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https://www.readbyqxmd.com/read/28342999/hippocampal-ca3-dentate-gyrus-volume-uniquely-linked-to-improvement-in-associative-memory-from-childhood-to-adulthood
#1
Ana M Daugherty, Robert Flinn, Noa Ofen
Associative memory develops into adulthood and critically depends on the hippocampus. The hippocampus is a complex structure composed of subfields that are functionally-distinct, and anterior-posterior divisions along the length of the hippocampal horizontal axis that may also differ by cognitive correlates. Although each of these aspects has been considered independently, here we evaluate their relative contributions as correlates of age-related improvement in memory. Volumes of hippocampal subfields (subiculum, CA1-2, CA3-dentate gyrus) and anterior-posterior divisions (hippocampal head, body, tail) were manually segmented from high-resolution proton density-weighted images in a sample of healthy participants (age 8-25 years)...
March 22, 2017: NeuroImage
https://www.readbyqxmd.com/read/28342926/causes-and-clinical-features-of-infertile-men-with-non-obstructive-azoospermia-and-histopathological-diagnosis-of-hypospermatogenesis
#2
Yu-Sheng Cheng, Chun-Wun Lu, Tsung-Yen Lin, Pei-Yu Lin, Yung-Ming Lin
OBJECTIVE: To analyze the causes and the clinical features of infertile men with non-obstructive azoospermia (NOA) and hypospermatogenesis (HS). METHODS: This retrospective cohort study included 100 patients with NOA and HS and eight patients with obstructive azoospermia and normal spermatogenesis. The severity of HS was subdivided into three groups (mild, moderate, and severe) based on spermatogenic score. Data of history, physical findings, serum hormone profiles, genetic studies and sperm retrieval rate (SRR) were collected...
March 22, 2017: Urology
https://www.readbyqxmd.com/read/28339042/immunomodulatory-effects-in-workers-exposed-to-naturally-occurring-asbestos-fibers
#3
Caterina Ledda, Chiara Costa, Serena Matera, Beatrice Puglisi, Valentina Costanzo, Massimo Bracci, Concettina Fenga, Venerando Rapisarda, Carla Loreto
Natural asbestiform fibers are defined 'naturally occurring asbestos' (NOA) and refer to the mineral as a natural component of soils or rocks. The release of NOA fibers into the air from rocks or soils by routine human activities or natural weathering processes represents a risk for human beings. Fluoro-edenite (FE) is a NOA fiber detected in the benmoreitic lava in the area of Biancavilla, South-west slope of Mt. Etna. The aim of the present study was to investigate FE immunotoxicity pathways in a group of 38 occupationally exposed construction workers, in order to find any biological markers of its effect...
March 24, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28335844/heart-failure-induced-brain-injury
#4
REVIEW
Ofer Havakuk, Kevin S King, Luanda Grazette, Andrew J Yoon, Michael Fong, Noa Bregman, Uri Elkayam, Robert A Kloner
Heart failure (HF) is a systemic illness with grave implications for bodily functions. The brain, among other vital organs, often suffers insults as a result of HF, and both anatomic and functional brain abnormalities were found in the HF population. This injury was demonstrated across a wide range of clinical conditions and cardiac functions and was shown to affect patients' outcomes. Although reduced cardiac output and high burden of cardiovascular risk factors are the prevailing explanations for these findings, there are data showing the involvement of neurohormonal, nutritional, and inflammatory mechanisms in this complex process...
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28331619/processing-and-selection-of-surgically-retrieved-sperm-for-icsi-a-review
#5
Greta Verheyen, Biljana Popovic-Todorovic, Herman Tournaye
Although the technique of intracytoplasmic sperm injection (ICSI) has been a revolution in the alleviation of male infertility, the use of testicular sperm for ICSI was a formerly unseen breakthrough in the treatment of the azoospermic man with primary testicular failure. At the clinical level, different procedures of testicular sperm retrieval (conventional TESE, micro-TESE, FNA/TESA, MESA, PESA) are being performed, the choice is mainly based on the cause of azoospermia (obstructive versus non-obstructive) and the surgeon's skills...
