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Intraocular pressure

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https://www.readbyqxmd.com/read/29332128/pharmacologic-characterization-of-omidenepag-isopropyl-a-novel-selective-ep2-receptor-agonist-as-an-ocular-hypotensive-agent
#1
Tomoko Kirihara, Takazumi Taniguchi, Kenzo Yamamura, Ryo Iwamura, Kenji Yoneda, Noriko Odani-Kawabata, Atsushi Shimazaki, Takeshi Matsugi, Naveed Shams, Jin-Zhong Zhang
Purpose: The objective of this study was to investigate the pharmacologic characteristics of omidenepag isopropyl (OMDI), a compound developed as a novel intraocular pressure (IOP)-lowering agent, with better IOP control and fewer side effects than other prostanoid receptor agonists such as prostaglandin F receptor (FP) agonists. Methods: Binding activities of OMDI and its hydrolyzed form, omidenepag (OMD), to human recombinant prostanoid receptors (DP1-2, EP1-4, FP, and IP) were evaluated...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29331952/inter-relationship-between-ocular-perfusion-pressure-blood-pressure-intraocular-pressure-profiles-and-primary-open-angle-glaucoma-the-singapore-epidemiology-of-eye-diseases-study
#2
Yih-Chung Tham, Sing-Hui Lim, Preeti Gupta, Tin Aung, Tien Y Wong, Ching-Yu Cheng
OBJECTIVE: To elucidate the inter-relationship between ocular perfusion pressure (OPP), blood pressure (BP), intraocular pressure (IOP) profiles and primary open-angle glaucoma (POAG) in a multiethnic Asian population. METHODS: Participants were recruited from the Singapore Epidemiology of Eye Diseases Study and underwent standardised ocular and systemic examinations. POAG was defined according to the International Society for Geographical and Epidemiological Ophthalmology criteria...
January 13, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29329136/glaucoma-implant-tube-lumen-obstruction-visualized-using-anterior-segment-optical-coherence-tomography
#3
Shunsuke Nakakura, Asuka Noguchi, Santaro Noguchi, Yuka Hirose, Koji Niimi, Hitoshi Tabuchi, Yoshiaki Kiuchi
We report a case of glaucoma implant tube lumen obstruction visualized with anterior segment optical coherence tomography (ASOCT) and present its surgical management. The patient was a 66-year-old man with refractory glaucoma associated with traumatic aphakia in the right eye after trabeculectomy, several bleb needling procedures, and scleral fixation of the intraocular lens with pars plana vitrectomy. Finally, we performed Baerveldt implantation at the pars plana of the temporal inferior quadrant with a several Sherwood slit...
January 11, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29328064/south-african-eye-study-saes-ethnic-differences-in-central-corneal-thickness-and-intraocular-pressure
#4
S O Baboolal, D P Smit
PurposeGlaucoma is the leading cause of irreversible blindness worldwide. South Africa has a diverse population but there is a lack of published ethnic specific normative data. The purpose of the study is to determine the distribution of intraocular pressure (IOP) and central corneal thickness (CCT) values in a multi-ethnic South African population and to determine additional systemic and ocular factors that influence IOP and CCT.Patients and methodsThis cross-sectional study included a total of 402 participants with 706 eyes aged 18-94 years...
January 12, 2018: Eye
https://www.readbyqxmd.com/read/29323543/effects-of-molsidomine-on-retinal-ischemia-reperfusion-injury-in-rabbits
#5
N Polat, M A Ozer, H Parlakpinar, N Vardi, Z Aksungur, O Ozhan, A Yildiz, Y Turkoz
We investigated the effect of molsidomine (MOL) on ischemia/reperfusion (I/R) injury. Rabbits were assigned to four groups: group 1, sham; group 2, I/R; group 3, MOL treatment for 4 days after I/R; group 4, MOL treatment for 1 day before I/R and 3 days after I/R. Retinal I/R was produced by elevating the intraocular pressure to 150 mm Hg for 60 min. Seven days after I/R, the eyes were enucleated. Retinal changes were examined using histochemistry. The levels of malondialdehyde (MDA), glutathione (GSH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) also were measured...
