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Intraocular pressure

Chukai Huang, Lijing Xie, Zhenggen Wu, Yingjie Cao, Yuqian Zheng, Chi-Pui Pang, Mingzhi Zhang
Juvenile onset open-angle glaucoma (JOAG) affects patients before 40 years of age, causing high intraocular pressure and severe optic nerve damage. To expand the mutation spectrum of the causative genes in JOAG, with a view to identify novel disease-causing mutations, we investigated MYOC, OPTN, NTF4, WDR36 and CYP1B1 in a cohort of 67 unrelated Chinese JOAG patients. Whole exome sequencing was used to identify possible pathogenic mutations, which were further excluded in normal controls. After sequencing and the use of a database pipeline, as well as predictive assessment filtering, we identified a total of six mutations in three genes, MYOC, OPTN and CYP1B1...
March 14, 2018: Scientific Reports
Ayse Ipek Akyuz Unsal, Yesim Basal, Serap Birincioglu, Tolga Kocaturk, Harun Cakmak, Alparslan Unsal, Gizem Cakiroz, Nüket Eliyatkın, Ozden Yukselen, Buket Demirci
PURPOSE: To investigate the potential effects of chronic exposure to a nasal decongestant and its excipients on ocular tissues using an experimental rat model. METHODS: Sixty adult male Wistar rats were randomized into six groups. The first two groups were control (serum physiologic) and Otrivine® groups. The remaining four groups received the Otrivine excipients xylometazoline, benzalkonium chloride, sorbitol, and ethylene diamine tetra acetic acid. Medications were applied into both nostrils twice a day for 8 weeks...
January 2018: Arquivos Brasileiros de Oftalmologia
Kadriye Erkan Turan, Hande Taylan Sekeroglu, Ata Baytaroglu, Figen Bezci, Sevilay Karahan
PURPOSE: To (a) determine the normative values for optical coherence tomography (OCT) parameters such as central macular thickness, retinal nerve fiber layer thickness, and choroidal thickness in healthy children; (b) investigate the relationships of these parameters with axial length, central corneal thickness, refractive errors, and intraocular pressure; and (c) determine interexaminer agreement for choroidal thickness measurements. METHODS: In this cross-sectional study, 120 healthy children aged 8-15 years underwent detailed ophthalmological examination and OCT measurements...
January 2018: Arquivos Brasileiros de Oftalmologia
Ulrike Hampel, Katharina Träger, Hanhan Liu, Julia Teister, Franz Grus, Verena Prokosch-Willing
PURPOSE: Recently, the vasodilator relaxin 2 has been introduced as a treatment for acute heart failure. However, its role on vessels of the eye and intraocular pressure (IOP) remains unclear though it has been hypothesized to induce a decrease IOP after intramuscular injection in humans. We aimed to test whether the hormone relaxin 2 lowers IOP and dilates retinal vessels in animals. METHODS: The IOP of female Sprague-Dawley rats before and after application of relaxin 2 was measured using an Icare Tonolab device calibrated for rats...
March 13, 2018: International Ophthalmology
Sunil S Adav, Jin Wei, Jingru Qian, Nicola Yi'An Gan, Leonard W L Yip, Siu Kwan Sze
PURPOSE: Primary angle-closure glaucoma (PACG) is associated with increased intraocular pressure, optic nerve damage, and progressive vision loss, but the molecular mechanism that underpins retinal ganglion neuropathy in PACG remains poorly understood. To better understand the pathogenesis of human PACG, we performed the first comprehensive proteomic analysis of aqueous humor (AH) samples from PACG patients and matched control donors to study pathogenic alteration in AH composition in disease...
March 13, 2018: International Ophthalmology
Ji-Yeon Lee, Su-Ja Oh
The retinal degeneration resulting from elevated intraocular pressure was evaluated through functional and morphological analyses, for better understanding of the pathophysiology of glaucoma. Ocular hypertension was induced via unilateral episcleral venous cauterization in rats. Experimental time was set at 1 and 3 days, and 1, 2, 4, and 8 weeks post-operation. Retinal function was analyzed using electroretinography. For morphological analysis, retinal tissues were processed for immunochemistry by using antibodies against the calcium-sensing receptor and calcium-binding proteins...
February 2018: Experimental Neurobiology
Gyu Ah Kim, Si Hyung Lee, Sang Yeop Lee, Hee Jung Kwon, Hyoung Won Bae, Gong Je Seong, Chan Yun Kim
PURPOSE: Surgically induced astigmatism (SIA) has attracted much interest in recent times because changes in corneal astigmatism can lead to decreased uncorrected visual acuity and patient discomfort. This study aimed to evaluate SIA and to identify factors correlated therewith after trabeculectomy. METHODS: We retrospectively reviewed medical charts of patients who were treated with trabeculectomy at 120° meridian (superotemporal area on right eye and superonasal area on left eye) by the same surgeon...
