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https://www.readbyqxmd.com/read/29445265/new-frontiers-in-oncolytic-viruses-optimizing-and-selecting-for-virus-strains-with-improved-efficacy
#1
REVIEW
Kenneth Lundstrom
Oncolytic viruses have demonstrated selective replication and killing of tumor cells. Different types of oncolytic viruses - adenoviruses, alphaviruses, herpes simplex viruses, Newcastle disease viruses, rhabdoviruses, Coxsackie viruses, and vaccinia viruses - have been applied as either naturally occurring or engineered vectors. Numerous studies in animal-tumor models have demonstrated substantial tumor regression and prolonged survival rates. Moreover, clinical trials have confirmed good safety profiles and therapeutic efficacy for oncolytic viruses...
2018: Biologics: Targets & Therapy
https://www.readbyqxmd.com/read/29438228/antitumor-effect-of-the-newcastle-disease-viral-hemagglutinin-neuraminidase-gene-is-expressed-through-an-oncolytic-adenovirus-effect-in-osteosarcoma-cells
#2
Shuang Chen, Qinggao Zhang, Duo Xu, Yiquan Li, Yuanyuan Fan, Wenjie Li, Xunzhe Yin, Yang Zhang, Jingwei Liu, Xiao Li, Lili Sun, Ningyi Jin
Newcastle disease virus (NDV) can specifically kill cancer cells and has less toxicity to normal cells. The hemagglutinin-neuraminidase (HN) protein is an important structural protein in NDV pathogenesis and has been postulated as a promising candidate for antitumor therapy. The aim of this study was to investigate the anticancer potential of recombinant adenovirus Ad-HN-PEG3p-E1a. An MTS assay was performed to determine viral proliferation after viral infection, the data showed that the proliferation ability of osteosarcoma cells decreased, whereas there was no significant change in normal hepatic cells...
March 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29434116/bactericidal-and-virucidal-efficacies-of-potassium-monopersulfate-and-its-application-for-inactivating-avian-influenza-virus-on-virus-spiked-clothes
#3
Sorawot Sonthipet, Sakchai Ruenphet, Kazuaki Takehara
An acidic agent, potassium monopersulfate (PMPS), was evaluated for bactericidal and virucidal effects against Salmonella Infantis (SI), Escherichia coli, rifampicin-resistant Salmonella Infantis (SI-rif), Newcastle disease virus (NDV), and avian influenza virus (AIV), in the absence or presence of organic materials. In addition, inactivation activity toward a virus on virus-spiked clothes was also examined. PMPS could inactivate SI, E. coli, and SI-rif even in the presence of organic materials under various concentrations and exposure/contact time conditions...
February 12, 2018: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/29399179/antitumor-and-immunostimulatory-activities-of-a-genotype-v-recombinant-attenuated-veterinary-newcastle-disease-virus-vaccine
#4
Oscar Antonio Ortega-Rivera, J Luis Quintanar, Susana Del Toro-Arreola, Ángel G Alpuche-Solis, Mayra J Esparza-Araiza, Eva Salinas
Antitumor conventional treatments including chemo/radiotherapy result in several side effects and non-specificity. Therapies including the use of oncolytic viruses, particularly the Newcastle disease virus (NDV), have emerged as an attractive alternative due to their capacity to kill cancer cells directly or through stimulation of the immune system. In the present study, a commercial vaccine composed of a recombinant attenuated NDV strain P05 (rNDV-P05) was assessed for antitumor and immunostimulatory activity...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29397456/immune-responses-of-mature-chicken-bone-marrow-derived-dendritic-cells-infected-with-newcastle-disease-virus-strains-with-differing-pathogenicity
#5
Bin Xiang, Wenxian Zhu, Yaling Li, Pei Gao, Jianpeng Liang, Di Liu, Chan Ding, Ming Liao, Yinfeng Kang, Tao Ren
Infection of chickens with virulent Newcastle disease virus (NDV) is associated with severe pathology and increased morbidity and mortality. The innate immune response contributes to the pathogenicity of NDV. As professional antigen-presenting cells, dendritic cells (DCs) play a unique role in innate immunity. However, the contribution of DCs to NDV infection has not been investigated in chickens. In this study, we selected two representative NDV strains, i.e., the velogenic NDV strain Chicken/Guangdong/GM/2014 (GM) and the lentogenic NDV strain La Sota, to investigate whether NDVs could infect LPS-activated chicken bone-derived marrow DCs (mature chicken BM-DCs)...