January 11, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/29319544/review-of-the-xen-gel-stent-and-innfocus-microshunt
#6
Wesley Green, John T Lind, Arsham Sheybani
PURPOSE OF REVIEW: Two new translimbal glaucoma devices (Xen Gel Stent and InnFocus MicroShunt) have been developed with the goal of optimizing the predictability and safety for subconjunctival glaucoma surgery. RECENT FINDINGS: The new subconjunctival glaucoma implants are manufactured from nonsilicone, biocompatible materials, which may reduce the postoperative inflammatory and fibrotic reactions that can lead to failure. Early data suggests a favorable safety profile with significant reductions in intraocular pressure (IOP)...
January 9, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29315442/changes-in-corneal-biomechanical-properties-with-different-corneal-cross-linking-irradiances
#7
FangJun Bao, YaRu Zheng, Chang Liu, XiaoBo Zheng, YiPing Zhao, Yuan Wang, LinNa Li, QinMei Wang, ShiHao Chen, Ahmed Elsheikh
PURPOSE: To evaluate whether different corneal cross-linking (CXL) irradiances, all with the same delivered total energy, achieve similar increases in corneal material stiffness. METHODS: One hundred twenty-six healthy white Japanese rabbits were randomly divided into seven groups (n = 18 each). After removing the epithelium of the left corneas, six groups were exposed to riboflavin (0.22% concentration by volume) and ultraviolet-A (370 nm) at different CXL irradiations, all with the same total dose (5...
January 1, 2018: Journal of Refractive Surgery
https://www.readbyqxmd.com/read/29311618/choroidal-vascularity-index-in-type-2-diabetes-analyzed-by-swept-source-optical-coherence-tomography
#8
Mirinae Kim, Min Ji Ha, Seung Yong Choi, Young-Hoon Park
The relationships between changes in choroidal vasculature and the severity of diabetic retinopathy (DR) remain unclear. We assessed choroidal changes in diabetic patients by measuring choroidal vascularity index (CVI) in conjunction with DR stage. In this study, patients with diabetes and healthy controls were retrospectively analyzed. Subjects were divided into seven groups as follows: Healthy controls, no DR, mild/moderate non-proliferative DR (NPDR), severe NPDR, proliferative DR (PDR), panretinal photocoagulation-treated DR, and clinically significant macular edema...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29310962/glaucomatous-optic-neuropathy-associated-with-nocturnal-dip-in-blood-pressure-findings-from-the-maracaibo-aging-study
#9
Jesús D Melgarejo, Joseph H Lee, Michele Petitto, Juan B Yépez, Felipe A Murati, Zhezhen Jin, Carlos A Chávez, Rosa V Pirela, Gustavo E Calmón, Winston Lee, Matthew P Johnson, Luis J Mena, Lama A Al-Aswad, Joseph D Terwilliger, Rando Allikmets, Gladys E Maestre, C Gustavo De Moraes
PURPOSE: To determine which nocturnal blood pressure (BP) parameters (low levels or extreme dipper status) are associated with an increased risk of glaucomatous damage in Hispanics. DESIGN: Observational cross-sectional study. PARTICIPANTS: A subset (n = 93) of the participants from the Maracaibo Aging Study (MAS) who met the study eligibility criteria were included. These participants, who were at least 40 years of age, had measurements for optical tomography coherence, visual field (VF) tests, 24-hour BP, office BP, and intraocular pressure <22 mmHg...
January 5, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29310612/impending-extrusion-of-ex-press-shunt-treated-by-shunt-position-adjustment-a-case-report
#10
Yong Ju Song, Sumi Kim, Gil Joong Yoon
BACKGROUND: To report a case of impending extrusion of Ex-PRESS shunt treated by shunt-position adjustment. CASE PRESENTATION: A 56-year-old Asian woman presented with impending extrusion and malposition of Ex-PRESS shunt in her left eye. The bleb of the left eye was shallow and diffuse. In the past, the patient was treated by Ex-PRESS shunt implantation under the scleral flap in both eyes. There had been no Ex-PRESS shunt-related complication in her right eye, and she reported no history of left-eye trauma...
