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https://www.readbyqxmd.com/read/28627431/evaluation-of-the-quantamatrix-multiplexed-assay-platform-system-for-simultaneous-detection-of-mycobacteirum-tuberculosis-and-rifampicin-resistance-gene-using-culture-positive-mycobacteria
#1
Hye-Young Wang, Young Uh, Seoyong Kim, Tae-Sun Shim, Hyeyoung Lee
BACKGROUND: The differentiation of Mycobacterium tuberculosis complex (MTBC) from nontuberculous mycobacteria (NTM) is of primary importance for infection control and choice of anti-tuberculosis drugs. Prevailing data on rifampicin (RIF)-resistant TB is essential for early management of multidrug resistant-TB. The aim of this study was to evaluate the usefulness of a newly developed multiplexed, bead-based bioassay (Quantamatrix Multiplexed Assay Platform; QMAP) for the rapid differentiation of 23 Mycobacterium species including MTBC and RIF-resistant strains...
June 13, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28624788/systematic-review-and-meta-analysis-of-the-efficacy-of-breast-conservation-therapy-followed-by-radiotherapy-in-four-breast-cancer-subtypes
#2
Xin-Bin Pan, Rou-Jun Chen, Shi-Ting Huang, Yan-Ming Jiang, Xiao-Dong Zhu
The different molecular subtypes of breast cancer are associated with distinct outcomes. We assessed the efficacy of breast conservation therapy (BCT) followed by radiotherapy for patients with different breast cancer subtypes. We searched the MEDLINE, EMBASE, and Cochrane Library databases to identify studies published prior to April 30, 2016 that assessed the efficacy of BCT followed by radiotherapy in breast cancer patients with different molecular subtypes. A meta-analysis of seven studies that included 3,798 luminal A, 770 luminal B, 344 human epidermal growth factor receptor 2 (Her-2), and 767 triple-negative breast cancer (TNBC) patients was performed...
May 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/28624012/differentiation-of-small-intrahepatic-mass-forming-cholangiocarcinoma-from-small-liver-abscess-by-dual-source-dual-energy-ct-quantitative-parameters
#3
Ji Eun Kim, Hyun Ok Kim, Kyungsoo Bae, Jae Min Cho, Ho Cheol Choi, Dae Seob Choi
PURPOSE: To investigate the use of dual source dual-energy CT (DECT) quantitative parameters compared with the use of conventional CT for differentiating small (≤3cm) intrahepatic mass-forming cholangiocarcinoma (IMCC) from small liver abscess (LA) during the portal venous phase (PVP). MATERIAL AND METHODS: In this institutional review board-approved, retrospective study, 64 patients with IMCCs and 52 patients with LAs who were imaged in PVP using dual-energy mode were included retrospectively...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28617680/pulse-photoplethysmographic-amplitude-and-heart-rate-variability-during-laparoscopic-cholecystectomy-a-prospective-observational-study
#4
Riccardo Colombo, Ferdinando Raimondi, Alberto Corona, Andrea Marchi, Beatrice Borghi, Simone Pellegrin, Paola Bergomi, Tommaso Fossali, Stefano Guzzetti, Alberto Porta
BACKGROUND: Surgical stress affects the autonomic nervous system by increasing sympathetic outflow. One method of monitoring sympathetic activity is pulse photoplethysmographic analysis. From this two indices can be derived - autonomic nervous system state (ANSS) and ANSS index (ANSSi). It has recently been claimed that these indices can be used to measure sympathetic activity in anaesthetised patients, but their validity has not yet been demonstrated. OBJECTIVE: To measure changes in pulse photoplethysmographic indices and determine any agreement with autonomic nervous system modulation of the cardiovascular system in healthy study participants during surgery under general anaesthesia...
June 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28614864/-the-patient-with-chest-trauma-surgical-management
#5
Patrick Zardo, Henning Busk, Stefan Piatek, Norman Zinne, Irina Kropivnitskaya, Ingo Kutschka
Even though isolated cases of penetrating chest wounds are exceptionally rare in Germany, chest trauma accounts for major morbidity and mortality in over 18 0000 multitrauma patients encountered every year. Injuries range from immediately fatal cardiac wounds and major vessel lacerations to intercostal bleeding, parenchymal damage, chronic haematothorax and secondary empyema. Placement of large-bore chest tubes constitutes a sufficient treatment for most of these pathologies. In select cases further treatment either by minimally invasive techniques (VATS) or conventional thoracotomy is warranted...
