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Computational fluid dynamics of coronary flow

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https://www.readbyqxmd.com/read/29693768/simultaneous-kissing-stents-to-treat-unprotected-left-main-stem-coronary-artery-bifurcation-disease-stent-expansion-vessel-injury-hemodynamics-tissue-healing-restenosis-and-repeat-revascularization
#1
Paul D Morris, Javaid Iqbal, Claudio Chiastra, Wei Wu, Francesco Migliavacca, Julian P Gunn
OBJECTIVES: To perform detailed analysis of stent expansion, vessel wall stress, hemodynamics, re-endothelialization, restenosis, and repeat PCI in the simultaneous kissing stents (SKS) technique of bifurcation left main stem (LMS) stenting. BACKGROUND: The SKS technique is useful to treat patients with true bifurcation disease of the LMS but remains controversial. METHODS AND RESULTS: Computational structural analysis of SKS expansion demonstrated undistorted and evenly expanded stents...
April 25, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29660973/computation-of-hemodynamics-in-eccentric-coronary-stenosis-a-morphological-parametric-study
#2
Xinzhou Xie, Yabing Li, Songyun Xie
BACKGROUND: Flow recirculation occurs in eccentric coronary stenosis, which can lead to adverse outcome. The complex local geodesic patterns of eccentric stenosis are critical factors in determining the flow characteristics in post-stenotic flow. OBJECTIVE: The main objective of this study is to relate the relationship between the detailed morphological parameters in eccentric coronary stenosis and the post-stenotic flow characteristics. METHODS: Several idealized eccentric coronary stenosis models with variable morphological parameters are created to conduct a series of computational fluid dynamics analysis...
April 7, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29644234/modelling-coronary-flow-after-the-norwood-operation-influence-of-a-suggested-novel-technique-for-coronary-transfer
#3
Mohammed K Al-Jughiman, Maryam A Al-Omair
Background: The dynamic behavior of the aortic sinuses has an important function in the specific characteristics of coronary blood flow. Several publications have confirmed suboptimal myocardial perfusion after the Norwood procedure. Our study was undertaken to confirm four hypotheses. First, we hypothesized that there is more resistance to coronary flow due to coronary attachments to hypoplastic aortic root and sinuses. Also, as the amalgamation of the ascending aorta with the pulmonary artery occurs above the aortic root, the coronary blood flow is not fully in antegrade pattern...
March 14, 2018: Global Cardiology Science & Practice
https://www.readbyqxmd.com/read/29576586/local-flow-patterns-after-implantation-of-bioresorbable-vascular-scaffold-in-coronary-bifurcations-novel-findings-by-computational-fluid-dynamics
#4
Yingguang Li, Zehang Li, Emil N Holck, Bo Xu, Antonios Karanasos, Zhenyu Fei, Yunxiao Chang, Miao Chu, Jouke Dijkstra, Evald H Christiansen, Johan H C Reiber, Niels R Holm, Shengxian Tu
BACKGROUND: Development of methods for accurate reconstruction of bioresorbable scaffolds (BRS) and assessing local hemodynamics is crucial for investigation of vascular healing after BRS implantation.Methods and Results:Patients with BRS that crossed over in a coronary bifurcation were included for analysis. Reconstructions of the coronary lumen and BRS were performed by fusion of optical coherence tomography and coronary angiography generating a tree model (TM) and a hybrid model with BRS (TM-BRS)...
March 24, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29575961/effect-of-magnetic-field-on-haemodynamic-perturbations-in-atherosclerotic-coronary-arteries
#5
Ashkan Javadzadegan, Abouzar Moshfegh, Masud Behnia
Haemodynamic perturbations including elevated blood viscosity, low and oscillatory shear stress are understood to be important pathogenic mediators in atherosclerosis. These haemodynamic abnormalities are influenced by the presence of a magnetic field. This study conducted computational fluid dynamics (CFD) analysis in 4 coronary artery models, derived from authentic human coronaries, with mild and moderate and severe stenosis severity. The aim was to investigate the effect of a static magnetic field of varying intensities on blood viscosity, areas of low wall shear stress (ALWSS), maximum wall shear stress (MWSS) and length and volume of flow recirculation zones...
