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https://www.readbyqxmd.com/read/28943442/the-quest-for-exceptional-drug-solubilization-in-diluted-surfactant-solutions-and-consideration-of-residual-solid-state
#1
Wiebke Saal, Nicole Wyttenbach, Jochem Alsenz, Martin Kuentz
Solubility screening in different surfactant solutions is an important part of pharmaceutical profiling. A particular interest is in low surfactant concentrations that mimic the dilution of an oral dosage form. Despite of intensive previous research on solubilization in micelles, there is only limited data available at low surfactant concentrations and generally missing is a physical state analysis of the residual solid. The present work therefore studied 13 model drugs in 6 different oral surfactant solutions (0...
September 21, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28943337/near-atomic-resolution-structure-determination-in-over-focus-with-volta-phase-plate-by-cs-corrected-cryo-em
#2
Xiao Fan, Lingyun Zhao, Chuan Liu, Jin-Can Zhang, Kelong Fan, Xiyun Yan, Hai-Lin Peng, Jianlin Lei, Hong-Wei Wang
Volta phase plate (VPP) is a recently developed transmission electron microscope (TEM) apparatus that can significantly enhance the image contrast of biological samples in cryoelectron microscopy, and therefore provide the possibility to solve structures of relatively small macromolecules at high-resolution. In this work, we performed theoretical analysis and found that using phase plate on objective lens spherical aberration (Cs)-corrected TEM may gain some interesting optical properties, including the over-focus imaging of macromolecules...
September 8, 2017: Structure
https://www.readbyqxmd.com/read/28941404/development-of-a-simple-multi-residue-determination-method-of-80-veterinary-drugs-in-oplegnathus-punctatus-by-liquid-chromatography-coupled-to-quadrupole-orbitrap-mass-spectrometry
#3
Fei Zhao, Xin Gao, Zhixu Tang, Xin Luo, Miaomiao Wu, Jiachao Xu, Xiaoting Fu
A simple, rapid and sensitive multi-residue analytical method was developed and validated for 80 veterinary drugs in Oplegnathus punctatus using ultrahigh performance liquid chromatography-Orbitrap high resolution mass spectrometry (LC-HRMS). The analytes belong to 12 different families include benzimidazoles, β-lactams, lincosamides, macrolides, nitromidazoles, quinolones, sulfonamides and trimethoprim, tetracyclines, triphenylmethane dyes, amphenicols, nonsteroidal estrogens and steroid hormones. The sample preparation was optimized base on QuEChERS (quick, easy, cheap, effective, rugged and safe) procedure...
September 18, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28941275/reconstruction-of-lignin-and-hemicelluloses-by-aqueous-ethanol-anti-solvents-to-improve-the-ionic-liquid-acid-pretreatment-performance-of-arundo-donax-linn
#4
Tingting You, Ruizhen Wang, Xueming Zhang, Shri Ramaswamy, Feng Xu
Ionic liquid (IL)-acid pretreatment is known to not only enhance the enzymatic hydrolysis efficiency of lignocellulose but also to generate deposits on the surface of fiber by conventional water regeneration, which retard the increment. In this study, ethanol aqueous solution regeneration was developed as a new method to change the substrates characteristics for IL-acid pretreatment and their effects on the enzymatic hydrolysis were evaluated. Following the IL-acid reaction, the biomass slurry was subjected to ethanol aqueous solution at various concentration...
September 23, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28941141/evaluation-of-cutaneous-rejuvenation-associated-with-the-use-of-ortho-silicic-acid-stabilized-by-hydrolyzed-marine-collagen
#5
Célia Luiza Petersen Vitello Kalil, Valéria Campos, Stela Cignachi, Juliana Favaro Izidoro, Clarissa Prieto Herman Reinehr, Christine Chaves
BACKGROUND: Organic silicon plays an important role in dermal structure by promoting neocollagenesis. Thus, the supplementation of silicon in a highly bioavailable form can be used for skin rejuvenation. AIMS: This study aimed to evaluate skin changes associated with the use of ortho-silicic acid stabilized by hydrolyzed collagen. PATIENTS/METHODS: Patients were randomized to receive 600 mg of ortho-silicic acid stabilized by hydrolyzed collagen (group 1, n = 11) or placebo (group 2, n = 11) to be taken 15 minutes before breakfast for 90 days...