June 2017: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/28592201/comparative-efficacy-and-safety-of-intravenous-or-subcutaneous-belimumab-in-combination-with-standard-therapy-in-patients-with-active-systemic-lupus-erythematosus-a-bayesian-network-meta-analysis-of-randomized-controlled-trials
#6
Y H Lee, G G Song
Objective In this study, we aimed to assess the relative efficacy and safety of intravenous (IV) or subcutaneous (SC) belimumab compared with those of placebo in patients with active systemic lupus erythematosus (SLE). Methods We performed a Bayesian network meta-analysis to combine the direct and indirect evidence from randomized controlled trials (RCTs) examining the efficacy and safety of belimumab 1 mg/kg and 10 mg/kg IV administration, and belimumab 200 mg SC injection, and placebo in patients with active SLE despite having received standard therapy...
January 1, 2017: Lupus
https://www.readbyqxmd.com/read/28554891/dna-repair-gene-expressions-are-related-to-bone-marrow-cellularity-in-myelodysplastic-syndrome
#7
Howard L Ribeiro, Allan Rodrigo S Maia, Roberta Taiane G de Oliveira, Marília Braga Costa, Izabelle Rocha Farias, Daniela de Paula Borges, Juliana Cordeiro de Sousa, Silvia Maria M Magalhães, Ronald F Pinheiro
OBJECTIVE: To evaluate the expression of genes related to nuclear excision (ERCC8, XPA and XPC), homologous recombination and non-homologous end-joining (ATM, BRCA1, BRCA2 and LIG4) repair mechanisms, using quantitative PCR methodologies, and it relation with bone marrow cellularity in myelodysplastic syndrome (MDS). METHODS AND RESULTS: A total of 51 adult de novo patients with MDS (3 refractory anaemia (RA), 11 refractory anaemia with ringed sideroblasts (RARS), 28 refractory cytopenia with multilineage dysplasia (RCMD), 3 refractory anaemia with excess blasts type I (RAEB-I), 5 refractory anaemia with excess blasts type II (RAEB-II), and 1 chronic myelomonocytic leukaemia (CMML) were evaluated...
May 29, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28545729/development-of-fast-efficient-and-ecological-method-employing-vortex-assisted-dispersive-liquid-liquid-microextraction-combined-with-fast-gas-chromatography-mass-spectrometry-for-pesticide-residues-analysis-in-alcohol-content-samples
#8
Svetlana Hrouzková, Mária Brišová, Agneša Szarka
A fast, ecological, and efficient method employing vortex-assisted dispersive liquid-liquid microextraction (DLLME) method for isolation and preconcentration of selected endocrine disrupting pesticides from beverages containing some degree of alcohol was developed. The effect of several extraction parameters, such as selection of extractive solvent, its volume and extraction time, the salt addition was investigated. Four different extractive solvents (chloroform, tetrachloroethane, tetrachloromethane and toluene) and their combinations were evaluated for DLLME...
May 17, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28528228/determination-of-soluble-sugar-profile-in-rice
#9
Xianqiao Hu, Changyun Fang, Lin Lu, Zhanqiang Hu, Yafang Shao, Zhiwei Zhu
Soluble sugars in rice are the main components affecting sweetness taste of rice. In this paper, an accurate, precise and rapid method for simultaneous determination of multi soluble sugars in rice by using ion chromatography equipped with pulsed amperometric detector was presented. Pretreatment and parameters of ion chromatography and pulsed amperometric detector were optimized. Regression coefficients (R) of 0.9998, 1.0000, 0.9979, 0.9998 and 0.9998 were obtained for glucose, fructose, sucrose, raffinose and maltose, respectively...
May 5, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28522913/gutuo-jiejiu-decoction-improves-survival-of-patients-with-severe-alcoholic-hepatitis-a-retrospective-cohort-study
#10
Hong-Yuan Mou, Hong-Ming Nie, Xiao-Yu Hu
AIM: To verify the value of Gutuo Jiejiu decoction in improving the survival of patients with severe alcoholic hepatitis (SAH). METHODS: We performed a retrospective cohort study in consecutive patients diagnosed with SAH at the Teaching Hospital of Chengdu University of Traditional Chinese Medicine and Shuguang Hospital, Shanghai University of Traditional Chinese Medicine. The traditional Chinese medicine formula Gutuo Jiejiu decoction was employed as an exposure factor...
