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Newcastle disease virus

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https://www.readbyqxmd.com/read/28220114/roles-of-the-polymerase-associated-protein-genes-in-newcastle-disease-virus-virulence
#1
Xiao-Hui Yu, Jin-Long Cheng, Jia Xue, Ji-Hui Jin, Yang Song, Jing Zhao, Guo-Zhong Zhang
The virulence of Newcastle disease virus varies greatly and is determined by multiple genetic factors. In this study, we systematically evaluated the roles of the polymerase-associated (NP, P and L) protein genes in genotype VII NDV virulence after confirming the envelope-associated (F and HN) proteins contributed greatly to NDV virulence. The results revealed that the polymerase-associated protein genes individually had certain effect on virulence, while transfer of these three genes in combination significantly affected the chimeric virus virulence, especially when the L gene was involved...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28215687/deterioration-of-eggshell-quality-is-related-to-calbindin-in-laying-hens-infected-with-velogenic-genotype-viid-newcastle-disease-virus
#2
Ruiqiao Li, Xuefeng Qi, Xueying Han, Caihong Liu, Jing Wang, Ruichun Wang, Jingyu Wang, Jinhai Huang
The aim of this study was to determine the mechanism by which Newcastle disease virus (NDV) affects eggshell quality. Thirty-week-old specific pathogen free (SPF) egg-laying hens were inoculated with the velogenic genotype VIId NDV strain (infected group) or with inoculating media without virus (control group) by combined intraocular and intranasal routes. The levels of CaBP-D28k mRNA expression in the uterus, a gene related to eggshell quality, were examined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28203287/specific-immunotherapy-in-renal-cancer-a-systematic-review
#3
REVIEW
Armin Hirbod-Mobarakeh, Hesam Addin Gordan, Zahra Zahiri, Mohammad Mirshahvalad, Sima Hosseinverdi, Brian I Rini, Nima Rezaei
BACKGROUND: Renal cell cancer (RCC) is the tenth most common malignancy in adults. In recent years, several approaches of active and passive immunotherapy have been studied extensively in clinical trials of patients with RCC. The aim of this systematic review was to assess the clinical efficacy of various approaches of specific immunotherapy in patients with RCC. METHODS: We searched Medline, Scopus, CENTRAL, TRIP, DART, OpenGrey and ProQuest without any language filter through to 9 October 2015...
February 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28198500/molecular-characterization-expression-and-functional-analysis-of-chicken-traf6
#4
J Jin, J S Ran, C W Yang, X S Jiang, Y G Zhou, Z Q Feng, Y Wang, D Lan, P Ren, Y P Liu
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial adaptor molecule of the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily, which can trigger downstream signaling cascades involved in innate immunity. The function of TRAF6 has been clarified in mammals but is poorly understood in chicken. In our study, we investigated TRAF6 function in birds, particularly in chicken innate immune responses, by cloning and characterizing chicken TRAF6 (chTRAF6). The full-length coding sequence of chTRAF6 comprised 1638 bp and encoded a 545-amino acid protein, which shares high sequence similarity with TRAF6 of other species and consists of four structurally conserved domains...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28194010/intratumoral-modulation-of-the-inducible-co-stimulator-icos-by-recombinant-oncolytic-virus-promotes-systemic-anti-tumour-immunity
#5
Dmitriy Zamarin, Rikke B Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D Wolchok, James P Allison
Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease virus (NDV), in addition to the activation of innate immunity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulator (ICOS) being most notable. To explore ICOS as a direct target in the tumour, we engineered a recombinant NDV-expressing ICOS ligand (NDV-ICOSL)...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28185139/rescue-of-a-recombinant-newcastle-disease-virus-strain-r2b-expressing-green-fluorescent-protein
#6
Madhan Mohan Chellappa, Sohini Dey, Satish Gaikwad, Dinesh C Pathak, Vikram N Vakharia
Newcastle disease virus (NDV), strain R2B is a mesogenic vaccine strain used for booster vaccination in chickens against Newcastle disease in India and many south East Asian countries. A full-length cDNA clone of the virus was generated by ligating eight overlapping fragments generated by reverse transcription polymerase chain reaction having unique restriction enzyme sites within them. This full-length cDNA clone was flanked by hammerhead ribozyme and hepatitis delta virus ribozyme sequences. Defined genetic markers were introduced into the NDV genome to differentiate the rescued virus from the parent virus...
February 9, 2017: Virus Genes
https://www.readbyqxmd.com/read/28183763/full-genomic-characterization-of-a-lentogenic-newcastle-disease-virus-isolated-from-farm-reared-ostriches-struthio-camelus-in-northwest-china
#7
Shanhui Ren, Chongyang Wang, Xiaolong Gao, Xue Zhang, Xiangwei Wang, Yanqing Jia, Yanhong Wang, Xinglong Wang, Zengqi Yang
To our knowledge, our study is the first to report the whole-genome sequence of an ostrich-origin Newcastle disease virus (NDV) isolate, abbreviated as Ostrich/SX-01/06. Phylogenetic analysis revealed that this isolate belongs to the subgenotype c in class II. The identification of the complete genome will provide useful information regarding ostrich diseases, especially NDV.
