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https://www.readbyqxmd.com/read/28812943/tear-osmolarity-is-sensitive-to-exercise-induced-fluid-loss-but-is-not-associated-with-common-hydration-measures-in-a-field-setting
#1
Justin J Holland, Michelle Ray, Christopher Irwin, Tina L Skinner, Michael Leveritt, Ben Desbrow
This investigation (i) examined changes in tear osmolarity in response to fluid loss that occurs with exercise in a field setting, and (ii) compared tear osmolarity with common field and laboratory hydration measures.  Sixty-three participants [age 27.8 ± 8.4 years, body mass 72.15 ± 10.61 kg] completed a self-paced 10 km run outside on a predetermined course. Body mass, tear fluid, venous blood and urine samples were collected immediately before and after exercise.  Significant (p < 0.001) reductions in body mass (1...
August 16, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28812864/billing-for-intravenous-hydration
#2
Cindy Hughes
No abstract text is available yet for this article.
July 2017: Family Practice Management
https://www.readbyqxmd.com/read/28812353/dopamine-incorporated-dual-bioactive-electroactive-shape-memory-polyurethane-elastomers-with-physiological-shape-recovery-temperature-high-stretchability-and-enhanced-c2c12-myogenic-differentiation
#3
Xin Zhao, Ruonan Dong, Baolin Guo, Peter X Ma
Soft tissue engineering needs elastic biomaterials not only mimicking the elasticity of soft tissue but also possessing multiple bioactivity to promote cell adhesion, proliferation and differentiation, which still remains ongoing challenges. Herein, we synthesized a series of dopamine-incorporated dual bioactive electroactive shape memory polyurethane elastomers by combining the properties of elastomeric poly(citric acid-co-polycaprolactone) (CA-PCL) polyurethane elastomer, bioactive dopamine (DA) and electroactive aniline hexamer (AH)...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28810996/rhabdomyolysis-after-crawling-military-training
#4
Danit Atias-Varon, Haggai Sherman, Ran Yanovich, Yuval Heled
INTRODUCTION: Rhabdomyolysis is a syndrome characterized by muscle necrosis followed by release of intracellular muscle contents into the circulation. Exertional rhabdomyolysis (ER) occurs in response to nonfamiliar and/or excessive, prolonged, or repetitive exercises, with eccentric characteristics. In military populations, due to the type of intense, all out physical loads, ER is a significant threat, particularly when training under heat stress. However, many other etiologies exist, and clinical presentations vary greatly...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810798/binding-energies-of-hydrated-cobalt-hydroxide-ion-complexes-a-guided-ion-beam-and-theoretical-investigation
#5
Rebecca A Coates, P B Armentrout
The sequential bond energies of CoOH(+)(H2O)x complexes, where x = 1-4, are measured by threshold collision-induced dissociation using a guided ion beam tandem mass spectrometer. The primary dissociation pathway for all reactants consists of loss of a single water molecule. This is followed by the sequential loss of additional water molecules at higher collision energies for the x = 2-4 complexes, whereas the x = 1 reactant loses the OH ligand competitively with the H2O ligand. The kinetic energy dependent cross sections for dissociation of CoOH(+)(H2O)x complexes are modeled to obtain 0 and 298 K binding energies...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810753/dynamical-transition-in-molecular-glasses-and-proteins-observed-by-spin-relaxation-of-nitroxide-spin-probes-and-labels
#6
Elena A Golysheva, Georgiy Yu Shevelev, Sergei A Dzuba
In glassy substances and biological media, dynamical transitions are observed in neutron scattering that manifests itself as deviations of the translational mean-squared displacement, 〈x(2)〉, of hydrogen atoms from harmonic dynamics. In biological media, the deviation occurs at two temperature intervals, at ∼100-150 K and at ∼170-230 K, and it is attributed to the motion of methyl groups in the former case and to the transition from harmonic to anharmonic or diffusive motions in the latter case. In this work, electron spin echo (ESE) spectroscopy-a pulsed version of electron paramagnetic resonance-is applied to study the spin relaxation of nitroxide spin probes and labels introduced in molecular glass former o-terphenyl and in protein lysozyme...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810663/different-properties-of-polysialic-acids-synthesized-by-the-polysialyltransferases-st8sia2-and-st8sia4
#7
Airi Mori, Masaya Hane, Yuki Niimi, Ken Kitajima, Chihiro Sato
Polysialic acid (polySia) is mainly found as a modification of neural cell adhesion molecule (NCAM) in whole embryonic brains, as well as restricted areas of adult vertebrate brains, including the hippocampus. PolySia shows not only repulsive effects on NCAM-involved cell-cell interactions due to its bulky and hydrated properties, but also attractive effects on the interaction with neurologically active molecules, which exerts a reservoir function. Two different polysialyltransferases, ST8SIA2 and ST8SIA4, are involved in the synthesis of polySia chains; however, to date, the differences of the properties between polySia chains synthesized by these two enzymes remain unknown...