April 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28498818/comparison-of-the-efficacy-between-intensity-modulated-radiotherapy-and-two-dimensional-conventional-radiotherapy-in-stage-ii-nasopharyngeal-carcinoma
#11
Xin-Bin Pan, Kai-Hua Chen, Shi-Ting Huang, Yan-Ming Jiang, Jia-Lin Ma, Zhong-Guo Liang, Song Qu, Ling Li, Long Chen, Xiao-Dong Zhu
We compared treatment outcomes in patients with stage II nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy (IMRT) or two-dimensional conventional radiotherapy (2D-CRT). Stage II (2010 UICC/AJCC staging system) NPC patients treated with IMRT (n = 178) or 2D-CRT (n = 73) between January 2007 and December 2014 were retrospectively analyzed. Patients were matched using the propensity score-matching method. The primary endpoint was overall survival (OS). Secondary endpoints were local relapse-free survival (LRFS), regional relapse-free survival (RRFS), distant metastasis-free survival (DMFS), and disease-free survival (DFS)...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28498145/brief-report-progression-of-atherosclerosis-in-hiv-infected-individuals-prospective-data-from-an-asian-cohort
#12
Grace Lui, Ronald C W Ma, Ping Chook, Chun-Kwok Wong, Claudia H T Tam, Michael H M Chan, Shui-Shan Lee, Rity Y K Wong, Catherine S K Cheung, Kin-Wing Choi, Ping-Chung Leung, Ka-Hing Wong, Kenny C W Chan, Nelson Lee
BACKGROUND: The magnitude and risk factors of progression of atherosclerosis in Asian HIV-infected individuals were unknown. This study aimed to evaluate: (1) the rate of progression of atherosclerosis in HIV-infected individuals, and (2) metabolic and inflammatory parameters that may predict atherosclerosis progression in HIV-infected individuals in an Asian cohort. SETTING: A prospective, longitudinal study was performed among adults attending an HIV Metabolic clinic in Hong Kong...
June 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28492927/prevalence-of-auditory-problems-in-children-with-feeding-and-swallowing-disorders
#13
Vishakha Waman Rawool
Purpose: Although an interdisciplinary approach is recommended for assessment and management of feeding or swallowing difficulties, audiologists are not always included in the interdisciplinary team. The purpose of this study is to report the prevalence of middle ear and hearing problems in children with feeding and swallowing disorders and to compare this prevalence with that in typical children. Method: A total of 103 children were included in the study: 44 children with feeding and swallowing disorders and 59 children without any such disorders...
May 24, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/28490932/contextualizing-the-use-of-oncologic-imaging-within-treatment-phases-imaging-trends-and-modality-preferences-2000-2014
#14
T P Copeland, J M Creasman, D J Seidenwurm, B L Franc
BACKGROUND: In the present study, we retrospectively evaluated the use of tomographic imaging in adult cancer patients to clarify how recent growth plateaus in the use of tomographic imaging in the United States might have affected oncologic imaging during the same period. METHODS: At a U.S. academic cancer centre, 12,059 patients with dates of death from January 2000 through December 2014 were identified. Imaging was restricted to brain and body computed tomography (ct), brain and body magnetic resonance (mr), and body positron-emission tomography (pet) with and without superimposed ct...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28469818/prevalence-and-distribution-of-odontogenic-cysts-in-a-mexican-sample-a-753-cases-study
#15
Luis Villasis-Sarmiento, Javier Portilla-Robertson, Arcelia Melendez-Ocampo, Luis-Alberto Gaitan-Cepeda, Elba-Rosa Leyva-Huerta
BACKGROUND: Odontogenic cysts (OC) are the most frequent lesions of the jaws and their constant epidemiological update is necessary and indispensable. Therefore the principal objective of this report was To determine prevalence and clinical-demographical characteristics of OC in a Mexican sample. MATERIAL AND METHODS: 753 cases of OC coming from the archive of a head and neck histopathological teaching service, from January 2000 to December 2013, were included. OC cases were re-assessed according 2005 WHO classification...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28462684/integrated-gasification-combined-cycle-using-egyptian-maghara-coal-rice-straw-feedstock
#16
A Hegazy, A O Ghallab, F H Ashour
Rice straw is an agricultural waste that causes an annoying problem in Egypt if it is not well exploited. This study focuses on using this waste in power generation by co-gasification of Egyptian Maghara coal and rice straw blends using entrained flow gasifier technology. Aspen Plus was used to conduct a parametric study for investigation of the effect of changing the inputs to the gasifier on the produced gas composition. Three different input parameters, influencing the performance of the gasifier, including the percentage of coal to rice straw in the blend, the fraction of added water to the blend, and the mass percentage of oxygen with respect to the mass of the blend fed to the gasifier were analysed...
