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https://www.readbyqxmd.com/read/27921326/correlation-of-genetic-results-with-testicular-histology-hormones-and-sperm-retrieval-in-nonobstructive-azoospermia-patients-with-testis-biopsy
#1
W Liu, X Gao, G Ma, L Yan, T Chen, T Li, R-M Yu, J-L Ma
To investigate the frequency and types of genetic results in different testicular histology of patients with nonobstructive azoospermia (NOA), and correlated with hormones and sperm retrieval (SR), a retrospective study was conducted in 286 Chinese NOA patients who underwent testis biopsy and 100 age-matched fertile men as the control group. Chromosome karyotype analyses were performed by the peripheral blood chromosome G-band detection method. Screening of Y chromosome microdeletions of azoospermia factor (AZF) region was performed by polymerase chain reaction (PCR) amplification of 11 sequence-tagged sites (STS)...
December 6, 2016: Andrologia
https://www.readbyqxmd.com/read/27919068/capturing-pairwise-and-multi-way-chromosomal-conformations-using-chromosomal-walks
#2
Pedro Olivares-Chauvet, Zohar Mukamel, Aviezer Lifshitz, Omer Schwartzman, Noa Oded Elkayam, Yaniv Lubling, Gintaras Deikus, Robert P Sebra, Amos Tanay
Chromosomes are folded into highly compacted structures to accommodate physical constraints within nuclei and to regulate access to genomic information. Recently, global mapping of pairwise contacts showed that loops anchoring topological domains (TADs) are highly conserved between cell types and species. Whether pairwise loops synergize to form higher-order structures is still unclear. Here we develop a conformation capture assay to study higher-order organization using chromosomal walks (C-walks) that link multiple genomic loci together into proximity chains in human and mouse cells...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27914477/in-vitro-rescue-of-genital-strains-of-chlamydia-trachomatis-from-interferon-%C3%AE-and-tryptophan-depletion-with-indole-positive-but-not-indole-negative-prevotella-spp
#3
Noa Ziklo, Wilhelmina M Huston, Kuong Taing, Mohammad Katouli, Peter Timms
BACKGROUND: The natural course of sexually transmitted infections caused by Chlamydia trachomatis varies between individuals. In addition to parasite and host effects, the vaginal microbiota might play a key role in the outcome of C. trachomatis infections. Interferon-gamma (IFN-γ), known for its anti-chlamydial properties, activates the expression of indoleamine 2,3-dioxygenase (IDO1) in epithelial cells, an enzyme that catabolizes the amino acid L- tryptophan into N-formylkynurenine, depleting the host cell's pool of tryptophan...
December 3, 2016: BMC Microbiology
https://www.readbyqxmd.com/read/27911014/the-effectiveness-of-an-outdoor-adventure-programme-for-young-children-with-autism-spectrum-disorder-a-controlled-study
#4
Ditza A Zachor, Shira Vardi, Shani Baron-Eitan, Inbal Brodai-Meir, Noa Ginossar, Esther Ben-Itzchak
AIM: Outdoor adventure programmes aim to improve interpersonal relationships using adventurous activities. The current study examined the effectiveness of an outdoor adventure programme in children with autism spectrum disorders (ASD). METHOD: The study included 51 participants (40 males, 11 females; age 3y 4mo-7y 4mo) enrolled in ASD special education kindergartens. Only the intervention group (n=30) participated in the outdoor adventure programme for 13 weeks, completing challenging physical activities that required cooperation and communication with peers and instructors...
December 2, 2016: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/27910998/aurora-a-shines-on-t-cell-activation-through-the-regulation-of-lck
#5
Noelia Blas-Rus, Eugenio Bustos-Morán, Noa B Martín-Cófreces, Francisco Sánchez-Madrid
Different protein kinases control signaling emanating from the T cell receptor (TCR) during antigen-specific T cell activation. Mitotic kinases, e.g. Aurora-A, have been widely studied in the context of mitosis due to their role during microtubule (MT) nucleation, becoming critical regulators of cell cycle progression. We have recently described a specific role for Aurora-A kinase in antigenic T cell activation. Blockade of Aurora-A in T cells severely disrupts the dynamics of MTs and CD3ζ-bearing signaling vesicles during T cell activation...
