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https://www.readbyqxmd.com/read/28812769/multiplex-coaxial-flow-focusing-for-producing-multicompartment-janus-microcapsules-with-tunable-material-compositions-and-structural-characteristics
#1
Qiang Wu, Chaoyu Yang, Guangli Liu, Wanghuai Xu, Zhiqiang Zhu, Ting Si, Ronald X Xu
We propose a simple but efficient multiplex coaxial flow focusing (MCFF) process for single-step fabrication of multicompartment Janus microcapsules (MJMs) in a wide range of operating parameters. The produced MJMs consist of a multicompartmental core-shell structure with material compositions tunable in individual shell and core compartments. Potential applications of such a MJM agent are demonstrated in both benchtop and in vitro experiments. For the benchtop experiment, magnetic nanoparticles are loaded into one of the shell compartments and photopolymerized under ultraviolet light for controlled alignment and rotation of the microcapsules in a magnetic field...
August 16, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28810762/phase-diagram-of-janus-particles-the-missing-dimension-of-pressure-anisotropy
#2
Hossein Rezvantalab, Daniel J Beltran-Villegas, Ronald G Larson
Brownian dynamics simulations of single-patch Janus particles under sedimentation equilibrium reveal that the phases found at fixed temperature and volume fraction are extremely sensitive to small changes in lateral box dimension. We trace this sensitivity to an uncontrolled parameter, namely, the pressure component parallel to the hexagonally ordered layers formed through sedimentation. We employ a flexible-cell constant-pressure scheme to achieve explicit control over this usually overlooked parameter, enabling the estimation of phase behavior under given pressure anisotropy...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810635/curcumin-protects-against-acute-renal-injury-by-suppressing-jak2-stat3-pathway-in-severe-acute-pancreatitis-in-rats
#3
Shuaijun Zhu, Chi Zhang, Qinyong Weng, Bing Ye
The aim of the present study was to investigate the effect of curcumin on acute renal injury in a rat model of severe acute pancreatitis (SAP). A SAP model with acute kidney injury was established in rats by retrograde injection of 5% sodium taurocholate into the pancreatic duct. The serum amylase, creatinine (Cr) and blood urea nitrogen (BUN) levels in rats were measured. Hematoxylin and eosin staining was used to assess pancreatic and renal histological changes. Serum tumor necrosis factor (TNF)-α and interleukin (IL)-6 levels were measured using ELISA kits...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28806720/exploration-of-acute-genotoxic-effects-and-antigenotoxic-potential-of-gambogic-acid-using-allium-cepa-assay
#4
Abhishek Shetty, Thejaswini Venkatesh, Padmanaban S Suresh, Rie Tsutsumi
The plant derived xanthanoid gambogic acid (GA) is well known for its anticancer activity. To date, biological actions of GA on plant system have not been reported. In the present study, we evaluated the potential acute genotoxic activity of GA, and its antigenotoxic potential against H2O2 induced genetic damage using Allium cepa root chromosomal aberration assay under hydroponic conditions. There was a significant decrease in the percentage of mitotic index/prophase index with the increase in clastogenicity percentage in a dose and time-dependent manner when Allium cepa bulbs were exposed to GA at 0...
August 5, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28803692/a-janus-faced-im30-ring-involved-in-thylakoid-membrane-fusion-is-assembled-from-im30-tetramers
#5
Michael Saur, Raoul Hennig, Phoebe Young, Kristiane Rusitzka, Nadja Hellmann, Jennifer Heidrich, Nina Morgner, Jürgen Markl, Dirk Schneider
Biogenesis and dynamics of thylakoid membranes likely involves membrane fusion events. Membrane attachment of the inner membrane-associated protein of 30 kDa (IM30) affects the structure of the lipid bilayer, finally resulting in membrane fusion. Yet, how IM30 triggers membrane fusion is largely unclear. IM30 monomers pre-assemble into stable tetrameric building blocks, which further align to form oligomeric ring structures, and differently sized IM30 rings bind to membranes. Based on a 3D reconstruction of IM30 rings, we locate the IM30 loop 2 region at the bottom of the ring and show intact membrane binding but missing fusogenic activity of loop 2 mutants...
