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https://www.readbyqxmd.com/read/28101700/predicting-brain-metastases-for-non-small-cell-lung-cancer-based-on-magnetic-resonance-imaging
#1
Gang Yin, Churong Li, Heng Chen, Yangkun Luo, Lucia Clara Orlandini, Pei Wang, Jinyi Lang
In this study the relationship between brain structure and brain metastases (BM) occurrence was analyzed. A model for predicting the time of BM onset in patients with non-small cell lung cancer (NSCLC) was proposed. Twenty patients were used to develop the model, whereas the remaining 69 were used for independent validation and verification of the model. Magnetic resonance images were segmented into cerebrospinal fluid, gray matter (GM), and white matter using voxel-based morphometry. Automatic anatomic labeling template was used to extract 116 brain regions from the GM volume...
January 18, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28039296/effectiveness-of-senior-dance-on-risk-factors-for-falls-in-older-adults-danse-a-study-protocol-for-a-randomised-controlled-trial
#2
Marcia R Franco, Catherine Sherrington, Anne Tiedemann, Leani S Pereira, Monica R Perracini, Claudia R S Faria, Rafael Z Pinto, Carlos M Pastre
INTRODUCTION: Strong evidence shows that exercise is effective to improve fall risk factors among older people. However, older people's participation and adherence to exercise programmes is suboptimal. Type of exercise and apathy are reported to be barriers to exercise participation, suggesting that new effective interventions are needed. The primary aim of this randomised controlled trial is to investigate the effect of Senior Dance plus brief education for falls prevention on balance among people aged 60 years or over, compared with a control group receiving only brief education...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28024428/population-structure-and-genetic-diversity-of-indian-major-carp-labeo-rohita-hamilton-1822-from-three-phylo-geographically-isolated-riverine-ecosystems-of-india-as-revealed-by-mtdna-cytochrome-b-region-sequences
#3
Bijay Kumar Behera, Vishwamitra Singh Baisvar, Swaraj Priyaranjan Kunal, Dharmendra Kumar Meena, Debarata Panda, Sudip Pakrashi, Prasenjit Paria, Pronob Das, Dibakar Bhakta, Dipesh Debnath, Suvra Roy, V R Suresh, J K Jena
The population structure and genetic diversity of Rohu (Labeo rohita Hamilton, 1822) was studied by analysis of the partial sequences of mitochondrial DNA cytochrome b region. We examined 133 samples collected from six locations in three geographically isolated rivers of India. Analysis of 11 haplotypes showed low haplotype diversity (0.00150), nucleotide diversity (π) (0.02884) and low heterogeneity value (0.00374). Analysis of molecular variance (AMOVA) revealed the genetic diversity of L. rohita within population is very high than between the populations...
December 26, 2016: Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis
https://www.readbyqxmd.com/read/28009315/differences-in-ecg-characteristics-and-co-morbidities-among-patients-who-underwent-elective-surgical-repair
#4
I Botchorishvili, N Sharashidze, N Pargalava, Z Pagava, G Saatashvili
The aim of the study was to assess differences in ECG features and prevalence of comorbidies between two groups of patiens: with Abdominal Aortic Aneurism (AAA) and Aorto-Iliac Occlusive Desieses-Lerish Syndrome (LS). Data was collected for all consecutive adult patients who underwent elective surgical repair of AAA (fusiform aneurysm) or LS at "The Center of Vascular and Heart Diseases" (Tbilisi, Georgia) between 2010 and 2014. We studied a prevalence of Arterial Hypertension (AHT); Diabetes mellitus (DM); Renal Failure (RF),Peripheral Artery Disease (PAD), Coronary Artery Disease (CAD) and rate of coronary revascularization in these patients; We also, investigate some of the electrocariographic characteristics: Corrected QT interval(QTC),QT dispersion(QTD)...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27995667/liver-dysfunction-in-women-with-pregnancy-induced-antithrombin-deficiency
#5
Mamoru Morikawa, Kosuke Kawabata, Emi Kato-Hirayama, Yasunari Oda, Hiroto Ueda, Soromon Kataoka, Takashi Yamada, Kazuhiko Okuyama, Kazuo Sengoku, Hisanori Minakami
AIM: The aim of this study was to determine whether women with pregnancy-induced antithrombin deficiency (PIATD) had higher risk of liver dysfunction in the absence of thrombocytopenia. METHODS: We carried out a retrospective observational study at five centers in all 129 women with incidentally found PIATD among 5249 maternities and 129 control women without PIATD matched for number of fetuses and gestational week at delivery. PIATD was diagnosed in women with antenatal antithrombin (AT) activities of ≤75% followed by a further decrease to ≤65% peripartum...