September 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28941066/orientation-induces-adsorption-of-the-hydrated-proton-at-the-air-water-interface
#6
Shavkat Mamatkulov, Christoph Allolio, Roland Netz, Douwe Jan Bonthuis
The surface tension of the air-water interface increases upon the addition of inorganic salts, implying a negative surface excess of ionic species. Most acids, however, induce a decrease in surface tension, indicating a positive surface excess of hydrated protons. In combination with the apparent negative charge at pure air-water interfaces derived from electrokinetic experiments, this experimental fact has presented a source of intense debate since the mid 19th century. Here, we calculate surface tensions and ionic surface propensities at air-water interfaces from classical thermodynamically consistent molecular dynamics simulations...
September 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28940663/a-novel-method-to-assess-the-potential-role-of-sweating-abnormalities-in-the-pathogenesis-of-ad
#7
Yurie Shimoda-Komatsu, Yohei Sato, Yoshimi Yamazaki, Ryo Takahashi, Tetsuo Shiohara
BACKGROUND: Although atopic dry skin is believed to be caused by defects in skin genes important for maintaining skin barrier function, the role of sweat in atopic dermatitis (AD) has been apparently underestimated. Given the great capacity of sweat to maintain and increase skin hydration, defective sweating responses may be a logical place to look for changes that predispose individuals to the disease. METHODS: We investigated how disease process and sweating defects progress from early asymptomatic stages to the onset of clinically apparent disease by employing the impression mold technique, which allows an accurate quantification of individual sweat gland/duct activity in relation to skin surface topography...
September 23, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28940640/bicarbonate-recycling-by-hif-1-dependent-carbonic-anhydrase-isoforms-9-and-12-is-critical-in-maintaining-intracellular-ph-and-viability-of-nucleus-pulposus-cells
#8
Elizabeth S Silagi, Zachary R Schoepflin, Erin L Seifert, Christophe Merceron, Ernestina Schipani, Irving M Shapiro, Makarand V Risbud
Intervertebral disc degeneration is a ubiquitous condition closely linked to chronic low-back pain. The health of the avascular nucleus pulposus (NP) plays a crucial role in the development of this pathology. We tested the hypothesis that a network comprising HIF-1α, Carbonic anhydrase (CA) 9 and 12 isoforms, and sodium-coupled bicarbonate cotransporters (NBCs) buffer intracellular pH through coordinated bicarbonate recycling. Contrary to the current understanding of NP cell metabolism, analysis of metabolic-flux data from Seahorse XF analyzer showed that CO2 hydration contributes a significant source of extracellular proton production in NP cells, with a smaller input from glycolysis...
September 23, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28940586/comparative-instrumental-evaluation-of-efficacy-and-safety-between-a-binary-and-a-ternary-system-in-chemexfoliation
#9
Norma Cameli, Maria Mariano, Marco Ardigò, Cristina Corato, Gianfranco De Paoli, Enzo Berardesca
OBJECTIVE: To instrumentally evaluate the efficacy and the safety of a new ternary system chemo exfoliating formulation (water-dimethyl isosorbide-acid) vs traditional binary systems (water and acid) where the acid is maintained in both the systems at the same concentration. METHODS: Different peelings (binary system pyruvic acid and trichloroacetic acid-TCA, and ternary system pyruvic acid and TCA) were tested on the volar forearm of 20 volunteers of both sexes between 28 and 50 years old...
