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Newcastle disease virus

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https://www.readbyqxmd.com/read/29670609/enhanced-replication-of-virulent-newcastle-disease-virus-in-chicken-macrophages-is-due-to-polarized-activation-of-cells-by-inhibition-of-tlr7
#1
Pingze Zhang, Zhuang Ding, Xinxin Liu, Yanyu Chen, Junjiao Li, Zhi Tao, Yidong Fei, Cong Xue, Jing Qian, Xueli Wang, Qingmei Li, Tobias Stoeger, Jianjun Chen, Yuhai Bi, Renfu Yin
Newcastle disease (ND), caused by infections with virulent strains of Newcastle disease virus (NDV), is one of the most important infectious disease affecting wild, peridomestic, and domestic birds worldwide. Vaccines constructed from live, low-virulence (lentogenic) viruses are the most accepted prevention and control strategies for combating ND in poultry across the globe. Avian macrophages are one of the first cell lines of defense against microbial infection, responding to signals in the microenvironment...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29661124/newcastle-disease-virus-infection-in-quail
#2
Leonardo Susta, Diego Segovia, Timothy L Olivier, Kiril M Dimitrov, Ismaila Shittu, Valerie Marcano, Patti J Miller
Newcastle disease (ND), caused by virulent strains of Newcastle disease virus (NDV), is a devastating disease of poultry worldwide. The pathogenesis of ND in quail is poorly documented. To characterize the ability of virulent NDV strains to replicate and cause disease in quail, groups of 14 two-week-old Japanese quail ( Coturnix japonica) were experimentally inoculated with 108 EID50 (embryo infectious dose 50%) units of 1 of 4 virulent NDV strains: 2 isolated from quail ( N2, N23) and 2 from chickens ( Israel, Pakistan)...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29657407/intranasal-administration-of-inactivated-avian-influenza-virus-of-h5n1-subtype-vaccine-induced-systemic-immune-response-in-chicken-and-mice
#3
I N Suartha, G A A Suartini, I W Wirata, N M A R K Dewi, G N N Putra, G A Y Kencana, G N Mahardika
Aim: The need for non-parenteral administration of inactivated avian influenza virus of H5N1 subtype (AIV-H5N1) vaccine is paramount. Here, we provide preliminary data on the immune response of chicken and mice after intranasal administration of AIV-H5N1-inactivated vaccine with ISCOMS, Inmunair (INM), and combined ISCOMS and INM as an adjuvant. Materials and Methods: The AIV isolate of A/Chicken/Denpasar/01/2004 (H5N1) was cultivated in specific pathogen-free chicken eggs and inactivated with formaldehyde...
February 2018: Veterinary World
https://www.readbyqxmd.com/read/29626432/newcastle-disease-virus-strain-af2240-as-an-oncolytic-virus-a-review
#4
REVIEW
Jeevanathan Kalyanasundram, Aini Hamid, Khatijah Yusoff, Suet Lin Chia
The discovery of tumour selective virus-mediated apoptosis marked the birth of an alternative cancer treatment in the form of oncolytic viruses. Even though, its oncolytic efficiency was demonstrated more than 50 years ago, safety concerns which resulted from mild to lethal side effects hampered the progress of oncolytic virus research. Since the classical oncolytic virus studies rely heavily on its natural oncolytic ability, virus manipulation was limited, thereby, restricted efforts to improve its safety...
April 4, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29621357/oncolytic-effect-of-wild-type-newcastle-disease-virus-isolates-in-cancer-cell-lines-in-vitro-and-in-vivo-on-xenograft-model
#5
Kseniya S Yurchenko, Peipei Zhou, Anna V Kovner, Evgenii L Zavjalov, Lidiya V Shestopalova, Alexander M Shestopalov
Oncolyic virotherapy is one of the modern experimental techniques to treat human cancers. Here we studied the antitumor activity of wild-type Newcastle disease virus (NDV) isolates from Russian migratory birds. We showed that NDV could selectively kill malignant cells without affecting healthy cells. We evaluated the oncolytic effect of 44 NDV isolates in 4 histogenetically different human cell lines (HCT116, HeLa, A549, MCF7). The safety of the isolates was also tested in normal peripheral blood mononuclear (PBMC) cells...
