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https://www.readbyqxmd.com/read/28644436/the-lats1-and-lats2-tumor-suppressors-beyond-the-hippo-pathway
#1
REVIEW
Noa Furth, Yael Aylon
Proper cellular functionality and homeostasis are maintained by the convergent integration of various signaling cascades, which enable cells to respond to internal and external changes. The Dbf2-related kinases LATS1 and LATS2 (LATS) have emerged as central regulators of cell fate, by modulating the functions of numerous oncogenic or tumor suppressive effectors, including the canonical Hippo effectors YAP/TAZ, the Aurora mitotic kinase family, estrogen signaling and the tumor suppressive transcription factor p53...
June 23, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28639438/body-composition-analysis-to-study-long-term-training-effects-in-elite-male-water-polo-athletes
#2
Giovanni Melchiorri, Valerio Viero, Roberto Sorge, Tamara Triossi, Alessandro Campagna, Stella L Volpe, Dalgisio Lecis, Virginia Tancredi, Angela Andreoli
BACKGROUND: Elite water polo athletes undergo heavy training programs throughout the year, but especially to prepare major competitions, such as the Olympics. Optimal athletic performance is a result of many factors, including proper management of the intensity and volume of training, nutrition and recovery between training sessions. When training is excessive in relation to recovery may occur non functional overreaching (NFO). NFO can degenerate into overtraining syndrome (OTS) resulting in a decrease in athletic performance, with likely changes in body weight and body composition...
June 21, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28637085/successful-delivery-derived-from-cryopreserved-rare-human-spermatozoa-with-novel-cryopiece
#3
J Sun, W Chen, L Zhou, J Hu, Z Li, Z Zhang, Y Wu
Herein, we report the clinical outcomes following intracytoplasmic sperm injection (ICSI) with cryopiece cryopreserved rare human spermatozoa from severe male factor infertility patients. We established a novel cryopiece system on the basis of previous studies. In this study, 126 spermatozoa from four patients with non-obstructiveazoospermia (NOA) or severe oligozoospermia were stored in cryopiece and then thawed on the day of the oocyte retrieval, 88 (83%) spermatozoa were recovered with a 47.5% (38 of 80) motile rate...
June 21, 2017: Andrology
https://www.readbyqxmd.com/read/28632398/the-mitochondrial-protein-atlas-a-database-of-experimentally-verified-information-on-the-human-mitochondrial-proteome
#4
Noa Godin, Jerry Eichler
Given its central role in various biological systems, as well as its involvement in numerous pathologies, the mitochondrion is one of the best-studied organelles. However, although the mitochondrial genome has been extensively investigated, protein-level information remains partial, and in many cases, hypothetical. The Mitochondrial Protein Atlas (MPA; URL: lifeserv.bgu.ac.il/wb/jeichler/MPA ) is a database that provides a complete, manually curated inventory of only experimentally validated human mitochondrial proteins...
June 20, 2017: Journal of Computational Biology: a Journal of Computational Molecular Cell Biology
https://www.readbyqxmd.com/read/28630412/the-challenges-of-predicting-pesticide-exposure-of-honey-bees-at-landscape-level
#5
Noa Simon-Delso, Gilles San Martin, Etienne Bruneau, Christine Delcourt, Louis Hautier
To evaluate the risks of pesticides for pollinators, we must not only evaluate their toxicity but also understand how pollinators are exposed to these xenobiotics in the field. We focused on this last point and modeled honey bee exposure to pesticides at the landscape level. Pollen pellet samples (n = 60) from 40 Belgian apiaries were collected from late July to October 2011 and underwent palynological and pesticide residue analyses. Areas of various crops around each apiary were measured at 4 spatial scales...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28629974/the-effects-of-changes-in-object-location-on-object-identity-detection-a-simultaneous-eeg-fmri-study
#6
Ping Yang, Chenggui Fan, Min Wang, Noa Fogelson, Ling Li
Object identity and location are bound together to form a unique integration that is maintained and processed in visual working memory (VWM). Changes in task-irrelevant object location have been shown to impair the retrieval of memorial representations and the detection of object identity changes. However, the neural correlates of this cognitive process remain largely unknown. In the present study, we aim to investigate the underlying brain activation during object color change detection and the modulatory effects of changes in object location and VWM load...
June 16, 2017: NeuroImage
https://www.readbyqxmd.com/read/28628699/closing-the-medication-assisted-treatment-gap-for-youth-with-opioid-use-disorder
#7
Brendan Saloner, Kenneth A Feder, Noa Krawczyk
No abstract text is available yet for this article.