March 14, 2018: Eye
Urmimala Raychaudhuri, J Cameron Millar, Abbot F Clark
Glaucoma is a vision threatening optic neuropathy that affects millions of people worldwide. In primary open angle, increased intraocular pressure (IOP) is the main risk factor for the development of this disease. Studies investigating the causes and mechanisms of increased IOP show fibrotic changes in the trabecular meshwork (TM) that are different from those of age-matched controls. Tissue transglutaminase (TGM2), an extracellular matrix (ECM) crosslinking enzyme, covalently crosslinks ECM proteins and causes excessive ECM protein deposition in the TM that could cause increased IOP...
March 10, 2018: Experimental Eye Research
Hung-Ju Chen, Chin Lin, Cho-Hao Lee, Yi-Hao Chen
AIM: The objective of this study was to evaluate the efficacy and safety of bevacizumab combined with antimetabolite as an adjunctive therapy in primary trabeculectomy for glaucoma. MATERIALS AND METHODS: PubMed, Cochrane Library, and EMBASE were searched for relevant randomized controlled trials. Efficacy was evaluated by the postoperative mean intraocular pressure (IOP), complete success, and qualified success rates. Safety was evaluated by postoperative complications and surgical interventions...
March 13, 2018: Ophthalmic Research
Kevin Taliaferro, Alexander Crawford, Justin Jabara, Jonathan Lynch, Edward Jung, Raimonds Zvirbulis, Trevor Banka
BACKGROUND: Intraarticular steroid injections are a common first-line therapy for severe osteoarthritis, which affects an estimated 27 million people in the United States. Although topical, oral, intranasal, and inhalational steroids are known to increase intraocular pressure in some patients, the effect of intraarticular steroid injections on intraocular pressure has not been investigated, to the best of our knowledge. If elevated intraocular pressure is sustained for long periods of time or is of sufficient magnitude acutely, permanent loss of the visual field can occur...
March 9, 2018: Clinical Orthopaedics and related Research
Heng Sun, Zhu-Lin Hu
PURPOSE: To evaluate the safety and effectiveness of a modified polymethyl methacrylate-silicone keratoprosthesis and its operation method in alkali-burned rabbit model. METHODS AND MATERIALS: The polymethyl methacrylate-silicone keratoprostheses were implanted into seven alkali-burned rabbit corneas by a special operation method using autologous graft as the keratoprosthesis (Kpro) carrier. The long-term postoperative outcomes were evaluated. RESULTS: During a postoperative study period of 16 months, except for one Kpro extruded at 3 months, all Kpros were in good position and were kept transparent without Kpro extrusion, keratolysis, infection, endophthalmitis, or retinal detachment...
March 1, 2018: International Journal of Artificial Organs
Kyoko Ishida, Naoya Moroto, Kazuhiro Murata, Tetsuya Yamamoto
The publisher regrets that the original version.
March 12, 2018: Japanese Journal of Ophthalmology
Nehat Baftiu, Islam Krasniqi, Kastriot Haxhirexha, Rudin Domi
BACKGROUND: Tracheal extubations may be performed before or after awakening from anaesthesia. The advantage of extubation during anaesthesia may avoid all the unpleasant effects of fully awake extubation such as severe hypertension and tachycardia, malignant dysrhythmias, myocardial ischemia laryngospasm, and cough induced high intraocular and intracranial pressure. AIM: To show the current practice of performing extubations in Kosovo, as well as the advantage and disadvantage in performing this procedure in an awake patient or inpatient in light anaesthesia...
February 15, 2018: Open Access Macedonian Journal of Medical Sciences
A Walkden, J Huxtable, M Senior, H Lee, S Naylor, S Turner, K Ivanova, J Koppens, B Todd, A Macleod, F Sii, N Anand, P Shah, A King, D C Broadway, J F Kirwan, A McNaught, A Bhan-Bhargava
OBJECTIVES: To define the safety profile of trainee trabeculectomy surgery in the United Kingdom. Surgical exposure for trainees in England is limited due to service requirements, the European working time directive constraints and increasing sub-specialisation of glaucoma surgery. Limited knowledge exists on the outcomes of supervised glaucoma surgery. The aim is to determine the safety of supervised trabeculectomy surgery performed by trainee ophthalmologists. METHODS: Retrospective case note review of all patients that had trabeculectomy surgery with MMC by consultant and trainee surgeons across multiple UK centres...
