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https://www.readbyqxmd.com/read/28227990/using-computational-phantoms-to-improve-delivery-of-tumor-treating-fields-ttfields-to-patients
#1
Ze'ev Bomzon, Hadas Sara Hershkovich, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Anders R Korshoej, Uri Weinberg, Cornelia Wenger, Pedro Miranda, Yoram Wasserman, Eilon D Kirson, Yoram, Ze'ev Bomzon, Hadas Sara Hershkovich, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Anders R Korshoej, Uri Weinberg, Cornelia Wenger, Pedro Miranda, Yoram Wasserman, Eilon D Kirson, Yoram, Uri Weinberg, Cornelia Wenger, Noa Urman, Hadas Sara Hershkovich, Yoram Wasserman, Anders R Korshoej, Eilon D Kirson, Dario Garcia-Carracedo, Pedro Miranda, Aafia Chaudhry, Zeev Bomzon, Yoram
This paper reviews the state-of-the-art in simulation-based studies of Tumor Treating Fields (TTFields) and highlights major aspects of TTFields in which simulation-based studies could affect clinical outcomes. A major challenge is how to simulate multiple scenarios rapidly for TTFields delivery. Overcoming this challenge will enable a better understanding of how TTFields distribution is correlated with disease progression, leading to better transducer array designs and field optimization procedures, ultimately improving patient outcomes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226993/first-steps-to-creating-a-platform-for-high-throughput-simulation-of-ttfields
#2
Hadas Sara Hershkovich, Zeev Bomzon, Cornelia Wenger, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Eilon D Kirson, Uri Weinberg, Yoram Wassermann, Yoram Palti, Hadas Sara Hershkovich, Zeev Bomzon, Cornelia Wenger, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Eilon D Kirson, Uri Weinberg, Yoram Wassermann, Yoram Palti, Yoram Wassermann, Cornelia Wenger, Uri Weinberg, Hadas Sara Hershkovich, Zeev Bomzon, Eilon D Kirson, Dario Garcia-Carracedo, Yoram Palti, Noa Urman, Aafia Chaudhry
Tumor Treating Fields (TTFields) are low intensity alternating electric fields in the 100-500 KHz frequency range that are known to have an anti-mitotic effect on cancerous cells. In the USA, TTFields are approved by the Food and Drug Administration (FDA) for the treatment of glioblastoma (GBM) in both the newly diagnosed and recurrent settings. Optimizing treatment with TTFields requires a deep understanding of how TTFields distribute within the brain. To address this issue, simulations using realistic head models have been performed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28222617/presynaptic-calmodulin-targets-lessons-from-structural-proteomics
#3
Noa Lipstein, Melanie Göth, Christine Piotrowski, Kevin Pagel, Andrea Sinz, Olaf Jahn
Calmodulin (CaM) is a highly conserved Ca(2+)-binding protein that is exceptionally abundant in the brain. In the presynaptic compartment of neurons, CaM transduces changes in Ca(2+) concentration into the regulation of synaptic transmission dynamics. Areas covered: We review selected literature including published CaM interactor screens and outline established and candidate presynaptic CaM targets. We present a workflow of biochemical and structural proteomic methods that were used to identify and characterize the interactions between CaM and Munc13 proteins...
March 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28221831/behavioral-hypervolumes-of-predator-groups-and-predator-predator-interactions-shape-prey-survival-rates-and-selection-on-prey-behavior
#4
Jonathan N Pruitt, Kimberly A Howell, Shaniqua J Gladney, Yusan Yang, James L L Lichtenstein, Michelle Elise Spicer, Sebastian A Echeverri, Noa Pinter-Wollman
Predator-prey interactions often vary on the basis of the traits of the individual predators and prey involved. Here we examine whether the multidimensional behavioral diversity of predator groups shapes prey mortality rates and selection on prey behavior. We ran individual sea stars (Pisaster ochraceus) through three behavioral assays to characterize individuals' behavioral phenotype along three axes. We then created groups that varied in the volume of behavioral space that they occupied. We further manipulated the ability of predators to interact with one another physically via the addition of barriers...
