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https://www.readbyqxmd.com/read/28719885/racial-and-ethnic-differences-in-opioid-agonist-treatment-for-opioid-use-disorder-in-a-u-s-national-sample
#1
Noa Krawczyk, Kenneth A Feder, Michael I Fingerhood, Brendan Saloner
BACKGROUND: Opioid Agonist Treatment (OAT) is the standard of care for the treatment of opioid use disorders. However, most people in treatment do not receive OAT. This study evaluated whether there are racial and/or ethnic differences in OAT receipt among adults entering specialty treatment for opioid use disorders in publicly-funded treatment programs across the U.S. METHODS: Using data from the national Treatment: Episode Data Base, odds of OAT receipt were compared among black, Hispanic and white clients...
July 11, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28717888/acetabular-labral-reconstruction-using-the-indirect-head-of-the-rectus-femoris-tendon-significantly-improves-patient-reported-outcomes
#2
Eyal Amar, Thomas G Sampson, Zachary T Sharfman, Alyssa Caplan, Noa Rippel, Ran Atzmon, Michael Drexler, Ehud Rath
PURPOSE AND HYPOTHESIS: The aim of this study was to evaluate outcomes after acetabular labral reconstruction using the indirect head of the rectus femoris tendon. The study hypothesis stated that arthroscopic acetabular labral reconstruction may improve patient reported outcomes in patients with labral tears that were not amenable to repair. METHODS: Between 2009 and 2015, the senior author performed 31 acetabular labral reconstructions using the indirect head of the rectus femoris tendon...
July 17, 2017: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/28703337/paternal-age-as-an-independent-factor-does-not-affect-embryo-quality-and-pregnancy-outcomes-of-testicular-sperm-extraction-intracytoplasmic-sperm-injection-in-azoospermia
#3
Y S Park, S H Lee, C K Lim, H W Choi, J H An, C W Park, H S Lee, J S Lee, J T Seo
This study was performed to evaluate the independent influence of paternal age affecting embryo development and pregnancy using testicular sperm extraction (TESE)-intracytoplasmic sperm injection (ICSI) in obstructive azoospermia (OA) and nonobstructive azoospermia (NOA). Paternal patients were divided into the following groups: ≤30 years, 31-35 years, 36-40 years, 41-45 years and ≥46 years. There were no differences in the rates of fertilisation or embryo quality according to paternal and maternal age...
July 13, 2017: Andrologia
https://www.readbyqxmd.com/read/28693243/rt-qpcr-for-phox2b-mrna-is-a-highly-specific-and-sensitive-method-to-assess-neuroblastoma-minimal-residual-disease-in-testicular-tissue
#4
Victoria Grèze, Justyna Kanold, Fanny Chambon, Pascale Halle, Anne-Sophie Gremeau, Nathalie Rives, Nadège Rouel, Bruno Pereira, Andrei Tchirkov, Florence Brugnon
Neuroblastoma (NB) is the most common type of extracranial solid tumor in children with a high prevalence in toddlers. For childhood cancer survivors, preservation of reproductive potential is an important factor for quality of life. The optimization of NB minimal residual disease (MRD) detection in testicular tissue is crucial to evaluate the risk of malignant cell reintroduction. The first step in the present study was to assess the accuracy of reverse transcription-quantitative polymerase chain reaction (RT-qPCR) to detect tyrosine hydroxylase (TH), paired-like homeobox 2b (PHOX2B) and doublecortin (DCX) mRNA expression in frozen/thawed testicular tissues of patients with non-obstructive azoospermia (NOA) contaminated (in vitro model) with an increasing number of IMR-32 and SK-N-SH NB cells...
July 2017: Oncology Letters
https://www.readbyqxmd.com/read/28692130/the-index-case-is-not-enough-variation-among-individuals-groups-and-social-networks-modify-bacterial-transmission-dynamics
#5
Carl N Keiser, Noa Pinter-Wollman, Michael J Ziemba, Krishna S Kothamasu, Jonathan N Pruitt
1.The traits of the index case of an infectious disease outbreak, and the circumstances for their etiology, potentially influence the trajectory of transmission dynamics. However, these dynamics likely also depend on the traits of the individuals with whom the index case interacts. 2.We used the social spider Stegodyphus dumicola to test how the traits of the index case, group phenotypic composition, and group size interact to facilitate the transmission of a GFP-labeled cuticular bacterium. We also compared bacterial transmission across experimentally generated "daisy-chain" versus "star" networks of social interactions...