August 2, 2017: Structure
https://www.readbyqxmd.com/read/28803481/autonomous-collision-free-navigation-of-microvehicles-in-complex-and-dynamically-changing-environments
#6
Tianlong Li, Xiaocong Chang, Zhiguang Wu, Jinxing Li, Guangbin Shao, Xinghong Deng, Jianbin Qiu, Bin Guo, Guangyu Zhang, Qiang He, Longqiu Li, Joseph Wang
Self-propelled micro- and nanoscale robots represent a rapidly emerging and fascinating robotics research area. However, designing autonomous and adaptive control systems for operating micro-/nanorobotics in complex and dynamically-changing environments, which is a highly demanding feature, is still an unmet challenge. Here we describe a smart microvehicle for precise autonomous navigation in complicated environments and traffic scenarios. The fully autonomous navigation system of the smart microvehicle is composed of a microscope-coupled CCD camera, an artificial intelligence planner, and a magnetic field generator...
August 12, 2017: ACS Nano
https://www.readbyqxmd.com/read/28801915/manganese-and-1-methyl-4-phenylpyridinium-mpp-induced-neurotoxicity-indicate-differences-in-morphological-electrophysiological-and-genome-wide-alterations-implications-for-idiopathic-parkinson-s-disease
#7
Rajeswara Babu Mythri, Narayana Reddy Raghunath, Santosh Chandrakant Narwade, Mirazkar DasharathaRao Pandareesh, Kollarkandi Rajesh Sabitha, Mohamad Aiyaz, Bipin Chand, Manas Sule, Krittika Ghosh, Senthil Kumar, Bhagyalakshmi Shankarappa, Soundarya Soundararajan, Phalguni Anand Alladi, Meera Purushottam, Narayanappa Gayathri, Deepti Dileep Deobagkar, Thenkanidiyoor Rao Laxmi, Srinivas Bharath Muchukunte Mukunda
Idiopathic Parkinson's disease (iPD) and manganese-induced atypical Parkinsonism are characterized by movement disorder and nigrostriatal pathology. Although clinical features, brain region involved and responsiveness to levodopa distinguish both, differences at the neuronal level are largely unknown. We studied the morphological, neurophysiological and molecular differences in dopaminergic neurons exposed to the PD toxin 1-methyl-4-phenylpyridinium ion (MPP(+) ) and manganese (Mn) followed by validation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Mn mouse models...
August 12, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28798799/central-administration-of-1-deoxynojirimycin-attenuates-hypothalamic-endoplasmic-reticulum-stress-and-regulates-food-intake-and-body-weight-in-mice-with-high-fat-diet-induced-obesity
#8
Jongwan Kim, Eun-Young Yun, Fu-Shi Quan, Seung-Won Park, Tae-Won Goo
The α-glucosidase inhibitor, 1-deoxynojirimycin (DNJ), is widely used for its antiobesity and antidiabetic effects. Researchers have demonstrated that DNJ regulates body weight by increasing adiponectin levels, which affects energy intake and prevents diet-induced obesity. However, the mechanism by which centrally administered DNJ exerts anorexigenic effects has not been studied until now. We investigated the effect of DNJ in the hypothalamus of mice with high-fat diet-induced obesity. Results showed that intracerebroventricular (ICV) administration of DNJ reduced hypothalamic ER stress, which activated the leptin-induced Janus-activated kinase 2 (JAK2)/signal transducers and activators of transcription 3 (STAT3) signaling pathway to cause appetite suppression...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28798794/optical-coherence-tomography-improves-the-results-of-balloon-pulmonary-angioplasty-in-inoperable-chronic-thrombo-embolic-pulmonary-hypertension
#9
Aleksander Araszkiewicz, Stanisław Jankiewicz, Magdalena Łanocha, Magdalena Janus, Tatiana Mularek-Kubzdela, Maciej Lesiak
No abstract text is available yet for this article.
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28792053/a-janus-oil-barrel-with-tapered-microhole-arrays-for-spontaneous-high-flux-spilled-oil-absorption-and-storage
#10
Zhen Zhang, Yinghui Zhang, Hua Fan, Yulong Wang, Chen Zhou, Feifei Ren, Sizhu Wu, Guoqiang Li, Yanlei Hu, Jiawen Li, Dong Wu, Jiaru Chu
Porous oil/water separation materials show excellent prospects in the remediation of oil spill accidents. However, several drawbacks such as low flux, limited absorption and storage capacity restrict their practical applications. Hence, a novel Janus oil barrel (superhydrophobic outside wall and superhydrophilic inside wall) constituted by tapered microhole arrayed aluminium foil is designed, which is demonstrated to be a promising device for the remediation of oil spill accidents. Furthermore, the investigation shows that the tapered microholes (taper angle 25-30°) can significantly enhance oil/water intrusion pressures (1-3 times higher than cylindrical holes) and unidirectional transferability which can eliminate the secondary leakage when salvaging full oil barrels without an additional procedure...