September 20, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28940105/experimental-and-theoretical-studies-of-emodin-interacting-with-a-lipid-bilayer-of-dmpc
#10
REVIEW
Antonio R da Cunha, Evandro L Duarte, Hubert Stassen, M Teresa Lamy, Kaline Coutinho
Emodin is one of the most abundant anthraquinone derivatives found in nature. It is the active principle of some traditional herbal medicines with known biological activities. In this work, we combined experimental and theoretical studies to reveal information about location, orientation, interaction and perturbing effects of Emodin on lipid bilayers, where we have taken into account the neutral form of the Emodin (EMH) and its anionic/deprotonated form (EM(-)). Using both UV/Visible spectrophotometric techniques and molecular dynamics (MD) simulations, we showed that both EMH and EM(-) are located in a lipid membrane...
September 22, 2017: Biophysical Reviews
https://www.readbyqxmd.com/read/28940034/protective-effects-of-chymostatin-on-paraquat-induced-acute-lung-injury-in-mice
#11
Chen Yang, Hong-Wei Song, Wei Liu, Xue-Song Dong, Zhi Liu
This study aims to evaluate the role of chymostatin in paraquat-induced acute lung injury. Institute of Cancer Research mice were randomly distributed into the NS, DMSO, chymostatin, paraquat or chymostatin treatment groups. Six mice from each group were intraperitoneally injected with chloral hydrate at 0, 1, 2, 4, 8, 12, 24 and 48 h after treatment administration. Blood samples were collected through cardiac puncture. Lung tissues were stained with haematoxylin and eosin for the observation of lung histology...
September 22, 2017: Inflammation
https://www.readbyqxmd.com/read/28939402/improving-the-drug-release-of-naproxen-sodium-tablets-by-preparing-granules-and-tablets-with-a-preferred-mixing-ratio-of-hydrates
#12
Bär David, Debus Heiko, Grune Christian, Tosch Stephan, Fischer Wolfgang, Mäder Karsten, Imming Peter
Naproxen is a typical and well-known analgesic classified as non-steroidal anti-inflammatory drug (NSAID) and is commercialized as tablets or liquid-filled capsules. Naproxen is typically used as a sodium salt because of its better processability compared to Naproxen free acid. This entails hygroscopicity and gives rise to the existence of four different hydrates, which show polymorphic and pseudopolymorphic properties. Solid dosage forms containing Naproxen Sodium often have to be processed in an applicable dosage form by granulation and tablet compression...
September 19, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28939264/the-effects-of-a-hydrating-mask-compared-to-traditional-warm-compresses-on-tear-film-properties-in-meibomian-gland-dysfunction
#13
Jacqueline Tan, Lily Ho, Katherine Wong, Alma La, Sylbi Lee, Sarah Park, Larissa Tran, Fiona Stapleton
No abstract text is available yet for this article.
September 19, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28938231/examining-lysozyme-structures-on-polyzwitterionic-brush-surfaces
#14
Haoyu Wang, Pinar Akcora
Conformational structures of lysozyme at the interfaces of hydrophilic polymer poly[2-(methacryloyloxy)ethyl dimethyl-(3-sulfopropyl)ammonium hydroxide] (PMEDSAH), are examined to understand the role of protein-polymer interactions on the stability of lysozyme. This work underpins the effect of hydration layer on the structures of physically adsorbed lysozyme on PMEDSAH brushes. Hydrophilic nature and strength of hydration layers around brushes are controlled by varying the brush thickness and temperature. We measured that lysozyme is structurally less stable on 15nm thick hydrophilic PMEDSAH brushes at 75°C than at room temperature...
September 18, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28937522/ambulatory-high-dose-methotrexate-administration-in-pediatric-osteosarcoma-patients-at-a-single-institution-in-argentina
#15
Jose A Villegas Rubio, Walter Cacciavillano, Adriana Rose, Pedro Zubizarreta, Marcelo Scopinaro
BACKGROUND: The purpose of this study was to evaluate the feasibility and safety of ambulatory high-dose methotrexate (HDMTX) administration with oral hydration, alkalinization, and leucovorin rescue. HDMTX (12 g/m) was given intravenously over 4 hours after urine alkalinization. Families and patients were instructed to continue ambulatory oral hydration and alkalinization to monitor urine pH and to adjust bicarbonate according to our institution's treatment algorithm. Clinical status and MTX levels were controlled every 24 hours, and oral leucovorin dose was adjusted accordingly...