2018: PloS One
https://www.readbyqxmd.com/read/29617900/development-and-application-of-a-sybr-green-real-time-pcr-for-detection-of-the-emerging-avian-leukosis-virus-subgroup-k
#6
Jian Chen, Zijun Zhao, Yangyijun Chen, Jie Zhang, Lifu Yan, Xiaocui Zheng, Ming Liao, Weisheng Cao
Avian leukosis virus subgroup K (ALV-K) is an emerging ALV tumor virus of chickens. We developed a SYBR green-based real-time polymerase chain reaction (PCR) assay for the rapid and economical detection of ALV-K in chicken flocks. The assay was specific for ALV-K and did not cross-react with other ALV subgroup or avian influenza virus, Newcastle disease virus, or Marek's Disease virus. The method was 100 times more sensitive than conventional PCR and 10 times more sensitive than the enzyme-linked immunosorbent assay (ELISA) for the P27 antigen...
March 28, 2018: Poultry Science
https://www.readbyqxmd.com/read/29614025/vitamin-e-supplementation-ameliorates-newcastle-disease-virus-induced-oxidative-stress-and-alleviates-tissue-damage-in-the-brains-of-chickens
#7
Zaib Ur Rehman, Xusheng Qiu, Yingjie Sun, Ying Liao, Lei Tan, Cuiping Song, Shengqing Yu, Zhuang Ding, Muhammad Munir, Venugopal Nair, Chunchun Meng, Chan Ding
Newcastle disease (ND), characterized by visceral, respiratory, and neurological pathologies, causes heavy economic loss in the poultry industry around the globe. While significant advances have been made in effective diagnosis and vaccine development, molecular mechanisms of ND virus (NDV)-induced neuropathologies remain elusive. In this study, we report the magnitude of oxidative stress and histopathological changes induced by the virulent NDV (ZJ1 strain) and assess the impact of vitamin E in alleviating these pathologies...
April 3, 2018: Viruses
https://www.readbyqxmd.com/read/29601508/deep-sequencing-based-transcriptome-profiling-reveals-avian-interferon-stimulated-genes-and-provides-comprehensive-insight-into-newcastle-disease-virus-induced-host-responses
#8
Weiwei Liu, Xusheng Qiu, Cuiping Song, Yingjie Sun, Chunchun Meng, Ying Liao, Lei Tan, Zhuang Ding, Xiufan Liu, Chan Ding
Newcastle disease virus (NDV) is an avian paramyxovirus that causes significant economic losses to the poultry industry worldwide, with variations in NDV pathogenicity due to the differences in virulence between strains. However, there is limited knowledge regarding the avian innate immune response to NDV infection. In this study, transcriptional profiles were obtained from chick embryo fibroblasts (CEFs) that were infected with the highly virulent NDV Herts/33 strain or the nonvirulent LaSota strain using RNA-seq...
March 30, 2018: Viruses
https://www.readbyqxmd.com/read/29599004/pathology-and-distribution-of-velogenic-viscerotropic-newcastle-disease-virus-in-the-reproductive-system-of-vaccinated-and-unvaccinated-laying-hens-gallus-gallus-domesticus-by-immunohistochemical-labelling
#9
A O Igwe, C L Afonso, W S Ezema, C C Brown, J O A Okoye
This study investigated the pathological changes in the reproductive system of laying hens that lead to the poor egg production and quality in Newcastle disease (ND) and the distribution of the virus in the system. Two hundred and forty Isa-Brown pullets were divided randomly into vaccinated and unvaccinated groups (n = 120 each). The vaccinated group was given Hitchner B1 vaccine at 1 day of age, La Sota vaccine at 4 weeks of age and Komarov vaccine at 9 and 16 weeks of age. At the peak of egg production, the laying hens (32 weeks old) were assigned randomly into four groups (n = 60): VC, vaccinated with ND vaccines and inoculated intramuscularly with velogenic viscerotropic ND virus (vvNDV); VU, vaccinated unchallenged; UC, unvaccinated challenged; and UU, unvaccinated unchallenged...
February 2018: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29578068/generation-and-evaluation-of-a-recombinant-newcastle-disease-virus-strain-r2b-with-an-altered-fusion-protein-cleavage-site-as-a-vaccine-candidate
#10
Kalpana Yadav, Dinesh C Pathak, Deep Prakash Saikia, Ashis Debnath, Saravanan Ramakrishnan, Sohini Dey, Madhan Mohan Chellappa
Newcastle disease (ND) is a highly contagious and fatal disease of chickens. Newcastle disease virus (NDV) strain R2B is an Indian mesogenic strain used for secondary vaccination in chickens. Mesogenic strains have increased virulence and immunogenicity but may cause disease in vaccinated birds, thus rendering them ineffective for use. In this study, we generated a recombinant NDV by changing the fusion protein cleavage site of mesogenic rNDV-R2B from a polybasic amino acid motif RRQKRF to a dibasic amino acid motif GRQGRL leading to generation of an attenuated virus, rNDV-R2B-FPCS...