February 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28183762/complete-genome-sequence-of-a-velogenic-newcastle-disease-virus-strain-isolated-from-a-clinically-healthy-exotic-parakeet-melopsittacus-undulatus-in-pakistan
#8
Abdul Wajid, Asma Basharat, Taseer Ahmed Khan, Muhammad Wasim, Shafqat Fatima Rehmani
The complete genome sequence of a virulent Newcastle disease virus (vNDV) strain isolated from an exotic parakeet (Melopsittacus undulatus) is described here. The virulent strain parakeet/Pak/R-Pindi/SFR-16/2016 was isolated from a bird reared as a pet in the province of Punjab in the northern region of Pakistan in 2016. Phylogenetic analysis classified the isolate as a member of NDV class II, subgenotype VIIi, in genotype VII.
February 9, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28163156/clinicopathological-characterization-of-experimental-infection-in-chickens-with-sub-genotype-viii-newcastle-disease-virus-isolated-from-peafowl
#9
P A Desingu, S D Singh, K Dhama, O R Vinodh Kumar, Y S Malik, R Singh
Newcastle disease (ND) is an economically important viral disease distressing poultry industry across the globe. Herein, we report the clinicopathology of sub-genotype VIIi Newcastle disease virus (NDV) isolated from peafowl in chickens. The virus isolate produced systemic infection with prominent tropism in visceral organs in chicken, confirmed on the basis of gross and microscopic lesions, and immunohistochemistry findings. The experimentally infected chickens exhibited 100% mortality with severe hemorrhagic lesions in the proventriculus and intestine, especially marked lymphocytolysis in spleen and bursa...
February 3, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28135295/correction-identification-of-optimal-insertion-site-in-recombinant-newcastle-disease-virus-rndv-vector-expressing-foreign-gene-to-enhance-its-anti-tumor-effect
#10
Ziye Pan, Jinjiao He, Lubna M Rasoul, Yunye Liu, Ruixiang Che, Yun Ding, Xiaocheng Guo, Jiarui Yang, Dehua Zou, Hua Zhang, Deshan Li, Hongwei Cao
[This corrects the article DOI: 10.1371/journal.pone.0164723.].
2017: PloS One
https://www.readbyqxmd.com/read/28120474/effect-of-black-cumin-seeds-on-growth-performance-nutrient-utilisation-immunity-gut-health-and-nitrogen-excretion-by-broiler-chickens
#11
Pawan Kumar, Amlan Kumar Patra, Guru Prasad Mandal, Indranil Samanta, Saktipada Pradhan
BACKGROUND: Use of antibiotic growth promoters (AB) as feed additives in broiler chickens poses risky due to cross-resistance amongst pathogens and residues in tissues. The study aims to evaluate the supplementation of black cumin seed (BCS) as a natural growth promoter on nutrient utilisation, intestinal microbiota and morphology, immunity, anti-oxidant status, protein deposition in muscles, and nitrogen excretion by chickens. RESULTS: Broiler chickens were fed BCS at 0, 5, 10 and 20 g kg(-1) diet...
January 25, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28116911/co-circulation-of-paramyxo-and-influenza-viruses-in-pigeons-in-egypt
#12
Shimaa M G Mansour, Fakry F Mohamed, Amal A M Eid, Sunil K Mor, Sagar M Goyal
In recent years, avian influenza virus (AIV) and Newcastle disease virus (NDV) have caused large-scale outbreaks in many countries, including Egypt. The culling and vaccination strategies have failed to control both viruses in Egypt. In this study, we investigated the outbreaks of nervous manifestations and deaths in pigeons between 2013 and 2015. The H5N1 subtype of the highly pathogenic avian influenza (HPAI) virus and pigeon paramyxovirus-1 (PPMV-1), an antigenic variant of NDV, were found to be the cause; AIV and PPMV-1 were isolated from 61...
January 24, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28110247/a-novel-chimeric-newcastle-disease-virus-vectored-vaccine-against-highly-pathogenic-avian-influenza-virus
#13
Shin-Hee Kim, Anandan Paldurai, Siba K Samal
Avian influenza (AI) is an economically-important disease of poultry worldwide. The use of vaccines to control AI has increased because of frequent outbreaks of the disease in endemic countries. Newcastle disease virus (NDV) vectored vaccine has shown to be effective in protecting chickens against a highly pathogenic avian influenza virus (HPAIV) infection. However, preexisting antibodies to NDV vector might affect protective efficacy of the vaccine in the field. As an alternative strategy, we evaluated vaccine efficacy of a chimeric NDV vectored vaccine in which the ectodomains of F and HN proteins were replaced by those of avian paramyxovirus serotype-2...
January 19, 2017: Virology
https://www.readbyqxmd.com/read/28061999/newcastle-disease-virus-from-domestic-mink-china-2014
#14
Panpan Zhao, Lingshuang Sun, Xiao Sun, Siwen Li, Wen Zhang, Laura A Pulscher, Hongliang Chai, Mingwei Xing
Newcastle disease virus (NDV) is a pathogen that most often infects poultry species. In investigating a 2014 outbreak of encephalitis and death among farmed mink (Mustela vison), we found pathological and later experimental evidence that NDV can infect and cause severe encephalitic and pneumonic disease in these animals. Our findings confirm the host range of NDV.