January 8, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29310481/nanostructured-lipid-carriers-for-intraocular-brimonidine-localization-development-in-vitro-and-in-vivo-evaluation
#11
Noha S El-Salamouni, Ragwa M Farid, Amal H El-Kamel, Safaa S El-Gamal
Brimonidine ocular hypotensive effect can be enhanced by increasing residence time and corneal penetration. The current work aimed to formulate, evaluate and compare nanostructured lipid carriers (NLCs) to solid lipid nanoparticles (SLNs) and commercial eye drops for controlled brimonidine delivery. NLCs prepared by modified high shear homogenization were spherical with a mean size of 151.97 ±1.98 nm, negative zeta potential (ZP) of -44.2± 7.81 mV, % entrapment efficiency (EE) of 83.631 ±0.495% and low crystallinity index (CI) (17...
January 9, 2018: Journal of Microencapsulation
https://www.readbyqxmd.com/read/29310395/delayed-onset-of-pressure-induced-interlamellar-stromal-keratitis-in-a-patient-with-recurrent-uveitis-a-case-report
#12
Che-Yuan Kuo, Yu-Fan Chang, Yu-Bai Chou, Chih-Chien Hsu, Pei-Yu Lin, Catherine Jui-Ling Liu
INTRODUCTION: Corticosteroid treatment for uveitis can lead to delayed-onset pressure-induced interlamellar stromal keratitis (PISK), even years after laser in situ keratomileusis (LASIK).A 35-year-old man presented to our clinic after experiencing blurred vision in his left eye for 1 month. For the past month, he had been prescribed topical steroid and anti-glaucomatous medication. He had undergone LASIK for both eyes 5 years earlier, and had suffered uveitis attacks in his left eye over the last 2 years...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29305716/comparative-outcomes-of-trabeculotomy-ab-externo-versus-trabecular-ablation-ab-interno-for-open-angle-glaucoma
#13
Eri Kinoshita-Nakano, Hideo Nakanishi, Hanako Ohashi-Ikeda, Satoshi Morooka, Tadamichi Akagi
PURPOSE: To compare clinical outcomes between trabeculotomy ab externo (TLO) and trabecular ablation ab interno using a Trabectome (TAT) for open angle glaucoma (OAG). STUDY DESIGN: Prospective and retrospective cohort study. METHODS: We prospectively recruited 68 patients who underwent TAT between May 2013 and July 2015, and retrospectively recruited 59 patients who underwent TLO between April 2010 and May 2013. We included OAG patients who could be followed up for more than 12 months after surgery...
January 5, 2018: Japanese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29305369/radius-maumenee-syndrome-a-rare-cause-of-glaucoma
#14
Sara Homem de Melo Marques, Cláudia Farinha, Amélia Martins, Pedro Faria
Case presentation of a 41-year-old woman with long-standing bilateral eye injection whose clinical findings included bilateral episcleral vessel engorgement and tortuosity, raised intraocular pressure with open iridocorneal angles and left optic disc cupping. All remaining objective examination was normal. She underwent cranial and orbits CT and CT-angiography scans which were unremarkable. Optical coherence tomography of the peripapillary nerve fibre layer and automated perimetry were compatible with advanced glaucomatous damage on the left eye...
January 5, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29305310/a-prospective-longitudinal-study-to-investigate-corneal-hysteresis-as-a-risk-factor-for-predicting-development-of-glaucoma
#15
Carolina N Susanna, Alberto Diniz-Filho, Fábio B Daga, Bianca N Susanna, Feilin Zhu, Nara G Ogata, Felipe A Medeiros
PURPOSE: To investigate the role of corneal hysteresis (CH) as a risk factor for development of glaucoma. DESIGN: Prospective observational cohort study. METHODS: Two-hundred and eighty-seven eyes of 199 patients suspected of having glaucoma followed for an average of 3.9 ± 1.8 years. All eyes had normal visual fields at baseline. Development of glaucoma was defined as occurrence of 3 consecutive abnormal standard automated perimetry tests during follow-up, defined as pattern standard deviation (PSD) <5%, and/or Glaucoma Hemifield Test outside normal limits...
