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Shuiqing Zhou, Changchuan Guo, Feng Shi, Wei Jiang, Lei Wang
In this work, the ultrahigh-performance liquid chromatography quadrupole orbitrap high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS) was applied to the rapid screening, identification and quantification of the illegal adulterated glucocorticoids in herbal medicines. The mass spectrometer was operated in positive ion mode and Full MS/dd-MS(2) (data-dependent MS(2)) mode, where selected ions were subjected to a dd-MS(2) scan with given fragmentation energy following a Full MS scan. The application of 70 000 FWHM mass resolution and narrow mass windows (5ppm) effectively improve the selectivity of the method, and a single injection was sufficient to perform the simultaneous screening and identification/quantification of 14 glucocorticoids in 15min...
October 11, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Hao Li, Xiaohui Du, Shaoyou Xia, Songyan Li, Jian Xu, Guijun Zou, Shidong Hu
OBJECTIVE: To evaluate the application of multidisciplinary treatment (MDT) in patients with liver metastasis of colorectal cancer(CLM). METHODS: Clinical data of 118 patients with liver metastasis of colorectal cancer, including 32 patients with MDT (MDT group) and 86 patients without MDT (control group), from February 2014 to April 2015 in PLA General Hospital were analyzed retrospectively. Compliance of preoperative examination and adjuvant therapy, and efficacy-associated indexes were compared between the two groups...
October 25, 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
Timothy S Church
The analysis plan and article in this issue of the Journal by Evenson et al. (Am J Epidemiol 2016;000(000):0000-0000) is well-conceived, thoughtfully conducted, and tightly written. The authors utilized the National Health and Nutrition Examination Survey data set to examine the association between accelerometer-measured physical activity level and mortality and found that meeting the 2013 federal Physical Activity Guidelines resulted in a 35% reduction in risk of mortality. The timing of these findings could not be better, given the ubiquitous nature of personal accelerometer devices...
October 19, 2016: American Journal of Epidemiology
Tatiana Moro, Grant Tinsley, Antonino Bianco, Giuseppe Marcolin, Quirico Francesco Pacelli, Giuseppe Battaglia, Antonio Palma, Paulo Gentil, Marco Neri, Antonio Paoli
BACKGROUND: Intermittent fasting (IF) is an increasingly popular dietary approach used for weight loss and overall health. While there is an increasing body of evidence demonstrating beneficial effects of IF on blood lipids and other health outcomes in the overweight and obese, limited data are available about the effect of IF in athletes. Thus, the present study sought to investigate the effects of a modified IF protocol (i.e. time-restricted feeding) during resistance training in healthy resistance-trained males...
October 13, 2016: Journal of Translational Medicine
A V Sahasrabuddhe, S U Pitale, Dhoble, J Shivalkar, M M Sagdeo
BACKGROUND: To evaluate presence of diastolic dysfunction in obese peripubertal males (8-18 years of age). To correlate diastolic dysfunction with insulin resistance, insulin levels and omental and epicardial fat. METHODS: Obese males (n=46) and age matched healthy lean controls (n=50) in the age group of 8-18 years were included in this study. Anthropometric measurements were recorded. Investigations done: Fasting blood sugar and serum insulin levels, lipid profile, 2-D Echocardiography to assess left ventricular diastolic function and epicardial fat, abdominal CT scan to measure omental fat and ultrasound for NAFLD...
February 2016: Journal of the Association of Physicians of India
Preeti Patil-Chhablani, Krishnapriya Kothamasu, Ramesh Kekunnaya, Virender Sachdeva, Vivek Warkad
PURPOSE: To evaluate the surgical outcome of augmented superior rectus transposition (SRT) and medial rectus recession (MRc) in patients with abducens nerve palsy. METHODS: The medical records of consecutive patients with abducens nerve palsy who underwent unilateral or bilateral simultaneous SRT with MRc from January 2012 to December 2014. Patients with previous strabismus surgery or botulinum toxin injection were excluded. Primary outcome measures were esotropia in primary position and abduction deficit...
October 7, 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Sol Bee Han, Young Cheol Yoon, Jong Won Kwon
BACKGROUND AND PURPOSE: Slice-Encoding Metal Artifact Correction (SEMAC) sequence is one of the metal artifact reduction techniques of anatomical structure, but there has been no report about evaluation of post-operative complications. The purpose of this article is to compare the anatomical visibility between fast spin echo (FSE) and FSE-SEMAC and to evaluate the additional value of FSE-SEMAC in diagnostic confidence of the complications. MATERIALS AND METHODS: We conducted a retrospective study with 54 patients who received lumbar spinal surgery and MR images including FSE-SEMAC...