2017: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/28319698/the-combined-effect-of-reduced-fossil-fuel-consumption-and-increasing-biomass-combustion-on-athens-air-quality-as-inferred-from-long-term-co-measurements
#6
Myrto Gratsea, Eleni Liakakou, Nikos Mihalopoulos, Anastasios Adamopoulos, Eirini Tsilibari, Evangelos Gerasopoulos
To evaluate the role of biomass burning emissions, and in particular of residential wood heating, as a result of the economic recession in Greece, carbon monoxide (CO) atmospheric concentrations from five (5) stations of the National Air Pollution Monitoring Network in Athens, spanning the period 2000-2015, in conjunction with black carbon (BC) concentrations from the NOA (National Observatory of Athens) station at Thissio were analysed. The contribution of the different sources to the diurnal cycle of these two pollutants is clear, resulting to a morning peak, mainly due to traffic, and a late evening peak attributed both to fossil fuel (traffic plus central heating) and biomass combustion...
March 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28317224/pharmacotherapy-for-the-treatment-of-aggression-in-pediatric-and-adolescent-patients-with-autism-spectrum-disorder-comorbid-attention-deficit-hyperactivity-disorder-a-questionnaire-survey-of-571-psychiatrists
#7
Kazuhiko Yamamuro, Noa Tsujii, Toyosaku Ota, Toshifumi Kishimoto, Junzo Iida
AIMS: Both attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are frequently accompanied by serious aggression that requires psychiatric treatment. However, little is known about the experiences psychiatrists have had using pharmacotherapy to treat aggression in patients who have both ASD and ADHD (ASD/ADHD). The purpose of this study was to examine the experiences of Japanese child and adolescent psychiatrists in prescribing medication for aggression in patients with ASD/ADHD...
March 20, 2017: Psychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/28315146/attempts-to-improve-human-ovarian-transplantation-outcomes-of-needle-immersed-vitrification-and-slow-freezing-by-host-and-graft-treatments
#8
Ronit Abir, Benjamin Fisch, Noa Fisher, Nivin Samara, Galit Lerer-Serfaty, Roei Magen, Michal Herman-Edelstein, Avi Ben-Haroush, Anat Stein, Raoul Orvieto
PURPOSE: To investigate if needle-immersed vitrification or slow-freezing yields better implantation results for human ovarian tissue and which method benefits more when combined with the "improvement protocol" of host melatonin treatment and graft incubation with biological glue + vitamin E + vascular endothelial growth factor-A. METHODS: Human ovarian tissue was preserved by needle-immersed vitrification or slow-freezing and transplanted into immunodeficient mice, either untreated (groups A and C, respectively) or treated with the improvement protocol (groups B and D, respectively)...
March 18, 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28299642/cerebromicrovascular-dysfunction-predicts-cognitive-decline-and-gait-abnormalities-in-a-mouse-model-of-whole-brain-irradiation-induced-accelerated-brain-senescence
#9
Zoltan Ungvari, Stefano Tarantini, Peter Hertelendy, M Noa Valcarcel-Ares, Gabor A Fülöp, Sreemathi Logan, Tamas Kiss, Eszter Farkas, Anna Csiszar, Andriy Yabluchanskiy
Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies. However, it also promotes accelerated senescence in healthy tissues and leads to progressive cognitive dysfunction in up to 50% of tumor patients surviving long term after treatment, due to γ-irradiation-induced cerebromicrovascular injury. Moment-to-moment adjustment of cerebral blood flow (CBF) via neuronal activity-dependent cerebromicrovascular dilation (functional hyperemia) has a critical role in maintenance of healthy cognitive function...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28296403/distinct-roles-for-interfacial-hydration-in-site-specific-dna-recognition-by-ets-family-transcription-factors
#10
Suela Xhani, Shingo Esaki, Kenneth Huang, Noa Erlitzki, Gregory M K Poon
The ETS family of transcription factors is a functionally heterogeneous group of gene regulators that share a structurally conserved, eponymous DNA-binding domain. Unlike other ETS homologs, such as Ets-1, DNA recognition by PU.1 is highly sensitive to its osmotic environment due to excess interfacial hydration in the complex. To interrogate interfacial hydration in the two homologs, we mutated a highly conserved tyrosine residue, which is exclusively engaged in coordinating a well-defined water contact between the protein and DNA among ETS proteins, to phenylalanine...
March 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28295976/insulin-like-growth-factor-1-deficiency-exacerbates-hypertension-induced-cerebral-microhemorrhages-in-mice-mimicking-the-aging-phenotype
#11
Stefano Tarantini, Noa M Valcarcel-Ares, Andriy Yabluchanskiy, Zsolt Springo, Gabor A Fulop, Nicole Ashpole, Tripti Gautam, Cory B Giles, Jonathan D Wren, William E Sonntag, Anna Csiszar, Zoltan Ungvari
Clinical and experimental studies show that aging exacerbates hypertension-induced cerebral microhemorrhages (CMHs), which progressively impair neuronal function. There is growing evidence that aging promotes insulin-like growth factor 1 (IGF-1) deficiency, which compromises multiple aspects of cerebromicrovascular and brain health. To determine the role of IGF-1 deficiency in the pathogenesis of CMHs, we induced hypertension in mice with liver-specific knockdown of IGF-1 (Igf1(f/f)  + TBG-Cre-AAV8) and control mice by angiotensin II plus l-NAME treatment...
