solution atelectasis hypertonic

BACKGROUND: There is insufficient research into the use of mechanical ventilation with increased inspiratory oxygen concentration (FiO2 ) and fluid resuscitation with hypertonic saline solution in patients with septic shock. We tested whether these interventions are associated with reduced mortality. METHODS: This two-by-two factorial, multicentre, randomised, clinical trial (HYPERS2S) recruited patients aged 18 years and older with septic shock who were on mechanical ventilation from 22 centres in France...

BACKGROUND: Despite the lack of randomized trials, nebulized Dornase alpha and hypertonic saline are used empirically to treat atelectasis in mechanically ventilated patients. Our objective was to determine the clinical and radiological efficacy of these medications as an adjunct to standard therapy in critically ill patients. METHODS: Mechanically ventilated patients with new onset (<48 h) lobar or multilobar atelectasis were randomized into three groups: nebulized Dornase alpha, hypertonic (7%) saline or normal saline every 12 h...

BACKGROUND: The purpose of the present study was to compare the cost-effectiveness and efficacy of nebulizer recombinant human DNase (rhDNase) and hypertonic saline (HS) as monotherapy and combined treatment in neonatal atelectasis. METHODS: Eighty-seven newborns with persistent atelectasis who did not respond to traditional treatment were studied retrospectively. Group 1 did not receive nebulizer drugs; Group 2 received 7%HS; Group 3 received rhDNase; and Group 4 received both 7%HS and rhDNase...

OBJECTIVE: The aim of this study was to compare and evaluate the efficacy of nebulized 3% hypertonic saline (HS) and recombinant human DNase (rhDNase) treatment for resolution of persistent atelectasis in newborns. STUDY DESIGN: Forty newborns (38 preterms) who did not respond to conventional treatment were enrolled to receive either nebulized 3% HS solution (n = 20) or rhDNase (n = 20) between September 2007 and March 2008. Clinical parameters, oxygen saturation and radiological response (chest X-ray scoring) were analyzed before and after administration of 3% HS or rhDNase...

BACKGROUND: Bronchial healing remains one of the dominant issues in lung transplantation. Among other factors the quality of airway protection during lung procurement may contribute to improve bronchial healing. METHODS: Thirty-three pigs were divided into four groups: controls (n = 6), those receiving antegrade delivery of Euro-Collins solution with (n = 4) and without prostacyclin (n = 9), and those receiving retrograde delivery of Euro-Collins solution (n = 14)...

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Topical cooling of the lung was compared with cold crystalloid pulmonary artery perfusion with modified Euro-Collins solution in a canine model of unilateral left lung allotransplantation with ligation of the recipient's contralateral pulmonary artery and main bronchus. Lung preservation for 6 hours was achieved by topical cooling and storage at 4 degrees C after absorption atelectasis in five dogs and in a further five dogs by pulmonary arterial perfusion of Euro-Collins solution; 60 ml/kg at 4 degrees C, modified with MgSO4 6 mmol/L followed by storage at 4 degrees C...