2016: PloS One
Verónica Jiménez Díaz, Alfonso Carlos Prada Cañizares, Ismael Auñón Martín, Miguel Aroca Peinado, Pedro Caba Doussoux
BACKGROUND: Factors that impede closed reduction in intertrochanteric fractures remain unknown. This study was designed with the aim of establishing radiological variables that can predict an open reduction when nailing those type of fractures. MATERIALS AND METHODS: Observational prospective study carried out between March 2013 and March 2015. Patients of both gender who suffered an intertrochanteric fracture, and who were surgically treated by intramedullary nailing (PFN-A), were included...
September 2016: Injury
Khalil Ghoussoub, Alain El Asmar, Gaby Kreichati, Sawma Wakim, Mayla Bakhache, Maria Baz, Zakhia Naoum
OBJECTIVE: Our study aims to assess the prevalence and risk factors of low back pain occurred in health care workers in a Lebanese Hospital, and the impact of gestural and postural education in prevention. MATERIAL/PATIENTS AND METHODS: A transversal survey with retrospective data collection was conducted at the University Hospital Center Hôtel-Dieu de France (HDF) Beirut in November 2015. It was based on a questionnaire of 29 items exploring the demographic, anthropometric and social data subjects and data for low back pain: duration, trigger back pain, risk factors, low back pain history, and the role of staff training to handling...
September 2016: Annals of Physical and Rehabilitation Medicine
Lei Gao, Yuqian Sun, Fanyi Meng, Mingzhe Han, He Huang, Depei Wu, Li Yu, Hanyun Ren, Xiaojun Huang, Xi Zhang
BACKGROUND: Antifungal prophylaxis is currently regarded as the gold standard in situations with allo-genetic hematopoietic stem cell transplantation (allo-HSCT). However, the epidemiological information regarding prophylaxis of invasive fungal diseases (IFDs) is not clear in China. METHODS: We report the first large-scale (1053 patients) observational study of the prophylaxis and management of IFDs among patients with allo-HSCT in China. RESULTS: The incidence rates of IFD after primary antifungal prophylaxis (PAP), secondary antifungal prophylaxis (SAP), and non-prophylaxis were 22...
2016: Journal of Hematology & Oncology
Ming-Ran Zhang, Tian-Hang Xie, Jun-Lin Chi, Yuan Li, Lie Yang, Yong-Yang Yu, Xiao-Feng Sun, Zong-Guang Zhou
The lymph node ratio (LNR) (i.e. the number of metastatic lymph nodes divided by the number of totally resected lymph nodes) has recently emerged as an important prognostic factor in colorectal cancer (CRC). However, the tumor node metastasis (TNM) staging system for colorectal cancer does not consider it as a prognostic parameter. Therefore, we conducted a meta-analysis to evaluate the prognostic role of the LNR in node positive CRC. A systematic search was performed in PubMed, Embase and the Cochrane Library for relevant studies up to November 2015...
September 20, 2016: Oncotarget
Nurul Paramita, Nury Nusdwinuringtyas, Siti Annisa Nuhonni, Tubagus Djumhana Atmakusuma, R Irawati Ismail, Tito R Mendoza, Charles S Cleeland
CONTEXT: Cancer-related fatigue is one of the most commonly reported symptoms in cancer patients. Short but good assessment is essential to detect and manage this symptom. Brief Fatigue Inventory (BFI) is a valid and reliable short instrument to assess cancer-related fatigue. OBJECTIVE: To examine the validity and reliability of the Indonesian BFI. METHODS: Forward and backward translation approach, followed by cognitive debriefing process, was done to develop Indonesian BFI...
September 19, 2016: Journal of Pain and Symptom Management
Natasha Simonovska, Beti Zafirova-Ivanovska, Aleksandra Babulovska, Zanina Pereska, Irena Jurukov, Liljana Trenchevska-Siljanovska
OBJECTIVE: The incidence of autoantibodies may be associated with the duration of drug use. In this study, we assessed the association between the duration of heroin dependence and various humoral immunologic indicators, including IgA, IgG, IgM, complement component 3, complement component 4, rheumatoid factor, anti-β2-glycoprotein 1 (IgA, IgG, IgM), antinuclear antibody, circulating immune complexes, and cryoglobulins. METHODS: A total of 363 patients with heroin dependence were enrolled in this cross-sectional and prospective study over a 3...