February 3, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29373488/a-review-of-eight-high-priority-economically-important-viral-pathogens-of-poultry-within-the-caribbean-region
#6
REVIEW
Arianne Brown Jordan, Victor Gongora, Dane Hartley, Christopher Oura
Viral pathogens cause devastating economic losses in poultry industries worldwide. The Caribbean region, which boasts some of the highest rates of poultry consumption in the world, is no exception. This review summarizes evidence for the circulation and spread of eight high-priority, economically important poultry viruses across the Caribbean region. Avian influenza virus (AIV), infectious bronchitis virus (IBV), Newcastle disease virus (NDV), infectious laryngotracheitis virus (ILTV), avian metapneumovirus (aMPV), infectious bursal disease virus (IBDV), fowl adenovirus group 1 (FADV Gp1), and egg drop syndrome virus (EDSV) were selected for review...
January 26, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29361703/detection-of-antibodies-to-seven-priority-pathogens-in-backyard-poultry-in-trinidad-west-indies
#7
Arianne Brown Jordan, Pompei Bolfa, Silvia Marchi, Shakera Hemmings, Tashard Major, Rod Suepaul, Lemar Blake, Christopher Oura
Backyard poultry farms in Trinidad and Tobago (T&T) play a vital role in providing food and income for rural communities. There is currently no information on the presence and circulation of pathogens in backyard poultry farms in T&T, and little is known in relation to the potential risks of spread of these pathogens to the commercial poultry sector. In order to address this, serum samples were collected from 41 chickens on five backyard farms taken from selected locations in Trinidad. Samples were tested for antibodies to seven priority pathogens of poultry by enzyme-linked immunosorbent assay (ELISA)...
January 20, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29352240/transcriptome-analysis-in-spleen-reveals-differential-regulation-of-response-to-newcastle-disease-virus-in-two-chicken-lines
#8
Jibin Zhang, Michael G Kaiser, Melissa S Deist, Rodrigo A Gallardo, David A Bunn, Terra R Kelly, Jack C M Dekkers, Huaijun Zhou, Susan J Lamont
Enhancing genetic resistance of chickens to Newcastle Disease Virus (NDV) provides a promising way to improve poultry health, and to alleviate poverty and food insecurity in developing countries. In this study, two inbred chicken lines with different responses to NDV, Fayoumi and Leghorn, were challenged with LaSota NDV strain at 21 days of age. Through transcriptome analysis, gene expression in spleen at 2 and 6 days post-inoculation was compared between NDV-infected and control groups, as well as between chicken lines...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330815/supplementing-dietary-rosemary-rosmarinus-officinalis-l-powder-and-vitamin-e-in-broiler-chickens-evaluation-of-humoral-immune-response-lymphoid-organs-and-blood-proteins
#9
Hossein Rostami, Alireza Seidavi, Mohammad Dadashbeiki, Yadollah Asadpour, João Simões, Assar Ali Shah, Vito Laudadio, Caterina Losacco, Antonella Perillo, Vincenzo Tufarelli
The aim of the present study was to evaluate the effect rosemary (Rosmarinus officinalis L.) powder (RP) and vitamin E (VE) at different levels on humoral immunity of broilers during a 42-day production cycle. A total of 270 1-day-old male chicks were assigned to nine groups with three replicates of ten birds each, and diets were supplemented with 0, 0.5, or 1.0% RP and 0, 100, or 200 mg/kg VE, respectively. Commercial-inactivated vaccines against avian influenza (AI) and Newcastle disease (ND) viruses, and living infectious bronchitis virus (IBV) vaccine were administered by spray method...
January 12, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29329546/whole-genome-sequencing-of-genotype-vi-newcastle-disease-viruses-from-formalin-fixed-paraffin-embedded-tissues-from-wild-pigeons-reveals-continuous-evolution-and-previously-unrecognized-genetic-diversity-in-the-u-s
#10
Ying He, Tonya L Taylor, Kiril M Dimitrov, Salman L Butt, James B Stanton, Iryna V Goraichuk, Heather Fenton, Rebecca Poulson, Jian Zhang, Corrie C Brown, Hon S Ip, Marcos Isidoro-Ayza, Claudio L Afonso
BACKGROUND: Newcastle disease viruses (NDV) are highly contagious and cause disease in both wild birds and poultry. A pigeon-adapted variant of genotype VI NDV, often termed pigeon paramyxovirus 1, is commonly isolated from columbids in the United States and worldwide. Complete genomic characterization of these genotype VI viruses circulating in wild columbids in the United States is limited, and due to the genetic variability of the virus, failure of rapid diagnostic detection has been reported...
