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Newcastle disease virus

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https://www.readbyqxmd.com/read/28326624/current-status-of-clinical-trials-assessing-oncolytic-virus-therapy-for-urological-cancers
#1
REVIEW
Satoru Taguchi, Hiroshi Fukuhara, Yukio Homma, Tomoki Todo
Oncolytic virus therapy has recently been recognized as a promising new option for cancer treatment. Oncolytic viruses replicate selectively in cancer cells, thus killing them without harming normal cells. Notably, T-VEC (talimogene laherparepvec, formerly called OncoVEX(GM)(-)(CSF) ), an oncolytic herpes simplex virus type 1, was approved by the US Food and Drug Administration for the treatment of inoperable melanoma in October 2015, and was subsequently approved in Europe and Australia in 2016. The efficacies of many types of oncolytic viruses against urological cancers have been investigated in preclinical studies during the past decade, and some have already been tested in clinical trials...
March 21, 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/28316014/rescue-of-recombinant-newcastle-disease-virus-a-short-history-of-how-it-all-started
#2
REVIEW
Aidin Molouki, Ben Peeters
Reverse genetics of viruses has come a long way, and many recombinant viruses have been generated since the first successful "rescues" were reported in the late 1970s. Recombinant Newcastle disease virus (rNDV), a non-segmented negative-sense RNA virus (NSNSV), was first rescued in 1999 using a reverse genetics approach similar to that reported for other recombinant viruses of the order Mononegavirales a few years before. The route from an original NDV isolate to the generation of its recombinant counterpart requires many steps that have to be sequentially and carefully completed...
March 18, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28303720/primary-newcastle-disease-vaccination-of-broilers-comparison-of-the-antibody-seroresponse-and-adverse-vaccinal-reaction-after-eye-nose-drop-or-coarse-spray-application-and-implication-of-the-results-for-a-previously-developed-coarse-dry-powder-vaccine
#3
W J M Landman, C Vervaet, J P Remon, K Huyge, J H H van Eck
To compare antibody seroresponse and adverse vaccinal reaction induced by Newcastle disease (ND) vaccination after eye-nose drop or coarse spray, groups of SPF broiler hens were vaccinated at day 4 (day of hatch is day 0) and intratracheally inoculated with Escherichia coli at day 11. Body weight gain (BWG) was assessed between day 4 and day 18; colibacillosis lesions and serum antibodies were determined at day 18. Meaningful comparison requires similar vaccine uptake. Vaccine virus loss during spray relative to eye-nose drop, which was assessed by comparing the results of endpoint titrations, was 3 log10...
March 17, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28302119/efficacy-of-an-inactivated-bivalent-vaccine-against-the-prevalent-strains-of-newcastle-disease-and-h9n2-avian-influenza
#4
Jing Zhao, Huiming Yang, Hongjun Xu, Zengbin Ma, Guozhong Zhang
BACKGROUND: Newcastle disease (ND) and avian influenza subtype H9N2 (H9N2 AI) are two of the most important diseases of poultry, causing severe economic losses in the global poultry industry. Vaccination is an effective way to prevent and control the spread of ND virus (NDV) and H9N2 AI virus (AIV), but the antigenic differences between the current circulating strains and the vaccine strains might account for recent ND and H9N2 AI outbreaks in vaccinated poultry flocks. METHODS: We developed an inactivated bivalent H9N2 and NDV vaccine based on the current prevalent strains of H9N2 AIV and NDV in China and evaluated its efficacy in chickens in this study...
March 16, 2017: Virology Journal
https://www.readbyqxmd.com/read/28301239/pathotyping-and-phylogenetic-characterization-of-newcastle-disease-viruses-isolated-in-peru-defining-two-novel-subgenotypes-within-genotype-xii
#5
Ana Chumbe, Ray Izquierdo-Lara, Luis Tataje, Rosa Gonzalez, Giovana Cribillero, Armando E González, Manolo Fernández-Díaz, Eliana Icochea
Infections of poultry with virulent strains of avian paramyxovirus 1 (APMV-1), also known as Newcastle disease viruses (NDVs), cause Newcastle disease (ND). This highly contagious disease affects poultry and many other species of birds worldwide. In countries where the disease is prevalent, constant monitoring and characterization of isolates causing outbreaks are necessary. In this study, we report the results of pathogenicity testing and phylogenetic analyses of seven NDVs isolated from several regions of Peru between 2004 and 2015...