December 2, 2016: BioEssays: News and Reviews in Molecular, Cellular and Developmental Biology
https://www.readbyqxmd.com/read/27899610/malacards-an-amalgamated-human-disease-compendium-with-diverse-clinical-and-genetic-annotation-and-structured-search
#6
Noa Rappaport, Michal Twik, Inbar Plaschkes, Ron Nudel, Tsippi Iny Stein, Jacob Levitt, Moran Gershoni, C Paul Morrey, Marilyn Safran, Doron Lancet
The MalaCards human disease database (http://www.malacards.org/) is an integrated compendium of annotated diseases mined from 68 data sources. MalaCards has a web card for each of ∼20 000 disease entries, in six global categories. It portrays a broad array of annotation topics in 15 sections, including Summaries, Symptoms, Anatomical Context, Drugs, Genetic Tests, Variations and Publications. The Aliases and Classifications section reflects an algorithm for disease name integration across often-conflicting sources, providing effective annotation consolidation...
November 28, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27888798/mir-103-inhibits-proliferation-and-sensitizes-hemopoietic-tumor-cells-for-glucocorticoid-induced-apoptosis
#7
Shlomit Kfir-Erenfeld, Noa Haggiag, Moshe Biton, Polina Stepensky, Nathalie Assayag-Asherie, Eitan Yefenof
Glucocorticoid (GC) hormones are an important ingredient of leukemia therapy since they are potent inducers of lymphoid cell apoptosis. However, the development of GC resistance remains an obstacle in GC-based treatment. In the present investigation we found that miR-103 is upregulated in GC-sensitive leukemia cells treated by the hormone. Transfection of GC resistant cells with miR-103 sensitized them to GC induced apoptosis (GCIA), while miR-103 sponging of GC sensitive cells rendered them partially resistant...
November 18, 2016: Oncotarget
https://www.readbyqxmd.com/read/27884040/personality-makes-a-difference-attachment-orientation-moderates-theory-of-planned-behavior-prediction-of-cardiac-medication-adherence
#8
Shira Peleg, Noa Vilchinsky, William A Fisher, Abed Khaskia, Morris Mosseri
OBJECTIVE: To achieve a comprehensive understanding of patients' adherence to medication following acute coronary syndrome (ACS), we assessed the possible moderating role played by attachment orientation on the effects of attitudes, subjective norms and perceived behavioral control (PBC), as derived from the Theory of Planned Behavior (TPB; Ajzen, 1991), on intention and reported adherence. METHOD: A prospective longitudinal design was employed. During hospitalization, ACS male patients (N=106) completed a set of self-report questionnaires including socio-demographic variables, attachment orientation, and measures of TPB constructs...
November 24, 2016: Journal of Personality
https://www.readbyqxmd.com/read/27883042/two-novel-viruses-associated-with-the-apis-mellifera-pathogenic-mite-varroa-destructor
#9
Sofia Levin, Noa Sela, Nor Chejanovsky
Varroa destructor infestation of Apis mellifera colonies carries and/or promotes replication of honey bee viruses like the Deformed wing virus, the Varroa destructor virus-1, the Acute bee paralysis virus, the Israeli acute bee paralysis virus and the Kashmir bee virus that have been well described and characterized; but viruses exclusively associated with Varroa were not found. To look for viruses that may associate with- or infect V. destructor we performed deep sequencing (RNA-seq) of RNA extracted from honey bees and mites in Varroa-infested untreated colonies...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27879202/quantifying-%C3%AE-catenin-subcellular-dynamics-and-cyclin-d1-mrna-transcription-during-wnt-signaling-in-single-living-cells
#10
Pinhas Kafri, Sarah E Hasenson, Itamar Kanter, Jonathan Sheinberger, Noa Kinor, Sharon Yunger, Yaron Shav-Tal
Signal propagation from the cell membrane to a promoter can induce gene expression. To examine signal transmission through sub-cellular compartments and its effect on transcription levels in individual cells within a population, we used the Wnt/β-catenin signaling pathway as a model system. Wnt signaling orchestrates a response through nuclear accumulation of β-catenin in the cell population. However, quantitative live-cell measurements in individual cells showed variability in nuclear β-catenin accumulation, which could occur in two waves, followed by slow clearance...