March 14, 2017: Aging Cell
https://www.readbyqxmd.com/read/28293085/octogenarian-patients-with-colorectal-cancer-characterizing-an-emerging-clinical-entity
#12
Hadar Goldvaser, Noa Katz Shroitman, Irit Ben-Aharon, Ofer Purim, Yulia Kundel, Daniel Shepshelovich, Tzippy Shochat, Aaron Sulkes, Baruch Brenner
AIM: To characterize colorectal cancer (CRC) in octogenarians as compared with younger patients. METHODS: A single-center, retrospective cohort study which included patients diagnosed with CRC at the age of 80 years or older between 2008-2013. A control group included consecutive patients younger than 80 years diagnosed with CRC during the same period. Clinicopathological characteristics, treatment and outcome were compared between the groups. Fisher's exact test was used for dichotomous variables and χ(2) was used for variables with more than two categories...
February 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28291534/ptpn22-1123g-c-polymorphism-and-anti-cyclic-citrullinated-protein-antibodies-in-rheumatoid-arthritis
#13
José Francisco Muñoz-Valle, Jorge Ramón Padilla-Gutiérrez, Jorge Hernández-Bello, Yeniley Ruiz-Noa, Yeminia Valle, Claudia Azucena Palafox-Sánchez, Isela Parra-Rojas, Sergio Ramón Gutiérrez-Ureña, Hector Rangel-Villalobos
BACKGROUND AND OBJECTIVES: The protein tyrosine phosphatase non-receptor type 22 (PTPN22) gene encodes an important negative regulator of T-cell activation, lymphoid-specific phosphatase -Lyp- and has been associated with different autoimmune disorders. The PTPN22 -1123G>C polymorphism appears to affect the transcriptional control of this gene, but to date, the biological significance of this polymorphisms on rheumatoid arthritis (RA) risk remains unknown. We evaluate the association of PTPN22 -1123G>C polymorphism with anti-cyclic citrullinated protein antibodies (anti-CCP) and risk for RA in population from Western Mexico...
March 10, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28277915/termination-of-pregnancy-due-to-fetal-abnormalities-performed-after-32-weeks-gestation-survey-of-57-fetuses-from-a-single-medical-center
#14
Noa Feldman, Yaakov Melcer, Edward Hod, Orna Levinsohn-Tavor, Ran Svirsky, Ron Maymon
OBJECTIVE: To assess fetal abnormalities leading to very late termination of pregnancy performed after 32 weeks' gestation (VLTOP). METHOD: The study population included all pregnant women with singleton pregnancy that underwent VLTOP in our institute because of fetal indications between the years 1998 and 2015. RESULTS: Fifty-seven cases (2.0%) were at ≥32 week's gestation and are the subjects of the current study. Our VLTOP cases were subdivided into four categories according to the sequence of events that led to the decision for VLTOP: (1) No routine prenatal screening with an incidental fetal finding discovered after 32 weeks' gestation (9 fetuses ∼16%); (2) Routine early prenatal care raised suspicion of abnormalities, and the final diagnosis was established by additional tests (8 fetuses, ∼14%); (3) Developmental findings detected during the 3(rd) trimester (21 fetuses; ∼37%), and (4) fetal abnormalities that could have been detected earlier during pregnancy (19 fetuses; ∼33%)...
