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https://www.readbyqxmd.com/read/28818702/the-effects-of-cannabinoid-receptors-activation-and-glucocorticoid-receptors-deactivation-in-the-amygdala-and-hippocampus-on-the-consolidation-of-a-traumatic-event
#1
Noa Shoshan, Irit Akirav
Ample evidence demonstrates that fear learning contributes significantly to many anxiety pathologies including post-traumatic stress disorder (PTSD). The endocannabinoid (eCB) system may offer therapeutic benefits for PTSD and it is a modulator of the hypothalamic pituitary adrenal (HPA) axis. Here we compared the separated and combined effects of blocking glucocorticoid receptors (GRs) using the GR antagonist RU486 and enhancing CB1r signaling using the CB1/2 receptor agonist WIN55,212-2 in the CA1 and basolateral amygdala (BLA) on the consolidation of traumatic memory...
August 14, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/28818628/a-prospective-multicentre-study-of-the-epidemiology-and-outcomes-of-bloodstream-infection-in-cirrhotic-patients
#2
Michele Bartoletti, Maddalena Giannella, Russell Lewis, Paolo Caraceni, Sara Tedeschi, Mical Paul, Christoph Schramm, Tony Bruns, Manuela Merli, Nazaret Cobos-Trigueros, Elena Seminari, Pilar Retamar, Patricia Muñoz, Mario Tumbarello, Patrizia Burra, Maria Torrani Cerenzia, Bruno Barsic, Ester Calbo, Alberto Enrico Maraolo, Nicola Petrosillo, Maria Angeles Galan-Ladero, Giampiero D'Offizi, Noa Bar Sinai, Jesus Rodríguez-Baño, Gabriella Verucchi, Mauro Bernardi, Pierluigi Viale
OBJECTIVE: The aim of this study was to describe the current epidemiology of BSI in patients with cirrhosis, analyse predictors of 30-day mortality, and risk factors for antibiotic resistance. METHODS: Cirrhotic patients developing a BSI episode were prospectively included at 19 centres in five countries from September 2014 to December 2015. The discrimination of mortality risk scores for 30-day mortality were compared by area under the receiver operator-risk and Cox-regression models...
August 14, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28815147/triangulating-methodologies-from-software-medicine-and-human-factors-industries-to-measure-usability-and-clinical-efficacy-of-medication-data-visualization-in-an-electronic-health-record-system
#3
Bora Chang, Manoj Kanagaraj, Ben Neely, Noa Segall, Erich Huang
Within the last decade, use of Electronic Health Record (EHR) systems has become intimately integrated into healthcare practice in the United States. However, large gaps remain in the study of clinical usability and require rigorous and innovative approaches for testing usability principles. In this study, validated tools from the core functions that EHRs serve-software, medicine and human factors-were combined to holistically understand and objectively measure usability of medication data displays. The first phase of this study included 132 medical trainee participants who were randomized to one of two simulated EHR environments with either a medication list or a medication timeline visualization...
2017: AMIA Summits on Translational Science Proceedings
https://www.readbyqxmd.com/read/28814394/dynamics-of-intrapericardial-and-extrapericardial-fat-tissues-during-long-term-dietary-induced-moderate-weight-loss
#4
Gal Tsaban, Arik Wolak, Hila Avni-Hassid, Yftach Gepner, Ilan Shelef, Yaakov Henkin, Dan Schwarzfuchs, Noa Cohen, Nitzan Bril, Michal Rein, Dana Serfaty, Shira Kenigsbuch, Lilac Tene, Hila Zelicha, Anat Yaskolka-Meir, Oded Komy, Avital Bilitzky, Yoash Chassidim, Uta Ceglarek, Michael Stumvoll, Matthias Blüher, Joachim Thiery, Dror Dicker, Assaf Rudich, Meir J Stampfer, Iris Shai
Background: In view of evidence linking pericardial fat accumulation with increased cardiovascular disease risk, strategies to reduce its burden are needed. Data comparing the effects of specific long-term dietary interventions on pericardial fat tissue mobilization are sparse.Objective: We sought to evaluate intrapericardial-fat (IPF) and extrapericardial-fat (EPF) changes during weight-loss interventions by different dietary regimens.Design: During 18 mo of a randomized controlled trial, we compared a Mediterranean/low-carbohydrate (MED/LC) diet plus 28 g walnuts/d with a calorically equal low-fat (LF) diet among randomly assigned participants with moderate abdominal obesity...