March 26, 2018: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/29570758/benchmark-for-numerical-models-of-stented-coronary-bifurcation-flow
#6
Pedro Garcia Carrascal, Javier Garcia, Jose Sierra Pallares, Francisco Castro Ruiz, Fernando Manuel Martín
In-stent restenosis ails many patients who have undergone stenting. When the stented artery is a bifurcation, the intervention is especially critical because of the complex stent geometry involved in these structures. Computational Fluid Dynamics (CFD) has demonstrated to be an effective approach when modelling blood flow behavior and understanding the mechanisms that underlie in-stent restenosis. These CFD models, however, require validation through experimental data in order to be reliable. It is with this purpose in mind that we performed Particle Image Velocimetry (PIV) measurements of velocity fields within flows through a simplified coronary bifurcation...
March 22, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29566702/a-new-cfd-based-non-invasive-method-for-functional-diagnosis-of-coronary-stenosis
#7
Xinzhou Xie, Minwen Zheng, Didi Wen, Yabing Li, Songyun Xie
BACKGROUND: Accurate functional diagnosis of coronary stenosis is vital for decision making in coronary revascularization. With recent advances in computational fluid dynamics (CFD), fractional flow reserve (FFR) can be derived non-invasively from coronary computed tomography angiography images (FFRCT ) for functional measurement of stenosis. However, the accuracy of FFRCT is limited due to the approximate modeling approach of maximal hyperemia conditions. To overcome this problem, a new CFD based non-invasive method is proposed...
March 22, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29550316/identification-of-high-risk-plaques-destined-to-cause-acute-coronary-syndrome-using-coronary-computed-tomographic-angiography-and-computational-fluid-dynamics
#8
Joo Myung Lee, Gilwoo Choi, Bon-Kwon Koo, Doyeon Hwang, Jonghanne Park, Jinlong Zhang, Kyung-Jin Kim, Yaliang Tong, Hyun Jin Kim, Leo Grady, Joon-Hyung Doh, Chang-Wook Nam, Eun-Seok Shin, Young-Seok Cho, Su-Yeon Choi, Eun Ju Chun, Jin-Ho Choi, Bjarne L Nørgaard, Evald H Christiansen, Koen Niemen, Hiromasa Otake, Martin Penicka, Bernard de Bruyne, Takashi Kubo, Takashi Akasaka, Jagat Narula, Pamela S Douglas, Charles A Taylor, Hyo-Soo Kim
OBJECTIVES: We investigated the utility of noninvasive hemodynamic assessment in the identification of high-risk plaques that caused subsequent acute coronary syndrome (ACS). BACKGROUND: ACS is a critical event that impacts the prognosis of patients with coronary artery disease. However, the role of hemodynamic factors in the development of ACS is not well-known. METHODS: Seventy-two patients with clearly documented ACS and available coronary computed tomographic angiography (CTA) acquired between 1 month and 2 years before the development of ACS were included...
March 14, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29550308/virtual-coronary-intervention-a-treatment-planning-tool-based-upon-the-angiogram
#9
Rebecca C Gosling, Paul D Morris, Daniel A Silva Soto, Patricia V Lawford, D Rodney Hose, Julian P Gunn
OBJECTIVES: This study sought to assess the ability of a novel virtual coronary intervention (VCI) tool based on invasive angiography to predict the patient's physiological response to stenting. BACKGROUND: Fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) is associated with improved clinical and economic outcomes compared with angiographic guidance alone. Virtual (v)FFR can be calculated based upon a 3-dimensional (3D) reconstruction of the coronary anatomy from the angiogram, using computational fluid dynamics (CFD) modeling...
March 9, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29530025/carotid-dsa-based-cfd-simulation-in-assessing-the-patient-with-asymptomatic-carotid-stenosis-a-preliminary-study
#10
Dong Zhang, Pengcheng Xu, Hongyu Qiao, Xin Liu, Liangping Luo, Wenhua Huang, Heye Zhang, Changzheng Shi
BACKGROUND: Cerebrovascular events are frequently associated with hemodynamic disturbance caused by internal carotid artery (ICA) stenosis. It is challenging to determine the ischemia-related carotid stenosis during the intervention only using digital subtracted angiography (DSA). Inspired by the performance of well-established FFRct technique in hemodynamic assessment of significant coronary stenosis, we introduced a pressure-based carotid arterial functional assessment (CAFA) index generated from computational fluid dynamic (CFD) simulation in DSA data, and investigated its feasibility in the assessment of hemodynamic disturbance preliminarily using pressure-wired measurement and arterial spin labeling (ASL) MRI as references...