September 1, 2017: Glycobiology
https://www.readbyqxmd.com/read/28810618/sivelestat-sodium-hydrate-improves-post-traumatic-knee-osteoarthritis-through-nuclear-factor-%C3%AE%C2%BAb-in-a-rat-model
#8
Xiaofeng Yu, Lijun Zhao, Zhiping Yu, Changzheng Yu, Jianfei Bi, Binglong Sun, Haibo Cong
As a specific inhibitor of neutrophil elastase, sivelestat sodium hydrate has primarily been used in the treatment of acute lung injury caused by various factors since its approval in 2002. Sivelestat sodium hydrate also improves post-traumatic knee osteoarthritis (KOA), although its underlying mechanisms of action have yet to be elucidated. The aim of the current study was to determine if sivelestat sodium hydrate improves post-traumatic KOA through nuclear factor (NF)-κB in a rat model. Treatment with sivelestat sodium hydrate significantly inhibited the induction of structural changes and significantly increased the vertical episode count and ipsilateral static weight bearing of the joint in KOA rats (all P<0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28809963/deciphering-environment-effects-in-peptide-bond-solvation-dynamics-by-experiment-and-theory
#9
Matthias Wohlgemuth, Mitsuhiko Miyazaki, Kohei Tsukada, Martin Weiler, Otto Dopfer, Masaaki Fujii, Roland Mitrić
Most proteins work in aqueous solution and the interaction with water strongly affects their structure and function. However, experimentally the motion of a specific single water molecule is difficult to trace by conventional methods, because they average over the heterogeneous solvation structure of bulk water surrounding the protein. Here, we provide a detailed atomistic picture of the water rearrangement dynamics around the -CONH- peptide linkage in the two model systems formanilide and acetanilide, which simply differ by the presence of a methyl group at the peptide linkage...
August 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28809838/easy-manipulation-of-architectures-in-protein-based-hydrogels-for-cell-culture-applications
#10
Nicholas Bodenberger, Dennis Kubiczek, Frank Rosenau
Hydrogels are recognized as promising materials for cell culture applications due to their ability to provide highly hydrated cell environments. The field of 3D templates is rising due to the potential resemblance of those materials to the natural extracellular matrix. Protein-based hydrogels are particularly promising because they can easily be functionalized and can achieve defined structures with adjustable physicochemical properties. However, the production of macroporous 3D templates for cell culture applications using natural materials is often limited by their weaker mechanical properties compared to those of synthetic materials...
August 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28809537/confined-water-structure-dynamics-and-thermodynamics
#11
Sudip Chakraborty, Hemant Kumar, Chandan Dasgupta, Prabal K Maiti
Understanding the properties of strongly confined water is important for a variety of applications such as fast flow and desalination devices, voltage generation, flow sensing, and nanofluidics. Confined water also plays an important role in many biological processes such as flow through ion channels. Water in the bulk exhibits many unusual properties that arise primarily from the presence of a network of hydrogen bonds. Strong confinement in structures such as carbon nanotubes (CNTs) substantially modifies the structural, thermodynamic, and dynamic (both translational and orientational) properties of water by changing the structure of the hydrogen bond network...