August 16, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28812703/the-impact-of-architecture-on-collective-behaviour
#5
Noa Pinter-Wollman, Stephen M Fiore, Guy Theraulaz
No abstract text is available yet for this article.
March 27, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28807351/cost-effectiveness-of-nivolumab-in-advanced-renal-cell-carcinoma
#6
Michal Sarfaty, Moshe Leshno, Noa Gordon, Assaf Moore, Victoria Neiman, Eli Rosenbaum, Daniel A Goldstein
BACKGROUND: In recent years, new drugs have been introduced for second-line treatment of advanced renal cell carcinoma (RCC). Nivolumab increases overall survival and is associated with less toxicity compared to everolimus in this setting according to the CheckMate 025 study. However, because of the high cost of nivolumab, there is a need to define its value by considering both efficacy and cost. OBJECTIVE: To estimate the cost effectiveness of nivolumab for second-line treatment of advanced RCC from the US payer perspective...
August 11, 2017: European Urology
https://www.readbyqxmd.com/read/28798218/imaging-biomarkers-for-adult-medulloblastomas-genetic-entities-may-be-identified-by-their-mr-imaging-radiophenotype
#7
V C Keil, M Warmuth-Metz, C Reh, S J Enkirch, C Reinert, D Beier, D T W Jones, T Pietsch, H H Schild, E Hattingen, P Hau
BACKGROUND AND PURPOSE: The occurrence of medulloblastomas in adults is rare; nevertheless, these tumors can be subdivided into genetic and histologic entities each having distinct prognoses. This study aimed to identify MR imaging biomarkers to classify these entities and to uncover differences in MR imaging biomarkers identified in pediatric medulloblastomas. MATERIALS AND METHODS: Eligible preoperative MRIs from 28 patients (11 women; 22-53 years of age) of the Multicenter Pilot-study for the Therapy of Medulloblastoma of Adults (NOA-7) cohort were assessed by 3 experienced neuroradiologists...
August 10, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28790957/unrecognized-undiagnosed-and-untreated-cardiac-disease-induced-ptsd-among-patients-partners
#8
Noa Vilchinsky
No abstract text is available yet for this article.
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28790300/agonist-induced-dimer-dissociation-as-a-macromolecular-step-in-g-protein-coupled-receptor-signaling
#9
Julian Petersen, Shane C Wright, David Rodríguez, Pierre Matricon, Noa Lahav, Aviv Vromen, Assaf Friedler, Johan Strömqvist, Stefan Wennmalm, Jens Carlsson, Gunnar Schulte
G protein-coupled receptors (GPCRs) constitute the largest family of cell surface receptors. They can exist and act as dimers, but the requirement of dimers for agonist-induced signal initiation and structural dynamics remains largely unknown. Frizzled 6 (FZD6) is a member of Class F GPCRs, which bind WNT proteins to initiate signaling. Here, we show that FZD6 dimerizes and that the dimer interface of FZD6 is formed by the transmembrane α-helices four and five. Most importantly, we present the agonist-induced dissociation/re-association of a GPCR dimer through the use of live cell imaging techniques...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28790174/multiple-dna-binding-modes-for-the-ets-family-transcription-factor-pu-1
#10
Shingo Esaki, Marina G Evich, Noa Erlitzki, Markus W Germann, Gregory M K Poon
The eponymous DNA-binding domain of ETS (E26 transformation specific) transcription factors binds a single sequence-specific site as a monomer over a single helical turn. Following our previous observation by titration calorimetry that the ETS member PU.1 dimerizes sequentially at a single sequence-specific DNA binding site to form a 2:1 complex, we have carried out an extensive spectroscopic and biochemical characterization of site-specific PU.1 ETS complexes. While 10 bp of DNA was sufficient to support PU...