January 2, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29303886/anterior-segment-parameters-in-patients-with-wilson-disease
#16
Necip Kara, Sevim Ayca Seyyar, Oguzhan Saygili, Mustafa Seyyar, Murat Taner Gulsen, Kıvanc Gungor
PURPOSE: To investigate anterior segment parameters in patients with Wilson disease (WD). METHODS: In this cross-sectional study, 22 patients with WD (study group) and 22 healthy subjects (control group) were enrolled. Each participant underwent a comprehensive ophthalmic assessment including best-corrected visual acuity, slit-lamp biomicroscopy, fundus examination, and intraocular pressure. Anterior segment parameters were measured by the Sirius anterior segment analyzer system (Costruzione Strumenti Oftalmici, Florence, Italy)...
January 4, 2018: Cornea
https://www.readbyqxmd.com/read/29303880/ab-interno-tube-occlusion-for-postoperative-hypotony-in-a-patient-with-an-ahmed-glaucoma-drainage-device
#17
Max Feinstein, Kareem Moussa, Ying Han
PURPOSE: To report a case of Ahmed glaucoma valve-induced hypotony that was successfully managed with postoperative intraluminal stenting of the aqueous shunt tube. PATIENT AND METHODS: We describe a 68-year-old male with advanced uveitic glaucoma with an intraocular pressure (IOP) of 25▒mm Hg in the left eye. The patient initially responded well to an Ahmed glaucoma valve implant, but at 10 weeks post-implantation, the patient underwent cataract surgery and developed persistent hypotony, choroidal folds, and decreased vision...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303878/intraocular-pressure-after-phacoemulsification-in-open-angle-glaucoma-patients-with-uncontrolled-or-marginally-controlled-glaucoma-and-or-with-severe-visual-field-loss
#18
Karine D Bojikian, Philip P Chen
BACKGROUND/AIMS: To evaluate intraocular pressure (IOP) after phacoemulsification in open angle glaucoma (OAG) patients with uncontrolled or marginally controlled glaucoma and/or severe visual field (VF) loss. METHODS: Retrospective case series of OAG patients without prior glaucoma surgery undergoing phacoemulsification. Uncontrolled or marginally controlled glaucoma was defined as IOP>21▒mm Hg despite maximally tolerated medications or requiring more than 3 topical drugs for IOP control...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303877/trypan-blue-for-the-assessment-of-filtering-bleb-function-during-cataract-surgery
#19
Edward Stephen Yung, Marlene R Moster, Carina Sanvicente, John Pluta, Kamran Rahmatnejad, Arjun S Patel, Alice Williams, Ben Abramowitz, L Jay Katz, Michael Pro
PURPOSE: Phacoemulsification has been cited as a possible cause of bleb failure in eyes with prior trabeculectomy. No method has been developed to directly evaluate the risk of bleb failure after phacoemulsification. We investigate the use of trypan blue during cataract surgery in the setting of a pre-existing trabeculectomy to evaluate the functional status of the bleb and predict post-operative bleb function. PATIENTS AND METHODS: 14 patients contributing one eye each with a history of prior trabeculectomy with mitomycin C undergoing phacoemulsification with intraocular lens implantation were enrolled in this prospective, nonrandomized clinical trial...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303876/optical-coherence-tomography-angiography-description-of-ocular-decompression-retinopathy-after-deep-sclerectomy-in-traumatic-glaucoma
#20
Lauriane Salinas, Ankita Chaudhary, Kaweh Mansouri
PURPOSE: To present a case of ocular decompression retinopathy (ODR) occurring after uncomplicated deep sclerectomy with Mitomycin C using optical coherence tomography angiography (OCTA). PATIENT AND METHOD: Single case report. RESULTS: A 55-year-old man with traumatic glaucoma in the right eye complained of blurred vision. Visual acuity was 20/25 and intraocular pressure (IOP) was 50▒mm Hg. Deep sclerectomy with Mitomycin C was performed...
January 4, 2018: Journal of Glaucoma
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