December 19, 2016: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/27992935/qsar-differential-model-for-prediction-of-sirt1-modulation-using-monte-carlo-method
#6
A Kumar, S Chauhan
Silent information regulator 2 homologue one (SIRT1) modulators have therapeutic potential for a number of diseases like cardiovascular, metabolic, inflammatory and age related disorders. Here, we have studied both activators and inhibitors of SIRT1 and constructed differential quantitative structure activity relationship (QSAR) models using CORAL software by Monte Carlo optimization method and SMILES notation. 3 splits divided into 3 subsets: sub-training, calibration and test sets, were examined and validated with a prediction set...
December 19, 2016: Drug Research
https://www.readbyqxmd.com/read/27978834/comparison-of-the-placebo-effect-between-different-non-penetrating-acupuncture-devices-and-real-acupuncture-in-healthy-subjects-a-randomized-clinical-trial
#7
RANDOMIZED CONTROLLED TRIAL
Leonardo Yung Dos Santos Maciel, Paula Michele Dos Santos Leite, Mauricio Lima Poderoso Neto, Andreza Carvalho Rabelo Mendonça, Carla Carolina Alves de Araujo, Jersica da Hora Santos Souza, Josimari Melo DeSantana
BACKGROUND: Several studies have used placebo acupuncture methods in recent years as a way for blinding therapeutic effect of acupuncture, however placebo method selection has not followed enough methodological criteria to the point of stabilishing a consensus of what should be the best method to be used. This study aimed to evaluate the effectiveness of three different placebo acupuncture methods for blinding applied in healthy subjects. METHODS: This study was approved by the Ethics Committee of the Federal University of Sergipe with the number 47193015...
December 15, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27923799/steinmaus-and-smith-respond-to-proximity-to-gasoline-stations-and-childhood-leukemia
#8
Craig Steinmaus, Martyn T Smith
Benzene is an established cause of adult leukemia, but its role in childhood leukemia is less clear. In a recent meta-analysis, we identified associations of childhood leukemia with occupational and household product benzene exposure and traffic-related pollution. Residential proximity to gasoline stations or automobile repair facilities may be another source of benzene, and in 3 studies assessing these sources, we identified a summary relative risk of 1.59 (95% confidence interval: 0.70, 3.62). Although not statistically significant, this summary relative risk was of a magnitude similar to that of our other positive findings...
December 6, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27909490/effects-of-atrial-fibrillation-cardioversion-after-percutaneous-mitral-balloon-valvuloplasty-on-echocardiographic-left-and-right-atrial-functions
#9
Ayman Morttada Md, Aly Ramzy Md, Said Khaled Md, Amal Ayoub Md, Sameh Samir Md, Hossam Zaki Md
Amongst patients with mitral stenosis (MS), the most common complication is AF.Our study aimed at evaluating the effect of AF cardioversion after Percutaneous Mitral Balloon Valvuloplasty (PMBV) on echocardiographic atrial functions. The study included 34 patients with MS and AF, presenting to Ain-shams University hospitals, who underwent successful PMBV then randomized into 2 different groups according to AF management strategy. Group-I patients (n=16) received DC cardioversion after amiodarone infusion (within 24 hours post-PMBV) in addition to anticoagulation...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27859956/noninvasive-hepatic-fibrosis-staging-using-mr-elastography-the-usefulness-of-the-bayesian-prediction-method
#10
Shintaro Ichikawa, Utaroh Motosugi, Nobuyuki Enomoto, Masanori Matsuda, Hiroshi Onishi
PURPOSE: To evaluate the usefulness of the Bayesian method for hepatic fibrosis staging with magnetic resonance elastography (MRE). MATERIALS AND METHODS: The sample of this retrospective study comprised patients with chronic liver disease (n = 309), in whom histopathological fibrosis staging and MRE using either a 1.5T (n = 214) or a 3T magnetic resonance imaging (MRI) system (n = 95) had been performed. The optimal cutoff stiffness value was determined and used to calculate the discrimination ability of fibrosis staging by the cutoff method...