August 9, 2017: Nanoscale
https://www.readbyqxmd.com/read/28791654/pharmacotherapy-of-myelofibrosis
#11
REVIEW
Douglas Tremblay, Bridget Marcellino, John Mascarenhas
Myelofibrosis (MF) is a myeloproliferative neoplasm that is pathologically characterized by bone marrow myeloproliferation, reticulin and collagen fibrosis, and extramedullary hematopoiesis. Constitutive activation of the Janus associated kinase (JAK)-signal transducers and activators of transcription signaling pathway with resultant elevation in pro-inflammatory cytokine levels is the pathogenic hallmark of MF. JAK inhibitors, namely ruxolitinib, have been successful in alleviating symptoms and reducing splenomegaly, but therapy-related myelosuppression has led to the further development of highly selective JAK2 inhibitors...
August 8, 2017: Drugs
https://www.readbyqxmd.com/read/28791417/diverse-gene-expression-patterns-in-response-to-anticancer-drugs-between-human-and-mouse-cell-lines-revealed-by-a-comparative-transcriptomic-analysis
#12
Yong Guo, Zhuoran Liang, Xiaoliang Hou, Zhi Zhang
The aim of the present study was to perform comparative genomics using gene expression profile datasets of mice and humans who had been treated with anticancer drugs, to determine the similarities and differences in the antitumor mechanisms in the two mammals. This involved data mining of antitumor gene expression regulation, and screening of genetic loci from experimental mouse models of antitumor targets, to provide a theoretical basis of drug design. Subsequently, 9 overlapping genes with opposite expression patterns were identified across mouse and human cell lines that were treated with a specific cyclin‑dependent kinase 4/6 inhibitor, PD0332991...
August 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28790974/selective-inhibition-of-janus-kinase-3-has-no-impact-on-infarct-size-or-neurobehavioral-outcomes-in-permanent-ischemic-stroke-in-mice
#13
Kelly M DeMars, Sean C Pacheco, Changjun Yang, David M Siwarski, Eduardo Candelario-Jalil
Janus kinase 3 (JAK3) is associated with the common gamma chain of several interleukin (IL) receptors essential to inflammatory signaling. To study the potential role of JAK3 in stroke-induced neuroinflammation, we subjected mice to permanent middle cerebral artery occlusion and investigated the effects of JAK3 inhibition with decernotinib (VX-509) on infarct size, behavior, and levels of several inflammatory mediators. Results from our double immunofluorescence staining showed JAK3 expression on neurons, endothelial cells, and microglia/macrophages in the ischemic mouse brain (n = 3)...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28790099/gsk2586184-a-jak1-selective-inhibitor-in-two-patients-with-ulcerative-colitis
#14
Leonie C S De Vries, Valerie J Ludbrook, Kirsty J Hicks, Geert R D'Haens
Tofacitinib, a non-selective Janus kinase (JAK) inhibitor, is effective in inducing clinical and endoscopic remission in patients with active ulcerative colitis (UC). Tofacitinib inhibits cytokine signalling through blockade of JAK1, JAK2, JAK3 and tyrosine kinase 2 (TYK2). Adverse events including neutropenia and anaemia resulting from JAK2 inhibition have been observed in actively treated patients. By selectively targeting JAK1, such adverse events could be expected to be avoided. This open label study was designed to enrol 15 patients with UC, however the trial was discontinued after two inclusions due to safety concerns with the agent in a parallel trial for systemic lupus erythematosus...
August 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28789911/discovery-of-tricyclic-dipyrrolopyridine-derivatives-as-novel-jak-inhibitors
#15
Hiroaki Yamagishi, Takayuki Inoue, Yutaka Nakajima, Jun Maeda, Hiroaki Tominaga, Hiroyuki Usuda, Takeshi Hondo, Ayako Moritomo, Fumihiro Nakamori, Misato Ito, Koji Nakamura, Hiroki Morio, Yasuyuki Higashi, Masamichi Inami, Shohei Shirakami
Janus kinases (JAKs) play a crucial role in cytokine mediated signal transduction. JAK inhibitors have emerged as effective immunomodulative agents for the prevention of transplant rejection. We previously reported that the tricyclic imidazo-pyrrolopyridinone 2 is a potent JAK inhibitor; however, it had poor oral absorption due to low membrane permeability. Here, we report the structural modification of compound 2 into the tricyclic dipyrrolopyridine 18a focusing on reduction of polar surface area (PSA), which exhibits potent in vitro activity, improved membrane permeability and good oral bioavailability...
