Khan, Marina-Therese Likos-Corbett, Robert Brown, Sadaf Ghaem-Maghami
BACKGROUND: Survival benefit from surgical debulking of ovarian cancer (OC) is well established, but some women, despite total macroscopic clearance of disease, still have poor prognosis. We aimed to identify biomarkers to predict benefit from conventional surgery. METHODS: Clinical data from women debulked for high-stage OC were analysed (Hammersmith Hospital, London, UK; 2001-2014). Infinium's HumanMethylation27 array interrogated tumour DNA for differentially methylated CpG sites, correlated to survival, in patients with the least residual disease (RD; Hammersmith Array)...
May 9, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28334729/slug-transcription-factor-a-pro-survival-and-prognostic-factor-in-gastrointestinal-stromal-tumour
#19
Olli-Pekka Pulkka, Bengt Nilsson, Maarit Sarlomo-Rikala, Peter Reichardt, Mikael Eriksson, Kirsten Sundby Hall, Eva Wardelmann, Aki Vehtari, Heikki Joensuu, Harri Sihto
BACKGROUND: The SLUG transcription factor has been linked with the KIT signalling pathway that is important for gastrointestinal stromal tumour (GIST) tumourigenesis. Its clinical significance in GIST is unknown. METHODS: Influence of SLUG expression on cell proliferation and viability were investigated in GIST48 and GIST882 cell lines. The association between tumour SLUG expression in immunohistochemistry and recurrence-free survival (RFS) was studied in two clinical GIST series, one with 187 patients treated with surgery alone, and another one with 313 patients treated with surgery and adjuvant imatinib...
April 25, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28253424/botulinum-toxin-for-the-treatment-of-strabismus
#20
REVIEW
Fiona J Rowe, Carmel P Noonan
BACKGROUND: The use of botulinum toxin as an investigative and treatment modality for strabismus is well reported in the medical literature. However, it is unclear how effective it is in comparison to other treatment options for strabismus. OBJECTIVES: The primary objective was to examine the efficacy of botulinum toxin therapy in the treatment of strabismus compared with alternative conservative or surgical treatment options. This review sought to ascertain those types of strabismus that particularly benefit from the use of botulinum toxin as a treatment option (such as small angle strabismus or strabismus with binocular potential, i...
March 2, 2017: Cochrane Database of Systematic Reviews
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