Massimo Federico, Catherine Fortpied, Yana Stepanishyna, Manuel Gotti, Richard van der Maazen, Caterina Cristinelli, Alessandro Re, Wouter Plattel, Julien Lazarovici, Francesco Merli, Lena Specht, Jean-Marc Schiano de Colella, Martin Hutchings, Annibale Versari, Véronique Edeline, Aspasia Stamatoulas, Theodore Girinsky, Umberto Ricardi, Berthe Aleman, Bart Meulemans, Sanne Tonino, John Raemaekers, Marc André
Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported. The primary analysis of the Early positron emission tomography (ePET) Response-Adapted Treatment in localized Hodgkin Lymphoma H10 Trial demonstrated that in ePET-negative patients, the risk of relapse increased when involved-node radiotherapy (INRT) was omitted and that in ePET-positive patients, switching from doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) to bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPPesc) significantly improved 5-year progression-free survival (PFS)...
January 1, 2024: Journal of Clinical Oncology