Riddhima Banga, Francesco Andrea Procopio, Erica Lana, Gregory T Gladkov, Isabelle Roseto, Elizabeth M Parsons, Xiaodong Lian, Marie Armani-Tourret, Maxime Bellefroid, Ce Gao, Annamaria Kauzlaric, Mathilde Foglierini, Oscar Alfageme-Abello, Susanna H M Sluka, Olivia Munoz, Andrea Mastrangelo, Craig Fenwick, Yannick Muller, Catherine Gerald Mkindi, Claudia Daubenberger, Matthias Cavassini, Rafael Trunfio, Sébastien Déglise, Jean-Marc Corpataux, Mauro Delorenzi, Mathias Lichterfeld, Giuseppe Pantaleo, Matthieu Perreau
Although gut and lymph node (LN) memory CD4 T cells represent major HIV and simian immunodeficiency virus (SIV) tissue reservoirs, the study of the role of dendritic cells (DCs) in HIV persistence has long been limited to the blood due to difficulties to access lymphoid tissue samples. In this study, we show that LN migratory and resident DC subpopulations harbor distinct phenotypic and transcriptomic profiles. Interestingly, both LN DC subpopulations contain HIV intact provirus and inducible replication-competent HIV despite the expression of the antiviral restriction factor SAMHD1...
September 14, 2023: Cell Host & Microbe