July 27, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/28780459/janus-enantiomorphous-nanomaterial-assembly-on-substrate-surfaces-for-chirality-dependent-cell-adhesion
#16
N S Kehr
A janus enantiomorphous nanomaterial assembly on substrate surfaces is prepared by depositing two different enantiomorphous nanomaterials (NMs) onto two different halves of the same glass substrate. This advanced construct allows us to simultaneously study and compare how the opposite biopolymer enantiomers functionalized onto the NM surfaces affect cell adhesion under exactly the same reaction conditions and at the same time, using a single biomaterial. Cell experiments show that cell adhesion to the Janus enantiomorphous NM assembly is chirality dependent when opposite enantiomers are examined on a single biomaterial...
July 29, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28780423/cinnamic-acid-derivatives-inhibit-hepatitis-c-virus-replication-via-the-induction-of-oxidative-stress
#17
Ryota Amano, Atsuya Yamashita, Hirotake Kasai, Tomoka Hori, Sayoko Miyasato, Setsu Saito, Hiromasa Yokoe, Kazunori Takahashi, Tomohisa Tanaka, Teruhime Otoguro, Shinya Maekawa, Nobuyuki Enomoto, Masayoshi Tsubuki, Kohji Moriishi
Several cinnamic acid derivatives have been reported to exhibit antiviral activity. In this study, we prepared 17 synthetic cinnamic acid derivatives and screened them to identify an effective antiviral compound against hepatitis C virus (HCV). Compound 6, one of two hit compounds, suppressed the viral replications of genotypes 1b, 2a, 3a, and 4a with EC50 values of 1.5-8.1 μM and SI values of 16.2-94.2. The effect of compound 6 on the phosphorylation of Tyr(705) in signal transducer and activator of transcription 3 (STAT3) was investigated because a cinnamic acid derivative AG490 was reported to suppress HCV replication and the activity of Janus kinase (JAK) 2...
August 2, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28780337/phosphomolybdic-acid-responsive-pickering-emulsions-stabilized-by-ionic-liquid-functionalized-janus-nanosheets
#18
Qing Bo Meng, Peng Yang, Tianyang Feng, Xuyang Ji, Qian Zhang, Daliang Liu, Shuyao Wu, Fuxin Liang, Zhaoliang Zheng, Xi-Ming Song
A type of ionic liquid functionalized high-aspect-ratio Janus SiO2 nanosheets (IL-Janus nanosheets), which possesses a side terminated by imidazolin salt groups and the opposite side terminated by phenyl groups, was prepared and its emulsification performance was investigated. The surface wettability of ionic liquid functionalized side could be tailored via simple anion exchanging, giving the amphiphilic or totally hydrophobic Janus nanosheets. The influence of several parameters including surface wettability, particle concentration, oil composition, oil-water ratio as well as initial location of the nanosheets on the stability, morphology and type of the Pickering emulsions (O/W or W/O) stabilized by the amphiphilic IL-Janus nanosheets was evaluated...
July 27, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28776999/facile-production-of-biodegradable-bipolymer-patchy-and-patchy-janus-particles-with-controlled-morphology-by-microfluidic-routes
#19
Ekanem E Ekanem, Zilin Zhang, Goran T Vladisavljević
Patchy and patchy Janus particles composed of poly(dl-lactic acid) (PLA) and polycaprolactone (PCL) regions were produced with a controlled size, patchiness, composition, and shape anisotropy by microfluidic emulsification and solvent evaporation. Isotropic particles composed of PCL patches embedded in the PLA matrix were produced from relatively small drops with a diameter of 14-25 μm because of the fast solvent extraction as a result of high interfacial area of the particles. Anisotropic patchy Janus particles were formed from large drops, 100-250 μm in diameter...
August 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28774029/tuning-amphiphilicity-of-particles-for-controllable-pickering-emulsion
#20
REVIEW
Zhen Wang, Yapei Wang
Pickering emulsions with the use of particles as emulsifiers have been extensively used in scientific research and industrial production due to their edge in biocompatibility and stability compared with traditional emulsions. The control over Pickering emulsion stability and type plays a significant role in these applications. Among the present methods to build controllable Pickering emulsions, tuning the amphiphilicity of particles is comparatively effective and has attracted enormous attention. In this review, we highlight some recent advances in tuning the amphiphilicity of particles for controlling the stability and type of Pickering emulsions...
November 8, 2016: Materials
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