January 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28057380/current-and-future-vaccines-and-vaccination-strategies-against-infectious-laryngotracheitis-ilt-respiratory-disease-of-poultry
#15
Maricarmen García
Infectious laryngotracheitis (ILT) is an economically important respiratory disease of poultry that affects the industry worldwide. Vaccination is the principal tool in the control of the disease. Two types of vaccines, live attenuated and recombinant viral vector, are commercially available. The first generation of GaHV-1 vaccines available since the early 1960's are live viruses, attenuated by continuous passages in cell culture or embryos. These vaccines significantly reduce mortalities and, in particular, the chicken embryo origin (CEO) vaccines have shown to limit outbreaks of the disease...
December 24, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/28052812/newcastle-disease-virus-vectored-infectious-laryngotracheitis-vaccines-protect-commercial-broiler-chickens-in-the-presence-of-maternally-derived-antibodies
#16
Qingzhong Yu, Stephen Spatz, Yufeng Li, Jilong Yang, Wei Zhao, Zhenyu Zhang, Guoyuan Wen, Maricarmen Garcia, Laszlo Zsak
Newcastle disease virus (NDV) recombinants expressing the infectious laryngotracheitis virus (ILTV) glycoproteins B and D have previously been demonstrated to confer complete clinical protection against virulent ILTV and NDV challenges in naive chickens. We extended this study to assess whether maternally derived antibody (MDA) against NDV and ILTV would interfere with protection in vaccinated broiler chickens. Chickens with a mean NDV MDA hemagglutination inhibition (HI) titer of 6.4 (log2) and detectable ILTV neutralization (VN) antibodies at hatch were vaccinated with rLS/ILTV-gB or rLS/ILTV-gD at 1 or 10day of age (DOA) or on both days...
February 1, 2017: Vaccine
https://www.readbyqxmd.com/read/28043009/re-evaluation-the-immune-efficacy-of-newcastle-disease-virus-vaccine-in-commercial-laying-chickens
#17
Qingsong Han, Xiaolong Gao, Pengpeng Wu, Sa Xiao, Xinglong Wang, Peng Liu, Lina Tong, Huafang Hao, Shuxia Zhang, Ruyi Dang, Zengqi Yang
Newcastle disease virus (NDV) infection causes serious problems in laying chickens, like reducing egg production, increasing rate of abnormal eggs in spite of strict vaccination in layer farms program. A new evaluation system is needed to show complete protection of the immunization in laying chickens based on the egg-laying performance, rather than clinical signs of the disease. In this study, laying chickens with different anti-NDV HI (hemagglutination-inhibition) antibody titer after vaccination were divided into different groups...
December 20, 2016: Research in Veterinary Science
https://www.readbyqxmd.com/read/28035479/evidence-of-independent-evolution-of-genotype-xiii-newcastle-disease-viruses-in-india
#18
Moushumee Das, Sachin Kumar
Despite the prevalence of Newcastle disease virus (NDV) outbreaks in India through the decades, there has been little genetic characterisation of the virulent strains circulating in Northeast India. In 2014, a poultry farm in the Kamrup district of Assam reported an ND outbreak. In this study, genetic analysis and clinicopathological tests showed the virulent nature of the isolate Kamrup. Based on prudent classification criteria, the virulent strain Kamrup was found to be most closely related to members of genotype XIII of class II NDV...
December 29, 2016: Archives of Virology
https://www.readbyqxmd.com/read/28034854/genome-sequence-of-a-virulent-genotype-iii-newcastle-disease-virus-isolated-from-laying-ducks-in-china
#19
Guoyuan Wen, Min Wang, Honglin Wang, Lintao Li, Qingping Luo, Tengfei Zhang, Guofu Cheng, Huabin Shao
Here, we report the complete genome sequence of a virulent Newcastle disease virus (NDV) strain HN1007, isolated from diseased duck flocks in Henan, China, in 2010. The isolate has a genome length of 15,186 nucleotides, and was classified as a member of genotype III of class II.
December 29, 2016: Genome Announcements
https://www.readbyqxmd.com/read/28024856/newcastle-disease-vaccines-a-solved-problem-or-a-continuous-challenge
#20
Kiril M Dimitrov, Claudio L Afonso, Qingzhong Yu, Patti J Miller
Newcastle disease (ND) has been defined by the World Organisation for Animal Health as infection of poultry with virulent strains of Newcastle disease virus (NDV). Lesions affecting the neurological, gastrointestinal, respiratory, and reproductive systems are most often observed. The control of ND must include strict biosecurity that prevents virulent NDV from contacting poultry, and also proper administration of efficacious vaccines. When administered correctly to healthy birds, ND vaccines formulated with NDV of low virulence or viral-vectored vaccines that express the NDV fusion protein are able to prevent clinical disease and mortality in chickens upon infection with virulent NDV...
December 16, 2016: Veterinary Microbiology
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