March 2017: American Naturalist
https://www.readbyqxmd.com/read/28217657/patient-compliance-with-new-oral-anticoagulants-after-major-orthopaedic-surgery-rivaroxaban-and-dabigatran-compared-with-subcutaneous-injection-of-fondaparinux
#5
Paolo DI Benedetto, Luigi Vetrugno, Dania DE Franceschi, Renato Gisonni, Araldo Causero, Giorgio Della Rocca
PURPOSE: the main purpose of our study was to compare patient compliance with the orally administered new oral anticoagulants (NOCs) dabigatran and rivaroxaban compared with subcutaneously injected fondaparinux after major orthopaedic surgery, and to assess patient preference for the oral vs subcutaneous administration route. METHODS: prophylactic antithrombotic drug therapy with dabigatran (group D; GD, n=32 patients), rivaroxaban (group R; GR, n=38 patients) or fondaparinux (group F; GF, n=30 patients), to prevent deep vein thrombosis, was started immediately after surgery in 100 patients submitted to total hip arthroplasty...
October 2016: Joints
https://www.readbyqxmd.com/read/28216082/semi-automated-program-for-analysis-of-local-ca-2-spark-release-with-application-for-classification-of-heart-cell-type
#6
REVIEW
Moran Davoodi, Sofia Segal, Noa Kirschner Peretz, David Kamoun, Yael Yaniv
Local Ca(2+) spark releases are essential to the Ca(2+) cycling process. Thus, they play an important role in ventricular and atrial cell contraction, as well as in sinoatrial cell automaticity. Characterizing their properties in healthy cells from different regions in the heart can reveal the basic biophysical differences among these regions. We designed a semi-automatic Matlab Graphical User Interface (called Sparkalyzer) to characterize parameters of Ca(2+) spark release from any major cardiac tissue, as recorded in line-scan mode with a confocal laser-scanning microscope...
February 9, 2017: Cell Calcium
https://www.readbyqxmd.com/read/28210620/association-of-ptpn22-haplotypes-1123g-c-1858c-t-with-rheumatoid-arthritis-in-western-mexican-population
#7
Yeniley Ruiz-Noa, Jorge Ramón Padilla-Gutiérrez, Jorge Hernández-Bello, Claudia Azucena Palafox-Sánchez, Yeminia Valle, Edith Oregón-Romero, Ana Laura Pereira-Suárez, Ana Guilaisne Bernard-Medina, José Francisco Muñoz-Valle
Rheumatoid arthritis (RA) is an autoimmune disease characterized by the presence of antibodies against cyclic citrullinated peptide (anti-CCP), a consequence of the breakdown of immune tolerance. The lymphoid tyrosine phosphatase (Lyp) protein has significant effects on maintenance of peripheral immune tolerance. Two polymorphic variants (-1123G>C and +1858C>T) at PTPN22 gene that encodes this protein have been associated with autoimmune disorders and found in strong linkage disequilibrium in Caucasian population...
2017: International Journal of Genomics
https://www.readbyqxmd.com/read/28210451/dental-management-of-patients-taking-novel-oral-anticoagulants-noas-dabigatran
#8
REVIEW
Adrian Curto, Alberto Albaladejo, Alfonso Alvarado
BACKGROUND: A new group of oral anticoagulants (dabigatran, rivaroxaban, apixaban and edoxaban) with clear advantages over classic dicoumarin oral anticoagulants (warfarin and acenocoumarol) has been developed in recent years. Patients being treated with oral anticoagulants are at higher risk for bleeding when undergoing dental treatments. MATERIAL AND METHODS: A literature search was conducted through April 2016 for publications in the ISI Web of Knowledge, PubMed and Cochrane Library using the keywords "dabigatran", "rivaroxaban", "apixaban", "edoxaban", "new oral anticoagulants", "novel oral anticoagulants", "bleeding" and "dental treatment"...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209780/microtubule-associated-protein-4-map4-controls-nanovesicle-dynamics-and-t-cell-activation
#9
Eugenio Bustos-Morán, Noelia Blas-Rus, Noa Martin-Cófreces, Francisco Sánchez-Madrid
The Immune Synapse (IS) is a specialized structure formed at the contact area between T lymphocytes and antigen-presenting cells (APC), essential for the adaptive immune response. Proper T cell activation requires its polarization towards the APC, which is highly dependent on the tubulin cytoskeleton. Microtubule associated protein-4 (MAP4) is a microtubule (MT)-stabilizing protein that controls MTs in physiological processes such as cell division, migration, vesicular transport or primary cilia formation. In this study, we have assessed the role of MAP4 in T cell activation...