March 12, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/29512059/patient-specific-cardiovascular-computational-modeling-diversity-of-personalization-and-challenges
#11
REVIEW
Richard A Gray, Pras Pathmanathan
Patient-specific computer models have been developed representing a variety of aspects of the cardiovascular system spanning the disciplines of electrophysiology, electromechanics, solid mechanics, and fluid dynamics. These physiological mechanistic models predict macroscopic phenomena such as electrical impulse propagation and contraction throughout the entire heart as well as flow and pressure dynamics occurring in the ventricular chambers, aorta, and coronary arteries during each heartbeat. Such models have been used to study a variety of clinical scenarios including aortic aneurysms, coronary stenosis, cardiac valvular disease, left ventricular assist devices, cardiac resynchronization therapy, ablation therapy, and risk stratification...
April 2018: Journal of Cardiovascular Translational Research
https://www.readbyqxmd.com/read/29501225/quantification-of-disturbed-coronary-flow-by-disturbed-vorticity-index-and-relation-with-fractional-flow-reserve
#12
Miao Chu, Clemens von Birgelen, Yingguang Li, Jelmer Westra, Junqing Yang, Niels R Holm, Johan H C Reiber, William Wijns, Shengxian Tu
BACKGROUND AND AIMS: The relation between FFR and local coronary flow patterns is incompletely understood. We aimed at developing a novel hemodynamic index to quantify disturbed coronary flow, and to investigate its relationship with lesion-associated pressure-drop, and fractional flow reserve (FFR). METHODS: Three-dimensional angiographic reconstruction and computational fluid dynamics were applied to simulate pulsatile coronary flow. Disturbed vorticity index (DVI) was derived to quantify the stenosis-induced flow disturbance...
June 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29500919/simulation-of-personalised-haemodynamics-by-various-mounting-positions-of-a-prosthetic-valve-using-computational-fluid-dynamics
#13
Markus Bongert, Marius Geller, Werner Pennekamp, Volkmar Nicolas
Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients...
March 3, 2018: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/29488883/-less-invasive-fractional-flow-reserve-measurement-from-3-dimensional-quantitative-coronary-angiography-and-classic-fluid-dynamic-equations
#14
Balazs Tar, Csaba Jenei, Csaba Andras Dezsi, Sandor Bakk, Zoltan Beres, Janos Santa, Marianna Svab, Veronika Szentes, Peter Polgar, Csaba Bujaky, Daniel Czuriga, Zsolt Kőszegi
AIMS: To develop a simplified model of FFR calculation (FFRsim) deriving from 3-dimensional (3D) coronary angiographic data and classic fluid dynamic equations without using finite element analysis. METHODS AND RESULTS: Intracoronary pressure measurements were performed by pressure wire sensors. Lumens of the interrogated vessel segments were reconstructed in 3D. The coronary artery volumetric flow was calculated based on the velocity of the contrast material. Pressure gradients were computed by classic fluid dynamic equations...
February 27, 2018: EuroIntervention
https://www.readbyqxmd.com/read/29450473/elevated-blood-viscosity-and-microrecirculation-resulting-from-coronary-stent-malapposition
#15
Eric K W Poon, Vikas Thondapu, Umair Hayat, Peter Barlis, Chooi Yin Yap, Po-Hung Kuo, Qisen Wang, Jiawei Ma, Shuang J Zhu, Stephen Moore, Andrew S H Ooi
One particular complexity of coronary artery is the natural tapering of the vessel with proximal segments having larger caliber and distal tapering as the vessel get smaller. The natural tapering of a coronary artery often leads to proximal incomplete stent apposition (ISA). ISA alters coronary hemodynamics and creates pathological path to develop complications such as in-stent restenosis, and more worryingly, stent thrombosis (ST). By employing state-of-the-art computer-aided design software, generic stent hoops were virtually deployed in an idealized tapered coronary artery with decreasing malapposition distance...