August 15, 2017: Accounts of Chemical Research
https://www.readbyqxmd.com/read/28809497/a-chlorinating-reagent-yields-vinyl-chlorides-with-high-regioselectivity-under-heterogeneous-gold-catalysis
#12
Shengzong Liang, Rene Ebule, Gerald B Hammond, Bo Xu
A novel chlorinating reagent with a high concentration of HCl has enabled the highly regioselective hydrochlorination of unactivated alkynes using a commercial nanogold catalyst. No overchlorination or hydration products were formed, and various functional groups were tolerated. This hydrochlorination method could be conducted under open air.
August 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28808284/molecular-rationale-behind-the-differential-substrate-specificity-of-bacterial-rnd-multi-drug-transporters
#13
Venkata Krishnan Ramaswamy, Attilio V Vargiu, Giuliano Malloci, Jürg Dreier, Paolo Ruggerone
Resistance-Nodulation-cell Division (RND) transporters AcrB and AcrD of Escherichia coli expel a wide range of substrates out of the cell in conjunction with AcrA and TolC, contributing to the onset of bacterial multidrug resistance. Despite sharing an overall sequence identity of ~66% (similarity ~80%), these RND transporters feature distinct substrate specificity patterns whose underlying basis remains elusive. We performed exhaustive comparative analyses of the putative substrate binding pockets considering crystal structures, homology models and conformations extracted from multi-copy μs-long molecular dynamics simulations of both AcrB and AcrD...
August 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808031/changes-in-aggregation-states-of-light-harvesting-complexes-as-a-mechanism-for-modulating-energy-transfer-in-desert-crust-cyanobacteria
#14
Leeat Bar Eyal, Reza Ranjbar Choubeh, Eyal Cohen, Ido Eisenberg, Carmen Tamburu, Márta Dorogi, Renata Ünnep, Marie-Sousai Appavou, Reinat Nevo, Uri Raviv, Ziv Reich, Győző Garab, Herbert van Amerongen, Yossi Paltiel, Nir Keren
In this paper we propose an energy dissipation mechanism that is completely reliant on changes in the aggregation state of the phycobilisome light-harvesting antenna components. All photosynthetic organisms regulate the efficiency of excitation energy transfer (EET) to fit light energy supply to biochemical demands. Not many do this to the extent required of desert crust cyanobacteria. Following predawn dew deposition, they harvest light energy with maximum efficiency until desiccating in the early morning hours...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28808008/mathematical-model-reveals-role-of-nucleotide-signaling-in-airway-surface-liquid-homeostasis-and-its-dysregulation-in-cystic-fibrosis
#15
Conner I Sandefur, Richard C Boucher, Timothy C Elston
Mucociliary clearance is composed of three components (i.e., mucin secretion, airway surface hydration, and ciliary-activity) which function coordinately to clear inhaled microbes and other foreign particles from airway surfaces. Airway surface hydration is maintained by water fluxes driven predominantly by active chloride and sodium ion transport. The ion channels that mediate electrogenic ion transport are regulated by extracellular purinergic signals that signal through G protein-coupled receptors. These purinoreceptors and the signaling pathways they activate have been identified as possible therapeutic targets for treating lung disease...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807643/-use-of-subcutaneous-route-for-comfort-care%C3%A2-in-neonatal-palliative-population-systematic-review-and-survey-of-practices-in-france
#16
N Pouvreau, J Tandonnet, O Tandonnet, L Renesme
INTRODUCTION: Subcutaneous hydration (hypodermoclysis) and drug administration is a widely used method of analgesic therapy in adult palliative care medicine. Very little is known about its use in neonatal medicine. Evidence-based guidelines do not exist due to a lack of data. In this study, the advantages of subcutaneous analgesic therapy in terms of comfort in neonatal palliative care situations were investigated. METHODS: This report details the results of a systematic review associated with a survey in neonatal intensive care units (NICUs) and pediatric palliative care departments (PPCTs) in France...
