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Intraocular pressure

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https://www.readbyqxmd.com/read/28938016/a-feed-forward-regulation-of-endothelin-receptors-by-c-jun-in-human-non-pigmented-ciliary-epithelial-cells-and-retinal-ganglion-cells
#1
Junming Wang, Hai-Ying Ma, Raghu R Krishnamoorthy, Thomas Yorio, Shaoqing He
c-Jun, c-Jun N-terminal kinase(JNK) and endothelin B (ETB) receptor have been shown to contribute to the pathogenesis of glaucoma. Previously, we reported that an increase of c-Jun and CCAAT/enhancer binding protein β (C/EBPβ) immunohistostaining is associated with upregulation of the ETB receptor within the ganglion cell layer of rats with elevated intraocular pressure (IOP). In addition, both transcription factors regulate the expression of the ETB receptor in human non-pigmented ciliary epithelial cells (HNPE)...
2017: PloS One
https://www.readbyqxmd.com/read/28937876/pilot-study-of-the-pulsatile-neuro-peripapillary-retinal-deformation-in-glaucoma-and-its-relationship-with-glaucoma-risk-factors
#2
Maribel Hidalgo-Aguirre, Santiago Costantino, Mark Richard Lesk
PURPOSE: To perform a pilot study of the neuro-peripapillary retinal tissue deformation during the cardiac cycle among healthy eyes, ocular hypertensive (OHT), open angle glaucoma suspect (OAG-S), and early open angle glaucoma (EOAG) patients using video rate optical coherence tomography (OCT) image series. METHODS: OCT line scan sequences of the same region of the optic nerve head (ONH) were obtained from 15 EOAG, 6 OHT, 10 OAG-S, and 10 healthy age-matched eyes...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937830/simvastatin-as-an-adjunct-to-conventional-therapy-of-non-infectious-uveitis-a-randomized-open-label-pilot-study
#3
Ivan V Shirinsky, Anastasia A Biryukova, Valery S Shirinsky
PURPOSE: Statins have been shown to reduce ocular inflammation in animal models of uveitis and to prevent development of uveitis in observational studies. There have been no experimental human studies evaluating statins' efficacy and safety in uveitis. In this study, we aimed to investigate efficacy and safety of simvastatin in patients with uveitis. METHODS: For this single-center, open-label, randomized study, we enrolled patients with acute non-infectious uveitis...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937823/optic-disc-parameters-of-myopic-children-with-atropine-treatment
#4
Li-Wei Chan, Yi-Ting Hsieh, Wei-Cherng Hsu, Han-Chih Cheng, Elizabeth P Shen
PURPOSE: To characterize optic disc parameters, retinal nerve fiber layer thickness (RNFLT), and the intraocular pressure (IOP) of myopic children under continual topical 0.25% atropine treatment. METHODS: From October 1, 2010 to September 31, 2011, 67 eyes of 35 myopic children were recruited. The children were treated with 0.25% atropine nightly for myopia control. Visual acuity, refraction, IOP, axial length (AL, IOL Master), RNFLT, and optic disc parameters (Stratus OCT) were measured at enrollment and every 2 months...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28937506/role-of-lens-extraction-and-laser-peripheral-iridotomy-in-treatment-of-glaucoma
#5
Sara Pose-Bazarra, Augusto Azuara-Blanco
PURPOSE OF REVIEW: Lens extraction in people with coexisting cataract and open angle glaucoma is associated with a reduction in intraocular pressure (IOP). In primary angle-closure glaucoma (PACG), lens extraction and laser peripheral iridotomy (LPI) can be used to open the anterior chamber angle, increase the outflow through the trabecular meshwork and reduce the IOP. The present review will summarize the recent available literature regarding the role of both interventions for the treatment of glaucoma...
September 20, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28936366/constitutive-and-stress-induced-expression-of-ccl5-machinery-in-rodent-retina
#6
D'Anne S Duncan, William M McLaughlin, Noah Vasilakes, Franklin D Echevarria, Cathryn R Formichella, Rebecca M Sappington
Signaling by inflammatory cytokines and chemokines is associated with neurodegeneration in disease and injury. Here we examined expression of the β-chemokine CCL5 and its receptors in the mouse retina and evaluated its relevance in glaucoma, a common optic neuropathy associated with sensitivity to intraocular pressure (IOP). Using quantitative PCR, fluorescent in situ hybridization, immunohistochemistry and quantitative image analysis, we found CCL5 mRNA and protein was constitutively expressed in the inner retina and synaptic layers...
