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https://www.readbyqxmd.com/read/28518093/determining-the-optimal-inhibitory-frequency-for-cancerous-cells-using-tumor-treating-fields-ttfields
#1
Yaara Porat, Moshe Giladi, Rosa S Schneiderman, Roni Blat, Anna Shteingauz, Einav Zeevi, Mijal Munster, Tali Voloshin, Noa Kaynan, Orna Tal, Eilon D Kirson, Uri Weinberg, Yoram Palti
Tumor Treating Fields (TTFields) are an effective treatment modality delivered via the continuous, noninvasive application of low-intensity (1-3 V/cm), alternating electric fields in the frequency range of several hundred kHz. The study of TTFields in tissue culture is carried out using the TTFields in vitro application system, which allows for the application of electric fields of varying frequencies and intensities to ceramic Petri dishes with a high dielectric constant (Ɛ > 5,000). Cancerous cell lines plated on coverslips at the bottom of the ceramic Petri dishes are subjected to TTFields delivered in two orthogonal directions at various frequencies to facilitate treatment outcome tests, such as cell counts and clonogenic assays...
May 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28510730/trimethoprim-sulfamethoxazole-versus-vancomycin-in-the-treatment-of-healthcare-ventilator-associated-mrsa-pneumonia-a-case-control-study
#2
Noa Eliakim-Raz, Moran Hellerman, Dafna Yahav, Jonathan Cohen, Ili Margalit, Sharon Fisher, Oren Zusman, Hila Shaked, Jihad Bishara
No abstract text is available yet for this article.
May 16, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28505795/parallelization-of-microfluidic-flow-focusing-devices
#3
Esther Amstad, Xiaoming Chen, Max Eggersdorfer, Noa Cohen, Thomas E Kodger, Carolyn L Ren, David A Weitz
Microfluidic flow-focusing devices offer excellent control over fluid flow, enabling formation of drops with a narrow size distribution. However, the throughput of microfluidic flow-focusing devices is limited and scale-up through operation of multiple drop makers in parallel often compromises the robustness of their operation. We demonstrate that parallelization is facilitated if the outer phase is injected from the direction opposite to that of the inner phase, because the fluid injection flow rate, where the drop formation transitions from the squeezing into the dripping regime, is shifted towards higher values...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28505451/toward-successful-cyclodextrin-based-solubility-enabling-formulations-for-oral-delivery-of-lipophilic-drugs-solubility-permeability-tradeoff-biorelevant-dissolution-and-the-unstirred-water-layer
#4
Noa Fine-Shamir, Avital Beig, Moran Zur, David Lindley, Jon Miller, Arik Dahan
The purpose of this work was to investigate key factors dictating the success/failure of cyclodextrin-based solubility-enabling formulations for oral delivery of low-solubility drugs. We have studied the solubility, the permeability, and the solubility-permeability interplay, of the highly lipophilic drug danazol, formulated with different levels (8.5, 10, 20 and 30%) of the commonly used hydroxypropyl-β-cyclodextrin (HPβCD), accounting for the biorelevant solubilization of the drug along the gastrointestinal tract (GIT), the unstirred water layer (UWL) adjacent to the GI membrane, and the overall absorption...
May 15, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28501438/investigating-drug-absorption-from-the-colon-single-pass-vs-doluisio-approaches-to-in-situ-rat-large-intestinal-perfusion
#5
Isabel Lozoya-Agullo, Moran Zur, Noa Fine-Shamir, Milica Markovic, Yael Cohen, Daniel Porat, Isabel González-Álvarez, Marta González-Álvarez, Matilde Merino-Sanjuán, Marival Bermejo, Arik Dahan
Traditionally, the colon is considered a secondary intestinal segment in the drug absorption process. However, in many cases the role of colonic drug permeability cannot be overlooked. The purpose of this research was to compare colon permeability data obtained using two different rat perfusion methods the single-pass intestinal perfusion (SPIP) approach and the closed-loop (Doluisio) perfusion model. A list of 14 structurally diverse model drugs was constructed, and their rat colon permeability was studied using the two methods The two sets of results were compared to each other, and were evaluated vs...
May 10, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28501343/changes-of-renal-sinus-fat-and-renal-parenchymal-fat-during-an-18-month-randomized-weight-loss-trial
#6
Hila Zelicha, Dan Schwarzfuchs, Ilan Shelef, Yftach Gepner, Gal Tsaban, Lilac Tene, Anat Yaskolka Meir, Avital Bilitzky, Oded Komy, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Yoash Chassidim, Benjamin Sarusi, Joachim Thiery, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Yosef S Haviv, Meir J Stampfer, Assaf Rudich, Iris Shai
BACKGROUND & AIMS: Data regarding the role of kidney adiposity, its clinical implications, and its dynamics during weight-loss are sparse. We investigated the effect of long-term weight-loss induced intervention diets on dynamics of renal-sinus-fat, an ectopic fat depot, and %renal-parenchymal-fat, lipid accumulation within the renal parenchyma. METHODS: We randomized 278 participants with abdominal obesity/dyslipidemia to low-fat or Mediterranean/low-carbohydrate diets, with or without exercise...