September 8, 2016: Journal of Addiction Medicine
Nahid M Akhlaghi, Fatemeh Mashadi Abbas, Mostafa Mohammadi, Mohammad Reza Karami Shamloo, Orkideh Radmehr, Ramin Kaviani, Vahid Rakhshan
BACKGROUND: Root morphology is of utmost importance to endodontic sciences. Since there are a few studies on the morphology of mandibular second molars' roots, and some anatomical variables are not evaluated before, the aim of this study was to investigate thoroughly radicular anatomy of this tooth. MATERIALS AND METHODS: This ex vivo study was performed on 150 intact mandibular second molars. After access cavity preparation and ensuring canal patency, Indian ink was injected into root canals from the orifices...
July 2016: Dental Research Journal
DongMei He, XiuJuan Yang, FeiYu Wang, Chi Yang, MinJun Dong
Acute traumatic temporomandibular joint disc displacement (ATDD) and its sequelae are not familiar for most surgeons. This study is to discuss its sequelae in cases without disc reduction after failed conservative treatment. From 2010 to 2015, 26 patients with 34 joints were included in the study. All patients had at least 3 months conservative treatment. Their maximal incisor opening (MIO) was measured during follow-ups and MRI examination was used to check the condylar bone degeneration. The mean follow-up for conservative treatment after admission was 8...
2016: Scientific Reports
Małgorzata Polz-Dacewicz, Małgorzata Strycharz-Dudziak, Jakub Dworzański, Agnieszka Stec, Joanna Kocot
BACKGROUND: Each year approximately 6,000 new cases of head and neck cancer are registered in Poland. Human papillomavirus (HPV) and Epstein-Barr virus (EBV) have been associated with tumour formation. Cytokines have been shown to play an important role both in inflammation and carcinogenesis and they can be detected in saliva and serum with ELISA assays. Salivary biomarkers may be used as markers of early cancer detection. The aim of this study was the analysis of the serum and salivary levels of IL-10, TNF-α, TGF-β and VEGF in patients with oropharyngeal cancer and in healthy individuals...
2016: Infectious Agents and Cancer
Hani Mansourian, Beth L Rubenstein, Craig Spencer, Makini Chisolm-Straker, Eva Noble, Anna Skeels, Chiara Ceriotti, Lindsay Stark
BACKGROUND: This article reports on the use of the 'neighborhood method' to measure the prevalence and basic characteristics of children who became separated from their parents or usual caregivers subsequent to an attack by the M23 militia group in North Kivu, Democratic Republic of the Congo. METHODS: A two-stage household cluster survey was conducted in 522 households in North Kivu in August 2014. Heads of households were asked about separated children in their household, as well as the households of their two closest neighbors...
2016: Conflict and Health
Viola A Dohvoma, Emilienne Epée, Stève R Ebana Mvogo, N Sandra Lietcheu, Côme Ebana Mvogo
PURPOSE: To study the relationship between exophthalmometric value (EV) and refractive error in Cameroonian young adults. PATIENTS AND METHODS: A prospective descriptive study was carried out in the ophthalmic unit of the Yaoundé Central Hospital from March to May 2015. Consenting patients aged 20-40 years with no intraocular pathology who were seen for refractive errors were included. Ocular protrusion was measured using the Hertel exophthalmometer. Automatic refraction was done following cycloplegia with cyclopentolate and tropicamide...
2016: Clinical Ophthalmology
Aleksander Pawluś, Marcin Inglot, Mariusz Chabowski, Kinga Szymańska, Małgorzata Inglot, Mateusz Patyk, Joanna Słonina, Filipe Caseiro-Alves, Dariusz Janczak, Urszula Zaleska-Dorobisz
OBJECTIVE: The aim of the study was to compare the elasticity of the spleen in patients with hepatitis B and C but without liver fibrosis with that of healthy subjects using a shear wave elastography (SWE) examination. METHODS: Between December 2014 and December 2015, 35 patients with hepatitis B virus (HBV) infections and 45 patients with (hepatitis C virus) HCV infections and liver stiffness below 7.1 kPa were included in the study. The control group was composed of 53 healthy volunteers without any chronic liver disease, with no abnormal findings in their ultrasound examinations and with an SWE of the liver below 6...
October 2016: British Journal of Radiology
Allison Squires, S Jennifer Uyei, Hiram Beltrán-Sánchez, Simon A Jones
BACKGROUND: A key component to achieving good patient outcomes is having the right type and number of healthcare professionals with the right resources. Lack of investment in infrastructure required for producing and retaining adequate numbers of health professionals is one reason, and contextual factors related to socioeconomic development may further explain the trend. Therefore, this study sought to explore the relationships between country-level contextual factors and healthcare human resource production (defined as worker-to-population ratio) across 184 countries...
2016: Human Resources for Health
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