March 22, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29556820/genetic-diversity-of-avian-avulavirus-1-newcastle-disease-virus-genotypes-vig-and-viib-circulating-in-wild-birds-in-kazakhstan
#11
Mukhit B Orynbayev, Sasan Fereidouni, Abylay R Sansyzbai, Bakhytkul A Seidakhmetova, Vitaliy M Strochkov, Askar M Nametov, Sandugash O Sadikaliyeva, Asel Nurgazieva, Kaissar K Tabynov, Nurkuysa M Rametov, Kulyaisan T Sultankulova
In order to improve current understanding of the molecular epidemiology of avian avulavirus 1 (AAvV-1, formerly avian paramyxovirus 1) in wild birds in Kazakhstan, 860 cloacal swab samples were evaluated. Samples were collected from 37 families of wild birds in nine different regions in the years 2011 and 2014. Overall, 54 positive samples (4.2%) were detected from 17 different families of wild birds, and 16 AAvV-1 isolates were characterized. Three of the isolates contained the fusion protein cleavage site motif RRQKR, and 13 contained KRQKR, which is typical for pathogenic strains of AAvV-1...
March 20, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29556508/production-and-purification-of-high-titer-newcastle-disease-virus-for-use-in-preclinical-mouse-models-of-cancer
#12
Lisa A Santry, Thomas M McAusland, Leonardo Susta, Geoffrey A Wood, Pierre P Major, Jim J Petrik, Byram W Bridle, Sarah K Wootton
Newcastle disease virus (NDV) is a single-stranded, negative-sense RNA virus in the Paramyxoviridae family. Although primarily an avian pathogen, NDV is a potent oncolytic virus that has been shown to be safe and effective in a variety of preclinical cancer models and human clinical trials. To produce virus for oncolytic trials, NDV is commonly amplified in embryonated chicken eggs and purified from the allantoic fluid. Conventional methods for purifying virus from allantoic fluid often result in relatively low-titer preparations containing high levels of impurities, including immunogenic chicken host cell proteins from allantoic fluid...
June 15, 2018: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/29540633/virucidal-activity-of-a-quaternary-ammonium-compound-associated-with-calcium-hydroxide-on-avian-influenza-virus-newcastle-disease-virus-and-infectious-bursal-disease-virus
#13
Mariko Ito, Md Shahin Alam, Mayuko Suzuki, Satoru Takahashi, Miyuki Komura, Natthanan Sangsriratakul, Dany Shoham, Kazuaki Takehara
A quaternary ammonium compound (QAC) was evaluated for its virucidal efficacies with food additive grade calcium hydroxide (FdCa(OH)2 ). When the QAC was diluted 1:500 (QACx500) with redistilled water (dW2 ), it inactivated avian influenza virus (AIV) within 30 sec at 25°C, while at 2°C, it required 1 hr for inactivation. When FdCa(OH)2 powder was added to QACx500 at a final concentration of 0.17%, the mixture, namely Mix500, inactivated AIV within 3 min at 2°C. After contamination with 1% fetal bovine serum (FBS), Mix500 inactivated AIV within 2 hr at 2°C, but QACx500 did not...
March 14, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29536316/newcastle-disease-vaccination-in-captive-bred-wild-birds
#14
C W C Gomes, G Funkler, I Andretta, M O Gonçalves, H F Santos, C E F Cruz
The breeding of wild birds in captivity assumes an increasingly important role in conservation due to the loss of species and their habitats. Providing the environmental and nutritional needs of species kept in captivity is the key for achieving success in such initiatives. Among the flock health practices, we highlight here wild bird vaccination, a scarcely studied subject. This study clinically and serologically evaluates the effect of applying a vaccination protocol against Newcastle disease in three groups of ornamental wild birds...
March 14, 2018: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29535762/transcriptional-innate-immune-response-of-the-developing-chicken-embryo-to-newcastle-disease-virus-infection
#15
Megan A Schilling, Robab Katani, Sahar Memari, Meredith Cavanaugh, Joram Buza, Jessica Radzio-Basu, Fulgence N Mpenda, Melissa S Deist, Susan J Lamont, Vivek Kapur
Traditional approaches to assess the immune response of chickens to infection are through animal trials, which are expensive, require enhanced biosecurity, compromise welfare, and are frequently influenced by confounding variables. Since the chicken embryo becomes immunocompetent prior to hatch, we here characterized the transcriptional response of selected innate immune genes to Newcastle disease virus (NDV) infection in chicken embryos at days 10, 14, and 18 of embryonic development. The results suggest that the innate immune response 72 h after challenge of 18-day chicken embryo is both consistent and robust...