October 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28937227/low-temperature-decoupling-of-water-and-protein-dynamics-measured-by-neutron-scattering
#16
Antonio Benedetto
Water plays a major role in bio-systems, greatly contributing to determine their structure, stability and function. It is well know, for instance, that proteins require a minimum amount of water to be fully functional. Despite many years of intensive research, however, the detailed nature of protein-hydration water interactions is still partly unknown. The widely-accepted "protein dynamical transition" scenario is based on perfect coupling between the dynamics of proteins and that of their hydration water, which has never been probed in depth experimentally...
September 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28937222/variable-lysozyme-transport-dynamics-on-oxidatively-functionalized-polystyrene-films
#17
Nicholas Anthony Moringo, Hao Shen, Lawrence J Tauzin, Wenxiao Wang, Logan D C Bishop, Christy F Landes
Tuning protein adsorption dynamics at polymeric interfaces is of great interest to many biomedical and material applications. Functionalization of polymer surfaces is a common method to introduce application specific surface chemistries to a polymer interface. In this work single molecule fluorescence microscopy is utilized to determine the adsorption dynamics of lysozyme, a well-studied antibacterial protein, at the interface of polystyrene oxidized via UV exposure, oxygen plasma, and functionalized by ligand grafting to produce varying degrees of surface hydrophilicity, surface roughness, and induced oxygen content...
September 22, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28936777/phytosphingosine-enhances-moisture-level-in-human-skin-barrier-through-stimulation-of-the-filaggrin-biosynthesis-and-degradation-leading-to-nmf-formation
#18
Hyun Kyung Choi, Young Hoon Cho, Eun Ok Lee, Jin Wook Kim, Chang Seo Park
Phytosphingosine (PHS) is a sphingoid that is a key component of phytoceramides NP, AP and EOP. PHS has been known to have anti-inflammation and antimicrobial activities and to stimulate epidermal differentiation. In addition, it is reported that PHS treatment notably increased phytoceramide content in keratinocytes. In this study, we tried to investigate whether PHS has any effect on the maturation of corneocytes such as formation of cornified envelope and natural moisturizing factor (NMF) that is also an essential event during the formation of skin barrier, stratum corneum...
September 21, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28935253/effects-of-nerolidol-and-limonene-on-stratum-corneum-membranes-a-probe-epr-and-fluorescence-spectroscopy-study
#19
Sebastião Antonio Mendanha, Cássia Alessandra Marquezin, Amando Siuiti Ito, Antonio Alonso
The sesquiterpene nerolidol and the monoterpene limonene are potent skin-permeation enhancers that have also been shown to have antitumor, antibacterial, antifungal and antiparasitic activities. Because terpenes are membrane-active compounds, we used electron paramagnetic resonance (EPR) spectroscopy of three membrane spin labels combined with the fluorescence spectroscopy of three lipid probes to study the interactions of these terpenes with stratum corneum (SC) intercellular membranes. An experimental apparatus was developed to assess the lipid fluidity of hydrated SC membranes via the fluorescence anisotropy of extrinsic membrane probes...
September 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28934549/selective-electrodeposition-of-tantalum-v-oxide-electrodes
#20
Hamed Hajibabaei, Thomas W Hamann
Thin films of TaOxHy were cathodically electrodeposited from an aqueous solution containing Ta-IPA precursor and KNO3 as a sacrificial agent. It was shown that the deposition resulted from a precipitation reaction triggered by the local change of pH at the surface of working electrode. Combined structural and compositional analysis revealed that during the electrodeposition the oxidation state of tantalum remained constant, Ta(V). The as-deposited films are mesoporous amorphous tantalum oxide hydrate films, which can be converted to either pure Ta2O5 or Ta3N5 by high-temperature annealing in either air (or Ar) or ammonia, respectively...
September 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
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