August 8, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28783360/accurate-valence-ionization-energies-from-kohn-sham-eigenvalues-with-the-help-of-potential-adjustors
#11
Adrian Thierbach, Christian Neiss, Lukas Gallandi, Noa Marom, Thomas Körzdörfer, Andreas Goerling
An accurate yet computationally very efficient and formally well justified approach to calculate molecular ionization potentials is presented and tested. The first as well as higher ionization potentials are obtained as the negatives of the Kohn-Sham eigenvalues of the neutral molecule after adjusting the eigenvalues by a recently [Phys. Rev. B {\bf 91}, 245120 (2015)] introduced potential adjustor for exchange-correlation potentials. Technically the method is very simple. Besides a Kohn-Sham calculation of the neutral molecule, only a second Kohn-Sham calculation of the cation is required...
August 7, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28780048/parallel-embryonic-transcriptional-programs-evolve-under-distinct-constraints-and-may-enable-morphological-conservation-amidst-adaptation
#12
Assaf Malik, Tsvia Gildor, Noa Sher, Majed Layous, Smadar Ben-Tabou de-Leon
Embryonic development evolves by balancing stringent morphological constraints with genetic and environmental variation. The design principle that allows developmental transcriptional programs to conserve embryonic morphology while adapting to environmental changes is still not fully understood. To address this fundamental challenge, we compare developmental transcriptomes of two sea urchin species, Paracentrotus lividus and Strongylocentrotus purpuratus, that shared a common ancestor about 40 million years ago and are geographically distant yet show similar morphology...
August 2, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28756053/-patients-with-ulcerative-colitis-and-primary-sclerosing-cholangitis-frequently-have-subclinical-inflammation-in-the-proximal-colon
#13
Noa Krugliak Cleveland, David T Rubin, John Hart, Christopher R Weber, Katherine Meckel, Anthony L Tran, Arthur S Aelvoet, Isabella Pan, Alex Gonsalves, John Nick Gaetano, Kelli Williams, Kristen Wroblewski, Bana Jabri, Joel Pekow
BACKGROUND AND AIMS: Primary sclerosing cholangitis (PSC) patients with ulcerative colitis (UC) have a high risk of colonic neoplasia. As histologic inflammation is an independent risk factor for the development of neoplasia, we hypothesized that patients with UC and PSC have more subclinical disease activity than patients with UC alone. METHODS: We performed a retrospective evaluation of patients with ulcerative pancolitis who were in clinical remission and compared endoscopic and histologic activity between those with and without PSC...
July 26, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28755334/optimized-direct-organogenesis-from-shoot-tip-explants-of-date-palm
#14
Rehab Sidky
In vitro propagation is an available alternative to produce uniform and good-quality planting material to establish large-scale date palm cultivation in a short time. This study was carried out to achieve organogenesis and multiplication directly from shoot tips without callus formation, thus avoiding any possibility of undesirable genetic variability among the regenerated plants. The shoot tips explants are cultured on Murashige and Skoog (MS) medium supplemented with 1 mg/L naphthaleneacetic acid (NAA), 1 mg/L naphthoxyacetic acid (NOA), 2...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28753799/a-novel-urine-based-assay-for-bladder-cancer-diagnosis-multi-institutional-validation-study
#15
Noa Davis, Alexander Shtabsky, Sylvia Lew, Ronny Rona, Ilan Leibovitch, Ofer Nativ, Michael Cohen, Yoram Mor, Uri Lindner, Yael Glickman, Haim Matzkin, Alexander Tsivian, Ofer Gofrit, Ofer Yossepovitch
BACKGROUND: CellDetect is a unique histochemical stain enabling color and morphological discrimination between malignant and benign cells based on differences in metabolic signature. OBJECTIVE: The objective of the present study was to validate the performance of this assay in a controlled, blinded, multicenter study. DESIGN, SETTING, AND PARTICIPANTS: The study, conducted in nine hospitals, included patients with documented history of bladder cancer, monitored for urothelial carcinoma (UCC) or scheduled for bladder cancer surgery...