March 2017: Avian Diseases
https://www.readbyqxmd.com/read/28293547/proinflammatory-response-induced-by-newcastle-disease-virus-in-tumor-and-normal-cells
#6
Teridah Ernala Ginting, Jeremiah Suryatenggara, Salomo Christian, George Mathew
PURPOSE: To investigate the specific role of immune responses induced by lentogenic Newcastle disease virus (NDV) for its antitumor effect. MATERIALS AND METHODS: NDV LaSota strain was used to infect the following human cells: non-small cell lung carcinoma (A549), glioblastoma (U87MG and T98G), mammary gland adenocarcinoma (MCF7 and MDA-MB-453), hepatocellular carcinoma (Huh7), transformed embryonic kidney cells (HEK293), primary monocytes, lung fibroblast (HF19), skin fibroblast (NB1RGB) and rat astroglia (RCR-1) at 0...
2017: Oncolytic Virotherapy
https://www.readbyqxmd.com/read/28290220/specific-antibody-mediated-immunity-in-the-reproductive-tract-of-laying-chickens-immunized-against-newcastle-disease-with-conventional-attenuated-and-inactivated-vaccines
#7
F Rauw, T G Nguyen, E Ngabirano, S Marché, B Lambrecht
Despite the widespread and successful use of Newcastle disease (ND) vaccines, Newcastle disease virus (NDV) can seriously injure the reproductive tract of egg-laying hens, leading to rapid egg-drop and poor shell quality. Few published studies investigated local NDV-specific immune response in the reproductive tract after ND-vaccination of hens. The present study investigated, for the first time, local NDV-specific antibody-mediated immunity in segments of the oviduct during the laying period. Specific pathogen-free (SPF) White Leghorn chickens were immunized following a ND vaccination program applied in the field, which combined ND-attenuated vaccine (inoculated subcutaneously at one day, 2 weeks and 11 weeks of age) with inactivated vaccine (inoculated intramuscularly at 17 weeks)...
March 14, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28286234/cellular-protein-gltscr2-a-valuable-target-for-the-development-of-broad-spectrum-antivirals
#8
Cui-Cui Li, Hui-Jun Dong, Peng Wang, Wen Meng, Xiao-Jing Chi, Shi-Chong Han, Shuo Ning, Chuang Wang, Xiao-Jia Wang
Viral infection induces translocation of the nucleolar protein GLTSCR2 from the nucleus to the cytoplasm, resulting in attenuation of the type I interferon IFN-β. Addressing the role of GLTSCR2 in viral replication, we detect that knocking down GLTSCR2 by shRNAs results in significant suppression of viral replication in mammalian and chicken cells. Injection of chicken embryo with the GLTSCR2-specific shRNA-1370 simultaneously or 24 h prior to infection with Newcastle disease virus (NDV) substantially reduces viral replication in chicken embryo fibroblasts...
March 7, 2017: Antiviral Research
https://www.readbyqxmd.com/read/28286036/rescue-of-nonlytic-newcastle-disease-virus-ndv-expressing-il-15-for-cancer-immunotherapy
#9
Xiaojing Xu, Qing Sun, Xiao Yu, Lixiang Zhao
In order to test and enhance the antitumor activity against mice melanoma by NDV-modified tumor vaccine, a recombinant NDV expressing IL-15 (LX/(IL-15)) was generated by reverse genetics. Then, the expression level and biological activity of IL-15 were examined. Our results showed that mice tumor cell lines infected with LX/(IL-15) expressed IL-15 at a high level, and that expressed IL-15 was biologically active. Expression kinetics demonstrated that the highest expression level of IL-15 was at 48h post infection...
March 7, 2017: Virus Research
https://www.readbyqxmd.com/read/28277778/herd-immunity-to-newcastle-disease-virus-in-broiler-flocks-in-israel
#10
Anat Wiseman, Elyakum M Berman
Due to the ongoing need to protect poultry from virulent Newcastle disease virus, all commercial poultry flocks in Israel are vaccinated according to a defined program using a combination of live and inactivated vaccines. The vaccination protocol for broilers during the years of the study comprised a live vaccine administered by spray on the day of hatch, inactivated vaccine by subcutaneous injection at 10-12 days of age, and another live vaccine given by aerosol at 17-21 days of age. A cross-sectional study was designed in order to examine the influence of herd immunity on the risk of Newcastle disease (ND) outbreak in broiler flocks...