April 1, 2017: Waste Management & Research
https://www.readbyqxmd.com/read/28451435/circumcision-in-hemophilia-using-low-quantity-of-factor-concentrates-experience-from-dakar-senegal
#17
Moussa Seck, Aloïse Sagna, Mame Sokhna Guéye, Blaise Félix Faye, Diariétou Sy, Sokhna Aissatou Touré, Abibatou Sall, Awa Oumar Touré, Saliou Diop
BACKGROUND: Circumcision in hemophiliacs is a delicate surgery because of bleeding risks that could be avoided by adequate substitution of coagulation factor. This practice is very challenging in countries where anti hemophilic treatment is inaccessible. The study aimed to evaluate a circumcision protocol in hemophilia A using low quantities of factor concentrates. METHODS: This prospective study included 26 hemophiliacs A who underwent circumcision in 2014. Medical treatment protocol using low quantity of factor concentrates was drafted by physicians of the Hemophilia Treatment Center and the surgical protocol by experienced surgeons...
2017: BMC Hematology
https://www.readbyqxmd.com/read/28434773/mstroke-mobile-stroke-improving-acute-stroke-care-with-smartphone-technology
#18
Benjamin Y Andrew, Colleen M Stack, Julian P Yang, Jodi A Dodds
OBJECTIVE: This study aimed to evaluate the effect of method and time of system activation on clinical metrics in cases utilizing the Stop Stroke (Pulsara, Inc.) mobile acute stroke care coordination application. METHODS: A retrospective cohort analysis of stroke codes at 12 medical centers using Stop Stroke from March 2013 to May 2016 was performed. Comparison of metrics (door-to-needle time [DTN] and door-to-CT time [DTC], and rate of DTN ≤ 60 minutes [goal DTN]) was performed between subgroups based on method (emergency medical service [EMS] versus emergency department [ED]) and time of activation...
April 20, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28421169/high-prevalence-of-virulence-genes-in-specific-genotypes-of-atypical-enteropathogenic-escherichia-coli
#19
Yanmei Xu, Xiangning Bai, Yujuan Jin, Bin Hu, Hong Wang, Hui Sun, Ruyue Fan, Shanshan Fu, Yanwen Xiong
Atypical enteropathogenic Escherichia coli (aEPEC) strains are emerging enteropathogens that have been detected worldwide. A collection of 228 aEPEC strains (121 from diarrheal patients, 27 from healthy carriers, 47 from animals and 33 from raw meats) were investigated for serotypes, virulence gene profiles and phylogenetic relationships. Sixty-six O serogroups were identified. Serogroup O51 was the most prevalent, followed by O119, O26 and O76. For the 20 virulence genes detected, statistically significant differences were observed in the overall prevalence of efa1 (lifA), nleB, nleE, set/ent, paa, and ehxA genes among strains from diarrheal patients, healthy carriers, animals and raw meats, respectively...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28400861/revision-of-echocardiographic-indications-and-findings-in-neurologically-ill-patients
#20
Claudia Stöllberger, Christian Wegner, Josef Finsterer
BACKGROUND AND OBJECTIVE: Little is known about the general indications for echocardiography and the prevalence of abnormalities detected by echocardiography in patients who are referred from a neurological department. Left ventricular hypertrabeculation/noncompaction (LVHT) is associated with neuromuscular disorders and embolism. The aim of the study was to assess the indications for echocardiography in patients from a neurological department and to review the cine-loops of the examinations in order to assess the frequency of abnormal echocardiographic findings with special regard to LVHT...
2017: Open Cardiovascular Medicine Journal
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