August 11, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28806566/volumetric-adsorptive-microsampling-liquid-chromatography-tandem-mass-spectrometry-assay-for-the-simultaneous-quantification-of-four-antibiotics-in-human-blood-method-development-validation-and-comparison-with-dried-blood-spot
#17
Sebastiano Barco, Elio Castagnola, Andrea Moscatelli, James Rudge, Gino Tripodi, Giuliana Cangemi
In this paper we show the development and validation of a volumetric absorptive microsampling (VAMS™)-LC-MS/MS method for the simultaneous quantification of four antibiotics: piperacillin-tazobactam, meropenem, linezolid and ceftazidime in 10μL human blood. The novel VAMS-LC-MS/MS method has been compared with a dried blood spot (DBS)-based method in terms of impact of hematocrit (HCT) on accuracy, reproducibility, recovery and matrix effect. Antibiotics were extracted from VAMS and DBS by protein precipitation with methanol after a re-hydration step at 37°C for 10min...
August 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28806537/effect-of-oral-hydration-on-external-cephalic-version-at-term
#18
Virna Franca Zobbi, Antonella Nespoli, Elisa Spreafico, Roberta Recalcati, Federica Loi, Antonietta Scian, Stefania Galimberti
OBJECTIVE: To evaluate the effect of oral hydration on the success rate of external cephalic version (ECV). DESIGN: Randomized controlled and single-blind trial. SETTING: Academic tertiary hospital with approximately 3,000 births annually. PARTICIPANTS: One hundred sixty-four women at a gestational age of at least 37 weeks with breech-presenting fetuses and normal amniotic fluid indexes (AFIs). METHODS: Participants were randomly assigned to drink 2000 ml or no more than 100 ml of water in the 2 hours before undergoing ECV...
August 11, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28806486/farmworker-vulnerability-to-heat-hazards-a-conceptual-framework
#19
Valerie Vi Thien Mac, Linda A McCauley
PURPOSE: To review factors that impact the effect of hot environments on the human body in order to develop a conceptual model of human biological response. METHODS: The organizing concept for the model development was the multilevel integration of three major factors, exposure to heat, sensitivity and adaptive capacity, and the heat stress response. Exposure of a vulnerable occupational group was used to illustrate the components of the model. FINDINGS: Components of this framework include the hazard (environmental heat stress), vulnerability factors (workplace exposure, sensitivity and adaptive capacity), and the heat stress response...
August 14, 2017: Journal of Nursing Scholarship
https://www.readbyqxmd.com/read/28806077/structural-studies-of-bulk-to-nano-size-niobium-oxides-with-correlation-to-their-acidity
#20
Hannah Theresa Kreissl, Molly Meng-Jung Li, Yung-Kang Peng, Keizo Nakagawa, Thomas Hooper, John V Hanna, Ashley M Shepherd, Tai-Sing Wu, Yun-Liang Soo, S C Edman Tsang
Hydrated niobium oxides are used as strong solid acids with a wide variety of catalytic applications, yet the correlations between structure and acidity remain unclear. New insights into the structural features giving rise to Lewis and Brønsted acid sites are presently achieved. It appears that Lewis acid sites can arise from lower coordinate NbO5 and in some cases NbO4 sites, which are due to the formation of oxygen vacancies in thin and flexible NbO6 systems. Such structural flexibility of Nb-O systems is particularly pronounced in high surface area nanostructured materials, including few-to monolayer or mesoporous Nb2O5*nH2O synthesized in the presence of stabilizers...
August 14, 2017: Journal of the American Chemical Society
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