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Heather E Wheeler, Keston Aquino-Michaels, Eric R Gamazon, Vassily V Trubetskoy, M Eileen Dolan, R Stephanie Huang, Nancy J Cox, Hae Kyung Im
High-confidence prediction of complex traits such as disease risk or drug response is an ultimate goal of personalized medicine. Although genome-wide association studies have discovered thousands of well-replicated polymorphisms associated with a broad spectrum of complex traits, the combined predictive power of these associations for any given trait is generally too low to be of clinical relevance. We propose a novel systems approach to complex trait prediction, which leverages and integrates similarity in genetic, transcriptomic, or other omics-level data...
July 2014: Genetic Epidemiology
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