July 10, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28689994/rbp4-stra6-pathway-drives-cancer-stem-cell-maintenance-and-mediates-high-fat-diet-induced-colon-carcinogenesis
#6
Sheelarani Karunanithi, Liraz Levi, Jennifer DeVecchio, George Karagkounis, Ofer Reizes, Justin D Lathia, Matthew F Kalady, Noa Noy
The transmembrane protein, STRA6, functions as a vitamin A transporter and a cytokine receptor when activated by vitamin A-bound serum retinol binding protein 4 (RBP4). STRA6 activation transduces a JAK2-STAT3 signaling cascade and promotes tumorigenesis in a xenograft mouse model of colon cancer. We show here that RBP4 and STRA6 expression is associated with poor oncologic prognosis. Downregulating STRA6 or RBP4 in colon cancer cells decreased the fraction of cancer stem cells and their sphere and tumor initiation frequency...
July 3, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/28683114/evidence-for-arrogance-on-the-relative-importance-of-expertise-outcome-and-manner
#7
Maxim Milyavsky, Arie W Kruglanski, Marina Chernikova, Noa Schori-Eyal
Arrogant behavior is as old as human nature. Nonetheless, the factors that cause people to be perceived as arrogant have received very little research attention. In this paper, we focused on a typical manifestation of arrogance: dismissive behavior. In particular, we explored the conditions under which a person who dismissed advice would be perceived as arrogant. We examined two factors: the advisee's competence, and the manner in which he or she dismissed the advice. The effect of the advisee's competence was tested by manipulating two competence cues: relative expertise, and the outcome of the advice dismissal (i...
2017: PloS One
https://www.readbyqxmd.com/read/28678441/nebnext-direct-a-novel-rapid-hybridization-based-approach-for-the-capture-and-library-conversion-of-genomic-regions-of-interest
#8
Amy B Emerman, Sarah K Bowman, Andrew Barry, Noa Henig, Kruti M Patel, Andrew F Gardner, Cynthia L Hendrickson
Next-generation sequencing (NGS) is a powerful tool for genomic studies, translational research, and clinical diagnostics that enables the detection of single nucleotide polymorphisms, insertions and deletions, copy number variations, and other genetic variations. Target enrichment technologies improve the efficiency of NGS by only sequencing regions of interest, which reduces sequencing costs while increasing coverage of the selected targets. Here we present NEBNext Direct(®) , a hybridization-based, target-enrichment approach that addresses many of the shortcomings of traditional target-enrichment methods...
July 5, 2017: Current Protocols in Molecular Biology
https://www.readbyqxmd.com/read/28677060/assessment-of-patency-capsule-retention-using-mr-diffusion-weighted-imaging
#9
Eyal Klang, Uri Kopylov, Shomron Ben-Horin, Adi Lahat, Doron Yablecovitch, Noa Rozendorn, Rami Eliakim, Michal Marianne Amitai
OBJECTIVES: Evaluate the ability of MR diffusion-weighted imaging (DWI) to predict patency capsule retention in Crohn's disease (CD). METHODS: Clinical and imaging data were prospectively reviewed for 80 CD patients following patency capsule administration and MR-DWI under institutional review board (IRB) approval with informed consent. Two radiologists separately assessed the presence/absence of restricted diffusion in the distal ileum. Apparent diffusion coefficients (ADC) from three regions of interest on the ileal wall were averaged...
July 4, 2017: European Radiology
https://www.readbyqxmd.com/read/28676032/anticoagulation-in-tuberculosis-patients-not-achieving-a-therapeutic-range-with-vitamin-k-antagonists-a-systematic-review
#10
Marco Fiore, Alberto Enrico Maraolo, Paolo Chiodini, Claudio Cerchione, Ivan Gentile, Guglielmo Borgia, Maria Caterina Pace
Background Approximaly 3% of Tuberculosis (TB) patients have a venous thromboembolic events (VTE). The use of Vitamin K antagonists (VKAs), as anticoagulant, in patients receiving anti TB antimicrobials is often complicated by drug interactions, especially rifampicin. These patients require frequent monitoring of the International Normalized Ratio (INR), and it is reported that warfarin can not achieve a therapeutic INR. In such cases, abruptly stopping the rifampicin once the course of anti TB antimicrobials is not completed is potentially hazardous...