March 1, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28277776/immunogenicity-and-protection-efficacy-evaluation-of-avian-paramyxovirus-serotype-1-apmv-1-isolates-in-experimentally-infected-chicken
#11
John Bosco Omony, Agnes Wanyana, Halid Kirunda, Kizito K Mugimba, Jessica Lukanga Nakavuma, Otim-Onapa Maxwell, Denis Karuhize Byarugaba
Vaccine failures against Newcastle disease vaccinated with the current commercial vaccines have been reported which are associated with many factors, including genotypic and antigenic differences between vaccine isolates and outbreaks strains, although all APMV-1 members belong to one serotype. We assessed the immunoprotection ability of four thermostable, low-virulent ND-virus isolates from Ugandan waterfowl against challenge with a virulent strain (MDT = 36.8h, ICPI = 1.78) isolated from morbid chicken. Six-week-old commercial Leghorn layers, challenged at 21 days post immunization (dpi) were used...
March 2, 2017: Avian Pathology: Journal of the W.V.P.A
https://www.readbyqxmd.com/read/28246027/recombinant-newcastle-disease-virus-expressing-human-trail-as-a-potential-candidate-for-hepatoma-therapy
#12
Yunzhou Wu, Jinjiao He, Jingshu Geng, Ying An, Xianlong Ye, Shijun Yan, Qingzhong Yu, Jiechao Yin, Zhenyu Zhang, Deshan Li
Newcastle disease virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently proved for clinical trials. We have previously reported, for the first time, NDV Anhinga strain has an efficient cancer therapeutic efficacy in hepatoma. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the potential use of recombinant soluble TRAIL as a cancer therapeutic agent...
February 27, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28241773/zika-virus-infection-in-pregnancy-a-systematic-review-of-disease-course-and-complications
#13
REVIEW
Ezinne C Chibueze, Veronika Tirado, Katharina da Silva Lopes, Olukunmi O Balogun, Yo Takemoto, Toshiyuki Swa, Amarjargal Dagvadorj, Chie Nagata, Naho Morisaki, Clara Menendez, Erika Ota, Rintaro Mori, Olufemi T Oladapo
OBJECTIVES: To characterize maternal Zika virus (ZIKV) infection and complement the evidence base for the WHO interim guidance on pregnancy management in the context of ZIKV infection. METHODS: We searched the relevant database from inception until March 2016. Two review authors independently screened and assessed full texts of eligible reports and extracted data from relevant studies. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS) and the National Institute of Health (NIH) tool for observational studies and case series/reports, respectively...
February 28, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28220114/roles-of-the-polymerase-associated-protein-genes-in-newcastle-disease-virus-virulence
#14
Xiao-Hui Yu, Jin-Long Cheng, Jia Xue, Ji-Hui Jin, Yang Song, Jing Zhao, Guo-Zhong Zhang
The virulence of Newcastle disease virus varies greatly and is determined by multiple genetic factors. In this study, we systematically evaluated the roles of the polymerase-associated (NP, P and L) protein genes in genotype VII NDV virulence after confirming the envelope-associated (F and HN) proteins contributed greatly to NDV virulence. The results revealed that the polymerase-associated protein genes individually had certain effect on virulence, while transfer of these three genes in combination significantly affected the chimeric virus virulence, especially when the L gene was involved...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28215687/deterioration-of-eggshell-quality-is-related-to-calbindin-in-laying-hens-infected-with-velogenic-genotype-viid-newcastle-disease-virus
#15
Ruiqiao Li, Xuefeng Qi, Xueying Han, Caihong Liu, Jing Wang, Ruichun Wang, Jingyu Wang, Jinhai Huang
The aim of this study was to determine the mechanism by which Newcastle disease virus (NDV) affects eggshell quality. Thirty-week-old specific pathogen free (SPF) egg-laying hens were inoculated with the velogenic genotype VIId NDV strain (infected group) or with inoculating media without virus (control group) by combined intraocular and intranasal routes. The levels of CaBP-D28k mRNA expression in the uterus, a gene related to eggshell quality, were examined by quantitative reverse transcriptase polymerase chain reaction (RT-PCR)...