November 9, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27853498/dosimetry-of-three-cone-beam-computerized-tomography-scanners-at-different-fields-of-view-in-terms-of-various-head-and-neck-organs
#11
Sima Nikneshan, Mahmood Reza Aghamiri, Ehsan Moudi, Nika Bahemmat, Hoora Hadian
BACKGROUND: Marketing new radiography devices necessitates documenting their absorbed X-ray doses. Since the current literature lacks studies on new devices, we assessed the doses of two new devices that had not previously been assessed. OBJECTIVES: The new devices were compared to the Promax three dimensional (3D) scanner at two fields of view (FOV) in nine critical head and neck tissues and organs. MATERIALS AND METHODS: Seventeen thermoluminescence dosimeters positioned in an average-sized male RANDO phantom were used to determine the dosimetry of the three cone beam computerized tomography devices (NewTom VGi, NewTom 5G, and Promax 3D) at two field of views (FOVs), one small and one large...
July 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27843725/development-of-highly-transferable-microsatellites-for-panax-ginseng-araliaceae-using-whole-genome-data
#12
Peng Jiang, Feng-Xue Shi, Ya-Ling Li, Bao Liu, Lin-Feng Li
PREMISE OF THE STUDY: Highly transferable expressed sequence tag (EST) microsatellites were developed for Panax ginseng (Araliaceae), one of the most celebrated traditional Chinese medicines and an endangered species in East Asia, using whole-genome data. METHODS AND RESULTS: Twenty-one EST microsatellites were characterized from next-generation sequencing and were composed of di- and trinucleotide repeats. Polymorphisms and genetic diversity were evaluated for 45 accessions of three ginseng landraces...
November 2016: Applications in Plant Sciences
https://www.readbyqxmd.com/read/27835932/treatment-of-frictional-dental-hypersensitivity-fdh-with-computer-guided-occlusal-adjustments
#13
Nick Yiannios, Robert B Kerstein, John Radke
OBJECTIVE: To verify the efficacy of treating dentin/dental hypersensitivity (DH) to Cold Ice Water Swish testing before and after subjects undergo the Immediate Complete Anterior Guidance Development (ICAGD) computer-guided occlusal adjustment. METHODS: One hundred chronically dysfunctional patients with known cold sensitivity swished ice water intraorally to elicit a DH response scored on a Visual Analog Scale (VAS). The subjects then underwent the ICAGD coronoplasty, which was followed by a second ice water swish scored with a second VAS...
November 11, 2016: Cranio: the Journal of Craniomandibular Practice
https://www.readbyqxmd.com/read/27834785/physiological-effects-of-a%C3%A2-single-chest-physiotherapy-session-in-mechanically-ventilated-and-extubated-preterm-neonates
#14
Y Mehta, J Shetye, R Nanavati, A Mehta
OBJECTIVE: To assess the changes on various physiological cardio-respiratory parameters with a single chest physiotherapy session in mechanically ventilated and extubated preterm neonates with respiratory distress syndrome. STUDY DESIGN: This is a prospective observational study in a neonatal intensive care unit setting. Sixty preterm neonates with respiratory distress syndrome, thirty mechanically ventilated and thirty extubated preterm neonates requiring chest physiotherapy were enrolled in the study...
2016: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/27832740/inter-and-intra-reproducibility-of-genotypes-from-sheep-technical-replicates-on-illumina-and-affymetrix-platforms
#15
Donagh P Berry, Aine O'Brien, Eamonn Wall, Kevin McDermott, Shane Randles, Paul Flynn, Stephen Park, Jenny Grose, Rebecca Weld, Noirin McHugh
BACKGROUND: Accurate genomic analyses are predicated upon access to accurate genotype input data. The objective of this study was to quantify the reproducibility of genotype data that are generated from the same genotype platform and from different genotyping platforms. METHODS: Genotypes based on 51,121 single nucleotide polymorphisms (SNPs) for 84 animals that were each genotyped on Illumina and Affymetrix platforms and for another 25 animals that were each genotyped twice on the same Illumina platform were compared...