May 2, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28495454/intratesticular-and-incisional-line-infiltration-with-ropivacaine-for-castration-in-medetomidine-butorphanol-midazolam-sedated-dogs
#7
Yishai Kushnir, Noa Toledano, Liat Cohen, Tali Bdolah-Abram, Yael Shilo-Benjamini
OBJECTIVE: To evaluate whether intratesticular and incisional ropivacaine infiltration produces sufficient intra- and postoperative analgesia for castrating dogs under sedation. STUDY DESIGN: Randomized, blinded, controlled clinical study. ANIMALS: Twenty-three healthy dogs weighing 5.8-35.6 kg admitted for castration. METHODS: Dogs were sedated with medetomidine (0.01 mg kg(-1)), butorphanol (0.2 mg kg(-1)) and midazolam (0...
January 11, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/28485304/synthesis-of-polymer-bead-nano-necklaces-on-aligned-carbon-nanotube-scaffolds
#8
Noa Lachman, Itai Y Stein, Asli Ugur, Dale Lidston, Karen Gleason, Brian Wardle
Here, we report the fabrication of aligned carbon nanotube (A-CNT)/conducting polymer (CP) heterostructures with both uniform conformal and periodic beaded polymer morphologies <i>via</i> oxidative chemical vapor deposition of poly(ethylenedioxythiophene). Periodic beaded CP morphologies are realized utilizing the Plateau-Rayleigh instability to transform the original uniform conformal film, yielding a beaded CP morphology with a > 50% enhancement in specific surface area. Modeling indicates that this specific surface area increase originates from the internal volume of the A-CNTs becoming available for adsorption, and that these internal A-CNT surfaces, if they could be made accessible to electrolyte ions, could lead to > 30% enhancement of specific gravimetric and volumetric capacitances of current state-of-the-art A-CNT/CP heterostructures...
May 9, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28481808/intraluminal-uterine-hypodensity-in-ct-scans-of-postmenopausal-women-recommendations-for-interpretation
#9
Michal Marianne Amitai, Mohamad Yassin, Nayrouz Kanana, Sara Apter, Noa Rozendorn, Eli Konen, Eyal Klang
OBJECTIVE: This study aims to investigate the association between intraluminal uterine hypodensity and uterine malignancy and establish thresholds that would minimize routine gynecological evaluation. METHODS: Two groups were recruited retrospectively: cancer group, which comprised 32 sequential endometrial cancer patients, and postmenopausal group, which comprised 63 women, with no known gynecologic malignancy.Two radiologists independently measured hypodensity, transversely in the axial plane and anterioposteriorly in the sagittal plane...
May 6, 2017: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/28476589/in-vivo-stimulus-presentation-to-the-mouse-vomeronasal-system-surgery-experiment-setup-and-software
#10
Michal Yoles-Frenkel, Oksana Cohen, Rohini Bansal, Noa Horesh, Yoram Ben-Shaul
BACKGROUND: Achieving controlled stimulus delivery is a major challenge in the physiological analysis of the vomeronasal system (VNS). NEW METHOD: We provide a comprehensive description of a setup allowing controlled stimulus delivery into the vomeronasal organ (VNO) of anesthetized mice. VNO suction is achieved via electrical stimulation of the sympathetic nerve trunk (SNT) using cuff electrodes, followed by flushing of the nasal cavity. Successful application of this methodology depends on several aspects including the surgical preparation, fabrication of cuff electrodes, experimental setup modifications, and the stimulus delivery and flushing...
May 3, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28471564/integration-of-ct-based-measurements-into-surveillance-pet-ct-in-patients-with-diffuse-large-b-cell-lymphoma
#11
Noa Lavi, Gali Shapira, Ariel Zilberlicht, Noam Benyamini, Dan Farbstein, Eldad J Dann, Rachel Bar-Shalom, Irit Avivi
BACKGROUND: Despite the lack of clinical studies supporting the use of routine surveillance FDG-positron emission tomography (PET) in patients with diffuse large B cell lymphoma (DLBCL) who achieved remission, many centers still use this strategy, especially in high risk patients. Surveillance FDG-PET computed tomography (CT) is associated with a high false positive (FP) rate in DLBCL patients. OBJECTIVES: To investigate whether use of specific CT measurements could improve the positive predictive value (PPV) of surveillance FDG-PET/CT...
July 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28470504/the-effect-of-food-deprivation-on-human-resolving-power
#12
Noa Zitron-Emanuel, Tzvi Ganel
The feeling of hunger is an inseparable part of people's daily lives. It has been established that hunger, caused by food deprivation, influences people's physiological and emotional state and their everyday behavior. Yet, it remains unclear whether and in which manner food deprivation affects the way people perceive their environment. In two experiments, we examined the effects of food deprivation on the perceptual resolution of food portion size. We calculated Just Noticeable Differences (JNDs) to measure sensitivity to detect the smallest difference between two stimuli of different sizes...