February 16, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28204967/advantageous-solubility-permeability-interplay-when-using-amorphous-solid-dispersion-asd-formulation-for-the-bcs-class-iv-p-gp-substrate-rifaximin-simultaneous-increase-of-both-the-solubility-and-the-permeability
#10
Avital Beig, Noa Fine-Shamir, David Lindley, Jonathan M Miller, Arik Dahan
Rifaximin is a BCS class IV (low-solubility, low-permeability) drug and also a P-gp substrate. The aims of this work were to assess the efficiency of different rifaximin amorphous solid dispersion (ASDs) formulations in achieving and maintaining supersaturation and to investigate the consequent solubility-permeability interplay. Spray-dried rifaximin ASDs were prepared with different hydrophilic polymers and their ability to achieve and maintain supersaturation was assessed. Then, rifaximin's apparent intestinal permeability was investigated as a function of increasing supersaturation both in vitro using the parallel artificial membrane permeability assay (PAMPA) and in vivo using the single-pass rat intestinal perfusion (SPIP) model...
February 15, 2017: AAPS Journal
https://www.readbyqxmd.com/read/28202133/toddlers-later-diagnosed-with-autism-exhibit-multiple-structural-abnormalities-in-temporal-corpus-callosum-fibers
#11
Noa Fingher, Ilan Dinstein, Michal Ben-Shachar, Shlomi Haar, Anders M Dale, Lisa Eyler, Karen Pierce, Eric Courchesne
Interhemispheric functional connectivity abnormalities are often reported in autism and it is thus not surprising that structural defects of the corpus callosum (CC) are consistently found using both traditional MRI and DTI techniques. Past DTI studies however, have subdivided the CC into 2 or 3 segments without regard for where fibers may project to within the cortex, thus placing limitations on our ability to understand the nature, timing and neurobehavioral impact of early CC abnormalities in autism. Leveraging a unique cohort of 97 toddlers (68 autism; 29 typical) we utilized a novel technique that identified seven CC tracts according to their cortical projections...
January 23, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28198147/intrahepatic-fat-abdominal-adipose-tissues-and-metabolic-state-magnetic-resonance-imaging-study
#12
Anat Yaskolka Meir, Lilac Tene, Noa Cohen, Ilan Shelef, Dan Schwarzfuchs, Yftach Gepner, Hila Zelicha, Michal Rein, Nitzan Bril, Dana Serfaty, Shira Kenigsbuch, Yoash Chassidim, Benjamin Sarusy, Dror Dicker, Joachim Thiery, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Meir J Stampfer, Assaf Rudich, Iris Shai
BACKGROUND: Intrahepatic-fat (IHF) is best known to associate with waist circumference (WC) and visceral-adipose-tissue (VAT), but its relation to abdominal subcutaneous-adipose tissue (SAT) is controversial. While IHF > 5% dichotomously defines fatty liver, %IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate %IHF association with abdominal fat sub-depots, pancreatic and renal-sinus fats. METHODS: We evaluated %IHF, abdominal fat sub-depots, %pancreatic and renal-sinus fats, among individuals with moderate abdominal obesity, using 3-T magnetic resonance imaging (MRI)...
February 14, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28192369/synaptic-unc13a-protein-variant-causes-increased-neurotransmission-and-dyskinetic-movement-disorder
#13
Noa Lipstein, Nanda M Verhoeven-Duif, Francesco E Michelassi, Nathaniel Calloway, Peter M van Hasselt, Katarzyna Pienkowska, Gijs van Haaften, Mieke M van Haelst, Ron van Empelen, Inge Cuppen, Heleen C van Teeseling, Annemieke M V Evelein, Jacob A Vorstman, Sven Thoms, Olaf Jahn, Karen J Duran, Glen R Monroe, Timothy A Ryan, Holger Taschenberger, Jeremy S Dittman, Jeong-Seop Rhee, Gepke Visser, Judith J Jans, Nils Brose
Munc13 proteins are essential regulators of neurotransmitter release at nerve cell synapses. They mediate the priming step that renders synaptic vesicles fusion-competent, and their genetic elimination causes a complete block of synaptic transmission. Here we have described a patient displaying a disorder characterized by a dyskinetic movement disorder, developmental delay, and autism. Using whole-exome sequencing, we have shown that this condition is associated with a rare, de novo Pro814Leu variant in the major human Munc13 paralog UNC13A (also known as Munc13-1)...
February 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28187504/extreme-spermatogenesis-failure-andrological-phenotype-and-intracytoplasmic-sperm-injection-outcomes
#14
P Plouvier, A-L Barbotin, F Boitrelle, D Dewailly, V Mitchell, J-M Rigot, V Lefebvre-Khalil, G Robin
Patients with very low sperm count through direct sperm examination can exhibit extreme oligozoospermia or cryptozoospermia (after centrifugation). The management of these patients is a real challenge for both clinicians and biologists. In this retrospective and comparative cohort study, we compared the andrological phenotype of patients with extreme alterations of spermatogenesis and assessed whether the origin of spermatozoa (testicular or ejaculate) had any influence on intracytoplasmic sperm injection (ICSI) outcomes...