November 10, 2016: Genetics, Selection, Evolution: GSE
https://www.readbyqxmd.com/read/27808037/patient-are-satisfied-one-year-after-decompression-surgery-for-lumbar-spinal-stenosis
#16
Rune Tendal Paulsen, Jamal Bech Bouknaitir, Søren Fruensgaard, Leah Carreron, Mikkel Andersen
INTRODUCTION: Lumbar spinal stenosis (LSS) is a clinical syndrome of buttock or lower extremity pain, which may occur with or without back pain. The syndrome is associated with diminished space available for the neural and vascular elements in the lumbar spine. LSS is typically seen in elderly patients, its prevalence is estimated to be 47% in people over the age 60 years. LSS is the most common reason for spine surgery in Denmark and the number of surgical procedures is likely to increase due to demographic changes...
November 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27805332/reticulocyte-hemoglobin-vis-a-vis-serum-ferritin-as-a-marker-of-bone-marrow-iron-store-in-iron-deficiency-anemia
#17
Sudhir Mehta, Laxmi Kant Goyal, Debashish Kaushik, Sandhya Gulati, Nidhi Sharma, L Harshvardhan, Naveen Gupta
AIM: To evaluate reticulocyte hemoglobin (RET-He) vis-a-vis serum ferritin as a marker of bone marrow iron store in iron deficiency anemia (IDA). MATERIAL AND METHODS: A hospital based analytic study was conducted among patients (age group 15-65 years) with newly diagnosed and untreated IDA admitted in medicine ward and not suffering from any inflammatory disorders (excluded by C-reactive protein). Patient having other forms of anemia/ hemoglobinopathies/ malignancy, MCV > 80 fL and pregnant female were excluded...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27787387/effects-of-saxagliptin-add-on-therapy-to-insulin-on-blood-glycemic-fluctuations-in-patients-with-type-2-diabetes-a-randomized-control-open-labeled-trial
#18
Feng-Fei Li, Lan-Lan Jiang, Reng-Na Yan, Hong-Hong Zhu, Pei-Hua Zhou, Dan-Feng Zhang, Xiao-Fei Su, Jin-Dan Wu, Lei Ye, Jian-Hua Ma
BACKGROUND: To investigate whether saxagliptin add-on therapy to continuous subcutaneous insulin infusion (CSII) further improve blood glycemic control than CSII therapy in patients with newly diagnosed type 2 diabetes (T2D). METHODS: This was a single-center, randomized, control, open-labeled trial. Newly diagnosed T2D patients were recruited between February 2014 and December 2015. Subjects were divided into saxagliptin add-on therapy to CSII group (n = 31) and CSII therapy group (n = 38)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27783980/application-of-an-ultrahigh-performance-liquid-chromatography-coupled-to-quadrupole-orbitrap-high-resolution-mass-spectrometry-for-the-rapid-screening-identification-and-quantification-of-illegal-adulterated-glucocorticoids-in-herbal-medicines
#19
Shuiqing Zhou, Changchuan Guo, Feng Shi, Wei Jiang, Lei Wang
In this work, the ultrahigh-performance liquid chromatography quadrupole orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was applied to the rapid screening, identification and quantification of the illegal adulterated glucocorticoids in herbal medicines. The mass spectrometer was operated in positive ion mode and Full MS/dd-MS(2) (data-dependent MS(2)) mode, where selected ions were subjected to a dd-MS(2) scan with given fragmentation energy following a Full MS scan. The application of 70 000 FWHM mass resolution and narrow mass windows (5ppm) effectively improve the selectivity of the method, and a single injection was sufficient to perform the simultaneous screening and identification/quantification of 14 glucocorticoids in 15min...
December 1, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/27781248/-application-of-multidisciplinary-treatment-in-patients-with-liver-metastasis-of-colorectal-cancer
#20
Hao Li, Xiaohui Du, Shaoyou Xia, Songyan Li, Jian Xu, Guijun Zou, Shidong Hu
OBJECTIVE: To evaluate the application of multidisciplinary treatment (MDT) in patients with liver metastasis of colorectal cancer(CLM). METHODS: Clinical data of 118 patients with liver metastasis of colorectal cancer, including 32 patients with MDT (MDT group) and 86 patients without MDT (control group), from February 2014 to April 2015 in PLA General Hospital were analyzed retrospectively. Compliance of preoperative examination and adjuvant therapy, and efficacy-associated indexes were compared between the two groups...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
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