January 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29325564/engineered-recombinant-protein-products-of-the-avian-paramyxovirus-type-1-nucleocapsid-and-phosphoprotein-genes-for-serological-diagnosis
#11
Na Zhao, Christian Grund, Martin Beer, Timm C Harder
BACKGROUND: Virulent Newcastle disease virus (NDV, avian Avulavirus-1, APMV-1) induces a highly contagious and lethal systemic disease in gallinaceous poultry. APMV-1 antibody detection is used for surveillance and to control vaccination, but is hampered by cross-reactivity to other subtypes of avian Avulaviruses. Data are lacking concerning the applicability of NDV V proteins as differential diagnostic marker to distinguish vaccinated from virus-infected birds (DIVA strategy). METHODS: Full length and C-terminally truncated nucleocapsid (NP) protein, and the unique C-terminal regions of the phospho- (P) and V proteins of the NDV LaSota strain were bacterially expressed as fusion proteins with the multimerization domain of the human C4 binding protein, and used as diagnostic antigens in indirect ELISA...
January 11, 2018: Virology Journal
https://www.readbyqxmd.com/read/29291221/evaluating-the-efficacy-of-lasota-vaccination-induced-protection-in-chickens-upon-challenge-with-a-genotype-iv-strain-of-newcastle-disease-virus
#12
S Bhuvaneswari, K G Tirumurugaan, P Venkatesan, P Manesh Kumar, K Kumanan
Newcastle disease (ND) is a major risk to the poultry industry which results in severe economic loss throughout the world even with vaccination. The vaccine viruses that are used in many countries include the LaSota and other live viruses that were isolated in the early and late 1950s. Reports from several laboratories including ours indicate a greater variance of the circulating strains and recent classification indicates the existence of XVIII different genotypes of NDV strains. The efficiency of the LaSota vaccination in inducing protective immunity to different heterologous strains has been a question and its efficacy upon exposure to a virulent genotype IV strain has not been reported after 1989 world-wide except for India...
September 2017: Virusdisease
https://www.readbyqxmd.com/read/29290303/serological-evidence-for-eight-globally-important-poultry-viruses-in-trinidad-tobago
#13
Arianne Brown Jordan, Jamie Sookhoo, Lemar Blake, Paul Crooks, Zul Mohammed, Judy Molawatti-Bisnath, Christine V F Carrington, Christopher A L Oura
Viruses affecting poultry cause significant levels of disease leading to severe economic losses among poultry farmers worldwide. The Americas region continues to be vulnerable to the spread of poultry viruses across the continents and Caribbean island chains. In Trinidad and Tobago (T&T) there is limited information on the viruses circulating in poultry. Many flock are vulnerable to infection and there are occasional outbreaks of disease resulting in high levels of morbidity and mortality. This study aims to identify important viruses of poultry circulating in T&T through a broad-based surveillance approach...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29281979/resistant-and-susceptible-chicken-lines-show-distinctive-responses-to-newcastle-disease-virus-infection-in-the-lung-transcriptome
#14
Melissa S Deist, Rodrigo A Gallardo, David A Bunn, Jack C M Dekkers, Huaijun Zhou, Susan J Lamont
BACKGROUND: Newcastle disease virus (NDV) is a threat to poultry production worldwide. A better understanding of mechanisms of resistance and susceptibility to this virus will improve measures for NDV prevention and control. Males and females from resistant Fayoumi and susceptible Leghorn lines were either challenged with a lentogenic strain of the virus or given a mock infection at 3 weeks of age. The lung transcriptomes generated by RNA-seq were studied using contrasts across the challenged and nonchallenged birds, the two lines, and three time points post-infection, and by using Weighted Gene Co-expression Network Analysis (WGNCA)...
December 28, 2017: BMC Genomics
https://www.readbyqxmd.com/read/29261447/serologic-surveillance-of-wild-and-pen-reared-ring-necked-pheasants-phasianus-colchicus-as-a-method-of-understanding-disease-reservoirs
#15
Ian A Dwight, Peter S Coates, Simone T Stoute, C Gabriel Senties-Cue, Radhika V Gharpure, Maurice E Pitesky
We investigated exposure to infectious diseases in wild ( n=33) and pen-reared ( n=12) Ring-necked Pheasants ( Phasianus colchicus) in the Central Valley of California during 2014 and 2015. Serologic tests were positive for antibodies against hemorrhagic enteritis (HE), infectious bursal disease (IBD), and Newcastle disease (ND) viruses in both wild and pen-reared pheasants.