November 23, 2016: ELife
https://www.readbyqxmd.com/read/27868267/reduced-microrna-188-3p-expression-contributes-to-apoptosis-of-spermatogenic-cells-in-patients-with-azoospermia
#11
Wen-Yan Song, Hui Meng, Xue-Gai Wang, Hai-Xia Jin, Gui-Dong Yao, Sen-Lin Shi, Liang Wu, Xiang-Yang Zhang, Ying-Pu Sun
BACKGROUND AND AIMS: Human mutL homologl (MLH1) works coordinately in sequential steps to initiate repair of DNA mismatches, and aberrant MLH1 expression is related to spermatogenetic malfunction. In the present study, MLH1 expression in patients with azoospermia was investigated, and moderating effects of miR-188-3p on MLH1 expression and spermatogenesis were identified. METHODS: Testicular tissues from 16 patients with obstructive azoospermia (OA) and non-obstructive azoospermia (NOA), and tissues of eight healthy patients were collected...
November 21, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27868151/eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-relapsing-as-bullous-eruption-a-rare-cutaneous-manifestation-with-an-emphasis-on-histopathological-features
#12
Shany Sherman, Noa Gal, Elena Didkovsky, Yair Molad, Lev Pavlovsky, Emmilia Hodak
is missing (Short communication).
November 10, 2016: Acta Dermato-venereologica
https://www.readbyqxmd.com/read/27862600/a-harmonized-segmentation-protocol-for-hippocampal-and-parahippocampal-subregions-why-do-we-need-one-and-what-are-the-key-goals
#13
Laura E M Wisse, Ana M Daugherty, Rosanna K Olsen, David Berron, Valerie A Carr, Craig E L Stark, Robert S C Amaral, Katrin Amunts, Jean C Augustinack, Andrew R Bender, Jeffrey D Bernstein, Marina Boccardi, Martina Bocchetta, Alison Burggren, M Mallar Chakravarty, Marie Chupin, Arne Ekstrom, Robin de Flores, Ricardo Insausti, Prabesh Kanel, Olga Kedo, Kristen M Kennedy, Geoffrey A Kerchner, Karen F LaRocque, Xiuwen Liu, Anne Maass, Nicolai Malykhin, Susanne G Mueller, Noa Ofen, Daniela J Palombo, Mansi B Parekh, John B Pluta, Jens C Pruessner, Naftali Raz, Karen M Rodrigue, Dorothee Schoemaker, Andrea T Shafer, Trevor A Steve, Nanthia Suthana, Lei Wang, Julie L Winterburn, Michael A Yassa, Paul A Yushkevich, Renaud la Joie
The advent of high-resolution magnetic resonance imaging (MRI) has enabled in vivo research in a variety of populations and diseases on the structure and function of hippocampal subfields and subdivisions of the parahippocampal gyrus. Because of the many extant and highly discrepant segmentation protocols, comparing results across studies is difficult. To overcome this barrier, the Hippocampal Subfields Group was formed as an international collaboration with the aim of developing a harmonized protocol for manual segmentation of hippocampal and parahippocampal subregions on high-resolution MRI...
October 24, 2016: Hippocampus
https://www.readbyqxmd.com/read/27859001/a-phase-iib-trial-of-vorinostat-in-combination-with-lenalidomide-and-dexamethasone-in-patients-with-multiple-myeloma-refractory-to-previous-lenalidomide-containing-regimens
#14
Larysa Sanchez, David H Vesole, Joshua R Richter, Noa Biran, Elizabeth Bilotti, Laura McBride, Palka Anand, Kristin Ivanovski, David S Siegel
Clinical trials of vorinostat, a Class I/II histone deacetylase inhibitor, in combination with proteasome inhibitors and immunomodulatory agents have shown activity in relapsed/refractory multiple myeloma. This phase IIb, open-label, single-institution study evaluated the efficacy of vorinostat in combination with lenalidomide and dexamethasone in lenalidomide-refractory patients. Patients were considered lenalidomide-refractory if they had no clinical response (<minimal response) on a previous lenalidomide-containing regimen (lenalidomide non-responsive) or if they had progressive disease on or within 60 days of discontinuing a previous lenalidomide-containing regimen (lenalidomide relapsed/refractory)...