March 12, 2018: Eye
Kate E Keller, Sanjoy K Bhattacharya, Theresa Borrás, Thomas M Brunner, Sunee Chansangpetch, Abbott F Clark, W Michael Dismuke, Yiqin Du, Michael H Elliott, C Ross Ethier, Jennifer A Faralli, Thomas F Freddo, Rudolf Fuchshofer, Michael Giovingo, Haiyan Gong, Pedro Gonzalez, Alex Huang, Murray A Johnstone, Paul L Kaufman, Mary J Kelley, Paul A Knepper, Casey C Kopczynski, John G Kuchtey, Rachel W Kuchtey, Markus H Kuehn, Raquel L Lieberman, Shan C Lin, Paloma Liton, Yutao Liu, Elke Lütjen-Drecoll, Weiming Mao, Marisse Masis-Solano, Fiona McDonnell, Colleen M McDowell, Darryl R Overby, Padmanabhan P Pattabiraman, Vijay K Raghunathan, P Vasanth Rao, Douglas J Rhee, Uttio Roy Chowdhury, Paul Russell, John R Samples, Donald Schwartz, Evan B Stubbs, Ernst R Tamm, James C Tan, Carol B Toris, Karen Y Torrejon, Janice A Vranka, Mary K Wirtz, Thomas Yorio, Jie Zhang, Gulab S Zode, Michael P Fautsch, Donna M Peters, Ted S Acott, W Daniel Stamer
Cultured trabecular meshwork (TM) cells are a valuable model system to study the cellular mechanisms involved in the regulation of conventional outflow resistance and thus intraocular pressure; and their dysfunction resulting in ocular hypertension. In this review, we describe the standard procedures used for the isolation of TM cells from several animal species including humans, and the methods used to validate their identity. Having a set of standard practices for TM cells will increase the scientific rigor when used as model, and enable other researchers to replicate and build upon previous findings...
March 8, 2018: Experimental Eye Research
Violeta Trejo-Reveles, Lynn McTeir, Kim Summers, Joe Rainger
Precise anterior segment (AS) development in the vertebrate eye is essential for maintaining ocular health throughout life. Disruptions to genetic programs can lead to severe structural AS disorders at birth, while more subtle AS defects may disrupt the drainage of ocular fluids and cause dysregulation of intraocular pressure homeostasis, leading to progressive vision loss. To date, the mouse has served as the major model to study AS development and pathogenesis. Here we present an accurate histological atlas of chick AS formation throughout eye development, with a focus on the formation of drainage structures...
March 8, 2018: Mechanisms of Development
Gaurav Mathur, Narottama Sindhu, Deependra Vikram Singh, Gurpreet Singh Garcha
PURPOSE: To present a unique case of decompression retinochoroidopathy presenting with intraretinal, subretinal and preretinal hemorrhages. METHODS: A 65-year-old hypertensive female presented with diminution of vision in right eye of 1-week duration. She had been a known case of primary open-angle glaucoma and had undergone trabeculectomy with mitomycin C in right eye 1 week back. Her day 1 postoperative intraocular pressure was 6 mmHg. Her left eye had undergone Ahmed glaucoma valve surgery for the same 2 years back...
March 10, 2018: International Ophthalmology
Ken Hayashi, Motoaki Yoshida, Tatsuhiko Sato, Shin-Ichi Manabe, Koichi Yoshimura
PURPOSE: To examine whether intraocular pressure (IOP) increases immediately after cataract surgery in eyes with pseudoexfoliation (PXF) syndrome and to assess whether orally administered acetazolamide can prevent the IOP elevation. SETTING: Hayashi Eye Hospital, Fukuoka, Japan. DESIGN: Prospective case series. METHODS: Patients with PXF syndrome scheduled for phacoemulsification were randomly assigned to 1 of 3 groups: (1) oral acetazolamide administered 1 hour preoperatively (preoperative administration group), (2) administered 3 hours postoperatively (postoperative administration group), and (3) not administered (no administration group)...
March 7, 2018: Journal of Cataract and Refractive Surgery
Ali Hariri, Junxin Wang, Yeji Kim, Anamik Jhunjhunwala, Daniel L Chao, Jesse V Jokerst
Chorioretinal imaging has a crucial role for the patients with chorioretinal vascular diseases, such as neovascular age-related macular degeneration. Imaging oxygen gradients in the eye could better diagnose and treat ocular diseases. Here, we describe the use of photoacoustic ocular imaging (PAOI) in measuring chorioretinal oxygen saturation (CR  -  sO2) gradients in New Zealand white rabbits (n  =  5) with ocular ischemia. We observed good correlation (R2  =  0.98) between pulse oximetry and PAOI as a function of different oxygen percentages in inhaled air...
March 2018: Journal of Biomedical Optics
Vivian L Qin, Mona Kaleem, Felipe F Conti, Edward J Rockwood, Annapurna Singh, Shalini Sood-Mendiratta, Jonathan E Sears, Fabiana Q Silva, Jonathan Eisengart, Rishi P Singh
PURPOSE: To compare long-term surgical outcomes and complications of pars plana (PP) tube implantation with conventional anterior chamber (AC) tube implantation. METHODS: Records of patients undergoing glaucoma tube implant surgery at a single institution between 2007-2015 were retrospectively reviewed. Eyes were matched for glaucoma diagnosis and patient age. Demographics, baseline characteristics, and treatment outcomes were recorded. Surgical success was defined as intraocular pressure (IOP) between 6-21▒mm Hg, no subsequent glaucoma surgeries performed, and at least light perception vision...
March 8, 2018: Journal of Glaucoma
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