2018: Frontiers in Genetics
https://www.readbyqxmd.com/read/29532715/importin-%C3%AE-5-negatively-regulates-importin-%C3%AE-1-mediated-nuclear-import-of-newcastle-disease-virus-matrix-protein-and-viral-replication-and-pathogenicity-in-chicken-fibroblasts
#16
Zhiqiang Duan, Haixu Xu, Xinqin Ji, Jiafu Zhao, Houqiang Xu, Yan Hu, Shanshan Deng, Shunlin Hu, Xiufan Liu
The matrix (M) protein of Newcastle disease virus (NDV) is demonstrated to localize in the nucleus via intrinsic nuclear localization signal (NLS), but cellular proteins involved in the nuclear import of NDV M protein and the role of M's nuclear localization in the replication and pathogenicity of NDV remain unclear. In this study, importin β1 was screened to interact with NDV M protein by yeast two-hybrid screening. This interaction was subsequently confirmed by co-immunoprecipitation and pull-down assays...
March 13, 2018: Virulence
https://www.readbyqxmd.com/read/29532373/effect-of-dietary-phytogenics-herbal-mixture-supplementation-on-growth-performance-nutrient-utilization-antioxidative-properties-and-immune-response-in-broilers
#17
Ahmed A Saleh, Tarek A Ebeid, Alaeldein M Abudabos
This experiment was conducted to study that effect of a phytogenics (herbal mixture) supplementation as alternative to antibiotics on the growth performance and immune response in broilers. Three thousand broiler male chicks at 1 day of age were housed in floor pens and divided into five experimental groups with five replicates of 120 birds each. The first group was fed the basal diet without any additive in feed or water; the second group was fed the basal diet, and the drinking water was supplemented with mixture of antibiotics (Doxycycline 1 g/5 L + Colistine sulfate 1 g/5 L) for the first 10 days of life...
March 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29521098/status-updates-of-newcastle-disease-and-amelioration-effects-of-medicinal-plants-against-newcastle-disease-virus-a-review
#18
A Ashraf, S Mahboob, R Andleeb, M U Ijaz, M S Shah
Recently, medicinal plants are achieving great interest because of their use in ethno medicine treatment of different common diseases and also other medicinal assertions are now reinforced by comprehensive scientific evidence. Almost 82 research articles and abstracts published, so far, were screened for evaluating antiviral efficiency of various plant samples and 23 different plants were found to be traditionally used against Newcastle disease (ND). ND is a most transmissible viral disease of avian species caused by virulent strain of Avula virus from the Paramyxoviridae family...
2018: Acta Virologica
https://www.readbyqxmd.com/read/29519533/a-novel-genotype-vii-newcastle-disease-virus-vaccine-candidate-generated-by-mutation-in-the-l-and-f-genes-confers-improved-protection-in-chickens
#19
Yanhong Ji, Tao Liu, Yingying Du, Xiaole Cui, Qingzhong Yu, Zhengxiang Wang, Jinjin Zhang, Yu Li, Qiyun Zhu
Administration of vaccines combined with the good management and strict biosecurity is an effective way for Newcastle disease (ND) control. However, vaccine failure is continuously reported in some countries mainly because the antigenic difference between the used vaccine and field strains even they are of one serotype. Therefore, development of antigen-matched ND vaccines is needed to improve the vaccine efficacy in birds. In this study, we introduced four site mutations, K1756A, D1881A, K1917A and E1954Q, respectively, into the large protein gene of the virulent genotype VII Newcastle disease virus (NDV) G7 strain using reverse genetics technology...
March 2018: Veterinary Microbiology
https://www.readbyqxmd.com/read/29519506/cleavage-site-of-newcastle-disease-virus-determines-viral-fitness-in-persistent-infection-cells
#20
Haijin Liu, Renata Servan de Almeida, Patricia Gil, Emmanuel Albina
Newcastle disease, caused by infection with virulent strains of Newcastle disease virus (NDV), poses a risk for the poultry industry. The virulence of NDV is mainly determined by the cleavage site of F protein. Lentogenic NDV can become velogenic after passages in SPF chicken brain and air sac based on some strains isolated from water birds, because the proportion of virulent-related strains gradually increases. In contrast, this proportion remains unchanged if NDV is passaged via 10-day-old SPF chicken embryos...
March 2018: Veterinary Microbiology
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