July 3, 2017: Cardiovascular & Hematological Disorders Drug Targets
https://www.readbyqxmd.com/read/28670430/sperm-retrieval-in-patients-with-klinefelter-syndrome-a-skewed-regression-model-analysis
#11
Mohammad Chehrazi, Abbas Rahimiforoushani, Marjan Sabbaghian, Keramat Nourijelyani, Mohammad Ali Sadighi Gilani, Mostafa Hoseini, Samira Vesali, Mehdi Yaseri, Ahad Alizadeh, Kazem Mohammad, Reza Omani Samani
BACKGROUND: The most common chromosomal abnormality due to non-obstructive azoospermia (NOA) is Klinefelter syndrome (KS) which occurs in 1-1.72 out of 500-1000 male infants. The probability of retrieving sperm as the outcome could be asymmetrically different between patients with and without KS, therefore logistic regression analysis is not a well-qualified test for this type of data. This study has been designed to evaluate skewed regression model analysis for data collected from microsurgical testicular sperm extraction (micro-TESE) among azoospermic patients with and without non-mosaic KS syndrome...
July 2017: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/28667676/cannabinoids-prevent-the-differential-long-term-effects-of-exposure-to-severe-stress-on-hippocampal-and-amygdala-dependent-memory-and-plasticity
#12
Noa Shoshan, Amir Segev, Hila Abush, Tomer Mizrachi Zer-Aviv, Irit Akirav
Exposure to excessive or uncontrolled stress is a major factor associated with various diseases including posttraumatic stress disorder (PTSD). The consequences of exposure to trauma are affected not only by aspects of the event itself, but also by the frequency and severity of trauma reminders. It was suggested that in PTSD, hippocampal-dependent memory is compromised while amygdala-dependent memory is strengthened. Several lines of evidence support the role of the endocannabinoid (eCB) system as a modulator of the stress response...
July 1, 2017: Hippocampus
https://www.readbyqxmd.com/read/28664509/hypertension-induced-synapse-loss-and-impairment-in-synaptic-plasticity-in-the-mouse-hippocampus-mimics-the-aging-phenotype-implications-for-the-pathogenesis-of-vascular-cognitive-impairment
#13
Zsuzsanna Tucsek, M Noa Valcarcel-Ares, Stefano Tarantini, Andriy Yabluchanskiy, Gábor Fülöp, Tripti Gautam, Albert Orock, Anna Csiszar, Ferenc Deak, Zoltan Ungvari
Strong epidemiological and experimental evidence indicates that hypertension has detrimental effects on the cerebral microcirculation and thereby promotes accelerated brain aging. Hypertension is an independent risk factor for both vascular cognitive impairment (VCI) and Alzheimer's disease (AD). However, the pathophysiological link between hypertension-induced cerebromicrovascular injury (e.g., blood-brain barrier disruption, increased microvascular oxidative stress, and inflammation) and cognitive decline remains elusive...
June 29, 2017: GeroScience
https://www.readbyqxmd.com/read/28654630/prognostic-value-of-subretinal-hyperreflective-material-in-neovascular-age-related-macular-degeneration-treated-with-bevacizumab
#14
Russell Pokroy, Michael Mimouni, Edward Barayev, Fani Segev, Noa Geffen, Arie Y Nemet, Ori Segal
PURPOSE: To study the correlation between subretinal hyperreflective material (SHRM) seen on spectral domain optical coherence tomography at baseline and visual outcomes after intravitreal bevacizumab injection in neovascular age-related macular degeneration. METHODS: Consecutive patient charts with treatment-naive center-involved neovascular age-related macular degeneration treated with 3 monthly intravitreal bevacizumab's, continued as needed, from 2011 to 2014 were reviewed...