June 2017: Journal of Clinical & Cellular Immunology
https://www.readbyqxmd.com/read/28936163/quercetin-declines-apoptosis-ameliorates-mitochondrial-function-and-improves-retinal-ganglion-cell-survival-and-function-in-in-vivo-model-of-glaucoma-in-rat-and-retinal-ganglion-cell-culture-in-vitro
#7
Feng-Juan Gao, Sheng-Hai Zhang, Ping Xu, Bo-Qi Yang, Rong Zhang, Yun Cheng, Xu-Jiao Zhou, Wan-Jing Huang, Min Wang, Jun-Yi Chen, Xing-Huai Sun, Ji-Hong Wu
Glaucoma is a progressive neuropathy characterized by the loss of retinal ganglion cells (RGCs). Strategies that delay or halt RGC loss have been recognized as potentially beneficial for rescuing vision in glaucoma patients. Quercetin (Qcn) is a natural and important dietary flavonoid compound, widely distributed in fruits and vegetables. Mounting evidence suggests that Qcn has numerous neuroprotective effects. However, whether Qcn exerts neuroprotective effects on RGC in glaucoma is poorly understood. In this study, we investigated the protective effect of Qcn against RGC damage in a rat chronic ocular hypertension (COHT) model invivo and hypoxia-induced primary cultured RGC damage in vitro, and we further explored the underlying neuroprotective mechanisms...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28936052/outcome-of-descemet-stripping-automated-endothelial-keratoplasty-in-failed-penetrating-keratoplasty
#8
Abdulrahman S Khairallah
PURPOSE: The purpose of this study was to report the outcomes of descemet stripping automated endothelial keratoplasty (DSAEK) surgeries in eyes with failed penetrating keratoplasty (PKP). METHODS: This was a retrospective, noncomparative, descriptive case series. Patients who underwent DSAEK following PKP from January 2007 to December 2012 were reviewed. Data were collected on best-corrected visual acuity (BCVA) before and 1 week, 1 month, 3 months, 6 months, 1 year, and 2 years following DSAEK...
April 2017: Middle East African Journal of Ophthalmology
https://www.readbyqxmd.com/read/28934261/light-entrainment-of-the-murine-intraocular-pressure-circadian-rhythm-utilizes-non-local-mechanisms
#9
Shunsuke Tsuchiya, Ethan D Buhr, Tomomi Higashide, Kazuhisa Sugiyama, Russell N Van Gelder
PURPOSE: Intraocular pressure (IOP) is known to have a strong circadian rhythm, yet how light/dark cycles entrain this rhythm is unknown. The purpose of this study was to assess whether, like the retina, the mammalian ciliary body and IOP clocks have an intrinsic ability to entrain to light/dark cycles. METHODS: Iris-ciliary body complexes were obtained from period2:luciferase (PER2::LUC) mice and cultured to measure bioluminescence rhythmicity. Pairs of the iris-ciliary body complex were exposed to antiphasic 9:15 h light/dark cycle in vitro...
2017: PloS One
https://www.readbyqxmd.com/read/28933957/the-upright-body-position-increases-translaminar-pressure-gradient-in-normotensive-and-hypertensive-rats
#10
Janusz Skrzypecki, Marcin Ufnal
AIM: Several lines of evidence suggest that the pathogenesis of glaucoma may depend on an increased translaminar pressure gradient (TPG), the difference between intraocular and intracranial pressure (ICP), rather than on intraocular pressure (IOP) itself. It has also been suggested that high blood pressure might correlate with the incidence of glaucoma; however, the data are contradictory. Here, we studied the effect of arterial blood pressure and changes in body position on TPG in rats...
September 21, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28933042/anterior-chamber-changes-after-implantable-collamer-lens-implantation-in-high-myopia-using-pentacam-a-prospective-study
#11
Mohamed Nagy Elmohamady, Walid Abdelghaffar
INTRODUCTION: The objective of this study was to evaluate the changes of the anterior chamber (AC) of the eye after implantable Collamer lens (ICL) implantation in high myopia by using the Pentacam. METHODS: The prospective study included 34 high myopic patients (34 eyes). All patients were treated with Visian implantable Collamer lens (ICL) (Staar Surgical Co.) implantation. The Pentacam (Oculus) was used for all cases preoperatively and 1, 3 and 6 months postoperatively...