May 3, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28466614/do-you-see-it-my-way-the-clinical-evaluation-of-adhd-by-the-different-pediatric-subspecialties
#13
Yael Leitner, Alexis Mitelpunkt, Idit Posner, Noa Vardi
BACKGROUND: Six medical disciplines are responsible for assessment, diagnosis and treatment of people with attention deficiency hyperactivity disorder (ADHD) in Israel: family doctors, pediatricians, adult and child neurologists, adult and child psychiatrists. OBJECTIVES: To investigate differences in ADHD diagnostic practices between three different pediatric subspecialties in the clinical setting in order to establish a common ground for a future unified approach...
November 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28464381/socioeconomic-status-and-hippocampal-volume-in-children-and-young-adults
#14
Qijing Yu, Ana M Daugherty, Dana M Anderson, Mayu Nishimura, David Brush, Amanda Hardwick, William Lacey, Sarah Raz, Noa Ofen
An individual's socioeconomic status (SES) is often viewed as a proxy for a host of environmental influences. SES disparities have been linked to variance in brain structures particularly the hippocampus, a neural substrate of learning and memory. However, it is unclear whether the association between SES and hippocampal volume is similar in children and adults. We investigated the relationship between hippocampal volume and SES in a group of children (n = 31, age 8-12 years) and a group of young adults (n = 32, age 18-25 years)...
May 2, 2017: Developmental Science
https://www.readbyqxmd.com/read/28457282/outcomes-after-implantable-collamer-lens-surgery-in-a-canadian-cohort
#15
Aaron T Chan, Noa A Zauberman, Clara C Chan, David S Rootman
OBJECTIVE: To describe refractive outcomes and complications after implantable collamer lens (ICL) implantation. DESIGN: Retrospective, interventional case series. METHODS: A database search of ICL surgeries over a 5-year period (2009-2013) was conducted, and 83 eyes of 44 patients were included. The Visian ICL (STAAR Surgical, Monrovia, Calif.) was used in all eyes. The primary outcome measure was postoperative uncorrected distance acuity (UCDA)...
April 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28457154/improving-mental-health-four-secrets-in-plain-sightby-lloyd-i-sederer-m-d-washington-d-c-american-psychiatric-association-publishing-2017-129-pp-29-00-hardcover
#16
https://www.readbyqxmd.com/read/28457080/the-ongoing-debate-regarding-long-term-safety-of-silicone-breast-augmentation-rages
#17
EDITORIAL
Yair Levy, Noa Ruhrman-Shahar
No abstract text is available yet for this article.
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28457073/association-between-enlarged-axillary-lymph-nodes-and-silicone-breast-implant-ruptures-seen-on-magnetic-resonance-imaging
#18
Eyal Klang, Michal M Amitai, Stephen Raskin, Noa Rozendorn, Nicholas Keddel, Jana Pickovsky, Miri Sklair-Levy
BACKGROUND: Silicone breast augmentation is a common cosmetic surgery. Previous case reports demonstrated lymphadenopathy in the presence of implant ruptures. OBJECTIVES: To investigate the association between enlarged axillary lymph nodes and silicone implant ruptures as seen on breast magnetic resonance imaging (MRI). METHODS: Two groups were derived retrospectively from breast MRI reports in our institution for the period December 2011-May 2014...
December 2016: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/28456595/cftr-gene-mutations-and-polymorphism-are-associated-with-non-obstructive-azoospermia-from-case-control-study
#19
Lingying Jiang, Jiamin Jin, Shasha Wang, Fuxing Zhang, Yongdong Dai, Libing Shi, Songying Zhang
A variety of experimental studies have yielded evidence that the cystic fibrosis transmembrane conductance regulator (CFTR) protein participates in the process of spermatogenesis. However, the association between CFTR gene and non-obstructive azoospermia (NOA) disease remained to be a question. First, we reviewed available data from the PubMed and Embase databases before May 2016 to find the most common mutations of CFTR gene in NOA patients. Second, an original case-control study was conducted on NOA patients (n=100) and a control group consisting of fertile males (n=100), selected from August 2015 to March 2017, to detect CFTR gene mutations and polymorphism...
April 26, 2017: Gene
https://www.readbyqxmd.com/read/28451795/distribution-of-osteoarthritis-in-a-norwegian-population-based-cohort-associations-to-risk-factor-profiles-and-health-related-quality-of-life
#20
Guro Økelsrud Lombnæs, Karin Magnusson, Nina Østerås, Lars Nordsletten, May Arna Risberg, Kåre Birger Hagen
The objective of the study was to examine the hand-, knee- and hip osteoarthritis (OA) distribution, risk factor profiles and health-related quality of life (HRQoL) in a population-based OA cohort. Persons with self-reported OA responded to questionnaires and attended a clinical examination (N = 606). We analyzed cross-sectional associations to risk factor profiles and HRQoL dimensions (Short Form 36) in four mutually exclusive groups based on fulfillment of The American College of Rheumatology criteria: no OA (NOA), monoarticular upper extremity (hand) OA (MOAupper-ex...
April 27, 2017: Rheumatology International
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