June 20, 2017: Retina
https://www.readbyqxmd.com/read/28644436/the-lats1-and-lats2-tumor-suppressors-beyond-the-hippo-pathway
#15
REVIEW
Noa Furth, Yael Aylon
Proper cellular functionality and homeostasis are maintained by the convergent integration of various signaling cascades, which enable cells to respond to internal and external changes. The Dbf2-related kinases LATS1 and LATS2 (LATS) have emerged as central regulators of cell fate, by modulating the functions of numerous oncogenic or tumor suppressive effectors, including the canonical Hippo effectors YAP/TAZ, the Aurora mitotic kinase family, estrogen signaling and the tumor suppressive transcription factor p53...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28639438/body-composition-analysis-to-study-long-term-training-effects-in-elite-male-water-polo-athletes
#16
Giovanni Melchiorri, Valerio Viero, Roberto Sorge, Tamara Triossi, Alessandro Campagna, Stella L Volpe, Dalgisio Lecis, Virginia Tancredi, Angela Andreoli
BACKGROUND: Elite water polo athletes undergo heavy training programs throughout the year, but especially to prepare major competitions, such as the Olympics. Optimal athletic performance is a result of many factors, including proper management of the intensity and volume of training, nutrition and recovery between training sessions. When training is excessive in relation to recovery may occur non functional overreaching (NFO). NFO can degenerate into overtraining syndrome (OTS) resulting in a decrease in athletic performance, with likely changes in body weight and body composition...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28637085/successful-delivery-derived-from-cryopreserved-rare-human-spermatozoa-with-novel-cryopiece
#17
J Sun, W Chen, L Zhou, J Hu, Z Li, Z Zhang, Y Wu
Herein, we report the clinical outcomes following intracytoplasmic sperm injection (ICSI) with cryopiece cryopreserved rare human spermatozoa from severe male factor infertility patients. We established a novel cryopiece system on the basis of previous studies. In this study, 126 spermatozoa from four patients with non-obstructiveazoospermia (NOA) or severe oligozoospermia were stored in cryopiece and then thawed on the day of the oocyte retrieval, 88 (83%) spermatozoa were recovered with a 47.5% (38 of 80) motile rate...
June 21, 2017: Andrology
https://www.readbyqxmd.com/read/28632398/the-mitochondrial-protein-atlas-a-database-of-experimentally-verified-information-on-the-human-mitochondrial-proteome
#18
Noa Godin, Jerry Eichler
Given its central role in various biological systems, as well as its involvement in numerous pathologies, the mitochondrion is one of the best-studied organelles. However, although the mitochondrial genome has been extensively investigated, protein-level information remains partial, and in many cases, hypothetical. The Mitochondrial Protein Atlas (MPA; URL: lifeserv.bgu.ac.il/wb/jeichler/MPA ) is a database that provides a complete, manually curated inventory of only experimentally validated human mitochondrial proteins...
June 20, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28630412/the-challenges-of-predicting-pesticide-exposure-of-honey-bees-at-landscape-level
#19
Noa Simon-Delso, Gilles San Martin, Etienne Bruneau, Christine Delcourt, Louis Hautier
To evaluate the risks of pesticides for pollinators, we must not only evaluate their toxicity but also understand how pollinators are exposed to these xenobiotics in the field. We focused on this last point and modeled honey bee exposure to pesticides at the landscape level. Pollen pellet samples (n = 60) from 40 Belgian apiaries were collected from late July to October 2011 and underwent palynological and pesticide residue analyses. Areas of various crops around each apiary were measured at 4 spatial scales...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629974/the-effects-of-changes-in-object-location-on-object-identity-detection-a-simultaneous-eeg-fmri-study
#20
Ping Yang, Chenggui Fan, Min Wang, Noa Fogelson, Ling Li
Object identity and location are bound together to form a unique integration that is maintained and processed in visual working memory (VWM). Changes in task-irrelevant object location have been shown to impair the retrieval of memorial representations and the detection of object identity changes. However, the neural correlates of this cognitive process remain largely unknown. In the present study, we aim to investigate the underlying brain activation during object color change detection and the modulatory effects of changes in object location and VWM load...
June 16, 2017: NeuroImage
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