October 31, 2016: European Urology Focus
https://www.readbyqxmd.com/read/28753273/on-chip-photothermal-analyte-detection-using-integrated-luminescent-temperature-sensors
#16
Simon Anton Pfeiffer, Stefan Nagl
Optical absorbance detection based on attenuated light transmission is limited in sensitivity due to short path lengths in microfluidic and other miniaturized platforms. An alternative is detection using the photothermal effect. Herein we introduce a new kind of photothermal absorbance measurement using integrated luminescent temperature sensor spots inside microfluidic channels. The temperature sensors were photopolymerized inside the channels from NOA 81 UV-curable thiolene prepolymer doped with tris(1,10-phenanthroline)ruthenium(II) temperature probe...
July 28, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28749336/ongoing-hepatitis-a-among-men-who-have-sex-with-men-msm-linked-to-outbreaks-in-europe-in-tel-aviv-area-israel-december-2016-june-2017
#17
Yael Gozlan, Itay Bar-Or, Aviya Rakovsky, Michal Savion, Ziva Amitai, Rivka Sheffer, Noa Ceder, Emilia Anis, Itamar Grotto, Ella Mendelson, Orna Mor
Between December 2016 and June 2017, 19 Hepatitis A virus (HAV)-positive cases, 17 of which were among men who have sex with men (MSM) were identified in the Tel Aviv area. Seven of the 15 sewage samples collected between January and June 2017 were also HAV-positive. All sequences clustered with two of the three strains identified in the current European HAV outbreak. We demonstrate that despite an efficient vaccination programme, HAV can still be transmitted to an unvaccinated high-risk population.
July 20, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28746190/vasa-mrna-ddx4-detection-is-more-specific-than-immunohistochemistry-using-poly-or-monoclonal-antibodies-for-germ-cells-in-the-male-urogenital-tract
#18
Willem P A Boellaard, Hans Stoop, Ad J M Gillis, J Wolter Oosterhuis, Leendert H J Looijenga
VASA, also known as DDX4, is reported to be specifically expressed in cells belonging to the germ cell lineage, both in males and females. Therefore, it could be an informative protein biomarker to be applied on semen to differentiate between obstructive and nonobstructive azoospermia (OA and NOA, respectively). In addition, it could be of value to predict sperm retrieval based on testicular sperm extraction. Immunocytochemistry of proven OA semen using both polyclonal and monoclonal antibodies against VASA showed positive staining of both cells and cell sized particles...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28738600/quantification-of-intercellular-adhesion-forces-measured-by-fluid-force-microscopy
#19
Noa Cohen, Saheli Sarkar, Evangelia Hondroulis, Pooja Sabhachandani, Tania Konry
The mechanics of cancer cell adhesion to its neighboring cells, homotypic or heterotypic, have significant impact on tumor progression and metastasis. Intercellular adhesion has been quantified previously using atomic force microscopy-based methods. Here we show the feasibility of the recently developed fluidic force microscopy (FluidFM) to measure adhesive forces exerted by breast cancer cells. Multiple cell pairs were assessed at precisely controlled, increasing contact durations by pressure-dependent immobilization of a cell at the probe tip...
November 1, 2017: Talanta
https://www.readbyqxmd.com/read/28735335/evaluating-the-effectiveness-of-a-health-promotion-intervention-program-among-physiotherapy-undergraduate-students
#20
Liat Korn, Noa Ben-Ami, Michal Azmon, Ofira Einstein, Meir Lotan
No abstract text is available yet for this article.
July 19, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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