November 18, 2016: British Journal of Haematology
https://www.readbyqxmd.com/read/27856941/the-quest-to-extend-health-services-to-vulnerable-substance-users-in-rio-de-janeiro-brazil-in-the-context-of-an-unfolding-economic-crisis
#15
Noa Krawczyk, Deanna Kerrigan, Francisco Inácio Bastos
Calls to address crack-cocaine use in Brazil among homeless and street-frequenting populations who are in urgent need of health services have questioned the capacity of the Brazilian Unified Health System to attend to the nation's most marginalized citizens. In recent years, Brazil has launched several actions to escalate care for substance users, yet many obstacles hindering accessibility and effectiveness of services remain. Paradoxically, these actions have been implemented in the context of a growing economic crisis, and expanding services for a population of poor and stigmatized substance users while cutting other government programs tends to elicit harsh criticism from citizens...
November 16, 2016: International Journal of Health Services: Planning, Administration, Evaluation
https://www.readbyqxmd.com/read/27854382/the-truffle-study-fetal-monitoring-indications-for-delivery-in-310-iugr-infants-with-2-year-s-outcome-delivered-before-32-weeks-of-gestation
#16
Gerard H A Visser, C M Bilardo, J B Derks, E Ferrazzi, N Fratelli, T Frusca, W Ganzevoort, C Lees, R Napolitano, T Todros, H Wolf, K Hecher, N Marlow, B Arabin, C Brezinka, A Diemert, J J Duvekot, P Martinelli, E Ostermayer, A T Papageorghiou, D Schlembach, Ktm Schneider, B Thilaganathan, A Valcamonico
OBJECTIVE: In the TRUFFLE study on outcome of early fetal growth restriction women were allocated to three timing of delivery plans according to antenatal monitoring strategies based on reduced computerized cardiotocographic heart rate short term variation (c-CTG STV) , early Ductus Venosus (DV p95) or late DV (DV noA) changes. However, many infants were per protocol delivered because of 'safety net' criteria, or for maternal indications, or 'other fetal indications' or after 32 weeks of gestation when the protocol was not applied anymore...
November 11, 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27850789/1152-display-features-that-improve-interpretation-of-critical-care-information-a-systematic-review
#17
Melanie Wright, Rosalie Waller, Paige Nesbitt, Noa Segall, Damian Borbolla, Thomas Reese, Guilherme Del Fiol
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850785/1148-graphical-display-of-patient-information-improves-outcomes-in-critical-care-a-systematic-review
#18
Rosalie Waller, Noa Segall, Damian Borbolla, Paige Nesbitt, Thomas Reese, Guilherme Del Fiol, Melanie Wright
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27846760/outcome-of-breastfed-infants-following-post-partum-methylergonovine-treatment
#19
Oded Gilad, Paul Merlob, Bracha Stahl, Noa Averbuch, Gil Klinger
OBJECTIVE: To evaluate maternal and breastfed infant's outcome following post-partum maternal use of methylergonovine. METHODS: A prospective, controlled observational study design was used. Mothers who contacted Beilinson Teratology Information Service (BELTIS) were followed by phone interview. Data on lactation, neonatal symptoms and outcomes at the age of 1-3 years were obtained. Mothers' breastfeeding while treated with methylergonovine and their infants were compared to a matched control group of breastfeeding mothers using a drug known to be safe during lactation (amoxicillin)...
November 16, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27834706/genome-sequence-of-a-potential-new-benyvirus-isolated-from-mango-rna-seq-data
#20
Noa Sela, Neta Luria, Mor Yaari, Dov Prusky, Aviv Dombrovsky
We report here the sequence of a new benyvirus found through mango cultivar Shelly RNA-seq analysis in Israel. This is the first virus strain reported in mango trees.
November 10, 2016: Genome Announcements
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