February 21, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28269726/using-computational-phantoms-to-improve-delivery-of-tumor-treating-fields-ttfields-to-patients
#15
Ze'ev Bomzon, Hadas Sara Hershkovich, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Anders R Korshoej, Uri Weinberg, Cornelia Wenger, Pedro Miranda, Yoram Wasserman, Eilon D Kirson, Yoram
This paper reviews the state-of-the-art in simulation-based studies of Tumor Treating Fields (TTFields) and highlights major aspects of TTFields in which simulation-based studies could affect clinical outcomes. A major challenge is how to simulate multiple scenarios rapidly for TTFields delivery. Overcoming this challenge will enable a better understanding of how TTFields distribution is correlated with disease progression, leading to better transducer array designs and field optimization procedures, ultimately improving patient outcomes...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28268799/first-steps-to-creating-a-platform-for-high-throughput-simulation-of-ttfields
#16
Hadas Sara Hershkovich, Zeev Bomzon, Cornelia Wenger, Noa Urman, Aafia Chaudhry, Dario Garcia-Carracedo, Eilon D Kirson, Uri Weinberg, Yoram Wassermann, Yoram Palti
Tumor Treating Fields (TTFields) are low intensity alternating electric fields in the 100-500 KHz frequency range that are known to have an anti-mitotic effect on cancerous cells. In the USA, TTFields are approved by the Food and Drug Administration (FDA) for the treatment of glioblastoma (GBM) in both the newly diagnosed and recurrent settings. Optimizing treatment with TTFields requires a deep understanding of how TTFields distribute within the brain. To address this issue, simulations using realistic head models have been performed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28262470/association-of-early-onset-myasthenia-gravis-in-newfoundland-dogs-with-the-canine-major-histocompatibility-complex-class-i
#17
Zena Wolf, Karen Vernau, Noa Safra, G Diane Shelton, Jason King, Joseph Owen, Kalie Weich, Danika Bannasch
Acquired Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder whose development in humans has been associated with the Major Histocompatibility Complex (MHC) or Human Leukocyte Antigen (HLA). There is a form of early onset MG (EOMG) in Newfoundland dogs that mimics the clinical presentation in humans and appears to have familial inheritance. Genotyping of three classical Dog Leukocyte Antigen (DLA) class II genes, DLA-DRB1, DLA-DQA1 and DLA-DQB1, in 16 Newfoundlands with EOMG and 46 unaffected Newfoundlands, identified DLA-DQB1 *00301 (p-value = 0...
January 30, 2017: Neuromuscular Disorders: NMD
https://www.readbyqxmd.com/read/28258807/medication-assisted-treatment-for-adolescents-in-specialty-treatment-for-opioid-use-disorder
#18
Kenneth A Feder, Noa Krawczyk, Brendan Saloner
PURPOSE: The American Academy of Pediatrics recently recommended that pediatricians consider medication-assisted treatment (MAT) for adolescents with severe opioid use disorders. Little is known about adolescents' current use of MAT. METHODS: We use data on episodes of specialty treatment for heroin or opioid use (n = 139,092) from a database of publicly funded treatment programs in the U.S. We compare the proportions of adolescents and adults who received MAT, first using unadjusted comparison of proportions, then using logistic regression to adjust for potential confounders...
February 28, 2017: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
https://www.readbyqxmd.com/read/28255694/analysis-of-microtubules-and-microtubule-organizing-center-at-the-immune-synapse
#19
Noelia Blas-Rus, Eugenio Bustos-Morán, Francisco Sánchez-Madrid, Noa B Martín-Cófreces
The immune synapse (IS) is a specialized structure that enables cell-cell communication between immune cells. As such, it involves direct cell-to-cell contact. It is sustained by cytoskeletal components that allow the intracellular polarization of different organelles and the surface re-organization of signaling and adhesion receptors. The tubulin-based cytoskeleton is a key player in IS formation and signaling. We describe methods to analyze through Western blot and microscopy analysis the polarization to the IS of the centrosome, also known as microtubule-organizing center (MTOC), the dynamics of microtubule growth and polymerization from the MTOC to the IS and the activation of signaling molecules...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28253280/the-cyanobacterial-metabolite-nocuolin-a-is-a-natural-oxadiazine-that-triggers-apoptosis-in-human-cancer-cells
#20
Kateřina Voráčová, Jan Hájek, Jan Mareš, Petra Urajová, Marek Kuzma, José Cheel, Andreas Villunger, Alexandra Kapuscik, Marcel Bally, Petr Novák, Martin Kabeláč, Gerhard Krumschnabel, Martin Lukeš, Ludmila Voloshko, Jiří Kopecký, Pavel Hrouzek
Oxadiazines are heterocyclic compounds containing N-N-O or N-N-C-O system within a six membered ring. These structures have been up to now exclusively prepared via organic synthesis. Here, we report the discovery of a natural oxadiazine nocuolin A (NoA) that has a unique structure based on 1,2,3-oxadiazine. We have identified this compound in three independent cyanobacterial strains of genera Nostoc, Nodularia, and Anabaena and recognized the putative gene clusters for NoA biosynthesis in their genomes. Its structure was characterized using a combination of NMR, HRMS and FTIR methods...
2017: PloS One
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