May 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29190348/computational-fluid-dynamics-study-of-the-end-side-and-sequential-coronary-artery-bypass-anastomoses-in-a-native-coronary-occlusion-model
#16
Kaoru Matsuura, Wei Wei Jin, Hao Liu, Goro Matsumiya
OBJECTIVES: The objective of this study was to evaluate the haemodynamic patterns in each anastomosis fashion using a computational fluid dynamic study in a native coronary occlusion model. METHODS: Fluid dynamic computations were carried out with ANSYS CFX (ANSYS Inc., Canonsburg, PA, USA) software. The incision lengths for parallel and diamond anastomoses were fixed at 2 mm. Native vessels were set to be totally occluded. The diameter of both the native and graft vessels was set to be 2 mm...
April 1, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29184766/an-investigation-of-correlation-between-left-coronary-bifurcation-angle-and-hemodynamic-changes-in-coronary-stenosis-by-coronary-computed-tomography-angiography-derived-computational-fluid-dynamics
#17
Zhonghua Sun, Thanapong Chaichana
Background: To investigate the correlation between left coronary bifurcation angle and coronary stenosis as assessed by coronary computed tomography angiography (CCTA)-generated computational fluid dynamics (CFD) analysis when compared to the CCTA analysis of coronary lumen stenosis and plaque lesion length with invasive coronary angiography (ICA) as the reference method. Methods: Thirty patients (22 males, mean age: 59±6.9 years) with calcified plaques at the left coronary artery were included in the study with all patients undergoing CCTA and ICA examinations...
October 2017: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29124548/development-of-an-experimental-and-digital-cardiovascular-arterial-model-for-transient-hemodynamic-and-postural-change-studies-a-preliminary-framework-analysis
#18
Rodward L Hewlin, John P Kizito
The ultimate goal of the present work is to aid in the development of tools to assist in the treatment of cardiovascular disease. Gaining an understanding of hemodynamic parameters for medical implants allow clinicians to have some patient-specific proposals for intervention planning. In the present work an experimental and digital computational fluid dynamics (CFD) arterial model consisting of a number of major arteries (aorta, carotid bifurcation, cranial, femoral, jejunal, and subclavian arteries) were fabricated to study: (1) the effects of local hemodynamics (flow parameters) on global hemodynamics (2) the effects of transition from bedrest to upright position (postural change) on hemodynamics, and (3) diffusion of dye (medical drug diffusion simulation) in the arterial system via experimental and numerical techniques...
March 2018: Cardiovascular Engineering and Technology
https://www.readbyqxmd.com/read/29050684/comparison-of-accuracy-of-one-use-methods-for-calculating-fractional-flow-reserve-by-intravascular-optical-coherence-tomography-to-that-determined-by-the-pressure-wire-method
#19
COMPARATIVE STUDY
Sun-Joo Jang, Jung-Min Ahn, Boyoung Kim, Ji-Min Gu, Hyung Jin Sung, Seung-Jung Park, Wang-Yuhl Oh
Although the identification of the hemodynamic significance of coronary lesions becomes important for revascularization strategy, the potential role of 3-dimensional high-resolution intracoronary optical coherence tomography (OCT) for predicting functional significance of coronary lesions remains unclear. We assessed the diagnostic performance of 2 computational approaches for deriving fractional flow reserve (FFR) from intravascular OCT images. We developed 2 methods to derive FFR-OCT by AFD (FFR-OCTAFD ) and FFR-OCT by CFD (FFR-OCTCFD )...
December 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29032800/haemodynamic-effects-of-incomplete-stent-apposition-in-curved-coronary-arteries
#20
Winson X Chen, Eric K W Poon, Vikas Thondapu, Nicholas Hutchins, Peter Barlis, Andrew Ooi
Incomplete stent apposition (ISA, also known as malapposition) is a complication that affects day-to-day coronary stenting procedures. ISA is more prominent in complex arterial geometries, such as curvature, asa result of the limited conformability of coronary stents. These malapposed struts disturb the otherwise near-wall laminar blood flow and form a micro-recirculation environment. The micro-recirculation environment is often associated with low wall shear stress (WSS) and upsets the delicate balance of vascular biology, providing possible nidus for thrombosis and restenosis...
October 3, 2017: Journal of Biomechanics
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