December 20, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/29234115/the-glutamic-residue-at-position-402-in-the-c-terminus-of-newcastle-disease-virus-nucleoprotein-is-critical-for-the-virus
#16
Xiaohui Yu, Jinlong Cheng, Zirong He, Chuang Li, Yang Song, Jia Xue, Huiming Yang, Rui Zhang, Guozhong Zhang
The nucleocapsid proteins (NPs) of Newcastle disease virus (NDV) and other paramyxoviruses play an important functional role during genomic RNA replication. Our previous study showed that the NP-encoding gene significantly influenced viral replication. Here, we investigated the roles of certain amino acid residues in the NP C-terminus in viral replication and virulence. Results showed that the glutamic acid residue at position 402 (E402) in the C-terminus of the NP is critical for RNA synthesis in the NDV mini-genome system...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29231283/new-potent-inhibitors-against-newcastle-disease-virus-haemagglutinin-neuraminidase
#17
Paola Rota, Paolo La Rocca, Marco Piccoli, Marco Montefiori, Federica Cirillo, Lars Olsen, Marica Orioli, Pietro Allevi, Luigi Anastasia
Neuraminidase activity is essential for the infection and propagation of Paramyxoviruses, including human parainfluenza viruses (hPIVs) and the Newcastle Disease Virus (NDV). Thus, many inhibitors have been developed based on the 2-deoxy-2,3-didehydro-D-N-acetylneuraminic acid inhibitor (DANA) backbone. Along this line, we report here a series of neuraminidase inhibitors, having C-4 (ptoluensulfonamide and azido substituents) and C-5 (N-perfluorinated chains) modifications to the DANA backbone, that resulted 5- to 15-folds more potent than the current most active compound, the Ntrifluoroacetyl derivative of DANA (FANA), on the NDV haemagglutinin-neuraminidase (NDV-HN)...
December 12, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29228598/analysis-of-molecular-evolution-of-nucleocapsid-protein-in-newcastle-disease-virus
#18
Wentao Fan, Yuliang Xu, Pu Zhang, Peng Chen, Yiran Zhu, Ziqiang Cheng, Xiaona Zhao, Yongxia Liu, Jianzhu Liu
The present study investigated the molecular evolution of nucleocapsid protein (NP) in different Newcastle disease virus (NDV) genotypes. The evolutionary timescale and rate were estimated using the Bayesian Markov chain Monte Carlo (MCMC) method. The p-distance, Bayesian skyline plot (BSP), and positively selected sites were also analyzed. The MCMC tree indicated that NDV diverged about 250 years ago with a rapid evolution rate (1.059 × 10-2 substitutions/site/year) and that different NDV genotypes formed three lineages...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29224228/newcastle-disease-virus-co-expressing-interleukin-7-and-interleukin-15-modified-tumor-cells-as-a-vaccine-for-cancer-immunotherapy
#19
Xiaojing Xu, Qing Sun, Yu Mei, Yonghao Liu, Lixiang Zhao
Interleukin 15 (IL15) and IL7 are two cytokines essential for T cell development and homeostasis. In order to improve the antitumor activity by Newcastle disease virus (NDV)-modified tumor vaccine, we generated a recombinant NDV co-expressing IL15 and IL7 (LX/IL(15+7)) through incorporation of a 2A self-processing peptide into IL15 and IL7 using reverse genetics. B16 cells infected with LX/IL(15+7) expressed both IL15 and IL7 stably. The cytotoxicity assay showed that murine melanoma cells modified with LX/IL(15+7) could significantly enhance the antitumor immune response in vitro...
December 10, 2017: Cancer Science
https://www.readbyqxmd.com/read/29223788/a-multiplex-real-time-rt-pcr-for-simultaneous-detection-of-four-most-common-avian-respiratory-viruses
#20
Nacira Laamiri, Rim Aouini, Boutheina Marnissi, Abdeljelil Ghram, Issam Hmila
A one-step multiplex real-time reverse transcription-PCR (rRT-PCR) assay was developed for simultaneous detection and quantification of four avian respiratory viruses: avian influenza virus (AIV), infectious bronchitis virus (IBV), Newcastle disease virus (NDV) and infectious laryngotracheitis virus (ILTV). In comparison with the singleplex rRT-PCR, the specificity, the sensitivity and the reproducibility of the new assay were evaluated and validated using 70 clinical samples. The optimal cutoff point, the corresponding limit of quantification (LoQ) and the limit of detection (LoD) were statistical established based on receiver operating characteristic (ROC) curve analysis...
December 7, 2017: Virology
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