September 20, 2017: Ophthalmology and Therapy
https://www.readbyqxmd.com/read/28932753/effect-of-iop-based-infusion-system-with-and-without-balanced-phaco-tip-on-cumulative-dissipated-energy-and-estimated-fluid-usage-in-comparison-to-gravity-fed-infusion-in-torsional-phacoemulsification
#12
Praveen K Malik, Taru Dewan, Arun Kr Patidar, Ekta Sain
BACKGROUND: To evaluate the effect of three different combinations of tip designs and infusion systems in torsional phacoemulsification (INFINITI and CENTURION) in patients with cataract. According to the manufacturer, two unique improvements in the Centurion are: active fluid dynamic management system and use of an intrepid balanced tip. The study specifically aimed to evaluate the beneficial effects, if any, of change in tip design and infusion system individually and in combination on both per-operative parameters as well as endothelial health over 6 months...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28931299/-steroid-induced-glaucoma-as-a-complication-of-atopic-eczema-local-treatment
#13
T Řeháková, A Stepanov, N Jirásková
The authors present case reports of two young women, who visited the outpatient Department of Ophthalmology clinic, University Hospital in Hradec Králové with lacklustre subjective eye complaints lasting over few weeks. It the beginning high values of intraocular pressure in both eyes and severe glaucomatous damage of the optic nerve head were find out, which was confirm using perimetry and OCT (optical coherence tomography). The anamnesis has shown that both patients have been treated for atopic eczema since their childhood...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931297/-intracranial-pressure-evaluation-by-ophthalmologist
#14
J Čmelo, R Illéš, J Šteňo
The value of ICT is important in diagnosis of the diseases of the eye and orbit Methods for direct measurement of intracranial pressure (ICT) are exact, but they are invasive and there is some risk of infection and damage of the tissue. Currently there are 2 valid indirect methods of mesurement of IKT. Digital Ophthalmodynamometry (D-ODM) and Transcranial Doppler ultrasonography (TDU). D-ODM is a non-invasive method for measuring of the Pulsating Venous Pressure (VPT). We can measure VPT by the pulse phenomena...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931296/-translaminar-gradient-and-glaucoma
#15
J Čmelo
OBJECTIVE: The cribriform plate is a threshold of the intraocular pressure (VOT) and of the intracranial pressure (IKT). The difference between the VOT and IKT is referred to as translaminar gradient (TLG). The goal was to evaluate the Glaucoma progression (visual field, fundus examination, HRT) with / without topical anti-glaucomatous therapy) in relation to the TLG. PATIENTS AND METHODS: the significance of TLG has been studied in two groups. I. Group: 57 patients diagnosed and treatment of Primary Open-Angle Glaucoma (PGOU), 10 patients with Ocular hypertension (OH), 7 patients with Normal-Tension Glaucoma (NTG), and 75 healthy without glaucoma...
2017: Ceská a Slovenská Oftalmologie
https://www.readbyqxmd.com/read/28931182/-primary-open-angle-glaucoma
#16
Esther M Hoffmann, Verena Prokosch-Willing
Glaucoma leads to blindness but there are diagnostic and therapeutic developments that aid ophthalmologists in the improved mangement of the disease compared to the past. Known risk factors such as age, myopia, dark pigmented skin, genetics, and elevated intraocular pressure play an important role for the individual patient's prognosis, and many yet unknown or not sufficiently investigated risk factors come along. The structured examination of the optic nerve head is crucial for the clincial diagnosis by the ophthalmologist...
September 20, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28931008/biometric-and-structural-ocular-manifestations-of-marfan-syndrome
#17
Petra Gehle, Barbara Goergen, Daniel Pilger, Peter Ruokonen, Peter N Robinson, Daniel J Salchow
BACKGROUND: To study biometric and structural ocular manifestations of Marfan syndrome (MFS). METHODS: Observational, retrospective, comparative cohort study in a tertiary referral center on 285 MFS patients and 267 controls. Structural and biometric ocular characteristic were compared. RESULTS: MFS eyes were longer (axial length 24.25 ± 1.74 mm versus 23.89 ± 1.31 mm, p < 0.001) and had a flatter cornea than control eyes (mean keratometry 41...
2017: PloS One
https://www.readbyqxmd.com/read/28930887/genetic-variant-near-plxdc2-influences-the-risk-of-primary-open-angle-glaucoma-by-increasing-intraocular-pressure-in-the-japanese-population
#18
Fumihiko Mabuchi, Nakako Mabuchi, Mitsuko Takamoto, Yoichi Sakurada, Seigo Yoneyama, Kenji Kashiwagi, Hiroyuki Iijima, Zentaro Yamagata, Makoto Aihara, Takeshi Iwata, Makoto Araie
PURPOSE: To assess the association between the genetic variants that were previously reported to be associated with primary open-angle glaucoma (POAG) in the Japanese population and the phenotypic features. METHODS: Six hundred sixty-one Japanese patients including 417 patients with POAG (normal tension glaucoma [NTG], n=210; high tension glaucoma [HTG], n=207) and 244 control subjects without glaucoma were analyzed for 3 genetic variants: rs547984 (near gene: ZP4), rs7081455 (PLXDC2), and rs7961953 (TMTC2)...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28930885/author-response-regarding-simultaneous-implantation-of-an-ahmed-and-baerveldt-glaucoma-drainage-device-for-uncontrolled-intraocular-pressure-in-advanced-glaucoma
#19
Veena Rao, Pratap Challa
No abstract text is available yet for this article.
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28930381/intraocular-pressure-and-big-bubble-diameter-in-deep-anterior-lamellar-keratoplasty-an-ex-vivo-microscope-integrated-oct-with-heads-up-display-study
#20
Paramjit K Bhullar, Oscar M Carrasco-Zevallos, Alexandria Dandridge, Neel D Pasricha, Brenton Keller, Liangbo Shen, Joseph A Izatt, Cynthia A Toth, Anthony N Kuo
PURPOSE: To investigate the relationship between intraocular pressure (IOP) and big bubble (BB) formation in a model of deep anterior lamellar keratoplasty (DALK). DESIGN: Ex-vivo. METHODS: Corneoscleral buttons from human donors were loaded onto an artificial anterior chamber connected to a column of balanced salt solution. A surgeon-in-training learned to perform DALK via the BB technique using swept-source microscope-integrated optical coherence tomography (SS-MIOCT) with heads-up display (HUD)...
September 2017: Asia-Pacific Journal of Ophthalmology
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