June 19, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28627471/phospholipid-drug-conjugates-as-a-novel-oral-drug-targeting-approach-for-the-treatment-of-inflammatory-bowel-disease
#8
Arik Dahan, Milica Markovic, Svetlana Epstein, Noa Cohen, Ellen M Zimmermann, Aaron Aponick, Shimon Ben-Shabat
The enzyme phospholipase A2 (PLA2) is overexpressed in the inflamed intestine in inflammatory bowel disease (IBD) patients, and in this work we aimed to exploit PLA2 as a prodrug-activating enzyme for a novel PL-drug conjugate, thereby liberating the free drug specifically in the targeted diseased tissue(s). The proposed prodrug contains a drug moiety covalently bound through a linker to the sn-2 position of a phospholipid (PL). The NSAID diclofenac was used as model molecule, and four different linker lengths (2, 4, 6 and 8 -CH2 units) were studied...
June 13, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28622530/brain-network-dynamics-in-the-human-articulatory-loop
#9
Masaaki Nishida, Anna Korzeniewska, Nathan E Crone, Goichiro Toyoda, Yasuo Nakai, Noa Ofen, Erik C Brown, Eishi Asano
OBJECTIVE: The articulatory loop is a fundamental component of language function, involved in the short-term buffer of auditory information followed by its vocal reproduction. We characterized the network dynamics of the human articulatory loop, using invasive recording and stimulation. METHODS: We measured high-gamma activity70-110 Hz recorded intracranially when patients with epilepsy either only listened to, or listened to and then reproduced two successive tones by humming...
May 17, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28616821/re-irradiation-after-gross-total-resection-of-recurrent-glioblastoma-spatial-pattern-of-recurrence-and-a-review-of-the-literature-as-a-basis-for-target-volume-definition
#10
Christoph Straube, Greeshma Elpula, Jens Gempt, Julia Gerhardt, Stefanie Bette, Claus Zimmer, Friederike Schmidt-Graf, Bernhard Meyer, Stephanie E Combs
BACKGROUND: Currently, patients with gross total resection (GTR) of recurrent glioblastoma (rGBM) undergo adjuvant chemotherapy or are followed up until progression. Re-irradiation, as one of the most effective treatments in macroscopic rGBM, is withheld in this situation, as uncertainties about the pattern of re-recurrence, the target volume, and also the efficacy of early re-irradiation after GTR exist. METHODS: Imaging and clinical data from 26 consecutive patients with GTR of rGBM were analyzed...
June 14, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28614558/burnout-there-s-an-app-for-that-helping-physicians-deal-with-job-related-stress
#11
Noa Holoshitz, Samuel Wann
No abstract text is available yet for this article.
June 14, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28614535/should-azoospermic-patients-with-varicocele-disease-undergo-surgery-to-recover-fertility
#12
Leonardo de Souza Alves, Francisco Batista de Oliveira
Introduction: Varicocele disease is well-known cause of infertility in men. The presence of spermatic varices veins create a hostile environment to spermatogenesis. It results in reduced quality of the sperm production and in some cases can determine a total absence of sperm. The varicocelectomy procedure in patients with non-obstructive azoospermia (NOA) can raise the rates of sperm in the semen analysis. A positive rate for sperm, even if very low, may be sufficient to enable the capture of sperm intended for in-vitro fertilization without the use of donor sperm...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28610384/saying-goodbye-to-monotypy-in-the-poorly-known-genus-austrophyto-lopes-1989-diptera-sarcophagidae-new-diagnosis-and-description-of-two-new-species
#13
Pablo Ricardo Mulieri
The Argentinean endemic genus Austrophyto Lopes, 1989 is revised. The diagnosis of the genus is revised and circumscribed, especially focusing on the configuration of the male terminalia. The male of Austrophyto cordobensis is redescribed and two new species, A. noa sp. nov. and A. mariluisi sp. nov., are described. Structures of the male terminalia of all species are documented and compared. A key to the adult males of the species is presented. The genus Austrophyto Lopes is now represented by three species distributed in north-western Argentina...
May 15, 2017: Zootaxa
https://www.readbyqxmd.com/read/28607180/p53-is-essential-for-dna-methylation-homeostasis-in-na%C3%A3-ve-embryonic-stem-cells-and-its-loss-promotes-clonal-heterogeneity
#14
Ayala Tovy, Adam Spiro, Ryan McCarthy, Zohar Shipony, Yael Aylon, Kendra Alton, Elena Ainbinder, Noa Furth, Amos Tanay, Michelle Barton, Moshe Oren
DNA methylation is a key regulator of embryonic stem cell (ESC) biology, dynamically changing between naïve, primed, and differentiated states. The p53 tumor suppressor is a pivotal guardian of genomic stability, but its contributions to epigenetic regulation and stem cell biology are less explored. We report that, in naïve mouse ESCs (mESCs), p53 restricts the expression of the de novo DNA methyltransferases Dnmt3a and Dnmt3b while up-regulating Tet1 and Tet2, which promote DNA demethylation. The DNA methylation imbalance in p53-deficient (p53(-/-)) mESCs is the result of augmented overall DNA methylation as well as increased methylation landscape heterogeneity...