March 15, 2017: Theriogenology
https://www.readbyqxmd.com/read/28203287/specific-immunotherapy-in-renal-cancer-a-systematic-review
#16
REVIEW
Armin Hirbod-Mobarakeh, Hesam Addin Gordan, Zahra Zahiri, Mohammad Mirshahvalad, Sima Hosseinverdi, Brian I Rini, Nima Rezaei
BACKGROUND: Renal cell cancer (RCC) is the tenth most common malignancy in adults. In recent years, several approaches of active and passive immunotherapy have been studied extensively in clinical trials of patients with RCC. The aim of this systematic review was to assess the clinical efficacy of various approaches of specific immunotherapy in patients with RCC. METHODS: We searched Medline, Scopus, CENTRAL, TRIP, DART, OpenGrey and ProQuest without any language filter through to 9 October 2015...
February 2017: Therapeutic Advances in Urology
https://www.readbyqxmd.com/read/28198500/molecular-characterization-expression-and-functional-analysis-of-chicken-traf6
#17
J Jin, J S Ran, C W Yang, X S Jiang, Y G Zhou, Z Q Feng, Y Wang, D Lan, P Ren, Y P Liu
Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial adaptor molecule of the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily, which can trigger downstream signaling cascades involved in innate immunity. The function of TRAF6 has been clarified in mammals but is poorly understood in chicken. In our study, we investigated TRAF6 function in birds, particularly in chicken innate immune responses, by cloning and characterizing chicken TRAF6 (chTRAF6). The full-length coding sequence of chTRAF6 comprised 1638 bp and encoded a 545-amino acid protein, which shares high sequence similarity with TRAF6 of other species and consists of four structurally conserved domains...
February 8, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28194010/intratumoral-modulation-of-the-inducible-co-stimulator-icos-by-recombinant-oncolytic-virus-promotes-systemic-anti-tumour-immunity
#18
Dmitriy Zamarin, Rikke B Holmgaard, Jacob Ricca, Tamar Plitt, Peter Palese, Padmanee Sharma, Taha Merghoub, Jedd D Wolchok, James P Allison
Emerging data suggest that locoregional cancer therapeutic approaches with oncolytic viruses can lead to systemic anti-tumour immunity, although the appropriate targets for intratumoral immunomodulation using this strategy are not known. Here we find that intratumoral therapy with Newcastle disease virus (NDV), in addition to the activation of innate immunity, upregulates the expression of T-cell co-stimulatory receptors, with the inducible co-stimulator (ICOS) being most notable. To explore ICOS as a direct target in the tumour, we engineered a recombinant NDV-expressing ICOS ligand (NDV-ICOSL)...
February 13, 2017: Nature Communications
https://www.readbyqxmd.com/read/28185139/rescue-of-a-recombinant-newcastle-disease-virus-strain-r2b-expressing-green-fluorescent-protein
#19
Madhan Mohan Chellappa, Sohini Dey, Satish Gaikwad, Dinesh C Pathak, Vikram N Vakharia
Newcastle disease virus (NDV), strain R2B is a mesogenic vaccine strain used for booster vaccination in chickens against Newcastle disease in India and many south East Asian countries. A full-length cDNA clone of the virus was generated by ligating eight overlapping fragments generated by reverse transcription polymerase chain reaction having unique restriction enzyme sites within them. This full-length cDNA clone was flanked by hammerhead ribozyme and hepatitis delta virus ribozyme sequences. Defined genetic markers were introduced into the NDV genome to differentiate the rescued virus from the parent virus...
February 9, 2017: Virus Genes
https://www.readbyqxmd.com/read/28183763/full-genomic-characterization-of-a-lentogenic-newcastle-disease-virus-isolated-from-farm-reared-ostriches-struthio-camelus-in-northwest-china
#20
Shanhui Ren, Chongyang Wang, Xiaolong Gao, Xue Zhang, Xiangwei Wang, Yanqing Jia, Yanhong Wang, Xinglong Wang, Zengqi Yang
To our knowledge, our study is the first to report the whole-genome sequence of an ostrich-origin Newcastle disease virus (NDV) isolate, abbreviated as Ostrich/SX-01/06. Phylogenetic analysis revealed that this isolate belongs to the subgenotype c in class II. The identification of the complete genome will provide useful information regarding ostrich diseases, especially NDV.
February 9, 2017: Genome Announcements
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