February 10, 2017: Andrology
https://www.readbyqxmd.com/read/28181510/strong-coupling-and-high-contrast-all-optical-modulation-in-atomic-cladding-waveguides
#15
Liron Stern, Boris Desiatov, Noa Mazurski, Uriel Levy
In recent years, there has been marked increase in research aimed to introduce alkali vapours into guided-wave configurations. Owing to the significant reduction in device dimensions, the increase in density of states, the interaction with surfaces and primarily the high intensities carried along the structure, a plethora of light-vapour interactions can be studied. Moreover, such platform may exhibit new functionalities such as low-power nonlinear light-matter interactions. One immense challenge is to study the effects of quantum coherence and shifts in nanoscale waveguides, characterized by ultra-small mode areas and fast dynamics...
February 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28176183/improving-the-visual-field-in-coronary-artery-by-with-non-obstructive-angioscopy-dual-infusion-method
#16
Sei Komatsu, Tomoki Ohara, Satoru Takahashi, Mitsuhiko Takewa, Chikao Yutani, Kazuhisa Kodama
Non-obstructive angioscopy (NOA) is used to visualize the surface of the coronary artery, and a clear visual field is obtained by injecting transparent fluid into the gap between the probing catheter and the fiber. This study examines visual field expansion by a dual infusion method, which involves an infusion from the probing and guiding catheters, and the relationships between visual grade and vessel characteristics. Thirty-two patients and thirty patients performed coronary plaque analysis with NOA using the conventional method and the novel dual infusion method, respectively...
February 7, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28162982/revival-of-old-antibiotics-needs-the-state-of-evidence-and-expectations
#17
Hiba Zayyad, Noa Eliakim-Raz, Leonard Leibovici, Mical Paul
The gap between the emergence of antibiotic resistance and new antibiotic development has drawn attention to old antibiotics whose spectrum of coverage frequently comprises highly resistant bacteria. However, these antibiotics have frequently not undergone the structured process of antibiotic development of modern antibiotics, from pharmacokinetic/pharmacodynamic (PK/PD) studies establishing safe and effective dosing, establishment of susceptibility breakpoints, to clinical trials establishing clinical safety and effectiveness...
February 2, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28157111/waist-up-protection-for-blind-individuals-using-the-eyecane-as-a-primary-and-secondary-mobility-aid
#18
Galit Buchs, Noa Simon, Shachar Maidenbaum, Amir Amedi
BACKGROUND: One of the most stirring statistics in relation to the mobility of blind individuals is the high rate of upper body injuries, even when using the white-cane. OBJECTIVE: We here addressed a rehabilitation- oriented challenge of providing a reliable tool for blind people to avoid waist-up obstacles, namely one of the impediments to their successful mobility using currently available methods (e.g., white-cane). METHODS: We used the EyeCane, a device we developed which translates distances from several angles to haptic and auditory cues in an intuitive and unobtrusive manner, serving both as a primary and secondary mobility aid...
February 2, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28145283/accurate-description-of-the-electronic-structure-of-organic-semiconductors-by-gw-methods
#19
Noa Marom
Electronic properties associated with charged excitations, such as the ionization potential (IP), the electron affinity (EA), and the energy level alignment at interfaces, are critical parameters for the performance of organic electronic devices. To computationally design organic semiconductors and functional interfaces with tailored properties for target applications it is necessary to accurately predict these properties from first principles. Many-body perturbation theory is often used for this purpose within the GW approximation, where G is the one particle Green's function and W is the dynamically screened Coulomb interaction...
March 15, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28142364/increasing-recreational-physical-activity-in-patients-with-chronic-low-back-pain-a-pragmatic-controlled-clinical-trial
#20
Noa Ben-Ami, Gabriel Chodick, Yigal Mirovsky, Tamar Pincus, Yair Shapiro
Study Design Prospective, pragmatic, nonrandomized controlled clinical trial. Background Clinical guidelines recommend physical activity for the treatment of chronic low back pain. But engaging patients in physical activity has proven difficult. Known obstacles to physical activity include low self-efficacy and fear avoidance. Objectives This study tested the effectiveness of an enhanced transtheoretical model intervention (ETMI) aimed at increasing recreational physical activity in patients with chronic low back pain, in comparison to usual physical therapy...
February 2017: Journal of Orthopaedic and Sports Physical Therapy
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