June 12, 2017: Genes & Development
https://www.readbyqxmd.com/read/28605766/genehancer-genome-wide-integration-of-enhancers-and-target-genes-in-genecards
#15
Simon Fishilevich, Ron Nudel, Noa Rappaport, Rotem Hadar, Inbar Plaschkes, Tsippi Iny Stein, Naomi Rosen, Asher Kohn, Michal Twik, Marilyn Safran, Doron Lancet, Dana Cohen
http://www.genecards.org/.
January 1, 2017: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/28600773/highly-specific-ligation-dependent-microarray-detection-of-single-nucleotide-polymorphisms
#16
Noa Wolff, Ivan Barišicʹ
The fast detection and characterization of pathogens are essential for an efficient treatment of infectious diseases. However, the development of improved and reliable diagnostic methods is still an ongoing process because not only pathogens but also their antibiotic resistances have to be identified. The gold standard today is, however, a cultivation-based characterization approach, which takes days until results can be evaluated. In patients with, for example, severe sepsis, the diagnostic test duration is a very critical parameter because a delay of treatment optimization increases the mortality rate significantly...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28591632/bread-affects-clinical-parameters-and-induces-gut-microbiome-associated-personal-glycemic-responses
#17
Tal Korem, David Zeevi, Niv Zmora, Omer Weissbrod, Noam Bar, Maya Lotan-Pompan, Tali Avnit-Sagi, Noa Kosower, Gal Malka, Michal Rein, Jotham Suez, Ben Z Goldberg, Adina Weinberger, Avraham A Levy, Eran Elinav, Eran Segal
Bread is consumed daily by billions of people, yet evidence regarding its clinical effects is contradicting. Here, we performed a randomized crossover trial of two 1-week-long dietary interventions comprising consumption of either traditionally made sourdough-leavened whole-grain bread or industrially made white bread. We found no significant differential effects of bread type on multiple clinical parameters. The gut microbiota composition remained person specific throughout this trial and was generally resilient to the intervention...
June 6, 2017: Cell Metabolism
https://www.readbyqxmd.com/read/28589652/losartan-for-the-nephropathy-of-sickle-cell-anemia-a-phase-2-multi-center-trial
#18
Charles T Quinn, Santosh L Saraf, Victor R Gordeuk, Courtney D Fitzhugh, Susan E Creary, Prasad Bodas, Alex George, Ashok B Raj, Alecia C Nero, Catherine E Terrell, Lisa McCord, Adam Lane, Hans C Ackerman, Yu Yang, Omar Niss, Michael D Taylor, Prasad Devarajan, Punam Malik
Nephropathy is a common and progressive complication of sickle cell anemia (SCA). In SCA mice, we found that hyperangiotensinemia in the absence of hypertension underlies nephropathy, and its downregulation by losartan, an angiotensin-II-receptor-1 blocker, reduced albuminuria and progression of nephropathy. Therefore, we performed a phase-2 trial of oral losartan, given for 6 months, to explore whether it reduced albuminuria in children and adults with SCA. Participants were allocated to groups defined by class of baseline urinary albumin-to-creatinine ratio (UACR): no albuminuria (NoA), microalbuminuria (MicroA), and macroalbuminuria (MacroA)...
June 7, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28583038/carfilzomib-as-salvage-therapy-in-waldenstrom-macroglobulinemia-a-case-series
#19
David H Vesole, Joshua Richter, Noa Biran, Laura McBride, Palka Anand, Mei Huang, Anita-Zahlten Kumeli, Zandra Klippel, Karim Iskander, David S Siegel
No abstract text is available yet for this article.
June 5, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28575815/cardiac-disease-induced-ptsd-cdi-ptsd-a-systematic-review
#20
REVIEW
Noa Vilchinsky, Karni Ginzburg, Keren Fait, Edna B Foa
The goal of the current systematic review was to provide an overview of the findings in the field of Cardiac-Disease-Induced Posttraumatic Stress Disorder (CDI-PTSD) in order to establish CDI-PTSD as a valid diagnostic entity for a wide spectrum of cardiac diseases and related medical procedures. In accordance with PRISMA guidelines, we conducted a systematic electronic literature search. Of the 3202 citations identified, 150 studies meeting the selection criteria were reviewed. Our main findings were that the prevalence of CDI-PTSD ranged between 0% and 38% (averaging at 12%) and was highly dependent on the assessment tool used...
July 2017: Clinical Psychology Review
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